r therapy NITROPRUSSIDE THERAPY: POTENTIAL USE AFTER ACUTE MYOCARDIAL INFARCTION Sodium nitroprusside was given to 5 hypertensive patients with recurrent ischaernic chest discomfort at rest and severe ventricular arrhythmias immediately following acute myocardial infarction. Nitroprusside infusion was started at a rate of 75-125J.Lg/rnl and adjusted to keep the systolic blood pressure between 100 and llOmm Hg.Within 30 minutes of starting nitroprusside, pain decreased, S-T segment elevations diminished, and ventricular arrhythmias disappeared. Signs and sympt()rns returned promptly when nitroprusside was discontinued and again disappeared when the infusion was reinstituted. Although a preliminary study, the results suggest nitroprusside may have a potentially important role in treating other postinfarction patients with similar conditions. Mukherjee, D. et al.: Journal of the American Medical Association 235: 2406 (31 May 1976) I NPHARMA 19th June, 1976 p7

NITROPRUSSIDE THERAPY: POTENTIAL USE AFTER ACUTE MYOCARDIAL INFARCTION

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NITROPRUSSIDE THERAPY: POTENTIAL USE AFTER ACUTE MYOCARDIAL INFARCTION

Sodium nitroprusside was given to 5 hypertensive patients with recurrent ischaernic chest discomfort at rest and severe ventricular arrhythmias immediately following acute myocardial infarction. Nitroprusside infusion was started at a rate of 75-125J.Lg/rnl and adjusted to keep the systolic blood pressure between 100 and llOmm Hg.Within 30 minutes of starting nitroprusside, pain decreased, S-T segment elevations diminished, and ventricular arrhythmias disappeared. Signs and sympt()rns returned promptly when nitroprusside was discontinued and again disappeared when the infusion was reinstituted. Although a preliminary study, the results suggest nitroprusside may have a potentially important role in treating other postinfarction patients with similar conditions. Mukherjee, D. et al.: Journal of the American Medical Association 235: 2406 (31 May 1976)

I NPHARMA 19th June, 1976 p7