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Mutant Prion Protein Expression Causes Motor and Memory Deficits and Abnormal Sleep Patterns in a Transgenic Mouse Model Sara Dossena, Luca Imeri, Michela Mangieri, Anna Garofoli, Loris Ferrari, Assunta Senatore, Elena Restelli, Claudia Balducci, Fabio Fiordaliso, Monica Salio, Susanna Bianchi, Luana Fioriti, Michela Morbin, Alessandro Pincherle, Gabriella Marcon, Flavio Villani, Mirjana Carli, Fabrizio Tagliavini, Gianluigi Forloni, Roberto Chiesa Neuron Volume 60, Issue 4, Pages 598-609 (November 2008) DOI: 10.1016/j.neuron.2008.09.008 Copyright © 2008 Elsevier Inc. Terms and Conditions

Mutant Prion Protein Expression Causes Motor and Memory Deficits and Abnormal Sleep Patterns in a Transgenic Mouse Model Sara Dossena, Luca Imeri, Michela

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Page 1: Mutant Prion Protein Expression Causes Motor and Memory Deficits and Abnormal Sleep Patterns in a Transgenic Mouse Model Sara Dossena, Luca Imeri, Michela

Mutant Prion Protein Expression Causes Motor and Memory Deficits and Abnormal Sleep Patterns in a Transgenic Mouse Model 

Sara Dossena, Luca Imeri, Michela Mangieri, Anna Garofoli, Loris Ferrari, Assunta Senatore, Elena Restelli, Claudia Balducci, Fabio Fiordaliso, Monica Salio, Susanna Bianchi, Luana Fioriti, Michela Morbin, Alessandro Pincherle, Gabriella Marcon, Flavio Villani, Mirjana

Carli, Fabrizio Tagliavini, Gianluigi Forloni, Roberto Chiesa 

Neuron Volume 60, Issue 4, Pages 598-609 (November 2008)

DOI: 10.1016/j.neuron.2008.09.008

Copyright © 2008 Elsevier Inc. Terms and Conditions

Page 2: Mutant Prion Protein Expression Causes Motor and Memory Deficits and Abnormal Sleep Patterns in a Transgenic Mouse Model Sara Dossena, Luca Imeri, Michela

Figure 1

Neuron 2008 60, 598-609DOI: (10.1016/j.neuron.2008.09.008) Copyright © 2008 Elsevier Inc. Terms and Conditions

Page 3: Mutant Prion Protein Expression Causes Motor and Memory Deficits and Abnormal Sleep Patterns in a Transgenic Mouse Model Sara Dossena, Luca Imeri, Michela

Figure 2

Neuron 2008 60, 598-609DOI: (10.1016/j.neuron.2008.09.008) Copyright © 2008 Elsevier Inc. Terms and Conditions

Page 4: Mutant Prion Protein Expression Causes Motor and Memory Deficits and Abnormal Sleep Patterns in a Transgenic Mouse Model Sara Dossena, Luca Imeri, Michela

Figure 3

Neuron 2008 60, 598-609DOI: (10.1016/j.neuron.2008.09.008) Copyright © 2008 Elsevier Inc. Terms and Conditions

Page 5: Mutant Prion Protein Expression Causes Motor and Memory Deficits and Abnormal Sleep Patterns in a Transgenic Mouse Model Sara Dossena, Luca Imeri, Michela

Figure 4

Neuron 2008 60, 598-609DOI: (10.1016/j.neuron.2008.09.008) Copyright © 2008 Elsevier Inc. Terms and Conditions

Page 6: Mutant Prion Protein Expression Causes Motor and Memory Deficits and Abnormal Sleep Patterns in a Transgenic Mouse Model Sara Dossena, Luca Imeri, Michela

Figure 5

Neuron 2008 60, 598-609DOI: (10.1016/j.neuron.2008.09.008) Copyright © 2008 Elsevier Inc. Terms and Conditions

Page 7: Mutant Prion Protein Expression Causes Motor and Memory Deficits and Abnormal Sleep Patterns in a Transgenic Mouse Model Sara Dossena, Luca Imeri, Michela

Figure 6

Neuron 2008 60, 598-609DOI: (10.1016/j.neuron.2008.09.008) Copyright © 2008 Elsevier Inc. Terms and Conditions

Page 8: Mutant Prion Protein Expression Causes Motor and Memory Deficits and Abnormal Sleep Patterns in a Transgenic Mouse Model Sara Dossena, Luca Imeri, Michela

Figure 7

Neuron 2008 60, 598-609DOI: (10.1016/j.neuron.2008.09.008) Copyright © 2008 Elsevier Inc. Terms and Conditions

Page 9: Mutant Prion Protein Expression Causes Motor and Memory Deficits and Abnormal Sleep Patterns in a Transgenic Mouse Model Sara Dossena, Luca Imeri, Michela

Figure 8

Neuron 2008 60, 598-609DOI: (10.1016/j.neuron.2008.09.008) Copyright © 2008 Elsevier Inc. Terms and Conditions