1st international Consensus Conference

Non PharmacologicalTherapies

for

Alzheimer’s

MadridMay 12th-13th 2005

Hotel Rafael Atocha, Méndez Álvaro, 30

Aimed at:

General Physicians and Specialists, Occupational Therapists, Physiotherapists, Psychologists, Nurses and Nurse Aids, Music-Therapists, Psycho-Motor Therapists, Social Workers, Service Managers and Planners, Gerontologists, and all those interested in Evidence Based Medicine.

Introduction:

The increasing number of aged people among developed and developing countries led dementia to become a prime public health concern.

Fortunately new drugs have not ceased to be released: 1993 Tacrine, 1996 Donepecil, 1998 Rivastigmine, 2001 Galantamine, 2003 Memantine.

Neurobiological or biochemical interventions will certainly be the ones that in future will solve this sad illness.

In the years to come until the illness is overcome, however, we can not leave aside another fundamental question: the care and quality of life of millions of people that precisely due to dementia are, ever more, forced to live institutionalized in nursing homes or day care centres.

The role of Non Pharmacological Therapies (NPT) for these institutionalized or semi-institutionalized people is at least as important as adequate pharmacological intervention.

Sufficient evidence has been provided in the last years to establish the clinically relevant role of cognitive and motor therapies as well as caregiver support among other. Outcomes are better cognition, function, behaviour, and mood, and even delay of institutionalization.

Lately, however, al kinds of “therapies” are mushrooming. As a result of such a variety of proposals patients, the general public and even professionals become confused. This confusionsheds doubt on the clinical value in a variety of ways:

1. There is no consensus about the meaning of the word “Therapy”2. There are no guidelines on interventions (which therapies, for what problem, in what

stage, and what potential adverse effects may be expected)3. The field also lacks methodological research standards to enable efficient comparison

of results.

Internationally leading researchers will try to solve the following problems from the perspective of Evidence Based Medicine:

1. Reach a consensus definition for “Non Pharmacological Therapy” related to AD2. Settle which NPT achieve what outcomes in relation to stage and domain3. Agree on common avenues of research

For the sake of patients and their caregivers all those persons and institutions involved in the project want to contribute to the clinical consolidation of these new treatments.

Ruben Muñiz SchwochertJavier Olazarán Rodríguez

Program

SIMULTA NEOUS TRA NSLATION DURING THE ENTIRE CONFERENCE

Thursday May 12th 200508:30 - 09:00 Registration and documentation

09:00 - 10:30 Welcoming and introductionChair: Barry Reisberg (New York)9:00 - 9:10 Welcoming

09:10 – 09:30 Non Pharma-Therapies and Evidence Based MedicineJordi Peña-Casanova (Barcelona)

09:30-10:00 Biology and Clinical Science of RetrogenesisBarry Reisberg (New York)

10:00-10:30 Description and History of Different NPTRobert Woods (Bangor-Wales)

10:30 - 11:00 INA UGURA TION

11:00 - 11:30 CoffeePress Conference

11:30 - 14:00 FROM PHARMACOLOGICAL TO NON-PHARMACOLOGICAL TREATMENTSChairs: Mercè Boada & Howard Feldman11:30-11:40 Presentation. Howard Feldman (Vancouver)

11:40-12:00 The role of genetics and proteomics in modifying Alzheimer's disease: a foreseeable future? Fernando Valdivieso and Mª Jesús Bullido (Madrid) 12:00-12:20 Immunotherapy and other anti-amyloid strategies: past and future. Alberto Lleó (Madrid) 12:20-12:40 Tau phosphorilation and aggregation as pharmacological targets. Teodoro del Ser (Madrid) 12:40-13:00 Currently approved drugs: differences and complementarities. Ana Frank (Madrid)

13:00-13:20 Clinical trials in mild cognitive impairment and other pre-dementia stages. Howard Feldman (Vancouver)

13:20-13:40 Pharmacological vs non-pharmacological therapies: competition or complement? Mercè Boada (Barcelona)

13:40-14:00 Open discussion and Closure. Howard Feldman (Vancouver)

14:00 - 15:00 Lunch and Poster Session

15:00 - 17:00 CLINICA L RESULTS OF DIFFERENT NON PHARMA THERAPIES IChair: Linda Clare (London)15:00-15:30 NPT from the subjective perspective of the person with dementiaLinda Clare (London)

15:30-16:00 Clinical effects of spouse support programsMary Mittelman (New York)

16:00-16:30 Clinical results of cognitive therapy, reminiscence therapy and reality orientationMartin Orrell & Aimee Spector (London)

16:30-17:00 Clinical results of computer based interventionsLluís Tárraga (Barcelona)

17:00 - 17:30 Coffee

17:30 - 19:00 CLINICA L RESULTS OF NON PHARMA THERAPIES IIChair Linda Teri (Seattle)17:30-18:00 Clinical Results of global stimulationStefanie Auer (Austria)

18:00-18:30 Clinical results of emotional-motor spouse programLinda Teri (Seattle)

18:30-19:00 Benefits of physical exercise for AD patientsMiia Kivipelto (Stockholm)

Friday May 13th 200509:00 - 09:30 ConferenceAntonio Burgueño (Madrid)Relation of NPT, behavioral and psychological symptoms of dementia (BPSD) and physical and pharma restraints.

09:30 - 11:00 ROUND TA BLE II:DEFINING “NON PHARMACOLOGICA L THERAPY”Chair: Robert Woods (Bangor-Wales)

11:00 - 11:30 Coffee

11:30 - 13:15 ROUND TA BLE IIIJavier Olazarán (Madrid), Jordi Peña-Casanova (Barcelona)Overview of Clinical Results of Non Pharmacological Therapies: Working for guidelines.

13:15 - 15:00 Lunch and Poster Session

15:00 - 16:30 CLINICAL RESULTS OF DIFFERENT NON PHARMACOLOGICAL THERAPIES III15:00-15:30 Clinical results of Reminiscence Therapy Claudia Lai (Hong Kong)

15:30-16:00 Intercontinental BPSD variability and Caregiver Support Program in developing countries Cleusa Ferri (London)

16:00-16:30 Longitudinal Donostia Study; Cognitive-Global intervention Cristina Buiza (San Sebastián)

16:30 - 17:30 CONFERENCERuben Muñiz (Madrid)Therapeutic responsiveness and financing care

18:00 - 19:00 Preliminary report of the conferenceBarry Reisberg (New York), Jordi Peña-Casanova (Barcelona), Javier Olazarán (Madrid)

19:00 - 19:20 Closing and awards given for best poster

Scientifici Committee:

Co-Chairmen:Barry Reisberg and Jordi Peña-Casanova

Robert Woods Javier OlazaránHoward Feldman Aimee SpectorMary Mittelman Pablo CoboRuben Muñiz Linda ClareLinda Teri Stefanie AuerMercé Boada Lluís Tárraga

Advisory Committee: Organaizing Committee:

Alfonso Cruz-Jentoft Chairman:Alfredo Robles Rubén MuñizAna Frank JBengt Winblad Javier OlazaránClaudia Lai Jordi Peña-CasanovaCornelia Beck José Carlos BauraDavid Muñoz Marisa Barquero Héctor Maravall Nina MorillasHenry Brodaty Marisa BarqueroMartial van der Linden Nori Graham Orazio ZanettiRafael BlesaJosé Manuel Martínez-LageTeodoro del SerSunnie Kenowsky

Honorary Committee:

Emilio Marmaneu (President CEAFA)Jesús Caldera (Minister of Labour and Social Affaires)Amparo Valcarce (Secretary of State for Social S., Families & Disab.)Ángel Rodríguez (General Director IMSERSO)Margarita Retuerto (Patient´s Ombudsman State of Madrid)

Organized by:

www.NPTherapies.orgConference Organizing Office:Fundación Maria WolffC/Cardenal Silíceo 1428002 Madrid, SpainTel.: + 34 91 413 65 09Fax: + 34 91 515 21 51

Registration Form:Prices:Before April 15th 285 € After April 15th 325 € Registration includes: Attendance to the conference, lunches, coffee breaks, poster sessions

REGISTRATION:You can register as a delegate through the web site (www.nptherapies.org) or sending this registration form by fax to: +34 91 515 21 51

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Notes:

This congress has been organized by:

Sponsor:

With additional support from: