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THE BIG DATA
CHALLENGE
BRETT POWERS , DAVID SHRAYBER, CHRISTINA LAM
INTRODUCTION Hypoxia: Oxygen Concentration < 85%
Bradycardia: > 0.6 seconds/beat
Apnea: Breathing rate > 10 sec
1st HYPOTHESISThe QRS variability can be used as a marker to detect hypoxia.
- QRS complex
- Code
- Findings
- Machine Learning
QRS COMPLEX - ECG can measure apnea and
bradycardia through the R-R interval.
- QRS complex amplitude precursor
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2831912/?report=printable
CODE
CODE
● Peak and Trough detection
● Interpolation
Chaotic Variability
Stable
Chaotic
Peak - Trough Distance
Stable
Amplitude
10 minutes - 15 minutes
10 minutes - 15 minutes
Stable2.25 minutes
2 hours 20 minutes - 2 hours 28 minutes
5 hours 37 minutes - 5 hours 43 minutes
15 hours 45 minutes - 15 hours 57 minutes
Whoa……..
Random blind test on a hypoxia showed similar precursors.
Blind Test 2
Nailed It!
Blind Test 2
Baby 1801 Test
MACHINE LEARNING
2nd Hypothesis Detecting the REM cycle by an ECG reading in conjunction with the abdominal movements, apnea can be predicted.
http://pediatrics.aappublications.org.sci-hub.ac/content/57/1/142?variant=short&sso=1&sso_redirect_count=1&nfstatus=401&nftoken=00000000-0000-0000-0000-000000000000&nfstatusdescription=ERROR%3a+No+local+token
REM sleep inhibits mechanisms that affect the respiratory system.
REM Sleep → Difficulties in breathing for preterm babies.
Ideas
RESEARCH Premature babies spend a lot of time in REM sleep.
Therefore, Apnea usually occurs during the REM cycle.
Arousal from REM sleep may trigger or precursor to apnea and hypoxia.
Since moter activities after being woken up are grouped together with laryngeal closure
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158333/pdf/431_2011_Article_1409.pdf
Taking EEG readings and correlating them with the ECG readings, we can find some markers before REM sleep.
Thank You For Being Awesome!
Dr. IndicDr. PaydarfarAlan Gee (Cal Tech Guy)Spon 1502Spon 1801Spon 1301
Questions