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National Conference on Drug Discovery and Formulation Development 23rd February 2016
Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus
National Conference on Drug Discovery and Formulation Development 23rd February 2016
Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus
Chairman
Amity University, Lucknow Campus
Chancellor
Amity University Rajasthan
Amity University Haryana
Dr. Aseem Chauhan President
Amity University Mumbai
It gives me immense pleasure and sense of great pride that Amity Institute of Pharmacy,
Amity University, Uttar Pradesh, Lucknow Campus, is organizing a National Conference on
Drug Discovery & Formulation Development on February 23, 2016.
The National Conference is a step towards discussion and deliberation in sharing
knowledge on innovation and emerging areas in Drug Discovery and related fields. I am sure that
the presence of scientists and researchers from various leading centers of Pharmaceutical Science
in India will lead to a wonderful opportunity to exchange thoughts and ideas on contemporary
issues and will set new goals and targets for young researchers and scientists in the area of Drug
Discovery.
As an obligation towards our society, we must also contemplate how this research can be
applied and commercialized so that India can not only become a front runner in the field of New
Drug Discovery and Formulation Development but also become self-sufficient in the area of
health and medicine.
I wish organizers as well as the participants of this prestigious National Conference, a
great success and hope that ideas emanating from the Seminar will serve to set new frontiers of
knowledge in the subject.
(Dr. Aseem Chauhan)
National Conference on Drug Discovery and Formulation Development 23rd February 2016
Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus
Convener, NCDDFD 2016
Dy. Director, Amity Institute of Pharmacy
Amity University, Lucknow Campus
Message
It is matter of great pride that the team Amity Institute of Pharmacy is organizing a 3rd
national
scientific event. Drug Discovery with pace is need of hour in current scenario. We are fighting
with deadliest existing diseases and new outbreak like Zika virus infection. The researchers
across the world have no other choice but to work together. The budding students and
researchers need exposure to newer technology and scientific finding.
I am sure that National Conference on Drug Discovery and Formulation Development will serve
its important role in giving a common platform for new generation to interact and share ideas
with eminent scientist and academician. I welcome all the delegates to AMITY and thank you for
making this conference a great success.
(Dr. Sajal Srivastava)
National Conference on Drug Discovery and Formulation Development 23rd February 2016
Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus
Parmesh K. Dwivedi
(Treasurer-NCDDFD 2016)
I am extremely delighted to greet and welcome you all to National conference on Drug
discovery and formulation development. Theme of the conference has much significance as the
drug discovery and formulation development are the heart of pharmaceutical research. Now a
days, the process for research and development of new medicines is growing in difficulty and
length. Hence, the goal of this conference is to bring together researchers, academicians, industry
persons and learners to exchange their research ideas and results. We look forward to an
exciting day of insightful presentations, discussions and sharing of technical ideas with
colleagues from different parts of our country.
I hope and expect that the theme will result in fruitful and passionate discussions.
National Conference on Drug Discovery and Formulation Development 23rd February 2016
Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus
Responsibility Matrix:
S.
No
.
Committee
Name
Faculty Incharge/
Co-incharge
Student Name Programme Phone No.
1 Overall
Coordinator
Dr. Sajal Srivastava Ms. Priyanka
Srivastava; Ms.
Shivani Singh
B. Pharm 9839030220
9415054170
2 Marketing Dr. Sajal Srivastava,
Mr. Parmesh K
Dwivedi, Dr. Rahul
Shukla
Ms. Priyanka
Srivastava
B. Pharm 9839030220
3 Invitation Dr. M V Ramana, Dr.
Sajal Srivastava
4 Hospitality Mr. Amrit K Singh Mr.
Prakash Deep
Mr. Shushant
Mishra and Mr.
Anshu Singh
B. Pharm 6th
sem
8853933214
8953591757
5 MC Mr. Saikat Sarkar 1. Ms. Priyanka
Srivastava Ms
Alka Rai; 2. Parth,
Abhishek3. Mr.
Anurag
B. Pharm
B Pharm
M Pharm
9839030220
6 Transport Mr. Rahul Shukla Mr. Shunbam
Pandey Mr. Rahul
Kushwaha
Mr. Vikas
Upadhyay
B. Pharm 9616511037
8174838048
7 Reception Ms Nimisha Ms. Richa
Srivastava;
Ms. Nishita and
Ms Komal
Akansha lal
Ph. D.
B. Pharm
9936824032
8 Hall
Management
Dr . Zeeshan Fatima;
Dr. Himani Awasthi
Ms. Sristi raj and
Shreya
Pooja Yadav
B Pharm
B. Pharm 8th
sem
8102734585
7398517685
National Conference on Drug Discovery and Formulation Development 23rd February 2016
Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus
9 Disciplinary Mr. P. P. Dash; Ms.
Richa Srivastava
Mr. Rahul Pal and
Mr. Abhishek
Pandey; Ankan
Rastogi and
Shubham
Kesarwani; Mr.
Himanshu Jaiswal
and Mr. Prasoon
Dwivedi
B. Pharm 8726982698
9044999769
8090225216
10 Registration Ms Nimisha Ms. Richa
Srivastava;
Ms. Nishita and
Ms Komal
11 Accommodati
on
Ms. Neha Mathur and
Mr. Saikat Sarkar
Ravindra,
Rajeshwar and
vimal
B. Pharm 8th
sem
9807801157
9795910460
8960239311
12 Poster Display Dr. Mohini Chaurasia Ms. Shivani Singh
Ms Akansha Lal
B. Pharm 8th
sem
9415054170
8899309635
13 Certificate Mr. P K Dwivedi Mr. Vidhu
shekhar Dixit
Mr. Zeeshan
Ahmad
B. Pharm 6th
Sm
7398221508
14 Saraswati
vandana
Dr. Sajal Srivastava Ms. Mini Singh;
Ms Ankita Singh;
Ms. Kashish
Kapoor
B. Pharm 9688623489
15 Printing,
Publishing
Media & Press
Dr. Sajal Srivastava,
Mr. Ashutosh Chaubey
Ms. Rahul
Kushwaha
B. Pharm 7688623419
16 Abstract
Screening
& Printing
Dr. Sajal Srivastava Mr. Himanshu B. Pharm VI 8765812332
17 Rapporteur Ms. Neha Mathur; Ms.
Suchita
Mr. Vimal Misra B. Pharm 8th
sem
8960239311
National Conference on Drug Discovery and Formulation Development 23rd February 2016
Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus
SL. NO.
AUTHORS POSTER NO.
TITLE
1 LUBNA AZMI,, ILA
SHUKLA, SHYAM
SUNDAR GUPTA,
PADAM KANT,
CH.V.RAO
PO301 ULCER PROTECTIVE EFFECT OF ARGYREIA
SPECIOSA METABLOLITES ON PROBIOTIC
BACTERIA
2 SANGEETA BAJPAI, D.K.AWASTHI
PO302 FORMULATION OF XANTHINE IN THE
TREATMENT OF BRONCHITIS
3 RICHA SRIVASTAVA,
SAJAL
SRIVASTAVA
PO303 LIPOSOMAL DRUG DELIVERY OF
METHOTREXATE
4 PRITT VERMA, SHRAVAN K.
PASWAN, SURYA P.
SINGH, SAJAL
SRIVASTAVA, CH
V.RAO1
PO304 PROTECTIVE EFFECT OF ACACIA NILOTICA
(BARK) AGAINST ANTI TUBERCULAR DRUG
INDUCED HEPATIC DAMAGE AN
EXPERIMENTAL STUDY
5 SHRAVAN K. PASWAN, PRITT
VERMA, ALOK
R.GAUR, ABHISEK
RAJ, CH.V. RAO,
SAJAL
SRIVASTAVA
PO305 ANTIOXIDANT AND WOUND HEALING
PROPERTIES OF PHYLA NODIFLORA AGAINST
EXCISION WOUND HEALING ACTIVITY
6 ILA SHUKLA, LUBNA AZMI,
SHYAM SUNDAR
GUPTA, PADAM
KANT, CH.V.RAO
PO306 ANTI HEPATOTOXIC ACTIVITY OF MORUS
ALBA IN RAT MODEL OF ALCOHOL LIVER
DISEASE
7 MARYAM SARWAT
PO307 LAMP BASED APPROACHES FOR
AUTHENTICATION OF TRIBULUS TERRESTRIS
8 MADAN SWATI
PO308 PHYTOCHEMICAL ANALYSIS AND FREE-
RADICAL SCAVENGING ACTIVITY OF
FLACOURTIA INDICA (BURM.F.) MERR.
9 NESAR AHMAD, NOORUL HASAN,
ZEESHAN AHMAD,
ARUN KUMAR,
SHEIKH
ZOHRAMEENA
PO309 DICLOFENAC SODIUM: TREATMENT OF
RHEUMATIC DISEASES
10 NOORUL HASAN, PO310 INTRANASAL DELIVERY: AN APPROACH TO
National Conference on Drug Discovery and Formulation Development 23rd February 2016
Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus
NESAR AHMAD,
ZEESHAN AHMAD,
ARUN KUMAR,
SHEIKH
ZOHRAMEENA
FURRUKH AHMAD
BYPASS THE BLOOD BRAIN BARRIER
11 ZEESHAN AHAMD, ARUN KUMAR,
KULDEEP SINGH,
S.P. SINGH, MD.
ZISHAN,
PARAMDEEP
BAGGA
PO311 NANOCOSMETICS: AN OVERVIEW
12 MOHAMMAD AMIR, ZEESHAN
AHMAD, MD.
ZISHAN, ARUN
KUMAR, KULDEEP
SINGH, S.P. SINGH
PO312 PULMONARY DRUG DELIVERY
13 MOHAMMAD ZISHAN, ZEESHAN
AHMAD, VASEEM
A. ANSARI, S. P.
SINGH, FAISAL
SAEED,
MOHAMMAD AMIR
PO313 RECENT TRENDS IN RECTAL DRUG
DELIVERY SYSTEM
14 SAHAR IDRIS, AIJAZ AHMAD, MD.
ZISHAN, ARUN
KUMAR,
MOHAMMAD
AMIR, NAZMA
KHAN
PO314 TARGETED DRUG DELIVERY TO CNS USING
NANOPARTICLES
15 ASHUTOSH PATHAK,
MITHILESH
KUMAR,
HIMANSHU
MISHRA
PO315 CANCER VACCINE: AN INNOVATIVE
APPROACH IN CANCER TREATMENT
16 NEHA MATHUR, RAVI KUMAR,
KANKSHI TIWARI,
SUPRIYA SINGH,
NIKHAT FATIMA
PO316 EVALUATION OF QUALITY CONTROL
PARAMETERS ON VARIOUS BRANDS OF
PARACETAMOL TABLET FORMULATION
17 SAURABH PO317 AN EXCELLENT VEHICLE FOR NOVEL DRUG
National Conference on Drug Discovery and Formulation Development 23rd February 2016
Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus
SRIVASTAVA,
SHADAB
MOHAMMAD,
SANA FAROOQUI,
DEVENDRA
KUMAR
DELIVERY SYSTEM: BIODEGRADABLE
POLYMERIC NANOPARTICLES
18 KARUNA S. SHUKLA, MONIKA,
SHAILENDRA
PANDEY, POOJA
CHAWLA
PO318 THIAZOLIDINE-2, 4-DIONE & ITS ANALOGUES
AS ANTICANCER MEDIATED BY DEPLETION
OF INTRACELLULAR CALCIUM: A REVIEW
19 MARYAM SARWAT PO319 DNA FINGERPRINTING OCIMUM BASILICUM
AND O. SANCTUM THROUGH RAPD MARKERS
20 MONIKA, KARUNA SHANKER
SHUKLA,
SHAILENDRA
PANDEY, POOJA
CHAWLA
PO320 SIMULTANEOUS ESTIMATION OF
PIOGLITAZONE AND LOVASTATIN BY RP-
HPLC
21 MAYANK KULSHRESHTHA,
MANJUL PRATAP
SINGH
PO321 DOUBLE PYLORUS: AN UNCOMMON
FEATURE OF STOMACH
22 GUNJA SRIVASTAVA,
MANJUL PRATAP
SINGH, ANURAG
MISHRA
PO322 TRITERPENOIDS: A POTENT
HEPATOPROTECTIVE AGENT
23 SHAISTA SUHAIL, KUMUD NIGAM,
SAURABH
SRIVASTAVA
PO323 CURCUMIN AS A DRUG IN TREATMENT OF
ORAL CANCER
24 M.V. RAMANA, KAMAL DUA
PO324 FORMULATION AND EVALUATION OF
METOPROLOL TARTRATE MICROSPHERES
25 SHUBHAM SHARMA, NIMISHA
MISHRA
PO325 MODEL-BASED DRUG DEVELOPMENT:
APPLICABLE TO ONCOLOGY
26 SATYENDRA K RAJPUT,
VARSHALA PAL,
ARUN K SHARMA,
SHYAM SUNDAR
AGRAWAL
PO326 EFFECT OF BUXUS WALLICHIANA BAILL
EXTRACT AGAINST EXPERIMENTAL
INDUCED AMNESIA IN SWISS ALBINO MICE
27 PRATIBHA GUPTA, ANUPUM KUMAR
PO327 FORMULATION DEVELOPMENT &
CHARACTERIZATION OF ETHOSOMAL GEL
National Conference on Drug Discovery and Formulation Development 23rd February 2016
Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus
SACHAN
APPROVED FOR THE TREATMENT OF
ARTHRITIS
28 MRIDUL RAJEEV, NIKHAR SHUKLA,
MONIKA KAMBOJ
AND RICHA KHARE
PO328 NANO PARTICLES IN DRUGS
29 NIKHAR SHUKLA, MRIDUL RAJEEV,
SMRITI KHARE
AND RICHA KHARE
PO329 ROLE OF BIOTECHNOLOGY IN
PHARMACEUTICALS
30 UPASANA YADAV PO330 IMPACT OF CHITOSAN NANOPARTICLE IN DRUG DELIVERY
31 KALPANA SONWANI,
ASHUTOSH
KUMAR YADAV
PO331 CHEMICAL CONSTITUENTS AND PARTS OF
PLANTS AS IMMUNOMODULATORS
32 POOJA RAO, DHARAMVEER
PO332 CLINICAL BENEFITS OFHERBAL BASED ADAPTOGENS
33 RICHA MISHRA,
ASHUTOSH
KUMAR YADAV
PO333 ANIMAL MODELS FOR THE STUDY OF STRESS
VULNERABILITY RESILIENCE
34 JYOTI GUPTA, MAYANK
KULSHRESHTA
PO334 NATURAL MEMORY BOOSTERS IN INDIAN
HERBAL PLANTS
35 GARIMA SINGH, DHARAMVEER
PO335 CHRONIC UNPREDICTABLE STRESS:A
CLASSICAL MODEL OF DEPRESSION
36 SARASVATEE KUMARI,
ASHUTOSH
KUMAR YADAV
PO336 FLAVONOIDS AS AN ANALGESIC,
ANTIPYRETIC AND ANTI-INFLAMMATORY
AGENT
37 KHUSHABOO SINGH,
DHARAMVEER,
MAYANK
KULSHRESHTHA
PO337 ROLE OF -AMYLOID PROTEIN IN ALZHEIMER DISEASE
38 DEEPA SHUKLA, SAJAL
SRIVASTAVA,
TALHA JAWAID
PO338 A REVIEW ON EFFECT OF ANXIETY AND
STRESS ON MEMORY
39 SACHIN NEEKHRA,
ROHIT VERMA
PO339 EVALUTION OF HEPATOPROTECTIVE
POTENTAIL OF ALCOHOLIC AND AQUEOUS
EXTRACT OF TERMINALIA BELERICA IN RATS
40 DAN BAHADUR ROKAYA, HIMANI
PO340 MECHANISTIC APPROACHES OF DIFFERENT
National Conference on Drug Discovery and Formulation Development 23rd February 2016
Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus
AWASTHI MODELS OF ALZHEIMERS DISEASE
41 UPASANA YADAV, ARCHNA TIWARI
PO341 METALORGANIC-FRAMEWORK NANOPARTICLE AS A POTENTIAL FOR DRUG
DELIVERY AND IMAGING
42 CHANDNI TANDON, PRITI
MATHUR AND
MANODEEP SEN
PO342 WILDLY GROWING PLANTS AS A SOURCE OF
AN ALTERNATE MEDICINE: A POSSIBLE
DRUG DEVELOPMENT STRATEGY
43 MONA PAL
PO343 JAPANESE ENCEPHALITIS
44 SANNI GANGWAR
PO344 ANTIVIRAL & ANTIRETROVIRAL
45 PARUL TRIPATHI, PARUL JOHRI,
ADITI SINGH
PO345 ATOMIC LEVEL ANALYSIS OF ENVELOP
PROTEIN FROM DIFFERENT STRAINS OF HIV
VIRUS
46 SARITA JHA,
PARUL JOHRI,
MALA TRIVEDI
PO346 PROTEOME WIDE INTERACTION ANALYSIS
OF MITOCHONDRIAL PROTEINS
47 RUCHI YADAV, A.B.PANT, PRACHI
SRIVASTAVA
PO347 MOLECULAR DOCKING OF RESVERATOL
WITH HIGH THROUGHPUT
NEURODEVELOPMENT INJURY DATA
UNLOCKS POTENTIAL DRUG TARGETS
48 CHETAN RASTOGI, MOHD.MUDDASSIR
KHAN, SHRAVAN
PASWAN, PREET
VERMA, ALOK
RANJAN GAUR,
CH. V. RAO, SAJAL
SRIVASTAVA
PO348 EFFECT OF DESMODIUM GANGETICUM ON
ETHYLENE GLYCOL INDUCED
NEPHROLITHIASIS IN RATS
49 MOHD. MUDDASSIR
KHAN, CHETAN
RASTOGI , PREET
VERMA, SHRAVAN
PASWAN, ALOK
RANJAN GAUR, CH.
V. RAO,. SAJAL
SRIVASTAVA
PO449 EFFECT OF BERBERIS ARISTATA ON
STREPTOZOTOCIN INDUCED DIABETIC IN
RATS
50 SHIKHAR VERMA, ABHISHEK GUPTA,
M.V. RAMANA, A.K.S
RAWAT
PO350 HPTLC ANALYSIS FOR THE QUANTIFICATION
OF GALLIC ACID AND QUERCETIN IN
National Conference on Drug Discovery and Formulation Development 23rd February 2016
Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus
METHANOLIC FRACTION OF LIMONIA
ACIDISSIMA L. FRUITS
51 ANKAN RASTOGI, MUSAB RAFI,
HIMANSHU
JAISWAL
PO351 AN ABSTRACT ON NATURAL ANTIOXIDANTS
52 SHWETA SACHAN, PARUL JOHRI, ADITI
SINGH
PO352 GLYCOSYLATION IN LIPASE ENZYME OF
HOMO SAPIENS AND ITS CORRELATION
WITH CARBON COMPOSITION
53 JYOTI WAGH, SANDEEP,
ASHUTOSH MISHRA,
RAHUL SHUKLA,
SAIKAT SARKAR,
SUMIT GUPTA
PO353 YOGA: LIFE OF SCIENCE
54 ASHUTOSH MISHRA, RAHUL SHUKLA,
SANDEEP
PO354 PREVENTIVE MEASUREMENTS TO STRESS IN
CURRENT ENVIRONMENT
55 ANKITA TRIPATHI, SURAJ NEUPANE
PO355 A REVIEW ON NECROTIZING FASCIITIS-A
LIFE THREATNING INFECTION OF SKIN AND
SOFT TISSUES
56 SANDEEP, ANGSHU BANARJEE,
ABHILASA, RAHUL
SHUKLA,
ASHUTOSH sMISHRA
PO356 EVALUATION OF PERIPHERAL ANALGESIC
ACTIVITY OF BARK OF ANNONA SQUAMOSA
FROM GONDA REGIONs
National Conference on Drug Discovery and Formulation Development 23rd February 2016
Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus
Invited talk
" An introduction to Drug Discovery by rational approach and
applications of Green Chemistry in Drug Synthesis"
Prof. Dr. J. Saravanan, Principal,
PES College of Pharmacy,50 feet road,
Hanumanthnagar,Bangalore- 560 050,
email : [email protected].
Abstract
Rational drug discovery is a more streamlined process that requires careful consideration of the
target of the drug as well as the drug itself. This method of drug design uses special equipment to
examine the three-dimensional structure of a drug target and then find a compound that can
interact with the target. Rational drug design therefore requires sound knowledge of chemistry as
well as biology, because chemical interactions between drugs and their targets are what
determine whether a drug is biologically active.
Discovery of new drugs by serendipity and random screening is no more appropriate, instead
drug discovery by rational approach involving techniques like bioisosterism , enzyme inhibition
, consideration of Lipinski rule of five and so on.
The term green chemistry is defined as the invention, design and application of chemical
products and processes to reduce or to eliminate the use and generation of hazardous
substances. Green chemistry can diminish the need for other approaches to environmental
protection. Ideally, the application of green chemistry principles and practice renders regulation,
control, clean-up, and remediation unnecessary, and the resultant environmental benefit can be
expressed in terms of economic impact.
Microwave assisted organic synthesis has revolutionized organic synthesis. Small molecules can
be built in a fraction of the time required by classical thermal methods. As a result, this
technique has rapidly gained acceptance as a valuable tool for accelerating drug discovery and
development processes.
National Conference on Drug Discovery and Formulation Development 23rd February 2016
Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus
PO301
ULCER PROTECTIVE EFFECT OF ARGYREIA SPECIOSA METABLOLITES ON
PROBIOTIC BACTERIA
Lubna Azmi1*
,, Ila Shukla
2, Shyam Sundar Gupta
1, Padam Kant, Ch.V.Rao
1 Pharmacognosy and Ethnopharmacology Division, CSIR-NBRI, Lucknow, India
2 University of lucknow , Lucknow, Uttar Pradesh, India
E-mail: [email protected]
In the present study, the 50 % w/w ethanolic extract of natural occurring medicinal plant
Argyreia speciosa (L.f), sweet (Family Convolvulaceae) was studied for antioxidant, antiulcer
activity and its purified secondary metabolites were assessed for growth promoting effects on
probiotic bacteria Lactobacillus casei. The gastric ulcers were significantly decreased by all
doses of ASE and probiotic combination as compared with the indomethacin (25 mg/kg body
weight) treated group. In the stomach tissues of treated animals, antioxidant levels were
examined. The administration of indomethacin caused a significant decrease in the levels of
superoxide dismutase (SOD), glutathione peroxidise (GPx) and reduced glutathione (GSH), and
a raise in the lipid peroxidation (LPO) level (p < 0.05). The administration of all doses of ASE
reversed the trend, call to mind a significant increase of SOD, GSH and GPx levels and a
reduction in LPO level in tissues. However, catalase (CAT), glutathione reductase (GR) and
myeloperoxidase (MPx) activities, increased by indomethacin, were found to be lower in the
ASE, probiotic combination of ASE + L.casei and omeprazole-treated groups. The gastric
mucosal constitutive NO synthase (cNOS) and inducible NO synthase (iNOS) activities were
also investigated in tissues of ASE (100 mg/kg), ASE (100 mg/kg) + L. casei (10-8
con.),
omeprazole and indomethacin-treated rat groups. The administration of ASE + L.casei and
omeprazole increased the cNOS activity and lowered the iNOS activity as compared with
indomethacin-treated group. As far as the growth promoting effects of ASE metabolites on L.
casei is concerned, querecetin showed high growth stimulating activity in increased dry matter of
biomass. At low pH growth promoting activity of metabolite was found stable.
Keywords: Argyreia speciosa, Antioxident activity, Antiulcer activity, Indomethacin
National Conference on Drug Discovery and Formulation Development 23rd February 2016
Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus
PO302
FORMULATION OF XANTHINE IN THE TREATMENT OF BRONCHITIS
Sangeeta Bajpai*1, D.k.Awasthi
2
1School of Applied Sciences Amity University Lucknow U.P.
2Department of Chemistry Sri J.N.P.G. College Lucknow U.P.
Email: [email protected]
Methylxanthines are used for the preparation of group of drugs. These are playing very important
for smoothing of bronchial muscles and stimulate central nervous system (CNS).The
bronchodilator effects of such drugs are applied in the treatment in acute asthma. Such drugs are
also used in the treatment of aponea and have diuretic effect. Oxpentifylline, is a Xanthine
derivative acts as vasodilator. Naturally occurring are caffeine, theophylline and theobromine.
Their derivatives can be used in the improvement form for the treatment of asthma. Modified
forms are Diprophylline, Etamiphylline Camsylate, Proxyphylline and Hydroxytheophylline,
Etofylline. They can be prepared and sell into the market as tread names. Aminophylline,
Aminophylline Hydrate, Choline Theophyllinate. Theobromine is also used in the treatment of
angina pectoris and hyper tension. The basic nucleus is xanthine. It can be substituted by various
groups for the preparation more effective drugs. Now days air pollution is fast growing and
Indian citizens are suffering from respiratory problems. More emphasis is required on bronchial
drugs and treatment of bronchitis, asthma, emphysema and acute respiratory infection .we feel
among such drugs Aminophylline would be better. It can be given orally as well as through
injection.
National Conference on Drug Discovery and Formulation Development 23rd February 2016
Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus
PO303
LIPOSOMAL DRUG DELIVERY OF METHOTREXATE
Richa Srivastava*, Sajal Srivastava
Amity Institute of Pharmacy, AUUP, Lucknow Campus
Various advanced drug delivery systems such as nanoparticle which include polymeric micelles,
dendrimers , liposomes, SLN, have been investigated to overcome the limitation of the
conventional systems. Considering effectiveness of drug therapy of methotrexate (MXT), the study
focused on formulation of liposomes. The objective of this study was to achieve desired
entrapment of methotrexate in liposome. Liposomes were prepared by thin film hydration method
The liposome were prepared and characterized by, zeta potential for surface charges and particle
size analysis done by Malvern nanosizer and average particle size and zeta potential was found
to be 169 nm and -16.9mV respectively. Liposomal formulations as carrier system for MTX
destined for treatment of cancer by passive targeting Dynamic in vitro drug release was carried
out using phosphate buffer pH 7.4. A short term stability studies was conducted for 2 months at
40C and at room temperature (25
0C). Final formulations were prepared after lyophilizing the
selected liposomes.. MTX entrapped in the liposomes and the entrapment efficiency was found
to be 83 %. The drug loading and entrapment efficiencies were evaluated by a HPLC method
(C18 column 5m, 150mm4.6mm,50mM ammonium acetate/acetonitrile mobile phase v/v 3.0
ml/min flow rate and 256 nm UV detection).The evaluation studies of different processing
variables like drug to lipid ratio, soya lecithin to cholesterol ratio, temperature were evaluated .
KEY WORDS: Liposomes, lyophilization, drug release.
National Conference on Drug Discovery and Formulation Development 23rd February 2016
Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus
PO304
PROTECTIVE EFFECT OF ACACIA NILOTICA (BARK) AGAINST ANTI
TUBERCULAR DRUG INDUCED HEPATIC DAMAGE AN EXPERIMENTAL STUDY
Pritt Verma*1,2
, Shravan K. Paswan1,2
, Surya P. Singh1, Sajal Srivastava
2, Ch V.Rao
1
1Pharmacognosy and Ethnopharmacology Division, CSIR- BRI, Lucknow, India.
2Amity Institute of Pharmacy, Amity University, Lucknow Campus, India.
Rats were divided into five different groups (n=6), the group I served as a control, Group II
received Isoniazid-INH and rifampicin-RIF (50mg/kg) in sterile water, group III and IV served
as a treatment and received 200,400 mg/kg of 50% ethonolic extract of A. nilotica, and group V
served as standard group and received silymarin (100mg/kg). All the treatments were given for
10-28 days and after rats were authorized, blood and liver were collected for biochemical and
histopathological studies, respectively. The 50% ethanolic bark extract of A. nilotica (200, 400
mg/kg p.o.) showed the remarkable hepatoprotective effect against Isoniazid-INH and
rifampicin-RIF induced hepatic damage, and observed that it shows no any significant change in
a normal posture, behavior and body weight in Wistar rats. The degree of protection was
measured by biochemical and antioxidant parameters such as serum glutamate oxaloacetate
transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase
(ALP), total bilirubin, and the histopathological profile of liver also indicated the
hepatoprotective nature of this drug. The bark extract of A. nilotica has showed dose dependent
activity, among which at the dose level of 200 & 400 mg/kg. The further investigations, the bark
extract of A. nilotica identify the active constituents responsible for hepatoprotection.
Keywords: A. nilotica, Antioxidant, Isoniazid-INH, Rifampicin-RIF, Silymarin.
National Conference on Drug Discovery and Formulation Development 23rd February 2016
Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus
PO305
ANTIOXIDANT AND WOUND HEALING PROPERTIES OF PHYLA NODIFLORA
AGAINST EXCISION WOUND HEALING ACTIVITY
Shravan K. Paswan1,2
*, Pritt Verma1,2
, Alok R.Gaur1, Abhisek Raj
1, Ch.V. Rao
1, Sajal
Srivastava2
1Pharmacognosy and Ethnopharmacology Division, CSIR- BRI, Lucknow, India.
2Amity Institute of Pharmacy, Amity University, Lucknow Campus, India.
Leaf extract of Phyla nodiflora was developed as ointment (5% & 10% w/w) with easy ointment
base B.P. The ointment was then evaluated for excision wound healing activity. Parameters as
well as antioxidant, measurement of wound space &, wound contraction index, a measurement of
tensile strength and histopathological examination content were determined. Remarkable wound
healing activity was observed with the 10% (w/w) ointment of 50% ethonolic leaf extract of
Phyla nodiflora. Statistical analysis was performed by one-way analysis of variance followed by
t-test. Wound treated with 5% and 10% (w/w) 50% ethonolic leaf extract ointment exhibited
significant excision wound and antioxidant parameter, the healing activity of the excision wound
as evidenced by increased wound contraction, shorter epithelization time, higher tissue breaking
strength and increased hydroxyproline content. This plant has important biological activities and
responsible for the antioxidant and wound healing properties. The study provided sufficient
evidences that Phyla nodiflora might be indeed potential sources to treat many diseases.
Keyword-: Phyla nodiflora, Antioxidant, Histopathological, wound-space, wound contraction.
National Conference on Drug Discovery and Formulation Development 23rd February 2016
Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus
PO306
ANTI HEPATOTOXIC ACTIVITY OF MORUS ALBA IN RAT MODEL OF ALCOHOL
LIVER DISEASE
Ila Shukla1*, Lubna Azmi
2, Shyam Sundar Gupta
1, Padam Kant
2, Ch.V.Rao
1
1 Pharmacognosy and Ethnopharmacology Division, CSIR-NBRI, Lucknow, India
2 University of lucknow , Lucknow, Uttar Pradesh, India
E-mail: [email protected]
Alcoholic liver disease has a known aetiology but a complex and incompletely known
pathogenesis. It is an extremely common disease with signicant morbidity and mortality.
Therapy for treatment of it comes with lot of side effects. Presently there is a need of some
natural therapy with lesser side effects and more potential to treat the disease.
Present study is designed with an objective to investigate the antioxidant and
hepatoprotective activities of the ethanolic extract of the Morus Alba in rat model of alcohol
liver disease. Rats were divided into four groups of six each. Group-1 (control) is isocaloric
pairfed, Group-2 received ethanol at a dose of 6g/kg/day, Group- 3 and 4 were administered
extract of Morus Alba as an aqueous suspension orally along with alcohol. After eight weeks,
liver weight, liver function serum markers such as alkaline phosphatase (ALP), aspartate
transaminase (AST) and alanine transaminase (ALP) and lipid peroxidation were measured.
Aqueous suspension showed significant decrease in the levels of AST, ALT and ALP as
compared to alcohol-fed rats. Extract of Morus Alba ameliorated alcohol induced liver injury.
Keywords : Morus Alba, Hepatoprotective, Alcohol Liver Disease, Antioxidant, lipid
peroxidation.
National Conference on Drug Discovery and Formulation Development 23rd February 2016
Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus
PO307
LAMP BASED APPROACHES FOR AUTHENTICATION OF TRIBULUS TERRESTRIS
Maryam Sarwat*
Pharmaceutical Biotechnology, Amity Institute of Pharmacy, Noida, UP 201303
E mail: [email protected]; [email protected]
Plant based medicines are popular worldwide due to their negligible side effects. There is no
control over the quality of the raw material for medicinal plant use. There are various incidences
of adulteration of medicinal plants with useless weeds. Keeping this in mind, it is imperative to
authenticate the plant material before being used.
Our study plant Tribulus terrestris (Zygophyllaceae), has utmost medicinal importance in curing
urinary discharges, cough, asthma, pain, spermatorrhoea, ophthalmia, anemia, dysentery, skin
and heart diseases; The original use for T. terrestris extract was as a tonic to treat sexual
dysfunction. The plant get often confused with Kallstroemia parviflora and K. californica,
because of their similar morphology. These plants, often get accidentally mixed with T. terrestris
while collecting raw material for herbal drug preparations, making them less efficient or some
times toxic. Samples of this plant were collected from different geographical locations in India.
Random amplified polymorphic deoxyribonucleic acid (DNA) analysis of collected samples was
carried out with 24 random primers. A 510-bp DNA fragment, common to all accessions, was
eluted, cloned, and sequenced. Four LAMP primers were designed on the basis of sequence of
510 bp DNA fragment. LAMP reaction was performed at 65C for 1 h. The resulting amplicon
was visualized through SYBR Green I. LAMP using a primer set for T. terrestris and total DNA
extracted from T. terrestris leaves (0.510.0 ng) as template was detected up to 70 min. On the
other hand, in the reaction using a primer set for T. terrestris and total DNA from K. parviflora
as template, no amplifications were detected. The same tendency could be seen in the reactions
using a set of primers for K. parviflora. LAMP enabled not only identification but also detection
with high specificity. The data showed confirmatory results. Since the assay method is simple,
sensitive, and cost-effective, it is a feasible method for identifying and authentication of C.
roseus.
Keywords: Medicinal plants, authentication, Tribulus terrestris, trnk, LAMP based markers.
National Conference on Drug Discovery and Formulation Development 23rd February 2016
Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus
PO308
PHYTOCHEMICAL ANALYSIS AND FREE-RADICAL SCAVENGING ACTIVITY OF
FLACOURTIA INDICA (BURM.F.) MERR.
Madan Swati*
Amity Institute of Pharmacy, Amity University, Noida (U.P), India
Flacourtia indica (Burm.f) Merr. Syn. F. ramontchi L Herit (Flacourtiaceae) is a small spinous
tree or shrub found distributed throughout the Himalayas, northern districts of Uttar Pradesh,
Assam, Bengal and Orissa. The roots and fruits of F. indica are used in traditional medicine as a
diuretic, hepatoprotective and antidiabetic. Flacourtia indica dichloromethane (DCM) stem bark,
butanol (BuOH) stem bark, methanol (MeOH) stem bark and MeOH leaf extract were screened
for in vitro antioxidant activity using different models. Subsequent quantification showed the
presence of 15.62 and 11.53 % w/w phenolics; 1.15 and 1.80 % w/w of flavonol in methanol
extract of stem bark and leaf of Flacourtia indica (F. indica) respectively. The methanolic
extract of stem bark and leaf of F. indica showed an effective DPPH radical scavenging activity
with low IC50 values of 17.5 and 21 g/ml respectively. Butanolic extract of F. indica stem bark
showed nitric oxide radical inhibition activity with IC50 value of 28.5 g/ml. The methanolic
extract of stem bark showed hydroxyl radical scavenging by p-NDA method with IC50 value of
350.23 g/ml.
Key words: Flacourtia indica, DPPH, Nitric oxide radical inhibition assay, Scavenging,
hydroxyl radical, p-NDA
National Conference on Drug Discovery and Formulation Development 23rd February 2016
Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus
PO309
DICLOFENAC SODIUM: TREATMENT OF RHEUMATIC DISEASES
Nesar Ahmad*, Noorul Hasan, Zeeshan Ahmad, Arun Kumar, Sheikh Zohrameena
Integral University, Lucknow
E-Mail- [email protected]
Diclofenac is the medicine works by reducing substances in the body that causes pain and
inflammation. Diclofenac used to treat mild to moderate pain, or signs and symptoms
of osteoarthritis or rheumatoid arthritis. The Cataflam brand of this medicine is also used to treat
menstrual cramps. Diclofenac 75 to 150mg daily (25 to 50mg 3 times daily) is comparable in
efficacy with ordinary aspirin 3 to 5g daily and indomethacin 75 to 150mg daily in rheumatoid
arthritis and with indomethacin in osteoarthritis Diclofenac powder (Cambia) is used to treat
a migraine headache attack. It will not prevent headaches or reduce the number of attacks not use
Diclofenac. If patient have a history of allergic reaction to aspirin or NSAIDs it can increase the
risk of fatal heart attack or stroke, especially if he use it long term or take high doses, if he
suffering from heart disease. Although there is some evidence of Diclofenac efficacy when
administered twice daily, or once daily as a slow release tablet. The drug is also available as
suppositories and ampoules for intramuscular injection. It is not recommended just before or
after heart bypass surgery (coronary artery bypass graft or CABG). These conditions can occur
without warning while you are using this medicine, especially in older adults. No one of the non-
steroidal anti-inflammatory agents is the most suitable drug for all patients requiring such
therapy, and Diclofenac should be considered along with other drugs of its type in the arthritic
patient.
National Conference on Drug Discovery and Formulation Development 23rd February 2016
Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus
PO310
INTRANASAL DELIVERY: AN APPROACH TO BYPASS THE BLOOD BRAIN
BARRIER
Noorul Hasan*, Nesar Ahmad, Zeeshan Ahmad, Arun Kumar, Sheikh Zohrameena Furrukh
Ahmad
Faculty of Pharmacy, Integral University, Lucknow
E-Mail:- [email protected]
The blood brain barrier (BBB) represents one of the strictest barriers of in- vivo therapeutic drug
delivery. The barriers are restricted exchange of hydrophilic compounds, small proteins and
charged molecules between the plasma and central nervous system (CNS). For decades, the BBB
has prevented the use of many therapeutic agents for treating Alzheimers disease, stroke, brain
tumor, head injury, spinal cord injury, depression, anxiety and other CNS disorders. The
emerging approach is to bypass the BBB by intranasal delivery, which provides a practical, non-
invasive, rapid and simple method to deliver the therapeutic agents to the CNS. This method
works the unique connection between the nose and the brain that has evolved to sense odors and
other chemical stimuli. On the basis of clinical trials (Phase I and II) it is reported that the
intranasal route is feasible for the transport of the drug to the CNS. Intranasal delivery does not
require any modification of the therapeutic agents and does not require that drugs be coupled
with any carrier like in case of drug delivery across the BBB. A wide variety of therapeutic
agents, including both small molecules and macromolecules can be successfully delivered,
including to the CNS, using the intranasal method. Advantage of intranasal delivery are
Bypasses the BBB and targets the CNS, reducing systemic exposure and thus systemic side
effects and Avoids destruction in the gastrointestinal tract, hepatic first pass elimination and
gut wall metabolism, allowing increased, reliable bioavailability.
Key words: Alzheimers disease; Acetylcholine esterase, Buxus wullichiana; Locomotor,
Scopolamine, Donepezil
National Conference on Drug Discovery and Formulation Development 23rd February 2016
Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus
PO311
NANOCOSMETICS: AN OVERVIEW
Zeeshan Ahamd*, Arun Kumar, Kuldeep Singh, S.P. Singh, Md. Zishan, Paramdeep Bagga
Faculty of Pharmacy Integral University, Lucknow
E Mail: - [email protected]
Platus, a roman philosopher words, A woman without paint is like food without salt."
Nanocosmetics are any cosmetic containing nanoparticles. Nanoparticle is any entity with all
three external dimensions in the nanosize. The magnitude of size of particles in the range of 1 nm
to 100 nm is considered as nanoscale. Nanocosmetics was actually the first branch of
nanotechnology to be commercialized and marketed to consumers, according to Davis Baird.
Antiaging products are the most common example of nanocosmetics, with nanoparticles that go
beneath the surface of the skin and reduce the appearance of lines and wrinkles by reacting with
the body. Various forms of nanotechnology involved in cosmeceuticals like Nanoparticle,
Nanoemulsions, Bucky balls, Nanogel, Microgels Liposomes, Dendrimers, Cubosomes, Solid
Lipid Nanoparticles (SLNs). Recent researches focusing on cosmeceutical products highlighted
strong growth perspectives in the coming years. According to them expanding at a rapid
compound annual growth rate of 7.7%, the global cosmeceutical market will reach $31.84 billion
by 2016. The global cosmeceutical market offers huge potential among the Asian countries, such
as Japan, China, and India which are set to attract major players in the future. Japan has already
made a remarkable position in the global cosmetics market and its position in the cosmeceutical
segment is effectively improving. A report, Cosmeceuticals market to 2018, forecasted that the
global cosmeceuticals market will reach $42.4 billion by 2018.
National Conference on Drug Discovery and Formulation Development 23rd February 2016
Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus
PO312
PULMONARY DRUG DELIVERY
Mohammad Amir*, Zeeshan Ahmad, Md. Zishan, Arun Kumar, Kuldeep Singh, S.P. Singh
Faculty of Pharmacy, Integral University, Lucknow
Email: - [email protected]
The respiratory tract is one of the oldest routes used for the administration of drugs. Over the
past decades inhalation therapy has established. It is a valuable tool in the local therapy of
pulmonary diseases such as asthma or COPD (Chronic Obstructive Pulmonary Disease). This
type of drug application in the therapy of these diseases is a clear form of targeted drug delivery.
Currently, over 25 drug substances are marketed as inhalation aerosol products for local
pulmonary effects and about the same number of drugs are in different stages of clinical
development. Pulmonary delivered drugs are rapidly absorbed except large macromolecules
drugs, which may yield low bioavailability due to enzymatic degradation and/or low mucosal
permeability. Pulmonary bioavailability largely depends on the physical properties of the
delivered protein and it is not the same for all peptide and protein drugs. Pulmonary drug
delivery is important researches are an impacts the treatment of illnesses including asthma,
chronic obstructive pulmonary disease and various diseases. Inhalation gives the most direct
access to drug target. In the treatment of obstructive respiratory diseases, pulmonary delivery can
minimize systemic side effects, provide rapid response and minimize the required dose since the
drug is delivered directly to the conducting zone of the lungs.
National Conference on Drug Discovery and Formulation Development 23rd February 2016
Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus
PO313
RECENT TRENDS IN RECTAL DRUG DELIVERY SYSTEM
Mohammad Zishan, Zeeshan Ahmad, Vaseem A. Ansari, S. P. Singh, Faisal Saeed,
Mohammad Amir
Faculty of Pharmacy, Integral University, Lucknow U.P. India-226026
E mail: - [email protected]
There are many routs to deliver drugs into the body viz oral (through swallowing), sub mucosal
(through buccal and sublingual mucosa), parenteral (through injection), transdermal (through
skin), pulmonary (through inhalation) etc. Among these deliveries rectal routs is widely
accepted. Rectum delivery uses the rectum as a rout of administration for medication and other
fluids which are absorbed by the rectums blood vessels and flow into the bodys circulatory
system which distributes the drugs to the bodys organs. There are many advantages of the rectal
drug delivery system it avoidance of GI metabolism and degradation. The rectal route of
administration is useful for patients who cannot swallowed, Avoidance of irritation to the
stomach, partial avoidance of first pass metabolism, Rapid absorption of many low molecular
weight drugs. Prolonged effect, Absorption enhancement, Rate control drug delivery .There are
many drugs which are available in the market which are applied to rectal route like creams, gels,
suppositories, suspensions and rectal aerosols. Suppositories are available in two forms like solid
suppositories, liquid suppositories, Suppositories are medicated solid bodies suitably shaped for
rectal administration rectal drug delivery systems used the deliver the drug by using
mucoadhesive polymers in through the mucous of the rectum. Rectal drug delivery is so
medicated when the oral medication is not possible.
National Conference on Drug Discovery and Formulation Development 23rd February 2016
Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus
PO314
TARGETED DRUG DELIVERY TO CNS USING NANOPARTICLES
Sahar Idris*, Aijaz Ahmad, Md. Zishan, Arun Kumar, Mohammad Amir, Nazma Khan
Faculty of Pharmacy, Integral University, Lucknow
Nano technology plays a unique and pivotal role in the development of brain specific drug
delivery, imaging and diagnosis. Targeted drug delivery is a means of concentrating dugs at a
specific site relative to other parts of the body. It spares the rest of the body from toxic effects of
the drug and is also a potential means of improving therapeutic index. The delivery of drugs to
the CNS is of prime importance for treating specific neurological disorders and various diseases
such as Meningitis, Encephalitis, degenerative diseases such as Alzheimer, Parkinsons and
tumors such as Glioblastoma. The major problem in treating such CNS disorders is due to their
inability to surpass the natural CNS protective barriers, mainly the Blood Brain Barrier and the
Blood cerebrospinal fluid Barrier. Nanoparticle systems in CNS targeted drug therapy provide
better penetration of therapeutic and diagnostic agents, and a reduced risk in comparison to
conventional treatments. By using nanotechnology it is possible to deliver the drug to the
targeted tissue across the BBB, release the drug at a controlled rate, and avoid degradation
processes. Different types of nanoparticles used for CNS targeted drug delivery like inorganic
nanoparticles, Polymeric Nanoparticles, Solid Lipid Nanoparticles, Nano crystals, Carbon
nanotubes, Dendrimers, Quantum Dots, Gold Nanoparticles and Magnetic Nanoparticles.
National Conference on Drug Discovery and Formulation Development 23rd February 2016
Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus
PO315
Benzothiazole: Different Methods of Synthesis and Diverse Biological
Activities
Desh Deepak Pandey*, Dr Dilip Kumar Pal
Rameshwarm Institute of Technology and Management Lucknow
Substituted 1, 3-benzothiazole derivatives are an important class of heterocyclic compounds. In
recent years heterocyclic compounds analogues and derivatives have attracted strong interest due
to their biological and pharmacological properties. The benzothiazole nucleus containing
compounds involved in research aimed at evaluating new products that possess biological
activities, such as antimicrobial, anticancer, antifungal, anthelmintic, anti-diabetic, amyloid
imagining agents and anticancer agents. The present review focus on the different methods of
synthesis of substituted benzothiazoles with potential activities that are now in developing phase.
Benzothiazole is a heterocyclic compound, weak base, having varied biological activities and
still of great scientific interest now a days. They are widely found in bioorganic and medicinal
chemistry with application in drug discovery. Benzothiazole moites are part of compounds
showing numerous biological activities such as antimicrobial anticancer anthelmintic anti-
diabetic activities.
Keywords: Substituted benzothiazole derivatives, antibacterial activity, anticancer activity, anti-
diabetic activity.
4
5
9
6
8
7
N3
2
S1
1,3-benzothiazole
Chemicals and other reagents required for the synthesis will be procured from standard company
sources. Compounds will be synthesized by using standard procedures. The reactions will be
monitored by TLC and purification of the compounds will be carried out by recrystallization method
using suitable solvent. The synthesized compounds will be characterized by preliminary laboratory
techniques such as melting point, boiling point etc. Compounds synthesized will be confirmed by
FTIR, Mass Spectroscopy and NMR spectral data.
N
S
R
R1
National Conference on Drug Discovery and Formulation Development 23rd February 2016
Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus
PO316
CANCER VACCINE: AN INNOVATIVE APPROACH IN CANCER TREATMENT
Ashutosh pathak*, Mithilesh Kumar, Himanshu Mishra
Kamla Nehru Institute of Management & Technology, Sultanpur (U.P)
Cancer became a big question for scientific community as no existing treatments could
solve this dreadful disease. Research is in well progress since half century but it failed to give a
right solution to fight against it. One such mile stone treatment for cancer that is giving good
hope to the people is cancer vaccines. Cancer vaccines are made from the persons own cancer
cells or from cells that are grown in a laboratory. Tumor vaccines are often based on DNA
construct viral vectors and cytokines that have been determined as safe. From previous clinical
trials Peptide vaccines are generally safe so long as the cytokine adjutants are used in
combinations and doses previously determined to be safe. A patient with pulmonary metastasis
of colon cancer was treated with artificially synthesized helper/killer-hybrid epitope long peptide
(H/K-HELP) of MAGE-A4 cancer antigen. The patient was vaccinated with MAGE-A4-H/K-
HELP combined with OK432 and Montanide ISA-51. There were no severe side-effects except
for a skin reaction at the injection site.
Antigen based tumor vaccines do not involve the insertion of modified tumor cell or immune cell
into the body. Instead, purified tumor proteins (antigens) are injected to stimulate the patients
antigen presenting cells (APCs) to take up the antigen and present it to T cells.
Keywords: Antigen presenting cells (APCs), cytokines, Peptide vaccines, Montanide
National Conference on Drug Discovery and Formulation Development 23rd February 2016
Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus
PO317
EVALUATION OF QUALITY CONTROL PARAMETERS ON
VARIOUS BRANDS OF PARACETAMOL TABLET FORMULATION
*Neha Mathur, Ravi Kumar, Kankshi Tiwari, Supriya Singh, Nikhat Fatima
Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow, India.
Paracetamol (Acetaminophen) is a widely used OTC medicine available as compressed tablets. It is
marketed and manufactured by a number of pharmaceutical companies and is widely used as an
analgesic, antipyretic medicine. In the present study we selected three brands of Paracetamol tablets
(Brand X, Brand Y and Brand Z) which are easily available and commonly used for analgesic and
antipyretic action. Further, the purpose of the present study was to perform the various quality
control tests of the compressed tablets like, weight variation, hardness, friability, disintegration and
dissolution as per the official monographs B.P, U.S.P and evaluate these three different brands. As a
result of this study we found that all the three brands met the specifications laid down in the
official monographs. They differ only slightly in terms of various quality control parameters,
brand Z disintegrated faster, had faster dissolution rate and so its % drug release was more than
the other two brands at the same time.
National Conference on Drug Discovery and Formulation Development 23rd February 2016
Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus
PO318
AN EXCELLENT VEHICLE FOR NOVEL DRUG DELIVERY SYSTEM:
BIODEGRADABLE POLYMERIC NANOPARTICLES
Saurabh Srivastava1*
, Shadab Mohammad1, Sana Farooqui
1, Devendra Kumar
2
1Department of Oral Pathology & Microbiology, King Georges Medical University Lucknow, Uttar Pradesh, India
2Department of Pharmacology and Therapeutics, King Georges Medical University, Lucknow, Uttar Pradesh, India
Email: [email protected]
Nanotechnology is new concept, it has been included biomedical, drug delivery, diagnostic,
imaging and mainly focusing in treatment and diagnosis of cancer & other disease state.
Nanoparticles (NPs) have unique and specific properties in terms of chemical and biological by
their small size ranges (1-100 nm) to have a surface area to volume ratio, which allows them to
combine, absorb and hold other compounds like drugs molecules, DNA, RNA, proteins.
Furthermore, their small size, shape and surface and other favourable characteristics helps the
drug therapy to become more stable, targeted, carrier orientated and incorporate with both
hydrophilic and hydrophobic substances. Biodegradable polymeric nanoparticles are the carriers
or vehicle where therapeutic agents can be encapsulated in their matrix and conjugated for
targeted delivery of a number of drugs. The site specific properties of biodegradable polymer as
nanoparticles reduce local pH and affecting cells microenvironment. There are many
biodegradable polymers use for drug delivery and classified synthetic, examples are poly (lactic
acid), poly (caprolactone), poly (glycolic acid), poly (lactic- co- glycolic acid), poly
(trimethylene carbonate), poly (butylenes succinate), poly (p-dioxanone), poly (butylenes
terephthalate), degrapol, hybrane, poly [(caboxyphenoxy) propane-sebacic acid], poly [bis
(hydroxyethyl) terephthalate-ethyl orthophosphorylate terephthaloyl chloride], poly (ethylene
glycol), poly (ortho esters), tyrosine derived, polycarbonate and semi-synthetic polymers are
poly (- hydroxyalkanoate), poly (hydroxybutvrate), poly (hydroxybutyrate-co-hydroxyvalerate)
and natural polymers are collagen, albumin, chitosan, gluten, hyaluronate, cellulose, alginate,
starch. These biodegradable polymers are non-toxic and completely eliminated and degradation
occurs by oxidation enzymatic reaction or hydrolysis. So that it is very safe and effective vehicle
for delivering drug nanoparticles by increasing the degradation rate of polymeric matrix for
targeted delivery of drugs within the effected cells.
National Conference on Drug Discovery and Formulation Development 23rd February 2016
Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus
PO319
DNA Fingerprinting Ocimum basilicum and O. sanctum through
RAPD Markers Maryam Sarwat*
Pharmaceutical Biotechnology, Amity Institute of Pharmacy, Noida, UP 201303
E mail: [email protected]; [email protected]
India is a hotspot of biodiversity and is home to a wide variety of medicinally and economically
important plants. A number of techniques were being used from time immemorial for correct
identification of medicinal plants. Molecular markers being independent of any environmental
cues or developmental stage are proved to be very helpful in distinguishing valuable medicinal
plants from their adulterants. Ocimum from Lamiaceae is considered as queen of herbs. Most of
its species are used in traditional medicinal system against cough, cold flu, head and ear
infection, arthritis, rheumatism, malaria, fever, allergies and various skin diseases.
Leaf samples were collected from Lucknow, Delhi, NOIDA, Jaipur and Jammu. We have tested
20 RAPD primers, out of them 12 primers were selected for fingerprinting studies. The reaction
was carried out according to Sarwat et al. (2008). The amplification products were scored for the
presence (1) and absence (0) of bands across the genotypes to generate a binary matrix. The
binary matrix was analyzed using the NTSYS-pc to calculate the similarity values and generate
the phenogram. Jaccards similarity coefficient was utilized for estimating the pairwise similarity
.
Ocimum basilicum was found to be closer to Ocimum sanctum. Interspecific study of Ocimum
sanctum further revealed that although, the tulsi samples were taken from different places they
were morphologically and genetically similar depicting that there was not much genetic
diversity.From these plants, SCAR markers can be developed in future. They are highly efficient,
produce sharp and reproducible bands, are economical than other molecular techniques.
Key Words: Molecular Markers, Authentication, Herbal Drugs, AFLP, RAPD, SCAR
National Conference on Drug Discovery and Formulation Development 23rd February 2016
Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus
PO320
THIAZOLIDINE-2, 4-DIONE & ITS ANALOGUES AS ANTICANCER MEDIATED BY
DEPLETION OF INTRACELLULAR CALCIUM: A REVIEW
Karuna S. Shukla*1, Monika
1, Shailendra Pandey
2, Pooja Chawla
3
1 School of Pharmacy, Babu Banarasi Das University, Lucknow
2 Research Lab KAPL Vasai (E) Mumbai
3 Gyani Inder Singh Institute of Professional Studies, Dehradun
Calcium ions plays a crucial role in key biological processes. The major intracellular calcium
store in the endoplasmic reticulum(ER). Depletion of endoplasmic reticulum calcium stores
promote endoplasmic reticulum stress and that leads to the phosphorylation of eukaryotic
initiation factor 2 (eIF2) and thereby inhibition of translation initiation. Translation initiation
plays an important role in regulation of cell proliferation and malignant transformation and is
therefore an attractive target for the development of mechanism specific anticancer drugs.
Thiazolidine-2, 4-dione & its analogues exhibit anticancer properties mediated by inhibition of
translation initiation. These compounds causes partial & sustained depletion of intracellular
calcium stores because they simultaneously release calcium stores. This partial depletion of
intracellular calcium stores causes activation of eIF2 kinases (PKR or/and PERK) leading to the
phosphorylation of the -subunit of eIF2 (eIF2 ) and inhibition of translation initiation and this
leads to the regulation of cell proliferation i.e. anticancer so it is concluded that thiazolidine-2, 4-
dione & its analogues as Anticancer mediated by depletion of intracellular Calcium.
National Conference on Drug Discovery and Formulation Development 23rd February 2016
Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus
PO321
SIMULTANEOUS ESTIMATION OF PIOGLITAZONE AND LOVASTATIN BY RP-
HPLC
Monika1*, Karuna Shanker Shukla
1, Shailendra Pandey
2, Pooja Chawla
3
1School of Pharmacy, Babu Banarasi Das University, Lucknow
2Research Lab. KALP Vasai (E) Mumbai.
3 Gyani Inder Singh Institute of Professional Studies, Dehradun
Email id: [email protected]
Diabetes is a chronic metabolic disorder that prevents the body from utilizing glucose completely
or partially. Obesity is major problem in diabetic patients. Being overweight means increased
insulin resistance. Therefore, Statins are now commonly prescribed for diabetic patients.
Pioglitazone is a thiazolidinedione derivative and it is used in patient with NIDDM. The
probable mechanism of action of Pioglitazone is through the selectively stimulation of nuclear
receptor peroxisome proliferator-activated receptor gamma (PPAR-). Whereas, Lovastatin is an
inhibitor of 3-hydroxy-3-methylglutaryl-coenzymeA reductase, an enzyme that catalyzes the
conversion of HMG-CoA to mevalonate. These drugs are therapeutically used to overcome
serious risk factors associated with cardiovascular diseases. A new simple and precise reverse
phase isocratic high performance liquid chromatography method has been developed for the
determination of Pioglitazone and Lovastatin in formulations. The separation was achieved on
millennium M Sil C18 column using acetonitrile: 20 mM NaH2PO4 (60:40 % v/v) as a mobile
phase and pH was adjusted 3.0 with 5% ortho phosphoric acid. The flow rate was kept at 1
ml/minute, the analytes were screened using UV detector at 230 nm wavelength. The retention
time of Pioglitazone and Lovastatin were found to be 4.1 and 6.5 minutes respectively.
National Conference on Drug Discovery and Formulation Development 23rd February 2016
Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus
PO322
DOUBLE PYLORUS: AN UNCOMMON FEATURE OF STOMACH
Mayank Kulshreshtha*, Manjul Pratap Singh
School of Pharmacy, Babu Banarasi Das University, Lucknow.
Double pylorus (DP) is an uncommon condition consisting of a double communication between
the stomach and the duodenum. DP can occur as either a congenital abnormality or an acquired
complication of peptic ulcer disease. It occurs more often in men (2:1), as well as with other
peptic diseases. The majority of reported cases of double pylorus is acquired and are attributed to
complications of ulcers at the antrum-pyloric area or at the duodenal bulb. Most of them are
consequences of gastric ulcer, and only few cases are due to duodenal ulcer. In this patient, the
previous history of gastric ulcer and the presence of scar tissue at the endoscopic examination
indicated that the lesion are acquired. In diabetes the lack of microcirculation can be the cause.
The majority of the patients respond well to medical treatment, regardless of whether the fistula
is open or closed. However, refractory symptoms can occur in about 20% of the patients, and
surgical treatment is necessary. With the use of potent inhibitors of acid production such as the
proton pump inhibitors, we believe that this number may be reduced. In the clinical setting,
double pylorus can present itself with epigastric pain, dyspeptic symptoms and upper
gastrointestinal bleeding or can be found incidentally.
Key Words: Double pylorus, Duodenal ulcer, Proton pump inhibitors
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Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus
PO323
TRITERPENOIDS: A POTENT HEPATOPROTECTIVE AGENT
1Gunja Srivastava*,
1Manjul Pratap Singh,
2Anurag Mishra
1School of Pharmacy, Babu Banarasi Das University, Lucknow.
2Faculty of Pharmacy, Ashoka Institute of technology and Management, Varanasi.
Liver diseases are a major problem of worldwide proportions, people of nearly every age are
suffering from some or other problem related to liver. Liver damage is very common since
liver has to encounter several toxic substances during their metabolism. To counter with this
loophole there is a demand of such agents that has the capability to fight against such effects.
Due Growing interest in the elucidation of the biological functions of triterpenoids which are
ubiquitously distributed throughout the plant kingdom, they are major component of some
traditional medicinal herbs and traditionally being acclaimed as very potent hepatoprotective
agent. Plants with such constituents have been the remedy of choice for several ethnic
societies that has been subjected to hepatic ailments some or other times. In recent years it
has attracted considerable attention due to its double edged sword effect on liver defined in
terms of prevention and cures both. This review summarizes the beneficial effects of
triterpenoids and is an initiative to establish its identity as effective hepatoprotective agents
and also to explore this moiety to fullest of its extent in the field of research and development
so as to deplete this disease from the society and can be established as a boon for the
medicine industries those generating such hepatoprotective drugs.
National Conference on Drug Discovery and Formulation Development 23rd February 2016
Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus
PO324
CURCUMIN AS A DRUG IN TREATMENT OF ORAL CANCER
Shaista Suhail1*
, Kumud Nigam1, Saurabh Srivastava
2
1Department of Oral Pathology & Microbiology, King Georges Medical University, Lucknow,
UP, India
2Department of Oral & Maxillofacial Surgery, King Georges Medical University, Lucknow, UP,
India
Curcumin (diferuloyl methane), a hydrophobic polyphenol derived from the dietary spice
turmeric. It possesses properties of anti-inflammatory and anti-cancer following oral
administration. It has mechanisms of action including several cell signalling inhibition pathways,
cell cycle (cyclin D1 and cyclin E), apoptosis (activation of caspases and down-regulation of
antiapoptotic gene products), proliferation (HER-2, EGFR, and AP-1), survival (PI3K/AKT
pathway), invasion (MMP-9 and adhesion molecules), angiogenesis (VEGF), metastasis (CXCR-
4) and inflammation (NF-jB, TNF, IL-6, IL-1, COX-2, and 5-LOX), effects on cellular enzymes
such as cyclooxygenase and glutathione S-transferases, 37mmune-modulation. Curcumin also
affects gene transcription mechanism and induce apoptosis in preclinical models. The activity of
curcumin reported against leukemia and lymphoma, gastrointestinal cancers, genitourinary
cancers, breast cancer, ovarian cancer, head and neck squamous cell carcinoma, lung cancer,
melanoma, neurological cancers, oral cancer and sarcoma reflects its ability to affect multiple
targets. Epidemiological and clinical studies have suggested that cancer could be prevented or
significantly reduced by treatment with anti-oxidant and anti-inflammatory drugs, therefore,
curcumin, a principal component of turmeric (a curry spice) showing strong anti-oxidant and
anti-inflammatory activities, might be a potential candidate for the prevention and/or treatment
of oral cancer. Phenolic compound (curcumin) also play an important role as chemopreventive
agents and the development of chemopreventive strategies is an urgent priority in public health.
Cancer is one of life threatening disease of the world. Herb is considered one of the greatest
man-made medicine(drug) which can be easily available and effective. It is the cheapest method
to cure the disease or to prevent it. The herb can be use to make gels, ointments, in tooth paste
etc. for prevention of disease in future. As many technologies are available now a days, it will be
great to make use of this herbs in many ways for prevention or cure of cancer.
National Conference on Drug Discovery and Formulation Development 23rd February 2016
Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus
PO325
FORMULATION AND EVALUATION OF METOPROLOL TARTRATE
MICROSPHERES
M.V. Ramana*1, Kamal Dua
2
1 Amity University, Lucknow, U.P., India
2 School of Pharmacy and Biomedical Sciences, The University of Newcastle, Newcastle,
Callaghan NSW 2308, Australia
Antihypertensive drugs were currently available in the market largely in the form of
conventional dosage forms. There is a need to develop controlled release drug delivery systems
for these categories, so as to optimize the therapy and accrue the benefits enumerated with such
drug delivery systems. One such approach is using polymeric microspheres as drug carriers.
Metoprolol tartrate is rapidly absorbed from both gastric and intestinal regions, after oral
administration.In order to retard the release rate of the metoprolol tartrate, microspheres were
prepared with varying concentrations of a mixture of a water insoluble polymer, ethylcellulose
(EC) and a water-soluble polymer, polyethyleneglycol-6000 (PEG-6000); Table 1. The prepared
microspheres were evaluated for various physicochemical characteristics and in-vitro drug
release.The percent yield of microspheres was in the range 75.2 to 87.3%. A considerable
amount of materials were entrapped into the microspheres (91.0%- 95.7%). This is quite
common with the solvent evaporation method. Particle size of microspheres ranged from 3.27
m to 163.5 m and the average diameter was found to be in the range of 73.2 m to 85.5 m.
FT-IR spectral analysis and DSC concluded the absence of any interaction between the drug and
carriers. The release-time profile of metoprolol tartrate from microspheres in 0.1 N hydrochloric
acid solution was to the extent of 33.4% to 60.2%. The release of metoprolol tartrate from MPT-
3 and MPT-4, in phosphate buffer solution (pH 7.4) was complete within 8 and 7 hours
respectively, whereas incomplete release (72.3%) occurred from MPT-1. Nearly complete
release (98.5%) of metoprolol occurred from MPT-2 in 10 hours, Hence, formulation MPT-2
would be a preferred formulation. The release of metoprolol followed the zero-order kinetics, as
the R2 value was higher for zero-order (R
2 = 0.9642) than for the first-order (R
2 = 0.8260) and
the release mechanism involved is diffusion rate limited (R2 = 0.9865) from microspheres. The
prepared microspheres of metoprolol tartarte eliminate the need for multiple dosing there by
National Conference on Drug Discovery and Formulation Development 23rd February 2016
Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus
increasing patient compliance and decreasing the occurrence of adverse effects by providing a
prolonged release of drug.
PO326
Model-based Drug Development: Applicable to Oncology
Shubham Sharma*, Nimisha Mishra
ASET, Amity University Uttar Pradesh, Lucknow Campus, Lucknow
Model-based drug development (MBDD) is an approach that is used to organize the vast and
complex data streams that feed the drug development pipelines of small molecule and
biotechnology sponsors. Such data streams are ultimately reviewed by the global regulatory
community as evidence of a drugs potential to treat and/or harm patients. Some of this
information is captured in the scientific literature and prescribing compendiums forming the
basis of how new and existing agents will ultimately be administered and further evaluated in the
broader patient community. As this data stream evolves, the details of data qualification, the
assumptions and/or critical decisions based on these data are lost under conventional drug
development paradigms. MBDD relies on the construction of quantitative relationships to
connect data from discrete experiments conducted along the drug development pathway. These
relationships are then used to ask questions relevant at critical development stages, hopefully,
with the understanding that the various scenarios explored represent a path to optimal decision
making. As MBDD becomes more integrated into the pharmaceutical research community, a
more rational explanation for decisions regarding the development of new oncology agents as
well as the proposed treatment regimens that incorporate both new and existing agents can be
expected. Hopefully, the end result is a more focussed clinical development programme, which
ultimately provides a means to optimize individual patient care.
Keywords: clinical pharmacology, model-based drug development, pharmacodynamics,
pharmacokinetics.
National Conference on Drug Discovery and Formulation Development 23rd February 2016
Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus
PO327
EFFECT OF BUXUS WALLICHIANA BAILL EXTRACT AGAINST EXPERIMENTAL
INDUCED AMNESIA IN SWISS ALBINO MICE
Satyendra K Rajput*, Varshala Pal, Arun K Sharma, Shyam Sundar Agrawal
Department of Pharmacology, Amity Institute of Pharmacy, Amity University, Uttar Pradesh,
Sector - 125, Noida, 201303, India.
E-mail: [email protected]
The present study was undertaken to investigate the effect of Buxus wallichiana Baill (wood), on
scopolamine-induced amnesia in mice. Amnesia is the bench mark of Alzheimers diseases
(AD) which would become life threatening at sometime. Male mice were randomized to receive
different dose (125, 250, and 500 mg/kg, p.o) of methanol extract of Buxus wallichiana (MEBW)
for fifteen day against donepezil as reference standard. The Effect on learning and memory was
done using standard memory test includes elevated plus maze (EPM), morris water maze
(MWM), passive avoidance task (PAT). MEBW (125, 250 and 500 mg/kg, p.o) has shown
substantial lessen in transfer latency (TL) in EPM whereas, a significant increase has observed in
step down latency in PAT as compared to scopolamine (1 mg/kg, i.p) treated group. Moreover,
MWM test reveal the mark reduction in escape latency time during training by employing
MEBW (125, 250, 500 mg/kg, p.o). In Probe trial, these animals had spent more time compared
to scopolamine treated group. However these drugs did not alter locomotor activity. It has been
concluded that beneficial effect of MEBW on mice may be attributed to the facilitation of
cholinergic transmission and thereby improvement in memory. Therefore, it would be
worthwhile to explore the therapeutic potential of Buxus wallichiana in the management of
patients with cognitive disorders.
National Conference on Drug Discovery and Formulation Development 23rd February 2016
Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus
PO328
Formulation development & Characterization of Ethosomal gel Approved for the
Treatment of Arthritis
Pratibha Gupta*, Anupum Kumar Sachan
DYANAND DINANATH COLLEGE OF PHRMACY NH# 86, HAMIPUR ROAD, KANPUR-
20914
The present research has been under taken with the aim to develop topical ethosomal gel of
diclofenac by using such as carbopol ,propylene glycol, phospholipid, and soya phosphatidly
choline in different concentration .The oral use of diclofenac is not much recommended as it has
many side effect, thus this gel formulation is made for better patient compliance and reduced the
dose of drug and avoid the side effect like liver& a kidney damage. The different preformulation
studies i.e. Infrared and organoleptic study conforms its purity high moleculer weight ,water
soluble polymer of soya phosphatidly choline ,carbopol 940,phospholipid that possess very high
viscosity ,transparence film forming property at low concentration, gel formulation were
characterized for pH determination ,spreadability & drug release ,drug content ,viscosity
measurement and in vitro drug release .From the study, it was concluded the diclofenac gel
containing carbopol 940 showed good consistencey ,homogencity , spredability & drug release.it
given as wider prospect for the topical preparation .The gel preparation shows excellent
percutaneouse absorption of diclofenac and good characterization.
Key woards: diclofenac, carbopol 940, propylene glycol, drug release.
National Conference on Drug Discovery and Formulation Development 23rd February 2016
Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus
PO329
Nano Particles in Drugs
Mridul Rajeev, Nikhar Shukla, Monika Kamboj, Richa Khare
Amity School of Applied Sciences, Amity University, Lucknow.
Nano particles are very effective in comparison to other one because they are small in size and
can be used anywhere for drug delivery. The main objective of nanoparticles is to control and
manipulate biomacromolecular constructs and supramolecular assemblies that are critical to
living cells in order to improve the quality of human health. By definition, these constructs and
assemblies are nanoscale and include entities such as drugs, proteins, viruses, cellular lipid
bilayers, cellular receptor sites and antibody variable regions critical for immunology and are
involved in events of nanoscale proportions. Therefore nanotherapeutics is the only method
which will allow a deeper understanding of human longevity and human ills that include cancer,
cardiovascular disease and genetic disorders. This is the only technique which provides a wide
range of manmade nanostructures that may be controlled as a function of size, shape and surface
chemistry.
Key words: Biomacromolecular, supramolecular, nanotherapeutics and nanostructures
National Conference on Drug Discovery and Formulation Development 23rd February 2016
Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus
PO330
Role of Biotechnology in Pharmaceuticals
Nikhar Shukla*, Mridul Rajeev, Smriti Khare and Richa Khare
Amity School of Applied Sciences, Amity University, Lucknow
For hundreds of years humankind has used biotechnology in agriculture, food production,
and medicine. Depending on the tools and applications it often overlaps with the fields
of bioengineering, biomedical engineering, bio manufacturing, etc. In recent years, the number
of drugs of biotechnological origin available for many different diseases has increased
exponentially, including different types of cancer, infectious diseases, cardiovascular,
neurological, respiratory and autoimmune diseases. The pharmaceutical industry has used
different technologies to obtain new and promising active ingredients as exemplified by the
fermentation technique, recombinant DNA technique and the hybridoma technique. The
pharmaceutical industry in their attempts to discover new molecules has found annually in the
biotechnology industry with exponential growths. In this paper we reviewed the most important
biopharmaceuticals such as blood factors, hormones, enzymes and vaccines.
Key words: bioengineering, biomedical engineering, bio-manufacturing, Biopharmaceuticals
and hybridoma technique.
National Conference on Drug Discovery and Formulation Development 23rd February 2016
Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus
PO331
Impact of chitosan nanoparticle in drug delivery
Upasana Yadav*
Amity School of Applied Sciences, Amity University, Lucknow-226017, U.P., India
E. Mail:[email protected]
The application of nanotechnology for the treatment, diagnosis, monitoring, and control of
biological systems has recently been determined by the National of Health (NIH) as
nanomedicine. The strategy of Nanoparticle delivery plays a significant impact on global
Pharmaceutical planning and marketing. Polymeric nanoparticles are used to control the drug
release, to improve the dissolution of poorly soluble drugs in addition to improve the
bioavailability of degradable substances such as protein. They also enhance the uptake of
hydrophilic substances across the epithelial layers and have the potential for intracellular drug
delivery. The submicron size range of nanoparticles is not only suitable for parenteral application
but also applicable for mucosal routes of administration, i.e., oral, nasal, and ocular mucosa
which are non-invasive route. Thus nanoparticle formulations are more advantageous over
traditional dosage forms. The main aim of the present review deals with the nanoparticles of
chitosan, which is a natural and bio-degradable polymer. The review focuses on the isolation,
purification, characteristic features derivatives of chitosan, preparation techniques, evaluation
methods and applications of chitosan nanoparticles.
Keywords: chitosan, nanoparticles, bioavailability, biodegradable polymer.
National Conference on Drug Discovery and Formulation Development 23rd February 2016
Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus
PO332
CHEMICAL CONSTITUENTS AND PARTS OF PLANTS AS
IMMUNOMODULATORS
Kalpana Sonwani*, Ashutosh Kumar Yadav
Department of Pharmacology , School of Pharmacy , BBD University , Lucknow
Immunomodulators (IM) are the drugs affecting the immune system. They are used when the
immune response is impaired. Hence to maintain a Disease Free State, modulation of immune
response by either its stimulation or suppression, can be a helpful therapy . Immunodeficiencies
occurs when one or more of the components the immune system are inactive. It included
autoimmunity, hypersensitivity and HIV etc. IM include corticosteroids, cytotoxic agents,
thymosin and immunoglobulins etc. The present review is focused Immunomodulatory effects
of some medicinal plants based on the chemical constituents such as Flavanoids , Alkaloids ,
Phenolic compound , Steroids ,Terpenoids and Tannins present in that particular plant such as
Ficus carica (leaves) ,Aloe vera (Leaves), Cleome gynandra (Aerial parts), Allium sativum
(Whole plant) , Asparagus racemosus ( Root), Tinospora cordifolia (Stem), Ocimum sanctum
(Whole plant) ,Curcuma longa (Balb), Mangifera indica (Stem bark) etc. had been discussed
which are previously explored by the various researchers for their immunomodulatory
activity. As discussed above, it can be conclude that there is a wide scope in herbal drugs and
their formulations in the treatment of immune disorders.
Keywords: Immunomodulators, HIV, Immunodeficiency
National Conference on Drug Discovery and Formulation Development 23rd February 2016
Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus
PO333
CLINICAL BENEFITS OFHERBAL BASED ADAPTOGENS
Pooja Rao*, Dharamveer
Department of Pharmacology, School of Pharmacy, BBD University, Lucknow
Email id:-poojaraoaryan [email protected]
Plant adaptogens are compounds that increase the ability of an organism to adapt to
environmental factorsand to avoid damage from such factors. The beneficial effects of multi dose
administration of adaptogens are mainly associated with the hypothalamicpituitary adrenal
(HPA) axis.Thesingle dose application of adaptogensis important in situations that require a
rapid response to tension or to a stressful situation.In this case, the effects of the adaptogens are
associated with another part of the stresssystem, namely, the sympathoadrenal-system (SAS),
that provides a rapid response mechanism mainly to control the acute reaction of the organism to
a stressor.Theadaptogens like Rhodiolarosea, Schizandrachinensis, Eleutherococcussenticosus
etc showed stimulating effects.The phenolic compounds include phenylpropanoids and
phenylethane derivatives such as salidroside (rhodioloside), rosavin, and lignans are structurally
similar to the catecholaminesthe mediators of the sympatho-adrenal- system (SAS)Recent
pharmacological studies of some adaptogens give a rationale to their effects at the molecular
level. Adaptogens may be regarded as a novel pharmacological category of anti-fatigue agents
that perform the several functions including induce increased attention and endurance in
situations of decreased performance caused by fatigue and/or sensation of weakness and reduce
stress-induced impairments and disorders related to the function of stress (neuro-endocrine and
immune) systems.
National Conference on Drug Discovery and Formulation Development 23rd February 2016
Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus
PO334
ANIMAL MODELS FOR THE STUDY OF STRESS VULNERABILITY RESILIENCE
Richa Mishra*, Ashutosh Kumar Yadav
Department of Pharmacology, School of Pharmacy, BBDUniversity, Lucknow
Resilience is defined as the adaptive maintenance of normal physiology, development and
beha