Breakthrough Technology

To Help Maintain Catheter Patency

That Reduces Reflux

Needlefree Catheter Patency Device

The first and only FDA-cleared device shown to

significantly reduce all types of reflux into a catheter and

feature ICU Medical’s proven infection control technology.

Neutron®

Maintaining catheter patency and minimizing occlusions can be important steps in your efforts to enhance patient safety, improve patient outcomes, and reduce costs.

But despite your efforts, central line occlusions, which are frequently caused by blood reflux,1

remain a significant issue that can result in delays in critical patient care, increased risk of

infection, and increased healthcare costs. That’s why reducing the risk of catheter occlusions

may help you decrease the need for expensive declotting agents such as t-PA, and reduce the

clinical costs associated with managing catheter occlusions.

Neutron’s breakthrough anti-reflux technology helps you stop occlusions before they start, while providing a safe and effective microbial barrier.

Unlike other technologies, such as positive displacement needlefree connectors, Neutron is the

only device FDA-cleared to prevent all forms of reflux into a catheter and utilize ICU Medical’s

patented needlefree connector technology which has been proven to minimize contamination

and help you lower the risk of catheter related bloodstream infections (CRBSI).2,3,4

The Neutron Catheter Patency Device Reduces Reflux to Help You

Minimize Occlusions

Neutron May Help You Reduce Catheter Occlusions by

50%5

Reducing catheter occlusions with the Neutron catheter patency device may provide real-time clinical benefits.

Avoid Delays in Critical Patient Care

Neutron may help avoid delays in therapy  of critical intravenous medications  (e.g.,

antibiotics and oncolytics), nutritional support, and blood products.

Avoid Patient Discomfort and Pain

Neutron may help avoid patient discomfort and pain caused by

unnecessary needlesticks, catheter restarts, and manipulating the IV site.

Avoid Unnecessary Costs

Neutron may help minimize unnecessary costs that add up

when treating an occlusion.

Help Reduce Risk of Infection

Neutron may help reduce the risk of infection by preventing thrombosis

and minimizing IV line manipulation.

Designed to Prevent All Known Causes of Reflux into a Catheter

Reflux of blood into the catheter has been shown to contribute to biofilm formation and catheter occlusion.

Internal Causes > Patient Vascular Pressure

Changes Caused by:

> Coughing

> Sneezing

> Movement

> Crying

External Causes > Connection and Disconnection

of a Luer

> IV Bag Running Dry or an Infusion Pump Stopping

> Syringe Plunger Rebound

Reflux

Superior Anti-Reflux Technology

Because of an innovative design that incorporates

a patented bi-directional silicone valve and bellows

feature to help prevent reflux at all times, Neutron helps

maintain catheter patency during times when traditional

connectors have been shown to occlude most often.

Unlike other  anti-reflux  valves, Neutron’s

patented technology provides the unique ability

to absorb and physically compensate for pressure

variations that typically result in blood reflux into a catheter.

Valve During Infusion

Valve During Aspiration

Valve With No Fluid Flow

Valve During Reflux Challenge

Clear housingpermits visual confirmation of flush after use with medications or blood.

Straight fluid pathfor clearing blood and blood residual with low flush volumes.10

Minimal residual volume (also referred to as priming volume) allows for lower flush volumes.

Split-septuma preferred design feature for connectors.9

Silicone Seal and Internal CannulaSpecifically designed to minimize contact between the

connector’s external surface and the internal fluid path upon luer activation, this proven Clave® technology

minimizes entry points for bacteria. Several studies have attributed this feature to a significant reduction in bacterial

contaminants passed through the connector. 6,7,8

Market-leading Infection Control Technology Proven to Minimize Bacterial Contamination2,3,4,6,7,8

Neutron can help your efforts to reduce bloodstream infections by minimizing entry points for bacteria and maximizing the effectiveness of every flush.

Add a Splash of ColorFor Quick and Easy Line Identification.Customize Neutron with a variety of color-coded rings to help you improve IV line

management and avoid medication mix-ups.

Color-coded needlefree IV connector rings designed to help you:

> Increase patient safety and reduce the possibility of medication errors

> Quickly access the proper infusion port in emergency situations

> Improve connector change interval compliance with better needlefree connector identification

©2014 ICU Medical Inc. | M1-1307 Rev.06 800.824.7890 | www.icumed.com

1 Gorski, Lisa A MS, RN, CS, CRNI. Central Venous Access Device Occlusions: Part 1: Thrombotic Causes and Treatment. Home Healthcare Nurse. 21:2 115-121, February 2003. 2 Ryder M, James G, Pulchini E, Bickle L, Parker A. Differences in bacterial transfer and fluid path colonization through needlefree connector-catheter systems in vitro. Presented at the Infusion Nursing Society Meeting, May 2011. 3

Moore C, RN, MBA, CIC. Maintained Low Rate of Catheter-Related Bloodstream Infections (CR-BSIs) After Discontinuation of a Luer Access Device (LAD) at an Academic Medical Center. Poster presented at the annual Association for Professionals in Infection Control and Epidemiology (APIC) Conference 2010, Abstract 4-028. 4 Evaluation of the Clave® technology and resistance to microbial ingress. Report of a study commissioned by ICU and conducted by Nelson Laboratories, 2008. M1-1212 rev. 03. 5 ICU Medical Study Summary. Observational In-Vivo Evaluation of the Neutron™ Needlefree Catheter Patency Device and its Effects on Catheter Occlusions in a Home Care Setting, 2011. 6 Yebenes J, Delgado M, Sauca G, Serra-Prat M, Solsona M, Almirall J, et al. Efficacy of three different valve systems of needlefree closed connectors in avoiding access of microorganisms to endovascular catheters after incorrect handling. Crit Care Med 2008;36: 2558–2561. 7 JD Brown, HA Moss, TSJ Elliott. The potential for catheter microbial contamination from a needleless connector. J Hosp Infect. 1997.; 36:181-189. 8 Ryder M, RN, PhD. Bacterial transfer through needlefree connectors: Comparison of nine different devices. Poster presented at the Annual Society for Healthcare Epidemiology of America (SHEA) conference 2007. 9 Guideline for the Prevention of Intravascular Catheter-Related Bloodstream Infections, Final Issue Review, May 17, 2010. 10 Data on file at ICU Medical. Low Volume Flush Characteristics of Unique Needlefree Connectors M1-1223 Rev. 1.

To learn how to put Neutron to work for you, contact us today by calling 800.824.7890 or by visiting icumed.com/neutron.

Neutron’s saline flush option allows you to reduce risks, cost, and time associated

with Heparin use.

Technical SpecificationsResidual Volume 0.1 mL

Flow Rate at Gravity 100 mL/minute

Blood Compatibility Yes

MRI Compatibility Yes

High Pressure Compatibility 10 mL/second

Drug CompatibilityAlcohol Yes

Lipids Yes

Chlorhexidine Yes

Chemotherapy Yes