Musc Ulos Ce Letal

8/18/2019 Musc Ulos Ce Letal

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MUSCULOSCELETAL

Dr. Dyah

Marianingrum,M.Kes,Sp.PA


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OUTLINES

BONES

Bone Moe!ing, "emoe!ing, an Pea# Bone Mass

Bone $ro%&h an De'e!opmen&

De'e!opmen&a! A(norma!i&ies in Bone Ce!!s, Ma&ri), anS&ru*&ure

MAL+O"MATIONS AND DISEASES CAUSED B DE+ECTS INNUCLEA" P"OTEINS AND T"ANSC"IPTION +ACTO"S

DISEASES CAUSED B DE+ECTS IN -O"MONES ANDSI$NAL T"ANSDUCTION MEC-ANISMS

DISEASES ASSOCIATED IT- DE+ECTS IN E/T"ACELLULA"ST"UCTU"AL P"OTEINS

Type 0 Co!!agen Diseases 1Os&eogenesis Imper2e*&a3

Diseases Asso*ia&e %i&h Mu&a&ions o2 Types 4, 5, 06,an 00 Co!!agen

DISEASES ASSOCIATED IT- DE+ECTS IN +OLDIN$ ANDDE$"ADATION O+ MAC"OMOLECULES

Mu*opo!ysa**harioses

DISEASES ASSOCIATED IT- DE+ECTS IN METABOLICPAT-AS 1EN7MES, ION C-ANNELS, AND

T"ANSPO"TE"S3

Os&eope&rosis

DISEASES ASSOCIATED IT- DEC"EASED BONE MASS

Os&eoporosis

DISEASES CAUSED B OSTEOCLAST DS+UNCTION

Page& Disease 1Os&ei&is De2ormans3

DISEASES ASSOCIATED IT- ABNO"MAL MINE"AL-OMEOSTASIS

"i*#e&s an Os&eoma!a*ia

-yperpara&hyroiism

"ena! Os&eoys&rophy+ra*&ures

Chap&er 48 9 Bones, :oin&s, an So2&9Tissue Tumors

Os&eone*rosis 1A'as*u!ar Ne*rosis3

In2e*&ions;Os&eomye!i&is

PO$ENIC OSTEOMELITIS

TUBE"CULOUS OSTEOMELITIS

SKELETAL SP-ILIS

Bone Tumors an Tumor9Li#e Lesions

BONE9+O"MIN$ TUMO"S

Os&eoma

Os&eoi Os&eoma an Os&eo(!as&oma

Os&eosar*oma

CA"TILA$E9+O"MIN$ TUMO"S

Os&eo*honromaChonromas

Chonro(!as&oma

Chonromy)oi +i(roma

Chonrosar*oma

+IB"OUS AND +IB"O9OSSEOUS TUMO"S

+i(rous Cor&i*a! De2e*& an Non9Ossi2ying +i(roma

+i(rous Dysp!asia

+i(rosar*oma


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B O N E S

Tu!ang 1sis&em s#e!e&a!3memi!i#i 2ungsi yang 'i&a!a!am #ehiupan>

homeos&asis minera!

&empa& e!emen4hema&opoie&i#

penun?ang me#anis upergera#an

me!inungi 'isera menen&u#an u#uran an

(en&u# &u(uh



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B O N E S

Tu!ang merupa#an>

► @Organ >

&.. ?ar. &u!ang,

&u!ang ra%an,!ema#, sumsum&u!ang,pem(.arah, sara2an ?ar. i#a& (rous

► @:aringan >

se*ara mi#ros#opi#&.. se!4 &u!ang.


Ana&omi -is&o!ogi


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B O N E S

Tu!ang 1sis&em s#e!e&a!3 >

s&ru#&ura!

pro&e#si

me&a(o!i#

Disusun o!eh 468 (uah&u!ang>

• Axial > *ranium, *o!umna'er&e(ra!is, &hora#s

• Appendicular >e#s&remi&as

Berasar#an (en&u#nya>

Tu!ang pan?ang

Tu!ang pipih

Tu!ang pene#

Iregu!er

Sesamoi

Berasar#an em(rio!ogi#>

Mem(ranous

Eno#onra!


Ana&omi -is&o!ogi


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B O N E SChap&er 48 9 Bones, :oin&s, an So2&9Tissue Tumors

Ana&omi -is&o!ogi


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B O N E S

Se*ara ma#ros#opi# &.. > Su(s&an&ia *ompa*&a > paa&,

!apisan !uar &u!ang, me!ipu&i6F sis&em s#e!e&a!. +ungsiu&ama (iome#ani#.

Su(s&an&ia spongiosa1&ra(e*u!ar, meu!!ary (one3 >(erongga, &erapa& p u?ung4&u!ang pan?ang.


Ana&omi -is&o!ogi

Ana&omy o2 (one. A s*hema&i* represen&a&ion o2 *or&i*a! an &ra(e*u!ar (one. The !ongi&uina! se*&ion 1 left)shows the vasculature entering the periosteum via the periosteal perforating arteries and coursing &hrough &he(one perpeni*u!ar &o &he !ong a)is in


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Ana&omi -is&o!ogi


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Ana&omi -is&o!ogi


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Ana&omi -is&o!ogi


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Ana&omi -is&o!ogi


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B O N E S

Se(agian (esar &eriri ari ma&ri#s organi# 1os&eoi3an minera! *a!*ium hyro)yapa&i&e mem(eri#e#ua&an an si2a& #eras paa &u!ang.

Tu!ang merupa#an ?aringan yg (ersi2a& inamis continuously resorbed, renewed, and remodeled >proses ini i!a#u#an se!4 &u!ang yg ia&ur o!ehse?um!ah 2a#&or &rans#ripsi, si&o#in, an 2a#&orper&um(uhan.


Ch 48 B : i S 2 Ti T


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B O N E S

:enis se!4 &u!ang >

Se! os&eoprogeni&or > se! &unas mesen#imp!uripo&en yang &er!e&a# i se#i&ar permu#aan&u!ang

Os&eo(!as an se! pe!apis permu#aan &er!e&a# ipermu#aan &u!ang > un&u# sin&esis, &ranspor& anmenyusun (anya# pro&ein ma&ri#s, ser&a memu!aiproses minera!isasi.

Os&eosi& merupa#an &rans2ormasi ari os&eo(!asyg &e!ah i#e!i!ingi eposi& ma&ri#s organi#.

Os&eo#!as > se! yg (erperan meresorpsi &u!ang.


Ch & 48 B : i & S 2& Ti T


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+igure 4890 Bone *e!!s an &heir in&erre!a&e a*&i'i&ies. -ormones, *y&o#ines, gro%&h 2a*&ors, an signa!9&ransu*ingmo!e*u!es are #ey in &heir 2orma&ion an ma&ura&ion, an a!!o% *ommuni*a&ion (e&%een os&eo(!as&s an os&eo*!as&s.Bone resorp&ion an 2orma&ion in remoe!ing are *oup!e pro*esses &ha& are *on&ro!!e (y sys&emi* 2a*&ors an !o*a!

*y&o#ines, some o2 %hi*h are eposi&e in &he (one ma&ri). BMP, (one morphogeni* pro&einH L"P=8, LDL re*ep&orre!a&e pro&eins an 8.

Ch & 48 B : i & S 2& Ti T


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+igure 4894 A, A*&i'e os&eo(!as&s syn&hesiJing (one ma&ri). The surrouning spin!e *e!!s represen& os&eoprogeni&or*e!!s. B, T%o os&eo*!as&s resor(ing (one.

Chap&er 48 Bones :oin&s an So2& Tissue Tumors


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Bone Moe!ing, "emoe!ing, Pea# Bone Mass

Se#umpu!an os&eosi&, os&eo(!as an os&eo#!as (e#er?a se*ara&erpau mengon&ro! pem(en&u#an an resorpsi &u!ang uni&

2ungsiona! > (asi* mu!&i*e!!u!ar uni& 1BMU3.

Paa a%a! #ehiupan, saa& &u!ang &um(uh an mem(esar1moe!ing3 pem(en&u#an &u!ang preominan.

Saa& &u!ang &e!ah men*apai ma&uri&as, penguraian anpem(aruan &u!ang yg (erperan u main&enan*e > remoe!ing

#emung#inan imu!ai i &empa&4 yg menga!ami 2a&igue anmi*roamage

paa orang e%asa, se#i&ar 0 ?u&a BMU a#&i2 se&iap saa&

me!a#u#an remoe!ing a&au menggan&i 06F &u!ang se&iap&ahun.

@Pea# (one mass &er*apai paa usia e%asa mua se&e!ah

(erhen&inya per&um(uhan &u!ang




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Bone Moe!ing, "emoe!ing, Pea# Bone Mass

@Pea# (one mass &er*apai paa usia e%asa mua se&e!ah(erhen&inya per&um(uhan &u!ang

i&en&u#an o!eh (er(agai 2a#&or > po!imorsme resep&or 'i&amin D an L"P=8

nu&risi

a#&i&as si#

usia

s&a&us hormona!

se?a# a%a! e#ae #eempa& > resorpsi 2ormasi penurunan massa &u!ang &erus9menerus.




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Bone $ro%&h De'e!opmen&Chap&er 48 9 Bones, :oin&s, an So2&9Tissue Tumors



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Bone $ro%&h De'e!opmen&Chap&er 48 9 Bones, :oin&s, an So2&9Tissue Tumors

+igure 489

A*&i'e gro%&h p!a&e %i&h ongoingen*honra! ossi*a&ion.

0, "eser'e Jone.

4, 7one o2 pro!i2era&ion.

, 7one o2 hyper&rophy.

, 7one o2 minera!iJa&ion.

, Primary spongiosa.


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SO+T TISSUE


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Diagnosa


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So2& &issue &umor


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Lymphangioma

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Musc Ulos Ce Letal