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8/8/2019 OPC3 Main Presentation National Convention 2009
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Discovered the involvement ofvitamin C in scurvy
Found that citrus fruits bear othermaterial stabilizing blood vessels
Introduced the term vitamin Pfor flavonoids
Dr. Szent Gyrgi
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Protection from oxidative environment
Protection from microbial decay Protection from insects
The highest amounts are found in a plant's surface:the peel, the bark
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OH
OH
OH
Resveratrol is atri-hydroxy-stilbene
Resveratrol is suggested to have potent anti-aging activity
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O+
OH
OH
R2
OH
OH
R1
Bilberry has been shown to support night-time vision
Effective for strengthening retinal capillaries
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O
OH
OH
OHOH
OH
OHOH
O
OH
OH
OH
O
OH
OH
OHOH
OH
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The maritime pine tree growsfor 30-50 years in anunspoiled environment:
no pesticides no fertilizers no pollution
Ideal botanical source:
mono-culture no seasonal influence
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8/8/2019 OPC3 Main Presentation National Convention 2009
15/4430 years ago
tomorrow
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UV exposure leads to free radical production and inflammationin the skin producing serious damage to skin cells
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0%
20%
40%
60%
80%
100%
Lipidssavedfrom
oxidation
vit C lipoicacid
vit E grapeseed
Pycnogenol
Chida et al., Ophthal Res 31: 407-415, 1999
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Clinical study with
healthy volunteers.
More UV radiation is
required to cause a
sunburn when taking
Pycnogenol.
While not a sunblock,
Pycnogenol does help
protect the skin from
sunburn by its
antioxidant and anti-inflammatory actions.
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Kyriazi et al., Cancer Letters 2005 237: 234-241, 2006
weeks
0 5 10 15 20 25M
icebearin
gpapillom
a
0%
20%
40%
60%
80%
100%nude albino mice nude pigmented mice
pigmented mice
with Pycnogenol
albino mice
+Pycnogenol
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Mean pigmented area size: - 37.7 %Mean intensity index: - 22.4 %
Ni et al., Phytother Res 16: 567-571, 2002
Hyper-pigmentationAreasize[mm2 ]
0
10
20
30
40
50
60
70
Beforetreatment
Aftertreatment
30 women with hyperpigmentation:
25 mg Pycnogenol 3x daily for 30 days
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mitochondria
DNA
Enzymes
cell wall
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mitochondria
DNA
Enzymes
cell wall
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Wei et al., Redox Report 3: 219-224, 1997
SOD Glutathione Catalase
Presence of anti-oxidant enzymes in endothelial cellsafter 8 hour exposure to Pycnogenol
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Devaraj et al., Lipids 37: 931-934, 2002
1
2
3
4
baseline 3 and 6 weeks
Pycnogenol4 weeks
wash-out
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Ryan et al., J Psychopharmacol, in print 2008
101 elderly participants(aged 60-85 years)
Presenting with impairedcognitive function
Memory improvementshown after 3 months
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Cardiovascular disease : disorders of the heart and blood vessels
Coronary heart disease (heart attacks)Cerebrovascular disease (stroke)Cholesterol abnormalitiesRaised blood pressure (hypertension)Peripheral vascular disease (clotting, edema)Heart Failure
Major causes: tobacco use, physical inactivity, and an unhealthy diet
Facts: #1 cause of death globally17.5 million people died from cardiovascular disease in 200530 % of all global deaths7.6 million heart attacks5.7 million strokes
http://www.who.int/topics/cardiovascular_diseases/en/
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arginine
+ O2
blood platelets blood stream
NO NO
NO
NO
NO
NO
endothelial cells of blood vessel wall
Fitzpatrick et al., J Cardiovasc Pharm 32: 509-515, 1998
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Kohama, Progress in Medicine 24: 1503-1510, 2004
22% Mild
Improvement
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Hosseini et al., Nutrition Res 21: 1251-1260, 2001
p
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3 weeks
200 mg a day
3 weeks
100 mg a day
3 weeks
50 mg a day
Liu et al., Diabetes Care 27: 839, 2004
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Increase ofantioxidantimpact rate
units/ minute
10min
20min
30min
40min
50min
60min
70min
80min
90min
2h
2h
3h
3h
4h
0
1
2
3
Cesarone et al., Phytother Res, in print 2008
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Cesarone et al., Angiology 2008
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Cesarone et al., Angiology 2008
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Cesarone et al., Angiology 2008
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Cesarone et al., Angiology 2008
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Cesarone et al., Angiology 2008
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