Nutritional Therapies for Mental Healthdrlesliekorn.com › wp-content › uploads › 2018 › 06 › 07... · bone or two if you have it) to the crock, add 2 cups of dry pinto beans

LeslieKorn,PhD,MPHLMHC,ACS,RPP,NTP,NCBTMB

CopyrightDr.LeslieKorn,2018

Nutritional Therapies for Mental Health

Copyright,LeslieE.Korn,2018


Principle

“Diet is essential but not sufficient”

— Leslie Korn


Ethics & Nutritional Supplementation

• Rememberourethicsmodulereyourroleinnutritionalsupplementations

• Dependsonthestatewhereyoupractice• Yourscopeofpractice

• Identifyingyourroleasprimaryorreferring&collaborative

• Rememberyoumaybetheonlyclinicianinyourclientsteamwhonowsabouttherangeofoptions


• AddressCauseofdis-ease/imbalances

• Reduceinflammation&oxidativestress

•Managestressresponse

• Enhancemitochondrialfunction

• BalanceCircadianrhythm

• Enhanceneuronalcommunication

• AddressEpigenetics:Howfoods&nutrientscanaltergeneexpression

Goals of Nutritional Therapy


Goals of Nutritional Therapy

• IdentifyBiochemicalindividualneeds

• Enhancedigestion&utilizationofnutrients• Delivereasilyassimilatedhighdosenutrients

• Manage/reduce/eliminatesymptoms

• Alternatives/synergiststopharmaceuticals

• Identifyadherencestrategiesincludingdose&delivery

Copyright,LeslieE.Korn,2018 7

The Essentials of Nutritional Supplement Dosing

• Treattheindividual,notthedisease/symptom

• Spreaddesiredeffectsacross4broadareas:

• Vitamins,Minerals,AminoAcids&Glandulars

• Tailorprotocoltoclientneeds&planforincrementalchange

• Startlowerdoses&increaseslowly

• Adjustchildren’sdoses:age&bodyweight

• Corefoundationfirst:

• BroadspectrumVitamins,Minerals,Fats,AminoAcids,Glandular

• Additional,higherdosesofspecificnutrientsasneeded


The Essentials of Supplement Dosing

•Assessmentbaseddeliverysystemforclient

•Highquality,naturalformsupplements:lookforfoodsourcesofvitaminsonlabelor100%natural

•Usesupplementscofactors

•Readlabels:lowerqualityvitamins(additives,fillers&foodcoloring)

• Searchforafewsupplementscombinevarietytoprovidemostofwhatyouneed


•Balanceuseofvitamins,minerals,fats,botanicals&glandulars

•Review&adjusttheprotocolevery3-6months

•Startslowly&buildaccordingtoadherence

•Startwithwhereyouwillobservefastest&mostimportantchangesfirst;eg.anxiolytic/antidepressantetc.

Dosing: Vitamins, Minerals, Botanicals & Glandulars


Contraindications & Side Effects

Nutrients may • Slow/increasemetabolism/excretionofcertainmedications

• Potentiate/synergizeactionofcertainmedications

• Exacerbateexistinghealthconditions/contraindicated


• 5-HTP,Melatonin

• Kava,St.JohnsWort

• Mixingofnutrients,drugs&herbs

• Nutrientdeficitsasaresultofmedications

• Comprehensivedrug-nutrient-herbanalysis

Keeping Your Clients Safe with Supplements & Herbs

http://www.integrativepro.com/Resources/Drug-Nutrient-Interaction-Checker


•Whattolookfor?

• Resources

• Herb,Nutrient,&DrugInteractions:ClinicalImplications&TherapeuticStrategies,MitchellStargrove

• Herb,Nutrient,&DrugInteractions:ClinicalImplications&TherapeuticStrategies,Stargrove

• PDR

• Onlinedatabases

Drug, Nutrient & Herb Interactions

Best Vitamins, Minerals, Amino Acids,Fats, Glandulars, & Special Nutrients for Mental Health


• B-Vitamins&Minerals

• FreeAminoAcids

• Fats(dietary&supplemental)

•Probiotics

•Glandulars

Core Nutrients for Mental Health


• Simpletointegratefood&nutrientsforadults&children

• Usepowderednutrients

• AddFish&Borage/CoconutOils

• Probioticspowder

• Protein(whey,pea,hempprotein)

• Berries,Chocolate,Stevia

How to Take Nutrients? Smoothies


Essential Vitamins for Mental Health

Vitamins •Water-soluble:

• Dissolvedinwater&arenotstoredinthebody

• Riskofoverdosingisverylow

• Fat-soluble:

• Absorbedbyfat

• Requiresufficientdietaryfatstobestoredinbodytissues


• AskforyearlyserumVitaminDtesting

• VitaminDdeficiencyassociatedwithdepression&pain,immuneproblems

• High%ofdeficiencyinUSpopulation

• Oraldoseof50,000IUofvitaminDonceaweekfor8weeks*

• Long-termprevention=50,000IUofvitaminDonceortwiceamonth.*

*Holick,Michael.DepartmentofMedicine.DivisionofEndocrinology,Diabetes,andNutrition. BostonUniversitySchoolofMedicine,Boston,MA.

First Steps: Vitamin D Deficiency


Water-soluble: Complex B Vitamin

• StartwithB-complex

• Supportrelaxation,cognition,&neurologicalhealth➔cofactorsinneurotransmitters


• ComplexBVitaminsare1stchoicecoresupportforbrainneurologicalfunctionEg.B-6supportsNTfunction;supportsbloodglucose

• MTHFR(Methylenetetrahydrofolatereductase)isanenzymethatisneededtoconvertfolate

• GeneticMTHFRvariation:unabletoconvertisestat40%

• ConvertshomocysteinetomethionineessentialforNTdevelopment

• Implications?depression,bipolardisorder,schizophrenia,attention-deficithyperactivitydisorder(ADHD),orautism

• Individualswiththisgeneticvariation(snp)take:

• L-Methylfolate(5-MTHF):thebiologicallyactiveformofvitaminB9

B-Vitamins, 5-MTHF & Genetics


Water-Soluble: Vitamin B3

• Niacin&niacinamide:fordepression,anxiety,&alcoholaddiction

• Niacincauses(unpleasant)flushing

• Niacinamide➔GABAreceptors

• Usedformoodstabilization&asasedative

• Staplefortreatmentofanxiety,depression,insomnia,dementia&alcoholwithdrawal(Prousky,2005)

• Largedosesofniacin&niacinamideforschizophrenia(Hoffer,1962)

• 15gramofL-methylfolate(or500mgofthiaminet.i.d.)to3-8gramsofNiacinamide,toimproveoutcomesalongsidetheuseconventionalantipsychotics(Lake,2006)



• Picamilon(nicotinyl-y-aminobutyricacid):niacin&GABAcompound

• Crosstheblood-brainbarrier

• Increasebloodflowinbrain

• Usedfordepression,alcoholism,migraines,&TBI

Contraindications • Niacinabove3,000mg.aday:monitorresponsewithhealthprofessional

• Possiblenausea&vomitingathighdoses



•B6deficiency➔insomnia,hypertension,PMS,&irritability

•Commonlyusedfordepression&anxiety

•SSRIformulationsoftencontainaddedB-6

•Pyridoxal5’-phosphate(P5P):preferredform

•ActivecoenzymeformofvitaminB6



• Inositoleffectivefordepression,panicattacks,agoraphobia,obsessivecompulsivedisorder,bulimianervosa,&bingeeating

(Gelber,Levine,Belmaker,2001)

• ReducesOCDsymptoms• (Levine,1997)

• MoreeffectivethanfluvoxamineinthereductionofOCDsymptoms(Gelberetal.2001)

Contraindications • Highdosescancauseupsetstomach



• Folate,naturalform:Invarietyofplant&animalfoods

• Folicacid,syntheticform:Usedinsupplements&fortifiedfoods

• Strongcorrelationbetweenadeficiencyinfolate&depression

• High%ofpopulationdeficientinenzymerequiredtoconvertfolicacid➡activeform5-methyltetrahydrofolate(5-MTHF).Deficitmanifestsinhighhomocysteinelevels

• BioactiveL-5-MTHF

• Avoidfolicacid



Contraindications •L-methylfolate,fewtonosideeffects

• Ifsystemicinflammationishigh:experienceirritability,&insomnia

• Startatlowdose,alwaysincludesupplementalmethylB-12,&niacin



•B12isanessentialvitamin

•Usedtotreatwithdepression,fatigue,anxiety,&psychosis

•Co-factorinmethylationprocessleadingtoSAMe

•Anxiolytic(Prousky,2005)

•MetformindepletesthebodyofB12


Water-Soluble: Choline

•Naturallyincellmembranelipidsinbrain

• Synthesisofacetylcholine:memory&learning

• 3commonlyusedformsformentalhealth:

• CDP-Choline(cytidine-5’-diphosphatecholine)A.K.A.citicoline

• Breaksdowninto:

• Phosphtyidalcholine

• Breaksdowninto:

• Alpha-GPC


Water-Soluble Choline

• CDP-cholineacceleratedrecoveryinheadtraumapatients(Secades&Frontera,1995)

• 500mgCDP-cholinetwicedailymayhelpreducecravingsforcocaine

(Renshaw,Daniels,Lundahl,Rogers,&Lukas,1999)

• Combinedwithlithium(carbonate)reducesmanicsymptomsinbipolardisorder

(Lyoo,Demopulos,Hirashima,Ahn,&Renshaw,2003)


Water-Soluble: Vitamin C

•QualityvitaminCisaComplex(notjustascorbicacid)

•Containsbioflavonoids&rutin

•Eatingcitrusfruits’pulpprovidesbioflavonoids


Fat Soluble Vitamins

•A•D• E•K•Needfattoabsorbtheseessentialvitamins

•Besttakenwithahigherfatmeal

• Lowfatdietsatriskfordeficiency


Fat-Soluble: Vitamin A

•Agroupofcompoundscalledretinoids

•Eyes

•Immunesupport

•Skin/lungs


Fat-Soluble: Vitamin D

•Prevention&treatmentofdepression&chronicpain

•VitaminDreceptorsinbrain⬆serotoninproduction(Holick,2003)

•Neurohormonehelpsbodyabsorbcalcium,magnesium,phosphate,iron,&zinc

•CholesterolisaprecursortovitaminD(Vasquez,Manso,&Cannell,2004)

• Dosing:5000iu+/-day:Annualtest:levels50-80/ng/mL• Emulsifieddrops


Fat-Soluble: Vitamin E

•Comprisedof8fat-solubleantioxidantcompounds(tocopherols&tocotrienols)

•⬆vitaminEassociated⬇riskofcognitivedecline&

Alzheimer’sdisease(Mangialascheet.al.,2012,2013)

• 400IUdailymixedtocopherols&tocotrienols


Fat-Soluble: Vitamin K

• 2majorformsofVitamin:Bones&Heart

• K1(phylloquinone):Higherlevelsassociatedwithbettercognitivefunction

inelders(Presseetal.,2013)

• K2(menaquinone):essentialfornervehealthinthebrain

• SupplementationshouldincludeK1&2

VitaminK1&dualformsofK2,MK-4&MK-7

100mcgofvitaminK2(MK-7);1,000mcgofvitaminK2(MK-4);and1,500mcgofvitaminK1

Contraindications • Peopletakinganticoagulants(bloodthinners)


Essential Minerals for Mental Health

• “Sparkplugs”(Watts,2006)

•Macrominerals:

• Bodyneedstheminlargeramounts

• Theseincludecalcium,phosphorus,magnesium,sodium,potassium,chloride&sulfur

• Traceminerals:

• Smallamounts

• Iron,manganese,copper,iodine,zinc,cobalt,fluoride&selenium


Minerals: Chromium

•Usedfordepression&moodregulation

•Associatedwithhypoglycemia&iseffectiveindecreasingcarbohydratecravings&bingeeating(Brownley,VonHolle,Hamer,LaVia,&Bulik,2013)

• Chromiumpicolinate500-1000mcg


Minerals: Calcium

•Overuseofcalciumsupplementsbypost-menopausalwomen➡fatigue,exhaustion,headaches,depression,anxiety&insomnia

(Watts,2006)

•Overconsumptionmayinhibitzinc,phosphorous,&copperabsorption


Calcium Rich Soup

Add8cupsofbonebroth(andamarrowboneortwoifyouhaveit)tothecrock,add2cupsofdrypintobeans&thenadd3tablespoonsofblackstrapmolasses,aheadofchoppedbroccoliincludingstems,4potatoes(cubed)abunchofchoppedkaleandapinchofyourfavoriteseaweed.

Cookonlowfor8hours&addapinchofseasalt,blackpepperbeforeserving.Youcantopitwithwalnuts.


Minerals: Lithium

• Firstmineralsupplementformooddisorders(Schrauzer&deVroey,1994)

• LengthensCircadianRhythm

•Neuroprotective&anti-inflammatory,increaseshippocampalvolume,increasesbrainderivedneurotrophicfactor(BDNF)

• ReducesriskofdevelopmentofAlzheimer’sinbipolarpatientswhotakeitregularly

(Diniz,Machado-Vieira,&Forlenza,2013)

• LithiumOrotate20-50mg


Minerals: Lithium

• PeoplewithBiPolar,depression,cognitivedecline&memoryloss(Forlenzaetal.,2011);(Nunes,Viel,&Buck,2013)

• Alcoholrecovery&relapseprevention(Sartori,1986)

• Lithiumorotatecrossesblood-brainbarrier,

• Carbonateformdoesnot

Contraindications • Nottobetakenbypregnant&lactatingwomen


Minerals: Magnesium

•Anxiolytic,antistressmineral

•Supportshealthycognitivefunction&mood

•Deficiencyiscommon

•Improvesserotoninsynthesis&reducesinflammation, &oxidativestress

•Aspartate:aseffectiveaslithiumin50%ofseverelyillrapid-cyclingbipolarpatients

(Chouinard,Beauclair,Geiser,&Etienne,1990)


Minerals: Magnesium

•Mostabsorbableformsofmagnesium:glycinate&L-threonate,anewformdevelopedtocrossthebloodbrainbarriers.Improvesshort-termmemory

(Abumariaetal.,2011)

• Increasesoverallcognitivefunction(Slutskyetal.,2010)

• ResearchsuggestsL-threonateactsasantidepressant&candampentraumaticmemories

(Abumaria,Yin,Zhang,Zhao,&Liu,2009)


Magnesium Threonate

•Significantlyincreaseslevelsofmagnesiumwithinbrain

•Maintainsthequantityofsynapticconnectionsbetweenbraincells

• Improvedshort&longtermmemory(SlutskyI,AbumariaN,WuLJ,HuangC,ZhangL,LiB,ZhaoX,GovindarajanA,ZhaoMG,ZhuoM,TonegawaS,LiuG.2010)

(LiW,YuJ,LiuY,HuangX,AbumariaN,ZhuY,HuangX,XiongW,RenC,LiuXG,ChuiD,LiuG1.2014)

43


Minerals: Potassium

•Deficiency➡Bulimia&anorexia

(Higdon,2004)

•Potassiumorotate&citrateveryeasilyabsorbed


Minerals: Selenium

• Elevatesmood,reducesinflammation,enhancesimmunity

Contraindications • Veryhighdosesofseleniumcanbetoxic


Minerals: Zinc

•Antidepressant(Levenson,2006)

•Cognitivefunctioninelderadults

(Mayloretal.,2006)

• Supplementinbulimia&purging,anorexiadisorder


Minerals Copper

•Regulatescellularenergyproduction&neurotransmission

•BothHigh&Lowcopperlevelslinkedtodepression

•Source:wellwater

•Antacidsinterferewiththeabsorptionofcopper


Minerals: Iodine

•Foodsourcesofiodine:seafood,seaweed&iodizedsalt

•Supplementationcanbenefitfatigue,ADHD&ASD


Minerals: Iron

• Irondeficiency⬆riskofmooddisorders,autismspectrum

disorder,attentiondeficit,hyperactivitydisorder(Chenetal.,2013)

• Irondeficiency⬆Fatigue,anemia,poorcognitivefunction&

developmentaldisorders

• VitaminCimprovesironabsorption


Antioxidants

Body’ssystemofprotection➔neutralizefreeradicals

Excessoxidation➔toomanyfreeradicalsforantioxidantstoneutralizethem➔“oxidativestress”

⬆Celldestruction

N-acetylcysteine. boost production of glutathioneAlpha lipoic acid. Coenzyme Q10 (CoQ10)Milk thistle


Probiotics

•Arandomizedcontrolledtrialtotesttheeffectofmultispeciesprobioticsoncognitivereactivitytosadmood

•Intakeofprobioticsmayreducenegativethoughtsassociatedwithsadmood

(Steenbergen,Sellaro,vanHemert,Bosch,Colzato,2015)


Essential Fatty Acids

•DHA,aconstituentoffishoil

•⬆communicationbetweensynapses,⬆dendriticspineson

postsynapticneurons

• Higherbloodlevelsoffishoil=withincreasedbrainvolume(Pottalaetal.,2014)

TheFishOilYouthDepressionPilotStudy.Arandomised,doubleblind,placebo-controlledtreatmenttrial(1.4gms

Upto20gm.dailyoffishoilforthetreatmentoftraumaticbraininjury(Lewis,Ghassemi,&Hibbeln,2013)


Fats, Mood & Cognition

GLA- rich plant oils

● Borageseed● Eveningprimroseseeds● Blackcurrantseed

● Hemp

and● MoodBoosters:citrussmells—Grabanorangeorlimerightnow


Medium Chain Fatty Acids & Cognition

• Increasesketonebodies:improvescognition&memory

•SignificantresearchforMCT&cognitiverepair

•Promotes&nourishesneuronalcommunicationbyincreasinggrowthofdendrites(nerveendings)

•Coconut,Palm,(lesseringrassfedbutter)

•AddrawButter&coconutfattocoffee


•Aminoacidsareprecursorstoneurotransmitters

•Productionofneurotransmittersisaffectedbyaminoacidsindiet

•Poordiet/lowproteindecreasesneurotransmitters

•PoorFatsdecreaseneuronalcommunication

•EFA’saresynaptic“lube”

Amino Acid Therapy


Amino Acids

•Aminoacidtherapies=alternativetopsychotropicpharmaceuticalmedications

• Freeaminoacids

Contraindications • Peoplewithtardivedyskinesiashouldnottakephenylalaninesupplements


• FreeAminoAcids

• B-ComplexwithB-6&B-12

• Magnesium

• Theanine

• CurcuminwithBlackPepper

• Tyrosine(rhodiola)

• Eggs,Eggs&moreEggs

-Acetylcholine

Top 7 nutrients essential for Neurotransmitter Balance


NT’S AMINO ACIDS/ NUTRIENTS BOTANICALS FOODS ENTHEOGENS

GABAGlutamine,taurine, milkderivedneuropeptides.Lithiumorotate,

phenibut

Valerian,hops,skullcap,

greentea,kava

Walnuts,oats,

spinach,beansliver,

mackerel

SerotoninTryptophan, 5HTP,B-vitamins,espB-12,B-6,niacicinimide,folicacid

St.John’swort

Salmon,beef,lamb,

figsbananas,root

vegetables,brownrice

LSD,Psilocybin,DMT,

Ibogaine,Ayahuasca

Dopamine Tyrosine,DL- Phenylalanine,B-12,B-6 Ginseng,Fenugreek

Coffee,tea,eggs,

pork,darkchocolate,

ricottacheese

MDMA/MDE

Mescaline

Norepinephrine Tyrosine StJohn’swort,Holy

basil,licoriceMeats,fishescheese

MDMA/MDE

Mescaline

AcetylcholineGPCcholine, phosphatidylserine, acetyl-L-carnitine, huperzine

Sage,Bacopa,Melissa,

Ginkgo,Ashwaganda

Eggs,liver,salmon

shrimp,nutbutters,

coffee

Scopolamine

(contraindicated)

Glutamate GlutamicAcid GotuKola,Kava,

Passionflower

Caffeine,fermented

foods,chicken,eggs,

dairy

Ketamine

Ibogaine

Endogenousopioids

Milkbiopeptides Papaversomniferum

Casein(milk),gluten

(grains),spinach,fat,

fasting

Ibogaine,

Salviadivinorum

Cannabinoids Fishoil,lactobacilli Cannabis Hempseeds/hempoil Cannabis


Neurotransmitters & Precursors


GABA

Glutamine, taurine milk derived

neuropeptides. lithium orotate,

phenibut

Valerian, hops, skullcap, green tea,

kava

Walnuts, oats, spinach, beans liver, mackerel


Copyright,LeslieE.Korn,2018Copyright,LeslieE.Korn,2018

NT’SAMINO ACIDS/

NUTRIENTS BOTANICALS FOODS ENTHEOGENS

SEROTONIN

Tryptophan, 5 HTP, B-

vitamins, esp B-12, B-6,

niacicinimide, folic acid

St. John’s wort

Salmon, beef, lamb, figs

bananas, root vegetables, brown rice

LSD, Psilocybin, DMT, Ibogaine,

Ayahuasca



Copyright,LeslieE.Korn,2018Copyright,LeslieE.Korn,2018


ENDOGENOUSOPIOIDS Milk Biopeptides Papaver

somniferum

Casein (milk), gluten (grains),

spinach, fat, fasting

Ibogaine, Salvia divinorum




Theanine

•Aminoacidfoundingreen&blackteas

•Crossestheblood–brainbarrierwhereitactsasananxiolytic


Coenzyme Q10

• Vitaminlike,fat-solublesubstancefoundinmitochondria

• Twoforms:ubiquinol&ubiquinone,equallyeffective

• Beneficialfortreatmentofbipolar,depression,fatigue,fibromyalgia&schizophrenia

Contraindications • Canreducethebody’sresponsetobloodthinning(anticoagulant)medicine

• Candecreaseinsulinrequirementsinpeoplewithdiabetes


Garum Armoricum: Stabilium

• Fishbioactivepeptidesusedforhealth

• DerivedfromextractofBlueLingFish(Molvadypterygia)

• FoundoffthecoastoftheArmoricanPeninsulaofFrance

• Richinaminoacids&neurotransmitterpeptides,fattyacids,&vitaminE(Dormanetal.,1995)

• Reducesstress&anxiety

• Improvesmood&sleep

• StabiliumisalternativetolactiumwhencaseinsensitivityTheEffectivenessofGarumArmoricum(Stabilium)inReducingAnxietyinCollegeStudentsDormanT,etal.

JournalofAdvancementinMedicine,Vol.8(3):193-200,1995


Lactium

•DevelopedinFrance,genericnameofbioactivemilk-derivedpeptides

•ActsonGABAreceptors

•Reducesstress&cortisollevelswhileinducingrelaxation&improvingmentalfunction

• Improvesleep

(Clare&Swaisgood,2000);(Delini-Stula&Holsboer-Trachsler,2009);(deSaint-Hilaire,Messaoudi,Desor,&Kobayashi,2009)


Melatonin

• Hormonesynthesizedasthefinalmetabolitebythetryptophan-serotoninpathway.

• Theuseoftryptophanor5-HTPmayeliminatetheneedformelatonin

Contraindications • Alpha-andbeta-blockingdrugsusedforhypertensioncandisruptsleepby⬇melatoninrelease

(Stoschitzkyetal.,1999)


Phosphatidylserine

• Phospholipid:keycomponentofcellmembrane

• Essentialfortransferofbiochemicalmessagesintocellswithinbrain&centralnervoussystem

• RegulatescortisollevelsviatheHPA-axis

•⬆acetylcholineinbrain

• Supportsmemoryinchronicstress,depression,ADHD,PTSD&TBI

• Eggyolks&liverrichPSsources


Phenibut

• DerivativeofGABA:actsonbothGABA&dopaminereceptors

• Alternativetobenzodiazepines

• Usefulforshort-termtreatmentofanxiety;drug&alcoholwithdrawal

Contraindications • Caution:candevelopdependence

• ConsultwiththeirprescriberbeforeifusingMAOinhibitors/epilepsymedications(carbamazepine/oxcarbazepine)


Bromelain

• Inhibitscyclooxygenaseenzyme

• Inhibitssynthesisofprostaglandin2

• Breaksdownfibrin&reducesswelling

• Formfoundationofanti-inflammatorytreatment

• Usedforpain&fibromyalgia(withcoq10)


RNA/DNA Supplements

• Recoveryfromillness&surgery

• Cognitivefunction• Immunesupport

• Diet:• Proteins,synthesisfromaminoacids&glucose

• Supplements

• Four“ribonucleotides”CytidineMonophosphate(CMP),UridineMonophosphate(UMP),AdenosineMonophosphate(AMP),&GuanosineMonophosphate(GMP)

• Enhancebrainphospholipids&learning• Cognitex(w/w/oPregnenalone)


•Traditionalfoodsglands&organs

•Lyophilized/dehydratedglands

•Target&rebuildtissues

Glandulars


Glandulars-Foods & Supplements

• Brain

• Hypothalamus

• Pituitary

• Adrenal

• Thymus

• Liver

• Heart

• Thyroid

• Lung

TraditionalFoods• Tripe

• Lung/Chanfaina

• Sweetbreads

• Heart

• Liver

• Tongue

• Testicles

• Kidneys

• Blood

GLANDULAR BENEFIT DOSERANGE

Adrenal

HelpsthebodyrespondtostressSupportsimmunefunctionSupportsmetabolismandphysiologicalfunctionofadrenalglands

Addressesfatigue,sugarmetabolism,andweightloss

100mgb.i.d.aor200mgt.i.d.a

AdrenalCortexHelpstosupportahealthystressresponse

250mg(1,t.i.d.)

Brain SupportsHPAaxis,depression 250mg(1-2,t.i.d.)

Glandular Supplementation - Part 1


Hypothalamus SupportsHPAaxis,depression,TreatmentofTBI 500mg(1-3,t.i.d.)

Liver Supportsliverinalcoholanddrugrecovery,detoxification,chemicalsensitivity

400mg(1-2,t.i.d.)

Pancreas

Supportdigestion Maysupport&modulatetheimmunefunction Maysupportbloodglucosewithinnormallimits Supportspancreaticfunction&fatdigestion

400mg(1-2,t.i.d.)

Pituitary SupportHPAaxisdepression 250mg(1,b.i.d.)



Thymus Immunefunction 1,000mg(1-2,t.i.d.)

Thyroid Lowthyroidfunction 40mg(1-2,3x/day)



• Educateyourclient:roleofnutritionalsupplementationinwell-being

• Prioritizecorenutrientsforclient;whatwillcomefromsupplements/foods(e.g.probioticssupplementsorfreshfermentedfoodsorboth)

• Reviewassessmentfindings&matchspecificmodesofingestion(e.g.smoothies,capsules,andliquids,IVetc.)

• Applydrug/nutrientinteractionsdatabaseasconsiderprotocoldesign

• Considerifaconsultationwithaprescribingclinicianisnecessary

• DevelopCore&Adjunctnutrientprotocol

• Identifyobstacles/challengestoadherence

Steps for Nutritional Protocols


Myer’s Cocktail

• Magnesium

• Calcium

• VitaminsB12,B6,&C

• Effectiveagainst:

• Migraines

• Fatigue(chronicfatiguesyndrome)

• Fibromyalgia

• Acutemusclespasm(Gaby,2002);(Massey,2007)


Chronic Pain Treatments

• ChronicPainiscomorbidwithdepression,similarapproachtotreatment

• 5-hydroxytryptophan• D,L-phenylalanine• Foracutepain,useitat250mgeverytwohours

• Forchronicpainordepression,use500mgthreetimesaday

• Fishoils

• Capsaicin(topical)

• CompoundedKetoprofen,KetamineCapasaicin

• CBD-richtincture

• CranialElectircalStim

Depression - Part 1NUTRIENTS DOSE

ComplexvitaminsandmineralswithL-methylfolate Dosevariest.i.d.

Omega-3fishoil 1–3gramso.d.

Gammalinoleicacid(GLA)/borageoreveningprimroseoil 1,000mgo.d.

Freeaminoacids Dosevariesb.i.d.

Probiotics 100+billionCFUso.d.

VitaminD50,000IU(oral,1x/weekfor8weeks)fordeficiency 2,000–4,000IUo.d.formaintenance


GlucoseTolerancefactor 1-2capsulest.i.d.

VitaminB6 10mgq.i.d.

Niacinamide Niacinamide

Methylcobalamin 1-2mcgo.d.

LithiumOrotate 50-150mgo.d.

Magnesium 400mg


5-HTP 50-100mgo.d.

Or/Tryptophan 50-100mg

L-Tyrosine 250-500mgb.i.d.

AdrenalGlandular 100-200mgt.i.d.

HypothalamusGlandular 500-1500mgb.i.d.

Melatonin 0.5-1mgo.d.

Lactium

OrthophosphoricAcid 30dropso.d.

Seasonal Affective Disorder - Part 1NUTRIENTS DOSE







Seasonal Affective Disorder - Part 2NUTRIENTS DOSE

GlucoseToleranceFactor 1-2capsulest.i.d.

VitamB6 50-100mg.o.d.

Tryptophan 500mg.o.d.@night

Melatonin 0.5-1mgo.d.night

SAMe 400-600mgo.d.

Wheyprotein 2heapingtablespoonso.d.

Alcohol - Part 1NUTRIENTS DOSE


High-dosePhosphorylatedThiamineB-VitaminMineralComplex 1-2mcgo.d.

Omega-3FishOil(DHA/EPA) 1-2gmt.i.d

GammaLinoleicAcid(GLA)/BorageorEveningPrimroseOil 1000mgo.d.

FreeAminoAcids Dosevariesb.i.d.



VitaminD50,000IUor/

2000-5000IUo.d.

GlucoseToleranceFactor 1-2capsulest.i.d.

CDP-Choline 500mgb.i.d.

LiverGlandular 400mgt.i.d.

AdrenalGlandular 200mgt.i.d.

HypothalamusGlandular 500mgt.i.d.


Niacinamide 500mg

Magnesium 1-2capsulest.i.d.

Potassium 500mgb.i.d.

Lithiumorotate 400mgt.i.d.

5-HTP 200mgt.i.d.

Tryptophan 500mgt.i.d.

Melatonin 0.5–1mg


Phenibut

(w/Anxiety)250-500mgo.d.

Phosphatidylcholine 800-1200mgb.i.d

SAMe 400mgb.i.d.

Lactium

(w/Anxiety)150-300mgo.d.

Anxiety - Part 1NUTRIENTS DOSE








B6pyridoxalphosphate 50mgb.i.d.

B-12methylcobalamin 1,000mcgo.d.

Niacinamide 500mgb.i.d.

MagnesiumL-threonateorglycinate 100–400mg

AlphaGP-choline 600–1,000gramso.d.

Tryptophan 500mg


Lactium 150–450mgasneeded450–600mgforsleep

Orthophosphoricacid 30dropso.d.

Lithiumorotate(Depressionandmoodlability) 45mgo.d.(Shealy,2006)

Taurine(Highbloodpressureorgallbladderissues) 500–1,000mgt.i.d.

Glycinestrips(Acutepanic)2g(sublingually)everyfewminutes(Prousky,2005)

Phenibut 250–500mgo.d.


Adrenalglandularstress 100mgb.i.d.or200mgt.i.d.

Stabilium(Garumarmoricum)(Useifcaseinallergy) 200–400mgo.d.

Oralmicronizedprogesterone(Prescriptiononlyformenopausalwomen) 50–100mgo.d.

Phosphatidylserine(Posttraumaticstressdisorder) 100mgt.i.d.

Sleep/Wake Disorders - Part 1NUTRIENTS DOSE

Complexvitamins&mineralswithL-methylfolate Dosevariest.i.d.







Glucosetolerancefactor 1–2capsulest.i.d.

B-12methylcobalamin 1mgo.d.

Magnesiumthreonate 100–400mgo.d.

LithiumOrotate 1.5mgo.d.

Alpha-lipoicacid 200mgo.d.

Melatonin 0.5–1mgnight


Lactium 450–600mgo.d.

5-HTP(optional) 25–100mgo.d.

Phenibut(optional)250–500mgo.d.(reduceafter1monthtoeveryotherday)

NUTRIENTS DOSE







Protocol for Psychosis/Schizophrenia - Part 1

Protocol for Psychosis/Schizophrenia - Part 2NUTRIENTS DOSE


Glycine 4–8gramsb.i.d.

Glutamine 5gramso.d.

N-acetylcysteine(NAC) 300–600mgb.i.d.

Pregnenolone 50mgb.i.d.

Glutamine(optional) 500–5,000mgo.d.

Protocol for Psychosis/Schizophrenia - Part 3NUTRIENTS DOSE

CBD-richcannabis(optional) p.r.n

Proteolyticenzymes(optional) 500–1,000mgevery4–6hr(awayfromfood)

Obsessive-Compulsive Disorder - Part 1NUTRIENTS DOSE

Complexvitamins&mineralswithL-methylfolate Dosevariest.i.d.








VitaminB-12Injectionsuntilbloodlevelreaches900g/mL;thereaftersublinguallevelsofB-12:1mg

L-theanine/lactium 100–400mgo.d.

Melatonin 0.5mgatnight

N-acetylcysteine 1,200–2,400mgo.d.

Glycine 1–3gramst.i.d.


5-HTP 25–100mgb.i.d.

L-tryptophan 500mgatnight

Inositol 1,000–3,000mgt.i.d.


1. VitaminCtosaturation(ontheorderof10,000to20,000mgperday&more) Totitratetosaturation,take1000mgofvitaminCeveryhour.Whensaturationisreached,therewillbeasingleepisodeofdiarrhea;thenreducethedosageto1000mgeveryfourhours

2. L-Glutamine(2000or3000mg).Decreasesphysiologicalcravingsforalcohol.L-Glutamineisnaturallyproducedintheliver&kidneys

3. Lecithin(2to4tablespoonsdaily).Providesinositol&choline,relatedtotheB-complex.Lecithinalsohelpsmobilizefatsoutoftheliver

Dr. Hoffer’s Protocol for Alcohol Recovery


4. Chromium(atleast200toperhaps400mcgchromiumpolynicotinatedaily).Chromiumgreatlyreducescarbohydratemis-metabolism,&greatlyhelpscontrolbloodsugarlevels.Many,ifnotmost,alcoholicsarehypoglycemic

5. Magnesium(400mg)&theantioxidantscarotene&d-alphatocopherol

Dr. Hoffer’s Protocol for Alcohol Recovery


Definition: Cognitive Impairment

• Troubleremembering,learningnewthings,remembering,concentrating/makingdecisions

• Rangesfrommildtosevere

• Beginsbeforesymptomsappear:Trans-Fats=riskfactor

• Intensivenutrientsupportdiet&exercisecanreversedecline&slowitinlaterstages

• Lotsof(mis)diagnosesrelatedtomood&cognition

• Severaltypesofdecline:includingEvidencefornoninflammatory-lowzinctypeAD


Alzheimers: Diabetes Type 3

• “Whatoccursintheheartoccursinthebrain”• Target:• Inflammation(turmeric;hops&rosemarysuppressinflammatorycytokines)

• Blood/Oxygenflow(gingko,vinpocetine,VitaminE,HBOT)

• Insulinresistance(⬆adrenal/livereliminate

grains/sugars)

• Lossofbrainvolume(Gbrain,hypothlamus,CES,fats)

• Impairedneurotransmitterfunction

• Hormones(DHEA,estrogentestosterone

• Toxicaccumulations


Cognitive Function & Mood Elevation

• Coffee/BlackTeawithMCT/RawButter • Foods:Eggs,Liver • AminoAcids5-HTP(25-200mgs) • Glandulars:AdrenalbrainHypothalamus • Depression&Cognitionadd • Acetyl-Lcarnitine,GPCcholine(AlphaGlycerylphosphorylcholine)Gingko&Huperzine • (Note:somepeoplegetheadacheswithGingko)(notforuseduringpregnancy/lactation)


Cognitive Function

• Huperziaserrata/ChineseClubMoss

• HuperzineA,(acetylcholinesteraseinhibitor)moreacetylcholine,morememory&learning

• Bacopamonniera(Ayurvedicplant,Brahmi,waterhyssop)

• Acetyl-L-carnitine(ALCAR):crossbloodbrainbarrier—enhancesacetylcholine;nervegrowthfactorinbrain,aproteinForlearningandmemory.Boostbrainmetabolism

• Enhancescellularenergy,lowersinsulinresistance250-500mg(am)

• ALCARpotentiateswithalphaGPC(glycerophosphocholine)&RLipoicacid

• CombineHuperzine,R-Lipoicacid&ALCAR


Cognitive Function

• LithiumOrotate20-40mg/day

• RNA/DNA:enhancecognition,memory,TBI,circulation

• PhosphytidalserineregulatestheHPAaxis&supportsnervecelltransmission


Glandulars for Cognitive Function

•Brain •Hypothalamus&Pituitary •Adrenal •Liver(mood+anger)

•Heart•Thyroid


Sundowning / Late day confusion

• Sundowning:agitation,confusion&anxietyinlateafternoon/evening• Decreasedproductionofmelatonin,degenerationofsuprachiasmaticnucleus(SCN)thecircadian“pacemaker”ofhypothalamusjustaboveopticchiasma

• 2hrs.ofmorningbrightlighttherapy

• Melatonin

• CherryChamomilesmoothie

• Pituitary/Hypothalamus500-2000mg

• Cranial/Sacraltherapy&HandMassage

• Melissaaromatherapy


• Andropause

• LowT:

- Depression,irritability,lowlibido,bellygain

• PeriMenopause

• LowP:

- Sleep,irritability,anxiety,foggy

• Menopause

• LowP,EandT:

- Sleep,irritability,anxiety,depression,flashes,lowlibido,NT’sgodownwhenestrogengoesdown

Hormones


• Hypothyroid/Hyperthyroid• Cold,depressed/hot,anxious

• Testing&supplementation>referralstoprescribers…

• Women’sInternationalPharmacy

• CompoundingPharmacies

Hormones


• Drug–NutrientInteractionsVirtualDatabase• Usethisdatabasetoenteradrugorsupplement;receiveafullinteractionreportthatincludesnoticeofpotentialinteractions.Phone:800-931-17Web:http://www.integrativepro.com/Resources/Drug-Nutrient-Interaction-Checker• Book:Stargrove,M.B.,Treasure,J.,&McKee,D.L.(2007).Herb,nutrient,anddruginteractions:Clinicalimplicationsandtherapeuticstrategies.MarylandHeights,MI:Mosby

Databases


Databases

• RxISK• Freeandindependentwebsitewherepatients,doctors,andpharmacistscanresearchprescriptiondrugsandeasilyreportadrugsideeffect.Website:https://www.rxisk.org

• NutritionData• Detailednutritioninformation,plusuniqueanalysistoolsthattellyoumoreabouthowfoodsaffectyourhealthandmakeiteasiertochoosehealthyfoodsWebsite:http://nutritiondata.self.com/


Why Test?

• Testingincontext• Clientmaywantit

• Itmayimproveadherencetoaplan

• Testsmayconfirmwhatwebelieveorsuspect

• Illuminatenuances


• Vitamin D –depression, pain, immune function• Tissue Mineral Analysis (excess minerals heavy metals can

contribute to mental illness)• 24 hr diurnal cortisol• Hormone panels• Food sensitivities• Digestive Panels• Specialized testing: Walsh protocols, B-12, APOE genetic testing

Laboratory Testing for Mental Health Nutrition


• Homocysteine• High-sensitivity C-reactive protein (CRP): norms, under 0.55

mg/L in men & under 1.0 mg/L in women• Fibrinogen: 200–300 mg/dL

Inflammatory Markers in Blood Tests


• Simple way to test functional deficiency, common in eating disorders• Take a teaspoon full of liquid zinc & you will find that you

experience varying tastes based on your body’s current needs• Deficient in zinc, the liquid will taste like water• Adequate levels it will taste bitter

Zinc Taste Test


Lab Testing

118

• Neurogistics• ProvidestestsneurotransmitterlevelsPh:(888)257-9068;Fax:(888)236-9754;Email:[email protected];Website:http://www.neurogistics.com

• TraceElements,Inc.• Hairanalysislaboratory.4501SunbeltDr.,Addison,TX75001 Ph:(800)824-2314.Fax:(972)248-4896Website:http://www.traceelements.com

• Diagnos-Tech’s,Inc.• Fortestingfoodallergies,adrenalstress,male/femalehormonepanelsPh:(800)878-3787;Email:[email protected];Website:http://www.diagnostechs.com


• GlutenandFoodAllergy/FoodSensitivityTesting• CyrexTMspecializesintestingforautoimmuneconditions. Website:https://www.cyrexlabs.com/ Tests:https://www.cyrexlabs.com/CyrexTestsArrays/tabid/136/Default.aspx

• GreatPlainsLaboratory• Providesspecializedtesting,includingOrganicAcidstest,Gluten/Casein,VitaminD,aminoacidlevelstesting(urinaryandblood),urinary/serumpeptidetests,andzinctastetest. Website:http://www.greatplainslaboratory.com/home/eng/ Tests:https://www.greatplainslaboratory.com/select-a-test-2

Lab Testing


• LifeExtension• Providesrequisitionsforclient-orderedbloodtestsforavarietyofmarkers,includinginflammatorymarkers,homocysteine,high-sensitivityC-reactiveprotein(CRP),brinogen,andmicronutrienttests(blood). Website:http://www.lifeextension.com/Vitamins-Supplements/Blood-Tests

• TheMediatorReleaseTest• Testsforfood-andfood-chemical-inducedinflammation. Website:https://nowleap.com/the-patented-mediator-release-test-mrt/

Lab Testing


• SpectraCell• Providesnutritionaltesting,includingMTHFR,telomeretesting,micronutrienttests(blood),andnutrientstatusforphysiciansandtheirclients.SpectraCellLabsalsoconductstelomeretestingviabloodsamplesubmission. Website:http://www.spectracell.com/

Lab Testing


Omega 3 Index

• MeasureslevelsofEPA/DHAinthebloodcell

• Bloodspot/athometest

• https://omegaquant.com/about/

• https://omegaquant.com/omega-3-calculator/

• Calculateshowmuchdoseisneededfollowingtest

• Researchshowsaprox.1800/mg/dayminforclinicalresponse


Supplements Sources

123

• BioticsResearchCorporation• QualityNutritionalproducts. Ph:(800)636-6913;Fax:(800)863-9613;Website:http://www.bioticsnw.com

• EmersonEcologics• Provideshealthcareprofessionalswiththehighestqualitynutritionalsupplements. Ph:(800)654-4432;Fax:(800)718-7238;Email:[email protected];Website:http://www.emersonecologics.com


• CarlsonLabs• ExcellentsourceforvitaminEandfishoil.Website:http://www.carlsonlabs.com/

• IntegrativeTherapeutics• Website:http://www.integrativepro.com

• FungiPerfecti• Providesmedicinalmushroomsupplementsandproducts. Address:FungiPerfectiLLC,POBox7634,Olympia,WA98507;Phone(toll-freeinUS&Canada):800-780-9126;Phone(local):360-426-9292E-mail:[email protected]

Supplements Sources


Supplements Sources

125

• BioticsResearchCorporation• QualityNutritionalproducts. Ph:(800)636-6913;Fax:(800)863-9613;Website:http://www.bioticsnw.com

• EmersonEcologics• Provideshealthcareprofessionalswiththehighestqualitynutritionalsupplements. Ph:(800)654-4432;Fax:(800)718-7238;Email:[email protected];Website:http://www.emersonecologics.com


• AllergyResearchGroup• Excellentsourceofvitamins,minerals,andglandulars. Website:http://www.allergyresearchgroup.com/

Supplements Sources


• LifeExtension• Providesnutritionalinformation,products,andservices. Website:http://www.lef.org/

• LifeExtensionMagazine• AmonthlypublicationoftheLifeExtensionFoundationontopicsofnutrition,hormones,andantiagingsupplements. Website:http://www.lifeextension.com/magazine

• ThorneMetabolicNutrition• Qualitynutritionalsupplements. Website:https://www.thorne.com/

Supplements Sources and Information


• NordicNaturals• High-qualityshoilcombinationsforallages. Website:https://www.nordicnaturals.com

• StandardProcess• Excellentsourceofchlorophyllandglandulars. Website:http://www.standardprocess.com/home

Supplements Sources


• FullScript:35%offhighgradesupplements

• Signuphereand$50.00goestothecharityCWIS“NutrientsforNatives”program

• https://fullscript.com/practitioners/dr-leslie-korn

• EmersonEcologics35%offhighgradesupplements• Website:https://emersonecologics.com

Distributors Nutritional Supplements


• BastyrUniversityNutritionPrograms• BastyrUniversityoffersundergraduateandgraduatenutritiondegreeprograms,aswellasnondegreeprogramsthatencompassa“wholefood”approach.Address:BastyrUniversity,14500JuanitaDriveN.E.,Kenmore,WA98028-4966;Phone:(425)602-3000;Fax:(425)823-6222(fax); Website:http://www.bastyr.edu/academics/areas-study/study-nutrition

• HealthCoachTrainingProgram• IntegrativeNutrition’sHealthCoachTrainingProgramisonline,withlecturesbyleadinghealthexperts. Phone(US):(877)730-5444;Phone(International):+1(212)730-5433; Website:http://www.integrativenutrition.com/

Nutritional Therapies Training


• NationalAssociationofNutritionProfessionals(NANP)• ThiswebpageliststrainingprogramsthathavebeenreviewedandapprovedasmeetingNANP’seducationalstandards.Theseprogramsqualifytheirgraduatesforprofessionalmembershipandtositfortheholisticnutritionnationalboardexam. Website:https://www.nanp.org/list-of-schools

• NutritionalTherapyPractitionerProgram(NTP)• Thisdistance-learningprogramprovidesstudentswith9monthsofdistancetrainingwiththeflexibilityofself-pacedstudy,teleconferencecalls,andthreeseparatemultiple-day,instructor-ledworkshopsduringthe15-modulecourse.Website:https://www.nutritionaltherapy.com

Nutritional Therapies Training


• CenterforNutritionAdvocacy• TheCenterforNutritionAdvocacytracksnutritionalpracticeregulationforeachstate. Website:http://nutritionadvocacy.org/laws-state

• InternationalNetworkofIntegrativeMentalHealth,Inc.(NIMH)• Provideseducation,research,networking,andadvocacy. Website:http://www.inimh.org/

• Weston-PriceFoundation• Provideseducation,research,andactivismforrestoringnutrient-densefoodstothehumandiet.Website:http://www.westonaprice.org/

Organizations


• EthicalandLegalissuesofuseofnutritionalsupplements

• GoalsandDosingofsupplements

• ContraindicationsandDrugNutrientInteractions

• CoreNutrientsforMentalhealth

• WaterandFatSolubleVitamins;Minerals

• AminoacidsandNeurotransmitters

• ProtocolsofSpecialNutrients,Vitamins,MineralsGlandulars

• IntegrateBioidenticalHormonesforenhancedefficacy

Summary

Thank you!drlesliekorn.com [email protected]

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Nutritional Therapies for Mental Healthdrlesliekorn.com › wp-content › uploads › 2018 › 06 › 07... · bone or two if you have it) to the crock, add 2 cups of dry pinto beans