NANOMED 2017-Tech Digest-Final-R2 · Gwo-Bin Lee received his B.S. and M.S. degrees in Department of Mechanical Engineering from National Taiwan University in 1989 and 1991, respectively

IEEE-NANOMED 2017The 11th IEEE International Conference onNano/Molecular Medicine and Engineering

Shenzhen Virtual University Park ∙ Shenzhen ∙ ChinaDecember 1 - 4, 2017

CONTENTS

Welcome Conference Organizers & CommitteeSponsorsTechnical Program IndexSession SchedulePlenary SessionsKeynote SessionsTechnical SessionsPoster Session

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On behalf ofthe IEEE Nanotechnology Council

& the conference organizingcommittee

We are delighted to welcome you to the 11th

International Conference on Nano/MolecularMedicine & Engineering (IEEE-NANOMED 2017)in December 1 – 4, 2017. Originally laun-ched in2007, IEEE-NANOMED has grown to be one ofthe major international conferences in nano-medicine and nano/molecular engineering andhas brought together world-class engineers,physicians and scientists from all over the worldand every sector of academy and industry,enabling the exchange of the latest advances inbasic and clinical research in the field of nano/molecular medicine and engineering. Prior IEEE-NANOMED conferences were held in Macau(2007), China (Suzhou, 2008), Taiwan (Tainan,2009), Hong Kong (2010), Korea (Jeju, 2011),Thailand (Bangkok, 2012 and Phuket, 2013),Taiwan (Kaohsiung, 2014), USA (Hawaii, 2015),and Macau (2016).

IEEE-NANOMED 2017 is destined to be anotherexciting conference, thanks to the talents anddedication of many volunteers, the invaluableassistance from our stellar professional staffs,and strong support from sponsors. IEEE-NANOMED 2017 is sponsored by the IEEENanotechnology Council, Shenzhen Academyof Robotics, the City University of Hong Kong,the University of Hong Kong, and the Universityof Arkansas. Special gratitude and appreciationis extended to Program Chairs and TechnicalProgram Committee. Without their outstandingwork, we would not have such an excellent andchallenging technical program, which broadlyreaches the field of nano/molecular medicineand engineering and provides a highly inno-vative and informative venue for essential andadvanced scientific and engineering research aswell as translational and clinical research.Thirteen state-of-the-art plenary and keynotepresentations by leading experts, 14 technicalsessions with over +70 invited presentations,and a poster session during our 4-day eventensure an interactive and inspiring exchangebetween participants, making IEEE-NANOMED2017 the right place for new bridges in scienceand knowledge.

We are happy to host IEEE-NANOMED 2017 atShenzhen Virtual University Park in Shenzhen,China. Known as the “Capital of Chinese ThemeParks and Tourism Innovation,” Shenzhen offersmany exciting activities to explore, the better toextend thought provoking and profitable discu-ssions from the formal conference. We wish youa superb conference experience and a memo-rable stay in Shenzhen, China!

Welcome to IEEE-NANOMED 2017!

WELCOME

Ning GU, General ChairSoutheast Univ., China

Jin-Woo KIM, General co-ChairUniv. of Arkansas, USA

Wen J. LI, General co-ChairCity Univ. of Hong Kong, Hong Kong

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CONFERENCE ORGANIZERS & COMMITTEES

STEERING COMMITTEE

Chih-Ming HOUniv. of California, Los Angeles,, USA

Jin-Woo KIMUniv. of Arkansas, USA

Gwo-Bin LEENational Tsing Hua Univ., Taiwan

Wen J. LICity Univ. of Hong Kong, China

Bradley J. NELSONETHZ, Switzerland

Ning XIUniv. of Hong Kong, China

Da-Jeng YAONational Tsing Hua Univ., Taiwan

General Chair

Ning GUSoutheast Univ., China

General Co-Chairs



Program Chair

Lianqing LIUShenyang Institute of Automation, China

Program Co-Chair

In-Kyu PARKChonnam National Univ., Korea

Organizing Chair

Guanglie ZHANG, Shenzhen Academy of Robotics, China

Conference Secretariats

Jeong-Min LIM, Washington Univ., USATracy TSOI, Univ. of Hong Kong, China

Awards Committee Chairs

Edward K. CHOW, National Univ. of Singapore, SingaporeHyun Ho LEE (Chair), Myongji Univ., KoreaDa-Jeng YAO, National Tsing Hua Univ., Taiwan

Publication Chair

Zhidong WANG, Chiba Institute of Technology, Japan

Technical Program Committee

Ting-Hsuan CHEN, City Univ. of Hong Kong, ChinaRussell Deaton, Univ. of Memphis, USAHaewook HAN, Pohang Univ. of Science & Technology, KoreaJacob HENDRICKS, Univ. of Wisconsin, River Fall, USAJangho KIM, Chonnam National Univ., KoreaNalinikanth KOTAGIRI, Univ. of Cincinnati, USAGwo-Bin LEE, National Tsing Hua Univ., TaiwanKin Fong LEI, Chang Gung Univ., TaiwanKi-Taek LIM, Kangwon National Univ., KoreaNa LIU, Shanghai Univ., China

Vellaisamy A.L. ROY, City Univ. of Hong Kong, ChinaJoshua SAKON, Univ. of Arkansas, USAHoon SEONWOO, Sunchon National Univ., KoreaHyuncheol SHIN, State Univ. of New York, KoreaYajing SHEN, City Univ. of Hong Kong, ChinaJianfei SUN, Southeast Univ., ChinaYu SUN, Univ. of Toronto, CanadaSteve TUNG, Univ. of Arkansas, USAPak Kin WONG, Pennsylvania State Univ., USAJohn T.W. YEOW, Univ. of Waterloo, Canada

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CONFERENCE SPONSORS

Institute of Electrical and Electronics Engineering (IEEE)

IEEE Nanotechnology Council (NTC)

Shenzhen Academy of Robotics, Shenzhen, China

City University of Hong Kong, Kowloon Tong, Hong Kong, China

University of Hong Kong, Pok Fu Lam, Hong Kong, China

University of Arkansas, Fayetteville, Arkansas, USA

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TECHNICAL SESSIONS

TECHNICAL PROGRAM INDEX

General Chair

Ning GUSoutheast Univ., China

General Co-Chairs



Program Chair

Lianqing LIUShenyang Institute of Automation, China

Program Co-Chair

In-Kyu PARKChonnam National Univ., Korea

SS1 Bio-Sensing/Microfluidics/NanofluidicsSession Chair: Gwo-Bin LEE, National Tsing Hua Univ., Taiwan

SS2 Intelligent Drug Delivery System and Therapeutical TechnologySession Chair: Ning GU, Southeast Univ., China

SS3 Micro- and Nanotechnologies for Engineering Living SystemsSession Chair: Jangho KIM, Chonnam National Univ., Korea

SS4 New Generation of Multifunctional Bio-Therapeutic NanoparticlesSession Chair: In-Kyu PARK, Chonnam National Univ. Medical School, Korea

SS5 Micro/Nano Devices for Cancer ResearchSession Chair: King Fong LEI, Chang Gung Univ., Taiwan

SS6 Nano/Micro Systems for Biomedical ApplicationsSession Chair: Zhan YANG, Soochow Univ., China

SS7 Bio-Nano MaterialsSession Chair: King Fong LEI, Chang Gung Univ., Taiwan

SS8 Cell Manipulation and 3D Bioprinting for Cancer Detection and Tissue EngineeringSession Chair: Na LIU, Shanghai Univ., China

SS9 Recent Platform Technologies for NanobiosensorSession Chair: Hyun Ho LEE, Myongji Univ., Korea

SS10 Microfluidic System for Biomedical ApplicationsSession Chair: Da-Jeng YAO, National Tsing Hua Univ., Taiwan

SS11 Micro/Nano Robotics for Biomedical ApplicationsSession Chair: Yajing SHEN, City Univ. of Hong Kong, China

SS12 Magnetic Nanomaterials and Tissue EngineeringSession Chair: Ning GU, Southeast Univ., China

SS13 Micro-Engineered Platform for Soft Mattersand Cell ResearchSession Chair: Ting-Hsuan CHEN, City Univ. of Hong Kong, China

SS14 Nano/Bio SensingSession Chair: Vellaisamy A.L. ROY, City Univ. of Hong Kong, China

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IEEE-NANOMED 2017The 11th IEEE International Conference onNano/Molecular Medicine and Engineering

December 1, Friday

Lia Charlton Hotel Shenzhen

12:00-16:00Registration

16:00-17:00Welcome Reception

(for all registered participants)17:00-18:00

December 2, Saturday

Location Demonstration Hall (1/F)

08:30-08:40 Opening Ceremony

08:40-09:30 Plenary Lecture 1: Gwo-Bin LEE“Detection of Bacteria on Microfluidic Systems”

09:30-10:10 Keynote Lecture 1: Haewook HAN“Terahertz Near-Field Microscopy”

10:10-10:30 Coffee Break, Foyer (1/F)

Location Demonstration Hall (1/F) Lecture Theater (2/F) B103 (1/F)

10:30-12:10SS1: Bio-Sensing/

Microfluidics/NanofluidicsChair: Gwo-Bin LEE

SS2: Intelligent Drug Delivery System & Therapeutical Technology

Chair: Ning GU

SS3: Micro- & Nanotechnologies forEngineering Living Systems

Chair: Jangho KIM

12:10-13:00 Lunch (for all registered participants)

13:00-13:50 Plenary Lecture 2: Noo Li JEON“3D Microfluidic Platform for Organ on a Chip Applications and Beyond”

13:50-14:30 Keynote Lecture 2: Da-Jeng YAO“Microfluidic Reproductive Medicine on a Chip”


14:50-16:30 SS4: New Generation of Multifunctional Bio-

Therapeutic Nanoparticles Chair: In-Kyu PARK

SS5: Micro/Nano Devices for Cancer Research Chair: Kin Fong LEI SS6: Nano/Micro Systems for

Biomedical Applications Chair: Zhan YANG

16:30-18:10 SS7: Bio-Nano Materials Chair: Kin Fong LEI

SS8: Cell Manipulation & 3D Bioprinting for Cancer Detection

& Tissue Engineering Chair: Na LIU

19:30-22:00 Organizers’ Dinner (by Invitation Only)

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Chair: Jin-Woo KIM

IEEE-NANOMED 2017December 3, Sunday


08:30-09:20 Plenary Lecture 3: Tony Jun HUANG“Acoustofluidics: Merging Acoustics and Microfluidics for Biomedical Applications”

Poster Session at Foyer(1/F)

09:20-10:10 Plenary Lecture 4: John T.W. YEOW“Micro/Nano Biomedical Imaging Devices”


10:30-11:20 Plenary Lecture 5: Yu SUN“Robotic Cell Manipulation: Surgery, Diagnostics, and Drug Screen”

11:20-12:00Keynote Lecture 3: Pak Kin WONG

“A Microfluidic Platform forSingle Cell Antimicrobial Susceptibility Testing and Pathogen Identification”

12:00-13:00 Lunch (for all registered participants)

13:00-13:40 Keynote Lecture 4: Edward K.-H. CHOW“Drug-Delivery and Imaging Applications of Nanodiamonds”

13:40-14:20 Keynote Lecture 5: In-Kyu PARK“Multi-Stimuli Regulated Nano-Micelles for Tumor-Targeted Therapy”



15:00-17:00 SS9: Recent Platform Technologies for Nanobiosensor Chair: Hyun Ho LEE

SS10: Microfluidic System for Biomedical Applications

Chair: Da-Jeng YAO

SS11: Micro/Nano Robotics for Biomedical Applications

Chair: Yajing SHEN

18:00-22:00 Conference Banquet (for all registered participants)

December 4, Monday


08:30-09:20 Plenary Lecture 6: Larry A. NAGAHARA“Nanotechnologies in Healthcare: Current Challenges and Future Prospects”

09:20-10:10 Plenary Lecture 7: Chih-Ming HO“Small Data or Big Data for Personalized Medicine?”


10:30-11:20 Plenary Lecture 8: Mingjun ZHANG“Photo-activated Peptide Nanoparticles for Cancer Therapy and Alzheimer’s Disease Diagnosis”

11:20-11:30 Break


11:30-13:10SS12: Magnetic Nanomaterials & Tissue Engineering Chair: Ning GU

SS13: Micro-engineered Platform for Soft Matters and Cell Research

Chair: Ting-Hsuan CHEN

SS14: Nano/Bio Sensing Chair: Vellaisamy A.L. ROY

14:00-16:00 Farewell Reception (for all registered participants)

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The 11th IEEE International Conference onNano/Molecular Medicine and Engineering

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Chair: Jin-Woo KIM

Chair: Jin-Woo KIM

Chair: Wen J. LI

Chair: Wen J. LI

Chair: Lianqing LIU

Chair: Lianqing LIU

Chair: Wen J. LI

Chair: Wen J. LI

Chair: Jin-Woo KIM

IEEE-NANOMED PLENARY

Detectionofbacteriaonmicrofluidicsystems

Gwo-Bin LEE

Chair Professor of National Tsing Hua UniversityDepartment of Power Mechanical Engineering

Institute of Biomedical EngineeringInstitute of NanoEngineering and Microsystems

National Tsing Hua University, Taiwan

PL1: 08:40 – 09:30Saturday, December 2, 2017Location: Demonstration Hall, 1/F

Abstract

In this talk, he will briefly introduce several research works in my group using integrated microfluidic systems for detection ofbacteria. For bacterial detection, we can now answer the following questions:

• Was it infected by bacteria?• What kind of bacteria caused the infection?• Arebacteria alive or dead?• Arebacteria antibiotics-resistant?• What kind of antibiotics and dose could cure this bacterial infection?

Short Bio

Gwo-Bin Lee received his B.S. and M.S. degrees in Department of Mechanical Engineering from National Taiwan University in1989 and 1991, respectively. He received his Ph.D. in Mechanical & Aerospace Engineering from University of California, LosAngeles, USA in 1998. Dr. Gwo-Bin LEE is currently a Chair Professor in the Department of Power Mechanical Engineering atNational Tsing Hua University. His research interests lie on nano-biotechnology, micro/nanofluidics and their biomedicalapplications. He is the directors of “MEMS Design and Microfabrication Lab” and “Microfluidic Biochips Lab”. Dr. LEE has beenvery active in the field of micro/nanofluidic systems, and has developed integrated micro/nano systems incorporated withnano/biotechnology for biomedical applications. He has developed several micro/nano-scale platforms for cell, protein, andDNA manipulation and detection. Dr. LEE has published over 272 SCI journal papers, 384 conference papers, and filed 147patents (101 patents granted) in the past 19 years. His works have been highly cited (over 7200 times) with an H-index of 46(ISI). In Google Scholar, citations of all Dr. LEE’s papers are 12000 times with an h-index of 60. He also published 8 bookchapters. He has served as a technical or organizing committee member in many international conferences. He was GeneralCo-chair of IEEE NEMS 2014, IEEE MEMS 2013, IEEE NANOMED 2013, and General chair of IEEE NEMS 2011. He hasreceived several academic awards, including Dragon Thesis Award (2002), Distinguished Research Award from EngineeringSchool of National Cheng Kung University (2002), Distinguished Young Engineer Award from Chinese Engineering Society(2003), K. T. Lee Research Award from K. T. Lee Foundation (2004), Distinguished Mechanical Engineer Award from ChineseMechanical Engineering Society (2004), Distinguished Young Electrical Engineer Award from Chinese Electrical EngineeringSociety (2005), Young People of the Year (2006), Distinguished Engineering Professor from Chinese Mechanical EngineeringSociety (2006), Engineering Professor Award from Southern Division of Chinese Engineering Society (2007), Excellent ResearchAward from National Science Council in Taiwan (2007, 2011, 2014), National Innovation Award (2008, 2010, 2012, 2013,2016), Distinguished Engineering Professor Award from Chinese Engineering Society (2009), Distinguished Kuo-Ting LEEResearcher Award from Kuo-Ting LEE Foundation (2009), and Outstanding Inventor Award (2011). He is the Fellow of Societyof Theoretical and Applied Mechanics and the Fellow of Chinese Society of Mechanical Engineering. He was an elected ASMEFellow in 2013, an elected RSC Fellow in 2014, elected IET Fellow in 2015, and elected IEEE Fellow in 2016. He has beeninvited in various conferences for plenary and keynote talks. Currently, he is joint Editor-in-chief of Micro and Nano Lettersand editor of several journals, including Scientific Reports, IET Bionanotechnology, Micro and Nanosystem, Microfluidics andNanofluidics and Recent Patents on Nanotechnology. He is also a member of advisory board in Lab on a chip journal. He wasthe chair of International Steering Committee of IEEE MEMS 2015.

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Noo Li JEON

ProfessorSchool of Mechanical and Aerospace Engineering

Seoul National University, Korea


Abstract

This presentation will describe the development of 3D microfluidic platform for vascularized organ on a chip applications.Applications of the vascular platform for modeling eye, skin, and bone will be described. Recent development of injectionmolded device for high throughput drug screening will also be described.

Short Bio

Noo Li Jeon obtained his Ph.D. degree in Materials Science and Engineering from the University of Illinois, Urbana-Champagnein 1997 under Prof. Ralph G. Nuzzo. After postdoctoral research in Prof. George M. Whitesides’ laboratory at HarvardUniversity working on soft lithography related projects and microfluidic devices, he spent a year in Prof Mehmet Toner’slaboratory at Harvard Medical School working on neutrophil chemotaxis in microfluidic devices. From 2001 to 2009, he was anAssistant and Associate Professor in the Department of Biomedical Engineering at University of California, Irvine. He joined theSchool of Mechanical and Aerospace Engineering at Seoul National University in 2009. His current research interest spansbiomedical engineering, materials science, and mechanical engineering.

3DMicrofluidicplatformfororganonachipapplicationandbeyond

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Tony Jun HUANG

ProfessorMechanical Engineering and Materials Science

Pratt School of EngineeringDuke University, USA

PL3: 08:30 – 09:20Sunday, December 3, 2017Location: Demonstration Hall, 1/F

Abstract

The past two decades have witnessed an explosion in lab-on-a-chip research with applications in biology, chemistry, andmedicine. The continuous fusion of novel properties of physics into microfluidic environments has enabled the rapiddevelopment of this field. Recently, a new lab-on-a-chip frontier has emerged, joining acoustics with microfluidics, termedacoustofluidics. Here we summarize our recent progress in this exciting field and show the depth and breadth of acoustofluidictools for biomedical applications through many unique examples, from exosome separation to cell-cell communications to 3Dbioprinting, from circulating tumor cell isolation and detection to ultra-high-throughput blood cell separation for therapeutics,from high-precision micro-flow cytometry to portable yet powerful fluid manipulation systems. These acoustofluidictechnologies are capable of delivering high-precision, high-throughput, and high-efficiency cell/particle/fluid manipulation in asimple, inexpensive, cell-phone-sized device. More importantly, the acoustic power intensity and frequency used in theseacoustofluidic devices are in a similar range as those used in ultrasonic imaging, which has proven to be extremely safe forhealth monitoring during various stages of pregnancy. As a result, these methods are extremely biocompatible; i.e., cells andother biospecimen can maintain their natural states without any adverse effects from the acoustic manipulation process. Withthese unique advantages, acoustofluidic technologies meet a crucial need for highly accurate and amenable disease diagnosis(e.g., early cancer detection and prenatal health) as well as effective therapy (e.g., transfusion and immunotherapy).

Short Bio

Tony Jun Huang is a professor at Department of Mechanical Engineering and Materials Science (MEMS) at Duke University.Previously he was a professor and The Huck Distinguished Chair in Bioengineering Science and Mechanics at The PennsylvaniaState University. He received his Ph.D. degree in Mechanical and Aerospace Engineering from the University of California, LosAngeles (UCLA) in 2005. His research interests are in the fields of acoustofluidics, optofluidics, and micro/nano systems forbiomedical diagnostics and therapeutics. He has authored/co-authored over 180 peer-reviewed journal publications in thesefields. His journal articles have been cited more than 11,000 times, as documented at Google Scholar (h-index: 58). He also has19 patents and invention disclosures. He was elected a fellow of the following five professional societies: the American Institutefor Medical and Biological Engineering (AIMBE), the American Society of Mechanical Engineers (ASME), the Institute of Electricaland Electronics Engineers (IEEE), the Institute of Physics (IOP), and the Royal Society of Chemistry (RSC). Huang’s research hasgained international recognition through numerous prestigious awards and honors including a 2010 National Institutes ofHealth (NIH) Director’s New Innovator Award, a 2012 Outstanding Young Manufacturing Engineer Award from the Society forManufacturing Engineering, a 2013 American Asthma Foundation (AAF) Scholar Award, JALA Top Ten Breakthroughs of theYear Award in 2011, 2013, and 2016, the 2014 IEEE Sensors Council Technical Achievement Award from the Institute ofElectrical and Electronics Engineers (IEEE), and the 2017 Analytical Chemistry Young Innovator Award from the AmericanChemical Society (ACS).

Acoustofluidics:mergingacousticsandmicrofluidicsforbiomedicalapplications

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Micro/nano biomedicalimagingdevices

John T.W. YEOW

Professor and Canada Research Chair in Micro/Nano DevicesDepartment of Systems Design Engineering

University of Waterloo, Canada


Abstract

The emergence of minimally invasive diagnostics and therapeutics in modern high-tech medicine has generated an unmetdemand in miniaturized biomedical devices. There exists a definite need for clinical diagnostic and treatment instruments thatare based on micro and nanotechnologies. In the past decade, micromachining technology and nanomaterials are making bigimpacts in many fields, especially in the field of biomedical engineering. The small size and low mass provided bymicro/nanodevices make medical instruments portable, power efficient, and, in many cases, more effective. This talk will focuson the current development of the state-of-the-art miniaturized X-ray CT machines, and ultrasound imaging devices.

Short Bio

John T.W. Yeow received the B.A.Sc. degree in electrical and computer engineering, and M.A.Sc. and PhD. degrees inmechanical and industrial engineering from the University of Toronto, Toronto, ON, Canada. He is currently a Professor in theDepartment of Systems Design Engineering at University of Waterloo, Waterloo, ON, Canada. His current research interestsare in the field of developing miniaturized biomedical instruments. He is a recipient of the Professional Engineering OntarioYoung Engineer Medal, Professional Engineering Ontario Engineering Excellence Award, Natural Science & EngineeringResearch Canada Innovation Challenge Award, Douglas R. Colton’s Medal of Research Excellence, Micralyne MicrosystemsDesign Award, Ontario Ministry of Research and Innovation’s Early Researcher Award, and University of Toronto AlumniAssociation 7T6 Early Career Award. He is a Canada Research Chair in Micro/Nanodevices. He is the Editor-in-Chief of theIEEE Nanotechnology Magazine, an Associate Editor of the IEEE Transactions of Nanotechnology, and a member of theEditorial Board of Scientific Reports (Nature Publishing Group). He is a Fellow of the Engineering Institute of Canada, and aMember of College of New Scholars, Artists and Scientists of the Royal Society of Canada. He is also a 2017 IEEENanotechnology Technical Council Distinguished Lecturer.



Roboticcellmanipulation:surgery,diagnostics,anddrugscreen

Yu SUN

Professor andCanada Research Chair in Micro and Nano Engineering Systems

Department of Mechanical and Industrial EngineeringInstitute of Biomaterials and Biomedical EngineeringDepartment of Electrical and Computer Engineering

University of Toronto, Canada

PL5: 10:30 – 11:20Sunday, December 3, 2017Location: Demonstration Hall, 1/F

Abstract

Advances in medicine demand robotic technologies for automated manipulation and characterization of cells and sub-cellularstructures. Robotic cell surgery and automated characterization of cells enable new frontiers in medicine. Robotic deposition offoreign materials into cells is poised to revolutionize drug efficacy tests for drug repurposing and personalized medication. Inthis talk, I will first provide an overview of recent progress in medical micro-nanorobotics. Technical challenges in robotic cellmanipulation will then be introduced. Next, I will summarize recent progress in clinical trial of our robotic cell surgerytechnology. I will then present robotic characterization of voided urine cells to bolster clinical bladder cancer diagnostics. Drugscreen for cardiovascular disease management, enabled by robotic cell manipulation, will also be discussed. I will end the talk bysharing recent activities that shift the paradigm of robotic cell manipulation from single-cell manipulation to intracellularnavigation and measurement.

Short Bio

Yu Sun is a Professor in the Department of Mechanical and Industrial Engineering, with joint appointments in the Institute ofBiomaterials and Biomedical Engineering and the Department of Electrical and Computer Engineering at the University ofToronto. He was elected Fellow of ASME (American Society of Mechanical Engineers), IEEE (Institute of Electrical andElectronics Engineers), AAAS (American Association for the Advancement of Science), and CAE (Canadian Academy ofEngineering) for his work on micro-nano devices and robotic systems. He obtained his Ph.D. from the University of Minnesotain 2003 and did his postdoctoral research at ETH-Zürich. He is presently a McLean Senior Faculty Fellow at the University ofToronto and the Canada Research Chair in Micro and Nano Engineering Systems. In 2012-2013, he directed the University ofToronto Nanofabrication Center. Sun has served and serves on the editorial boards of several IEEE Transactions, J.Micromechanics Microengineering, Scientific Reports, and Microsystems & Nanoengineering. Among the awards, he receivedwere a dozen best paper awards and finalists at major conferences; five times University of Toronto Connaught InnovationAward; Inventor of the Year Award; the McLean Award; the First Prize in Technical Achievement of ASRM (American Societyfor Reproductive Medicine); and an NSERC E.W.R. Steacie Memorial Fellowship.



Larry A. NAGAHARA

ProfessorWhiting School of Engineering

Johns Hopkins University, USA

PL6: 08:30 – 09:20Monday, December 4, 2017Location: Demonstration Hall, 1/F

Abstract

Nanotechnology has the potential to transform healthcare in profound ways. Combined with personalized medicine, one ofthe promises for nanomedicine is a scenario where an individual diagnosed with a disease will be able to receive the righttreatment (i.e., right time and right dose) tailored for that specific individual’s medical need through the use ofnanotechnology. Being able to realize this scenario may take some time. While stunning progress in the molecular sciencesand other advanced technologies has been made over the past several decades, the complex interplay of genomics andenvironmental factors for many common diseases, such as cancer, has inhibited substantial improvement in the treatment ofthese disease This presentation will describe in details some of the recent advances in nanotechnology to address majorquestions and barriers in biomedical research and the challenges that nanotechnology faces in integration into healthcare.

Short Bio

Larry A. Nagahara is the Associate Dean for Research in the Whiting School of Engineering as well as a Research Professor inthe Department of Chemical and Biomolecular Engineering at Johns Hopkins University. Previously, he was an AssociateDirector within the Division of Cancer Biology at National Cancer Institute (NCI)/National Institutes of Health (NIH), wherehe directed and coordinated programs and research activities related to expanding the role of the physical sciences andengineering in cancer research. Before joining NCI, Dr. Nagahara was a Distinguished Member of the Technical Staff atMotorola and led their nanosensor effort. He has published over 95 technical papers, 3 book chapters, and over 25 patentsissued/filed in these fields. He is a Fellow of the American Association for the Advancement of Science (AAAS), AmericanInstitute for Medical and Biological Engineering (AIMBE), American Physical Society (APS), IEEE, and a former member ofMotorola’s Scientific Advisory Board.

Nanotechnologiesinhealthcare:Currentchallengesandfutureprospects



Smalldataorbigdataforpersonalizedmedicine?

Chih-Ming HO

ProfessorHenry Samueli School of Engineering and Applied Science

University of California, Los Angeles, USA


Abstract

How do we guide a specific patient’s body through efficient and safe therapy toward a desired phenotype for improving health?Applying omic approach for personalized medicine in fact faces almost an infinite database. In addition, omic approach cannotprovide quantitative information, e.g. dose, and cannot scale up to tissue, organ and body levels.

Recently, we have discovered that the drug-dose inputs are correlated with the phenotypic outputs with a Parabolic ResponseSurface (PRS). With a few calibration tests to determine the coefficients of the quadratic algebraic equation governing PRS, PRSis able to dictate the composition and the ratio of a globally optimized drug combination for treating disease.

The PRS platform has been validated in in vitro, preclinical and clinical tests. In addition, PRS based Phenotypic PersonalizedMedicine (PPM) can realize unprecedented levels of adaptability to identify the optimized drug combination for a specificpatient. Furthermore, PRS is an indication agnostic platform technology, which has been successfully demonstrated in about 25diseases for children and adults. By taking an unorthodox approach of bypassing the omic networks, the discovery of aParabolic Response Surface (PRS) can redefine the drug discovery pathway.

Short Bio

Chih-Ming Ho is a Distinguished Research Professor in UCLA School of Engineering. His research interest is in control ofcomplex systems including personalized medicine, microfluidics, biosensor and turbulence. In 1997, Dr. Ho was inducted as amember of the US National Academy of Engineering. In the next year, he was elected as an Academician of Academia Sinica.Dr. Ho received Doctor of Engineering Honoris Causa from Hong Kong University of Science and Technology. Dr. Ho holdsten honorary chair professorships including the Einstein Professorship from Chinese Academy of Science. Dr. Ho is Fellow ofAAAS, APS, AIAA, AIMBE and 3M-Nano Society.



Mingjun ZHANG

ProfessorDepartment of Biomedical Engineering

Department of SurgeryDepartment of Electrical and Computer Engineering

Davis Heart and Lung Research InstituteNeurological InstituteBiophysics Program

Center for Regenerative Medicine and Cell Based TherapiesOhio State University, USA


Abstract

Cancer is one of the major causes of death, and Alzheimer’s disease (AD) has the highest growing rate of causes for death inrecent years. One of the major challenges for treating and diagnosing these diseases is the lack of externally controllablechemical reagents for targeting and imaging of disease molecules. Self-assembled short peptide nanoparticles hold great promisefor targeting and imaging of biomolecules in vivo, as they are inherently biocompatible and can be easily modified to interfacewith biomolecules. This talk will present our recent research results on developing photo-activated peptide nanoparticles forcancer therapy and AD diagnosis. We will discuss 1) how a new class of photo-activated peptide nanoparticles can be self-assembled by using the 20 standard natural amino acids to shift light from ultraviolet to visible and near infrared range; 2) howa new type of photoactivated cyclic peptide nanoparticles can be tethered with tumor homing moieties and serve as a vehiclefor targeted delivery of therapeutic reagents; and 3) how the peptide nanoparticles may be used for detecting Aβ aggregationsin blood samples, which can be further employed for early noninvasive detection of AD. All the above peptide nanoparticlescan be photo-activated for imaging and targeting, so that they can be used for selective and sensitive imaging and detection ofdisease molecules.

Short Bio

Mingjun Zhang is a Professor in the Departments of Biomedical Engineering and Surgery (courtesy), Neurological Institute andDavis Heart and Lung Institute at The Ohio State University. He received the Doctor of Science degree in Systems Science andMathematics from Washington University in St. Louis, and the PhD degree in Industrial Automation from Zhejiang University.He also holds MS degrees in Electrical Engineering and Bioengineering respectively from Stanford University. His BS/MS degreeswere in Mechanical from Zhejiang University. He first discovered that ivy secretes nanoparticles for surface affixing (Nano Lett,2008). In 2011, his group discovered a unique multi-flagella-based swimming mechanism of Giardia (PNAS) that has beeproposed for micro/nano-robotic propulsion. In 2012, his group discovered the curved swimming trajectories of whirligigbeetles are more energy efficient than linear trajectories, which explains why they are more often observed in nature (PLoSComp. Bio.). In 2013, his group discovered nanoparticles secreted from a carnivorous fungus could be used forimmunochemotherapy (Adv. Func. Mater.). In 2014, his group discovered that T. foetus has distinct flagellar beating motions forlinear swimming and turning, and multiflagellated propulsion does not necessarily contribute to greater thrust generation, andmay have evolved for greater maneuverability or sensing (J. Roy. Soc., Inter.). In 2016, his group self-assembled firstGFP/YFP/BFP-inspired fluorescent peptide nanoparticle shifting ultraviolet light to visible range (Nature Nanotechnology). In2017, his research group discovered a new class of “physical biomarkers” for Alzheimer’s disease, and developed acomputational algorithm to integrate the biomarkers and cognitive assessments to diagnose AD and predict its progression(Science Advances). His long-term research goal is to create a library of functional nanoparticles and used them as buildingblocks for sensing, actuation and control in medicine and robotics. Mingjun’s research has been sponsored by NSF, ARO, AFRL,ONR, ORNL, National Academies’ Keck Future Initiative, Mangurian Foundation, Ross Center for Brain Health andPerformance and industries. Research results from his laboratory were highlighted by Science, Nature, AAAS Science, BBCnews, Alzheimer’s News, American Chemical Society, Royal Society of Chemistry, Biomedical Engineering Society, and theNational Science Foundation of USA. He was awarded Early Career Awards by IEEE Robotics and Automation Society, and theOffice of Naval Research. He has 7 years biotechnology industry working experience in Silicon Valley, California, USA.

Photo-activatedpeptidenanoparticlesforcancertherapyandAlzheimer’sdiseasediagnosis


IEEE-NANOMED KEYNOTES

Terahertznear-fieldmicroscopy

Haewook HANDepartment of Electrical Engineering

Pohang University of Science and Technology (POSTECH)Pohang, Korea

KN1: 09:30 – 10:10Saturday, December 2, 2017Location: Demonstration Hall, 1/F

Abstract

Terahertz time-domain spectroscopy (THz-TDS) has recently beena powerful tool for probing fundamental low-energy dynamicprocesses in solid-state and biological materials. Understanding suchlow-energy THz dynamics has become crucial for developing next-generation electronic and optical devices. To realize THz-TDS withsubwavelength resolution, various types of near-field imagingtechniques have been combined with THz-TDS. At present,scattering-type scanning near-field optical microscopy (s-SNOM)seems to be the most viable technique that can offer nanoscaleresolution and broadband THz spectroscopy simultaneously. In thiswork, we report a THz s-SNOM system that has recently beendeveloped by combining a tapping-mode atomic force microscope(AFM) and a conventional THz-TDS system. Combined with THz-TDS, THz near-field microscopy based on an atomic forcemicroscope is a technique that, while challenging to implement, isinvaluable for probing low-energy light-matter interactions of solid-state and biomolecular nanostructures, which are usually embeddedin background media. We experimentally demonstrate a broadbandTHz pulse near-field microscope that provides subsurfacenanoimaging with a nearly frequency-independent lateral resolutionof 90 nm, corresponding to ∼λ/3300 at 1 THz.

Short Bio

Haewook Han is the Director of Nano-Bio THz PhotonicsLaboratory, Department of Electrical Engineering, POSTECH,Korea. He was also the Directors of the Center for THzPhotonics (1998-2000) and the National Laboratory for Nano-THz Photonics (2005-2009), both funded by the Korean Ministryof Science and Technology. He received B.S. and M.S. degrees inElectrical Engineering from Seoul National University, Korea in1986 and 1988, respectively, and Ph.D. degree in ElectricalEngineering from Prof. Coleman’s group at the University ofIllinois at Urbana-Champaign (UIUC), Urbana, USA in 1995, wherehe studied advanced semiconductor lasers: strained quantum-well(QW) lasers and two-dimensional photonic crystal lasers. At BellLaboratories, Murray Hill from 1995 to 1997, he developed high-power high-speed (up to 20 GHz) strained QW lasers. Afterjoining the faculty of POSTECH, he has been pursuinginterdisciplinary research on Nano-Bio THz Photonics. Hiscurrent research focuses on THz spectroscopy of biomolecularsystems and quantum matters, THz spectroscopic near-fieldnanoscopes, and THz biomolecular devices. He founded theKorea THz Forum and the THz-Bio Quantum Forum in 2008 and2011, respectively. He has served as Program Chairs for many


international conferences, including the International Conferenceon Infrared, Millimeter, and Terahertz Waves (2009) and theInternational THz-Bio Workshop (2010-2016). He is currently theAssociate Editors of the IEEE Transactions on Nanotechnology.

…….Microfluidicreproductivemedicineonachip

Da-Jeng YAODepartment of Power Mechanical Engineering

Institute of NanoEngineering and MicroSystemsDepartment of Engineering and System Science

National Tsing Hua University, Taiwan

KN2: 13:50 – 14:30Saturday, December 2, 2017Location: Demonstration Hall, 1/F

Abstract

The in vitro fertilization (IVF) is an important technique in biologicaland clinical studies since 1970. In recent years, microfluidic systemhas been widely used in cell detection or position a single-cell level,including the mechanical, optical, electromagnetic fields due to theadvantages of biocompatibility, high-precision, low-cost, disposable,and easy to reproduce, etc. In this presentation, we propose threedifferent types of microfluidic systems, the imitation oviductmicrofluidic chips, to enhance the probability of embryo fertilizationfor Oligozoospermia patients.At the first of the continued microfluidic chip, the motile sperms

from the oligozoospermia patients can be separated by usingmicrofluidic chip based on its laminar flow. Then to imitate theoviduct, the oocyte can be effectively position by dielectrophoresis(DEP) technology, and it will be reacted with those motile sperms toform embryo under proper cultural environment. Finally, thereacted oocyte, embryo, was moved to incubator for furtherculture. The embryo can be cultured successfully after three and anhalf day, that is comparable with the one by using traditional IVF.In contract with continued microfluidic system, two types of

droplet-based microfluidic system would be presented. The dynamicculture is demonstrated with a system for EWOD that canmanipulate a single droplet containing one mouse embryo to mimicthe path from an oviduct to a uterus. A static mouse embryo cultureon EWOD chips is presented for comparison with the results ofdynamic culture. According to the dynamic and static results, therate of embryo cleavage to hatching blastocyst with a dynamicculture is greater than that with a static culture. The EWOD systemcan enhance the culture of mouse embryos in a dynamicenvironment.Another droplet-based microfluidic system will also beshown, not just only for the embryo droplet formation from spermsand oocyte, but further for dynamic culture in the microchannel.

Short Bio

Da-Jeng YAO is a Professor at Department of Power MechanicalEngineering and Institute of NanoEngineering and MicroSystems


Amicrofluidicplatformforsinglecellantimicrobialsusceptibilitytestingandpathogenidentification

Abstract

Acute bacterial infections are a major cause of patient morbidityand represent a significant burden of the healthcare system.Accurate and timely pathogen diagnostics will improve the clinicalmanagement of infectious diseases. Pathogen detection andantimicrobial susceptibility testing (AST) are performed on patientsamples, such as blood, urine, and wound swabs, to detectpathogens and their resistances. Conventional culture-basedanalysis, however, requires at least 2–3 days for bacterial growthand could be much longer for slow-growing bacteria. The lack of arapid diagnostic method, in turn, drives the improper use ofbroad-spectrum antibiotics, which accelerates the emergence ofantimicrobial resistance in pathogens. Therefore, rapid AST andpathogen identification represent key technological hurdles inmanaging infectious diseases and combating multidrug-resistantpathogens. To address the hurdles, my laboratory establishes atunable microfluidic device that traps bacteria according to theirphysical size for bacteria categorization and AST in as little as 30minutes. We have also developed a nanobiosensor for rapidpathogen identification at the single cell level. We demonstrate theclinical applicability of the techniques by urine and blood samplesfrom patients with infection.

KN3: 11:20 – 12:00Sunday, December 3, 2017Location: Demonstration Hall, 1/F

Pak Kin WONG

Department of Biomedical EngineeringDepartment of Mechanical Engineering

Pennsylvania State University, USA

…….Drugdeliveryandimagingapplicationsofnanodiamonds

Edward Kai-Hua CHOWCancer Science Institute of Singapore

National University of Singapore, Singapore


Abstract

Nanodiamonds (NDs) are ~4nm carbon nanoparticles with atruncated octahedral structure. Due to their unique chemicalproperties, nanodiamonds are versatile drug deliverynanomaterials that can be functionalized with a broad array ofmolecules, including small molecules, proteins and genetic material.Furthermore, their size, chemical composition and structureconfer a high level of biocompatibility. While numerous studieshave demonstrated a diversity of molecular payloads that can bedelivered by nanodiamonds, we will discuss specific drug deliveryand imaging applications where nanodiamonds have shown distinctimprovements over standard methods. In particular, nanodiaondsare powerful tools for improving diagnosis and treatment ofcancer. This includes the development of nanodiamond-basedanthracycline delivery complexes that are more effective and saferthan clinical standards. We will also discuss the efforts andprogress that has been made to translate preclinical work onnanodiamond-anthracyclines into the clinic. Unique chemical;properties of nanodiamonds also lend these nanomaterialstowards imaging applications. We will discuss some of theseimaging modalities, with particular emphasis on how nanodiamond


(NEMS), also an adjunct Professor at Department of EngineeringSystem and Science, National Tsing Hua University, Taiwan. Hereceived his MS from Department of Mechanical Engineering,Lehigh University in 1996, and Ph.D. from Department ofMechanical and Aerospace Engineering, University of California atLos Angeles (UCLA) in 2001. His research can be divided into fourcategories: Bio-sensing system, including proteins detection, DNAsequencing recognition, and intelligent gas sensing system; Multi-electrode arrays for brain research; EWOD (Electrowetting onDielectrics) on microfluidic system; and Microfluidic ReproductiveMedicine on a chip. He got Wu-Da-Yu Memorial Award (YoungInvestigator) from National Science Council in 2009, Shen-Yinaward in 2010, Young Researcher from Society of Theoretical andApplied Mechanics of the Republic of China in 2012, NationalInnovation Award in both 2012 and 2014, and NanoscienceAward by Publishing Division of Cognizure in 2015. He wasawarded as ASME fellow since 2013.

…….

Short Bio

Pak Kin Wong is a Professor of Biomedical Engineering,Mechanical Engineering, and Surgery at the Pennsylvania StateUniversity. Prior to Penn State, Dr. Wong was a faculty in theDepartments of Aerospace and Mechanical Engineering andBiomedical Engineering at the University of Arizona. He receivedhis Ph.D. from the University of California, Los Angeles in 2005.Dr. Wong’s research focuses on bioengineering techniques forelucidating collective cell migration in tissue regeneration andcancer metastasis, and developing microfluidic systems for medicaldiagnostics. He has published over 90 peer-reviewed journalarticles in the area of nanotechnology and biomedical engineering,and is an inventor of three patents. He is an editor of ScientificReports, IEEE Transaction on Nanotechnology, IEEENanotechnology Magazine, and SLAS Technology. Among otherhonors, Dr. Wong received the NIH Director’s New InnovatorAward in 2010, Arizona Engineering Faculty Fellow in 2011,AAFSAA outstanding Faculty Award in 2013, and JALA 10 – ATop 10 Breakthrough in Innovation in 2015.Dr. Wong is a Fellowof Royal Society of Chemistry (RSC), American Institute ofMedical and Biological Engineering (AIMBE), and Society forLaboratory Automation and Screening (SLAS).


Short Bio

Edward Kai-Hua Chow is an Assistant Professor at NationalUniversity of Singapore (NUS) in the Cancer ScienceInstitute of Singapore and the Department of Pharmacology.His research group is interested in understanding howspecific genomic alterations affect cancer progression andhow this information can be applied towards engineering-based approaches to improve combinatorial drug deliveryand cancer imaging. He received his B.A. in Molecular andCellular Biology with an Immunology emphasis from theUniversity of California Berkeley. Under the mentorship ofProf. Genhong Cheng at University of California Los Angeles,he earned his Ph.D. identifying key molecular pathwaycrosstalk mechanisms that affect immune responses and drugmetabolism as well as developed and evaluated block co-polymer microfilm drug delivery systems for enhanced hostimplant tolerance. Prior to joining NUS, Dr. Chow was anAmerican Cancer Society Postdoctoral Fellow under theguidance of Prof. J. Michael Bishop at University of CaliforniaSan Francisco. During this time, he developed a murinesystem for systematically evaluating how specific oncogenesdetermine biological properties of cancer stem cells and wasthe first to demonstrated the potential of nanodiamonds as adrug-delivery and imaging platform for improving cancertherapy and diagnostics in vivo.

cancer therapy, which uses electromagnetic radiations mostoften in infrared wavelength for the treatment of cancer. In thisstudy, we are proposing CD44 targeted IR-780 loaded HA-C18micelles, which can produce ablation temperature upon laserirradiation. Upon irradiation of the tumor site by laser, tumorcells in the area of illumination would be killed by the heatproduced by the NIR dye loaded CD 44 targeted micelles andsubsequently reduced the tumor burden. Furthermore, wedesigned a stimuli responsive, cationic charged micelle as a drugcarrier for treatment of peritoneal metastasis. In vivo studiesshowed enhanced retention efficient inhibition of tumor nodeswith no systemic toxicity. Taken together, design of nanocarriers responding to exogenous or endogenous stimulirepresents an attractive option for triggering the on-demanddrug release and thereby enhancing the therapeutic efficacy.

…….Multi-stimuliregulatednano-micellesfortumor-targetedtherapy

In-Kyu PARKDepartment of Biomedical Sciences

Chonnam National University Medical School, Korea


Abstract

Owing to the outstanding progress in the nanomedicine field, avariety of nanocarriers have been designed to specifically deliverthe cargo to the target site, in response to the specific stimuli.Photo-thermal therapy (PTT) is a light based molecular targeted

Short Bio

In-Kyu Park studied natural fiber science at Seoul NationalUniversity and obtained his Ph.D. in 2002 under thesupervision of Prof. Young Hwan Park and Prof. Chong-SuCho. He pursued his career at the Department ofBiomolecular Engineering, Tokyo Institute of Technology withProf. T. Akaike, and at the Department of Bioengineering,University of Washington with Prof. Suzie H. Pun. He iscurrently a full professor in the Department of BiomedicalSciences, Chonnam National University Medical School. He haspublished over 130 peer-reviewed journal articles, 5 bookchapters and 18 patents to his credit. His research focuses onnanoparticles mediated delivery of therapeutic drug and genes.The fate of those particles in body can be monitored non-invasively by MRI and optical imaging after labelling them withthe appropriate imaging agents. Bio-compatible hydrogels andnanogel can be also utilized for delivering bioactive moleculesincluding proteins and vaccines. His specific interest is on thedevelopment of specific tissue-targeted multi-functionalnanostructures to deliver chemical drugs as well as therapeuticgenetic materials, while tracking them simultaneously. He alsoworks on the development of immunomodulatorynanoparticles for cancer immunotherapy.

…….


can improve contrast agent enhanced magnetic resonance imaging(MRI). Specifically, we will discuss how nanodiamond delivery ofparamagnetic ions can improve MRI imaging sensitivity over clinicalstandards as a method for cancer diagnosis. Finally, we will discusshow nanodiamonds may be useful for delivery of emergingtherapeutics such as biologics. These recent advances in ND drugdelivery of new classes of therapeutics further demonstrate thepotential for a ND-based platform for the development ofpersonalized drug-delivery or imaging complexes.

Bio-sensing/microfluidics/nanofluidics

Session Chair: Gwo-Bin LEENational Tsing Hua Univ., Taiwan

SS1: 10:30 – 12:10Saturday, December 2, 2017Location: Demonstration Hall, 1/F

Description

This session seeks papers that describe studiesinvolving biosensing, microfluidics and nanofluidics.Both theoretical and experimental works arewelcome.

SS1.1 Electrochemical impedance spectroscopy-based affinity biosensing chips integrated with ACelectrokinetic vortexes, Ching-Chou WU, NationalChungHsingUniv., Taiwan (Invited)

SS1.2 Integration of blood filters, vacuummodules, and molecularly-imprinted biosensorson electrical sensing chips for on-site sampleanalysis, Chien-Chong HONG, National Tsing HuaUniv., Taiwan (Invited)

SS1.3 The application of aptamers in moleculardiagnosis, Chih-Hung WANG, National Tsing HuaUniv., Taiwan (Invited)

SS1.4 Machine vision for cell sensing on a chip,Chia-Hung Dylan TSAI, National Chiao Tung Univ.,Taiwan (Invited)

SS1.5 Characteristics and chemosensitivity ofcancer cells cultured in a gel-free papersubstrate, Ghe-Fu LIN; Kin Fong LEI, Chang GungUniv.; Linkou Chang Gung Memorial Hospital,Taiwan (Paper – 8)

SS1.6 Inhibition effect of tumor spheroids underthe electrical stimulation, Chun-Hao HUANG; KinFong LEI, Chang Gung Univ.; Linkou Chang GungMemorial Hospital, Taiwan (Paper – 9)

IEEE-NANOMED TECHNICAL SESSIONS

…….Intelligentdrugdeliverysystemandtherapeuticaltechnology

Session Chair: Ning GUSoutheast Univ., China

SS2: 10:30 – 12:10Saturday, December 2, 2017Location: Lecture Theater, 2/F

Description

Utilization of carriers to deliver drugs intospecific positions in vivo has been a criticalissue in clinic. Nanomaterials here can play animportant role because of the multi-functionand tailorable response to microenvironmentin vivo. In this session, five outstandingscholars will show their fantastic design and

ideas in this area. It will be seen how theorganic as well as inorganic nanostructures areused as a multi-functional platform forsimultaneous detection and therapy such asphotothermia, magnetic force and chemicaltherapy. Furthermore, a magnetic field-directedtargeting technology will be presented for themagnetically-labeled biomaterials.

SS2.1 Tumor-penetrating polymer drug deliverysystem, Xiqun JIANG, Nanjing Univ., China(Invited)

SS2.2 Tungsten oxide asmultifunctional theranosticsystems for multimodal imaging and therapy ofcancer, Shaoqin LIU, Harbin Institute of Technology,China (Invited)

SS2.3 Activatable cancer nanotheranostics, PengHUANG, Shenzhen Univ., China (Invited)

SS2.4 Nanomedicines and stem cells: A potentialmarriage for targeted cancer treatment, YuCHENG, Tongji Univ., China (Invited)

SS2.5 Magnetically controlled specific aggregationof magnetic particles in mouse blood vessel,Jianfei SUN, SoutheastUniv., China (Invited)

…….Micro- andnano-technologiesforengineeringlivingsystems

Session Chair: Jangho KIMChonnam National Univ., Korea

SS3: 10:30 – 12:10Saturday, December 2, 2017Location: B103, 1/F

Description

Micro- and nanoscale environments includingmolecules, biophysical cues, and interactionsbetween cell-cell and cell-substrates playimportant roles to engineer the complex andfunctional living systems. This session willhighlight emerging micro- and nanotechnologiesthat can control functions of living systems. Theseapproaches will provide novel insights intodeveloping new strategies for engineeringfunctions of living systems for variousapplications such as cell therapy, tissueengineering, regenerative medicine, and drugdelivery for improving human life.

SS3.1 Modulating the biomechanical cultureenvironment for improved differentiation ofhuman mesenchymal stem cells, Ki-Taek LIM,Kangwon National Univ., Korea (Invited)

SS3.2 Engineered blood-brain barrier model forrecapitulating brain microvasculature physiology,Hong Nam KIM, Korea Institute of Science &Technology(KIST),Korea(Invited)

SS3.3 Natural resource-derived biomaterials withnanotechnology and 3D printing techniques, HoonSEONWOO,SunchonNationalUniv.,Korea(Invited)

SS3.4 Lipid-based biomimetic assemblies ofnanomaterials, Kyunghoon KIM, SungkyunkwanUniv.,Korea (Invited)SS3.5 Designing multiscale topographical structuresfor controlled morphology and function of cells,JanghoKIM,ChonnamNationalUniv.,Korea (Invited)

…….Newgenerationofmultifunctionalbio-therapeuticnanoparticles

Session Chair: In-Kyu PARKChonnam National Univ. Medical School, Korea


Description

Nanotechnology plays a vital role in biomedicalapplications, especially for the diagnosis andtreatment of various diseases. Particles in the sizerange of 10 to 1000 nanometers are usuallytermed as nanoparticles. They have attractedmuch interest in recent years as ideal candidatesfor various biomedical applications such as drugdelivery systems, biosenors and bio imagingowing to their specific properties of size tunabilityand intrinsic hydrophilic surfaces. This session willinclude a wide-ranging field that encompassesdifferent applications of nanoparticles such asoral delivery of biotherapeutics, cancertheranostics, nanocarrier with bioengineeredstem cell membrane, biodegradable nano-patterned patches and nanoparticle-ladencontact-lens.

SS4.1 Biomacromolecules for ROS-mediated cancertheranostics, Jae Hyung PARK, Sungkyunkwan Univ.,Korea (Invited)

SS4.2 Nanoparticle-laden contact-lens for detectingtear glucose, Dong Yun LEE, Hanyang Univ., Korea(Invited)

SS4.3 Biodegradable nanopatterned patches toregulate cell fate and acceleration of boneregenerations, Hee Seok YANG, Dankook Univ.,Korea (Invited)

SS4.4 Functional nanocarriers with bioengineeredstem cell membrane for therapeutic target inischemia, Soo-HongLEE,CHAUniv.,Korea (Invited)

SS4.5 Taurocholic acid conjugated targetednanocarriers for the oral delivery ofbiomacromolecules, Yong-kyu LEE, KoreaNational Univ. of Transportation, Korea (Invited)

…….


Micro/nano devicesforcancerresearch

Session Chair: Kin Fong LEIChang Gung Univ., Taiwan

SS5: 14:50 – 16:30 Saturday, December 2, 2017Location: Lecture Theater, 2/F

Description

This session seeks papers that describe studiesinvolvingmicro/nano devices for cancer research.Both theoretical and experimental works arewelcome.

SS5.1 Lithographic free cell patterning for tumormetastasis study, Liang ZHAO; Tengfei GUO; LirongWANG; Yang LIU; Ganyu CHEN; Hao ZHOU; MeiqinZHANG,Science&TechnologyUniv.ofBeijing,China.(Invited)

SS5.2 A parallel cell analyzer by using microlensimmersed three-dimensional microfluidic device,Yu-Jui FAN,TaipeiMedicalUniv., Taiwan (Invited)

SS5.3 Optical imaging guided laser therapy foraccurate tumor removal, Meng-Tsan TSAI, ChangGungUniv., Taiwan; ChangGungMemorial Hospital,Taiwan (Invited)

SS5.4 A micromixer for rapid immunoprecipitationof target peptide for oral cancer screening,Wei-TingSU;Ya-YuHSUEH;Heng-YunCHANG;Chia-ChunWU;Yung-ChinHSIAO; Jau-SongYU; Yen-Heng LIN, ChangGungUniv., Taiwan; ChangGungMemorial Hospital,Taiwan (Invited)

SS5.5 Integratingcell cultureand immunoassayonapaper substrate for the study of cellular response,Kin Fong LEI, ChangGungUniv., Taiwan; ChangGungMemorialHospital, Taiwan (Invited)

IEEE-NANOMED TECHNICAL SESSIONS

…….Nano/microsystemsforbiomedicalapplications

Session Chair: Zhan YANGSoochow Univ., China

SS6: 14:50 – 18:10Saturday, December 2, 2017Location: B103, 1/F

Description

This session seeks papers that describe studiesinvolving micro/nano systems for research inbiomedicine or related fields. Both theoreticaland experimental works are welcome.

SS6.1 Smart life and micro nano manufacture,Lining SUN, Soochow Univ., China (Invited)

SS6.2 Biosyncretic sensingandactuationwith livingcells, LianqingLIU, Shenyang InstituteofAutomation,China (Invited)

SS6.3 Bionics acoustical MEMS/NEMS sensingtechnology and application, Xiujian CHOU, NorthUniv.ofChina,China (Invited)

SS6.4 High precision tilt sensor and tiltingmeasurement system, Xueyong WEI, Xian JiaotongUniv.,China (Invited)

SS6.5 Micro-robotic bioassembly of in-vitro liverlobules, Huaping WANG, Beijing Institute ofTechnology,China (Invited)

SS6.6 Self-actuated platinum micro-nano robot,Zhan YANG, SoochowUniv., China (Invited)

SS6.7 A fully automated microflow cytometer forastronauts, Honglong CHANG, Northwestern Poly-technical Univ., China (Invited)

SS6.8 Automated assembly of nanowires patternusing atomic force microscope, Sen WU, TianjinUniv.,China (Invited)

SS6.9 High spatial-temporal resolution bioimagingusing light-sheet fluorescent microscopy system,Peng FEI, Huazhong Univ. of Science & Technology,China (Invited)

SS6.10 Research on the combination of medicineand engineering based on robot technology, JunLUO,ShanghaiUniv.,China (Invited)

SS6.11 Precision assembly technique and equipmentfor miniature devices, Xiaodong WANG, Dalian Univ.ofTechnology,China(Invited)

SS6.12 Micro/nanorobotics for manipulation andmultiparametric characterization, Hui XIE, HarbinInstituteofTechnology,China (Invited)

technic Univ., Hong Kong, China (Invited)

SS7.4 Formation of a neural network on a PEMbasedmicropatterned platform, Yung-Chiang LIU; I-Chi LEE, Chang Gung Univ., Taiwan; Chang GungMemorialHospital, Taiwan (Invited)

SS7.5 Conductive bioimprint for cell culture sensing,Nor Azila A. WAHID; John J. EVANS; Maan M.ALKAISI, Univ. of Canterbury, New Zealand; Univ. ofOtago,NewZealand (Paper–24)

SS7.6Bio-mimicking chemomechanical actuators ascontinuous skinmonitors, Gagan JODHANI;Pelagia I.GOUMA,OhioStateUniv.,USA(Paper–28)

…….Cellmanipulationand3Dbioprinting forcancerdetectionandtissueengineering

Session Chair: Na LIUShanghai Univ., China

SS8: 16:30 – 18:10Saturday, December 2, 2017Location: Lecture Theater, 2/F

Description

Cancer detection and tissue engineering are themost advanced and significant topics in bio fields.Many researchers are contributing to solve thedifficulties related efficiency, accuracy, stability,biocompatibility, etc., in these two topics viadifferent ways. Techniques and systems relatedto manipulation and fabrication in micro/nanoscale could provide favorable solutions for thesedifficulties and have attracted lots of attentions.This session will mainly introduce some recentwork progress on cell manipulation and 3Dbioprinting around the applications of cancerdetection and tissue engineering.

SS8.1 Novel bioactive nanoscale membrane by cellelectrospinning, Yuanyuan LIU, Shanghai Univ.,China (Invited)

SS8.2 Multimodal single-cell death recognitionbased on optically induced electrokinetics cellmanipulation and data mining, Yuliang ZHAO,NortheasternUniv.,China (Invited)

SS8.3 Enzyme analytical biosensor based on self-assembly of lipid bilayer, Juan ZHANG, ShanghaiUniv.,China (Invited)

SS8.4 Development of 3D printing methods forhydrogels, Runhuai YANG, Anhui Medical Univ.,China (Invited)

SS8.5 Detection and regulation of cells’ physicalproperties utilizing micro manipulation andfabricationtechniques,NaLIU,ShanghaiUniv.,China(Invited)

…….Bio-nanomaterials

Session Chair: Kin Fong LEIChang Gung Univ., Taiwan


Description

This session seeks papers that describe studiesinvolving bio/nano materials for biomedicalapplications. Both theoretical and experimentalworks arewelcome.

SS7.1 Magnetic nano-Fe-Rg3 delay hepatocarcino-genesis by remodeling gut microbiota andmetabo-lism, Zhigang REN; Liangjie HONG; Xiaoxiong ZHAO;Xinmei CHEN; Zujiang YU; Yujun SONG; XinhuaCHEN, ZhengzhouUniv., China;ZhejiangUniv., China;Science & Technology Univ. of Beijing, China;Ministryof Public Health, Hangzhou, China;Shandong Univ. ofTraditionalChineseMedicine,China.(Invited)

SS7.2 Two-dimensional materials based nanoprobefor bioimaging and sensing, Mo YANG, Hong KongPolytechnicUniv.,HongKong,China (Invited)

SS7.3 Plasmonic semiconductor nanocrystals:nanotheranostics and toxicity, Wing CheungLAW; Nanxi RAO; Zhourui XU, Hong Kong poly-


…….

Recentplatformtechnolo-gies fornanobiosensor

Session Chair: Hyun Ho LEEMyongji Univ., Korea

SS9: 15:00 – 16:40 Sunday, December 3, 2017Location: Demonstration Hall, 1/F

Description

There has been an expanding burst of novelplatform technologies designed for nanobiosensordevelopment. Recent platforms can include exoticnano-structure, passive microfluidic, cell-culture ororgan system for biomolecule delivery, fibroussystems for sensor, etc. In this session, state-of-artplatform technologies for recent nanobiosensorwill be introduced and discussed toward furtherapplications on the progress of nanomedicine. Inaddition, physical and chemical fundamentalsbehind the novel platform technologies will beelucidated in details and cooperative andintegrative research topics canbe induced.

SS9.1 Biomolecule matrix platforms for bio-electronic sensor, HyunHoLEE,MyongjiUniv., Korea(Invited)

SS9.2 Anti-bacterial and biofilm removal propertiesof metal nanoparticles decorated carbon nano-materials, Jonghoon CHOI, Chung-Ang Univ., Korea(Invited)

SS9.3 Polycation mediated growth factor deliveryfor tissue regeneration, Kyobum KIM, IncheonNationalUniv.,Korea (Invited)

SS9.4 Carbon/agarose gel composite micro-fibers:humidity sensors and super-capacitors, Hyung-JunKOO; Sung-Kon KIM; Ju-Hee SO, Seoul National Univ.of Science & Technology, Korea; Chonbuk NationalUniv., Korea;Korea Instituteof Industrial Technology,Korea (Invited)

SS9.5 Synthesis of optically active chiral nano-structures without lithography, Bongjun YEOM,MyongjiUniv.,Korea (Invited)

IEEE-NANOMED TECHNICAL SESSIONScatenin, and actin. How to modify the surfacepattern would be the key for magnetic type ofdigital microfluidic system. Finally, the design ofmicroreactor array would be performed for high-throughput and low-cost drug screening.

SS10.1 Impedimetric screening of chemosensitivityof cancer cells cultured in a paper-based cell culturemodel, Kin Fong LEI, Chang Gung Univ., Taiwan(Invited)

SS10.2 Microelectrode design for electro-impedancecell counting technologies, Chih-TingLIN,NationalTaiwanUniv., Taiwan (Invited)

SS10.3 Interplay of cadherin and actin filament canregulate hepatocellular carcinoma physiology incirrhotic microenvironment, Chi-Shuo CHEN,NationalTsingHuaUniv., Taiwan (Invited)

SS10.4 Surface patterning for magnetic digitalmicrofluidics-based diagnostic assays, Yi ZHANG,NanyangTechnologicalUniv., Singapore (Invited)

SS10.5 Microreactor array with chemical andoxygen concentration gradient, Szu-I YEH; Jing-TangYANG,NationalChengKungUniv., Taiwan (Invited)

…….Microfluidicsystemforbiomedicalapplications

Session Chair: Da-Jeng YAONational Tsing Hua Univ., Taiwan

SS10: 15:00 – 16:40Sunday, December 3, 2017Location: Lecture Theater, 2/F

Description

This session would introduce several bio-medicalapplications by using microfluidic system. Impe-dance based technique will be applied for cellcounting and cancer cell screening. Cell based imagesystemwill beused for Interaction among cadherin,

…….Micro/nano roboticsforbiomedicalapplications

Session Chair: Yajing SHENCity Univ. of Hong Kong, China

SS11: 15:00 – 16:40Sunday, December 3, 2017Location: B103, 1/F

Description

This session seeks papers that describe studiesinvolving nano/micro robotic systems for bio-medical applications or related research areas.Both theoretical and experimental works arewelcome.

SS11.1 Micro-nano robot for scanning electronmicroscopy, Yajing SHEN, City Univ. of Hong Kong,China (Invited)

SS11.2 MHz functional photoacoustic microscopy,LidaiWANG,CityUniv.ofHongKong,China (Invited)

SS11.3 Cytokine profiling of immune cells usingfluorescence microbeads in microfluidics, RaymondH.W.LAM,CityUniv.ofHongKong,China (Invited)

SS11.4 Microrobotic swarms of magnetic colloidsforenhanced local hyperthermia, Li ZHANG,ChineseUniv.ofHongKong,China (Invited)

SS11.5 Construction of protein-based CuS nano-platform for biomedical applications, Duyang GAO;ZhenYUAN,Univ.ofMacau,China (Invited)

…….

Magneticnanomaterialsandtissueengineering

Session Chair: Ning GUSoutheast Univ., China

SS12: 11:30 – 13:10 Monday, December 4, 2017Location: Demonstration Hall, 1/F

Description

Magnetic iron oxide nanoparticles owned aspecial role in biomedical nanotechnologybecause it is the only one inorganic nanomaterialapproved by FDA for clinical application.Currently, there is increasing interests inmagnetic nanomaterials. This session will inviteseveral outstanding scholars in this area to showtheir works on magnetic nanomaterials andapplication in tissue engineering which is thebasis of regenerative medicine. It will be seen themagnetic nanomaterials have a wide biomedicalapplication ranging from imaging to therapy.Especially, the magnetism has been found tohave promising influence upon the tissue repair.

SS12.1 Construction and application prospect ofmagneto-bubbles, Fang YANG, Southeast Univ.,China (Invited)

SS12.2 Advanced biomedical magnetic nano-platforms, Haiming FAN, Northwest Univ., China(Invited)

SS12.3 A potential nano-material substituted togadolinium-based chelates for contrast enhance-ment of magnetic resonance imaging, HaitaoHUANG,Univ.ofMinnesota,USA(Invited)

SS12.4 Modulation of cells function to promotebone tissue regeneration using super-paramagneticscaffolds, Haiyan XU, Chinese Academy of MedicalSciences,China (Invited)

SS12.5Theapplicationof ironoxidenanoparticles inoral bone tissue engineering, Yang XIA, NanjingMedicalUniv.,China (Invited)

…….Micro-engineeredplatformforsoftmattersandcellresearch

Session Chair: Ting-Hsuan CHENCity Univ. of Hong Kong, China

SS13: 11:30 – 13:10Monday, December 4, 2017Location: Lecture Theater, 2/F

Description

Leveraging the micro/nanotechnology enablesunprecedented accessibility for research in thesmall scale. In this invited session, we provide avenue for discussing an array of micro-engineeredplatforms with factors ranging from fluidic, optic,


IEEE-NANOMED TECHNICAL & POSTER SESSIONSand nanomaterials for investigation of soft matter and cellresearch, such as emulsion, mechanobiology, cell-nicheinteraction, and biosensors. It is anticipated to bringinspiration propelling researches with new possibilities.

SS13.1Droplet-basedelectro-coalescence for rapidcharacterizationofemulsionstability, LiuZHOU,ShenzhenUniv.,China (Invited)

SS13.2 Multiphoton fabrication technology: A feasible platform forcell nichestudy, XinnaWANG;BarbaraCHAN,UniversityofHongKong,China (Invited)

SS13.3 Personalized microfluidic elastofiltration (pMEF) system forcancer diagnosis: from basic research to clinical study, Yi-Kuen LEE,HongKongUniv.of ScienceandTechnology,China (Invited)

SS13.4 Nanowire magnetoscope reveals a rota-tional bias in cellmechanics, Ting-HsuanCHEN,CityUniv.ofHongKong,China (Invited)

…….Nano/biosensing

Session Chair: Vellaisamy A.L. ROYCity Univ. of Hong Kong, China

SS14: 11:30 – 13:10Monday, December 4, 2017Location: B103, 1/F

Description

This session seeks papers that describe studies involving bio/nanosensing. Both theoretical and experimental works arewelcome.

SS14.1 Surface enhancement raman scattering substrate based onpolymermaterials, Long-BiaoHUANG,ShenzhenUniv.,China (Invited)

SS14.2 Nanosensors for imaging biomolecules in vivo, Kannie W.Y.CHAN, CityUniv. of HongKong, China; JohnsHopkinsUniversity SchoolofMedicine,USA(Invited)

SS14.3Largeareaorganic temperaturesensorarray, PaddyK.L. CHAN,Univ.ofHongKong,China (Invited)

SS14.4 Sensors for food safety and water quality monitoring,VellaisamyA.L.ROY,CityUniv.ofHongKong,China (Invited)

…….

POSTERSESSIONSunday, December 3, 2017Location: Foyer, 1/F

PS1 Tip-assisted electrohydrodynamic printing for fabrication ofmicro-nano structures, Wuhao ZOU; Haibo YU; Peilin ZHOU; ZhiwenYANG; Lianqing LIU, Shenyang Institute of Automation, ChineseAcademy of Sciences, China (Paper – 13)

PS2 Fabrication of flexible microlens arrays for parallel super-resolution imaging, Tianyao ZHANG; Haibo YU; Feifei WANG; Pan LI;Tie YANG; Yuechao WANG; Lianqing LIU, Shenyang Institute ofAutomation, Chinese Academy of Sciences, China (Paper – 14)

PS3 Electroconductive graphene oxide-nanosheets: potential andnew horizons of nanocomposites on stem cells, Yu-Ri SEO; Hye-Been KIM; Ki-Taek LIM, KangwonNational Univ., Korea (Paper – 15)

PS4 A convenient and common method to measure the collectivemagnetic moments of magnetic materials in fluid by analysis ofmoving video, Haoyao WANG; Jianfei SUN; Lina SONG; QingdongCAI; Ke HU; Peng WANG; Yijun LIANG; Ning GU, Southeast Univ.,China; NanjingMedical Univ., China (Paper – 18)

PS5 Temperature detection of vascular endothelial cells stimulatedby norepinephrine with high precision thermal resistancethermometry, Can LI; Weiguo ZHANG; Sheng YANG; Weinan HE;Ning GU, Southeast Univ., China (Paper – 19)

PS6 Extracellular topographical and chemical cues for accelerationof neuronal development, Sunho PARK; Daun KIM; Dohyeon LEE;Woochan KIM; Jangho KIM, Chonnam National Univ., Korea (Paper– 21)

PS7 Engineering wound healing using directional matrix nano-topography with varied sizes, Daun KIM; Sunho PARK; DohyeonLEE; Woochan KIM; Jangho KIM, Chonnam National Univ., Korea(Paper – 22)

PS8 Process automation and batch for W-Pt micro-nanothermocouple preparation, Sheng YANG; ChanglingWANG; JianqingWANG; Wenjuan TIAN; Weinan HE; Ning GU, Southeast Univ.,China; NanjingMedical Univ., China (Paper – 23)

PS9 Carbon nanotubes influence dendritic cells maturation and Tcell polarization, Jie MENG; Xin NIE; Jian LIU; Haiyan XU, PekingUnionMedical College, China (Paper – 25)

PS10 Carbon nanotube-coated cotton yarn for weak bioelectricsignal measurement, Yuliang ZHAO; Qingyun HUANG; Wen Jung LI,City Univ. of Hong Kong, China (Paper – 27)

PS11 Engineering liquid-phase stability of cellulose nanocrystalfilms for biological applications, Joseph BATTA-MPOUMA; ArvindSINHA; Angele DJIOLEU; Jeong-Min LIM; Joshua SAKON; HaewookHAN; Jin-Woo KIM, University of Arkansas, USA; Pohang Univ. ofScience and Technology, Korea (Paper – 29)

…….


Documents

NANOMED 2017-Tech Digest-Final-R2 · Gwo-Bin Lee received his B.S. and M.S. degrees in Department of Mechanical Engineering from National Taiwan University in 1989 and 1991, respectively