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Obesity,CardiacHealth, and
Bupropion/Naltrexone THE DREAM AND THEN !HTMARE
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Obesity
▪
One"third o# the $% population is obese▪ One"third o# the $%
population is o&er'ei(ht▪ Associated 'ith a plethora o# )edical
co)plications
▪ T*DM▪ C+D▪ HTN▪ Depression▪ CAD▪ %tro e▪ %o)e cancers
American Journal of Preventive Medicine
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Obesity
▪
Obesity"related )orbidity leads to increasedhospitali-ation and
(reater )ortality▪ %econd to s)o in( as the leadin( cause o#
pre&entable
death▪ Esti)ated )edical costs o# obesity . 011 billion per
annu)▪ 2e' dru(s a&ailable due to e3cacy and sa#ety
concerns
▪ 2en"phen
▪ 45i#estyle )odi6cation has lon( been considered a)ainstay o#
therapy #or obesity, but his inter&ention has
produced only )odest 'ei(ht loss and no reduction in)a7or
ad&erse cardio&ascular e&ents 8MACE9:; 8 JAM
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Obesity
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T'o Dru(s
▪
Bupropion 8B$
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Conclusion
▪
B$< @ NA5 co)bination treat)ent 'or ed in syner(y toreduce
#ood inta e▪ E=ect li ely due to increased
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Conclusions
▪
B$< @ NA5 coad)inistration leads to a
'ei(ht"reducin(anorectic e=ect▪ 5on(er ter) studies needed to sho'
di&er(ence
bet'een B$< @ NA5 and B$< @ <▪
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Conclusions
▪ t is not possible to assess nonin#eriority due to earlytrial
ter)ination
▪ 4Cardio&ascular sa#ety o# this treat)ent re)ainsuncertain
and 'ill re uire e&aluation in a ne'ade uately po'ered outco)e
trial:;
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My conclusion
▪
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