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8/3/2019 NeuroRegeneration Conference Public
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Hope For The Healing BrainRestoring Your Brains Chemical Communication
Jeremy E. Kaslow, M.D.Santa Ana, California
www.drkaslow.comJanuary 21, 2012
THE ACADEMY OF
COMPREHENSIVE INTEGRATIVE MEDICINE
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Root Causes of Disease
Only by understanding the wisdom ofthe body shall we attain that mastery
of disease and pain which shall enableus to relieve the burden of mankind.
William Harvey, M.D.
January 2012 Jeremy E. Kaslow, MD 3
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Root Causes of Disease
Genetics
Toxicity
Psychological/Emotional Imprints
Infections*
Structure Nutrition
January 2012 Jeremy E. Kaslow, MD 4
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PATHWAYS
Metabolic
Neuromuscular
Immunologic
Infections*
Inflammation
Endocrine
Psychological
ROOT CAUSES
Genetics
Toxicity
Psychoemotional
Infections*Structure
Nutrition
NeuroDegeneration
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Avoidance
StructureDetoxification
Nutrition
January 2012 Jeremy E. Kaslow, MD 6
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Brain Health vs. Brain Aging
Primary regulator of overall health is brain /CNS
health. Your body cannot function optimally if
the master controller, your brain is not
functioning optimally.
Brain /CNS health depends on:
1. The number and function of CNS cells (100 billion
neurons and 1000 billions glial cells)2. Neurotransmitter balance to deliver signals between
neurons in the brain, nervous system and other cells.
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Brain /CNS Cellular Health
Hallmarks of neurodegeneration:1. Mitochondrial dysfunction
2. Oxidative Stress
3. Neuroinflammation Several PPAR agonists are possible therapeutic
agents for neurodegenerative disorders becausethey have been shown to protect against:1. Mitochondrial dysfunction
2. Oxidative damage
3. Inflammation
4. Apoptosis (programmed cell death)
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Peroxisome Proliferator-Activated Receptors
(PPARS)
PPARS are factors that bind directly to DNA andregulate gene expression
Initially, it was thought that PPARs activity was
limited to lipid metabolism and glucosehomeostasis, but PPAR- is also expressed inbrain neurons and astrocytes
Several studies demonstrated PPAR- agonists
improve disease-related symptoms andpathology in animals by directly improvingmitochondrial function and ATP production
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PPARS ligands
Fatty acids and their derivatives are the main
natural ligands of all PPARs: palmitic, oleic,
linolenic, linoleic, and arachidonic acid
Synthetic ligands include the glitazones,
tyrosine-based agonists, and non-steroidal
anti-inflammatory drugs (fenoprofen,
ibuprofen, and indomethacin), and fibrates
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PPARS agonists/activators
Soy isoflavones genistein, daidzein, biochanin A,formononetin, and glycitein
Red Clover metabolites equol, ODMA, 6-hydroxydaidzein,3-hydroxygenistein, 6-hydroxy-ODMA, dihydrogenistein,
and dihydrodaidzein Turmeric (curcumin)
Cinnamon
Amino Acids (glutamine, arginine)
green tea (catechin, epigallocatechin-3-gallate)
Grape and blueberry phytochemicals (pterostilbene)
Lipoic acid
Acetyl-l-carnitine
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Neurotransmitters
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Multiple Pathways
January 2012 Jeremy E. Kaslow, MD 13
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Neurotransmitter Associations
Dopamine functions in the brain include roles in:
behavior and cognition
voluntary movement
motivation
punishment and reward
inhibition of prolactin production (involved in lactation and sexual gratification) mood
attention
working memory
learning
Dopamine Insufficiency: Loss of control/addictions/cravings of any type
Obesity
Parkinsons Disease
Restless Leg Syndrome
January 2012 Jeremy E. Kaslow, MD 14
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Neurotransmitter Associations
Serotonin Insufficiency:
Sleep disorders
Sugar cravings
Eating disorders (bulimia/anorexia)
Sexual Addiction
January 2012 Jeremy E. Kaslow, MD 15
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Neurotransmitter Associations
Acetylcholine Insufficiency:
Dehydration (Ach controls moisture levels)
Arthritis
Osteoporosis
Multiple Sclerosis
January 2012 Jeremy E. Kaslow, MD 16
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Memory & Neurotransmitters
Acetylcholine access memory
speed and immediate memory
Dopamine working memory
Serotonin visual memory and perception
GABA organization of memory
January 2012 Jeremy E. Kaslow, MD 17