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Nitric Oxide (Nitrogen monoxide) Endothelial Relaxing Factor (EDRF). *組員 B9902080 廖佩炫 B9902095 盧翰生. How nitric oxide is produced?. L-arginine + 3/2 NADPH + H + + 2 O 2 citrulline + nitric oxide + 3/2 NADP +. How nitric oxide is produced?. 1.Unrelated to body. - PowerPoint PPT Presentation
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How nitric oxide is produced? L-arginine + 3/2 NADPH + H+ + 2 O2
citrulline + nitric oxide + 3/2 NADP+
How nitric oxide is produced?
• Reduction of inorganic nitrate
• By Nitroglycerin and amyl nitrite
• Nitric oxide is generated by phagocytes
• Nitric oxide is released by neurons
1.Unrelated to body
2.related to body
Effects of nitric oxide to the human body; Vasodilation.(Penile Erection)
Mechanisms of NO Action NO is formed
diffuses into the blood
diffuses into the muscle cells
activates guanylyl cyclase
dephosphorylation of GTP
signalling smooth muscle relaxation
Effects of nitric oxide to the human body; Neurotransmission
Modifying electrical activity of neurons
How is carbon monoxide produced• Generated by the enzyme heme oxygenase
(HO) (where it is found in the neurons in the brain or PNS ) - first example
• Vertebrate body produces small amount of CO
• During heme metabolism
Effects of Carbon monoxide Vasodilation Carbon Monoxide produced
activation of calcium-activated potassium channels
inducing hyperpolarizing outward currents called STOCs
smooth muscle hyper-polarization
Vasodilation
參考資料http://www.google.com.tw/images?um=1&hl=zh-TW&biw=1076&bih=412&tbs=isch%3A1&sa=1&q=MUSCLE+CELL&aq=f&aqi=g1&aql=&oq=http://en.wikipedia.org/wiki/Carbon_monoxidehttp://en.wikipedia.org/wiki/Hemehttp://nitricoxidewarning.com/nitric-oxide-supplements-find-the-best-nitric-oxide-supplement/http://www.bewellbuzz.com/general/amazing-benefits-nitric-oxide/http://blog.udn.com/jnwu/3958716http://www.forcefactorsuccess.com/best-nitric-oxide-supplementshttp://www.phagocytes.net/groups/erwig.htmlhttp://www.boatingsidekicks.com/cobro/cobrochure.htmhttp://www.cdc.gov/co/faqs.htmhttp://www.sigmaaldrich.com/life-science/metabolomics/enzyme-explorer/learning-center/plasma-blood-protein/hemoglobin-heme-products.htmlhttp://psychology.kenyon.edu/psy_111/week5.htmhttp://jap.physiology.org/content/100/3/1065.fullhttp://jap.physiology.org/content/100/3/1065/F1.expansion.htmlhttp://ajrccm.atsjournals.org/cgi/content/full/171/4/354http://en.wikipedia.org/wiki/Myosin_light_chain_phosphatase