Nucleophilic substitution

1

Functional group transferation

2

3

Alkyl halides; Alkenyl halides; Aryl halides

4

5

6

Relative reactivity of halides leaving groups

7

Substitution nucleophilic bimolecular

SN2 Mechanism

8

Direct displacement

Stereochemistry of SN2 reaction

Inversion of configuration

9

10

11

How SN2 reaction occur

12

Steric effects in SN2 reactions

13

14

15

16

Nucleophile and nucleophilisity

17

18

19

20

Substitution nucleophilic unimolecular

21

Mechanism of SN1 reactions; Stability of carbonations

22

23

24

Stereochemistry of SN1

25

Carbocation stability

26

27

28

29

30

31

32

33

34

35

36

37

38

39

40

41

42

43

44