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Nutrartis Introduction

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Page 1: Nutrartis Introduction
Page 2: Nutrartis Introduction

“We value life, we provide natural heart health”

Steven HärtingCEO, Nutrartis S.A.

Page 3: Nutrartis Introduction

The chasm: from sterols to end-products

$200 B Market Health benefit High house hold

penetration (EU)

Proven to lower cholesterol

Limited supply

Formulation/logistics/regulatory hurdles

Fat content Limited food

categories

Page 4: Nutrartis Introduction

Market access made simple

Largest worldwide Non GMO Pure pine tree sterols

Commited to plant sterol innovation

Sub-micron dispersible sterols

$200 B Market Health benefit High house hold

penetration (EU)

Page 5: Nutrartis Introduction

plant sisters of cholesterolPhytostannols are hydrogenated sterols

Known and used to decrease LDLc

Phytosterols are

Page 6: Nutrartis Introduction

Versatile and easy to use(Can go into any food category without

affecting taste)

Clinically proven(Lowers LDL cholesterol and

triglycerides)

FAT / ALERGEN / GMO FREEFREE DISPERSIBLE STEROLS

Our products

Page 7: Nutrartis Introduction

1998: Esterified phytosterols• Low melting point (60ºC).• Soluble in lipid matrices.• Incorporates a fatty acid (rancidity, • higher energy intake).• Requires esterase activity in the

intestine.

2003: Dispersible free phytosterols• Fat free and dispersible in water.• Big size particles, precipitate.• Difficult to incorporate into food matrices .• Low cholesterol reduction efficiency.

• 95% of the market

• 85% Margarines

• <5% of the market

Phytosterols on the market

Page 8: Nutrartis Introduction

ANNEX

Other sterol ingredients

• Sterol esters

40% fatty acids, easily oxidized, limited applicability

• Other dispersible sterols:

Uncertain clinical effect, decanting, gritty

Page 9: Nutrartis Introduction

Diameter 50.0 1

Surface factor 1 2,500

NUTRARTIS Phytosterols

Page 10: Nutrartis Introduction

N16 – particle size distribution

Page 11: Nutrartis Introduction

N16 Sub-micron 16% sterol liquid dispersion (available today)

P80 80% sterol powder (available today)

N25 Concentrated version of N16 (available 1st quarter 2015)

PX Powder for direct comsumption (available 2nd quarter 2015)

(THROUGH PROPRIETARY TECHNOLOGY)

Our products

Page 12: Nutrartis Introduction

ApplicationsSoft drinks

Juice and juice drinksIced tea and coffe

Mixes

DairyCheese

CreamersDairy alternatives

YogurtMilk

Spreads

BakeryBiscuitsBreadCakesMixes

SupplementsLiquid sachet

Powder sachetTablets and softgels

CerealsBreakfast cereals

Energy and cereal barsOtherSauces and dressings

Ready mealsDesserts

And more!

Page 13: Nutrartis Introduction

Nutrartis clinical study

56 pubs in PubMed (Mar15) starting in 2008, mostly all PS

THE food centre together with Maastricht

Page 14: Nutrartis Introduction

References: Amir Shaghaghi, J.Funct.Food 2014, 280; Balk, , Atherosclerosis 2006, 19 ; Othman, Nut.Rev. 2011, 299

-30

-25

-20

-15

-10

-5

0

5

10

Nutrartis sterols Sterol esters Omega-3 Glucans

Clinical benchmark

TriglyceridesHDL

CholesterolLDL

CholesterolTotal

Cholesterol

HDL : Total Cholesterol

Ratio

Page 15: Nutrartis Introduction

Mechanism of action PS

Page 16: Nutrartis Introduction

1. A technically and clinically superior product

2. Simpler handling, new product development and processes

3. Assured supply of raw material through Arboris LLC

4. Technical, formulation and regulatory support

5. Technology licensing for cost-effective manufacturing

What we offer:

Page 17: Nutrartis Introduction
Page 18: Nutrartis Introduction

ANNEX

Labeling guidelines (general)

• Chile: Food labeling must comply with the technical rules on nutritional guidelines according to Resolución Exenta N° 764/09.

• Brazil: Foods must be registered in the category of “Alimentos com Alegações de Propriedade Funcional e ou de Saúde” and their efficacy proven according to regulations 18/99 and 19/99.

• European Union: Food labeling must comply with Commission Regulation (EC) No 608/2004.

• United States: Food labeling must comply with Regulation 21 CFR 101.83.

Page 19: Nutrartis Introduction

ANNEX

FOOD CATEGORY Liquid PowderBakeryBiscuits Bread Cakes Mixes

CerealsBreakfast cereals Energy bars

SupplementsSachets Tablets and softgels

Other

FOOD CATEGORY Liquid PowderSoft drinksJuice and juice drinks

Iced tea and coffee  Mixes

DairyCheese  Creamers  Dairy alternative  Yogurt Milk  Spreads  

Product / application


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