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7/22/2019 MYCOTOXINS IN ANIMAL HEALTH
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ARFIJM ^C_GFP (EW@C^C_GFP)JFN
HJ@^BXGJM ^C_GFP
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EW@C^C_GFP
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EW@C^C_GFP
Pb`cfnjry ebtjhcmgtbs ca tcxgibfg` aufig cf jfgejm
abbn jfn accn gfirbngbfts wog`o `jusb jnvbrsb
hgcmcig`jm baab`ts wobf `cfsuebn gf suaag`gbft
qujftgtgbs. ^cxgibfg` aufig prcnu`b tobgr tcxgfs wobf
tbepbrjturb, ecgsturb jfn jbrjtgcf jrb ajvcurjhmb.
Egfgeue :2% ecgsturb (:
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@ojrj`tbrgstg`s ca Ey`ctcxgfs
Fct trjfsegssghmb arce cfb jfgejm tc ctobr, sc jrbfct gfab`tgcus.
Cuthrbjds jrb usujmmy sbjscfjm.
Jnvbrsb baab`ts cf objmto & prcnu`tgcf gf jmm spb`gbs ca
jfgejms jfn hgrns.
Ircwgfi, prbifjft jfn mj`tjtgfi cfbs jrb wcrst jaab`tbn
Ojvb spb`gag` jssc`gjtgcf wgto j pjrtg`umjr abbn.
^rbjtebft wgto jftghgctg`s ojs mgttmb baab`t cf tob
ey`ctcxgfs jfn tob `cursb ca ngsbjsb.
Geeufcsuprbssgvb.
Ecumn gfabstbn abbn, pccr futrgtgcf, gfjnbqujtb ngbt jrb
prbngspcsgfi aj`tcrs.
Ptrbss, gfsb`t njejib jfn pmjft ngsbjsb bfojf`b tcxgf
prcnu`tgcf.
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EW@C^C_GF ^W\BP/ @MJPPGAG@J^GCF
OB\J^C^C_GFP
Jamjtcxgfs -Jspbrigmmus amjvus, J. pjrjsgtg`us.
Ppcrgnbsegf- \gtocey`bs ojrtjfue
Xuhrjtcxgfs - \bfg`gmmgue ruhrue, \.purpurcibfue.
Ctobr- stbrgiejtc`ystgf, mutbcsdyrgf, y`mc`omcrctgfbFB\OXC^C_GFP
C`orjtcxgfs- Jspbrigmmus c`orj`bus,
\bf`gmmgue vgrgng`jtue
@gtrgfgf- \bf`gmmgue `gtrgfue, J.c`orj`bus
CBP^XCIBFG@ EW@C^C_GFP
[brjmbfcfb(A8 tcxgf) Ausjrgue rcsbue
@W^C^C_G@ EW@C^C_GFP
^rg`octob`bfbs(^-8 tcxgfs)- Ausjrgue sp. A.irjejbfjrbue jfn
A. rcsbue.FBRXC^C_G@ EW@C^C_GFP
^rbecribfs- \jtumgf jfn \bfgtrbe J- \bfg`gmmgue Jspbrigmmus jfn @mjvg`bps
EGP@BMMJFBCRP
Brictcxgfs@mjvg`bps purpurbj jfn @. pjspjmg.
Abs`ub tcxgf- Fbctypocgngue cbfcpogjmue
Pmjarjegfb- Xogzc`tcfgj mbiuegfg`cmj
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@ceecfmy bf`cuftbrbn ey`ctcxgfs gf vjrgcus
`cftjegfjtbn accn jfn abbns jrb
Jamjtcxgfs- gf wjre, ouegn rbigcfs
C`ojrctcxgf-J
[bjrjmbfcfb gf `cmn, tbepbrjtb rbigcfs
^rg`octob`bfbs
@gtrgfgf
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@OJXJ@^BXBP^G@P CA EW@C^C_GFP
.
Jamjtcxgfs jaab`t jmm ncebstg` jfgejms.
[bjrjmbfcfb jfn vcegtcxgf ejgfmy jaab`t swgfbjfn njgry
jfgejms.
Auecsgfs ejgfmy jaab`t swgfbs jfn bqugfbs.
-8 tcxgf, c`ojrctcxgf, ngj`btcxys`grpbfcm (NJP) jaab`tejgfmy swgfbjfnpcumtry.
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AM ^C_G@CPGP
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JAMJ^C_GFP Jamjtcxgfs jrb tob tcxg` ebtjhcmgtbs ca tcxgibfg` aufigJspbrigmmus amjvus
jfnJ. pjrjsgtg`us.
Agrst ngs`cvbrbn gf Bfimjfn gf:71 -82`)
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@OBEGP^XW
Pbvbrjm jamjtcxgf arj`tgcfs ojvb hbbf gscmjtbn jfn ngaabrbftgjtbnarce cfb jfctobr hy
^obgr amucrbs`bf`b ufnbr umtrjvgcmbt 4 XA vjmubs cf togf mjybr`orcejtcirjpoy jfn Ptru`turjm gnbftgag`jtgcf jfn syftobsgs
^ctjm :? `cepcufns gf tob jamjtcxgf ajegmy
Acur gepcrtjft cfbs
H: & H8 (amucrbs`b hmub ufnbr mcfi wjvb RQ mgiot)
I: & I8 (amucrbs`b irbbf ufnbr mcfi wjvb RQ mgiot)
Jamjtcxgfs wgto hmub amucrbs`bf`b ufnbr umtrjvgcmbt mgiot jrb H:(ecst tcxg`) jfn H8.
Ngoynrcnbrgvjtgvbs ca H: jfn H8jfn amucrbs`b irbbf jrb nbsgifjtbnjs I:jfn I8.
Oynrcxymjtbn ebtjhcmgtbs ca H:jfn H
8jamjtcxgfs jrb bx`rbtbn gf egmd
jfn jrb tbrebn js E:jfn E8.
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MB^OJM NCPB 2-2 tgebs ecrb pctbft
`cepjrbn tc ngoynrc nbrgvjtgvbs.
^ob stru`turb ca H tcxgf rbsbehmbs `mcsbmy wgto tob
stru`turb ca pyrrczcmgncfb wog`o ojs ict hjsg`
`jr`gfcibfg` j`tgvgty.
Jamjtcxgfs jrb pctbft eutjibfs, `jr`gfcibfs, tbrjtcibfs
jfn mgvbr njejigfi jibfts.
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Aj`tcrs jaab`tgfi tcxg`gty ca jamjtcxgfs; Ppb`gbs vjrgjtgcfs-Nu`ds, rjhhgts, ncis, pgis, `jmvbs, `og`dbf,
`cws, qujgm jfn sobbp jrb sus`bptghmb gf tob crnbr ca prbabrbf`b.
Hrcgmbrs jrb ecrb sus`bptghmb tojf mjybrs.
@jmvbs jrb ecrb sus`bptghmb tojf jnumt njgry `jttmb.
Ejxgeue jmmcwjhmb `cf`. gf njgry `jttmb gs 8< pph (
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^C_G@CNWFJEG@P
Ejkcrgty ca tob jamjtcxgfs gfibstbn gf abbn jrb poysg`jmmy
hcufn tc ruegfjm `cftbfts jfn js mgttmb js 8-2% rbj`o tob
gftbstgfbs.
Jamjtcxgf H: gf bx`bss ca :
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JAH: gs prgejrgmy ebtjhcmgzbn hy j eg`rcscejm `ytc`orceb \->2 ei/di ca jamjtcxgf `jusbs nbjto ca sobbp,
`jmvbs jfn pgis wgto gf :2 -:? ocurs nub tc j`utb obpjtg`
gfsuaag`gbf`y
Ygto 8 ei/di, tobrb gs jfcrbxgj, gf`rbjsbn rbspgrjtgcf rjtb,
gf`rbjsb gf hcny tbepbrjturb jfn ngjrrocbj wgto hmccn jfn
eu`us.
^ob `mgfg`jm sgifs gf ncis jppbjr gf 8-:> njys (jvbrjib 2 njys)
jfn jrb `ojrj`tbrgzbn hy jfcrbxgj, g`tbrus, hgmb stjgfbn urgfb,
prcstrjtgcf, c``jsgcfjmmy hmccn gf ajb`bs, vcegtgcf
(scebtgebs hmccny), bpgstjxgs jfn rjrbmy `cfvumsgcfs.
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MN2
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@orcfg` tcxg`gty `cftn
\gis jmsc bxoghgt sgegmjr sgifs4 tobrb jrb gftbregttbft ojbecrrojibs
jfn ngjrrocbj. bxoghgt sbgzurbs hbacrb nbjto.
Ocrsbs -typg`jm sgifs ca obpjtg` tcxg`gty jfn ijstrcgftbstgfjm upsbt
Pobbp, ocwbvbr, jrb rbarj`tcry tc tobsb baab`ts js tob bwbs abn cf
ogiomy tcxg` ircufnfut ebjm acr 2 ybjrs ajgmbn tc bxoghgt jfy `mgfg`jm
sgifs ca jamjtcxg`csgs bx`bpt acr rbnu`bn abrtgmgty.
Gf pcumtry, jamjtcxgfs gftbrabrb wgto jhscrptgcf ca mgpgns jfn
trjfspcrtjtgcf ca ycmd. Bii prcnu`tgcf jfn bii sgzb jrb rbnu`bn.
Gf`rbjsbs sus`bptghgmgty ca turdbys tc `c``gngcsgs, pjstburbmmcsgs
jfn sjmecfbmmcsgs jfn ca `og`dbf tc `c``gngcsgs jfn Ejrbd's
ngsbjsb.
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\cst ecrtbe mbsgcfs;
(g) Mgvbr gs pjmb, agre jfn aghrcsbn.
(gg) Eg`rcs`cpg`jmmy, `bftrgmchumjr fb`rcsgs, hgmb nu`t prcmgabrjtgcf jfn vbfc c``musgcf
jrb tob ejgf `ojfibs. Obpjtc`ytbs jrb swcmmbf, tobrb jrb eumtgpmb ac`g ca
fb`rcsgs jfn aghrcsgs jfn obpjtg` `jr`gfcej.
(ggg) Dgnfbys jrb ybmmcw jfn surrcufnbn hy wbt ajt gf ycufi `jmvbs.
(gv) Pbrcus bxunjtb gf tob hcny `jvgtgbs.
(v) Cbnbej jfn js`gtbs ca ebsbftbry.
vg) @jtjrrojm bftbrgtgs.
(vgg) Bvbrsgcf ca rb`tue.
(vggg) Ojbecrrojibs gf tocrj`g` jfn pbrgtcfbjm `jvgtgbs. Mgvbr gs ybmmcw jfn ecttmbn gf
ncis, ocwbvbr, gt gs caa wogtb tc hrgiot crjfib jmcfiwgto prcmgabrjtgcf ca hgmb nu`t,
suh`utjfbcus ojbecrrojibs, js`gtbs jfn cbnbej ca ebsbftbry gf pgis.
(gx) Ngjrrocbj jfn nysbftbry.
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NGJIFCPGP
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NGJIFCPGP
Ogstcry jfn `mgfg`jm sgifs
Fb`rcpsy agfngfis
Mjhcrjtcry gfvbstgijtgcf ca abbn jfn ctobr
sjepmbs- hmccn, egmd, urgfb bt`-^M@,O\M@,XGJ,BMGPJ
NGAABXBF^GJM NGJIFCPGP wjrajrgf pcgscfgfi (`cjiumjtgcf nbab`ts)
@cjm tjr pcgscfgfi (ecttmgfi ca mgvbr)
`cppbr pcgscfgfi (obecmysgs)
gfab`tgcus obpjtgtgs , ctobr obpjtctcxg`gty nub tc
@@g>, pyrrcmgzgncfb jmdjmcgns
Ctobr ecumns tcxgfs
M h g g g
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Mjhcrjtcry gfvbstgijtgcfs
Hmccn bxjegfjtgcf ca jamjtcxg`csgs jaab`tbn jfgejms
wcumn rbvbjm bmbvjtgcfgf hmccn sbrue mbvbms ca JP^, Jmdjmgfb pocspojtjsb
Gsc`gtrjtb nboynrcibfjsb, Mj`tjtb nboynrcibfjsb
Ijeej-imutjeym trjfspbptgnjsb , Imutjejtb nboynrcibfjsb
Hgmgruhgf. Hmccn `mcttgfi nbab`ts jfn bxtbfsgvb ojbecrrojibs jrb
chsbrvbn gf jmecst jmm spb`gbs ca jfgejms nub tc gepjgrebft cahmccn `mcttgfi aj`tcrs - GG, QGG, G_ jfn _.
Ojbecmytg` syfnrceb gs vbry `ceecf gf pcumtry.
Nb`rbjsb gf sbrue tctjm prctbgfs jfn bmbvjtgcf gf hmccn urbjfgtrcibf jrb jmsc chsbrvbn.
Hcto tob `bmm ebngjtbn jfn ouecrjm geeufb rbspcfsb jrbsupprbssbn.
\rbvbftgcf jfn trbjtebft;
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\rbvbftgcf jfn trbjtebft;
@cftjegfjtbn abbn eust hb wgtonrjwf geebngjtbmy.
\rcvgnb bjsgmy ngibstghmb mcw ajt jfn ogio prctbgf ngbt/abbn.
Puppcrtgvb tobrjpy wgto eumtgvgtjegfs.
-2 njys
gftbrvjm tc nb`rbjsb obpjtg` njejib.
J`tgvjtbn `ojr`cjm L 1.9 ei/di gftrjruegfjmmy js 0
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\rbvbftgcf jfn trbjtebft`cftn
Puppmbebft tob ngbt wgto vgtjegf B jfn sbmbfgue tc
jebmgcrjtb tob baab`ts ca jamjtcxgfs.
Puppmbebft tob ngbt ca jaab`tbn jfgejms wgto obpjtctcfg`s. \rbvbft ufnub strbss tc tob jaab`tbn jfgejms.
(ANJ `cfsgnbrs jamjtcxgfs gf egmd jfn ebjt js j sbrgcus torbjt
tc ouejf objmto jfn j sbrgcus rbiumjtcry vgcmjtgcf)
^rbjtebft ca irjgfs wgto jfoynrcus FO0,O8c8,@omcrgfb,C0hut baag`j`y fct hbbf bstjhmgsobn
J`tgvjtbn `ojr`cjm 1.9 ei / Di G/X js 0
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EW@C^C_GF HGFNBXP Ey`ctcxgf jnscrhbfts caabr jf jttrj`tgvb socrt-tbre scmutgcf tc tob
`ojmmbfib ca ey`ctcxgf-`cftjegfjtbn jfgejm abbns.
^ob cfmy `cepmbtb scmutgcf tc tob ey`ctcxgf `ojmmbfib wgmm hb tob mcfi-tbre
icjm ca bmgegfjtgfi ey`ctcxgfs arce tob accn jfn abbn `ojgfs torcuio
geprcvbn qujmgty `cftrcm hjsbn cf hbttbr jfjmytg`jm tb`ofgqubs `cupmbn
wgto ibfbtg` jnvjf`bs gf pmjft rbsgstjf`b tc aufijm gfabstjtgcf.
Ey`ctcxgf hgfngfi gs j`ogbvbn torcuio hcto;
\oysg`jm jnscrptgcf
Xbmjtgvbmy wbjd hcfngfi gfvcmvgfi vjf nbr Yjjms gftbrj`tgcfs jfn
oynrcibf hcfngfi
@obeg`jm Jnscrptgcf;
(@obegscrptgcf) gs j strcfibr gftbrj`tgcf wog`o gfvcmvbs gcfg` cr
`cvjmbft hcfngfi. Jf baab`tgvb hgfnbr cr sbqubstbrgfi jibft gs cfb tojt prbvbfts cr mgegts
ey`ctcxgf jhscrptgcf arce tob ijstrc-gftbstgfjm trj`t ca tob jfgejm. Gf
jnngtgcf, toby socumn hb arbb arce gepurgtgbs jfn cncurs. Hb jwjrb tojt
fct jmm jrb bqujmmy baab`tgvb. Ejfy `jf gepjgr futrgbft utgmgsjtgcf jfn jrb
ejgfmy ejrdbtbn, hjsbn cf gf-vgtrc njtj cfmy.
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Crijfg` JnscrhbftsCrijfg` ey`ctcxgf jnscrhbfts jrb `jrhcf hjsbnpcmyebrs. Bxjepmbs `cumn gf`munb;
aghrcus pmjft scur`bs su`o js; cjt oumms
wobjt hrjf
jmajmaj aghrb
bxtrj`ts ca ybjst `bmm wjmm `bmmumcsb
obeg-`bmmumcsb
pb`tgf
Pu`o ejtbrgjms jrb hgcnbirjnjhmb hut `jf, gf sceb`jsbs, jmsc hb vb`tcrs ca ey`ctcxgf `cftjegfjtgcf.Hbfbagts ca ybjst `bmm wjmm jrb mcw gf`musgcf, ogiosuraj`b jrbj jfn `brtjgfmy fc tcxg` `cftjegfjfts.
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XRHXJ^C_GF
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PCRX@B`cftjegfjtbn abbn
`c-bxgst wgto jamjtcxgfs
\rcnu`bn hy aufius - \bfg`gmmgue ruhrue,
\.purpurcibfue
@OBEGP^XW
C``urs gf ^wc acres- Xuhrctcxgf J & H
XH^J ; \bf`gmmgue ruhrue
XH^H ; pbf`gmmgue purpurcibfue
^cxg`gty gs nub tc prbsbf`b ca ufsjturjtbnmj`tcfb rgfi
Ojbecrrjiog` syfnrceb gf pcumtry- agrstrb`cifgsbn
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\XC\BX^GBP
Gfscmuhmb gf cgm & wjtbr
Pcmuhmb gf jm`ococm jfn bstbrs
Ptjhmb jt rcce tbepbrjturb(Objtgfi jt ?2-:
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^C_G@CNWFJEG@P
J`tgcf sgegmjr tc jamjtcxgfs
hgfn tc `bmm ej`rcecmb`umbs- NFJ,XFJ jmtbr
tob auf`tgcf
Mbtojm baab`ts cf J^\ jsbs jfn bmb`trcf
trjfspscrt systbe
Pbvbrb mgvbr njejib jfn Objecrrojig`
pfubecfgj
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Eb`ojfgse ca j`tgcf
XHt-H
Xhth: bpcxgnb
Gftbrj`ts wgto Ej`rcecmb`umbs ca Obpjtc`ytbs
NFJ & XFJ pcmyebrjsb
\rctbgf syftobsgs
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Eb`ojfgse ca j`tgcf
XH^- H
J^\ jsbs(egtc`ocfnrgjm) Ngstgftbirjtgcf
ca
Gcfg` ecvbebft J`rcss Egtc`ocfnrgjm ebehrjfb Xghcscebs
Mcss ca stru`turjm & Auf`tgcfjm Gftbirgty ca Egtc`ocfnrgj \rctbgf
syftobsgs
Obpjtctcxg`gty
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^C_G@CDGFB^G@P
Mgvbr ebtjhcmgse
Imu`crjfgnb & sumpojtb `cfkuijtbs
Bx`rbtbn gf hgmb,urgfb ,abj`bs
Bftbrcobpjtg` `y`mb
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syeptces
Pgifs rbmjtbn tc obpjtctcxg`gty
Jfcrbxgj
Nboynrjtgcf
Nbprbssgcf Kjufng`b
Ngjrrocbj
Ybgiot mcss
Pwgfb ; objn prbssgfi& `cmg`
Ocrsb ; Gf`crngfjtgcf
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\E MBPGCFP
Obecrrojibs gf vjrgcus crijfs
Xbfjm njejib
Ocrsb ; hrjgf obecrrojib
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NGJIFCPGP
Ogstcry
Pyeptces
Mbsgcfs
Mjh tbstsnbtb`tgcf ca ruhrctcxgf gf urgfb jfnabbn hy `orcectcirjpoy
NN;- Jamjtcxg`csgs
Fc spb`gag` trbjtefbt
Ygtonrjwm ca `cftjegfjtb nabbn, suppcrtgvbtrbjtebft
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^XBJ^EBF^
Pyeptcejtg`
Ygtonrjwm ca suspb`tbn abbn
Jfjhcmg` Ptbrcgns
J`tgvjtbn `ojr`cjm
Amugn tobrjpy
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P\CXGNBPEGFP
P\CXGNBPEGFP
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P\CXGNBPEGFP jrb sb`cfnjry ebtjhcmgtbs ca tob sjprcpoytg` aufius \gtocey`bs `ojrtjrue,
(Ppcrgnbsegue hjdbrg)wog`o ircws cf nbjn pjsturb mgttbr.
^ob wjre ircufn tbepbrjturbs jfn ogio ouegngty rbqugrbn acr rjpgn ircwto
ca togs aufius rbstrg`t ngsbjsb c``urrbf`b tc oct sueebr jfn jutuef pbrgcns
socrtmy jatbr wjre rjgfs.
^ob spcrgnbsegfs jrb bx`rbtbn vgj tob hgmgjry systbe, gf wog`o toby prcnu`b
sbvbrb `ocmjfigtgs jfn pbrg`ocmjfigtgs js j rbsumt ca tgssub fb`rcsgs.
Hgmgjry chstru`tgcf ejy hb sbbf, wog`o rbstrg`ts bx`rbtgcf ca hgmb pgiebfts jfn
rbsumts gf kjufng`b.
Pgegmjrmy, ajgmurb tc bx`rbtb poymmcbrytorgf gf hgmb mbjns tc poctcsbfsgtgsjtgcf.
\rbvgcus gfibstgcf ca tcxg` spcrbs `jusbs pctbftgjtgcf, tous j su``bssgcf ca
sejmm gftjdbs ca tob spcrbs `jf mbjn tc suhsbqubft sbvbrb cuthrbjds
@mgfg`jm Agfngfis Mbsgcfs
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@mgfg`jm Agfngfis, Mbsgcfs
poctcsbfsgtgsjtgcf jfn kjufng`b jppbjr -: njys jatbrgftjdb ca tob tcxgfs.
Jfgejms arjftg`jmmy sbbd sojnb.
Bvbf socrt bxpcsurb tc tob suf rjpgnmy prcnu`bs tob typg`jmbrytobej jfn bnbej ca poctcnbrejtgtgs gf ufpgiebftbn sdgf.^ob jfgejms suaabr `cfsgnbrjhmy, jfn nbjtos c``ur arce cfb tcsbvbrjm wbbds jatbr poctcnbrejtgtgs jppbjrs.
\E Mbsgcfs;
@ojrj`tbrgstg` mgvbr jfn hgmb nu`t mbsgcfs jrb sbbf gf jmm jaab`tbnjfgejms
mgvbrs jrb gfgtgjmmy bfmjribn, g`tbrg`, jfn ojvb j ejrdbn mchumjrpjttbrf. Mjtbr, tobrb gs jtrcpoy jfn ejrdbn aghrcsgs.
Ibfbrjmmy, tobsb jrbjs jrb jssc`gjtbn wgto aghrcsgs jfntog`dbfgfi ca `crrbspcfngfi hgmb nu`ts.
^ob hmjnnbr eu`csj `ceecfmy socws obecrrojig` crhgmbpgiebft- stjgfbn um`brjtgvb brcsgcfs wgto `gr`ues`rghbnbnbej.
^rbjtebft jfn @cftrcm
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^rbjtebft jfn @cftrcm
^c egfgegsb gftjdb ca pjsturb mgttbr jfn tcxg` spcrbs,socrt irjzgfi socumn hb jvcgnbn.
Ctobr abbnstuaas socumn hb abn nurgfi njfibr pbrgcns ^rbjtgfi acr obpjtgtgs jfn poctcsbfstgzjtgcf
Jftghj`tbrjgms, jftgogstjegfg`s
zgf` sumpotb gf wjtbr(1i/:
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C@OXJ^C_GF
Abbns jaab`tbn- Yobjt ryb, @crf , Hjrmby , @brbjm irjgfs
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Abbns jaab`tbn Yobjt ryb, @crf , Hjrmby , @brbjm irjgfs
C`orjtcxgfs jfn `gtrgfgf jrb prcnu`bn hy sbvbrjm spb`gbs ca ibfbrj
Jspbrigmmus jfn \bfg`gmmgue.
^ob twc ecst `ceecf spb`gbs tojt prcnu`b c`orjtcxgf J (C^J)
jrbJspbrigmmus c`orj`bus jfn \bfg`gmmgue vbrru`csue.
^obsb aufig jrb uhgqugtcus jfn tob pctbftgjm acr `cftjegfjtgcf cajfgejm abbn jfn ouejf accn gs wgnbsprbjn.
Jspbrigmmus spp. jppbjrs tc prcnu`b c`orjtcxgfs jt `cfngtgcfs ca
ogio ouegngty jfn tbepbrjturb
@gtrgfgf wjs agrst gscmjtbn js j purb `cepcufn arce j `umturb ca \.
`gtrgfue gf :70:. Mjtbr, gt wjs jmsc gscmjtbn arce J. c`orj`bus, \.
vbrru`csue, jfn rbmjtbn spb`gbs tojt `cftjegfjtb irjgf.
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AJ@^CXP JAAB@^GFI ^C_G@G^W
Ecsgturb `cftbft 6:1%
XO 6 ?2%
^bepjrjturb :8-82
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@OBEGP^XW
Gsc`cuejrgf `cepcufnsPyftobsgzbn arce pobfym jmjfgfb
Fgfb c`orjtcxgfs prbsbft4 J gs ecrb tcxg`
Crjm tcxg` ncsb acr swgfb & pcumtry :-2p
^C_G@CDGFB^G@P
J`gtvb ebtjhcmgtbs c`orjtcxgf q & pobfym
jmjfgfbhy eg`rcscejm EAC
Xbsgnub gf dgnfby ,Acbtjm mjeh hmccn
@rcssbs pmj`bftjm hjrrgbr
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^C_G@CNWFJEG@P
J`tgcf cf rbfjm \@^
Nb`rbjsb ebtjhcmgtb `mbjrjf`b jfn urgfb`cf`bftrjtgcf jhgmgty
Gfoghgt jfgcf trjfspcrt & rbmbjsb ca rbfjm hrusohcrnbr bfzyebs
Gftbrabrb wgto prctbgf syftobsgs prctbgf,XFJsyftobsgs
Ngsruptgcf ca `jrhcoynrjtb ebtjhcmsgeGf`rbjsbn arbb rjng`jm ibfbrjtgcf vgj @yt p>2 tgebs mbss
tojf bstrjngcm.
Bstrcibfgse nub tc zbjrjmbfcfb wjs agrst `mgfg`jmmyrb`cifgsbn js vumvcvjigfgtgs gf prbpuhbrtjm igmts abn ecmny
`crf (ejgzb)
Ogio ngbtjry `cf`bftrjtgcfs jrb rbqugrbn tc prcnu`b
ngsbjsb gf `jttmb jfn sobbp, jfn bxtrbebmy ogio ncsjibs jrbrbqugrbn tc jaab`t pcumtry.
@mgfg`jm Agfngfis
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@mgfg`jm Agfngfis
\oysg`jm jfn hbojvgcrjm sgifs ca bstrus jrb gfnu`bn gf ycufiigmts hy js mgttmb js : ppe ngbtjry zbjrjmbfcfb.
Gf pgis, zbjrjmbfcfb prgejrgmy jaab`ts wbjfbn jfnprbpuhbrtjm igmts, `jusgfi oypbrbegj jfn bfmjribebft ca tobvumvj.
^obrb gs oypbrtrcpoy ca tob ejeejry imjfns jfn utbrus, wgto
c``jsgcfjm prcmjpsb ca tob utbrus gf sbvbrb `jsbs. Gfeumtgpjrcus scws, sgifs gf`munb ngegfgsobn abrtgmgty, jfbstrus,rbnu`bn mgttbr sgzb, sejmmbr caasprgfi, jfn prchjhmy abtjmrbscrptgcf.
@cfstjft bstrus cr psbuncprbifjf`y ejy hb sbbf.
[bjrjmbfcfb `jusbs rbprcnu`tgvb tcxg`csgs gf sbxujmmy ejturbscws hy gfoghgtgfi sb`rbtgcf jfn rbmbjsb ca acmmg mb-stgeumjtgfi ocrecfb (APO) rbsumtgfi gf jrrbst ca prbcvumjtcrycvjrgjf acmmg`mb ejturjtgcf.
Behryctcxg`gty
MBPGCFP
g g g g m n g o n a mmg m g g n mm m
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Mbsgcfs gf pgis gf`munb cvjrgjf jtrcpoy jfn acmmg`umjr jtrbsgj, utbrgfb bnbej, `bmmumjr
oypbrtrcpoy gf jmm mjybrs ca tob utbrus, jfn j `ystg` jppbjrjf`b gf nbibfbrjtgvb
bfncebtrgjm imjfns. ^ob ejeejry imjfns socw nu`tjm oypbrpmjsgj jfn bpgtobmgjm
prcmgabrjtgcf. squjecus ebtjpmjsgj gs sbbf gf tob `brvgx jfn vjigfj.
NGJIFCPGP
Xbprcnu`tgvb pbracrejf`b gf tob obrn cr amc`d, `mgfg`jm sgifs, jfn ogstcry ca ngbt-
rbmjtbn c``urrbf`b.
@obeg`jm jfjmysgs ca suspb`t abbn acr zbjrjmbfcfb jfn `jrbaum bxjegfjtgcf carbprcnu`tgvb crijfs jt fb`rcpsy jrb rbqugrbn..
NGAABXBF^GJM NGJIFCPBP;
Xbprcnu`tgvb trj`t gfab`tgcfs jfn ctobr `jusbs ca gepjgrbn abrtgmgty su`o js
ngbtoymstgmhbstrcm gf tob ngbt ca ocusbn stc`d. Gf irjzgfi obrhgvcrbs, bspb`gjmmy sobbp,
tob pmjft bstrcibfs (bi, gscamjvcfbs jssc`gjtbn wgto sceb vjrgbtgbs ca suhtbrrjfbjf
jfn rbn `mcvbrs, jfn `cuebstjfs gf `brtjgf acnnbrs Tbi, jmajmajU) socumn hb `cfsgnbrbn.
^rbjtebft , @cftrcm jfn Ejfjibebft
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Rfmbss stc`d jrb sbvbrbmy cr `orcfg`jmmy jaab`tbn, usujmmy
rbprcnu`tgvb auf`tgcfs rb`cvbr jfn sgifs rbirbss :-> wd
jatbr gftjdb ca zbjrjmbfcfb stcps. Ejfjibebft ca swgfb wgto oypbrbstrcibfgse socumn
gf`munb `ojfigfi tob irjgf geebngjtbmy.
Jfgejms socumn hb trbjtbn syeptcejtg`jmmy acr vjigfjm
cr rb`tjm prcmjpsb jfn poysg`jm njejib tc bxtbrfjmibfgtjmgj.
Acr sbxujmmy ejturb scws wgto jfbstrus, cfb mC-ei ncsb
ca prcstjimjfngf A8j, cr twc 2-ei ncsbs cf su``bssgvb
njys, ojs `crrb`tbn jfbstrus `jusbn hy rbtjgfbn `crpcrj.
Jmajmaj jfn jmajmaj ebjm abn tc swgfb jt 82% ca tob rjtgcf
ejy rbnu`b jhscrptgcf jfn gf`rbjsb ab`jm bx`rbtgcf ca
zbjrjmbfcfb, hut togs gs catbf fct `cfsgnbrbn prj`tg`jm.
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^XG@OC^OB@BFBP
(ARPJXGC^C_G@CPGP)
^rg`octob`bfbs
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Jrb j ircup ca `mcsbmy rbmjtbn sb`cfnjry ebtjhcmg prcnu`ts ca
sbvbrjm ajegmgbs ca gepbrab`t, sjprcpoytg`, cr pmjft pjtocibfg` aufig
su`o jsAusjrgue, ^rg`octob`gue, Eyrctob`gue, @bpojmcspcrgue,
Ptj`oyhctrys,
^rg`ocnbsej, @ymgfnrc`jrpcf, jfn Qbrtg`gecfcspcrgue spp.
Cf tob hjsgs ca ecmb`umjr stru`turb, tob trg`octob`bfbs jrb
`mjssgagbn js
Fcfej`rc`y`mg` (bi, nbcxyfgvjmbfcm TNCFU cr vcegtcxgf, ^-8
tcxgf, ngj`btcxys`grpbfcm, (NJP) jfn ctobrs)
Ej`rc`y`mg` (sjtrjtcxgf, rcrgngf, vbrru`jrgf).
Ecst `ceecfmy acufn jfn stungbn jrb
NCF,cr vcegtcxgf, ^-8 tcxgf, (ECP^ @W^C^C_G@) jfn
ngj`btcxys`grpbfcm, (NJP)
Ogiomy tcxg` jt tob suh`bmmumjr, `bmmumjr, jfn crijfg` systbe mbvbm.
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^oby swgatmy pbfbtrjtb `bmm mgpgn hgmjybrs, tous jmmcwgfi j``bss tc
NFJ, XFJ, jfn `bmmumjr crijfbmmbs.
Gfoghgt prctbgf syftobsgs hy jaab`tgfi pcmyrghcscebs tc gftbrabrbwgto tob gfgtgjtgcf pojsb ca prctbgf syftobsgs.
Jt tob suh`bmmumjr mbvbm, tobsb tcxgfs gfoghgt prctbgf syftobsgs jfn
`cvjmbftmy hcfn tc sumaoynrym ircups.
^cxg`gty ca tob trg`octob`bfbs gs hjsbn cf ngrb`t `ytctcxg`gty jfn gscatbf rbabrrbn tc js j rjngcegebtg` baab`t (bi, hcfb ejrrcw
oypcpmjsgj, ijstrcbftbrgtgs, ngjrrobj, obecrrojibs).
^ob `utjfbcus `ytctcxg gty - j`utb, fb`rctgsgfi prc`bss wgto
egfgejm gfamjeejtgcf ca hcto tob bpgnbregs jfn nbregs.
Ptcejtgtgs, oypbrdbrjtcsgs wgto um`brjtgcf ca tob bscpojibjm pcrtgcf
ca tob ijstrg` eu`csj, jfn fb`rcsgs ca tob IG trj`t ojvb hbbf sbbf
jatbr gfibstgcf ca trg`octob`bfbs.
Geeufcsupprbssgvb
\cumtry jfn `jttmb jrb ecrb tcmbrjft ca trg`octob`bfbs
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\cumtry jfn `jttmb jrb ecrb tcmbrjft ca trg`octob`bfbs
tojf jrb \GIP - ecst su`bptghmb.
Fcfej`rc`y`mg` (bi, nbcxyfgvjmbfcm TNCFU cr vcegtcxgf,
^-8 tcxgf, ngj`btcxys`grpbfcm, (NJP) - ejgfmy prcnu`bn hy
Ausjrgue spcrctrg`ocgnbs ( ^8 jfn NJP)
A. rcsbue (NCF)
Mgpcpogmg` jibfts, jhscrhbn torcuio sdgf iut, pumecfjry
eu`csj
jaab`t rjpgnmy prcmgabrjtgfi tgssubs. Nc fct rbqugrb
ebtjhcmg` `cfvbrsgcf tc j`t, ufmgdb ctobr ey`ctcxgfs
^C_G@CNWFJEG@P
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^C_G@CNWFJEG@P
\ctbft gfoghgtcrs ca prctbgf syftobsgs 1
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Ptj`oyhctryctcxg`csgs;
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ocrsb, `jttmb, sobbp, pgis-jaab`tbn nub tc `cfsuepjtgcf ca ojy `cftjegfjtbn
wgto Ptj`oyhctrgs jtrj.
@cftrcm ca ^rg`octob`bfs
Pyeptcejtg` trbjtebft jfn abbngfi ca uf`cftjegfjtbn abbn
jrb rb`ceebfnbn.
Ptbrcgnjm jftg-soc`d jfn jftg-gfamjeejtcry jibfts, su`o js
ebtoymprbnfgscmcfb, prbnfgscmcfb, jfn nbxjebtojscfb,
ojvb hbbf usbn su``bssaummy gf bxpbrgebftjm trgjms.
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BXIC^GPE
BXIC^GPE
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BXIC^GPE
Mcfibst dfcwf ey`ctcxgf
^ogs wcrmnwgnb ngsbjsb ca ajre jfgejms rbsumts arce `cftgfubn
gfibstgcf ca s`mbrctgj ca tob pjrjsgtg` aufius @mjvg`bps purpurbj,
wog`o rbpmj`bs tob irjgf cr sbbn ca ryb jfn ctobr sejmm irjgfs cr
acrjib pmjfts, su`o js tob hrcebs, hmubirjssbs, jfn rybirjssbs.
^ob ojrn, hmj`d, bmcfijtbn s`mbrctgj ejy `cftjgf vjrygfi qujftgtgbs
ca brict jmdjmcgns, ca wog`o brictjegfb jfn bricfcvgfb
(bricebtrgfb) jrb pojrej`cmcig`jmmy ecst gepcrtjft.
@jttmb, pgis, sobbp, jfn pcumtry jrb gfvcmvbn gf spcrjng` cuthrbjds,
jfn ecst spb`gbs jrb sus`bptghmb
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^C_G@CNWFJEG@P
pjrtgjm jicfgst jfn jftjicfgst jt jmpoj
jnrbfbrig` rb`bptcrs gf vjs`umjr jfn ctobr
seccto eus`mbs
brictjegfb- sbrctbfbrig` jftjicfgst
bricebtrgfb- pctbft cxytc`g` j`tgcf
Ncpjegfbrig` jicfgst- gfoghgts prcmj`tgf
Brict `jusbs vjsc`cfstrg`tgcf hy ngrb`t j`tgcf cf tob rbpbjtbn
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ncsjibs gfkurb tob vjs`umjr bfnctobmgue.
Gfgtgjmmy rbnu`b hmccn amcw jfn bvbftujmmy mbjn tc `cepmbtb
stjsgs wgto tbregfjm fb`rcsgs ca tob bxtrbegtgbs nub tc
torcehcsgs.
J `cmn bfvgrcfebft prbngspcsbs tob bxtrbegtgbs tc ijfirbfb.
Brict ojs j pctbft cxytc`g` j`tgcf jfn jmsc `jusbs stgeumjtgcf
ca tob @FP, acmmcwbn hy nbprbssgcf.
Brict jmdjmcgns gfoghgt pgtugtjry rbmbjsb ca prcmj`tgf wgto ajgmurb
ca hcto ejeejry nbvbmcpebft gf mjtb ibstjtgcf jfn nbmjybn
gfgtgjtgcf ca egmd sb`rbtgcf, rbsumtgfi gf jijmj`tgj jt pjrturgtgcf.
@mgfg`jm Agfngfis jfn Mbsgcfs
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@jttmb-. Mjebfbss, tob agrst sgif, ejy jppbjr 8-1 wd cr ecrb jatbr gfgtgjm
gfibstgcf, nbpbfngfi cf tob `cf`bftrjtgcf ca jmdjmcgns gf tob brict jfn
tob qujftgty ca brict gf tob abbn.
Ogfnmgehs jrb jaab`tbn hbacrb acrbmgehs, hut tob bxtbft ca gfvcmvbebft
ca j mgeh jfn tob fuehbr ca mgehs jaab`tbn nbpbfns cf tob njgmy gftjdb
ca brict.
Hcny tbepbrjturb jfn pumsb jfn rbspgrjtgcf rjtbs jrb gf`rbjsbn.
Bpgnbeg` oypbrtobregj jfn oypbrsjmgvjtgcf ejy jmsc .
Pwbmmgfi jfn tbfnbrfbss ca tob abtmc`d kcgft jfn pjstbrf.
Ygtogf -: wd, sbfsjtgcf gs mcst gf tob jaab`tbn pjrt, jf gfnbftbn mgfb
jppbjrs jt tob mgegt ca fcrejm tgssub, jfn nry ijfirbfb jaab`ts ngstjm pjrt.
Cfb cr hcto `mjws cr pjrt ca mgehs up tc oc`d cr dfbb ejy hb smcuiobn.
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\E Mbsgcfs
`yjfctg` jfn ojrnbfbn sdgf gf jnvjf`bn
`jsbs.
Puh`utjfbcus obecrrojib jfn sceb bnbej
c``ur prcxgejm tc tob fb`rctg` jrbj.
Ngjifcsgs
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i
Ogstcry jfn @m Pi
Brict jmdjmcgns ejy hb bxtrj`tbn jfnnbtb`tbn gf suspb`t ircufn irjgf ebjms.
NN;
Gnbftg`jm sgifs jfn mbsgcfs ca mjebfbss, jfnsmcuiogfi ca tob occvbs jfn tgps ca bjrs jfn
tjgm, jrb sbbf gf abs`ub acct gf `jttmb irjzgfi gf
wgftbr cf tjmm abs`ub irjss gfab`tbn wgto jfbfncpoytb aufius
^rbjtebft jfn @cftrcm
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^rbjtebft jfn @cftrcm
Geebngjtb `ojfib tc jf brict-arbb ngbt
Rfnbr pjsturb abbngfi `cfngtgcfs, arbqubft irjzgfi cr
tcppgfi ca pjsturbs prcfb tc brict gfabstjtgcf nurgfi tob
sueebr ecftos rbnu`bs amcwbr-objn prcnu`tgcf jfn
obmps `cftrcm tob ngsbjsb.
Irjgf tojt `cftjgfs bvbf sejmm jecufts ca brict socumn
fct hb abn tc prbifjft cr mj`tjtgfi scws. Pyeptcejtg`, suppcrtgvb- sjmgfb purijtgvbs,
jftg`cfvumsjft, jftghgctg`s, dbbpgfi jfgejm wjre
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ABP@RB \CGPCFGFI
^jmm abs`ub (Abstu`j jrufngfj`bj)gs tob prbncegfjft pjsturb
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irjss - Abs`ub mjebfbss ojs hbbf rbpcrtbn
^ob `jusjtgvb tcxg` suhstjf`b ojs j`tgcfs sgegmjr tc tocsb
prcnu`bn hy s`mbrctgj ca @mjvg`bps purpurbj.
Bricvjmgfb jfn pbrjegfb jrb tob tcxgfs
^ob `mjvg`gpgtj`bcus bfncpoytb aufius J`rbecfgue
`cbfcpogjmue
Abs`ub sueebr tcxg`csgs gf `jttmb- pccr wbgiot ijgf, nb`r.
egmd prcnf, rcuio ojgr `cjt, sjmgvjtf, pccr rbprcn
pbracrejf`b, jijmj`tgj
Abs`ub acct- gf sobbp , `jttmb- c``urs gf wgftbr- mbsgcfs
sgegmjr tc ijfirbfcus brictgse
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ARECFGPGFP
Auecfgsgf ^cxg`csgs
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Bqugfb mbudcbf`bpojmcejmj`gj gs j ey`ctcxg` ngsbjsb catob @FP tojt jaab`ts ocrsbs, eumbs, jfn ncfdbys.
Jssc`gjtbn wgto tob abbngfi ca ecmny `crf (ejgzb), usujmmycvbr j pbrgcn ca sbvbrjm wbbds.
Auecfgsgfs jrb prcnu`bn prgejrgmy hy Ausjrgueecfgmgacreb jfn Aprcmgabrjtue.
@cfngtgcfs ajvcrgfi auecfgsgf prcnu`tgcf jppbjr tc
gf`munb j pbrgcn ca nrcuiot nurgfi tob ircwgfi sbjscf wgtosuhsbqubft `ccm, ecgst `cfngtgcfs nurgfi pcmmgfjtgcf jfndbrfbm acrejtgcf.
^orbb tcxgfs prcnu`bn hy tob aufig ojvb hbbf `mjssgagbn jsauecfgsgf H: (AH:), H8 (AH8), jfn H0 (AH0). AH0 gs rbmjtgvbmy
fcftcxg`. Ejkcr objmto baab`ts jrb chsbrvbn gf Bqugnjb jfn swgfb
@mgfgjm Pgifs
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jpjtoy, nrcwsgfbss, pojryfibjm pjrjmysgs, hmgfnfbss,`gr`mgfi, stjiibrgfi, jfn rb`uehbf`y.
G`tbrus ejy hb prbsbft ga tob mgvbr gs gfvcmvbn. ^ob `ojrj`tbrgstg` mbsgcf -mgqubaj`tgvb fb`rcsgs ca tob
wogtb ejttbr ca tob `brbhrue.
Obpjtg` fb`rcsgs sgegmjr tc tojt sbbf gf jamjtcxg`csgs.
Auecfgsgfs ojvb jmsc hbbf rbpcrtbn tc `jusb j`utbbpgnbeg`s ca ngsbjsb gf wbjfmgfi cr jnumt pgis,`ojrj`tbrgsbn hy pumecfjry bnbej jfnoynrctocrjx.
\cr`gfb pumecfjry bnbej (\\B) gs usujmmy jf j`utb,ajtjm ngsbjsb jfn jppbjrs tc hb `jusbn hypumecfjry oypbrtbfsgcf wgto trjfsunjtgcf ca amugnsgf tob tocrjx rbsumtgfi gf gftbrstgtgjm pumecfjry
^XBECXIBFP
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^XBECXIBFP
^rbecribf-prcnu`gfi aufig ircw cf j wgnb vjrgbty ca accnstuaas, gf`mungfi njgry
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cr irjgf-`cftjgfgfi prcnu`ts gftbfnbn acr ouejf `cfsueptgcf (b.i. `obbsbs
jfn pjstjs), stcrbn irjgfs jfn futs (b.i. pbjfuts jfn wjmfuts) jfn j fuehbr
ca acrjibs (b.i. mbiuebs jfn irjssbs) `cfsuebn hy mgvbstc`d spb`gbs,
Bvbf ijrhjib jfn `cepcst pgmbs `jf hb scur`bs ca trbecribfg` ey`ctcxgf
Jmtocuio j vjrgbty ca ngaabrbft aufig syftobsgzb gfncmb ngtbrpbfb ey`ctcxgfs
ojvgfi spb`gag` trbecribfg` baab`ts cf tob `bftrjm fbrvcus systbe (@FP)
rbecribfs prcnu`bn hy \bfg`gmmgue spp. (bspb`gjmmy pbfgtrbe J jfn
rcqubacrtgfb) - ecst `ceecfmy bf`cuftbrbn ca tobsb ey`ctcxgfs.
\bfgtrbe J gs j pctbft fburctcxgf wog`o `jusbs j syfnrceb `ojrj`tbrgzbn hysustjgfbn trbecrs jfn, jt ogio ncsbs, `cfvumsgcfs jfn nbjto gf mjhcrjtcry jfn
ajre jfgejms
7/22/2019 MYCOTOXINS IN ANIMAL HEALTH
89/103
PMJAXJEGFB
7/22/2019 MYCOTOXINS IN ANIMAL HEALTH
90/103
Jmdjmcgnjm ey`ctcxgf prcnu`bn hy tob aufius Xogzc`tcfgj
mbiuegfg`cmj tojt `jusbs prcausb sjmgvjtgcf (smchhbrs) gfjfgejms.
J `ceecf aufijm pjtocibf ca rbn `mcvbr (^rgacmgue prjtbfsb)
jfn `jusbs j syfnrceb dfcwf js hmj`d pjt`o ngsbjsb gf tobpmjft.
Gfibstgcf ca `mcvbr ojy `cftjgfgfi smjarjegfb `jusbs sjmgvjry
bpgscnbs tojt mjst arce sbvbrjm ocurs tc cvbr 0 njys gfruegfjfts jfn ocrsbs
Ngsbjsb gs socrt tbre jfn jfgejms ibfbrjmmy rb`cvbr wgtocut
trbjtebft
7/22/2019 MYCOTOXINS IN ANIMAL HEALTH
91/103
HJ@^BXGJM ^C_GFP
HJ@^BXGJM ^C_GFP
7/22/2019 MYCOTOXINS IN ANIMAL HEALTH
92/103
HJ@^BXGJM ^C_GFP
Jnvbrsb rbj`tgcfs sbbf gf jfgejms (prgejrgmy
ncis) gfibstgfi accns `cftjgfgfi prbacrebntcxgfs jfn/cr ircssmy `cftjegfjtbn wgto
hj`tbrgj.
Hj`tbrgjs ca @cf`brf Pjmecfbmmj spp.4 @mcstrgngue spp. 4
Bs`obrg`ogj `cmg; jfn Ptjpoymc`c``us spp.
(P. typogeurgue. P. jfjtue, P. `ocmbrjsugs, P.fbwpcrt. P. bftbtgngtgs.)
(@mcstrgngue hctumgfue, tbtjfg)
Hj`tbrgjm cxgfs
7/22/2019 MYCOTOXINS IN ANIMAL HEALTH
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Hj`tbrgjm cxgfs
Bftbrctcxgfs-B.`cmg, Qghrgc `ocmbrjb
Obecmytg`- Ptrbptc`c``us, Ptjpo.
Fburctcxgf-@m. hctumgfue, @m. tbtjfg
`ytctcxgfs- Ptrbptc, Ptjpo, @m. ngaag`gmb
Bfnctcxgfs- Jmm irje fbijtgvb hj`t
@mcstrgngue Ppp.
@m t gng a g
7/22/2019 MYCOTOXINS IN ANIMAL HEALTH
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@mcstrgngue pbrargfibfs;
Ppcrb-acregfi jfjbrchg` hj`gmmus. Objt rbsgstjft strjgfs H, @, N jrb
jssc`gjtbn wgto j`utb bftbrctcxbegj.
Xjpgn nrcp gf hmccn prbssurb, gftrjvjs`umjr stjsgs jfn torcehcsgs,
bmbvjtbn \@Q, `cfibstbn mgvbr jfn dgnfbys, jfn obecrrojig` fb`rcsgs ca
tob gftbstgfbs
@. hctumgfue;
Acufn gf jfy accn scur`b wgto j pO6>.2 \rcnu`bs j fburctcxgf, wog`o`jusbs amj``gn ectcr pjrjmysgs (rbspgrjtcry ngaag`umty, bx`bss sjmgvjtgcf,
jfn nbjto).
Fburctcxgf jnscrhs tc fbrvcus tgssubs, tobrbhy prbvbftgfi
j`btym`ocmgfb rbmbjsb jfn cr gts gfj`tgvjtgcf jt tob syfjptg` sgtbs.Qjrgjhmb sbfsgtgvgty jecfi spb`gbs;
Iugfbj pgis Bxtrbebmy sbfsgtgvb
^urdby Xbsgstjft 4 Ncis, @jts, jfn \gis Xbmjtgvbmy rbsgstjft
Ocrsbs, Egfds, jfn \cumtry Ecst `ceecfmy jaab`tbn
^rbjtebft
7/22/2019 MYCOTOXINS IN ANIMAL HEALTH
95/103
^rbjtebft
\cmyvjmbft jftctcxgf wgto jftghj`tbrgjms-`rystjmmgfb pbfg`gmmgf I scngue
amugn jfn bmb`trcmytb
ngbtjry nbag`gbf`y ga jfy socumn hb `crrb`tbn
^B^JFRP
7/22/2019 MYCOTOXINS IN ANIMAL HEALTH
96/103
Fburctcxgf- hy @m. tbtjfg ufnbr jfjbrchg` `cfntgcfs Ocrsb, ouejfs ecst sus`bptghmb
`jttmb, pgi, sobbp-mbss sus`.
Hgrn jrb rbmjtgvbmy rbsgstjft
tcxgf pcssbss prctbjsb j`tgvgty
hgfn tc ijfimgcsgnbs jt prbsyfjptg` gfoghgtcry ectcr fbrvb
bfngfis gf hrjgf stbe cr spgfjm `crn sbmb`tgvb `mbvjib ca prctbgf `cepcfbft ca syfjptg` vbsg`mbs,
syfjptchrbvgf
prbvbfts rbmbjsbca gfoghgtrcy fburctrjfsegttbr- Imy`gfb jfn
IJHJ togs rbsumts gf bx`bssgvb stgeumjtgcf ca spgfjm `crn mbjngfi tc
spjsecng` tcfg` `cftrj`tgcfs ca sdbmbtjm eus`mb- `jmmbn tbtjfy
Eus`umjr stgaafbss j``cepjfgbn hy eus`umjr trbecrs- m si.
Bx`gtbn hy bxt. stgeumg
Ngjifcsgs
7/22/2019 MYCOTOXINS IN ANIMAL HEALTH
97/103
Ngjifcsgs
Ogstcry jfn @m Pi Mjh agfngfis- sbrue tcxgf nbtb`tgcf
NN
Oypcejifbsbegj, bf`bpojmgtgs B`mjepsgj, stry`ofgfb pcgscfgfi
^rbjtebft
^btjfus jftgtcxgf(tcxcgn)- 0
7/22/2019 MYCOTOXINS IN ANIMAL HEALTH
98/103
@yjfchj`tbrgjm prcmgabrjtgcfs gf arbsowjtbr b`csystbes, jmsc dfcwf
js hmcces, `jf ojvb j sgifgag`jft gepj`t cf tob objmto ca jfgejms
jfn ouejfs mgvgfi gf cr usgfi tobsb systbes acr nrgfdgfi wjtbr
jfn/cr rb`rbjtgcfjm purpcsbs.
Jecfi tob 8
7/22/2019 MYCOTOXINS IN ANIMAL HEALTH
99/103
EG@XC@WP^GFP
7/22/2019 MYCOTOXINS IN ANIMAL HEALTH
100/103
\rcnu`bn hy sbvbrjm `yjfchj`tbrgj, gf`mungfi spb`gbs wgtogf
tob ibfbrj Eg`rc`ystgs, Jfjhjbfj, \mjfdtctorgx, Fcstc`,
Cs`gmmjtcrgj jfn Jfjhjbfcpsgs
@y`mg` obptjpbptgnbs tojt `jusb obpjtctcxg`csgs
Ppb`gag`jmmy tcxg` tc mgvbr, `jusgfi mgvbr bfmjribebft,
prcirbssgvb `bftrgmchumjr obpjtc`ytb rcufngfi, ngssc`gjtgcf
jfn fb`rcsgs.
JFJ^C_GFP
7/22/2019 MYCOTOXINS IN ANIMAL HEALTH
101/103
Ejgfmy prcnu`bn hy `yjfchj`tbrgj gf tob
Jfjhjbfj ibfus
Fburctcxgfs- ngvgnbn gftc
jfjtcxgf-j, ocecjfjtcxgf-j jfn jfjtcxgfj(s).
Jfjtcxgf-j gs pctbft `ocmgfbrig` jicfgst jt
fg`ctgfg` j`btym`ocmgfb rb`bptcrs gf fburcfs
jfn jt tob fburceus`umjr kuf`tgcfs
^rbjtebft ^obrb gs fc spb`gag` jftgnctb acr jfjtcxgf-j.
7/22/2019 MYCOTOXINS IN ANIMAL HEALTH
102/103
^obrb gs fc spb`gag` jftgnctb acr jfjtcxgf j.
Jnegfgstrjtgcf ca j`tgvjtbn `ojr`cjm ojs hbbf rb`ceebfnbn.
jrtgag`gjm rbspgrjtgcf ejy hb ca hbfbagt jmcfi wgtosuppcrtgvb`jrb.
Ppb`gag` ebjsurbs tc `cftrcm sbgzurbs gf`munb hbfzcngjzbpgfbs,
pobfchjrhgtjm cr pbftchjrhgtjm.
Gf jfy sbgzurgfi jfgejm, `cftrcm ca hcny tbepbrjturb gs jfgepcrtjft pjrt ca tob syeptcejtg` `jrb.
\rjmgncxgeb (8-\JE) gs fct jhmb tc rbj`tgvjtb tob gfoghgtbn
j`btym`ocmgfbstbrjsb jfn gs tobrbacrb fct rb`ceebfnbn
Jtrcpgfb socumn hb igvbf jt j tbst ncsb tc nbtbregfb gts
baag`j`y gf jfgejms wgto mgab-torbjtbfgfi `mgfg`jm sgifs. Jatbr
tob tbst ncsb, jtrcpgfb `jf hb igvbf rbpbjtbnmy
7/22/2019 MYCOTOXINS IN ANIMAL HEALTH
103/103
Pjxgtcxgfs jfn nbrgvbn acres hbmcfi tc tob ircup ca pjrjmytg`
sobmmagso tcxgfs jfn ojvb hbbf prcnu`bn hy j fuehbr ca
arbsowjtbr
`yjfchj`tbrgj, gf`mungfi Jpojfgzcebfcf amcs-jqujb,
@ymgfnrcspbrecpsgs rj`ghcrsdgg, Jfjhjfbj `gr`gfjmgs, Myfihyj
wcmmbg jfn \mjfdtctorgx sp.
Gf ouejfs, sjxgtcxgfs jrb jssc`gjtbn wgto tob nbvbmcpebft ca
j fburcmcig`jm ngsbjsb jatbr tob gfibstgcf ca sobmmagso
`cftjegfjtbn wgto sjxgtcxgfs