Nov 23, 20061st presentation1 Work done by: Turma 9 Guiding Professor: Dra. Cristina Santos Faculdade de Medicina da Universidade do Porto Introdução à

Nov 23, 2006 1st presentation 1

WorkWork done done byby:: Turma 9Turma 9

GuidingGuiding Professor: Professor:

Dra. Cristina SantosDra. Cristina Santos

Faculdade de Medicina da Universidade do PortoFaculdade de Medicina da Universidade do Porto

Introdução à MedicinaIntrodução à Medicina


Accuracy and completeness of Accuracy and completeness of reporting of studies of diagnostic reporting of studies of diagnostic accuracy in infectious diseases accuracy in infectious diseases

literatureliterature

Meta-analysisMeta-analysis First PresentationFirst Presentation

Faculdade de Medicina da Universidade do Faculdade de Medicina da Universidade do Porto Porto



IntroductionIntroduction




A rigorous evaluation process of diagnostic tests before introduction into clinical practice could:

• Reduce the number of unwanted clinical consequences related to misleading estimates of test accuracy [1]

• Limit health care costs by preventing unnecessary testing [1]

[1] (Bossuyt PM, Reitsma JB, Bruns DE, Gatsonis CA, Glasziou PP, Irwig LM, Lijmer JG, Moher D, Rennie D, de Vet HC: Towards complete and accurate reporting of studies of diagnostic accuracy, the STARD initiative. Clinical Chemistry 2003, 49:1-6.)




• The term accuracy refers to the amount of agreement between the information from the test under evaluation and the reference standard. [1]

• Diagnostic accuracy can be estimated in several ways: sensitivity, specificity, receiver operating characteristic curves (ROC), positive and negative predictive values, likelihood ratios, and diagnostic odd ratios. [2]

• Several meta-analysis studies have emphasized the poor quality of research reports. [3]

• [1] (Bossuyt PM, Reitsma JB, Bruns DE, Gatsonis CA, Glasziou PP, Irwig LM, Lijmer JG, Moher D, Rennie D, de Vet HC: Towards complete and accurate reporting of studies of diagnostic accuracy, the STARD initiative. Clinical Chemistry 2003, 49:1-6.)

• [2] (M A R Siddiqui, A Azuara-Blanco, J Burr: The quality of reporting of diagnostic accuracy studies published in ophthalmic journals. Br J Ophthalmol 2005, 89:261-265)

• [3] (Smidt N, Rutjes AWS, Van der Windt AWM, Ostelo RWJG, Reitsma JB, Bossuyt PM, Bouter LM, De Vet HCW: Reproducibility of the STARD checklist: an instrument to assess the quality of reporting of diagnostic accuracy studies. BMC Medical Research Methodology 2006, 6:12.)




AimAim

• Evaluate the quality of reporting of all diagnostic studies in infectious diseases literature between 1999 and 2005 using the Standards for Reporting of Diagnostic Accuracy (STARD) initiative parameters.

• Compare the studies of diagnostic accuracy in infectious diseases literature based on STARD statement (2003)"




STARDSTARD

• To improve the quality of reporting of diagnostic accuracy studies the Standards for Reporting of Diagnostic Accuracy (STARD) was published. [1]

• The STARD project group developed a checklist of 25 items and a prototypical flow chart to represent the design of the study and the flow of patients through the study. [1]

[1] (Bossuyt PM, Reitsma JB, Bruns DE, Gatsonis CA, Glasziou PP, Irwig LM, Lijmer JG, Moher D, Rennie D, de Vet HC: Towards complete and accurate reporting of studies of diagnostic accuracy, the STARD initiative. Clinical Chemistry 2003, 49:1-6.)






MethodsMethods




Research StrategyResearch StrategyBibliographic data base: MEDLINE

Journal selection based on:

• A table regarding the “Top 50 Journals That Frequently Publish Articles on Diagnostic Accuracy – 8 journals [4]

• The impact factor of journals on infectious diseases retrieved “ISI Web

of Knowledge” (2005) – 5 journals

13 journals with impact factor greater than 5 were selected• [4] (Smidt N, Rutjes AWS, Van der Windt AWM, Ostelo RWJG, Reitsma JB, Bossuyt PM, Bouter LM, De Vet HCW: Quality of reporting of diagnostic accuracy studies. Radiology 2005,

235:347-353.)





Tabela do ISIknowledge


Query used on Pub MEDQuery used on Pub MED

(((((((("sensitivity and specificity"[All Fields] OR "sensitivity and specificity/standards"[All Fields]) OR "specificity"[All Fields]) OR "screening"[All Fields]) OR "false positive"[All Fields]) OR "false negative"[All Fields]) OR "accuracy"[All

Fields]) OR (((("predictive value"[All Fields] OR "predictive value of tests"[All Fields]) OR "predictive value of tests/standards"[All Fields]) OR "predictive values"[All Fields]) OR "predictive values of tests"[All Fields])) OR

(("reference value"[All Fields] OR "reference values"[All Fields]) OR "reference values/standards"[All Fields]) OR ((((((((((("roc"[All Fields] OR "roc analyses"[All Fields]) OR "roc analysis"[All Fields]) OR "roc and"[All Fields]) OR "roc

area"[All Fields]) OR "roc auc"[All Fields]) OR "roc characteristics"[All Fields]) OR "roc curve"[All Fields]) OR "roc curve method"[All Fields]) OR "roc curves"[All Fields]) OR "roc estimated"[All Fields]) OR "roc evaluation"[All Fields]) OR

("likelihood ratio"[All Fields])) AND ("Circulation"[Jour] OR Lancet[Jour] OR "BMJ (Clinical research ed.)"[Jour] OR "The New England journal of medicine"[Jour] OR "Archives of internal medicine"[Jour] OR "Annals of internal

medicine"[Jour] OR "Gut"[Jour] OR "JAMA : the journal of the American Medical Association"[Jour] OR "The Lancet infectious diseases"[Jour] OR "Clinical infectious diseases : an official publication of the Infectious Diseases Society of

America"[Jour] OR "AIDS (London, England)"[Jour] OR "Emerging infectious diseases"[Jour] OR "Antiviral

therapy"[Jour])

17131 papers were retrieved




Pos-STARD(2004 to 2005)

1524 articles

Pre-STARD(1999 to 2002)

3336 articles



ArticlesArticles

Total: 4860 articles























Gantt ChartGantt Chart







The EndThe End






Documents

Nov 23, 20061st presentation1 Work done by: Turma 9 Guiding Professor: Dra. Cristina Santos Faculdade de Medicina da Universidade do Porto Introdução à