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Norquay Technology Inc.
Moving forward, in
Fine & Specialty ChemicalsP.O. Box 468Chester, PA 19016 USA
phone: +1(610) 874-4330fax: +1(610) 874-3575
www.NorquayTech.com
www.NorquayTech.com 2
today’s discussion
Overview Custom Synthesis Seven (7) Day Guarantee Equipment Product Lines
Contact Information
www.NorquayTech.com 3
Roach’s Shipyard, old Chester Harbor, 1859-1885
Chester Waterfront ca 1875
1927-1961
www.NorquayTech.com 4
The
Chester plant
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Norquay TechnologyChester plant
1927-1961
6
Norquay Overview
Founded 1987: Philadelphia, PA Focus
Niche MarketsHigh Value-added $15.00 - $42,000/kgKilo-Lab: 10 grams to 20 kgLow Volume 50 kg to 85+tpyCommercial Scale 100-1,500 gal
Products Sales Custom Synthesis: 50% Product Line: 50% Export: 30%:
Europe, South America, Japan & Asia
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7
Seamless Scale-up
Laboratory, Kilo-lab,
Pilot PlantCommercial Quantities
Compound pricing studies, Economic Model
Confidentiality Agreements
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8
Equipment
Kilo Lab: ( 5-12-22-30-50 liter)
Plant Reactors: jacketed, condensers & instrumentation Hastelloy –C-276:20-100-350 gal 316 Stainless Steel: 500-1,500 gal Glass Lined: 100-500-750-1,000 gal
Vacuum Distillation: 50 liter to 100-500-1,500 gal <1.0 torr 10 – 25 theoretical plates
Filter-Drying: air & moisture sensitive
Drying: shelf, double-cone & rotary (316 s/s)
Utilities: -78° to 170o C (future to 220o C)
Analytical: HPLC, GC, NMR, UV, L-a-b color, Karl Fischer, etc.
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Formal Response “Yes” or “No” within Seven (7) Days
9
NORQUAY: Seven (7) Day Guarantee
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Project Defined, unequivocally
Chemical Name, CAS Number
Scope Volume, Timing, Stage GATE Process
How is Success measured? (Step 3)
Outline Open IssuesTSCA LVE or REACh for Europe
Customer Clarifying Questions Key Parameters, measure of SUCCESS Analytical Methods- Need development?Alignment between customer “ Use Test” & QC Methods
TimingQuote to first lab sample <?>Qualification (3 lots?)Steps to commercial scale?
10
NORQUAY: Seven (7) Day Guarantee
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www.NorquayTech.com 11
NQ: Product Lines
؏ Substituted Benzophenones ؏ Phenylhydrazines & Indoles ؏ Cyanoacetates ؏ Heterocycles ؏ Metallocenes, cp-ligands ؏ HPLC/Process Surfactants: Sulfonates ؏ Chlorendate Esters
To Contents
12
Benzophenonesbenzophenone CAS #
1 . 2,4- Dihydroxy benzophenone 131-56-62 . 2,2',4,4'- Tetrahydroxy benzophenone 131-55-53 . 2- Hydroxy -4-allyloxy benzophenone 2549-87-34 . 2- Hydroxy -4-methoxy benzophenone 131-57-75 . 2- Hydroxy -4-methoxy benzophenone -5-sulfonic Acid 4065-45-66 . 2,2'- Dihydroxy -4,4'-dimethoxy benzophenone 131-54-47 . 2,2'- Dihydroxy -4-methoxy benzophenone 131-53-38 . 2,2'- Dihydroxy -4,4'-dimethoxy benzophenone -5,5'-disulfonic Acid Na Salt 76656-36-5
2,2'4,4'- Tetrahydroxy benzophenone2,2'- Dihydroxy -4,4'-dimethoxy benzophenone
bis (2,4- Dihydroxy phenyl) methanonebis (2- Hydroxy-4-methoxyphenyl) methanone
13 . 2- Hydroxy -4-octyloxy benzophenone 1843-05-614 . 4,4'- Difluoro benzophenone 345-92-615 . 4,4'- Dimethoxy benzophenone 90-96-016 . 4,4'- Dimethyl benzophenone 611-97-217 . 2,4- Dimethyl benzophenone 1140-14-318 . 4- Fluoro benzophenone 345-83-519 . 4- Morpholino benzophenone 24758-49-4
sulfonic acid
9
9
.
.
substituents
1341-54-4
1341-54-4
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13
Benzophenones
O
OOH
OH
OOH
OH
OH
OH
OOH
O
CH2
OOH
O
OH
OCH3 CH3
OOH
OCH3
OOH
O
OH
CH3
OOH
OCH3
SO3H
O OH
OC8H17
O
F F
O
CH3 CH3
O
O OCH3 CH3
OCH3
CH3
O
F
O
N
O
OOH
O
OH
OCH3 CH3
SO3-Na
+SO3
-Na
+
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O OH
OCH3
SO3H
O OH
OCH3
O OH
OH
PRODUCT OVERVIEW
Primary Use Solubility UV Spectrum (g Product / 100ml Solvent) (30°C)
Helisorb-1 (Benzophenone-1) 2,4-Dihydroxybenzophenone • Cosmetics Water: Insoluble Bath Preparations Methanol: 32.0 Shampoos Ethanol: 32.0 Blushes Nail Polish / Enamel • Paints • Plastics WAVELENGTH λ max: 292/330nm
Helisorb-3 (Benzophenone-3) 2-Hydroxy-4-methoxybenzophenone
• Cosmetics Bath Preparations Water: Insoluble Colognes / Perfumes Methanol: 6.0 Sunscreens Ethanol: 6.0 • Paints • Plastics WAVELENGTH λ max: 285/320nm
Helisorb-4 (Benzophenone-4) 2-Hydroxy-4-methoxybenzophenone- 5-sulfonic acid • Cosmetics Water: 28.0 Bath Preparations Methanol: 40.0 Fragrances, Cologne Ethanol: 35.0 Hair Care Blushes Skin Care • Paints • Plastics WAVELENGTH λ max: 285/320nm
UV-C UV-B UV-A
80%
20%
UV-C UV-B UV-A
40%
20%
UV-C UV-B UV-A
20%
% T
RA
NS
MIT
TA
NC
E
100%
40%
0% 240 260 280 300 320 340 360 380 400
% T
RA
NS
MIT
TA
NC
E
100%
80%
60%
0% 240 260 280 300 320 340 360 380 400
% T
RA
NS
MIT
TA
NC
E
100%
80%
60%
40%
240 260 280 300 320 340 360 380 400
10mg/l 20mg/l 40mg/l
60%
0%
Helisorb-11 (2,2’-Dihydroxy-4,4’-dimethoxybenzophenone)
(Benzophenone-6)
• Cosmetics Water: Insoluble Nail Polish Methanol: <1.0 Nail Enamels Ethanol: <1.0• Plastics• Films
Helisorb-11DS (2,2’-Dihydroxy-4,4’-dimethoxybenzophenone-
(Benzophenone-9) 5,5’-disulfonic acid sodium salt)
Bath Preparations Water: 5.0 Hair Cosmetics Methanol: 2.0 Shampoos Ethanol: 1.0 Skin Products
Helisorb-10 (2,2’,4,4’-Tetrahydroxybenzophenone)
(Benzophenone-2)
• Cosmetics Water: .10 Toilet Water Methanol: 50.0 Fragrances Ethanol: 40.0 Perfumes Shampoos Skin Products• Plastics / Paints
OOH
OH
OH
OH
OOH
O
OH
OCH3 CH3
OOH
O
OH
OCH3 CH3
SO3-Na
+SO3
-Na
+
To Contents
www.NorquayTech.com 15
Phenylhydrazines
CH3
NHNH2
ClH
F
NHNH2
ClH
NHNH2
F
ClH
NH
NH2
Br
ClH
Cl
NHNH2
ClH
NHNH2
Cl
ClH
NHNH2
Cl
Cl
ClH
NHNH2
CH3
ClH
NHNH2
CH3
ClHNH
NH2
CH3
ClH
Br
NHNH2
ClH
O
NH
NH2
CH3
ClH
CH3
NH NH2
CH3
ClH
N
NH2ClH
To Contents
Phenyl hydrazine CAS #
1 . 2- Bromo phenyl hydrazine HCl 50709-33-6
2 . 4- Bromo phenyl hydrazine HCl 41931-18-4
3 . 2- Chloro phenyl hydrazine HCl 41052-75-9
4 . 4- Chloro phenyl hydrazine HCl 1073-70-7
5 . 2,4- Di chloro phenyl hydrazine HCl 5446-18-4
6 . 3,5- Di chloro phenyl hydrazine HCl 63352-99-8
7 . 3,4- Di methyl phenyl hydrazine HCl 60481-51-8
8 . 1,1- Di phenyl hydrazine HCl 530-47-2
9 . 2- Ethyl phenyl hydrazine HCl 19398-06-2
10 . 2- Fluoro phenyl hydrazine HCl 2924-15-4
11 . 4- Fluoro phenyl hydrazine HCl 823-85-8
12 . 4- Methoxy phenyl hydrazine HCl 19501-58-7
13 . 2- Tolyl hydrazine HCl 635-26-7
14 . 3- Tolyl hydrazine HCl 637-04-7
15 . 4- Tolyl hydrazine HCl 637-60-5
Substitution
16
Specialty Cyanoacetates
for: Specialty Adhesives Medical devices Disposable Components
NCO-R
O
NCO
O
CH3
NCO
O
CH3
NCO
O
CH3
NCO
O
CH3
NCO
O
CH3
CH3
NCO
O
CH3
CH3
NCO
O
CH3
CH3
NCO
OCH3
CH3
NCO
O
OCH3
NCO
O
CH3
CH3
O-CH3
NCO
OO CH3
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17
Specialty Cyanoacetates
cyanoacetate CAS1 . n- Propyl cyanoacetate 14447-15-52 . n- Hexyl cyanoacetate 13361-53-03 . n- Octyl cyanoacetate 15666-97-44 . n- Decyl cyanoacetate 17686-43-05 . Isopropyl cyanoacetate 13361-30-36 . Isobutyl cyanoacetate 13361-31-47 . Isoamyl cyanoacetate 60180-49-68 . 2- Octyl cyanoacetate 52688-08-19 . "2- Methoxyethyl" cyanoacetate 10258-54-5
10 . "2- Methoxyisopropyl" cyanoacetate 32804-79-811 . "2- Ethoxyethyl" cyanoacetate 32804-77-6
substituent
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18
Heterocycles
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www.NorquayTech.com 19
Heterocycles
N
N
OH
N
H3C-O O
O
O-CH3H3C-O
N
O
SH
O
H3C-O
H3C-OO
O-CH3
O-CH3
NH
NH
O
N
NH
OH
S
NH
CH3
CH3
S
NH
CH3
F
To Contents
CAS # Chemical Name2 . 5,6-dimethoxy indanone 2107-69-9 5,6-dimethoxyindanone3 . 2,5-Dimethyl benzothiazole 95-26-1 2,5-Dimethylbenzothiazole4 . 5-Fluoro-2-methyl benzothiazole 399-75-7 5-Fluoro-2-methylbenzothiazole1 . 2- Benzoxazole thiol 2382-96-9 2-Benzoxazolethiol5 . 2-Hydroxy benzimidazole 615-16-7 2-Hydroxybenzimidazole6 . 3,6-Dimethoxy xanthone 1214-24-0 3,6-Dimethoxyxanthone7 . 6-Hydroxy quinoline 580-16-15 6-Hydroxyquinoline8 . 6-Methoxy quinoline 5263-87-6 6-Methoxyquinoline9 . Julolidine 479-59-4 Julolidine
Chemical Name
20
etallocenes, Ligands
metallocene CAS #1 . 5-Hexene-2-one 109-49-92 . Vinyl cyclohexane 695-12-53 . 1,4-Bis(1-hydroxycyclopentyl) butadiyne 104766-62-34 . t-Butyl cyclopentadiene 41539-65-55 . Diphenyl fulvene 2175-90-86 . 1,2,3,4-Tetramethyl cyclopentadiene 4249-10-97 . 1,2,3,4,5-Pentamethyl cyclopentadiene 4045-44-78 . Ferrocene tech 102-54-59 . Acetyl ferrocene 1271-55-2
10 . Vinyl ferrocene 1271-51-811 . 1,1-Bis(diphenyl phosphino) ferrocene 12150-46-812 . 1,1-Bis(diphenyl phosphino) ferrocene Pd (II) dichloride 72287-26-413 . Pentamethyl cyclopentadiene titanium trimethoxide 123927-75-314 . Pentamethyl cyclopentadiene titanium trichloride 12129-06-515 . 1-dimethyl- 2,3,4,5-Tetramethyl cyclopentadiene silyl t-butylamine 125542-04-316 . 2,3,4,5-Tetramethylcyclopentadienyldimethylsilyl-t-butylamido titanium dichloride 135072-61-6
Ligand
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CAS # Chemical Name109-49-9 5-Hexene-2-one695-12-5 Vinylcyclohexane
104766-62-3 1,4-Bis(1-hydroxycyclopentyl) butadiyne41539-65-5 t-Butylcyclopentadiene2175-90-8 Diphenylfulvene 4249-10-9 1,2,3,4-Tetramethylcyclopentadiene4045-44-7 1,2,3,4,5-Pentamethylcyclopentadiene102-54-5 Ferrocene (Technical Grade)
1271-55-2 Acetylferrocene1271-51-8 Vinylferrocene12150-46-8 1,1-Bis(diphenylphosphine) ferrocene72287-26-4 1,1-Bis(diphenylphosphine) ferrocene Palladium chloride
123927-75-3 Pentamethylcyclopentadiene titanium trimethoxide12129-06-5 Pentamethylcyclopentadiene titanium trichloride
125542-04-3 2,3,4,5-Tetramethylcyclopentadiene-1-dimethylsilyl-t-butylamine135072-61-6 2,3,4,5-Tetramethylcyclopentadienyldimethylsilyl-t-butylamido titanium dichloride
www.NorquayTech.com 21
etallocenes, Ligands
CH3
CH3
CH3
CH3
CH3
CH3 CH3
Si
CH3
CH3
NHCH3
CH3
CH3
To Contents
22
Alkyl Sulfonates
HPLC: high purity Reagent Grade Industrial surfactants Dial-In properties
From C-2 to C-16Salts; Na, K, Li etc
Alkyl sulfonic acidsSodium <25 – 50 ppm
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23
Alkyl Sulfonates (& their free acids)
SO3Na • H2Oor
CH3(CH2)7SO3Na • H2O
SO3Na
or
CH3(CH2)15SO3Na
CH3 (CH2)3 SO3Na
SO3Na
or
1-Butane sulfonic acid sodium salt
1-Hexadecane sulfonic acid sodium salt
1-Octane sulfonic acid sodium salt monohydrate
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24
Tentative Specifciations Appearance slightly yellow transparent liquid
Color (APHA): max 700 Acid value (mg KOH/g): < 0.1Assay: Develop GC method PropertiesSpecific gravity (20°C): 1.380 - 1.400 g/ccEster value (mg KOH/g): 223 (no limit)Refractive Index (25°C): 1.512 (no limit)
Chlorendate- DBC
ClCl
Cl
Cl
Cl
ClO-nBu
O
O
O-nBu
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25
Chlorendate- DEC, DBC, DEHC
ClCl
Cl
Cl
Cl
Cl
O
O
O
O
CH3
CH3
ClCl
Cl
Cl
Cl
ClO-nBu
O
O
O-nBu
ClCl
Cl
Cl
Cl
Cl
O
O
O
O
CH3
CH3
CH3
CH3
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26
Contact Us
Business DevelopmentRobert W. Heldt PresidentTel +1(610) 874-4330Fax +1(610) 874-3575 [email protected]
Sales & MarketingJohn C. Wetzel, Ph.D.Director of Sales & MarketingTel +1(610) 874-4330Cell +1(803) [email protected]
For more information contact:
cell +1(610) 945-8676
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