NIH RoadmapandChemoinformatics

Jeffery LooNLM Associate Fellow

Welch Library Journal Club2004/12/7

Discussion

Science research developments(NIH Roadmap)

Opportunities for information professionals(Chemoinformatics)

Agenda

Summarize 2 articles

Discussion

Demonstration

NIH Roadmap definition

new research vision

accelerate discovery and knowledge application

priorities

Who is Dr. Elias Zerhouni?

Motivations for the NIH Roadmap

NIH is not responding fast enough to scientific developments

Address critical scientific gaps

Respond to converging nature of research

Complex nature of disease

Genes

Behavior

Diet/Nutrition

Infectious agents

Environment

Society

???

Briefly name the 3 Roadmap themes.

New pathways to discovery

Research teams of the future

Re-engineering the clinical research team

New Pathways to Discovery

understand complex biological systems

understand their connections

build better "toolbox" for researchers

Research Teams of the Future

combining skills and disciplines

expertise of nontraditional teams

high-risk research

interdisciplinary research

public-private partnerships

Reengineering the Clinical Research Enterprise

Streamline clinical research:

Integrated networks and teams • partnerships, IT, standards, information storage

informatics infrastructure • (NECTAR)

NIH Roadmap summary

Interdisciplinary projects focusing on:clinical research

structural biology informatics

Role of biomedical information in the spectrum of medical research:

– bench research– technology and knowledge transfer– clinical trials

Criticisms?

Chemoinformatics

IT for managing chemical information and solving chemical problems

= chemistry + information science + computer science

Driven by drug discovery research

Drug discovery

Chemical + biological system desired response?

Combinatorial chemistry

• synthesizing large numbers of related chemical compounds

• can help design drug leads

• information rich– physiology of the biological effect– starting material properties– synthesis protocols

High throughput screening

Chemoinformatics tasks

Manage information about:

Chemical properties

Chemical synthesis

Biological effects

PubChem