「脳の発達とストレス」グループ著者名論文標題雑誌名査 …Sustained-release progesterone vaginal suppositories 1―Development of sustained-release granule―

「脳の発達とストレス」グループ著者名論文標題雑誌名査読巻ページ発行年

Keiichi Uchiya, Asami Sugita, and Toshiaki Nikai

Involvement of SPI-2-encoded SpiC in flagellum synthesis in Salmonella enterica serovar Typhimurium

BMC Microbiol.

有 In press

Eun-Joo Shin ,Guoying Bing, Jong Seok Chae, Tae Woo Kim, Jae-Hyung Bach, Dae Hun Park, Kiyofumi Yamada, Toshitaka Nabeshima, Hyoung-Chun Kim.

Role of microsomal epoxide hydrolase in the methamphetamine-induced drug dependence in mice.

J. Neurosci. Res.

有 In press

Chun-Hui Jin, Eun-Joo Shin, Jae-Bong Park, Choon-Gon Jang, Zhengyi Li, Min Soo Kim, Kyo Hwan Koo, Hyoung-Jong Yoon, Sang-Jae Park, Won-Cheol Choi, Kiyofumi Yamada, Toshitaka Nabeshima, Hyoung-Chun Kim.

Fustin flavonoid attenuates β-amyloid (1-42)-induced learning impairment.

J. Neurosci. Res.

有 In press

Hiroyuki Mizoguchi, Kazuhiro Takuma, Emiko Fukuzaki, Daisuke Ibi, Eiichi Someya, Ko-hei Akazawa, Tursun Alkam, Hiroko Tsunekawa, Akihiro Mouri, Yukihiro Noda, Toshitaka Nabeshima and Kiyofumi Yamada.

Matrix metalloprotease-9 inhibition improves amyloid b-mediated cognitive impairment and neurotoxicity in mice.

J. Pharmacol. Exp. Ther.

有 In press

Ping Lu, Takayoshi Mamiya, Lingling, Akihiro Mouri, Minae Niwa, M. Hiramatsu, Li-Bo Zou, Takahshi Ikejima, Taku Nagai and Toshitaka Nabeshima

Silibinin attenuates amyloid25-35 peptide-induced memory impairments: Implication of inducible nitric oxide synthase (iNOS) and tumor necrosis factor-alpha (TNF-a) in mice


有 In press

Hiroyuki Mizoguchi, Sawako Arai, Hiroyuki Koike , Daisuke Ibi, Hiroyuki Kamei , Toshitaka Nabeshima , Hyoung-Chun Kim , Kazuhiro Takuma, Kiyofumi Yamada

Therapeutic potential of nicotine for methamphetamine-induced impairment of sensorimotor gating: involvementof pallidotegmental neurons

Psychopharmacology

In press

Yukari Matsui, Y. Hirabayashi, Y. Kawasaki, T. Toyoshi, K. Kyuki, Mikio. Ito

Strain differences in high fat diet-induced obesity and glucose intolerance in mice (in press).

OyoYakuri/Pharmocometrics

有 In press

Koji Ueda Effect of environmental chemicals on genes and the expression

Yakugaku Zasshi

有 In press

Hiroyuki Koike, Daisuke Ibi, Hiroyuki Mizoguchi, Taku Nagai, Atsumi Nitta, Kazuhiro Takuma, Toshitaka Nabeshima, Yukio Yoneda and Kiyofumi Yamada.

Behavioral abnormality and pharmacologic response in social isolation-reared mice.

Behav. Brain Res.

有 202 114-121 平成21年

A. Nakayama, H. Sunada, H. Okamoto, K. Huruhashi, Y. Ohno, and Mikio. Ito

Sustained-release progesterone vaginal suppositories 1―Development of sustained-release granule―.

Biol. Pharm. Bull.

有 32 276-282 平成21年

Takafumi Kuzawa, Takaaki Kobayashi,Akio Katayama, Takaharu Nagase, Yuko Miwa, Kazuharu Uchida, Akimasa Nakao, and Kiyofumi Yamada.

Evaluation of interleukin-2 mRNA in whole blood as a parameter for monitoring cyclosporine pharmacodynamics.

Biol. Pharm. Bull.

有 32 604-608 平成21年

Noboru Otsuka, Katsuki Tsuritani, Takanobu Sakurai, Kikuya Kato, Ryo Matoba, Jiro Itoh, Shigeru Okuyama, Kiyofumi Yamada, Yukio Yoneda.

Transcriptional induction and translational inhibition of Arc and Cugbp2 in mice hippocampus after transient global ischemia under

Brain Res. 有 1287 136-145 平成21年


normothermic condition.

Koji Ueda Effect of RNA damage on gene expression: Development of the assay system

Bull. Res. Inst. Meijo Univ.

無 14 83-85 平成21年

Nakao Kojima, Koji Ueda, Chitose Toda, Kiyomatsu Hashizume

Estrogenic activities of phytobenzophenones


無 14 103-105 平成21年

Eun Joo Shin, Choon-Gon Jang , Guoying Bing, Dae Hun Park, Chang-Hyun Oh, Kyo Hwan Koo, Ki Wan Oh Kiyofumi Yamada,Toshitaka Nabeshima and Hyoung-Chun Kim.

Prodynorphin gene deficiency potentiates nalbuphine-induced behavioral sensitization and withdrawal syndrome in mice.

Drug Alcohol Dependence.

有 104 175-184 平成21年

Sawako Arai, Kazuhiro Takuma, Hiroyuki Mizoguchi , Daisuke Ibi, Taku Nagai, Hiroyuki Kamei, Hyoung-Chun Kim, Kiyofumi Yamada

GABAB receptor agonist baclofen improve methamphetamine-induced cognitive deficit in mice.

Eur. J. Pharmacol.

有 602 101-104 平成21年

Takayuki Inagaki, Kei Nishimori, Tetsuya Yagi, Kazuya Ichikawa, Makoto Moriyama, Taku Nakawawa, Takami Shibayama, Keiichi Uchiya, Toshiaki Nikai, and Kenji Ogawa

Comparison of a Variable-Number Tandem-Repeat (VNTR) method for typing Mycobacterium avium with Mycobacterial Interspersed Repetitive-Unit-VNTR and IS1245 restriction fragment length polymorphism typing.

J. Clin. Microbiol.

有 47 2156-2164 平成21年

Masayuki Yamamoto, Takafumi Kuzuya, Kiyofumi Yamada and Toshitaka Nabeshima.

Population pharmacokinetic analysis of vancomycin in patients with gram-positive infections and the influence of infectious disease type.

J. Clin. Pharm. Ther.

有 34 473-483 平成21年

Motozumi Ando, Koji Ueda, Rena Makino, Yoshihiko Nishino, Hiroyuki Nishida, Chitose Toda, Yoshinori Okamoto, Nakao Kojima

Involvement of DNA conformational change induced by rearrangement of copper-coordination geometry in oxidative DNA damages caused by copper and dopamine

J. Health Sci. 有 55 319-323 平成21年

Kazuya Ichikawa, Tetsuya Yagi, Makoto Moriyama, Takayuki Inagaki, Taku Nakagawa, Keiichi Uchiya, Toshiaki Nikai, and Kenji Ogawa

Characterization of Mycobacterium avium with clinical isolates in Japan using subspecies-specific insertion sequences, and identification of a new insertion sequence, ISMav6.

J. Med. Microbiol.

有 58 945-950 平成21年

Bin Gu, Noritaka Nakamichi, Wen-Sheng Zhang, Yukary

Nakamura, Yuki Kambe, Ryo Fukumori, Kazuhiro Takuma, Kiyofumi Yamada, Takishu Takarada, Hideo Taniura, Yukio Yoneda.

Possible protection by notoginsenoside R1 against glutamate neurotoxicity mediated by N-methyl-D-aspartate receptors composed of an NR1/NR2B subunit assembly.

J. Neurosci. Res.

有 87 2145-2156 平成21年

Eun-Joo Shin, Jong Seok Chae, Seok Joo Park, Sun Cheol Kim, Kyo Hwan Koo, Kiyofumi Yamada, Toshitaka Nabeshima, and Hyoung-Chun Kim.

Growth hormone-releaser attenuates �-amyloid (1-42)-induced cognitive impairment via stimulation of the insulin-like growth factor (IGF) -1 receptor in mice.

J. Pharmacol. Sci.

有 109 139-143 平成21年

Haruhide Kimura, Hiroshi Yukitake, Hirobumi Suzuki, Yasukazu Tajima, Koyo Gomaibashi, Shinji Morimoto, Yasunori Funabashi1, Kiyofumi Yamada, and Masayuki Takizawa.

The Chondroprotective Agent ITZ-1 Inhibits IL-1β-Induced MMP-13 Production and Suppresses NO-Induced Chondrocyte Death

J. Pharmacol. Sci.

有 110 201-211 平成21年


Chitose Toda, Motozumi Ando, Koji Ueda, Kiyomatsu Hashizume, Nakao Kojima

Oxidative DNA damage induced by main stream smoke and side stream smoke of cigarette

J. Res. Inst. Meijo Univ.

有 8 47-52 平成21年

Motozumi Ando, Rena Makino, Tsuyoshi Nakai, Yoshihiko Nishino, Koji Ueda, Chitose Toda, Yoshinori Okamoto, Hiroyuki Nishida, Nakao Kojima

Regulation of metal/chemical-mediated DNA/RNA damage disrupting gene expression

J. Toxicol. Sci.

無 34S S86 平成21年

Vanessa Villard, Julie Espallergues, Emeline Keller, Tursun Alkam, Atsumi Nitta, Kiyofumi Yamada, Toshitaka Nabeshima, Alexandre Vamvakides and Tangui Maurice

Anti-amnesic and neuroprotective effects of the aminotetrahydrofuran derivative ANAVEX1-41 against amyloid β25-35 -induced toxicity in mice.

Neuropsychopharmacology.

有 34 1552-1566 平成21年

Daisuke Ibi, Taku Nagai, Yuko Kitahara, Hiroyuki Mizoguchi, Hiroyuki Koike, Anna Shiraki, Kazuhiro Takuma, Hiroyuki Kamei, Yukihiro Noda, Atumi Nitta, Toshitaka Nabeshima, Yukio Yoneda and Kiyofumi Yamada.

Neonatal polyI:C treatment in mice results in schizophrenia-like behavioral and neurochemical abnormalities in adulthood

Neurosci. Res. 有 64 297-305 平成21年

中山綾子、砂田久一、岡本浩一、近

藤東臣、大野佑希子、伊藤幹雄除放性プロゲステロン膣座剤—第

２報：開発と評価— 医療薬学有 35 343-350 平成21年

伊藤幹雄＜特集＞広がりつつあるサプリメ

ントを理解するー腎不全患者に活

用するために〔各論〕9. キチン/キトサン

臨床透析無 24 1764-1766 平成21年

Tursun Alkam, Atsumi Nitta, Hiroyuki Mizoguchi, Kuniaki Saito, Mitsuru Seshima, Akio Itoh, Kiyofumi Yamadaa, Toshitaka Nabeshima

Restraining tumor necrosis factor-alpha by thalidomide prevents the Abeta-induced impairment of recognition memory in mice

Behav. Brain Res.

有 189 100-106 平成 20 年

Yoshinori Okamoto, Tomohiro Hayashi, Shinpei Matsunami, Koji Ueda, Nakao Kojima

Combined activation of methyl paraben by light irradiation and esterase metabolism toward oxidative DNA damage

Chem. Res. Toxicol.

有 21 1594-1599 平成 20 年

Masashi Ishihara, Ryoji Kojima, Mikio Ito

Influence of aging on gastric ulcer healing activities of α-tocopherol and probucol, antioxidants.

Eur. J. Pharmacol.

有 601 143-147 平成 20 年

Kohji Yano, Keiko Yamamura, Takashi Osada, Fumiaki Fukase, Noriko Kiriyama, Mayumi Torimoto, Kiyofumi Yamada, Donald T Kishi and Toshitaka Nabeshima

Documenting the value of a pharmacist-managed anticoagulation classroom.

J. Appl. Ther. Res

有 6 41-48 平成 20 年

Motozumi Ando, Hiroyuki Nishida, Kazuo Ito, Yujiro Nishida, Koji Ueda, Chitose Toda, Nakao Kojima

Synthesis of unique compounds for development of useful activities of selenium

J. Health Sci. 無 54S 184 平成 20 年

Chitose Toda, Ai Ito, Motozumi Ando, Koji Ueda, Nakao Kojima

Oxidative DNA damage induced by main stream smoke and side stream smoke of cigarette


Rena Makino, Motozumi Ando, Tsuyoshi Nakai, Yoshihiko Nishino, Koji Ueda, Chitose Toda, Nakao Kojima

Catechols with carbonyl side-chain suppress the oxidative DNA damage through redox complex formation with copper.


Yoshihiko Nishino, Motozumi Ando, Rena Makino, Tsuyoshi Nakai, Koji

Effects of RNA damage caused by metals and neurotransmitters on



Ueda, Chitose Toda, Nakao Kojima

gene expression

Yoshiyuki Okumura, Takeshi Matsui, Kenji Ogawa, Keiichi Uchiya, and Toshiaki Nikai

Biological properties and primary structure of elastase inhibitor AFUEI from Aspergillus fumigatus

J. Med. Microbiol.

有 57 803-808 平成 20 年

Daisuke Ibi, Kazuhiro Takuma, Hiroyuki Koike, Hiroyuki Mizoguchi,Katumi Tsuritani, Yusuke Kuwahara, Hiroyuki Kamei, Taku Nagai, Yukio Yoneda, Toshitaka Nabeshima and Kiyofumi Yamada

Social isolation rearing-induced impairment of the hippocampal neurogenesis is associated with deficits in spatial memory and emotion-related behaviors in juvenile mice.

J. Neurochem 有 105 921-932 平成 20 年

Keisuke Tamaki, Kiyofumi Yamada, Noritake Nakamichi, Hideo Taniura and Yukio Yoneda

Transient suppression of progenitor cell proliferation through NMDA receptors in hippocampal dentate gyrus of mice with traumatic stress experience.

J. Neurochem. 有 105 1642- 1655

平成 20 年

Ayumi Fukakusa, Taku Nagai, Hiroyuki Mizoguchi, Noboru Otsuka, Haruhide Kimura, Hiroyuki Kamei, Hyoung-Chun Kim, Toshitaka Nabeshima, kazuhiro Takuma and Kiyofumi Yamada

Role of tissue plasminogen activator in the sensitization of methamphetamine-induced dopamine release in the nucleus accumbens.

J. Neurochem. 有 105 436-444 平成 20 年

Minae Niwa, Atumi Nitta, Xiaobo Cen, Kiyoyuki Kitaichi, Noriko Ozaki, Kiyofumi Yamada and Toshitaka Nabeshima

A novel molecule ‘shati’ increases dopamine uptake via the induction of tumor necrosis factor-α| in pheochromocytoma-12 cells

J. Neurochem. 有 107 1697- 1708

平成 20 年

Jun Kawanokuchi, Kouki Shimizu, Atsumi Nitta, Kiyofumi Yamada, Tetsuya Mizuno,Hideyuki Takeuchi, Akio Suzumura

Production and functions of IL-17 in microglia.

J. Neuroimmunol.

有 194 54-61, 平成 20 年

Tursun Alkam, Atsumi Nitta, Hiroyuki Mizoguchi, Akio Itoh, Rina Murai, Taku Nagai, Kiyofumi Yamada, and Toshitaka Nabeshima

The extensive nitration of neurofilament light chain in the hippocampus is associated with the cognitive impairment induced by amyloid b in mice.


有 327 137-147 平成 20 年

Ayumi Fukakusa1, Hiroyuki Mizoguchi, Hiroyuki Koike, Toshitaka Nabeshima, Kazuhiro Takuma, and Kiyofumi Yamada

Tissue plasminogen activator is not involved in methamphetamine-induced neurotoxicity.

J. Pharmacol. Sci.

有 104 321-324 平成 20 年

Motozumi Ando, Koji Ueda, Rena Makino, Yuta Komatsu, Tsuyoshi Nakai, Yoshihiko Nishino, Hiroki Mizuno, Manabu Ohbayashi, Nakao Kojima

Conformation change and oxidative damage of DNA induced by copper-catechol redox system

J. Res. Inst. Meijo Univ.

有 7 81-88 平成 20 年

Koji Ueda, Motozumi Ando, Rena Makino, Tsuyoshi Nakai, Yoshihiko Nishino, Chitose Toda, Nakao Kojima

Effects of metal binding to DNA on the conformation and genetic information

J. Toxicol. Sci.

無 33S S128 平成 20 年

Keiichi Uchiya and Toshiaki Nikai Salmonella virulence factor SpiC is involved in expression of flagellin protein and mediates activation of the signal transduction pathways in macrophages

Microbiology 有 154 3491-3502 平成 20 年

Emiko Fukuzaki, Kazuhiro Takuma, Yoko Funatsu, Yukiko Himeno, Yuko Kitahara, Bin Gu, Hiroyuki Mizoguchi, Daisuke Ibi, Koji Koike, Masaki Inoue, Shi Du Yan and

Ovariectomy increases neuronal amyloid b binding alchohol dehydrogenease level in the mouse hippocampus.

Neurochem. Int.

有 52 1358-1364 平成 20 年


Kiyofumi Yamada Sawako Arai, Kazuhiro Takuma, Hiroyuki Mizoguchi, Daisuke Ibi, Taku Nagai, Kenji Takahashi, Hiroyuki Kamei, Toshitaka Nabeshima and Kiyofumi Yamada

Involvement of pallidotegmental neurons in methamphetamine- and MK-801-induced impairment of prepulse inhibition of the acoustic startle reflex in mice: reversal by GABAB receptor agonist baclofen.

Neuropsychopharmacology

有 33 3164-3175 平成 20 年

Emiko Fukuzaki , Kazuhiro Takuma, Yukiko Himeno, Shigeru Yoshida, Yoko Funatsu, Yuko Kitahara, Hiroyuki Mizoguchi, Daisuke Ibi, Koji Koike, Masaki Inoue, Kiyofumi Yamada

Enhanced activity of hippocampal BACE1 in a mouse model of postmenopausal memory deficits

Neurosci. Lett.

有 433 141-145 平成 20 年

Yoshito Kanazawa, Masato Makino, Yasuo Morishima, Kiyofumi Yamada, Toshitaka Nabeshima, Shirasaki Y

Degradation of PEP-19, a calmodulin-binding protein, by calpain is implicated in neuronal cell death induced by intracellular Ca2+ overload

Neuroscience 有 154 473-81 平成 20 年

Masashi Ishihara, Saori Yasuda, Ryoji Kojima, Mikio Ito

Anti-ulcer effects of Ag・Zn-Zeolite in rats.


有 72 73-79 平成 20 年

Hiroyuki Mizoguchi, Kazuhiro Takuma, Ayumi Fukakusa, Yukio Ito, Akiko Nakatani, Daisuke Ibi, Hyoung-Chun Kim Kiyofumi Yamada

Improvement by minocycline of methamphetamine-induced impairment of recognition memory in mice.

Psychopharmacology (Berl)

有 196 233-241 平成 20 年

Rena Kusu, Ami Oishi, Kimi Kakizawa, Tomomi Kimura, Chitose Toda, Kiyomatsu Hashizume, Koji Ueda, Nakao Kojima

Effects of phthalate ester derivatives including oxidized metabolites on coactivator recruiting by PPARα and PPARγ

Toxicol. in Vitro

有 22 1534-1538 平成 20 年

Motozumi Ando, Rena Makino, Tsuyoshi Nakai, Yoshihiko Nishino, Yuta Komatsu, Hiroki Mizuno, Koji Ueda, Nakao Kojima

Oxidative damage and conformation change of DNA controlled by interaction between several metals and redox compounds

Yakugaku Zasshi

無 128S1 65 平成 20 年

奥山治美、橋本道男、伊藤幹雄、徳

留信寛、島野仁、板倉弘重各種脂肪酸の生理・薬理機能の多

様性

日薬理誌有 131 259-267 平成 20 年

Katura Takano, Yasuko Kitao, Yoshiyuki Tabata, Hikari Miura, Kosuke Sato, Kazuhiro Takuma, Kiyofumi Yamada, Satoshi Hibino, Tominari Choshi, Munekazu Iinuma, Hiroto Suzuki, Rika Murakami, Masashi Yamada, Satoshi Ogawa, and Osamu Hori.

A dibenzoylmethane (DBM) derivative protects dopaminergic neurons against both oxidative stress and endoplasmic reticulum (ER) stress

Am. J. Physiol. Cell Physiol.

有 293 1884-1894 平成 19 年

Kenji Takahashi, Taku Nagai, Hiroyuki Kamei, Kenji Maeda, Takahiro Matsuya, Sawako Arai, Hiroyuki Mizoguchi, Yukio Yoneda, Toshitaka Nabeshima, Kazuhiro Takuma, Kiyofumi Yamada

Neural circuits containing pallidotegmental GABAergic neurons are involved in the prepulse inhibition of tehe star reflex in mice.

Biol. Psychiatry

有 62 148-157 平成 19 年

Koji Ueda Role of androgen receptor in testicular toxicity of phthalate esters―Mechanisms of toxicity enhancement under hepatic dysfunction―


無 12 67-70 平成 19 年

Kiyomatsu Hashizume, Koji Ueda, Responsible factors for enhanced Bull. Res. 無 12 103-108 平成 19 年


Chitose Toda, Nakao Kojima testicular toxicity of DEHP under kidney damage

Inst. Meijo Univ.

Chitose Toda, Koji Ueda, Kiyomatsu Hashizume, Nakao Kojima

Use of bacteria for environmental cleanup―Phthalate esters-degrading enzymes of dimethyl phthalate-acclimated river bacteria―


無 12 109-114 平成 19 年

Rena Kusu, Chitose Toda, Yoshinori Okamoto, Yuko Tozuka, Koji Ueda, Nakao Kojima

Structural properties of estrogen receptor ligand obtained by study of hydroxylated phthalate ester derivatives

Environ. Toxicol. Pharmacol.

有 24 311-315 平成 19 年

Yujin Yan, Kiyofumi Yamada, Minae Niwa, Taku Nagai, Atumi Nitta and Toshitaka Nabeshima

Enduring vulnerability to reinstatement of methamphetamine-seeking behavior in glial cell line-derived neurotrophic factor mutant mice.

FASEB J. 有 21 1994-2004 平成 19 年

Hazimem Taniguchi, Ryoji Kojima, Hiroko Sade, Mayumi Furuya, Norio Inomata, Mikio Ito

Involvement of MPC-0 in tubulointestinal fibrosis through massive proteinuria in anti-GBM nephritis induced by WKY rats.

J. Clin. Immunol.

有 27 409-429 平成 19 年

Motozumi Ando, Rena Makino, Yuta Komatsu, Tsuyoshi Nakai, Hiroki Mizuno, Yoshihiko Nishino, Manabu Obayashi, Koji Ueda, Nakao Kojima

Roles of various metals in oxidative DNA damage involving catechols


Chitose Toda, Miku Kouzuma, Koji Ueda, Kiyomatsu Hashizume, Nakao Kojima

Phthalate derivatives-degrading enzymes of bacteria acclimated by phthalate derivatives


Koji Ueda, Yoko Tawada, Tomomi Kimura, Ayano Tamakoshi, Kimi Kakizawa, Chitose Toda, Nakao Kojima

PPAR-independent toxicological action of phthalate esters


Miwa Ito, Taku Nagi, Hiroyuki Mizoguchi, Ayumi Fukakusa, Yutaka Nakanishi,Hiroyuki Kamei, Toshitaka Nabeshima, Kazuhiro Takuma and Kiyofumi Yamada

Possible involvement of protease-activated receptor-1 in the regulation of morphine-induced dopamine release and hyperlocomotion by the tissue plasminogen activator-plasmin system.

J. Neurochem 有 101 1392-1399 平成 19 年

Hiroyuki Mizoguchi, Kiyofumi Yamada, Akihiro Mouri, MInae Niwa, Tomoko Mizuno, Yukihiro Noda, Atumi Nitta, Shigeyoshi Itohara, Yoshihiro Banno and Toshitaka Nabeshima

Role of matrix metalloproteinase and tissue inhibitor of MMP in methamphetamine-induced behavioral sensitization and reward: implication for dopamine receptor down-regulation and dopamine release.

J. Neurochem. 有 102 1548-1560 平成 19 年

Mina Ito, Taku Nagai, Hiroyuki Mizoguchi, Kosuke Sato, Minoru Hayase, Noboru Otsuka, Ayumi Fukakusa,Nozomi Kumagai,Hyoung-chum Kim, Toshitaka Nabeshima, kazuhiro Takuma and Kiyofumi Yamada

Activation of post-synaptic dopamine D1 receptors promotes the release of tissue plasminogen activator in the nucleus accumbens via PKA signaling.

J. Neurochem. 有 103 2589-2596 平成 19 年

Takahiro Matsuya, Kazuhiro Takuma, Kosuke Sato, Makoto Asai, Yoshihiro Murakami, Sosuke Miyoshi, Akihiro Noda, Taku Nagai, Hiroyuki Mizoguchi1, Shintaro Nishimura, Kiyofumi Yamada

Synergistic effects of adenosine A2A antagonist and L-DOPA on rotational behaviors in 6-Hydroxydopamine-induced hemi-Parkinsonian mouse model.

J. Pharmacol. Sci.

有 103 329-332 平成 19 年


Eun-Joo Shin, Ji Hoon Jeong, Hyoung-Chunc Kim, Choon Gon Jang, Kiyofumi Yamada, Toshitaka Nabeshima and Hyoung-Chun Kim

Exposure to extremely low frequency magnetic fields enhances locomotor activity via activation of dopamine D1-like receptors in mice.

J. Pharmacol. Sci.

有 105 367-371 平成 19 年

Taku Nagai, Toshitaka Nabeshima and Kiyofumi Yamada

Basic and translational research on proteinase-activated receptors: regulation of nicotine reward by the tissue plasminogen activator (tPA) - plasmin system via proteinase -activated receptor 1.

J. Pharmacol. Sci.

有 108 408-414 平成 19 年

Koji Ueda, Manabu Obayashi, Nakao Kojima

Proximity of metals and reducing agents to nucleic acid: Implication for the damaging mechanisms

J. Toxicol. Sci.

無 32S S79 平成 19 年

Yoshiyuki Okumura, Kenji Ogawa, Keiichi Uchiya, and Toshiaki Nikai

Characterization and primary structure of elastase inhibitor, AFLEI from Aspergillus flavus

Jpn. J. Med. Mycol.

有 48 13-18 平成 19 年

Yoshiyuki Okumura, Kenji Ogawa, Keiichi Uchiya, Yumiko Komori, Tsunemasa Nonogaki, and Toshiaki Nikai

Biological properties of elastase inhibitor, AFLEI from Aspergillus flavus

Jpn. J. Med. Mycol.

有 49 87-93 平成 19 年

Yujin Yan, Kiyofumi Yamada, Hiroyuki Mizoguchi, Yukihiro Noda, Taku Nagai, Atsumi Nitta and Toshitaka Nabeshima.

Reinforcing effects of morphine are reduced in tissue plasminogen activator (tPA)-knockout mice

Neuroscience 有 146 50-59, 平成 19 年

Kazuhiro Takuma, Ai Matsuo, Yuki Himeno,Yuki Hoshina, Ohno Y,Youko Funatsu ,Sawako Arai Hiroyuki Kamei Hiroyuki, Mizoguchi, Taku Nagai, Kouji Koike, Masaki Inoue and Kiyofumi Yamada.

17β-Estradiol attenuates hippocampal neuronal loss and cognitive dysfunction induced by chronic restraint stress in ovariectomized ratst


Kazuhiro Takuma, Hoshina, Y, Arai S, Himeno Y, Matsuo, A, Funatsu Y, Yuko Kitahara , Daisuke Ibi, Hayase M, Hiroyuki Kamei, Hiroyuki Mizoguchi, Taku Nagai, Kouji Koike, Masaki Inoue, and Kiyofumi Yamada.

Ginkgo biloba extract EGb761 attenuates hippocampal neuronal loss and cognitive dysfunction resulting from chronic restraint stress in ovariectomized rats


Masashi Ishihara, Ryoji Kojima, Mikio Ito

Influence of aging on the healing of acetic acid-induced gastric and duodenal ulcers in rats.


有 72 73-79 平成 19 年

Taku Nagai, Kazuhiro Takuma, Misato Dohniwa, Daisuke Ibi, Hiroyuki Mizoguchi, Hiroyuki Kamei, Toshitaka Nabeshima, Kiyofumi Yamada.

Repeated methamphetamine treatment impairs spatial working memory in rats: reversal by clozapine but not haloperidol.

Psychopharmacology (Berl)

有 194 21-32 平成 19 年

「脳・こころの病気」グループ

著者名論文標題雑誌名査読巻ページ発行年

Yukihiro Noda, Dayong Wang,Yu Ando Yukari Waki,Shin-nosuke

The allosteric potentiation of nicotinic acetylcholine receptors by

Biol Psychiatry

有 In press

「脳・こころの病気」グループ著者名論文標題雑誌名査読巻ページ発行年

Yamada Akira Yoshimi, Kiyofumi Yamada, Norio Ozaki, Akihiro Mouri, Toshitaka Nabeshima

galantamine ameliorates the impairment of recognition memory in mice repeatedly treated with methamphetamine: involvement of dopaminergic- extracellular signal-regulated kinase 1/2 systems

Ping Lu, Takayoshi Mamiya, Lingling Lu, Akihiro Mouri, A., Li-Bo Zou, Taku Nagai, Masayuki Hiramatsu, Takashi Ikejima and Toshitaka Nabeshima

Silibinin prevents amyloid beta peptide-induced memory impairment and oxidative stress in mice.

Br J Pharmacol

有 In press

Akihiro Mouri, Yukihiro Noda, Shigeomi Shimizu, Yoshihide, Tsujimoto, Toshitaka Nabeshima

The Role of Cyclophilin D in Learning and Memory.

Hippocampus 有 In press

Lingling Lu, Takayoshi Mamiya, Ping Lu, Kazuya Toriumi, Akihiro Mouri, Masayuki Hiramatsu, Hyoung-Chun Kim, Li-Bo Zou, Taku Nagai, Toshitaka Nabeshima

Prenatal exposure to phencyclidine produces abnormal behaviour and NMDA receptor expression in postpubertal mice

Int. J. Neuropsychopharmacology

有 In press

Hiroyuki Mizoguchi, Kazuhiro Takuma, Emiko Fukuzaki, Daisuke Ibi, Eiichi Someya, Ko-hei Akazawa, Tursun Alkam, Hiroko Tsunekawa, Akihiro Mouri, Yukihiro Noda, Toshitaka Nabeshima and Kiyofumi Yamada

Matrix metalloprotease-9 inhibition improves amyloid β-mediated cognitive impairment and neurotoxicity in mice

J Pharmacol ExpTher

有 In press

Daisuke Ibi, Atsumi Nitta, Kumiko Ishige, Xiaobo Cen, Tomohiro Ohtakara, Toshitaka Nabeshima,Yoshihisa Ito

Piccolo knockdown-induced impairments of spatial learning and long-term potentiation in the hippocampal CA1 region

J.Neurochem. 有 In press

Eun-Joo Shin, Guoying Bing, Jpng Seok Chiae, Tae Woo Kim, Jae-Hyung Bach, Kiyofumi Yamada, Toshitaka Nabeshima , Hyoung-Chun Kim

Role of Microsomal Epoxide Hydrolase in Methamphetamine-induced Drug Dependence in Mice

J Neurosci Res

有 In press

Chun-Hui Jin, Eun-Joo Shin, Jae-Bong Park, Choon-Gon Jang, Li, Zhengyi Li, Min-Soo Kim, Kyo-Hwan Koo, Hyoung Jong Yoon, Sang-Jae Park, Won-Cheol Choi, Kiyofumi Yamada, Toshitaka Nabeshima, Hyong-Chun Kim

Fustin flavonoid attenuates β-amyloid (1-42)-induced learning impairment"

J Neurosci Res

有 In press

Hiroki Ishiguro, Minori Koga, Yasue Horiuchi, Emiko Noguchi, Miyuki Morikawa, Yoshimi Suzuki, Makoto Arai, Kazuhiro Niizato, Shuji Iritani ,Masanari Itokawa, Toshiya Inada, Nakao Iwata, Norio Ozaki, Hiroshi Ujike , Hiroshi Kunuhi, Tsukasa Sasaki, Takahashi M, Yuichiro Watanabe, Toshiyuki Someya, Akisosh Kakita, Hitoshi, Takahashi Hiroyuki Nawa, Tadao Arinami

Supportive evidence for reduced expression of GNB1L in schizophrenia.

Schizophr Bull

有 In press

Heh-In Im, Akira Nakajima, Bo Gong, Xiaoli Xiong, Takayoshi Mamiya, Elliot S. Gershon, Min Zhuo, Ya-Ping Tang

Post-training dephosphorylation of eEF-2 promotes protein synthesis for memory consolidation

PLos One 有 In press

Hiroyuki Mizoguchi, Sawako Arai, Hiroyuki Koike , Daisuke Ibi, Hiroyuki Kamei , Toshitaka

Therapeutic potential of nicotine for methamphetamine-induced impairment of sensorimotor gating:

Psychopharmacology

In press


Nabeshima , Hyoung-Chun Kim , Kazuhiro Takuma, Kiyofumi Yamada

involvementof pallidotegmental neurons

Hiroyuki Koike,, Daisuke Ibi , Hiroyuki Mizoguchi, Taku Nagai , Atsumi Nitta,Kazuhiro Takuma, Toshitaka Nabeshima, Yukio Yoneda, Kiyofumi Yamada

Behavioral abnormality and pharmacologic response in social isolation-reared mice

Behav Brain Res

有 202 114-121 平成21年

Lucian Hritcu, Toshitaka Nabeshima Kainic acid lesion-induced spatial memory deficits of rats.

Cent Eur J Biol

有 4 179-185 平成21年

Nariko Arimura, Toshihide Kimura, Shinichi Nakamuta, Shinichiro Taya, Yasuhiro Funahashi, Atsushi Hattori, Akiko Shimada, Celine Menager, Saeko Kawabata, Kayo Fujii, Akihiro Iwamatsu, Rosalind A. Segal, Mitsunori Fukuda, Kozo Kaibuchi

Anterograde Transport of TrkB in Axons Is Mediated by Direct Interaction with Slp1 and Rab27

Dev Cell 有 16 675-686 平成21年

Eun-Joo Shin, Choon-Gon Jang, Guoying Bing, Dae Hun Park, Chang-Hyun,Oh, Kyo Hwan Koo, Ki Wan Oh, Kiyofumi Yamada, Toshitaka Nabeshima,Hyoung-Chun Kim

Prodynorphin gene deficiency potentiates nalbuphine-induced behavioral sensitization and withdrawal syndrome in mice

Drug Alcohol Depend

有 104 175-184 平成21年

Sawako Arai, Kazuhiro Takuma, Hiroyuki Mizoguchi, Daisuke Ibi, Taku Nagai, Hiroyuki Kamei, H., Hyoung-Chun Kim, and Kiyofumi Yamada

GABAB receptor agonist baclofen improves methamphetamine-induced cognitive deficit in mice.

Eur J Pharmacol

有 602 101-104 平成21年

Minori Koga ,Hiroki Ishiguro,Saori Yazaki ,Yasue Horiuchi , Makoto Arai Kazuhiro Niizato, Shuji Iritani ,Masanari Itokawa ,Toshiya Inada , Nakao Iwata, Norio Ozaki , Hirochi Ujike, Hirochi Kunugi, Tsukasa Sasaki, Makoto Takahashi, Yuichiro Watanabe, Toshiyuki Someya, Akiyoshi Kakita, Hitoshi Takahashi,Hiroyuki Nawa,Christian Muchardt ,Moshe Yaniv, Tadao Arinami

Involvement of SMARCA2/BRM in the SWI/SNF chromatin-remodeling complex in schizophrenia.

Hum Mol Genet

有 18(13) 2483-2494 平成21年

Yohei Iguchi, Masahisa Katsuno, Jun-ichi Niwa, Shin-ichi Yamada, Jun Sone, Masahiro Waza, Hiroaki Adachi, Fumiaki Tanaka, Koh-ichi Nagata, Nariko Arimura, Takashi Watanabe, Kozo Kaibuchi, Gen Sobue

TDP-43 Depletion Induces Neuronal Cell Damage through Dysregulation of Rho Family GTPases

J Biol Chem 有 284 22059-22066

平成21年

Takashi Watanabe, Jun Noritake, Mai Kakeno, Toshinori Matsui, Takumi Harada, Shujie Wang, Norimichi Itoh, Kazuhide Sato, Kenji Matsuzawa, Akihiro Iwamatsu, Niels Galjart and Kozo Kaibuchi

Phosphorylation of CLASP2 by GSK-3 beta regulates its interaction with IQGAP1, EB1 and microtubules.

J Cell Sci 有 122 2969-2979 平成21年

Takao Hikita, Shinichiro Taya, Yasutaka Fujino, Setsuko Taneichi-Kuroda, Kanae Ohta, Daisuke Tsuboi, Tomoyasu Shinoda,

Proteomic analysis reveals novel binding partners of dysbindin, a schizophrenia-related protein

J Neurochem 有 110 1567-1574 平成21年


Keisuke Kuroda, Yusuke Funahashi, Junko Uraguchi-Asaki, Ryota Hashimoto, Kozo KaibuchiKazutaka Mori, Mutsuki Amano, Mikito Takefuji, Katsuhiro Kato, Yasuhiro Morita, Tomoki Nishioka, Yoshiharu Matsuura, Toyoaki Murohara, Kozo Kaibuchi

Rho-kinase Contributes to Sustained RhoA Activation through Phosphorylation of p190A RhoGAP

J Biol Chem 有 284 5067-5076 平成21年

Katsuhiko Hata, Kozo Kaibuchi, Shinobu Inagaki, Toshihide Yamashita

Unc5B associates with LARG to mediate the action of repulsive guidance molecule

J Cell Biol 有 184 737-750 平成21年

Ping Lu, Takayoshi Mamiya, Lingling Lu, Akihiro Mouri, Minae Niwa, Masayuki Hiramatsu, M., Li-Bo Zou, Takashi Ikejima, Taku Nagai and Toshitaka Nabeshima

Silibinin attenuates amyloid 25-35 peptide-induced memory impairments: Implication of inducible nitric oxide synthase (iNOS) and tumor necrosis factor-α(TNF-α) in mice.

J Pharmacol Exp Ther

有 157 1270- 1277

平成21年

Shigeru Tomida, Takayoshi Mamiya, Hirotake Sakamaki, Masami Miura, Toshihiko Aosaki, Minae Niwa, Tsutomu Kameyama, Junya Kobayashi, Yuka Iwaki, Saki Imai, Akira Ishikawa, Kuniya Abe, Takashi Yoshimura, Toshitaka Nabeshima, Shizufumi Ebihara

Identification of Usp46, encoding a ubiquitin specific peptides, as a quantitative trait gene regulating mouse immobile behavior in the tail suspension test and the forced swimming test.

Nature Genetics

有 41 645-653 平成21年

Vanessa Villard, Julie Espallergues, Emeline Keller, Tursun Alkam, Atsumi Nitta, Kiyofumi Yamada, Toshitaka Nabeshima, Alexandre. Vamvakides and Tangui Maurice.

Anti-amnesic and neuroprotective effects of the aminotetrahydrofuran derivative ANAVEX1-41 against amyloid β25-35 -induced toxicity in mice.

Neuropsychopharmacology,

有 34 1552-1566 平成21年

Daisuke Ibi, Taku Nagai, Yuko Kitahara, Hiroyuki Mizoguchi, Hiroyuki Koike ,Anna Shiraki, Kazuhiro Takuma, Hiroyuki Kamei, Yukihiro Noda, Atsumi Nitta ,Toshitaka Nabeshima, Yukio Yoneda, Kiyofumi Yamada.

Neonatal polyI:C treatment in mice results in schizophrenia-like behavioral and neurochemical abnormalities in adulthood.

Neurosci Res 有 64 297-305 平成21年

Setsuko Taneichi-Kuroda, Shinichiro Taya, Takao Hikita, Yasutaka Fujino, Kozo Kaibuchi

Direct interaction of Dysbindin with the AP-3 complex via its mu subunit

Neurochem Int

有 54 431-438 平成21年

Taku Nagai, Rina Murai, Kanae Matsui, Hiroyuki Kamei, Yukihiro Noda, Hiroshi Furukawa, and Toshitaka Nabeshima

Aripiprazole ameliorates phencyclidine-induced impairment of recognition memory through dopamine D1 and serotonin 5-HT1A receptors

Psychopharmacology

有 202 315-328 平成21年

Hideki Miura, Tetsuya Shirokawa, Kenichi Isobe, Norio Ozaki

Shifting the balance of brain tryptophan metabolism elicited by isolation housing and systemic administration of lipopolysaccharide in mice.

Stress 有 12 (3) 206-214 平成21年

有村奈利子、貝淵弘三. TrkBの順行性軸索内輸送はSlp1と

Rab27により制御されている.

細胞工学無 28 932-933 平成21年

野田幸裕、毛利彰宏、脇由香里、鍋臨床知見に基づいた統合失調症日本神経精無 29 47-53 平成21年


島俊隆動物モデルを作製するために-統合

失調症モデル作製のため、基礎研

究者が臨床医に望むこと-

神薬理学雑

誌

日比陽子，新田淳美，鍋島俊隆，山

田清文

脳由来神経栄養因子およびグリア細胞由来神経栄養因子と神経精

神疾患との関係

日本神経精

神薬理学雑

誌

有 29 平成21年

永井拓, 鍋島俊隆, 山田清文. 統合失調症における発症脆弱性遺

伝子と創薬. 分子精神医

学無 9 30-37 平成21年

野田幸裕、吉見陽、脇由香里、亀

井浩行、安藤雄、毛利彰宏、鍋島俊

隆

情動・認知障害モデル動物の発症

脆弱性に及ぼす環境強化の影響-情動・認知障害モデル動物の機能

評価-

名城大学総

合研究所紀

要

無 14 111-114 平成21年

Kunihiro Kawashima, Taro,Kishi Masashi Ikeda, Tsuyoshi Kitajima, Yoshio Yamanouchi, Yoko Kinoshita, Nagahide Takahashi, Shinichi Saito, Kazuataka Ohi, Yuka Yasuda, Ryota Hashimoto, Masatoshi Takeda, Toshiya Inada, Norio Ozaki, Nakao Iwata

No association between tagging SNPs of SNARE complex genes (STX1A, VAMP2 and SNAP25) and schizophrenia in a Japanese population.

Am J Med Genet B Neuropsychiatr Genet

有 147B 1327-1331 平成20年

Yoshihito Ito, Shinnosuke Yamada, Nagahide Takahashi, Shinichi Saito, Akira Yoshimi, Toshiya Inada, Yukihiro Noda, and Norio Ozaki

No association between the protein tyrosine phosphatase, receptor-type, Z polypeptide 1 (PTPRZ1) gene and schizophrenia in the Japanese population


有 147B 1013-1018 平成20年

Masaru Yamamoto, Servio H. Ramirez, Shinji Sato, Tomomi Kiyota, Ronald L. Cerny, Kozo Kaibuchi, Yuri Persidsky, Tsuneya Ikezu

Phosphorylation of claudin-5 and occludin by Rho kinase in brain endothelial cells

Am J Pathol 有 172 521-533 平成20年

Taro Kishi, Masashi Ikeda, Tsuyoshi Kitajima, Yoshio Yamanouchi, Yoko Kinoshita, Kunihiro Kawashima, Toshiya Inada, Mutsuo Harano, Tokutaro Komiyama, Toruoru Hori, Mitsuhiko Yamada, Masaomi, Ichiro Sora, Masaomi Iyo Yoshimoto Sekine, Norio Ozaki, Hiroshi Ujike, Nakao Iwata

Prostate apoptosis response 4 gene is not associated with methamphetamine-use disorder in the Japanese population.

Ann N Y Acad Sci

有 1139 83-88 平成20年

Taro Kishi, Masashi Ikeda, Tsuyoshi Kitajima, Yoshio Yamanouchi, Yoko Kinoshita, Kunihiro Kawashima, Toshiya Inada, Mutsuo Harano, Tokutaro Komiyama, Toruoru Hori, Mitsuhiko Yamada, Masaomi, Ichiro Sora, Masaomi Iyo Yoshimoto Sekine, Norio Ozaki, Hiroshi Ujike, Nakao Iwata

Glutamate cysteine ligase modifier (GCLM) subunit gene is not associated with methamphetamine-use disorder or schizophrenia in the Japanese population.

Ann N Y Acad Sci

有 1139 63-69 平成20年

Yoko Kinoshita, Masashi,Ikeda Hiroshi Ujike, Tsuyoshi Kitajima, Yoshio Yamanouchi, Blanko Aleksic, Taro Kishi, Kunihiro Kawashima, Ohkouchi T, Norio Ozaki, Toshiya Inada, Mutsuo Harano, Tokutaro Komiyama, Toru Hori, Mitsuhiko Yamada, Sekine Yoshimoto, Masaomi Iyo, Ichiro Sora, Nakao Iwata

Association study of the calcineurin A gamma subunit gene (PPP3CC) and methamphetamine-use disorder in a Japanese population.

Ann N Y Acad Sci

有 1139 57-62 平成20年

Norikazu Ezaki, Kazuhiko Nakamura, Yoshimoto Sekine, Isami Thanseem, Ayyappan Anitha , Yasuhide Iwata, Masayoshi Kawai , Kiyokasu Takebayashi,

Short allele of 5-HTTLPR as a risk factor for the development of psychosis in Japanese methamphetamine

Ann N Y Acad Sci

有 1139 49-56 平成20年


Katsuaki Suzuki, Nori Takei, Masaomi Iyo, Toshiya Inada , Iwata Nakao, Mutsuo Harano, Tokutaro Komiyama, Mitsuhiko Yamada, Ichiro Sora, Hiroshi Ujike, Norio Mori Taro Kishi, Masashi Ikeda, Tsuyoshi Kitajima, Yoshio Yamanouchi, Yoko Kinoshita, Kunihiro Kawashima, Toshiya Inada, Mutsuo Harano, Tokutaro Komiyama, Toru Hori, Mitsuhiko Yamada, Masaomi Iyo, Ichiro Sora, Yoshimoto Sekine, Norio Ozaki, Hiroshi Ujike, Nakao Iwata

Alpha4 and beta2 subunits of neuronal nicotinic acetylcholine receptor genes are not associated with methamphetamine-use disorder in the Japanese population.

Ann N Y Acad Sci

有 1139 70-82 平成20年

Uhl George R, Tomasu Dragon, Qing-Rong Liu , Catherine Johnson ,Dona Walther , Tokutaro Komiyama, Mutsuo Harano, Yoshimo Sekine, Toshiya Inada, Norio Ozaki, Masaomi Iyo, Nakao,Iwata Mitsuhiko Yamada, Ichiro Sora, Hsing-Chen Liu, Hiroshi Ujike, Shih-ku Lin

Genome-wide association for methamphetamine dependence: convergent results from 2 samples.

Arch Gen Psychiatry

有 65（３） 345-355 平成20年

Makiko Kishimoto, Hiroshi Ujike, Yuko Okahisa, Tatsuya Kotaka, Manabu Takaki, Masafumi Kodama, Toshiya Inada, Mitsuhiko Yamada, Naohisa Uchimura, Nakao Iwata, Ichiro Sora, Masaomi Iyo, Norio Ozaki, Shigetoshi Kuroda

The Frizzled 3 gene is associated with methamphetamine psychosis in the Japanese population.

Behav Brain Funct

有 15(4) 37 平成20年

Alkam Trusun., Atsumi Nitta., Hiroyuki Mizoguchi., Kuniaki Saito, Michiomi Seishima, Akio Itoh. ,Kiyofumi Yamada., Toshitaka Nabeshima.

Restraining tumor necrosis factor-alpha by thalidomide prevents the Abeta-induced impairment of recognition memory in mice.

Behav Brain Res

有 189 100-106 平成20年

Hiroko Tsunekawa., Yukihiro Noda., Masayuki Miyazaki., F Yoneda, Toshitaka Nabeshima.:

(R)-(-)-1-(benzofuran-2-yl)-2-propylaminopentane hydrochloride [(-)-BPAP] in animal models of mood disorders.

Behav Brain Res

有 189 107-116 平成20年

Hiroko Tsunekawa., Yukihiro Noda., Akihiro Mouri., F Yoneda, Toshitaka Nabeshima.

Synergistic effects of selegiline and donepezil on cognitive impairment induced by amyloid beta (25-35)

Behav Brain Res

有 194 224-232 平成20年

Makiko Kishimoto, Hiroshi Ujike, Yasuko Motohashi, Yuji Tanaka, Yuko Okahisa, Tatsuya Kotaka, Mutsuo Harano, Toshiya Inada, Mitsuhiko Yamada, Tokutaro Komiyama, Toru Hori, Yoshimoto Sekine, Nakao Iwata, Ichiro Sora, Masaomi Iyo, Norio Ozaki, Shigetoshi Kuroda

The Dysbindin Gene (DTNBP1) Is Associated with Methamphetamine Psychosis.

Biol Psychiatry

有 63 (2) 191-196 平成20年

Deng Xiangdong, Noriaki,Sagata Naoko Takeuchi, Masami Tanaka, Hideaki Ninomiya, Nakao Iwata, Norio Ozaki, Hiroki Shibata, Yasuyuki Fukumaki

Association study of polymorphisms in the neutral amino acid transporter genes SLC1A4, SLC1A5 and the glycine transporter genes SLC6A5, SLC6A9 with schizophrenia.

BMC Psychiatry

有 18(8) 58 平成20年

Takashi Watanabe, Shujie Wang, Mai Kakeno, Jiro Usukura, Kozo Kaibuchi

Ultrastructural Study of Rac1 and Its Effectors beneath the Substratum-Facing Membrane

Cell Struc Func

有 33 101-107 平成20年

Ayako Nunokawa, Yuichiro Watanabe, Hideaki Kitamura, Naoshi Kaneko, Tadao

Large-scale case-control study of a functional polymorphism in the

Clin Neurosci 有 62(2) 239-240 平成20年


Arinami, Hiroshi Ujike, Toshiya Inada, Nakao Iwata, Hiroshi Kunugi, Masanori Itokawa, Norio Ozaki, Toshiyuki Someya

glutamate receptor, metabotropic 3 gene in patients with schizophrenia. Psychiatry.

Masanori Nakayama , Takaki M Goto, Masayuki Sugimoto, Takashi Nishimura, Takafumi Shinagawa, Sigeo Ohno, Mutsuki Amano, Kozo Kaibuchi

Rho-kinase phosphorylates PAR-3 and disrupts PAR complex formation


Shigeko Yamashiro, Yoshihiko Yamakita, Go Totsukawa, Hidemasa Goto, Kozo Kaibuchi, Masaaki Ito, David J. Hartshorne, Fumio Matsumura

Myosin phosphatase-targeting subunit 1 regulates mitosis by antagonizing polo-like kinase 1


Toshihiro Iwasaki, Akira Katsumi, Hitoshi Kiyoi, Ryohei Tanizaki, Yuichi Ishikawa, Kazutaka Ozeki, Miki Kobayashi, Akihiro Abe, Tadashi Matsushita, Takashi Watanabe, Mutsuki Amano, Tetsuhito Kojima, Kozo Kaibuchi, Tomoki Naoe

Prognostic implication and biological roles of RhoH in acute myeloid leukaemia

Eur J Haematol

有 81 454-460 平成20年

Kunihiro Iwamoto, Masahiro Takahashi, Yukako Nakamura, Yukiko Kawamura, Ryoko Ishihara, Yuji Uchiyama, Kazutoshi Ebe, Akiko Noda, Yukihiro Noda, Keizo Yoshida, Tetsuya Iidaka, Norio Ozaki

The effects of acute treatment with paroxetine, amitriptyline, and placebo on driving performance and cognitive function in healthy Japanese subjects: A double-blind crossover trial

Hum Psychopharmacol

有 23 399-407 平成20年

Masashi Ikeda, Takao Hikita, Shinichiro Taya, Junko Uraguchi-Asaki, Kazuhito Toyo-oka, Anthony Wynshaw-Boris, Hiroshi Ujike, Toshiya Inada, Keizo Takao, Tsuyoshi Miyakawa, Norio Ozaki, Kozo Kaibuchi, Nakao Iwata

Identification of YWHAE, a gene encoding 14-3-3epsilon, as a possible susceptibility gene for schizophrenia

HumMolGenetics

有 17 3212-3222 平成20年

Ryohei Tanizaki, Akira Katsumi, Hitoshi Kiyoi, Shinji Kunishima, Toshihiro Iwasaki, Yuichi Ishikawa, Miki Kobayashi, Akihiro Abe, Tadashi Matsushita, Takashi Watanabe, Tetsuhito Kojima, Kozo Kaibuchi, Seiji Kojima, Tomoki Naoe

Mutational analysis of SOS1 gene in acute myeloid leukemia

Int J Hem 有 88 460-462 平成20年

Branko Aleksic, Masashi Ikeda Ryoko Ishihara, Schinichi Saito, Toshiya Inada, Nakao Iwata, Norio Ozaki

No association between the oligodendrocyte-related gene PLP1 and schizophrenia in the Japanese population.

J Hum Genet 有 53 (9) 863-866 平成20年

Nitta Mari, Narita Tomotaku, Umeda Kazunori, Hattori Miho,Naitoh Hiroshi, Iwata Nakao

Influence of negative cognition on the parental bonding instrument (PBI) in patients with major depression.

J Nerv Ment Dis

有 196(3) 244-246 平成20年

Taro Kishi, Masashi Ikeda, Tsuyoshi Kitajima, Yoshio Yamanouchi, Yoko Kinoshita, Kunihiro Kawashima, Tomo Ohkochi, Toshiya Inada, Norio Ozaki, Nakao Iwata

Genetic association analysis of tagging SNPs in alpha4 and beta2 subunits of neuronal nicotinic acetylcholine receptor genes (CHRNA4 and CHRNB2) with schizophrenia in the Japanese population.

J Nral Transm 有 115 1457-1461 平成20年

Daisuke Ibi, Kazuhiko Takuma, Koike H, Hiroyuki Mizoguchi, Tsuritani K, Kuwahara Y, Hiroyuki Kamei, Taku Nagai, Yoneda Y, Toshitaka Nabeshima, Kiyofumi Yamada.

Social isolation rearing-induced impairment of the hippocampal neurogenesis is associated with deficits in spatial memory and emotion-related behaviors in



juvenile mice. Minae Niwa , Atsumi Nitta, Cen XB, Kiyoyuki Kitaichi, Norio Ozaki, Kiyofumi Yamada, Toshitaka Nabeshima

A novel molecule 'shati' increases dopamine uptake via the induction of tumor necrosis factor-alpha in pheochromocytoma-12 cells.


Alkam Trusun, Atsumi Nitta, Hiroyuki Mizoguchi, Akio Itoh, Rina Murai, Taku Nagai, Kiyofumi Yamada, Toshitaka Nabeshima.

The extensive nitration of neurofilament light chain in the hippocampus is associated with the cognitive impairment induced by amyloid beta in mice.


有 327, 137-147 平成20年

Siriporn Patrakitkomjorn, Daiki Kobayashi, Takashi Morikawa, Masayo Morifuji Wilson, Nobuyuki Tsubota, Atsushi Irie, Tatsuya Ozawa, Masashi Aoki, Nariko Arimura, Kozo Kaibuchi, Hideyuki Saya, and Norie Araki

Neurofibromatosis type 1 (NF1) tumor suppressor, neurofibromin, regulates the neuronal differentiation of PC12 cells via its associating protein, CRMP-2

J Biol Chem 有 283 9399-9413 平成20年

Ayumi Fukakusa, Taku Nagai, Hiroyuki Mizoguchi, Noboru Otsuka, N., Haruhide Kimura, Hiroyuki Kamei, Hyoung-Chun Kim, Toshitaka Nabeshima, Kazuhiro Takuma and Kiyofumi Yamada

Role of tissue plasminogen activator in the sensitization of methamphetamine-induced dopamine release in the nucleus accumbens.


Jun Kawanokuchi, Kouki Shimizu, Atsumi Nitta, Kiyofumi Yamada, Tetsuya Mizuno , Hideyuki Takeuchi, Akio Suzumura.

Production and functions of IL-17 in microglia.

J Neuroimmunol

有 194 54-61 平成20年

Tomiyasu Murata, Masaru Tsuboi, Naoshi Koide, Susumu Kohno, Kiyomi Hikita, Norio Kaneda

Neuronal differentiation elicited by glial cell line-derived neurotrophic factor and ciliary neurotrophic factor in adrenal chromaffin cell line tsAM5D immortalized with temperature-sensitive SV40 T-antigen

J Neurosci Res

有 86 1694-1710 平成20年

Tomiyasu Murata, Masataka Itoigawa, Chihiro Ito, Keisuke Nakao, Masaru Tsuboi, Norio Kaneda, Hiroshi Furukawa

Induction of apoptosis in human leukaemia HL-60 cells by furanone-coumarins from Murraya siamensis

J Pharm Pharmacol

有 60 385-389 平成20年

Hiroyuki Mizoguchi., Kiyofumi Yamada and Toshitaka Nabeshima.

Neuropsychotoxicity of Abused Drugs : Involvement of Matrix Metalloproteinase-2 and -9 and Tissue Inhibitor of Matrix Metalloproteinase-2 in Methamphetamine- Induced Behavioral Sensitization and Reward in Rodents.

J Pharmacol Sci

有 106 9-14 平成20年

Shin EJ, Lee PH, Kim HJ, Toshitaka Nabeshima, Kim HC.

Neuropsychotoxicity of abused drugs: potential of dextromethorphan and novel neuroprotective analogs of dextromethorphan with improved safety profiles in terms of abuse and neuroprotective effects.

J Pharmacol Sci

有 106 22-27 平成20年

Ayumi Fukakusa, Hiroyuki Mizoguchi, Hiroyuki Koike , Toshitaka Nabeshima, Kazuhiko Takuma, Kiyofumi Yamada.:

Tissue plasminogen activator is not involved in methamphetamine-induced neurotoxicity.

J Pharmacol Sci

有 106 321-324 平成20年

Taku Nagai, Toshitaka Nabeshima, and Kiyofumi Yamada

Basic and Translational Research on Proteinase-Activated Receptors: Regulation of nicotine reward by tPA-plasmin system via proteinase-activated receptor1

J Pharmacol Sci

有 108 408-414 平成20年


Masahiko Sugimoto, Akihito Inoko, Takashi Shiromizu, Masanori Nakayama, Peng Zou, Shigenobu Yonemura, Yuko Hayashi, Ichiro Izawa, Mikio Sasoh, Yukitaka Uji, Kozo Kaibuchi, Tohru Kiyono, Masaki Inagaki

The keratin-binding protein Albatross regulates polarization of epithelial cells


Takaaki Enomoto, Yukihiro Noda, Toshitaka Nabeshima.

Phencyclidine and genetic animal models of schizophrenia developed in relation to the glutamate hypothesis.

Methods Find Exp Clin Pharmacol

有 29 291-301 平成20年

Nobuyuki Yamasaki , Motoko Maekawa ,Katsunori Kobayashi ,Yasushi Kajii , Jun Maeda, Miho Soma , Keizo Takao ,Koichi Tanda , Koji Ohira , Keiko Toyama ,Kouji Kanzaki ,Kohji Fukunaga ,Yusuke Sudo , Hiroshi Ichinose, Masashi Ikeda , Nakao Iwata, Norio Ozaki

Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disorders.

Mol Brain 有 1 (1) 6 平成20年

Go Kuratomi ,Kunihiro Iwamoto, Miki Bundo, Ichiro Kusumi, Nobumasa Kato ,Nakao Iwata, Norio Ozaki, Tadafumi Kato

Aberrant DNA methylation associated with bipolar disorder identified from discordant monozygotic twins.

Mol Psychiatry

有 13 429-41 平成20年

Cen XB, Atsumi Nitta.,Daisuke Ibi, Zhao Y., Minae Niwa, K Taguchi., M. Hamada, Yoshihisa Ito., Yasumoto Ito, Wang Li, Toshitaka Nabeshima.

Identification of Piccolo as a Regulator of Behavioral Plasticity and Dopamine Transporter Internalization: Piccolo as a Regulator of Behavioral Plasticity and DAT Internalization.

Mol Psychiatory

有 13 451-463 平成20年

Xiaofei Ji, Nagahide Takahashi, Aleksic Branko, Ryoko Ishihara, Taku Nagai, Akihiro Mouri, Shinichi Saito, Nobuhisa Maeno, Toshiya Inada and Norio Ozaki

An association between serotonin receptor 3B gene (HTR3B) and treatment-resistant schizophrenia (TRS) in a Japanese population.

Nagoya J Med Sci

有 70 11-17 平成20年

Sawako Arai, Kazuhiro Takuma, Hiroyuki Mizoguchi, Daisuke Ibi, Taku Nagai, Kenji Takahashi, Hiroyuki Kamei, Toshitaka Nabeshima and Kiyofumi Yamada

Involvement of pallidotegmental neurons in methamphetamine- and MK-801-induced impairment of prepulse inhibition of the acoustic startle reflex in mice: reversal by GABAB receptor agonist baclofen.


有 33 3164-3175 平成20年

Shinichi Saito ,Nagahide Takahashi , Nobuhisa Maeno , Yoshihito Ito ,Branko Aleksic, Hinako Usui ,Tetuya Iidaka , Toshiya Inada , Norio Ozaki

An association study of tachykinin receptor 3 gene with schizophrenia in the Japanese population.

Neuroreport 有 19 (4) 471-473 平成20年

Kyohei Otani, Hiroshi, Ujike Ayumi Sakai, Yuko Okahisa, Tatsuya Kotaka, Toshiya Inada, Mutsuou Harano, Tokutaro Komiyama, Toru Hori, Mitsuhiko Yamada, Yoshimoto Sekine, Nakao Iwata , Masaomi Iyo, Ichiro Sora , Norio Ozaki, Shigetoshi Kurosa

Reduced CYP2D6 activity is a negative risk factor for methamphetamine dependence.

Neurosci Lett 有 434(1) 88-92 平成20年

Tsutomu Takahashi, Michio Suzuki,Masahiko Tsunoda, Yukiko Kawamura, Nagahide Takahashi, Hiroshi Tsuneki ,Yasuhiro Kawasaki , Shi-Yu Zhou, Soushi Kobayashi,

Association between the brain-derived neurotrophic factor Val66Met polymorphism and brain morphology in a Japanese sample of schizophrenia and healthy

Neurosci Lett 有 435 34-39 平成20年


Toshiyasu Sasaoka, Hikaru Seto, Masayoshi Kurachi, Norio Ozaki

comparisons.

Xiaofei Ji, Nagahide Takahashi ,Shinichi Saito ,Ryoko Ishihara, Nobuhisa Maeno, Toshiya Inada, Norio Ozaki

Relationship between three serotonin receptor subtypes (HTR3A, HTR2A and HTR4) and treatment-resistant schizophrenia in the Japanese population.


Ohtsuki Tsuyuka, Horiuchi Yasue, Koga Minori, Ishiguro Hiroki, Inada Toshiya, Iwata Nakao, Ozaki Norio, Ujike Hiroshi, Watanabe Yuichiro, Someya Toshiyuki, Arinami Tadao

Association of polymorphisms in the haplotype block spanningthe alternatively spliced exons of the NTNG1 gene at 1p13.3 with schizophrenia in Japanese populations.


Tomiyasu Murata, Naoshi Koide, Masaru Tsuboi, Susumu Kohno, Kiyomi Hikita, Norio Kaneda

Autocrine TGF-β signaling is required for the GDNF/CNTF-induced neuronal differentiation of adrenal chromaffin tsAM5D cells expressing temperature-sensitive SV40 T-antigen


Yoshihito Ito, Yukako Nakamura, Nagahide Takahashi, Shinichi Saito, Branko Aleksic, Nakao Iwata, Toshiya Inada, Norio Ozaki

A genetic association study of the FXYD domain containing ion transport regulator 6 (FXYD6) gene, encoding phosphohippolin, in susceptibility to schizophrenia in a Japanese population.


Taro Kishi, Tsuyoshi Kitajima , Masashi Ikeda, Yoshio Yamanouchi, Yoko Kinoshita, Kunihiro Kawashima, Tomo Okochi, Norio Ozaki, Nakao Iwata

Association analysis of nuclear receptor Rev-erb alpha gene (NR1D1) with mood disorders in the Japanese population.

Neurosci Res 有 62(4) 211-215 平成20年

Yoshito Kanazawa, M Makino, Y Morishima , Kiyofumi Yamada, Toshitaka Nabeshima, , Y Shirasaki.

Degradation of PEP-19, a calmodulin-binding protein, by calpain is implicated in neuronal cell death induced by intracellular Ca2+ overload.

Neuroscience 有 154 473-481 平成20年

Toshiya Inada, Minori Koga, Hiroki Ishiguro, Yasue Horiuchi, Aoi Syu, Takahashi Yoshio, Nagahide Takahashi, Norio Ozaki, Tadao Arinami

Pathway-based association analysis of genome-wide screening data suggest that genes associated with the gamma-aminobutyric acid receptor signaling pathway are involved in neuroleptic-induced, treatment-resistant tardive dyskinesia.

Pharmacogenet Genomics

有 18 (4) 317-323 平成20年

Masashi Ikeda, Yoshio Yamanouchi, Yoko Kinoshita, Tsuyoshi, Kitajima Reiji Yoshimura, Shuji, Hashimoto O'Donovan Michel C, Jun Nakamura, Norio Ozaki, Nakao Iwata

Variants of dopamine and serotonin candidate genes as predictors of response to risperidone treatment in first-episode schizophrenia.

Pharmacogenomics

有 9(10) 1437-1444 平成20年

Tsutomu Takahashi, Michio Suzuki, Masahiko Tsunoda, Yukiko Kawamura, Nagahide Takahashi, Nobuhisa Maeno, Yasuhiro Kawasaki, Shi-Yu Zhou, Hirofumi Hagino, Lisha

The association of genotypic combination of the DRD3 and BDNF polymorphisms on the adhesio interthalamica and medial temporal lobe structures.

Prog Neuropsychopharmacol Biol Psychiatry

有 32 (5) 1236-1242 平成20年


Niu, Hiroshi Tsuneki, Shoushi Kobayashi, Toshiyasu Sasaoka, Hikaru Seto, Masayoshi Kurachi Hiroki Ishiguro, Keiko Imai, Minori, Koga Yasue ,Horiuchi, Toshiya Inada, Nakao Iwata, Norio Ozaki, Hiroshi Ujike, Masanori Itokawa, Hiroshi Kunugi, Tsukasa Sasaki, Yuichiro Watanabe, Toshiyuki Someya, Tadao Arinami

Replication study for associations between polymorphisms in the CLDN5 and DGCR2 genes in the 22q11 deletion syndrome region and schizophrenia.

Psychiatr Genet

有 18(5) 255-256 平成20年

Kunihiro Iwamoto, Yukiko Kawamura, Masahiro Takahashi, Yuji Uchiyama, Kazutoshi Ebe, Keizo Yoshida, Tetsuya Iidaka, Yukihiro Noda, and Norio Ozaki

Plasma amitriptyline level after acute administration, and driving performance in healthy volunteers

Psychiatry Clin Neurosci

有 62 610-616 平成20年

Akira Yoshimi, Nagahide Takahashi, Sinichi Saito, Yoshihito Ito, Branko Aleksic, Hinako Usui, Yukiko Kawamura, Yukari Waki, Takeo Yoshikawa, Tadafumi Kato, Nakao Iwata, Toshiya Inada, Yukihiro Noda and Norio Ozaki

Genetic analysis of the gene coding for DARPP-32 (PPP1R1B) in Japanese patients with schizophrenia or bipolar disorder

Schizophr Res 有 100 334-341 平成20年

Ikeda Masashi, Takahashi Nagahide, Saito Shiniuchi, Aleksic Blanko, Watanabe Yuichiro, Nunokawa Ayako, Yamanouchi Yoshio,Kitajima Tsuyoshi, Kinoshita Yoko, Kishi Taro, Kawashima Kunihiro, Hashimoto Ryota, Ujike Hiroshi, Inada Toshiya, Someya Toshiyuki,Takeda Masatoshi, Ozaki Norio, Iwata Nakao

Failure to replicate the association between NRG1 and schizophrenia using Japanese large sample.

Schizophr Res 有 101(1-3)

1-8 平成20年

Ohtsuki Tsuyuka, Koga Minori, Ishiguro Hiroki, Horiuchi Yasue, Arai Makoto, Niizato Kazuhiro, Itokawa Masanori, Inada Toshiya, Iwata Nakao, Iritani Shyuji, Ozaki Norio, Kunuhi Hiroshi, Ujike Hiroshi, Watanabe Yuichiro, Someya Toshiyuki, Arinami Tadao

A polymorphism of the metabotropic glutamate receptor mGluR7 (GRM7) gene is associated with schizophrenia.

Schizophr Res 有 101(1-3)

9-16 平成20年

飯高哲也扁桃体-情動脳と社会脳扁桃体

のニューロイメージング ClinNeurosci 無 26（4） 431-434 平成20年

天野睦紀、貝淵弘三 Rho-キナーゼ阻害剤細胞工学無 27 40-43 平成20年

中山雅敬、貝淵弘三 RhoA/Rho-キナーゼによる細胞遊

走・細胞極性制御機構細胞工学無 27 370-371 平成20年

永井拓、山田清文ニコチン依存における組織プラスミ

ノーゲン活性化因子の役割日本アルコー

ル・薬物医学

会雑誌

有 43 151-157 平成20年

永井拓、田熊一敞、鍋島俊隆、山田

清文

組織プラスミノーゲン活性化因子に

よる依存性薬物の報酬効果の制

御.

日本神経精

神薬理学雑

誌

有 28 1-6 平成20年

飯高哲也ミニレビュー：情動とストレス脆弱性

を脳画像で探る―扁桃体の機能を

中心として―

日本神経精

神薬理学雑

誌

無 28 185-188 平成20年

古関竹直、毛利彰宏、村井里菜、永

井拓、野田幸裕、鍋島俊隆

難治性統合失調症の動物モデルと

治療薬開発. 脳と精神の医

学有 19 31-40 平成20年

吉見陽、野田幸裕、齋藤真一、尾崎

紀夫

統合失調症の病態と新薬開発の

動向脳と精神の医

学無 19 165-172 平成20年

飯高哲也特集/ｆMRIと精神医学ｆMRIでみ臨床精神医無 37（6） 805-810 平成20年


る精神疾患の中間表現型学 Albalushi Talal, Yasue Horiuchi Hiroki Ishiguro, Minori Koga, Toshiya Inada, Nakao Iwata, Norio Ozaki, Hiroshi Ujike, Yuichiro Watanabe, Toshiyuki Someya, Tadao Arinami

Replication study and meta-analysis of the genetic association of GRM3 gene polymorphisms with schizophrenia in a large Japanese case-control population.


有 19 392-396 平成19年

Deng Xiangdong,, hiroki Shibata, Naoko Takeuchi, Rachi S, Sakai M, Hideaki Ninomiya, Nakao,Iwata Norio Ozaki, Yasuyuki Fukumaki

Association study of polymorphisms in the glutamate transporter genes SLC1A1, SLC1A3, and SLC1A6 with schizophrenia.


有 144B 271-278 平成19年

Taro Kishi, Masashi Ikeda, Tsuyoshi Kitajima, Tatsuyo Suzuki, Yoshio Yamanouchi, Yoko Kinoshita, Kunihiro Kawashima, Norio,Ozaki Nakao Iwata

No association between prostate apoptosis response 4 gene (PAWR) in schizophrenia and mood disorders in a japanese population.


有 147 531-534 平成19年

Matsuzawa Daisuke, Hashimoto Kenji, Miyatake Ryosuke, Shirayama Yukihiko, Shimizu Eiji, Maeda Kazuhisa, Suzuki Yoshimi, Mashimo Yoichi, Sekine Yoshimoto, Inada Toshiya, Ozaki Norio,Iwata Nakao, Harano Mutsuo, Komiyama Tokutaro, Yamada Mitsuhiko, Sora Ichiro,Ujike Hiroshi, Hata A, Sawa A,Iyo Masaomi.

Identification of functional polymorphisms in the promoter region of the human PICK1 gene and their association with methamphetamine psychosis.

Am J Psychiatry

有 164(7) 1105-1114 平成19年

Dayoung Wang, Yukihiro Noda, Hiroko Tsunekawa, Zhou Yuan, Masayuki Miyazaki, Senzaki K, Toshitaka Nabeshima.:

Behavioural and neurochemical features of olfactory bulbectomized rats resembling depression with comorbid anxiety.

Behav Brain Res

有 178 262-273 平成19年

Minae Niwa, Atsumi Nitta, Liya Shen, Yukihiro Noda, Toshitaka Nabeshima

Involvement of glial cell-line derived neurotrophic factor inhibitory effects of a hydorophobic dipeptide Leu-Ile on morphine-induced sensitization and rewarding effects.

Behav Brain Res

有 179 167-171 平成19年

Alkam Truxun, Atsumi Nitta, Hiroyuki Mizoguchi, Akio Itoh, Toshitaka Nabeshima

A natural scavenger of peroxynitrites, rosmarinic acid, protects against impairment of memory induced by Abeta(25-35).

Behav Brain Res

有 180 139-145 平成19年

Rina Murai, Yukihiro Noda, Matsui K, Hiroyuki Kamei, Akihiro Mouri, Matsuba Kazuhisa, Atsumi Nitta, Furukawa H, Toshitaka Nabeshima.:

Hypofunctional glutamatergic neurotransmission in the prefrontal cortex is involved in the emotional deficit induced by repeated treatment with phencyclidine in mice: implications for abnormalities of glutamate release and NMDA-CaMKII signaling.

Behav Brain Res

有 180 152-160 平成19年

Masayuki Sugimoto, Masanori Nakayama, Takaaki M. Goto, Mutsuki Amano, Kimihiro Komori, Kozo Kaibuchi

Rho-kinase phosphorylates eNOS at threonine 495 in endothelial cells

Biochem Biophys Res Commun

有 361 462-467 平成19年

Mikito Takefuji, Kazutaka Mori, Yasuhiro Morita, Nariko Arimura, Takashi Nishimura, Masanori Nakayama, Mikio Hoshino, Akihiro Iwamatsu, Toyoaki Murohara, Kozo Kaibuchi, Mutsuki Amano

Rho-kinase modulates the function of STEF, a Rac GEF, through its phosphorylation

Biochem Biophys Res Commun

有 355 788-794 平成19年


Minae Niwa, Atsumi Nitta, Yuichiro Yamada, Akira Nakajima, Kuniaki Saito, Mitsuru Seishima, Liya Shen, Yukihiro Noda, Shoei Furukawa, and Toshitaka Nabeshima.

An inducer for glial cell line-derived neurotrophic factor and tumor necrosis factor-α protects against methamphetamine-induced rewarding effects and sensitization.

Biol Psychiatry

有 61 890-901 平成19年

Kenji Takahashi, Taku Nagai, Hiroyuki Kamei, Kenji Maeda, Takahiro Matsuya, Sawako Arai, Hiroyuki Mizoguchi, Yukio Yoneda, Toshitaka Nabeshima, Kazuhiro Takuma and Kiyofumi Yamada

Neural circuits containing pallidotegmental GABAergic neurons are involved in the prepulse inhibition of the startle reflex in mice.

Biol Psychiatry

有 62 148-157 平成19年

Minae Niwa, Atsumi Nitta, Yuichiro Yamada, Akira Nakajima, Kuniaki Saito, Mitsuru Seishima, Yukihiro Noda, and Toshitaka. Nabeshima.

Tumor necrosis factor-α and its inducer inhibit morphine-induced rewarding effects and sensitization.

Biol Psychiatry

有 62 658-668 平成19年

Takashi Nishimura, Kozo Kaibuchi Numb controls integrin endocytosis for directional cell migration with aPKC and PAR-3


Akihiro Mouri, Yukihiro Noda, Hara H, Hiroyuki Mizoguchi, Tabira T, Toshitaka Nabeshima.:

Oral vaccination with a viral vector containing Abeta cDNA attenuates age-related Abeta accumulation and memory deficits without causing inflammation in a mouse Alzheimer model.

FASEB J 有 21 2135-2148 平成19年

Hiroshi Qadota, Makiko Inoue, Takao Hikita, Mathias K?ppen, Jeffrey D. Hardin, Mutsuki Amano, Donald G. Moerman, Kozo Kaibuchi

Establishment of a tissue-specific RNAi system in C-elegans

Gene 有 400 166-173 平成19年

Tomita Yasuki, Ikeda Masashi, Mutoh Hironori, Inada Toshiya, Iwata Nakao, Ozaki Norio,Honda Hiroyuki

Association study between Apolipoprotein L and schizophrenia by exhaustive and rule-based combination analysis for identification of multilocus interactions.

J Biosci Bioeng

有 103(4) 303-310 平成19年

Dominique T. Brandt, Sabrina Marion, Gareth Griffiths, Takashi Watanabe, Kozo Kaibuchi, Robert Grosse

Dia1 and IQGAP1 interact in cell migration and phagocytic cup formation


Branko Aleksic, Ryoko Ishihara, Nagahide Takahashi, Nobuhisa Maeno, Xiaofei Ji ,Shinichi Saito , Toshiya Inada , Norio Ozaki

Gap junction coding genes and schizophrenia: a genetic association study.

J Hum Genet 有 52（6） 488-501 平成19年

Hiroyuki Mizoguchi, Kiyofumi Yamada, Minae Niwa, Akihiro Mouri, Tomoko Mizuno , Yukihiro Noda, Atsumi Nitta, Akio Itoh , Yoshiko Banno , Toshitaka Nabeshima.

Reduction of methamphetamine-induced sensitization and reward in matrix metalloproteinase-2 and -9-deficient mice.


Mina Ito, Taku Nagai, Hiroyuki Mizoguchi, Ayumi Fukakusa, Yutaka Nakanishi, Hiroyuki Kamei, Toshitaka Nabeshima, Kazuhiro Takuma and Kiyofumi Yamada

Possible involvement of protease-activated receptor-1 in the regulation of morphine-induced dopamine release and hyperlocomotion by the tissue plasminogen activator-plasmin system.


Hiroyuki Mizoguchi, Kiyofumi Yamada, Akihiro Mouri, Minae Niwa, Tomoko Mizuno,Yukihiro Noda, Atsumi Nitta, Shigeyoshi Itohara,Yoshiko Banno andToshitaka Nabeshima.

Role of matrix metalloproteinase and tissue inhibitor of MMP in methamohetamine-induced behavioral sensitization and Reward: implications for dopamine reseptor down-regulation and dopamine release.



Mina Ito, Taku Nagai, Hiroyuki Mizoguchi, Kosuke Sato, Minoru Hayase, Noboru Otsuka, Ayumi Fukakusa, Nozomi Kumagai, Hyoung-Chun Kim, Toshitaka Nabeshima, Kazuhiro Takuma and Kiyofumi Yamada

Activation of postsynaptic dopamine D1 receptors promotes the release of tissue plasminogen activator in the nucleus accumbens via PKA signaling.

J Neurochem 有 103 2589- 2596

平成19年

Minae Niwa, Atsumi Nitta, Hiroyuki Mizoguchi, Yoshihisa Ito, Yukihiro Noda, Taku Nagai, Toshitaka Nabeshima.:

A novel molecule "shati" is involved in methamphetamine-induced hyperlocomotion, sensitization, and conditioned place preference.

J Neurosci 有 27 7604- 7615

平成19年

Yoshiki Yagita, Kazuo Kitagawa, Tsutomu Sasaki, Yasukazu Terasaki, Kenichi Todo, Emi Omura-Matsuoka, Kozo Kaibuchi, Masatsugu Hori

Rho-kinase activation in endothelial cells contributes to expansion of infarction after focal cerebral ischemia

J Neurosci Res 有 85 2460-2469 平成19年

Katsuo Amioka, Takafumi Kuzuya., Hideyuki Kushihara,Masayuki Ejiri,,Atsumi Nitta, and Toshitaka Nabeshima.

Carvedilol increases ciclosporin bioavailability by inhibiting P-glycoprotein-mediated transport.

J Pharm Pharmacol

有 59 1383-1387 平成19年

Yukio Ito, Kazuhiro Takuma, Hiroyuki Mizoguchi, Taku Nagai and Kiyofumi Yamada

A novel azaindolizinone derivative ZSET1446, spiro[imidazo[1,2-a]pyridine-3,2-indan]-2(3H)-one, improves methamphetamine-induced impairment of recognition memory in mice by activating extracellular signal-regulated kinase 1/2.


有 320 819-827 平成19年

Dayong Wang, Yukihiro Noda, Hiroko Tsunekawa, Yuan Zhou, Masayuki Miyazaki, Koji Senzaki, Atsumi Nitta, Toshitaka Nabeshima

Role of N-methyl-D-aspartate receptors in antidepressant-like effects of sigma 1 receptor agonist 1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl) piperazine dihydrochloride (SA-4503) in olfactory bulbectomized rats


有 322 1305- 1314

平成19年

Kenji Maeda, Haruhiko Sugino, Tsuyoshi Hirose, Hisashi Kitagawa, Taku Nagai, Hiroyuki Mizoguchi, Kazuhiro Takuma and Kiyofumi Yamada

Clozapine prevents a decrease in neurogenesis in mice repeatedly treated with phencyclidine.

J Pharmacol Sci

有 103 299-308 平成19年

Takahiro Matsuya, Kazuhiro Takuma, Kosuke Sato, Makoto Asai, Yoshihiro Murakami, Sosuke Miyoshi, Akihiro Noda, Taku Nagai, Hiroyuki Mizoguchi, Shintaro Nishimura and Kiyofumi Yamada

Synergistic effects of adenosine A2A antagonist and L-DOPA on rotational behaviors in 6-hydroxydopamine-induced hemi-parkinsonian mouse model.

J Pharmacol Sci

有 103 329-332 平成19年

Minae Niwa, Atsumi Nitta, Kiyofumi Yamada, Toshitaka Nabeshima.:

The roles of glial cell line-derived neurotrophic factor, Tumor Necrosis Factor-α, and an inducer of these factors in drug dependence.

J Pharmacol Sci

有 104 116-127 平成19年

Shin EJ, Jeong JH, Kim HJ, Jang CG, Kiyofumi Yamada, Toshitaka Nabeshima, Kim HC

Exposure to extremely low frequency magnetic fields enhances locomotor activity via activation of dopamine D1-like receptors in mice.

J Pharmacol Sci

有 105 367-371 平成19年

Taku Nagai, Kazuhiko Takuma, Hiroyuki Kamei, Ito Y, Nakamichi N, Daisuke Ibi, Nakanishi Y, Murai M,

Dopamine D1 receptors regulate protein synthesis-dependent long-term recognition memory via

Learn Mem 有 14 117-125 平成19年


Hiroyuki Mizoguchi, Toshitaka Nabeshima, Kiyofumi Yamada.

extracellular signal-regulated kinase 1/2 in the prefrontal cortex.

Akihiro Mouri, Yukihiro Noda, Akihiro Noda , Nakamura T, Tokura T, Yura Y, Atsumi Nitta, Hiroshi Furukawa ,Toshitaka Nabeshima.:

Involvement of a dysfunctional dopamine-D1/N-methyl-D-aspartate-NR1 and Ca2+/calmodulin-dependent protein kinase II pathway in the impairment of latent learning in a model of schizophrenia induced by phencyclidine.

Mol Pharmacol

有 71 1598-1609 平成19年

Hiroshi Qadota, Kristina B. Mercer, Rachel K. Miller, Kozo Kaibuchi, Guy M. Benian

Two LIM domain proteins and UNC-96 link UNC-97/PINCH to myosin thick filaments in Caenorhabditis elegans muscle

Mol Biol Cell 有 18 4317- 4326

平成19年

Duo Jin, Hong-Xiang Liu, Hirokazu Hirai, Takashi Torashima, Taku Nagai, Olga Lopatina, Natalia A. Shnayder, Kiyofumi Yamada, Mami Noda, Toshihiro Seike, Kyota Fujita, Shin Takasawa, Shigeru Yokoyama, Keita Koizumi, Yoshitake Shiraishi, Shigenori Tanaka, M

CD38 is critical for social behavior by regulating oxytocin secretion.

Nature 有 446 41-45 平成19年

Akihiro Mouri, Yukihiro Noda, Takaaki Enomoto, Toshitaka Nabeshima.:

Phencyclidine animal models of schizophrenia: approaches from abnormality of glutamatergic neurotransmission and neurodevelopment.

Neurochem Int 有 51 173-184 平成19年

Dayong Wang, Yukihiro Noda, Zhou Yuan , Atsumi Nitta, Hiroshi Furukawa , Toshitaka Nabeshima.:

Synergistic effect of galantamine with risperidone on impairment of social interaction in phencyclidine-treated mice as a schizophrenic animal model.

Neuropharmacology

有 52 1179-1187 平成19年

Dayong Wang, Yukihiro Noda, Yuan Zhou, Atsumi Nitta, Hiroshi Furukawa, Toshitaka Nabeshima

Synergistic effect of combined treatment with risperidone and galantamine on phencyclidine-induced impairment of latent visuospatial learning and memory: Role of nAChR activation-dependent increase of dopamine D1 receptor-mediated neurotransmission

Neuropharmacology

有 53 379-389 平成19年

Dayong Wang, Yukihiro Noda, Zhou Yuan , Akihiro Mouri, Hiroyuki Mizoguchi, Atsumi Nitta, Chen W, Toshitaka Nabeshima.:

The allosteric potentiation of nicotinic acetylcholine receptors by galantamine ameliorates the cognitive dysfunction in beta amyloid25-35 i.c.v.-injected mice: involvement of dopaminergic systems.


有 32 1261-1267 平成19年

Tetsuo Ohnishi, Kazuo Yamada, Hisako Ohba Yoshimi Iwayama, Tomoko Toyota, Eiji Hattori, Toshiya Inada, Hiroshi Tatsumi Masahiko Kunugi, , Norio Ozaki, Nakao,Iwata Kaoru Sakamoto, Yoshimi,Iijima, Yasuhide Iwata, Kenji,Tsuchiya

A Promoter Haplotype of the Inositol Monophosphatase 2 Gene (IMPA2) at 18p11.2 Confers a Possible Risk for Bipolar Disorder by Enhancing Transcription.


有 32 1727-1737 平成19年


Genichi Sugihara, Shinichiro Nanko, Noriko Osumi, Detera-Wadleigh Sevilla D, Kato Tdafumi, Takeo Yoshikawa Nobuhisa Maeno ,Nagahide Takahashi ,Shinichi Saito , Xiafoi Ji , Branko Aleksic,Ryoko Ishihara , Keizo Yoshida , Toshiya Inada , Tetuya Iidaka , Norio Ozaki

Association study between the transferrin gene and schizophrenia in the Japanese population.

Neuroreport 有 18 (5) 517-520 平成19年

Minori Koga, Hiroki Ishiguro, Yasue, Horiuchi Albalushi Talal, Toshiya Inada, Nakao Iwata, Norio Ozaki, Hiroshi Ujike, Tatsuyuki Muratake, Toshiyuki Someya, Tadao Arinami

Failure to confirm the association between the FEZ1 gene and schizophrenia in a Japanese population.

Neurosci Letｔ有 417(3) 326-329 平成19年

Hiroki Ishiguro, Minori Koga, Yasue Horiuchi, Toshiya Inada, Nakao Iwata, Norio,Ozaki Hiroshi Ujike, Tatsuyuki Muratake, Toshiyuki Someya, Tadao Arinami

PICK1 is not a susceptibility gene for schizophrenia in a Japanese population: Association study in a large case-control population.

Neurosci Res 有 58(2) 145-148 平成19年

Yijin Yan, Kiyofumi Yamada, Hiroyuki Mizoguchi, Yukihiro Noda, Taku Nagai, Atsumi Nitta, Toshitaka Nabeshima.:

Reinforcing effects of morphine are reduced in tissue plasminogen activator-knockout mice.


Kazuhiro Takuma, Ai Matsuo, Yukiko Himeno, Yuki Hoshina, Yuuki Ohno, Yoko Funatsu, Sawako Arai, Hiroyuki Kamei, Hiroyuki Mizoguchi, Taku Nagai, Koji Koike, Masaki Inoue, and Kiyofumi Yamada

17?-Estradiol attenuates hippocampal neuronal loss and cognitive dysfunction induced by chronic restraint stress in ovariectomized rats.


Kazuhiro Takuma, Yuki Hoshina, Sawako Arai, Yukiko Himeno, Ai Matsuo, Yoko Funatsu, Yuuko Kitahara, Daisuke Ibi, Minoru Hayase, Hiroyuki Kamei, Hiroyuki Mizoguchi, Taku Nagai, Koji Koike, Masaki Inoue and Kiyofumi Yamada

Ginkgo biloba extract EGb 761 attenuates hippocampal neuronal loss and cognitive dysfunction resulting from chronic restraint stress in ovariectomized rats.


Takayoshi Mamiya, Mitsuo Kiseb, Keiko Morikawa, Hiromichi Aoto, Makoto Ukai and Yukihiro Noda

Effects of pre-germinated brown rice on depression-like behavior in mice

Pharmacol Biochem Behav

有 86 62-67 平成19年

Hritcu L, Clicinschi M, Toshitaka Nabeshima.

Brain serotonin depletion impairs short-term memory, but not long-term memory in rats.

Physiol Behav 有 91 652-657 平成19年

Mikiya Otsuji, Shuji Ishihara, Carl Co, Kozo Kaibuchi, Atsushi Mochizuki, Shinya Kuroda

A mass conserved reaction-diffusion system captures properties of cell polarity

PLoS Comput Biol

有 3 1040-1054 平成19年

Masaki Mishima, Ryoko Maesaki, Miyuki Kasa, Takashi Watanabe, Masaki Fukata, Kozo Kaibuchi,Toshio Hakoshima

Structural basis for tubulin recognition by cytoplasmic linker protein 170 and its autoinhibition

Proc Natl Acad Sci USA

有 104 10346- 10351

平成19年

Nobuhisa Maeno ,Nagahide Takahashi , Shinichi Saito , Xiafoi Ji , Ryoko Ishihara, Nagisa Aoyama ,Branko Aleksic, Hideki Miura, Masashi Ikeda, Tatsuyo Suzuki , Tsuyoshi Kitajima , Yoshio Yamanouchi, Yoko Kinoshita , Nakao

Association of SOX10 with schizophrenia in the Japanese population.

Psychiatr Genet

有 17 (4) 227-231 平成19年


Iwata , Toshiya Inada , Norio OzakiTabuse Hideaki, Kalali Amir,Azuma Hideki, Ozaki Norio, Iwata Nakao, Naitoh Hiroshi, Higuchi T,eruhiko Kanba Shigenobu, Shioe Kunihiko, Akechi Tatsuo, Furukawa Toshiaki

The new GRID Hamilton Rating Scale for Depression demonstrates excellent inter-rater reliability for inexperienced and experienced raters before and after training.

Psychiat Res 有 153(1) 61-67 平成19年

Taku Nagai, Kazuhiro Takuma, Misato Dohniwa, Daisuke Ibi, Hiroyuki Mizoguchi, Hiroyuki Kamei, Toshitaka Nabeshima and Kiyofumi Yamada

Repeated methamphetamine treatment impairs spatial working memory in rats: reversal by clozapine but not haloperidol.

Psychopharmacology

有 194 21-32 平成19年

Masashi Ikeda, Norio Ozaki, Yoshio Yamanouchi, Tatsuyo Suzuki, Tsuyoshi Kitajima, Yoko Kinoshita, Toshiya Inada , Nakao Iwata

No association between the glutamate decarboxylase 67 gene (GAD1) and schizophrenia in the Japanese population.


Norton Norton, Williams Hywel, Dwyer Sarah, Carroll Liam, Peirce Tim, Moskvina Valentina, Segurado Ricardo, Nikolov Ivan, Williams Nigel M, Ikeda Masashi, Iwata Nakao, Owen Micael J, O'donovan Micael C

Association analysis of AKT1 and schizophrenia in a UK case control sample.


吉見陽、野田幸裕【統合失調症関連遺伝子その機

能と分子病態】 COMTとドパミン関

連

Schizophrenia Frontier

無 8 159-164 平成19年

飯高哲也特集：画像で心（こころ）を探る：感

情とストレスを画像で探る環境と健康無 20（4） 508-516 平成19年

高橋長秀、齋藤真一、尾崎紀夫統合失調症のゲノム研究実験医学無 25（13）

156-160 平成19年

齋藤真一、尾崎紀夫向精神薬の薬理遺伝学研究精神科無 11(4) 317-322 平成19年

鈴木道雄、高橋努、上原隆、周世い

く、川崎康弘、住吉太幹、倉知正佳、

尾崎紀夫

統合失調症におけるストレス脆弱

性の様態統合失調症における脳

形態の変化とストレス脆弱性

精神神経学無 109 765-770 平成19年

吉村武、有村奈利子、服部敦司、貝

淵弘三

リン酸化シグナルが制御する神経

細胞の極性形成メカニズム蛋白質核酸酵

素無 52 753-759 平成19年

原英夫、井上誠、足立香代、米満

吉和、長谷川護、鍋島俊隆、田平武粘膜免疫を用いたアルツハイマー

病のワクチン療法. 日本神経精神

薬理学雑誌有 27 53-56 平成19年

永井拓、田熊一敞、亀井浩行、溝口

博之、鍋島俊隆、山田清文

放射状迷路を用いたdelayed spatial win-shift課題による空間作業記憶

の評価.

日本薬理学雑

誌有 129 457-462 平成19年

天野睦紀、貝淵弘三 Rho-kinase/ROCK/ROK 日本薬理学雑

誌無 129 308-310 平成19年

永井拓依存性薬物による精神障害の発現

機序の解明に関する研究日本薬理学雑

誌有 129 354-359 平成19年

永井拓自閉性障害の分子遺伝学. 日本薬理学雑

誌有 129 471 平成19年

田熊一敞、永井拓、山田清文学習・記憶行動の評価法. 日本薬理学雑

誌有 130 112-116 平成19年

毛利彰宏、野田幸裕、鍋島俊隆モデル動物を用いた水探索試験に

おける潜在学習能の評価方法

日本薬理学雑

誌有 130 141-146 平成19年

永井拓、鍋島俊隆学習・記憶とエピジェネティクス. 日本薬理学雑

誌有 130 521 平成19年

飯高哲也情動とストレス脆弱性を探る脳画

像研究-：遺伝的多型性を含めて脳を読む無 14-26 平成19年

飯高哲也特集：精神疾患の脳画像解析学と分子

生物学の統合：うつ病とストレス脆弱性

の脳画像・遺伝的多型に関する研究

分子精神医学無 7 20-24 平成19年


田谷真一郎、黒田啓介、貝淵弘三

DISC1と統合失調症分子精神医学無 7 25-30 平成19年

毛利彰宏、野田幸裕、岩田修永、黄

樹明、中島龍一、末元隆寛、樋口真、

Staufenbiel Matthias、小久保秀子、山

口晴保、西道隆臣、鍋島俊隆

アミロイド代謝異常と認知機能障

害分子精神医学無 7 169-172 平成19年

木下葉子、池田匡志、北島剛司、山

之内芳雄、岸太郎、川島邦裕、大河

内智、尾崎紀夫、岩田仲生

話題になった遺伝子多型・ハプロタ

イプのその後 PPP3CC 分子精神医学無 7 276-279 平成19年

波多野正和、池田匡志、亀井浩行、

尾崎紀夫、岩田仲生

話題になった遺伝子多型・ハプロタ

イプのその後 AKT1と統合失調症


池田匡志、高橋長秀、尾崎紀夫、岩

田仲生

【統合失調症の分子精神医学】 NRG1と統合失調症


天野睦紀、貝淵弘三

Rho/Rho-キナーゼと血管収縮機構脈管学無 47 337-341 平成19年

尾崎紀夫、池田匡志、高橋長秀統合失調症の分子病態解明に向

けた研究の動向臨床精神医学無 36 (1) 25-31 平成19年

飯高哲也特集：扁桃体と精神医学：うつ病・

不安障害と扁桃体臨床精神医学無 36（7） 849-854 平成19年

尾崎紀夫統合失調症のゲノム研究現況と

今後の方向性臨床精神薬理無 10 2352-236

1 平成19年

「こころの発達とストレス」グループ

著者名論文標題雑誌名査読巻ページ発行年

浦田悠

人生の意味の心理学モデルの構

成―人生観への統合的アプローチ

にむけて

質的心理学

研究有 In press

塩崎万里, 榎本博明子どもの心の健康教育プログラム―ス

トレス・マネジメント教育の試み

名城大学総

合学術研究

所紀要

無 14 63-66 平成 21 年

榎本博明語りを素材に自己を捉える名城大学

人文紀要無 43 31-40 平成 20 年

榎本博明自己物語から自己の発達を捉える

ための枠組み人間学研究無 5 1-17 平成 19 年

塩崎万里, 榎本博明学校における健康教育―わが国の

学校教育現場の現状

名城大学

総合学術研

究論文集

無 5 55-63 平成 19 年

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