Opener A “Smart Drug”

Figure 17.1 One Gene, One Enzyme (Part 1)

Figure 17.1 One Gene, One Enzyme (Part 2)

Figure 17.2 Hemoglobin Polymorphism

Figure 17.3 Genetic Diseases of Membrane Proteins (Part 1)

Figure 17.3 Genetic Diseases of Membrane Proteins (Part 2)

Figure 17.3 Genetic Diseases of Membrane Proteins (Part 3)

Figure 17.3 Genetic Diseases of Membrane Proteins (Part 4)

Figure 17.4 Prion Proteins

Figure 17.5 A Fragile-X Chromosome at Metaphase

Figure 17.6 Strategies for Isolating Human Genes

Figure 17.7 RFLP Mapping (Part 1)

Figure 17.7 RFLP Mapping (Part 2)

Figure 17.8 5-Methylcytosine in DNA Is a “Hot Spot” for Mutagenesis (Part 1)

Figure 17.8 5-Methylcytosine in DNA Is a “Hot Spot” for Mutagenesis (Part 2)

Figure 17.9 The CGG Repeat in the Fragile-X Gene Expands with Each Generation

Figure 17.10 Genetic Screening of Newborns for Phenylketonuria (Part 1)

Figure 17.10 Genetic Screening of Newborns for Phenylketonuria (Part 2)

Figure 17.11 DNA Testing by Allele-Specific Cleavage

Figure 17.12 DNA Testing by Allele-Specific Oligonucleotide Hybridization (Part 1)

Figure 17.12 DNA Testing by Allele-Specific Oligonucleotide Hybridization (Part 2)

Figure 17.13 A Cancer Cell with Its Normal Neighbors

Figure 17.14 Dividing Cells Are Especially Susceptible to Genetic Damage

Figure 17.15 Oncogene Products Stimulate Cell Division

Figure 17.16 The “Two-Hit” Hypothesis for Cancer

Figure 17.17 Tumor Suppressor Gene Products Inhibit Cell Division and Cancer

Figure 17.18 Multiple Mutations Transform a Normal Colon Epithelial Cell into a Cancer Cell (1)

Figure 17.18 Multiple Mutations Transform a Normal Colon Epithelial Cell into a Cancer Cell (2)

Figure 17.18 Multiple Mutations Transform a Normal Colon Epithelial Cell into a Cancer Cell (3)

Figure 17.19 Strategies for Killing Cancer Cells

Figure 17.20 Gene Therapy: The Ex Vivo Approach (Part 1)

Figure 17.20 Gene Therapy: The Ex Vivo Approach (Part 2)

Figure 17.21 Two Approaches to Sequencing DNA

Figure 17.22 The Human Genome

Figure 17.23 Is This the Future of Medicine?

Figure 17.24 Proteomics (Part 1)

Figure 17.24 Proteomics (Part 2)

Table 17.1 Human Cancers Known To Be Caused by Viruses