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Syllabus Neuroepidemiology Feature Considerations Instructor & TA Information (for each Faculty and TA) Myriam Fornage, PhD (Primary) Jan Bressler, PhD [email protected] [email protected] Tel(MF): 713-500-2463 (assistant: Sonia Davies, 713-500-2402) Tel(JB): 713-500-9919 Institute of Molecular Medicine; Sarofim Research Building Room 530.G (MF) SPH RAS E503 (JB) Instructors available by appointment. Please contact Dr. Fornage or Dr. Bressler by e- mail or by phone Course Description Neuroepidemiology PH2998 Fall 2 credit hrs Format:___ITV___Online_X__Face-to- face___Hybrid Revised February, 2011

Nepi Syllabus

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Syllabus NeuroepidemiologyFeatureConsiderations

Instructor & TA Information

(for each Faculty and TA) Myriam Fornage, PhD (Primary) Jan Bressler, PhD

[email protected] [email protected]

Tel(MF): 713-500-2463 (assistant: Sonia Davies, 713-500-2402) Tel(JB): 713-500-9919

Institute of Molecular Medicine; Sarofim Research Building Room 530.G (MF)

SPH RAS E503 (JB)

Instructors available by appointment. Please contact Dr. Fornage or Dr. Bressler by e-mail or by phone

Course Description Neuroepidemiology PH2998

Fall

2 credit hrs

Format:___ITV___Online_X__Face-to-face___Hybrid

The purpose of this course is to provide an overview of the risk factors for a variety of neurologic and neuropsychiatric diseases, including stroke, Alzheimers disease and other dementias, Parkinsons Disease, mental retardation, autism, and affective disorders. Areas covered in this course include a description of the prevalence, incidence, mortality, risk factors, and etiologic mechanisms.

Students will gain an understanding of the impact of these diseases on public health; of the unique methodological issues associated with epidemiologic and genetic studies of these diseases; and of the basic pathobiology and clinical aspects of these disorders.

The course aims to aid students comprehension of published literature in neuroepidemiology and neurogenetics.

The course will cover the specific area of epidemiology of common brain diseases.

Textbook

and Materials Neuroepidemiology : From Principles to Practice (Nelson et al, eds; ISBN 0-19-513379-X) will be on reserve in the library as reference material

A copy of lectures slides will be provided at session and/or will be made available on Blackboard

Reading material will be provided prior to lecture on Blackboard

Course Expectations

Students are expected to complete an oral presentation describing a specific research paper (journal club format). They will critically evaluate study rationale/ hypothesis, design, analysis, and interpretation. Students are expected to complete a final essay paper describing the pathophysiology, epidemiology, genetics, prevention and treatment of a selected neurological disease and to discuss examples of research challenges and gap in knowledge pertaining to the disease.

Course Learning Objectives

Identify the unique methodological problems associated with the study of the epidemiology and genetic epidemiology of these diseases.

Describe the prevalence, incidence, mortality, risk factors, and etiologic mechanisms.

Describe the impact of neurologic diseases on public health

Describe the methodologies to identify genes influencing neurological diseases

Describe basic pathophysiology and clinical aspects (symptomatology, diagnosis, and treatment) of major neurologic diseases

List of Topics

The class will address the epidemiology and genetics of major neurological diseases. General topics will include: Primer of brain biology; epidemiologic methods in neurology; clinical trials in neurology; genetic epidemiology of neurological disease. Specific disease topics will include: stroke, brain aging, Alzheimer's disease, Parkinson's disease, epilepsy, schizophrenia and affective disorders, brain aneurysms, autism

Learning Activities

Student will learn to critically appraise published literature in neuroepidemiology and neurogenetics by presenting selected papers for issues related to study rationale/ hypothesis, design, analysis, and interpretation

Student Assessment

And Grading Criteria Letter grade (A,B,C,F or I) based on class attendance (20(20%); reading assignments with short quizzes (20%); a student's presentation (30%); and a final take-home examination (30%). Final grades will be assigned as follow: A(90); B(80); C(70); F( 10 min.) are not permitted.

Academic Dishonesty

Current school policy applies. See http://www.sph.uth.tmc.edu/uploadedfiles/catalog.pdf Evidence of academic dishonesty will result in grade F

It is assumed that, for group activities, all students will contribute to the assignment and will not take credit for work accomplished by others.

E-mail Procedures and online etiquette:

Include course number in subject line for all e-mail correspondence Use of online material in presentations and papers must be appropriately referenced.

Course Calendar

SEPARATE DOCUMENT DO NOT SUBMIT COURSE CALENDAR TO STUDENT AFFAIRS.

Separate document

Create a separate document for the course calendar, which will allow students to print it.

For help with learning objectives, see http://www.sph.uth.tmc.edu/oid/default.aspx?id=9224Revised February, 2011