Resources How To Skip to main content Skip to navigation About NCBI Accesskeys My NCBISign In PubMed US National Library of Medicine National Institutes of Health Search termSearch database All DatabasesPubMedProteinNucleotideGSSESTStructureGenomeAssemblyBioProjectBioSa mpleBioSystemsBooksConserved DomainsClonedbGaPdbVarEpigenomicsGeneGEO DataSetsGEO ProfilesHomoloGeneMeSHNCBI Web SiteNLM CatalogOMIAOMIMPMCPopSetProbeProtein ClustersPubChem BioAssayPubChem CompoundPubChem SubstancePubMed HealthSNPSRATaxonomyToolKitToolKitAllUniGeneUniS TS Search Advanced Help Result Filters Display Settings:AbstractSend to: Anaesthesia. 1993 Jul;48(7):626-8. Myalgia and biochemical changes following suxamethonium after induction of anaesthesia with thiopentone or propofol. Maddineni VR, Mirakhur RK, Cooper AR. Source Department of Anaesthetics, Queens's University of Belfast. Abstract The incidence and severity of muscle pains and changes in creatine kinase were assessed following administration of 1 mg.kg-1 suxamethonium either immediately or 2 min after induction of anaesthesia with propofol or thiopentone in patients undergoing elective dental and ophthalmic surgery. The incidence of muscle pains was 35 and 60% respectively in the groups given suxamethonium immediately and 2 min after propofol, and 35 and 55% when given immediately and 2 min after thiopentone, with no statistically significant differences among the groups. Creatine kinase levels increased in all the groups after operation with the least average increase in the group receiving suxamethonium immediately after propofol and the highest increase in the group receiving suxamethonium 2 min

after thiopentone. There was no correlation between the incidence and severity of fasciculations, muscle pains and changes in creatine kinase within or between the groups. It is concluded that neither the induction agent nor the time between the induction agent and suxamethonium administration has any significant influence on the incidence of muscle pains or creatine kinase elevation following suxamethonium. PMID: 8346781 [PubMed - indexed for MEDLINE] Publication Types, MeSH Terms, Substances LinkOut - more resources Supplemental Content Save items Add to Favorites View more options Related citations in PubMed A comparison of the effect of propofol or thiopentone on the incidence and severity of suxamethonium-induced myalgia. [Anaesth Intensive Care. 1994] Continuous propofol administration for suxamethonium-induced postoperative myalgia. [Anaesthesia. 1999] Effects of high-dose propofol on succinylcholine-induced fasciculations and myalgia. [Acta Anaesthesiol Scand. 2003] Review [Use of atracurium for the prevention of fasciculations and succinylcholine myalgia in athletes undergoing orthopedic surgery]. [Minerva Anestesiol. 1990] Review Suxamethonium myalgia. [Lancet. 1988] See reviews... See all... Cited by 2 PubMed Central articles Effect of magnesium sulfate with propofol induction of anesthesia on succinylcholine-induced fasciculations and myalgia. [J Anaesthesiol Clin Pharmacol....]

Remifentanil attenuates muscle fasciculations by succinylcholine. [Yonsei Med J. 2010] Related information Related Citations Compound Compound (MeSH Keyword) Substance Substance (MeSH Keyword) Cited in PMC Recent activity Clear Turn Off Myalgia and biochemical changes following suxamethonium after induction of anaes ... PubMed Differential effects of neuromuscular blocking agents on suxamethonium-induced f ... PubMed Calcium gluconate pretreatment for prevention of succinylcholine-induced myalgia ... PubMed Comparison of rocuronium and vecuronium pretreatment for prevention of fascicula ... PubMed Can lidocaine reduce succinylcholine induced postoperative myalgia? PubMed See more... You are here: NCBI > Literature > PubMed Write to the Help Desk Simple NCBI Directory Getting Started NCBI Education NCBI Help Manual

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