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HighResolu,on MicroCT Imaging & Image Analysis Services Specialty Preclinical CRO Numira combines innova,ve tools and technologies to provide unique solu,ons to a wide variety of preclinical drug discovery efforts. By choosing Numira as your CRO, you get more informa,on from each specimen and answers faster than ever before, saving your team valuable ,me and resources. Let us demonstrate the feasibility of our novel technology through a small, lowcost pilot study. Accelerating Drug Discovery Bone: Car,lage and osteochondral defects, developmental biology, biologics, orthopedics (drill, segmental, and window defects, closed fracture, and spinal bone fusion models), osteoarthri,s, osteoporosis, rheumatoid arthri,s Pulmonary: Fibrosis, COPD/emphysema, pulmonary arterial hypertension, lung tumors Cardiovascular: Atherosclerosis, septal defects, stents within coronary arteries Vasculature: Vascular imaging and analysis of tumors and any/all organs, including bone vasculature Biomedical Devices: Metallic and nonmetallic stents/devices, wound healing material, bone implant material (organic and inorganic) Image Analysis: Analysis using proprietary algorithms for microCT, MRI, ECG, and histology data Our proprietary so2 3ssue contrast agent will stain a variety of 3ssue and lesions and is nondestruc3ve. The same 3ssue can be re analyzed via histology to further characterize the observed 3ssue or lesions. Osteoarthri,s Rheumatoid Arthri,s Pulmonary Cardiovascular Vasculature Specialized Histology Services (GLP or nonGLP) RouDne & Specialized Histology: Plas,c, paraffin, frozen, EXAKT ground sec,ons Histopathology: CNS, bone, oncology, pulmonary, gastrointes,nal, renal Histomorphometry: GLPvalidated Osteomeasure systems Immunohistochemistry (IHC): Custom stain development, coexpression and double labeling ExperDse in ocular, renal, and CNS histology services Coronary Stent (Masson's Trichrome) Rat Tibia Growth Plate (Safranin O) Rat Kidney (Glepp1) Mouse Eye (CD4)

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High-­‐Resolu,on  MicroCT  Imaging  &  Image  Analysis  Services  

Specialty  Preclinical  CRO  Numira   combines   innova,ve   tools   and   technologies   to   provide   unique  solu,ons  to  a  wide  variety  of  preclinical  drug  discovery  efforts.  By  choosing  Numira  as   your  CRO,   you  get  more   informa,on   from  each   specimen  and  answers   faster   than   ever   before,   saving   your   team   valuable   ,me   and  resources.   Let   us   demonstrate   the   feasibility   of   our   novel   technology  through  a  small,  low-­‐cost  pilot  study.   Accelerating Drug Discovery

§  Bone:  Car,lage  and  osteochondral  defects,  developmental  biology,  biologics,  orthopedics  (drill,  segmental,  and  window  defects,  closed  fracture,  and  spinal  bone  fusion  models),  osteoarthri,s,  osteoporosis,  rheumatoid  arthri,s  

§  Pulmonary:  Fibrosis,  COPD/emphysema,  pulmonary  arterial  hypertension,  lung  tumors  

§  Cardiovascular:  Atherosclerosis,  septal  defects,  stents  within  coronary  arteries  

§  Vasculature:  Vascular  imaging  and  analysis  of  tumors  and  any/all  organs,  including  bone  vasculature  

§  Biomedical  Devices:  Metallic  and  non-­‐metallic  stents/devices,  wound  healing  material,  bone  implant  material  (organic  and  inorganic)  

§  Image  Analysis:  Analysis  using  proprietary  algorithms  for  microCT,  MRI,  ECG,  and  histology  data  

Our  proprietary  so2  3ssue  contrast  agent  will  stain  a  variety  of  3ssue  and  lesions  and  is  non-­‐destruc3ve.  The  same  3ssue  can  be  re-­‐analyzed  via  histology  to  further  characterize  the  observed  3ssue  or  lesions.    

Osteoarthri,s   Rheumatoid  Arthri,s   Pulmonary   Cardiovascular   Vasculature  

Specialized  Histology  Services  (GLP  or  non-­‐GLP)  

§  RouDne  &  Specialized  Histology:  Plas,c,  paraffin,  frozen,  EXAKT  ground  sec,ons  

§  Histopathology:  CNS,  bone,  oncology,  pulmonary,  gastrointes,nal,  renal  

§  Histomorphometry:  GLP-­‐validated  Osteomeasure  systems  

§  Immunohistochemistry  (IHC):  Custom  stain  development,  co-­‐expression  and  double  labeling  

§  ExperDse  in  ocular,  renal,  and  CNS  histology  services  

Coronary  Stent    (Masson's  Trichrome)    

Rat  Tibia  Growth  Plate  (Safranin  O)  

Rat  Kidney  (Glepp-­‐1)  

Mouse  Eye  (CD4)  

©    2014  Numira  Inc.  All  Rights  Reserved.                                                                                                    

Corporate  Headquarters  420  E  South  Temple,  St  520  Salt  Lake  City,  UT  84111  (801)  320-­‐0682  www.numira.com  [email protected]  

3D  Oncology  Cell  Screening  Services  

§  60+  Cell  Lines  

§  3D  format  in  384  well  plates  

§  9-­‐point  dose  response  in  quadruplicate  

§  Staurosporine  controls  on  every  cell  line  

§  ProliferaDon    and  Apoptosis  assays  (reported  values:  EC50,  IC50  and  GI50)  

§  Combina,on  Screens  –  5x5  or  custom  matrix  

§  Combina,on  index  and  Bliss  analysis  

§  Analysis  available  on  all  60  cell  lines  or  a  la  carte  

HCT  116   Hep  G2   647-­‐V   HT-­‐29   DLD-­‐1  

AltaNexus  –  Cloud-­‐based  Project  Management  Services  

Numira’s  cloud-­‐based  data  management  plakorm  was  designed  specifically  for  the  life  sciences  community  to  manage  projects  and  explore  project  data  and  documents.    

§  Secure:  Authen,cated  logins,  encrypted  storage,  and  secure  web-­‐connec,ons  

§  Data  access:  Searchable,  sortable  data  organized  by  project  and  specimen  

§  High  speed:  Instant  access  to  every  aspect  of  your  data  

§  No  limits:  Unlimited  data  storage,  unlimited  upload  and  download  bandwidth  

§  Document  previews:  View  Office  documents  in  the  browser  

§  Media  streaming:  Play  content  directly  in  your  browser  

3D  cultures  are    bemer  predictors  of  in  vivo  biology   and   pharmacology   than   2D  cultures,   allowing   for   the   screening   of  large     number   of   compounds   for   efficacy  before   tes,ng   in   more   costly   and   ,me  consuming  in  vivo  xenogran  studies.  

NUMIRA

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