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New Investigator (NI) Has not been PI on a significant NIH research grant (R01) Can have obtained small research grants (e.g., R03, R21), previous

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Page 1: New Investigator (NI)  Has not been PI on a significant NIH research grant (R01)  Can have obtained small research grants (e.g., R03, R21), previous
Page 2: New Investigator (NI)  Has not been PI on a significant NIH research grant (R01)  Can have obtained small research grants (e.g., R03, R21), previous

New Investigator (NI) Has not been PI on a significant NIH research grant (R01)

Can have obtained small research grants (e.g., R03, R21), previous K or F grants, or been on T32

Early Stage Investigator (ESI)A new investigator within 10 years of doctorate or completing residency

Status of NI or ESI defined in your eRA Commons profile & check with RMG at Stanford

http://grants1.nih.gov/grants/new_investigators/index.htm

Page 3: New Investigator (NI)  Has not been PI on a significant NIH research grant (R01)  Can have obtained small research grants (e.g., R03, R21), previous
Page 4: New Investigator (NI)  Has not been PI on a significant NIH research grant (R01)  Can have obtained small research grants (e.g., R03, R21), previous

National Research Service Awards (NRSAs)

Training Grants (T32, 34, 35, 90)

Fellowship Grants (F30-33 series) for early training

US Citizen, Non-Citizen National, or lawfully admitted for

Permanent Residence

Must have a PhD or MD or comparable doctoral degree from an

accredited domestic or foreign institution

Page 5: New Investigator (NI)  Has not been PI on a significant NIH research grant (R01)  Can have obtained small research grants (e.g., R03, R21), previous

Program Description

F30Predoctoral FellowshipCombined MD/PhD and other dual-doctoral degree training.

F31

Predoctoral FellowshipDissertation research and training in scientific health-related fields relevant to the missions of the participating NIH Institutes and Centers.

F32

Individual PostdoctoralFor individuals to broaden their scientific background and extend their potential for research in specified health-related areas.

F33

NRSA for Senior FellowsTo support experienced scientists who wish to make major changes in the direction of their research careers or who wish to broaden their scientific background by acquiring new research capabilities as independent investigators.

F32s are mostly unsolicited

http://grants.nih.gov/training/f_files_nrsa.htm

Page 6: New Investigator (NI)  Has not been PI on a significant NIH research grant (R01)  Can have obtained small research grants (e.g., R03, R21), previous

F32 SectionPage Limit

Specific Aims 1

Research Strategy 6

Respective Contributions 1

Selection of Sponsor and Institution 1

RCR 1

Goals for Fellowship Training and Career 1

Activities Planned Under This Award 1

Doctoral Dissertation and Other Research Experience 2

Sponsor and Co-Sponsor 6

Biographical Sketch 4

Page 7: New Investigator (NI)  Has not been PI on a significant NIH research grant (R01)  Can have obtained small research grants (e.g., R03, R21), previous

F32s are training awards, not research awards

Major review considerations are your:

potential for a productive career

need for the proposed training

the degree to which the research training proposal, the sponsor, and the environment will satisfy those needs and develop the career

Page 8: New Investigator (NI)  Has not been PI on a significant NIH research grant (R01)  Can have obtained small research grants (e.g., R03, R21), previous

http://grants.nih.gov/training/f_files_nrsa.htm

Page 9: New Investigator (NI)  Has not been PI on a significant NIH research grant (R01)  Can have obtained small research grants (e.g., R03, R21), previous
Page 10: New Investigator (NI)  Has not been PI on a significant NIH research grant (R01)  Can have obtained small research grants (e.g., R03, R21), previous

http://grants.nih.gov/training/careerdevelopmentawards.htm

Page 11: New Investigator (NI)  Has not been PI on a significant NIH research grant (R01)  Can have obtained small research grants (e.g., R03, R21), previous
Page 12: New Investigator (NI)  Has not been PI on a significant NIH research grant (R01)  Can have obtained small research grants (e.g., R03, R21), previous

US Citizens, Non-Citizen Nationals, Permanent Residents (except K99/R00); not renewable (except K24)

Must devote a minimum of 75% effort to research and career development activities

3-5 years of support

Principal Investigators on R03 or R21 are eligible to apply (except K99/R00)

Principal Investigators on R01 or subproject Principal Investigators on a P01 are not eligible to apply

Page 13: New Investigator (NI)  Has not been PI on a significant NIH research grant (R01)  Can have obtained small research grants (e.g., R03, R21), previous

Program Description

K01 Mentored Research Scientist Development AwardCareer development in a new area of research

K08 Mentored Clinical Scientist Research Development AwardCareer development for those with clinical doctoral degree in biomedical/behavioral research, including translational research—if patient research, see K23.

K07 Academic Career AwardDevelopmental of junior candidates; leadership for individuals in improving curricula and enhancing research capacity.

K22 Career Transition Award—Research or Clinical ScientistSupport to an individual postdoctoral fellow in transition to a faculty position.

K23 Mentored Patient-Oriented Research Career Development AwardDevelopment of the independent research scientist for patient research—if not patient-oriented research in biomedical area, see K08.

K25 Mentored Quantitative Research Career Development AwardTo foster interdisciplinary collaboration in biomedical research by supporting career development experiences for scientists with quantitative and engineering backgrounds.

K99/R00 NIH Pathway to Independence Award. Provides 5 years’ support in 2 phases:I.1-2 years of mentored support for highly promising postdoctoral fellows.II.Up to 3 years of independent support contingent on securing an independent research position.

Page 14: New Investigator (NI)  Has not been PI on a significant NIH research grant (R01)  Can have obtained small research grants (e.g., R03, R21), previous

Program Description

K22 Career Transition AwardSupport to an individual postdoctoral fellow in transition to a faculty position.

K99/R00 NIH Pathway to Independence Award. Provides 5 years’ support in 2 phases:

I.1-2 years of mentored support for highly promising postdoctoral fellowsII.Up to 3 years of independent support contingent on securing an independent research position.

Page 15: New Investigator (NI)  Has not been PI on a significant NIH research grant (R01)  Can have obtained small research grants (e.g., R03, R21), previous

K99: Mentored research experience for up to 2 years

R00: Transition to research independence as junior faculty for up to 3 years

Applicants: no more than 5 years of postdoctoral research training at the time of initial application or resubmission

Non-US citizens may apply, but institution must be domestic

Transition to R00 phase requires offer and acceptance of tenure-track, full-time assistant professor position (or equivalent)

15

Page 16: New Investigator (NI)  Has not been PI on a significant NIH research grant (R01)  Can have obtained small research grants (e.g., R03, R21), previous

16

K ContentsSection Material Requested

Candidate Information & Career Development Plan

Candidate backgroundCareer Goals and ObjectivesCareer Development & Training ActivitiesTraining in Responsible Conduct of Research

Research Plan Specific Aims + Research Strategy

Statements of Support Statements by Mentor, Co-Mentor, Consultants

Environment and Institutional Commitment to Candidate

Description of Institutional Environment

Institutional Commitment to Candidates Research Career Development

Letters of Reference

3-5 reference letters not from the Mentor/Co-Mentor

From established scientists (referees) that address candidate’s qualifications, training, interests and potential for becoming an independent scientist

12 pg

Page 17: New Investigator (NI)  Has not been PI on a significant NIH research grant (R01)  Can have obtained small research grants (e.g., R03, R21), previous

Candidate

Mentor/ConsultantsEnvironment/Institution

Research StrategyCareer Development Plan

Page 18: New Investigator (NI)  Has not been PI on a significant NIH research grant (R01)  Can have obtained small research grants (e.g., R03, R21), previous

Postdoc orResidency

Grad orMed School

Predoc Predoc

T32 T32

NRSA NRSA

Postdoc Postdoc

F32 F32

Ment Ment Research Research

K01K01

Pathway to Pathway to Independence Independence

(K99/R00)(K99/R00)

IndependeIndependent Scientist nt Scientist

K02K02

Midcareer Midcareer Patient-Patient-Oriented Oriented

K24 K24

Early Middle Senior

Postdoc Postdoc

T32T32

Senior Senior Scientist Scientist

Award K05Award K05Ment Clinical Ment Clinical K08K08

Ment Ment Patient-Patient-

Orient K23Orient K23Ment Quant Ment Quant RCDA K25 RCDA K25

NRSA NRSA

Predoc Predoc

F30, F31F30, F31 Small Research Grant R03Small Research Grant R03

Exploratory/Development Grant R21Exploratory/Development Grant R21

Research Project Grant R01Research Project Grant R01

U-Series Cooperative GrantsU-Series Cooperative Grants

SBIR, STTR R41/R42SBIR, STTR R41/R42

P-Series Program Project/CenterP-Series Program Project/Center

Career Transition Career Transition Award Award K22K22

NRSA NRSA Senior Senior

Fellow Fellow F33F33

Page 19: New Investigator (NI)  Has not been PI on a significant NIH research grant (R01)  Can have obtained small research grants (e.g., R03, R21), previous

Grant F32 K01 K99 R01

NCI 18% 55% 17% 14%

NIAID 19.6% 58% 18% 19%

NHLBI 21% 17% 30% 14.8%

Page 20: New Investigator (NI)  Has not been PI on a significant NIH research grant (R01)  Can have obtained small research grants (e.g., R03, R21), previous

A valuable tool to access any F or K grant

Demonstration

Page 21: New Investigator (NI)  Has not been PI on a significant NIH research grant (R01)  Can have obtained small research grants (e.g., R03, R21), previous