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High-‐Resolu,on MicroCT Imaging & Image Analysis Services
Specialty Preclinical CRO Numira combines innova,ve tools and technologies to provide unique solu,ons to a wide variety of preclinical drug discovery efforts. By choosing Numira as your CRO, you get more informa,on from each specimen and answers faster than ever before, saving your team valuable ,me and resources. Let us demonstrate the feasibility of our novel technology through a small, low-‐cost pilot study. Accelerating Drug Discovery
§ Bone: Car,lage and osteochondral defects, developmental biology, biologics, orthopedics (drill, segmental, and window defects, closed fracture, and spinal bone fusion models), osteoarthri,s, osteoporosis, rheumatoid arthri,s
§ Pulmonary: Fibrosis, COPD/emphysema, pulmonary arterial hypertension, lung tumors
§ Cardiovascular: Atherosclerosis, septal defects, stents within coronary arteries
§ Vasculature: Vascular imaging and analysis of tumors and any/all organs, including bone vasculature
§ Biomedical Devices: Metallic and non-‐metallic stents/devices, wound healing material, bone implant material (organic and inorganic)
§ Image Analysis: Analysis using proprietary algorithms for microCT, MRI, ECG, and histology data
Our proprietary so2 3ssue contrast agent will stain a variety of 3ssue and lesions and is non-‐destruc3ve. The same 3ssue can be re-‐analyzed via histology to further characterize the observed 3ssue or lesions.
Osteoarthri,s Rheumatoid Arthri,s Pulmonary Cardiovascular Vasculature
Specialized Histology Services (GLP or non-‐GLP)
§ RouDne & Specialized Histology: Plas,c, paraffin, frozen, EXAKT ground sec,ons
§ Histopathology: CNS, bone, oncology, pulmonary, gastrointes,nal, renal
§ Histomorphometry: GLP-‐validated Osteomeasure systems
§ Immunohistochemistry (IHC): Custom stain development, co-‐expression and double labeling
§ ExperDse in ocular, renal, and CNS histology services
Coronary Stent (Masson's Trichrome)
Rat Tibia Growth Plate (Safranin O)
Rat Kidney (Glepp-‐1)
Mouse Eye (CD4)
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Corporate Headquarters 420 E South Temple, St 520 Salt Lake City, UT 84111 (801) 320-‐0682 www.numira.com [email protected]
3D Oncology Cell Screening Services
§ 60+ Cell Lines
§ 3D format in 384 well plates
§ 9-‐point dose response in quadruplicate
§ Staurosporine controls on every cell line
§ ProliferaDon and Apoptosis assays (reported values: EC50, IC50 and GI50)
§ Combina,on Screens – 5x5 or custom matrix
§ Combina,on index and Bliss analysis
§ Analysis available on all 60 cell lines or a la carte
HCT 116 Hep G2 647-‐V HT-‐29 DLD-‐1
AltaNexus – Cloud-‐based Project Management Services
Numira’s cloud-‐based data management plakorm was designed specifically for the life sciences community to manage projects and explore project data and documents.
§ Secure: Authen,cated logins, encrypted storage, and secure web-‐connec,ons
§ Data access: Searchable, sortable data organized by project and specimen
§ High speed: Instant access to every aspect of your data
§ No limits: Unlimited data storage, unlimited upload and download bandwidth
§ Document previews: View Office documents in the browser
§ Media streaming: Play content directly in your browser
3D cultures are bemer predictors of in vivo biology and pharmacology than 2D cultures, allowing for the screening of large number of compounds for efficacy before tes,ng in more costly and ,me consuming in vivo xenogran studies.
NUMIRA
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