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Brand Names: CellCept . Description It is an immunosuppressive agents used to lower the body's natural immunity in patients who receive organ transplants.
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Mycophenolate MofetilMycophenolate Mofetil
Mshael AL-BargawiMshael AL-Bargawi
Brand Names:Brand Names:CellCeptCellCept . .
DescriptionIt is an immunosuppressive agents used to lower the body's natural immunity in patients who receive organ transplants.
CHEMICAL STRUCTRECHEMICAL STRUCTRE::
C23H31NOC23H31NO
Therapeutic uses: 1 _It used to prevent the body
rejection of a solid organ transplant such as:
-Kidney. - Heart .
-Liver. -Lunge and Pancreas .
2_In treatment of uveitis
3_In treatment of nephritis.
4_ In the treatment of several types of vasculitis .
5 _Treatment of psoriasis.
DOSE AND ADMINISTRAIONDOSE AND ADMINISTRAION::
**Orally :**Orally : (twice a day ) (twice a day )--Oral tabletOral tablet : : 500 500 mgmg . .-Oral capsule-Oral capsule : : 250 mg .250 mg .-Oral powder for suspension -Oral powder for suspension : : 200 mg/ml .200 mg/ml .**Intravenous:**Intravenous: 500 mg vial to be 500 mg vial to be
reconstituted in 14 ml of D5Wreconstituted in 14 ml of D5W . .
MECHANISM OF ACTION:
-MMF is a semisynthetic derivative of MPA.
-It is a potent reversible ,selective.
-Noncompetitive inhibitor of the enzyme inosine monophosphate dehydrogenase .
Blocking the de novo formation of GMP Deprivation of proliferation Tand B-cell of nucleic acid.
PHARMACOKINETICS:
-It used orally or I.V but the bioavailabilityafter oral application in general is rapid .-It is highly bound to plasma proteins .-It hydrolyzed to form (MPA), the activemetabolite, by gut wall , liver, peripheal tissues, and plasma esterases . -It is mainly metabolized in the liver and excretion by Kidney .
-
MAIN SIDE EFFEECTS: 1-In GIT : ( nausea, vomiting,
diarrhea,urinary tract infection, abdominal pain, loose bowel-movements and cramping).
2-Myelosuppression : including leukopenia , thrombocytopenia and anemia.
3 -bone marrow suppression. 4-peripheral edema.
5-Malignancy : like non-Hodgkin’s lymphomas .
CONTRAINDICATION:1-Pregnancy.
2-Breast-feeding .
3-Allergies :to mycophenolate or any othersubstances, such as food preservatives ordyes .4-Children .
5-Older adults .
DRUG INTERACTIONSDRUG INTERACTIONS::
Improves the actionImproves the actionReduced the actionReduced the actionCyclosporineCyclosporine magnesiummagnesium hydroxidehydroxide voriconazolevoriconazole Aluminium hydroxideAluminium hydroxide
steroidssteroids CholysteramineCholysteramine
calcineurin inhibitorscalcineurin inhibitors Oral contraceptivesOral contraceptives
FK506FK506tacrolimustacrolimus
AzathioprineAzathioprine
allopurinolallopurinol
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