ResistanceMovement:Drugs,bugsandthefightagainst

über-germs

Tuesday,March28,20176:00–7:30p.m.

TheJosephB.MartinConferenceCenter

TheNewResearchBuildingHarvardMedicalSchool77AvenueLouisPasteur

Boston,MA02115

ResistanceMovement:Drugsbugsandthefightagainstüber-germs

BillHanage,PhDAssociateProfessorofEpidemiologyHarvardMedicalSchoolMahaFarhat,MD,CMAssistantProfessorofBiomedicalInformaticsHarvardMedicalSchoolAssistantPulmonaryandCriticalCarePhysicianMassachusettsGeneralHospitalJamesKirby,MDAssociateProfessorofPathologyHarvardMedicalSchoolMedicalDirector,ClinicalMicrobiologyBethIsraelDeaconessMedicalCenterMichaelGilmore,PhDSirWilliamOslerProfessorofOphthalmologyHarvardMedicalSchoolMassachusettsEye&Ear

AbouttheSpeakers:

BillHanage,PhDBillHanageisAssociateProfessorofEpidemiologyattheHarvardUniversityT.H.ChanSchoolofPublicHealthandafacultymemberintheCenterforCommunicableDiseaseDynamics.Heresearchestheepidemiologyandevolutionofinfectiousdiseases,usinggeneticstotracetheemergenceandspreadofdangerouspathogenscausingpneumonia,meningitisanddrugresistantinfections.Hehaswrittenover100articlesandbookchaptersonthesesubjectsandhaswontheFlemingPrizeforhisresearch,namedforthediscovererofPenicillin,AlexanderFleming.

MahaFarhat,MDMahaFarhatholdsanMDfromtheMcGillUniversityFacultyofMedicineandaMScinbiostatisticsfromtheHarvardChanSchoolofPublicHealth.SheisalsoapracticingphysicianattheMassachusettsGeneralHospitalDivisionofPulmonaryandCriticalCareMedicine.Dr.Farhat'sresearchfocusesonthedevelopmentandapplicationofmethodsforassociatinggenotypeandphenotypeininfectiousdiseasepathogens,withastrongemphasisontranslationtobetterdiagnosticsandsurveillanceinresource-poorsettings.Todate,Farhat'sworkhasfocusedonthepathogenMycobacteriumtuberculosisandspansthespectrumfromcomputationalanalysistofieldstudies.SheisPIandCo-InvestigatoronseverallargeprojectsfundedbyNIHincludingtheNIAIDandtheBD2Kinitiative.JamesKirby,MDJamesKirbyisanAssociateProfessorofPathologyatHarvardMedicalSchoolandtheMedicalDirectoroftheClinicalMicrobiologyLaboratoryatBethIsraelDeaconessMedicalCenter.Dr.Kirby'scurrentinterestsinhisNationalInstitutesofHealth-fundedresearchlaboratoryincludedevelopingnovelantimicrobials,understandinghowbacterialpathogenscausedisease,anduseofinkjetprintingtechnologytoidentifymultidrug-resistantpathogensmorequickly.HeiscurrentlyontheeditorialboardsoftheJournalofClinicalMicrobiology,andAppliedandEnvironmentalMicrobiology,andwasformerPresidentoftheNortheastBranchoftheAmericanSocietyofMicrobiology.HealsoservesontheHarvardCommitteeonMicrobiologicalSafety(COMS).Moreinformationabouthisresearchlaboratorymaybefoundathttp://www.kirbylab.org.

MichaelGilmore,PhDMichaelS.Gilmore,PhDiscurrentlytheSirWilliamOslerProfessorofOphthalmology,andMicrobiologyandImmunobiologyatHarvardMedicalSchool.HeservesonthesteeringcommitteesoftheHarvardMicrobialSciencesInitiative,andtheInfectiousDiseaseInitiativeoftheBroadInstituteofMITandHarvard.AsPrincipalInvestigatoroftheHarvard-wideProgramonAntibioticResistance,hisresearchfocusesontheevolutionanddevelopmentofmultidrugresistantstrainsofenterococci,staphylococci,andstreptococci,andthedevelopmentofnewtherapeuticapproaches.HeisfounderandorganizeroftheinternationalASMConferenceonEnterococciseries,EditorinChiefofthepublicaccessbook,Enterococci:FromCommensalstoLeadingCausesofDrugResistantInfection.Gilmorecontinuestoserveonnumerousadvisoryboardsandcommitteesforpublicandprivateorganizations,mainlyfocusedondrugdiscovery,antibioticresistance,andbacterialpathogenesis.

ResistanceMovement:Drugsbugsandthefightagainstüber-germs

With many bacteria becoming impervious to drugs, new approaches are needed to combat the rise ofantibiotic resistance. In this seminar, Harvard scientists and clinicians will discuss the history of drugresistance, how bacteria become able to shrug off the medications we use to treat disease, and ways toaddressthecrisis.ArticlesThedrug-resistantbacteriathatposethegreatesthealththreatsCassandraWillyard,Naturenature.com/news/the-drug-resistant-bacteria-that-pose-the-greatest-health-threats-1.21550SimpleMethodQuicklyTestsHard-to-TreatBacteria’sSusceptibilitytoDifferentAntibioticsJacquelineMitchell,BethIsraelDeaconessNewsbidmc.org/News/PRLandingPage/2016/July/Kirby-Antibiotics.aspx

Drug-resistant‘nightmarebacteria’showworrisomeabilitytodiversifyandspreadKarenFeldscher,HarvardT.H.ChanNewshsph.harvard.edu/news/press-releases/drug-resistant-nightmare-bacteria-diversify-spread/

Superbug:AnEpidemicBeginsKatherineXueharvardmagazine.com/2014/05/superbug

VideoEpidemiologistBillHanageTavisSmiley,WGBHpbs.org/wnet/tavissmiley/interviews/associate-professor-bill-hanage/

Plaguesandpopulations--patternsofpathogenevolution.MicrobiologySocietyhttps://www.youtube.com/watch?v=gwl61-jcyroTB'sSurprisingFamilyTreeHarvardMedicalSchoolhttps://hms.harvard.edu/news/global-health/tbs-surprising-family-tree-9-1-13