Murphy, James M. - CV · CURRICULUM VITAE James M. Murphy Associate Dean for Research and Graduate Education Dean’s Office, LD222 School of Science, IUPUI and Professor of Psychology

James M. Murphy 1 05/09 CURRICULUM VITAE James M. Murphy

Associate Dean for Research and Graduate Education Dean’s Office, LD222

School of Science, IUPUI

and

Professor of Psychology Department of Psychology, LD124

Psychobiology Program School of Science, IUPUI

402 North Blackford Street Indianapolis, IN 46202-3275

Phone: (317) 274-6762 Fax: (317) 274-6756

e-mail: [email protected]

and

Institute of Psychiatric Research, PR103

Indiana University School of Medicine, IUPUI 791 Union Drive

Indianapolis, IN 46202-4887

Phone: (317) 278-0910 Fax: (317) 274-1365

James M. Murphy 2 TABLE OF CONTENTS Page Appointments and Employment History.………………………………………………………..….. 3 Education and Degrees………………………………………………………………………………. 4 Teaching Experience........................................................................................…………… 4 Graduate Program Student Committees.............................................................………………. 5-6 Postdoctoral Supervision..................................................................................…………………. 6 Service Committees and Standing Positions........................................................……………… 7 Professional Society Memberships and Services.................................................……………… 8 Honors, Fellowships and Awards......................................................................………………… 9 Grants Funded and Completed ..........................................................................………………. 10-11 Current Grants …………………………………………..........................................……………… 11 Full-Length Publications and Book Chapters.......................................................……………… 12-20 Manuscripts In Press..........................................................................................………………… 21 Manuscripts Submitted for Publication or Under Revision......................................……………. 21 Published Abstracts and Presentations at National and International Meetings........…………. 22-38

James M. Murphy 3 Appointments and Employment History

2008-present Associate Dean for Research and Graduate Education School of Science,

Indiana University Purdue University at Indianapolis

1994-present Professor of Psychology Department of Psychology, Purdue School of Science Indiana University Purdue University at Indianapolis

1985-present Faculty, Program in Medical Neuroscience

Indiana University School of Medicine, Indianapolis

1989-1994 Associate Professor of Psychology Department of Psychology, Purdue School of Science Indiana University-Purdue University at Indianapolis

1985-1989 Assistant Professor (part-time)

Department of Psychology, Purdue School of Science Indiana University Purdue University at Indianapolis

1985-1989 Assistant Scientist of Neurobiology

Medical Neurobiology Program Indiana University School of Medicine, Indianapolis

1982-1985 Instructor (part-time)

Department of Psychology, Purdue School of Science Indiana University Purdue University at Indianapolis

1979-1985 Research Associate in Psychiatry

Institute of Psychiatric Research, Department of Psychiatry Indiana University School of Medicine, Indianapolis

1977-1979 Visiting Assistant Professor

Department of Psychology University of Virginia, Charlottesville, VA

James M. Murphy 4 Education and Degrees B.A. (1971) Psychology, Edinboro University of Pennsylvania. Senior research paper: Failure to find

operant escape from non-contingent positive brain stimulation in rats. M.A. (1974) Experimental Psychology, Bowling Green State University, OH. Masters Thesis Title: Rate of

central nervous system maturation and the development of long-term memory in neonatal mice. Ph.D. (1978) Experimental Psychology, concentration in Psychobiology, Bowling Green State University,

OH. Ph.D. Dissertation Title: The role of catecholamines in the mediation of starvation- and amphetamine-induced locomotor arousal in mice.

Teaching Experience

Department of Psychology, Purdue School of Science, Indiana University-Purdue University at Indianapolis

Laboratory courses Introductory Laboratory in Psychology Laboratory in Motivation Laboratory in Learning Laboratory in Physiological Psychology

Lecture courses

Undergraduate Introductory Psychology as a Biological Science Learning Drugs and Behavior Behavioral Neuroscience/Physiological Psychology Graduate Behavioral Neuroscience/Physiological Psychology Psychobiology of Learning and Motivation Drugs of Abuse and Addictive Behavior Psychopharmacology

Mentor courses Honors Independent Study Honors Research Readings and Research in Psychology

Medical Neuroscience Program and Department of Psychiatry Indiana University School of Medicine

Neurobiology for Psychiatry Residents (lectures on Neurochemistry, Neuroanatomy and Neurobiology of Alcoholism) Methods in Cell and Neurobiology (lectures on HPLC Theory and Methodology) Assisted in Supervision of several Medical Student Research Rotations Institute of Psychiatric Research

James M. Murphy 5 Graduate Program Student Committees

Carla Trusty-Smith, M.S. committee member; Differences in laboratory measures of biological consequences in Type I and Type II alcoholism: Validating evidence for the Cloninger typology. Department of Psychology, IUPUI. Awarded December 1990.

Lisa Ehrman, Ph.D. preliminary advisory committee member; Department of Psychology, IUPUI. 199 Eric A. Engleman, Ph.D. committee member; Serotonin receptor subtypes and brain regions associated

with operant response suppression in an animal model of depression. Program in Medical Neurobiology, Indiana University School of Medicine, Awarded December 1992.

Gregory J. Gatto, Ph.D. committee member; Reward-relevant actions of alcohol in selectively bred lines of rats. Program in Medical Neurobiology, Indiana University School of Medicine, Awarded December 1992.

Sue C. Spaulding, M.S. committee member; The effects of HIV infection on neuropsychological test performance: A quantitative review. Department of Psychology, IUPUI, July, 1993.

Robert L. Hewitt, M.S. committee member; Tolerance development to the ethanol suppressant effects of the benzodiazepine inverse agonist RO19-4603, in alcohol preferring (P) rats. Department of Psychology, IUPUI, May, 1994.

Michael Gibbs, M.S. advisory committee member; Program in Medical Neurobiology, Indiana University School of Medicine.

Robert Kohl, Ph.D. advisory committee member; Program in Medical Neurobiology, Indiana University School of Medicine.

Carrie Jones, Ph.D. preliminary examination committee member; Program in Medical Neurobiology, Indiana University School of Medicine.

Simon N. Katner, Ph.D. committee chair and advisory committee chair; Program in Medical Neurobiology, Indiana University School of Medicine,1995.

Paul McKinley, M.S. committee member; M.S. Degree awarded posthumously, Psychobiology Program, Department of Psychology, IUPUI, 1998.

Jeffrey Broome, M.S. committee member, Program in Medical Neurobiology, Indiana University School of Medicine, Glial cell line-derived neurotrophic factor protects midbrain dopamine neurons from the lethal action of the weaver gene: A quantitative immunocytochemical study. January 1999.

Stephanie Rock, Ph.D. committee co-chair; Psychobiology Program, Department of Psychology, IUPUI, Ethanol and cocaine interactive effects on local cerebral glucose utilization (LCGU). April 1999.

Jason Katner, M.S. committee chair, Psychobiology Program, Department of Psychology, IUPUI, completed.

Jennifer Learn, Ph.D. Preliminary and advisory committee and Ph.D. dissertation committee member; Program in Medical Neurobiology, Indiana University School of Medicine, completed.

Robert Sahr, Ph.D. advisory committee member; Program in Medical Neurobiology, Indiana University School of Medicine, completed.

Daniel G. Smith, Ph.D committee chair; Psychobiology Program, Department of Psychology, IUPUI, completed, May 2002.

Roberto I. Melendez, Ph.D. preliminary advisory committee chair; Psychobiology Program, Department of Psychology, IUPUI, completed.

Roberto I. Melendez, Ph.D. committee chair; Psychobiology Program, Department of Psychology, IUPUI, Completed.

Eric Claus, M.S. thesis committee member; Program in Clinical Rehabilitation, Department of Psychology, IUPUI, in progress.

Alexis Behm, M.S. thesis committee chair. Program in Psychobiology, Department of Psychology, IUPUI, completed. Preliminary qualification committee chair, in progress.

Christine Fontinella, Ph.D. Preliminary and advisory committee, Program in Medical Neurobiology, Indiana University School of Medicine.

Katrina Foster. Ph.D. preliminary qualification committee member and dissertation committee member; Psychobiology Program, Department of Psychology, IUPUI, completed.

Nicholas Gilpin, Ph.D. committee chair; Program in Psychobiology, Department of Psychology, IUPUI, completed. Preliminary qualification committee, completed. Ph.D. dissertation committee, completed December 2005

Lathan Hardy, M.S. thesis committee member; Program in Psychobiology, Department of Psychology, IUPUI, completed.

James M. Murphy 6

James E. Woods, II. Ph.D. preliminary examination advisory committee and dissertation committee member; Psychobiology Program, Department of Psychology, IUPUI, Completed.

Kelly Knopp, Ph.D. Preliminary and advisory committee, Program in Medical Neuroscience, Indiana University School of Medicine, Completed. Dissertation committee member,completed

Vanessa Barth. Ph.D. Program in Medical Neuroscience, Indiana University School of Medicine, advisory committee, completed. Dissertation committee member,completed

Michelle Carroll, Ph.D. committee member; Program in Psychobiology, Department of Psychology, IUPUI, completed; Preliminary examination advisory committee chair, completed. Dissertation committee chair, in progress.

Amy Kostrzewa, Ph.D. advisory committee member, Program in Medical Neuroscience, Indiana University School of Medicine, in progress. Preliminary qualification committee, completed. Dissertation member, in progress.

Kelle Franklin, Ph.D. committee chair; Program in Psychobiology, Department of Psychology, IUPUI, completed. Dissertation committee chair, in progress

Scott Oster, Ph.D. committee chair; Program in Psychobiology, Department of Psychology, IUPUI, completed; Dissertation committee chair, in progress

Jamie Toalston, Ph.D. committee chair; Program in Psychobiology, Department of Psychology, IUPUI, completed; Dissertation committee chair, in progress

Dennise Garzon, M.S. thesis committee member; Program in Psychobiology, Department of Psychology, IUPUI, completed.

William Eiler, M.S. thesis committee member; Program in Psychobiology, Department of Psychology, IUPUI, completed; Dissertation committee chair, in progress

Megan Bertholomy, M.S. thesis committee chair; Program in Psychobiology, Department of Psychology, IUPUI, in progress

Heather Musselman, M.S. thesis committee member; Program in Psychobiology, Department of Psychology, IUPUI, in progress

Alexis Green, M.S. thesis committee member; Program in Psychobiology, Department of Psychology, IUPUI, completed; Preliminary examination advisory committee member, completed. Dissertation committee member, in progress.

Angela Henderson, M.S. thesis committee member; Program in Psychobiology, Department of Psychology, IUPUI, in progress

Postdoctoral Supervision

Previous Dr. Andrew D. Levy, Postdoctoral NIAAA Training Fellow Dr. Robert B. Stewart, Postdoctoral Research Associate in Medicine Dr. Wanda Dyr, Visiting Polish Scientist Dr. Jack K. Chamberlain, Postdoctoral NIAAA Training Fellow Dr. David McKinzie, Postdoctoral NIAAA Training Fellow Dr. Satoshi Ikemoto, Postdoctoral Research Associate in Psychiatry Dr. Karen Nowak, Postdoctoral NIAAA Training Fellow Dr. Karen Nowak, Research Associate in Psychiatry Dr. Eric Engleman, Research Associate in Psychiatry Dr. Ying Zhang, Research Associate in Psychology and Psychiatry Dr. Nancy Badia-Elder, Assistant Scientist in Psychology

James M. Murphy 7 Service Committees and Standing Positions

Department of Psychology, School of Science, IUPUI Ad Hoc Grant Merit Review Committee, Chair (Fall 2001-Spring 2002) Ad Hoc Introductory Textbook Selection Committee, Chair (Fall 1989-Spring 1990) Ad Hoc Psychology Chair Search and Screen Committee (Fall 1990-Spring 1991) Ad Hoc Psychology Grant Merit Committee (Fall 2001-Spring 2002) Animal Care Supervisor (Fall 1989-Summer 1998) Chair=s Council (Summer 1995-Summer 1998) Departmental Space Committee, Chair (Fall 1997-Summer 1998) Director of Psychobiology of Addictions Program (Summer 1993-Summer1998;Fall 2001-Summer 2008) Director of Graduate Studies (Summer 1992-Summer 1993) Executive Committee (Fall 1989-Summer 1991; Fall 2004-present) Faculty Evaluation Committee (Summer 1995-Summer 1998; Chair Summer 1996-Fall 1998) Graduate Goals Committee (Fall 1994) Promotion and Tenure Committee (Fall 1994-Summer 1998; Fall 2000-Fall 2002; Fall 2005-present) Psychobiology Committee (Fall 1993-Present) Search and Screen Committee for Experimental Psychobiology Program (Fall 1991-Spring 1993) Undergraduate Committee (Fall 1989-Fall 1991)

School of Science, IUPUI Animal Facility Budget Committee (Chair, Fall 2000-Spring 2005; Summer 2008-present) Animal Facility Space Committee (Chair, Fall 2000- Spring 2005-present) Center for Therapeutic Behavioral Neuroscience (Member, Board of directors, Spring 2003) Department of Geology, Promotion and Tenure Committee (Fall 1996-Spring 2004) Institutional Animal Care and Use Committee (member Fall 1989-Spring 2005; Chair, Summer 2000-

Spring 2005) Nominations and Awards Committee (member Fall 1990-Spring 1994; Chair, Fall 2000-Spring 2001

and Fall 2006 – Spring 2007) Promotion and Tenure Area Committee (Fall 1994-Spring 1999; Fall 2001-Spring 2002) School of Science Research Committee (member Fall 2005-Summer 2008; Chair Summer 2008-present) School of Science and School of Engineering & Technology joint building committee chair; (Fall 2008-present) Teaching Committee (Fall 1989-Spring 1990)

School of Medicine, IUPUI

School of Medicine, Laboratory Animal Resource Advisory Committee (Spring 1997-present) Animal Laboratory Task Force (Fall 2003-Fall 2004)

Institute of Psychiatric Research and Medical Neurobiology Program, School of Medicine, IUPUI

Coordinator: Institute of Psychiatric Research In-House Research Seminar Series (Fall 1988-Spring 1993) Department of Psychiatry Mentor Committees (3 faculty; various dates)

University, IUPUI

Institutional Animal Care and Use Committee (Fall 1989-Fall 1992) Budgetary Affairs Committee (Summer 1990-Summer 1994) Faculty Board of Review (Spring 1990-Spring 1992) Nominations Committee (Fall 1991-Summer 1993) Tenure and Promotion Committee (Fall 1994-Spring 1995) University Faculty Council (Fall 1991-Summer 1993) Evaluation Committee, Dean of Science (Fall 1995-Spring 1996)

James M. Murphy 8 Professional Society Memberships

American Association for the Advancement of Science (p American Psychological Society Indiana Chapter of Society for Neuroscience International Brain Research Organization International Society for Biomedical Research on Alcoholism Midwestern Psychological Association Research Society on Alcoholism Sigma Xi Society for Neuroscience

Professional Journal Referee Services

Alcohol Alcohol & Alcoholism Alcoholism: Clinical and Experimental Research Behavioral Teratology and Toxicology Brain Research Brain Research Bulletin Drug and Alcohol Dependence Journal of Neurochemistry Journal of Pharmacology and Experimental Therapeutics Life Sciences Molecular Therapy Neuropsychopharmacology Pharmacology Biochemistry and Behavior Physiology and Behavior Proceedings of the National Academy of Sciences USA

Professional Grant Review Services

National Science Foundation, Washington, D.C., Ad hoc reviewer Veterans Administration Medical Center, Indianapolis, IN, Ad hoc reviewer Medical Research Council of Canada, Ad hoc reviewer NIH, National Institute on Alcohol Abuse and Alcoholism, Special Emphasis Panel, March 7, 1997 NIH, National Institute on Alcohol Abuse and Alcoholism, Small Business Innovation Research Grants,

March 2, 1998 NIH, National Institute on Alcohol Abuse and Alcoholism, Special Emphasis Panel, March 3, 1998 NIH, National Institute on Alcohol Abuse and Alcoholism, Special Emphasis Panel, October 30, 1998 NIH, National Institute on Alcohol Abuse and Alcoholism, Special Emphasis Panel, August 10, 1999 National Institute on Alcohol Abuse and Alcoholism, Small Business Innovation Research Grants,

January 13, 2000 NIH, National Institute on Alcohol Abuse and Alcoholism, Special Emphasis Panel, April 24-26, 2000 Veterans Administration, Ad hoc merit review, 2000. NIH, National Institute on Alcohol Abuse and Alcoholism, Small Business Innovation Research Grants,

November 1, 2000 NIH, National Institute on Alcohol Abuse and Alcoholism, Ad hoc reviews, November 8, 2004 NIH, National Institute on Alcohol Abuse and Alcoholism, Ad hoc reviews, Development Center P20

reviews, May 30, 2007 NIH, National Institute on Alcohol Abuse and Alcoholism, Ad hoc reviews, NAL study section reviews,

October 11, 2007 Other Professional Services

President of Indianapolis Chapter of Society for Neuroscience. Term: May 1993-May 1995 Elections Committee, Research Society on Alcoholism, Spring 2000-Spring 2002

James M. Murphy 9 Honors, Fellowships and Awards

Summa Cum Laude (B.A.) University Fellowship, 1973-1974; 1975-1976 Teaching Fellowship, 1974-1975 Bowling Green State University Distinguished Dissertation Award, 1978 Faculty Research Award, School of Science, IUPUI, 1994 Service Award, School of Science, IUPUI, 2000 School of Science, IUPUI, Special Service Recognition, Fall 2005

James M. Murphy 10 Grants Funded (Completed)

Li, T.-K., Lumeng, L., McBride, W.J., Waller, M.B., and Murphy, J.M. (Co-I). Biochemistry of alcohol drinking behavior and alcoholism, PHS RO1 AA03243, National Institute on Alcohol Abuse and Alcoholism; Funded 7/1/83-6/30/88.

Richter, J.A., Simon, J.R., McBride, W.J., Murphy, J.M., (Co-I), Nurnberger, J.I., Jr., and Shekhar, A.

Spectrophotometer for IPR. Indiana University School of Medicine Grant-in-Aid. 1985.

Li, T.-K., Lumeng, L., McBride, W.J., Murphy, J.M., (Co-I), Froehlich, J., and Morzorati, S. Biochemistry of alcohol drinking behavior and alcoholism, PHS RO1 AA03243, National Institute on Alcohol Abuse and Alcoholism; Funded 7/1/88-6/30/90.

Li, T.-K., McBride, W.J., Morzorati, S., Murphy, J.M., (Co-I), and Stewart, R.B. Basic studies on animal

models of alcoholism. Regenstrief Foundation, Indianapolis, IN. Annual competitive renewal funding 1985-1992; last funded period 7/1/91-6/30/92.

Lumeng, L. (PI), Murphy, J.M. (Preceptor). Training grant on genetic aspects of alcoholism. National

Institute on Alcohol Abuse and Alcoholism; Funded 7/1/90-6/30/00.

Murphy, J.M. (PI). Blood Platelet Serotonin in Alcohol-Preferring and -Nonpreferring Rats and the Effects of Ethanol. Pilot Project: Center on Genetic Determinants of Alcohol Ingestion, (Center PI, Dr. T.-K. Li), PHS P50 AA07611. National Institute on Alcohol Abuse and Alcoholism. Pilot Project: 9/1/88-11/30/90.

McBride, W.J., and Murphy, J.M., (Co-I). Preclinical testing of pharmacological agents for potential use

in the treatment of alcohol abuse. Lilly Research Laboratories, Funding approved 5/1/92-6/30/93.

Murphy, J.M., (PI), Stewart, R.B., and Brush, F.R. Behavior and behavioral pharmacology component of program project: Neurobiology and genetics of alcohol-seeking behavior. (Program Project PI, Dr. T.-K. Li), National Institute on Alcohol Abuse and Alcoholism; Funded 7/1/90-6/30/95.

McBride, W.J., and Murphy, J.M. Neurochemistry component of program project: Neurobiology and

genetics of alcohol-seeking behavior. (Program Project PI, Dr. T.-K. Li), National Institute on Alcohol Abuse and Alcoholism; Funded 7/1/90-6/30/95.

Bosron, W.F., Dean, R.A., and Murphy, J.M., (Co-I). Enzymology and regulation of cocaine ester

metabolism. National Institute on Drug Abuse. Funded 8/1/92-7/30/95.

McBride, W.J., and Murphy, J.M., (Co-PI). CNS sites of rewarding actions of alcohol. National Institute on Alcohol Abuse and Alcoholism; Funded 4/1/93-3/31/96.

Murphy, J.M., Zhou, F.C., and McKinzie, D.L. Influence of developmental environment on behavior of

selectively bred alcohol-preferring and -nonpreferring rats. Indiana Alcohol Research Pilot Project Grant. Funded 7/1/94-11/30/95.

McBride, W.J., Murphy, J.M., (Co-I), Li, T.-K., Lumeng, L., and Ikemoto, S. Neural basis of the alcohol

deprivation effect. National Institute on Alcohol Abuse and Alcoholism; Funded 7/1/97-6/30/00,

Murphy, J.M., (PI), and Bowers, B. Innate stress reactivity and high alcohol preference. Pilot project funded through the Indiana Alcohol Research Center. National Institute on Alcohol Abuse and Alcoholism; Funded 12/1/98-11/30/00; $50,000 annual direct costs.

Murphy, J.M., (co-mentor), and McBride, W.J. National Research Service Award for Daniel G. Smith.

Local cerebral glucose utilization and alcohol relapse. National Institute on Alcohol Abuse and Alcoholism; Funded 8/1/98-7/30/01; $21,800 annual direct costs

James M. Murphy 11

Murphy, J.M., (component PI) Substrates of disinhibition and alcohol preference. Component of the Indiana Alcohol Research Center. National Institute on Alcohol Abuse and Alcoholism; Funded 12/1/97-11/30/02; $108,000 annual direct costs

McBride, W.J., (PI) Murphy, J.M. (Co-I). CNS Sites for the Rewarding Actions of Alcohol. National

Institute of Alcohol Abuse and Alcoholism, Funded 04/01/00-03/31/05; $199,561 annual direct costs

Murphy, J.M., (PI), and Engleman, E.A. CNS sites mediating alcohol drinking behavior. National Institute on Alcohol Abuse and Alcoholism; Funded 8/1/95-6/30/05; $175,000 annual direct costs

Stewart, R.B., Lumeng, L., Morzorati, S., Murphy, J.M. (Co-I), and Badia-Elder, N. Alcohol tolerance in

rat lines selected for preference. National Institute on Alcohol Abuse and Alcoholism; Funded 7/1/00-6/30/05 (in “no-cost” extension); $250,000 annual direct costs

McBride, W.J., Murphy, J.M., (Co-I), Li, T.-K., Lumeng, L., Thielen, R., and Rodd-Henricks. Neural basis

of the alcohol deprivation effect. National Institute on Alcohol Abuse and Alcoholism; Funded 4/1/01-3/31/06; $200,000 annual direct costs

Badia-Elder, N.E., Stewart, R.B., Li, T.-K., Murphy, J.M., (Co-I), and Engleman, E.A. Neuropeptide Y

and alcohol related behavior. National Institute on Alcohol Abuse and Alcoholism; Funded, 8/1/01-6/30/06; $175,000 annual direct costs

McBride W.J. (component PI) and Murphy, J.M. (Co-I) (component of Crabb, D.W.; PI, Indiana Alcohol

Research Center on Genetic Determinants of Alcohol Ingestion); component “Animal Genetics Component.” National Institute on Alcohol Abuse and Alcoholism; Funded, 12/1/02-11/30/07; $180,950 component annual direct costs

McBride, W.J., and Murphy, J.M., (Co-I). Neurobiological Factors in Adolescent Alcohol Drinking. NIH, National Institute on Alcohol Abuse and Alcoholism; Funded 4/2001 - 04/12/05; $225,000 annual direct costs

Grants Funded (Current)

Murphy, J.M. (PI) Activating effects of ethanol in selectively bred rats. NIH, National Institute on Alcohol Abuse and Alcoholism; Funded 09/26/2005 - 06/30/2010; $140,000 average annual direct costs

Murphy, J.M., (PI), and Engleman, E.A. CNS sites mediating alcohol drinking behavior. NIH, National

Institute on Alcohol Abuse and Alcoholism; Funded 07/01/2007 - 06/30/2011; $191,250 annual direct costs

McBride, W.J. (PI) (Murphy, J.M., serve as preceptor). Training grant on genetic aspects of alcoholism.

NIH, National Institute on Alcohol Abuse and Alcoholism; Funded 7/1/95-6/30/10.

James M. Murphy 12 Full-Length Publications and Book Chapters 1. Nagy, Z.M., and Murphy, J.M. (1974). Development of a short-term memory capacity for escape

training in neonatal C3H mice. Bulletin of the Psychonomic Society 3: 19-20. 2. Nagy, Z.M., and Murphy, J.M. (1974). Learning and retention of a discriminated escape response in

infant mice. Developmental Psychobiology 7: 185-192. 3. Nagy, Z.M., Murphy, J.M., and Ray, D. (1975). Development of behavioral arousal and inhibition in

the Swiss-Webster mouse. Bulletin of the Psychonomic Society 6: 146-148. 4. Murphy, J.M., and Nagy, Z.M. (1976). Neonatal hyperthyroidism alters the development of

behavioral arousal and inhibition in the mouse. Bulletin of the Psychonomic Society 8: 121-123. 5. Murphy, J.M., and Nagy, Z.M. (1976). Development of cholinergic inhibitory capacities in the

hyperthyroid mouse. Pharmacology Biochemistry & Behavior 5: 449-456. 6. Murphy, J.M., and Nagy, Z.M. (1976). Neonatal thyroxine stimulation accelerates the maturation of

both locomotor and memory processes in mice. Journal of Comparative and Physiological Psychology 90: 1082-1091.

7. Nagy, Z.M., Murphy, J.M., and Ray, D. (1978). Relative aversion thresholds for shock in infant mice. Developmental Psychobiology 11: 261-270.

8. Murphy, J.M., Meeker, R.B., Porada, K.J., and Nagy, Z.M. (1979). GABA-mediated behavioral inhibition during ontogeny in the mouse. Psychopharmacology 64: 237-242.

9. Murphy, J.M., and Nagy, Z.M. (1979). Comparison of behavioral activity in two apparatus for food deprived mice. Bulletin of the Psychonomic Society 14: 43-45.

10. Murphy, J.M., and Nagy, Z.M. (1979). FLA-63 blocks food-deprivation induced behavioral arousal in the mouse. Physiological Psychology 7: 407-411.

11. Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1980). LCEC determination of monoamine levels in nine brain regions of alcohol-preferring rats. Symposium on the Neurochemical and Clinical Applications of LCEC 1: 63-64.

12. Gold, P.E., and Murphy, J.M. Brain noradrenergic responses to training and to amnestic frontal cortex stimulation. (1980). Pharmacology Biochemistry & Behavior 13: 257-263.

13. Forster, M.J., Nagy, Z.M., and Murphy, J.M. (1981). Potentiation of amphetamine-induced hyperactivity in the adult mouse following neonatal thyroxine administration. Bulletin of the Psychonomic Society 18: 337-339.

14. Murphy, J.M., Flint, R.S., Calkins, P.M., Ciancone, M.T., and McBride, W.J. (1982). Application of LCEC for the determination of the in vitro stimulated monoamine release from discrete regions of rat brain. Symposium on the Biomedical Applications of LCEC and Voltammetry 3: No. 62.

15. Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1982). Regional brain levels of monoamines in alcohol-preferring and -nonpreferring lines of rats. Pharmacology Biochemistry & Behavior 16: 145-149.

16. Gold, P.E., Murphy, J.M., and Cooley, S. (1982). Neuroendocrine modulation of memory during development. Behavioral and Neural Biology 35: 277-293.

17. McBride, W.J., Flint, R.S., Ciancone, M.T., and Murphy, J.M. (1983). In vitro release of endogenous monoamines and amino acids from several CNS regions of the rat. Neurochemical Research 8: 245-257.

18. Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1983). Monoamine and metabolite levels in CNS regions of the P line of alcohol-preferring rats after acute and chronic ethanol treatment. Pharmacology Biochemistry & Behavior 19: 849-856.

19. Flint, R.S., Murphy, J.M., and McBride, W.J. (1985). Release of endogenous dopamine, 3,4-dihydroxyphenylacetic acid and amino acid transmitters from rat striatal slices. Neurochemical Research 10: 515-527.

20. Murphy, J.M., Cunningham, S.D., and McBride, W.J. (1985). Effects of 250 mg% ethanol on monoamine and amino acid release from rat striatal slices. Brain Research Bulletin 14: 439-442.

21. Murphy, J.M., Waller, M.B., Gatto, G.J., McBride, W.J., Lumeng, L., and Li, T.-K. (1985). Monoamine uptake inhibitors attenuate ethanol intake in alcohol-preferring (P) rats. Alcohol 2: 349-352.

22. Flint, R.S., Murphy, J.M., Calkins, P.M., and McBride, W.J. (1985). Monoamine, amino acid and cholinergic interactions in slices of rat cerebral cortex. Brain Research Bulletin 15: 197-202.

James M. Murphy 13 23. McBride, W.J., Murphy, J.M., Lumeng, L., and Li, T.-K. (1986). Effects of ethanol on monoamine

and amino acid release from cerebral cortical slices of the alcohol-preferring P-line of rats. Alcoholism: Clinical and Experimental Research 10: 205-208.

24. Waller, M.B., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1986). Effect of low dose ethanol on spontaneous motor activity in alcohol-preferring and -nonpreferring rats. Pharmacology Biochemistry & Behavior 24: 617-623.

25. Li, T.-K., Lumeng, L., McBride, W.J., Waller, M.B., and Murphy, J.M. (1986). Studies on an animal model of alcoholism. In: Genetic and Biological Markers in Drug Abuse and Alcoholism, NIDA Research Monograph No. 66, edited by M.C. Braude & H.M. Chao. Washington, DC, U.S. Government Printing Office, 41-49.

26. Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1986). Alcohol preference and regional brain monoamine contents of N/Nih heterogeneous stock rats. Alcohol and Drug Research 7: 33-37.

27. Murphy, J.M., Gatto, G.J., Waller, M.B., McBride, W.J., Lumeng, L., and Li, T.-K. (1986). Effects of scheduled access on ethanol intake by the alcohol-preferring (P) line of rats. Alcohol 3: 331-336.

28. Li, T.-K., Lumeng, L., McBride, W.J., and Murphy, J.M. (1987). Rodent lines selected for factors affecting alcohol consumption. Alcohol & Alcoholism Suppl. 1: 91-96.

29. Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1987). Contents of monoamines in forebrain regions of alcohol-preferring (P) and -nonpreferring (NP) lines of rats. Pharmacology Biochemistry & Behavior 26: 389-392.

30. Gatto, G.J., Murphy, J.M., Waller, M.B., McBride, W.J., Lumeng, L., and Li, T.-K. (1987). Chronic ethanol tolerance through free-choice drinking in the P line of alcohol-preferring rats. Pharmacology Biochemistry & Behavior 28: 111-115.

31. Gatto, G.J., Murphy, J.M., Waller, M.B., McBride, W.J., Lumeng, L., and Li, T.-K. (1987). Persistence of tolerance to a single dose of ethanol in the selectively bred alcohol-preferring P rat. Pharmacology Biochemistry & Behavior 28: 105-110.

32. Li, T-K., Lumeng, L., McBride, W.J., and Murphy, J.M. (1987). Alcoholism: Is it a model for the study of disorders of mood and consummatory behavior? Annals of the New York Academy of Sciences 499: 239-249.

33. Lumeng, L., Murphy, J.M., McBride, W.J., and Li, T-K. (1987). Basic neurochemical mechanisms of modulation of alcohol consumption in the P and NP rats. In: Pharmacology: Proceedings of the Xth International Congress of Pharmacology, edited by M.J. Rand and C. Raper. New York: Elsevier, 727-730.

34. Khatib, S.A., Murphy, J.M., and McBride, W.J. (1988). Biochemical evidence for activation of specific monoamine pathways by ethanol. Alcohol 5: 295-299.

35. Li, T.-K., Lumeng, L., Doolittle, D.P., McBride, W.J., Murphy, J.M., Froehlich, J.C., and Morzorati, S. (1988). Behavioral and neurochemical associations of alcohol-seeking behavior. In: Biomedical and Social Aspects of Alcohol and Alcoholism, edited by K. Kuriyama, A. Takada, and H. Ishii. Amsterdam: Excerpta Medica, 435-438.

36. Li, T.-K., Lumeng, L., Froehlich, J.C., Murphy, J.M., and McBride, W.J. (1988). Genetic influence on response to the reinforcing properties of ethanol in rats. In: Biomedical and Social Aspects of Alcohol and Alcoholism, edited by K. Kuriyama, A. Takada, and H. Ishii. Amsterdam: Excerpta Medica, 487-490.

37. Li, T.-K., Lumeng, L., McBride, W.J., Murphy, J.M., Froehlich, J.C., and Morzorati, S. (1988). Pharmacology of alcohol preference in rodents. Advances in Alcohol & Substance Abuse 7: 73-86.

38. Lumeng, L., Murphy, J.M., McBride, W.J., and Li, T.-K. (1988). Behavioral and biochemical correlates of alcohol drinking preference: Studies on the selectively bred P and NP rats. Australian Alcohol and Drug Review 7: 17-20.

39. McBride, W.J., Murphy, J.M., Lumeng, L., and Li, T.-K. (1988). Effects of Ro 15-4513, fluoxetine and desipramine on the intake of ethanol, water and food by the alcohol-preferring (P) and -nonpreferring (NP) lines of rats. Pharmacology Biochemistry and Behavior 30: 1045-1050.

40. Murphy, J.M., McBride, W.J., Gatto, G.J., Lumeng, L., and Li, T.-K. (1988). Effects of acute ethanol administration on monoamine and metabolite content in forebrain regions of ethanol- tolerant and -nontolerant alcohol-preferring (P) rats. Pharmacol Biochem Behav 29: 169-174.

41. Murphy, J.M., Waller, M.B., Gatto, G.J., McBride, W.J., Lumeng, L., and Li, T.-K. (1988). Effects of fluoxetine on the intragastric self-administration of ethanol in the alcohol preferring P line of rats. Alcohol 5: 283-286.

James M. Murphy 14 42. McBride, W.J., Murphy, J.M., Lumeng, L., and Li, T.-K. (1989). Serotonin and ethanol preference. In:

Recent Developments in Alcoholism, Vol. 7, edited by M. Galanter. New York: Plenum, 187-209. 43. Gongwer, M.A., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1989). Regional brain

contents of serotonin, dopamine and their metabolites in the selectively bred high- and low-alcohol drinking lines of rats. Alcohol 6: 317-320, 1989.

44. Lumeng, L., Li, T.-K., McBride, W.J., Murphy, J.M., Morzorati, S., and Froehlich, J.C. (1989). Mechanism(s) of modulation of alcohol consumption: Studies on the P and NP rats. In: Molecular Mechanisms of Alcohol, edited by G.Y. Sun, Y.-H. Wei, P.K. Rudeen, W.G. Wood and A.Y. Sun. Clifton, NJ: Humana Press, 359-370.

45. McBride, W.J., Murphy, J.M., Lumeng, L., and Li, T.-K. (1989). Spiroxatrine augments the fluoxetine induced reduction of ethanol intake by alcohol-preferring (P) rats. Pharmacology Biochemistry and Behavior 34: 381-386.

46. Murphy, J.M., Gatto, G.J., McBride, W.J., Lumeng, L., and Li, T.-K. (1989). Operant responding for oral ethanol in the alcohol-preferring P and alcohol-nonpreferring NP lines of rats. Alcohol 6: 127-131.

47. Wong, D.T., and Murphy, J.M. (1989). Serotonergic mechanisms in alcohol intake. In: Molecular Mechanisms of Alcohol, edited by G.Y. Sun, Y.-H. Wei, P.K. Rudeen, W.G. Wood and A.Y. Sun. Clifton, NJ: Humana Press, 133-146.

48. Gatto, G.J., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1990). Effects of fluoxetine and desipramine on palatability-induced ethanol consumption in the alcohol-nonpreferring (NP) line of rats. Alcohol 7: 531-536.

49. McBride, W.J., Murphy, J.M., Lumeng, L., and Li, T.-K. (1990). Serotonin, dopamine and GABA involvement in alcohol drinking of selectively bred rats. Alcohol 7: 199-205. (Selected for Reprinting in: Annual Review of Addictions Research and Treatment, 1992, 193-202.)

50. Murphy, J.M., Gatto, G.J., McBride, W.J., Lumeng, L., and Li, T.-K. (1990). Persistence of tolerance in the P line of alcohol-preferring rats does not require performance while intoxicated. Alcohol 7: 367-369.

51. Engleman, E.A., Hingtgen, J.N., Zhou, F.C., Murphy, J.M., and Aprison, M.H. (1991). Potentiated 5-hydroxytryptophan response suppression following 5,7-dihydroxytyptamine raphe lesions in an animal model of depression. Biological Psychiatry, 30: 317-320.

52. Levy, A.D., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1991). Microinjection of sulpiride into the nucleus accumbens increases ethanol intake of alcohol-preferring (P) rats. Alcohol & Alcoholism (Suppl. 1): 417-420.

53. McBride, W.J., Murphy, J.M., Gatto, G.J., Levy, A.D., Lumeng, L., and Li, T.-K. (1991). Serotonin and dopamine systems regulating alcohol intake. Alcohol & Alcoholism (Suppl. 1): 411-416.

54. Stewart, R.B., McBride, W.J., Lumeng, L., Li, T.-K., and Murphy, J. M. (1991). Chronic Alcohol Consumption in alcohol-preferring P rats attenuates subsequent conditioned taste aversion produced by ethanol injections. Psychopharmacology, 105: 530-534.

55. Zhou, F.C., Bledsoe, S., and Murphy, J. (1991). Serotonergic sprouting is induced by dopamine-lesion in substantia nigra of adult rat brain. Brain Research, 556:108-116.

56. Engleman, E.A., Murphy, J.M., Zhou, F.C., and Hingtgen, J.N. (1992). Response suppression induced with selective 5-HT agonists can be differentially blocked with LY53857 in an animal model of depression. Neurochemical Research, 17: 483-488.

57. Engleman, E.A., Hingtgen, J.N., Zhou, F.C., Murphy, J.M., and Aprison, M.H. (1992). Evidence of hypersensitive postsynaptic serotonin receptors in an animal model of depression. In R. Murison (ed.), Endocrine and Nutritional Control of Basic Biological Function. Toronto: Holgrefe-Huber, 421-425.

58. McBride, W.J., Murphy, J.M., Lumeng, L., and Li, T.-K. (1992). Serotonin and alcohol consumption. In: C.A. Naranjo and E.M. Sellers (eds.), Novel Pharmacological Interventions for Alcoholism. New York: Springer-Verlag, pp. 59-67.

59. Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1992). Serotonin and ethanol drinking in the alcohol-preferring (P) rat. Clinical Neuropharmacology, 15 (Suppl. 1A): 301-302.

60. Dyr, W., McBride, W.J., Lumeng, L., Li, T.-K. and Murphy J.M. (1993). Effects of D1 and D2 dopamine receptor agents on ethanol consumption in the high alcohol drinking (HAD) line of rats. Alcohol, 10: 207-212.

James M. Murphy 15 61. Li, T.-K., Lumeng, L., McBride, W.J., and Murphy, J.M. (1993). An experimental approach to

understanding the genetic and neurobiological basis of alcoholism. Transactions of the American Clinical and Climatological Association. 104: 61-73.

62. McBride, W.J., Murphy, J.M., Gatto, G.J., Levy, A.D., Yoshimoto, K., Lumeng, L., and Li, T.-K. (1993). CNS mechanisms of alcohol self-administration. Alcohol & Alcoholism (Suppl. 2): 463-467.

63. McBride, W.J., Murphy, J.M., Yoshimoto, K., Lumeng, L., and Li, T.-K. (1993). Serotonin mechanisms in alcohol drinking behavior. Drug Development Research, 30: 170-177.

64. McBride, W.J., Murphy, J.M., Lumeng, L., and Li, T.-K. (1993). Serotonin regulation of alcohol drinking. In: P.M. Vanhoutte, P.R. Saxena, R. Paoletti, N. Brunello and A.S. Jackson (eds.), Second International Symposium on Serotonin from Cell Biology to Pharmacology and Therapeutics. Milan, Italy: Kluwer Academic Publishers, 375-381.

65. Stewart, R.B., Gatto, G.J., Lumeng, L., Li, T.-K., and Murphy, J.M. (1993). Comparison of alcohol-preferring P and -nonpreferring NP rats on tests of anxiety and on the anxiolytic effects of ethanol. Alcohol, 10: 1-10.

66. Gatto, G.J., McBride, W.J., Murphy, J.M., Lumeng, L., and Li, T.-K. (1994). Ethanol self-infusion into the ventral tegmental area by alcohol-preferring rats. Alcohol 11: 557-564.

67. June, H.L., Murphy, J.M., Mellor-Burke, J.J. Lumeng, L., and Li, T.-K. (1994). The benzodiazepine inverse agonist Ro19-4603 exerts prolonged and selective suppression of ethanol intake in alcohol-preferring (P) rats. Psychopharmacology, 115: 325-331.

68. Li, T.-K., Lumeng, L., McBride, W.J. and Murphy, J.M. Genetic and neurobiological basis of alcohol-seeking behavior. Alcohol Alcohol. 29:697-700, 1994.

69. Stewart, R.B., Russell, R.N., Lumeng, L., Li, T.-K., and Murphy, J.M. (1994). Consumption of sweet, salty, sour and bitter solutions by selectively-bred alcohol preferring P and nonpreferring NP lines of rats. Alcoholism: Clinical and Experimental Research, 18: 375-381.

70. Zhou, F.C., Pu, C.F., Murphy, J., Lumeng, L., and Li, T.-K. (1994). Serotonergic Neurons in the alcohol preferring rats. Alcohol 11: 397-403.

71. Engleman, E.A., Murphy, J.M. Zhou, F.C., Aprison, M.H., and Hingtgen, J.N. (1995) Operant response suppression induced with systemic administraton of 5-hydroxytryptophan is centrally mediated. Pharmacology Biochemistry and Behavior 52: 525-529.

72. June, H.L., Lin, M., Greene, T.L., Lewis, M.J., and Murphy, J.M. (1995). Effects of negative modulators of GABAergic efficacy on ethanol intake: Correlation of biochemical changes with pharmacological effect using a behavioral paradigm. Experimental and Clinical Psychopharmacology 3: 252-260.

73. June, H.L., Duemler, S.E., Greene, T.L., Williams, J.A., Lin, M., Devaraju, S.L., Chen, S.H.A., Lewis, M.J., and Murphy, J.M. (1995). Effects of the benzodiazepine inverse agonist RO19-4603 on the maintenance of tolerance to a single dose of ethanol. Journal of Pharmacology and Experimental Therapeutics 274: 1105-1112.

74. June, H.L., Murphy, J.M., Hewitt, R.L., Greene, T.L., Lin, M., Mellor-Burke, J.J., Lumeng, L., and Li, T.-K. (1996). Benzodiazepine receptor ligands with different intrinsic efficacies alter ethanol intake in alcohol-nonpreferring (NP) rats. Neuropsychopharmacology 14: 55-66.

75. Lumeng, L., Li, T.-K., Murphy, J.M., and McBride, W.J. (1995). Genetic influences on alcohol preference in animals. In: H. Begleiter and B. Kissin (eds.), Genetics of Alcoholism, Vol 1. New York: Oxford University Press, pp. 165-201.

76. Stewart, R.B., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1996). Place conditioning with alcohol in alcohol-preferring P and -nonpreferring NP rats. Pharmacology Biochemistry and Behavior 53: 487-491.

77. McKinzie, D.L., Eha, R., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1996). Effects of taste aversion training on the acquisition of alcohol drinking in adolescent P and HAD rat lines. Alcoholism: Clinical and Experimental Research 20: 682-687.

78. Katner, S.N., McBride, W.J., Lumeng, L., Li, T.-K., and Murphy, J.M. (1996). Effects of cholinergic agents on locomotor activity of P and NP rats. Alcoholism: Clinical and Experimental Research 20: 1004-1010.

79. Russell, R.N., McBride, W.J., Lumeng, L., Li, T.-K., and Murphy, J.M. (1996). Apomorphine and 7-OH DPAT reduce ethanol intake of P and HAD rats. Alcohol 13: 515-519.

James M. Murphy 16 80. June, H.L., Greene, T.L., Murphy, J.M., Hite, M., Williams, J.A, Cason, C.R., Mellor-Burke, J.J., Cox,

R., Duemler, S.E., Torres, L., Lumeng, L., and Li, T.-K. (1996). Effects of the benzodiazepine inverse agonist RO19-4603 alone, and in combination with the benzodiazepine receptor antagonists, flumazenil, ZK 93426, and CGS 8216 on ethanol intake in alcohol-preferring (P) rats. Brain Research 734: 19-34.

81. Ikemoto, S., Murphy, J.M., and McBride, W.J. (1997). Self-infusion of GABAA antagonists directly into the ventral tegmental area and adjacent regions. Behavioral Neuroscience 111: 369-380.

82. Katner, S.N., McBride, W.J., Lumeng, L., Li, T.-K., and Murphy, J.M. (1997). Involvement of the cholinergic system in alcohol drinking behavior. Addiction Biology 2: 215-223.

83. Katner, S.N., McBride, W.J., Lumeng, L., Li, T.-K., and Murphy, J.M. (1997). Alcohol intake of P rats is regulated by muscarinic receptors in the pedunculopontine nucleus and VTA. Pharmacology Biochemistry and Behavior 54: 497-504.

84. Godfrey, C.D., Stewart, R.B., Froehlich, J.C., Li, T.-K., and Murphy, J.M. (1997). Comparison of rats selectively bred for high and low ethanol intake in a forced swim test model of depression: Effects of desipamine. Physiology & Behavior 62: 729-733.

85. Ikemoto, S., McBride, W.J., Murphy, J.M., Lumeng, L., and Li, T.-K. (1997). 6-OHDA-lesions of the nucleus accumbens disrupt the acquisition but not the maintenance of ethanol consumption in the alcohol-preferring P line of rats. Alcoholism: Clinical and Experimental Research 21: 1042-1046.

86. Ikemoto, S., Glazier, B.S., Murphy, J.M., and McBride, W.J. (1997). Role of dopamine D1 and D2 receptors of the nucleus accumbens in mediating reward. Journal of Neuroscience 17: 8580-8587.

87. June, H.L., Zucarelli, D., Torres, L., Craig, K.S., DeLong, J., Allen, A. Braun, M.R., Cason, C.R., and Murphy, J.M. (1998). High affinity benzodiazepine antagonists reduce ethanol-reinforced responding maintained by ethanol presentation in ethanol-preferring rats. Journal of Pharmacology and Experimental Therapeutics 284: 1006-1914.

88. June, H.L., Torres, L., Cason, C.R., Hwang, B.H., Braun, M.R., and Murphy, J.M. (1998). The novel benzodiazepine inverse agonist RO19-4603 antagonizes ethanol motivated behaviors: Neuropharmacological studies. Brain Research 784:256-275.

89. June, H.L., Dejaravu, S.L., Eggers, M.W., Williams, J.A., Cason, C.R., Greene, T.L., Leviege, T., Braun, M.R., Torres, L., and Murphy, J.M. (1998). Benzodiazepine receptor antagonists modulate the actions of ethanol in alcohol-preferring and -nonpreferring rats. European Journal of Pharmacology, 342: 139-151.

90. Ikemoto, S., Glazier, B.S., Murphy, J.M., and McBride, W.J. (1998). Rats self-administer carbachol directly into the nucleus accumbens. Physiology & Behavior, 63: 811-814.

91. Ikemoto, S., Murphy, J.M., and McBride, W.J. (1998). Regional differences within the rat ventral tegmental area for muscimol self-infusions. Pharmacology Biochemistry and Behavior 61:87-92.

92. McKinzie, D.L., Eha, R., Cox, R. Stewart, R.B., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1998). Serotonin3 receptor antagonism of alcohol intake: Effects of drinking conditions. Alcohol 15:291-298.

93. McKinzie, D.L., Nowak, K.L., Yorger, L., McBride, W.J., Murphy, J.M., Lumeng, L., and Li, T.-K. (1998) The alcohol deprivation effect in the alcohol-preferring P rat under free-drinking and operant access conditions. Alcoholism: Clinical and Experimental Research 22: 1170-1176.

94. McKinzie, D.L., Nowak, K. L., Murphy, J.M., Li, T.-K., Lumeng, L., and McBride, W.J. (1998) Development of alcohol drinking in rat lines selectively bred for divergent alcohol preference. Alcoholism: Clinical and Experimental Research 22: 1584-1590.

95. Nowak, K.L., McBride, W.J., Lumeng, L., Li, T.-K., and Murphy, J.M. (1998) Blocking GABAA receptors in the anterior ventral tegmental area attenuates ethanol intake of the alcohol-preferring P rat. Psychopharmacology 139: 108-116.

96. McKinzie, D.L., McBride, W.J., Murphy, J.M., Lumeng, L., and Li, T.-K. (1999). Rat lines selectively bred for alcohol preference: A potential animal model for adolescent alcohol drinking. In: J.H. Hannigan, L.P. Spear, N.E. Spear, and C. Goodlett (Eds.), Alcohol and Alcoholism: Effects on Brain and Development. Lawrence Erlbaum Associates, Erlbaum. Mahwah, NJ, pp. 135-160.

97. McKinzie, D.L., Rodd, Z.A., Dagon, C.L., Murphy, J.M., and McBride, W.J. (1999). Cocaine is self-administered into the shell region of the nucleus accumbens in Wistar rats. Annals of the New York Academy of Sciences 877: 788-791.

98. McBride, W.J., Murphy, J.M., and Ikemoto, S. (1999) Localization of brain reinforcement mechanisms: Intracranial self-administration and intracranial place conditioning studies. Behavioural Brain Research 101: 129-152.

James M. Murphy 17 99. Nowak, K.L., McKinzie, D.L., McBride, W.J., and Murphy, J.M. (1999). Patterns of ethanol and

saccharin intake in P rats under limited-access conditions. Alcohol 19: 85-96. 100. McKinzie, D.L., Cox, R., Murphy, J.M., Li, T.-K. Lumeng, L., and McBride, W.J. (1999). Voluntary

ethanol drinking during the first three postnatal weeks in lines of rats selectively bred for divergent ethanol preference. Alcoholism: Clinical and Experimental Research 23: 1892-1897.

101. Rodd-Henricks, Z.A., McKinzie, D.L., Shaikh, S.R., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (2000). The alcohol deprivation effect is prolonged in the alcohol preferring (P) rat after repeated deprivations. Alcoholism: Clinical and Experimental Research 24: 8-16.

102. McKinzie, D.L., Sajdyk, T.J., McBride, W.J., Murphy, J.M., Lumeng, L., Li, T.-K., and Shekhar, A. (2000). Acoustic startle and fear-potentiated startle responding in alcohol-preferring (P) and -nonpreferring (NP) lines of rats. Pharmacology Biochemistry and Behavior 65:691-696.

103. Nowak, K.L., McBride, W.J., Lumeng, L., Li, T.-K., and Murphy, J.M. (2000) Involvement of dopamine D2 autoreceptors in the ventral tegmental area on alcohol and saccharin intake of the alcohol preferring P rat. Alcoholism: Clinical and Experimental Research 24: 476-483.

104. Nowak, K.L., Ingraham, C.M., McKinzie, D.L., McBride, W.J., Lumeng, L., Li, T.-K., and Murphy, J.M. (2000) An assessment of novelty-seeking behavior in alcohol-preferring and non-preferring rats. Pharmacology Biochemistry and Behavior 66: 113-121.

105. Rodd-Henricks, Z.A., McKinzie, D.L., Crile, R.S., Murphy, J.M., and McBride, W.J. (2000) Regional heterogeneity for the intracranial self-administration of ethanol within the ventral tegmental area of Wistar rats. Psychopharmacology 149: 217-224

106. Engleman, E.A., McBride, W.J., Wilber, A.A., Shaikh, S.R., Eha, R.D., Lumeng, L., Li, T.-K., and Murphy, J.M. (2000) Reverse microdialysis of a dopamine uptake inhibitor in the nucleus accumbens of alcohol-preferring rats: Effects on dialysate dopamine levels and ethanol intake. Alcoholism: Clinical and Experimental Research 24: 795-801

107. Rodd-Henricks, Z.A., McKinzie, D.L., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (2000) The expression of an alcohol deprivation effect in the high-alcohol-drinking replicate rat lines is dependent upon repeated deprivations. Alcoholism: Clinical and Experimental Research 24: 747-753

108. Rodd-Henricks, Z.A., McKinzie, D.L., Edmundson, V.E., Dagon, C.L., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (2000) Effects of 5-HT3 receptor antagonists on daily alcohol intake under acquisition, maintenance, and relapse conditions in alcohol-preferring (P) rats. Alcohol 21: 73-85

109. McKinzie, D.L., McBride, W.J., Murphy, J.M., Lumeng, L., and Li, T.-K. (2000) Effects of MDL72222, a serotonin3 antagonist, on operant responding for ethanol by alcohol-preferring P rats. Alcoholism: Clinical and Experimental Research 24: 1500-1504.

110. Jones, A.E., McBride, W.J., Murphy, J.M., Lumeng, L., Li, T.-K., Shekhar, A., and McKinzie, D.L. (2000) Effects of ethanol on startle responding in alcohol-preferring (P) and -nonpreferring (NP) rats. Pharmacology Biochemistry and Behavior 67: 313-318.

111. Bell, R.L., McKinzie, D.L., Murphy, J.M., and McBride, W.J. (2000) Sensitivity and tolerance to the motor impairing effects of moderate doses of ethanol. Pharmacology Biochemistry and Behavior 67: 583-586.

112. Badia-Elder, N.E., Stewart, R.B., Powrozek, T.A., Roy, K.F., Murphy, J.M., and Li, T.-K. (2001) Effect of neuropeptide Y (NPY) on oral ethanol intake in Wistar, alcohol preferring (P), and -nonpreferring (NP) rats. Alcoholism: Clinical and Experimental Research 25: 386-390

113. Bell, R.L., Stewart, R. B., Woods, J.E., II, Lumeng, L., Li, T.-K., Murphy, J.M., and McBride, W.J (2001) Responsivity and development of tolerance to the motor impairing effects of moderate doses of ethanol in alcohol-preferring (P) and -nonpreferring (NP) rat lines. Alcoholism: Clinical and Experimental Research 25: 644-650

114. Smith, D.G., Learn, J.E., McBride, W.J., Lumeng, L., Li, T.-K., and Murphy, J.M. (2001) Long-term effects of alcohol drinking on cerebral glucose utilization in alcohol-preferring P rats. Pharmacology Biochemistry and Behavior 69: 543-553.

115. Rodd-Henricks, Z.A., Bell, R.L., Kuc, K.A., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (2001) Effects of concurrent access to multiple ethanol concentrations and repeated deprivations on alcohol intake of alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental Research 25: 1140-1150.

116. Smith, D.G., Learn, J.E., McBride, W.J., Lumeng, L., Li, T.-K., and Murphy, J.M. (2001) Alcohol-naive alcohol-preferring (P) rats exhibit higher local cerebral glucose utilization than alcohol non-preferring (NP) and Wistar rats. Alcoholism: Clinical and Experimental Research 25: 1309-1316.

James M. Murphy 18 117. McKinzie DL, McBride WJ, Murphy JM, Lumeng L, Li T-K. (2002) Effects of amphetamine on

locomotor activity in adult and periadolescent alcohol-preferring P and -nonpreferring NP rats. Pharmacology Biochemistry and Behavior 71: 29-36.

118. Melendez RI, Rodd-Henricks ZA, Engleman EA, Li T-K, McBride WJ, Murphy JM. (2002) Microdialysis of dopamine in the nucleus accumbens of alcohol preferring (P) rats during anticipation and operant self-administration of ethanol. Alcoholism: Clinical and Experimental Research 26: 318-325.

119. Smith DG, Learn JE, McBride WJ, Lumeng L, Li T-K, Murphy JM. (2002) Cerebral glucose utilization after relapse in ethanol drinking in alcohol-preferring P rats. Alcohol 27:115-126.

120. Bell RL, Rodd-Henricks ZA, Webster AA, Lumeng L, Li T-K, McBride WJ, Murphy JM. (2002) Heart rate and motor activiating effects of orally self-administered ethanol in alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental Research 26: 1162-1170.

121. Murphy JM, Stewart RB, Bell RL, Badia-Elder N E, Carr LG, McBride WJ, Lumeng L, Li T-K. (2002) Phenotypic and genotypic characterization of the Indiana University rat lines selectively bred for high and low alcohol preference. Behavior Genetics 32: 363-388.

122. Rodd-Henricks ZA, McKinzie DL, Li T-K, Murphy JM, McBride WJ. (2002) Cocaine is self-administered into the shell but not the core of the nucleus accumbens of Wistar rats. Journal of Pharmacology and Experimental Therapeutics 303: 1216-1226.

123. Rodd-Henricks ZA, Bell RL, Kuc KA, Murphy JM, McBride WJ, Lumeng L, Li T-K. (2002) Effects of ethanol exposure on subsequent acquisition and extinction of ethanol self-administration and expression of alcohol-seeking behavior in adult alcohol-preferring (P) rats. I. Periadolescent exposure. Alcoholism: Clinical and Experimental Research 26: 1632-1641.

124. Rodd-Henricks ZA, Bell RL, Kuc KA, Murphy JM, McBride WJ, Lumeng L, Li T-K. (2002) Effects of ethanol exposure on subsequent acquisition and extinction of ethanol self-administration and expression of alcohol-seeking behavior in adult alcohol-preferring (P) rats. II. Adult exposure. Alcoholism: Clinical and Experimental Research 26: 1642-1652.

125. Rodd-Henricks ZA, McKinzie DL, Melendez RI, Berry N, Murphy JM, McBride WJ. (2003) Effects of serotonin-3 receptor antagonists on the intracranial self-administration of ethanol within the ventral tegmental area of Wistar rats. Psychopharmacology 165: 252-259.

126. Engleman EA, McBride WJ, Lumeng L, Li T-K, Murphy JM. (2003) Ethanol drinking experience attenuates (-) sulpiride-induced increases in extracellular dopamine levels in the nucleus accumbens of alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental Research 27: 424-431.

127. Melendez RI, Rodd-Henricks ZA, McBride WJ, Murphy JM. (2003) Alcohol stimulates the release of dopamine in the ventral pallidum but not in the globus pallidus: A dual-probe microdialysis study. Neuropsychopharmacology 28: 939-946.

128. Gilpin NW, Stewart RB, Murphy JM, Li T-K, Badia-Elder NE. (2003) Neuropeptide Y reduces oral ethanol intake in alcohol-preferring (P) rats following a period of imposed ethanol abstinence. Alcoholism: Clinical and Experimental Research 27: 787-794.

129. Bell RL, Rodd ZA, Hsu CC, Lumeng L, Murphy JM McBride, WJ. (2003). Amphetamine-modified acoustic startle responding and prepulse inhibition in adult and adolescent P and NP rats. Pharmacology Biochemistry and Behavior, 75: 163-171.

130. Bell RL, Rodd-Henricks ZA, Kuc KA, Lumeng L, Li T-K, Murphy JM, McBride WJ. (2003) Effects of concurrent access to single concentration or multiple concentrations of ethanol on the intake of ethanol by male and female periadolescent alcohol-preferring (P) rats. Alcohol 29: 137-148.

131. Rodd ZA, Bell RL, Kuc KA, Murphy JM, Lumeng L, Li T-K, McBride WJ. (2003) Effects of repeated alcohol deprivations on operant ethanol self-administration by alcohol-preferring (P) rats. Neuropsychopharmacology 28: 1614-1621.

132. Badia-Elder NE, Stewart RB, Powrozek TA, Murphy JM, Li T-K. (2003) Effects of neuropeptide Y (NPY) on sucrose and ethanol intake and on anxiety-like behavior in high alcohol drinking (HAD) and low alcohol drinking (LAD) rats. Alcoholism: Clinical and Experimental Research 27: 894-899

133. Rodd ZA, Melendez R, Bell RL, Kuc K, Zhang Y, Murphy JM, McBride WJ. (2004) Intracranial self-administration of ethanol within the ventral tegmental area of male Wistar rats: Evidence for involvement of dopamine neurons. Journal of Neuroscience 24: 1050-1057.

134. Thielen RJ, Engleman EA, Rodd ZA, Murphy JM, Lumeng L, Li T-K, McBride WJ. (2004) Ethanol drinking and deprivation alter dopaminergic and serotonergic function in the nucleus accumbens of alcohol-preferring rats. Journal of Pharmacology and Experimental Therapeutics 309: 216-225.

James M. Murphy 19 135. McBride WJ, Lovinger DM, Machu T, Thielen RJ, Rodd ZA, Murphy JM, Roache JD, Johnson BA.

(2004) Serotonin-3 Receptors in the Actions of Alcohol, Alcohol Reinforcement and Alcoholism. Alcoholism: Clinical and Experimental Research 28: 257-267.

136. Rodd ZA, Bell RL, McKinzie DL, Webster AA, Murphy JM, Lumeng L, Li T-K, McBride WJ. (2004) Low-dose stimulatory effects of ethanol during adolescence in rat lines selectively bred for high alcohol intake. Alcoholism: Clinical and Experimental Research 28: 535-543.

137. Melendez RI, Rodd ZA, McBride WJ, Murphy JM. (2004) Involvement of the mesopallidal dopamine system in ethanol reinforcement. Alcohol 32: 137-144.

138. Gilpin NW, Stewart RB, Elder RL, Kho Y, Murphy JM, Li T-K, Badia-Elder NE. (2004) Sedative and motor-impairing effects of neuropeptide Y in selectively bred P and NP rats. Pharmacology Biochemistry and Behavior 78: 65-73.

139. Rodd ZA, Bell RL, Melendez RI, Kuc KA, Lumeng L, Li T-K, Murphy JM, McBride WJ. (2004) Comparison of intracranial self-administration of ethanol within the posterior ventral tegmental area between alcohol-preferring (P) and Wistar rats. Alcoholism: Clinical and Experimental Research 28: 1212-1219.

140. Engleman EA, Ingraham CM, O’Brien CE, McBride WJ, Murphy JM. (2004) Effect of housing conditions on sulpiride-induced increases in extracellular dopamine (DA) levels in the nucleus accumbens of alcohol-preferring (P) rats. Brain Research 1022: 247-250.

141. Gilpin NW, Stewart RB, Murphy JM, Badia-Elder NE. (2004) Neuropeptide Y (NPY) in the paraventricular nucleus of the hypothalamus increases ethanol intake in high- and low-alcohol-drinking rats. Alcoholism: Clinical and Experimental Research 28: 1492-1498.

142. Bell RL, Rodd ZA, Hsu CC, Lumeng L, Li T-K, Murphy JM, McBride WJ. (2004) Effects of concurrent access to ethanol to a single concentration or multiple concentrations of ethanol on alcohol intake by periadolescent high-alcohol-drinking rats. Alcohol 33: 107-115.

143. Rodd ZA, Bell RL, Sable HJK, Murphy JM, McBride WJ. (2004) Recent advances in animal models of alcohol craving and relapse. Pharmacology Biochemistry and Behavior 79: 439-450.

144. Bell RL, Rodd ZA, Boutwell CL, Hsu CC, Lumeng L, Murphy JM, Li T-K, McBride WJ. (2004) Effects of long-term episodic access to ethanol on the expression of an alcohol deprivation effect in low alcohol-consuming rats. Alcoholism: Clinical and Experimental Research 28: 1867-1874.

145. Bell RL, Rodd ZA, Murphy JM, McBride WJ. (2005). Use of selectively bred alcohol-preferring rats to study alcohol abuse, relapse and craving. In: Comprehensive Handbook of Alcohol Related Pathology, pp. 1517-1535, V.R. Preedy and R.R. Watson (Eds), Academic Press, Elsevier Science: New York.

146. Rodd ZA, Bell RL, Zhang Y, Murphy JM, Goldstein A, Zaffaroni A, Li T-K, McBride WJ. (2005) Regional heterogeneity for the intracranial self-administration of ethanol and acetaldehyde within the ventral tegmental area of alcohol-preferring (P) rats: Involvement of dopamine and serotonin. Neuropsychopharmacology 30: 330-338.

147. Melendez RI, Rodd ZA, McBride WJ, Murphy JM. (2005) Dopamine receptor regulation of ethanol intake and extracellular dopamine in the ventral pallidum of alcohol preferring (P) rats. Drug and Alcohol Dependence 77: 293-301.

148. Rodd ZA, Bell, RL McQueen VK, Davids MR, Hsu CC, Murphy JM, Li T-K, Lumeng L, McBride WJ. (2005) Chronic ethanol drinking by alcohol-preferring rats increases the sensitivity of the posterior ventral tegmental area to the reinforcing effects of ethanol. Alcoholism: Clinical and Experimental Research 29: 358-366.

149. McBride WJ, Bell RL, Rodd ZA, Strother WN, Murphy JM. (2005) Adolescent alcohol drinking and its long-range consequences: Studies with animal models. In Recent Developments in Alcoholism, Vol. 17 Alcohol Problems in Adolescents and Young Adults (M. Galanter, ed) Kluwer Academic/Plenum Publishers, New York.

150. Rodd ZA, Bell RL, Kuc KA, Zhang Y, Murphy JM, McBride WJ (2005) Intracranial self-administration of cocaine within the posterior ventral tegmental area of Wistar rats: Evidence for involvement of serotonin-3 receptors and dopamine neurons. Journal of Pharmacology and Experimental Therapeutics 313: 134-145, 2005.

151. Gilpin NW, Stewart RB, Murphy JM, Badia-Elder NE. (2005) Sensitized effects of neuropeptide Y on multiple ingestive behaviors in P rats following ethanol abstinence. Pharmacol Biochemistry and Behavior 81: 740-749.

James M. Murphy 20 152. Rodd ZA, Bell RL, McQueen VK, Davids MR, Hsu CC, Murphy JM, Li TK, Lumeng L, McBride WJ.

(2005) Prolonged increase in the sensitivity of the posterior ventral tegmental area to the reinforcing effects of ethanol following repeated exposure to cycles of ethanol access and deprivation. Journal of Pharmacology and Experimental Therapeutics. 315: 648-57.

153. Bell RL, Rodd, ZA, Sable HJK, Schultz JA, Hsu CC, Lumeng L, Murphy JM, McBride WJ (2006) Daily patterns of ethanol drinking in peri-adolescent and adult alcohol-preferring (P) rats. Pharmacology Biochemistry and Behavior, 83: 35-46.

154. Engleman EA, Ingraham CM, McBride WJ, Lumeng L, Murphy JM (2006) Extracellular dopamine levels are lower in the medial prefrontal cortex of alcohol-preferring (p) rats than wistar rats. Alcohol, 38: 5-12.

155. Rodd ZA, McKinzie DL, Bell RL, McQueen VK, Murphy JM, Schoepp DD, McBride WJ. (2006) The metabotropic glutamate 2/3 receptor agonist LY404039 reduces alcohol-seeking but not alcohol self-administration in alcohol-preferring (P) rats. Behavioural Brain Research 171: 207-215.

156. Oster SM, Toalston JE, Kuc KA, Pommer TJ, Murphy JM, Lumeng L, Bell RL, McBride WJ, Rodd ZA. (2006) Effects of multiple alcohol deprivations on operant ethanol self-administration by high-alcohol-drinking replicate rat lines. Alcohol 38: 155-164

157. Bell RL, Rodd, ZA, Lumeng L, Murphy JM, McBride WJ (2006) The alcohol-preferring P rat and animal models of excessive alcohol drinking. Addiction Biology, 11: 270-288.

158. Carroll MR, Rodd, ZA, Murphy JM and Simon JR (2006) Chronic ethanol consumption increases dopamine uptake in the nucleus accumbens of high alcohol drinking rats. Alcohol 40: 103-109.

159. Bell RL, Rodd, ZA,Schultz JA, Peper Cl, Lumeng L, Murphy JM, McBride WJ (2008) Effects of short deprivation and re-exposure intervals on the ethanol drinking behavior of selectively bred high alcohol-consuming rats. Alcohol 42: 407-416.

160. Toalston JE, Oster SM, Kuc KA, Pommer TJ, Murphy JM, Lumeng L, Bell RL, McBride WJ, Rodd ZA. (2008) Effects of alcohol and saccharin deprivations on concurrent ethanol and saccharin operant self-administration by alcohol-preferring (P) rats. Alcohol 42: 277-284

161. Engleman EA, Ingraham CM, Franklin KM, Keith CM, McClaren JA, Schultz JA, Morzorati SL, O’Conner S, Thielen RJ, Murphy JM, McBride WJ (2008) In vivo time-course changes in ethanol levels sampled with subcutaneous microdialysis. Alcoholism: Clinical and Experimental Research, 32: 435-442.

162. Bell RL, Rodd ZA, Toalston JE, McKinzie DL, Lumeng L, Li TK, McBride WJ, Murphy JM (2008) Autonomic activation associated with ethanol self-administration in adult female P rats. Pharmacol Biochem Behav. 91:223-232.

163. Engleman EA, Rodd ZA, Bell RL and Murphy JM (2008) The role of 5-HT3 receptors in drug abuse and as a target for pharmacotherapy. CNS & Neurological Disorders - Drug Targets, 7: 454-467.

164. Rodd ZA, Bell RL, Kuc KA, Murphy JM, Lumeng L, McBride WJ. (2009) Effects of concurrent access to multiple ethanol concentrations and repeated deprivations on alcohol intake of high-alcohol-drinking (HAD) rats. Addiction Biology 14: 152-164.

James M. Murphy 21 Manuscripts in Press Franklin KM, Engleman EA, Ingraham CM, McClaren JA, Keith CM; McBride WJ and Murphy JM (in

press) A single, moderate ethanol exposure alters Extracellular dopamine levels and dopamine D2 receptor function in the nucleus accumbens of Wistar rats. Alcoholism: Clinical and Experimental Research

Manuscripts Submitted for Publication or Under Revision Engleman EA, Ding Z-M, Oster SM, Toalston JE, Bell RL, Murphy JM, McBride WJ and Rodd ZA (under

revision) Ethanol is Self-Administered into the Nucleus Accumbens Shell, but not the Core: Evidence of Genetic Sensitivity. Alcoholism: Clinical and Experimental Research

James M. Murphy 22 Published Abstracts and Presentations at Professional Meetings 1. Murphy, J.M., and Culbertson, J.L. (1971). Failure to find escape from noncontingent positive brain

stimulation in rats. Presented at the annual meeting of the Eastern Psychological Association, New York, NY.

2. Murphy, J.M., and Nagy, Z.M. (1975). Acceleration of central nervous system maturation results in earlier onset of memory capacities in neonatal mice. Presented at the annual meeting of the Midwestern Psychological Association, Chicago, IL.

3. Gold, P.E., and Murphy, J.M. (1979). Brain norepinephrine and retrograde amnesia. Society for Neuroscience Abstracts 5: 316.

4. Murphy, J.M., Cooley, S.G., and Gold, P.E. (1979). Enhancement of 24-hour retention in preweanling rats by post-training hormone administration. Society for Neuroscience Abstracts 5: 321.

5. Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1980). The effects of chronic alcohol consumption on the levels of monoamines in different CNS regions of alcohol-preferring rats. Society for Neuroscience Abstracts 6: 610.

6. Flint, R.S., Murphy, J.M., Cinancone, M.T., and McBride, W.J. (1981). In vitro release of endogenous dopamine and 3,4-dihydroxyphenylacetic acid from rat striatum. Society for Neuroscience Abstracts 7: 198.

7. McBride, W.J., Flint, R.S., Ciancone, M.T., and Murphy, J.M. (1981). In vitro release of endogenous monoamines and amino acids from nine CNS regions. Society for Neuroscience Abstracts 7: 199.

8. Murphy, J.M., McBride, W.J., Ciancone, D.J., Lumeng, L., and Li, T.-K. (1981). The effect of chronic alcohol consumption on neurotransmitter systems in alcohol-preferring rats. Society for Neuroscience Abstracts 7: 314.

9. Flint, R.S., Calkins, P.M., Murphy, J.M., and McBride, W.J. (1982). Transmitter interactions assessed by changes of endogenous release. Transactions of the American Society for Neurochemistry 13: 278.

10. McBride, W.J., and Murphy, J.M. (1984). Effects of ethanol on monoamine and amino acid release. Alcoholism: Clinical and Experimental Research 8: 106.

11. Murphy, J.M., Waller, M.B., McBride, W.J., Lumeng, L., and Li, T.-K. (1984). Serotonin and norepinephrine uptake inhibitors attenuate ethanol intake in the P (alcohol-preferring) line of rats. Alcoholism: Clinical and Experimental Research 8: 109.

12. McBride, W.J., Murphy, J.M., Lumeng, L., and Li, T.-K. (1985). Effects of ethanol on transmitter release from cortical slices of P rats. Alcoholism: Clinical and Experimental Research 9: 207.

13. McBride, W.J., Murphy, J.M., Waller,M.B., Lumeng, L., and Li, T.-K. (1985). Neurochemical evidence for the development of neuronal tolerance in the alcohol-preferring P line of rats. Society for Neuroscience Abstracts 11: 291.

14. Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1985). CNS amino acid transmitter levels in P (alcohol-preferring) rats and effects of ethanol. Alcoholism: Clinical and Experimental Research 9: 207.

15. Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1985). Regional brain serotonin content in alcohol-preferring and -nonpreferring rats from the N/Nih heterogeneous stock. Society for Neuroscience Abstracts 11: 290.

16. Waller, M.B., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1985). Studies on the reinforcing properties of ethanol in alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental Research 9: 207.

17. Gatto, G.J., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1986). Acquisition of tolerance to ethanol through free-choice drinking in alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental Research 10: 111.

18. Gatto, G.J., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1986). Persistence of acute tolerance in alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental Research 10: 111.

19. Li, T.-K., Lumeng, L., McBride, W.J., and Murphy, J.M. (1986). Different alcohol-evoked responses in rodent lines selected for high and low voluntary alcohol drinking. Third congress of the International Society for Biomedical Research on Alcoholism, Helsinki, Finland, June 25-30.

20. McBride, W.J., Murphy, J.M., Lumeng, L., and Li, T.-K. (1986). Levels of monoamines and metabolites in the nucleus accumbens and frontal cortex of selectively bred alcohol preferring and nonpreferring lines of rats. Society for Neuroscience Abstracts 12: 1143.

James M. Murphy 23 21. Murphy, J.M., Gongwer, M., Elsner, G., and McBride, W.J. (1986). Acute ethanol intoxication

decreases aspartate content in the CNS of Wistar rats. Alcoholism: Clinical and Experimental Research 10: 117.

22. Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1986). Acute ethanol intoxication elevates regional brain monoamine metabolites in the Wistar rat. Alcoholism: Clinical and Experimental Research 10: 117.

23. Gatto, G.J., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1987). The effects of fluoxetine on ethanol intake in the alcohol-nonpreferring (NP) line of rats. Society for Neuroscience Abstracts 13: 338.

24. Khatib, S.A., Murphy, J.M., and McBride, W.J. (1987). Differential effects of acute ethanol on the dopaminergic and serotonergic systems in rat brain. Alcoholism: Clinical and Experimental Research 11: 203.

25. McBride, W.J., Murphy, J.M., Lumeng, L., and Li, T.-K. (1987). Involvement of monoamines in drinking behavior of selectively bred alcohol-preferring rats. Presented at the 95th annual meeting of the American Psychological Association, New York, NY, August 28-September 1.

26. Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1987). Effects of serotonergic agents on ethanol intake of the high alcohol drinking (HAD) line of rats. Alcoholism: Clinical and Experimental Research 11: 208.

27. Murphy, J.M., Morzorati, S.L., Hingtgen, J.N., Matney, S.L., Lumeng, L., and Li, T.-K. (1987). Response suppression to serotonergic drugs is attenuated in the P line of alcohol-preferring rats. Society for Neuroscience Abstracts 13: 340.

28. Gongwer, M.A., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1988). Absence of tolerance in monoamine systems to acute ethanol in the alcohol-preferring P line of rats. Alcoholism: Clinical and Experimental Research 12: 308.

29. Gongwer, M., Murphy, J.M., and McBride, W.J. (1988). Effect of Ro15-4513 on acute ethanol-induced changes in intoxication score, ambulatory activity and monoamine metabolite levels. Society for Neuroscience Abstracts 14: 521.

30. Levy, A.D., McBride, W., Murphy, J., Lumeng, L., and Li, T.-K. (1988). Genetically selected lines of high- and low-alcohol-drinking rats: Operant studies. Society for Neuroscience Abstracts 14: 41.

31. Li, T.-K., Lumeng, L., Froehlich, J.C., Murphy, J.M., and McBride, W.J. (1988). Genetic influence on response to the reinforcing properties of ethanol in rats. Fourth Congress of the International Society for Biomedical Research on Alcoholism Abstracts, Kyoto, Japan, June 26-July 2.

32. Li, T.-K., Lumeng, L., McBride, W.J., Murphy, J.M., Froehlich, J.C., and Morzorati, S. (1988). Behavioral and neurochemical associations of alcohol-seeking behavior. Fourth Congress of the International Society for Biomedical Research on Alcoholism Abstracts, Kyoto, Japan, June 26-July 2.

33. McBride, W.J., Murphy, J.M., Lumeng, L., and Li, T.-K. (1988). Effects of Ro 15-4513 on ethanol intake of the alcohol-preferring P line of rats. Alcoholism: Clinical and Experimental Research 12: 315.

34. Murphy, J.M., Gongwer, M.A., McBride, W.J., Lumeng, L., and Li, T.-K. (1988). Contents of serotonin, dopamine and their metabolites in the CNS of high- and low-alcohol-drinking lines of rats. Society for Neuroscience Abstracts 14: 195.

35. Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1988). Effects of serotonin and dopamine agents on ethanol intake of alcohol-preferring P rats. Alcoholism: Clinical and Experimental Research 12: 306.

36. Engleman, E.A., Hingtgen, J.N., Zhou, F.C., Murphy, J.M., and Aprison, M.H. (1989). Potentiated 5-hydroxytryptophan (5-HTP) response suppression following 5,7-dihydroxytryptamine (5,7-DHT) raphe lesions in rats tested in a model of depression. Society for Neuroscience Abstracts 15: 1282.

37. Gatto, G.J., Murphy, J.M., McBride, W.J., Lumeng, L. and Li, T.-K. (1989). Persistence of acute tolerance to ethanol in the P line of rats does not require performance while intoxicated. Society for Neuroscience Abstracts 15: 38.

38. Gatto, G.J., McBride, W.J., Murphy, J.M., Lumeng, L., and Li, T.-K. (1989). Effects of serotonin (5HT) agonists on alcohol drinking behavior of the NP (alcohol-nonpreferring) line of rats. Alcoholism: Clinical and Experimental Research 13: 305.

39. Gatto, G.J., Murphy, J.M., Stewart, R.B., McBride, W.J., Lumeng, L., and Li, T.-K. (1989). Passive avoidance behavior in alcohol-preferring and -nonpreferring lines of rats. Alcoholism: Clinical and Experimental Research 13: 306.

James M. Murphy 24 40. Levy, A.D., McBride, W.J., Murphy, J.M., Lumeng, L., and Li, T.-K. (1989). Effects of

intra-accumbens infusions of DA and 5-HT on ethanol intake of alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental Research 13: 305.

41. Levy, A.D., Murphy, J.M., McBride, W.J., Lumeng, L. and Li, T.-K. (1989). Microinjection of the serotonin agonist TFMPP into the nucleus accumbens increases ethanol drinking in P rats. Society for Neuroscience Abstracts 15: 59.

42. Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1989). Effects of spiroxatrine on the fluoxetine-induced reduction of ethanol intake by alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental Research 13: 305.

43. Murphy, J.M., McBride, W.J., Lumeng, L., Li, T.-K. and Wong, D.T. (1989). Suppression of alcohol and food intake by LY264453, a new inhibitor of serotonin (5HT) and norepinephrine (NE) uptake. Society for Neuroscience Abstracts 15: 58.

44. Stewart, R.B., Murphy, J.M., Lumeng, L., and Li, T.-K. (1989). Differences in performance on anxiety tests in rats genetically selected for ethanol preference. Society for Neuroscience Abstracts 15: 61.

45. Zhou, F.C. and Murphy, J.M. (1989). A serotonergic neurotrophic factor is induced by lesioning dopamine neurons in substantia nigra of adult rat. Society for Neuroscience Abstracts 15: 1363.

46. Engleman, E.A., Hingtgen, J.N., Murphy, J.M., Zhou, F.C., and Aprison, M.H. (1990). Attenuated 5-hydroxytryptophan (5-HTP) induced response suppression following pretreatment with a selective 5-HT2 receptor agonist (DOI) in an animal model of depression. Society for Neuroscience Abstracts 16: 850.

47. Gatto, G.J., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1990). Intracranial self-administration of ethanol into the ventral tegmental area of alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental Research 14: 291.

48. Gatto, G.J., Murphy, J.M., Stewart, R.B., and McBride, W.J. (1990). Passive avoidance behavior in alcohol-preferring and -nonpreferring lines of rats. Society for Neuroscience Abstracts 16: 434.

49. Levy, A.D., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1990). 5-HT3 but not 5-HT2 receptors in the nucleus accumbens may mediate alcohol drinking in alcohol-preferring (P) rats. Society for Neuroscience Abstracts 16: 258.

50. Levy, A.D., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1990). Microinjection of sulpiride into the nucleus accumbens increases ethanol drinking in alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental Research 14: 321.

51. McBride, W.J., Murphy, J.M., Lumeng, L., and Li, T.-K. (1990). Serotonin and dopamine systems regulating alcohol intake. Presented at the joint meeting of the International Society for Biomedical Research on Alcoholism and the Research Society on Alcoholism. Toronto, Ontario, Canada, June 17-22.

52. Murphy, J.M., Engleman, E., Burns, S., McBride, W.J., and Hingtgen, J.N. (1990). Operant response suppression by the 5HT2 agonist DOI in alcohol-preferring (P) and -nonpreferring (NP) rats. Society for Neuroscience Abstracts 16: 434.

53. Stewart, R.B., Murphy, J.M., Lumeng, L., and Li, T.-K. (1990). Performance on the plus-maze test of anxiety in Wistar, alcohol-preferring (P) and -nonpreferring (NP) lines of rats: Effects of ethanol and chlordiazepoxide (CDP). Society for Neuroscience Abstracts 16: 756.

54. Stewart, R.B., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1990) Tolerance to the aversive effects of ethanol in selectively-bred alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental Research 14: 342.

55. Engleman, E.A., Hingtgen, J.N., Murphy, J.M., Zhou, F.C., and Aprison, M.H. (1991). LY53857 blocks response suppression (RS) induced with 5-HTP and DOI but not with 8-OH-DPAT in an animal model of depression. Society for Neuroscience Abstracts 17: 281.

56. Gatto, G.J., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1991). Ethanol-associated conditioned reinforcement in alcohol- preferring (P) rats. Alcoholism: Clinical and Experimental Research 15: 313.

57. Murphy, J.M., Gatto, G.J., Dean, R.A., and Bosron, W.F. (1991). Intracranial self-administration (ICSA) of ethylcocaine (EC), an active metabolite of ethanol and cocaine, to the prefrontal cortex in rats. Alcoholism: Clinical and Experimental Research 15: 315.

58. Murphy, J.M., Stewart, R.B., Lumeng, L., Li, T.-K., and McBride, W.J. (1991). Effects of serotonergic agents on ethanol drinking in the P line of alcohol-preferring rats. Society for Neuroscience Abstracts 17: 1424.

James M. Murphy 25 59. Stewart, R.B., Li, T.-K., McBride, W.J., Lumeng, L., and Murphy, J.M. (1991). Chronic tolerance in

ethanol-preferring P rats and enhanced responsiveness in ethanol-nonpreferring NP rats to the effects of ethanol on spontaneous motor activity (SMA). Alcoholism: Clinical and Experimental Research 15: 317.

60. Stewart, R.B., Russell, R.N., Franada, F., and Murphy, J.M. (1991). Effects of amphetamine and scopolamine on motor activity in alcohol-preferring (P) and -nonpreferring (NP) rats. Society for Neuroscience Abstracts 17: 1424.

61. Dyr, W., McBride, W.J., Lumeng, L., Li, T.-K., and Murphy, J.M. (1992). The effects of D1 and D2 dopamine receptor agents on ethanol consumption in the HAD line of high alcohol drinking rats. Alcoholism: Clinical and Experimental Research 16: 396.

62. Engleman, E.A., Murphy, J.M., Zhou, F.C., Aprison, M.H., and Hingtgen, J.N. (1992). Operant response suppression (RS) induced with systemic administration of 5-hydroxytryptophan (5-HTP) is centrally mediated. Society for Neuroscience Abstracts 18: 1536.

63. Gatto, G.J., Murphy, J.M., Lumeng, L., Li, T.-K., and McBride, W.J. (1992). Effect of environmental cues on intracranial self- administration (ICSA) of ethanol into the ventral tegmental area (VTA) in alcohol-preferring (P) rats. Presented at the 18th annual Convention of the Association for Behavior Analysis: International. San Francisco, CA, May 24-28.

64. Gatto, G.J., Murphy, J.M., Lumeng, L., Li, T.-K., and McBride, W.J. (1992). Extinction of intracranial self-administration (ICSA) of ethanol into the ventral tegmental area (VTA) in alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental Research 16: 367.

65. Godfrey, C.D., Jing, S.L., Stewart, R.B., Froehlich, J.C., and Murphy, J.M. (1992). Comparison of alcohol-preferring (P) and -nonpreferring (NP) rats in a forced-swims stress test. Society for Neuroscience Abstracts 18: 541.

66. Godfrey, C.D., Stewart, R.B., McBride, W.J., Lumeng, L., Li, T.-K., and Murphy, J.M. (1992). The effects of 8-OH-DPAT on behavioral activity in the alcohol-preferring P and -nonpreferring NP rats. Alcoholism: Clinical and Experimental Research 16: 406.

67. Lovell, T.A., Engleman, E.A., Aprison, M.H., Hingtgen, J.N., and Murphy, J.M. (1992). 5-HT1A receptor agonist and antagonist effects on suppression of responding in a model of depression. Society for Neuroscience Abstracts 18: 1536.

68. McBride, W.J., Murphy, J.M., Levy, A.D., Gatto, G.J., Yoshimoto, K., Lumeng, L., and Li, T.-K. (1992). CNS mechanisms of alcohol drinking in genetically selected lines of rats. Presented at the Sixth Congress of the International Society for Biomedical Research on Alcoholism. Bristol, England, June 21-26.

69. McBride, W.J., Murphy, J.M., Lumeng, L., and Li, T.-K. (1992). Serotonin regulation of alcohol drinking. Presented at the Second International Symposium on Serotonin from Cell Biology to Pharmacology and Therapeutics. Houston, Texas, September 15-18.

70. Murphy, J.M., McBride, A.W., Wlodarek, C.A., McBride, W.J., Lumeng, L., and Li, T.-K. (1992). Differences in the ontogeny of locomotor activity between the alcohol-preferring P and -nonpreferring NP rats. Alcoholism: Clinical and Experimental Research 16: 406.

71. Stewart, R.B., Li, T.-K., McBride, W.J., Lumeng, L., and Murphy, J.M. (1992). Chronic ethanol consumption in alcohol-preferring P rats attenuates subsequent conditioned place aversion produced by ethanol injections. Alcoholism: Clinical and Experimental Research 16: 395.

72. Stewart, R.B., Li, T.-K., McBride, W.J., Lumeng, L., and Murphy, J.M. (1992). Place aversion conditioning: Genetic differences in the aversive effects of ethanol in alcohol-preferring P and -nonpreferring NP rats. Alcoholism: Clinical and Experimental Research 16: 395.

73. Stewart, R.B., Russell, R.N., Li, T.-K., and Murphy, J.M. (1992). Consumption of sweet, salty, sour and bitter flavored solutions by selectively-bred alcohol-preferring P and -nonpreferring NP lines of rats. Society for Neuroscience Abstracts 18: 541.

74. Dyr, W., Cox, R., McBride, W.J., Lumeng, L., Li, T.-K., and Murphy, J.M. (1993). Operant responding for ethanol in high HAD and low LAD alcohol-drinking rats. Alcoholism: Clinical and Experimental Research 17: 479.

75. Dyr, W., McBride, W.J., Murphy, J.M., Lumeng, L., and Li, T.-K. (1993). Multiple injections of 5-HT antagonists reduce alcohol consumption of the P line of rats. Alcoholism: Clinical and Experimental Research, 17: 482.

76. June, H.L., Green, T., Murphy, J.M., Lumeng, L., and Li, T.-K. (1993). Ro19-4603 selectively attenuates ethanol intake in the alcohol-preferring P rats. Alcoholism: Clinical and Experimental Research, 17: 481.

James M. Murphy 26 77. Murphy, J.M., Dyr, W., McBride, W.J., Lumeng, L., and Li, T.-K. (1993). Sensitivity and tolerance to

the sedative effects of ethanol in the high- and low-alcohol-drinking (HAD and LAD) rats. Society for Neuroscience Abstracts 19: 1455.

78. Zhou, F.C., Murphy, J., Lumeng, L., and Li, T.-K. (1993). Relationship of dopaminergic and serotonergic neurons from raphe to nucleus accumbens in alcohol-preferring rats. Alcoholism: Clinical and Experimental Research, 17: 479.

79. Chamberlain, J.K., Murphy, J.M., Lumeng, L., Li, T.-K., and McBride, W.J. (1994). Involvement of serotonergic systems in sensitivity to ethanol. Alcoholism: Clinical and Experimental Research 18: 483.

80. Hewitt, R.L., June, H.L., Murphy, J.M., Mellor-Burke, J.J., Greene, T.L., Lin, M., Lumeng, L., and Li, T.-K. (1994). Does tolerance develop to the ethanol suppressant effects of the benzodiazepine inverse agonist, RO19-4603? Alcoholism: Clinical and Experimental Research 18: 487.

81. Ikemoto, S., Murphy, J.M., Lumeng, L., Li, T.-K., and McBride, W.J. (1994). Ethanol self-administration into the VTA of the P rats using fixed ratio schedules. Alcoholism: Clinical and Experimental Research 18: 518.

82. June, H.L., Chen, S.H.A., Duemler, S., Lin, M., Greene, T.L., Williams, J., Hewitt, R.L., Mellor-Burke, J.J., Lewis, M.J., and Murphy, J.M. (1994). Effects of RO19-4603 on the maintenance of tolerance to a single dose of ethanol. Alcoholism: Clinical and Experimental Research 18: 521.

83. June, H.L., Murphy, J.M., Hewitt, R.L., Greene, T.L., Lin, M., Mellor-Burke, J.J., Chen, S.H.A., Lumeng, L., and Li, T.-K. (1994). Benzodiazepine receptor ligands with different intrinsic efficacies alter ethanol intake in alcohol-nonpreferring (NP) rats. Alcoholism: Clinical and Experimental Research 18: 487.

84. Katner, S.N., McBride, W.J., Lumeng, L., Li, T.-K., and Murphy, J.M. (1994). Muscarinic receptor involvement in alcohol drinking and behavioral activity of P and NP rats. Alcoholism: Clinical and Experimental Research 18: 487.

85. Russell, R.N., Froehlich, J.C., Stewart, R.B., Lumeng, L., Li, T.-K., and Murphy, J.M. (1994). Comparison of alcohol-preferring P and -nonpreferring NP rats for the intravenous self-administration (IVSA) of cocaine. Alcoholism: Clinical and Experimental Research 18: 519.

86. Russell, R.N., McBride, W.J., Lumeng, L., Li, T.-K., and Murphy, J.M. (1994). Effects of dopamine D3 and D4 receptor agonists on ethanol consumption in high alcohol drinking (HAD) and alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental Research 18: 488.

87. Duemler, S., June, H.L., Breen, T.E., Lewis, M.J., and Murphy, J.M. (1994). The benzodiazepine inverse agonist RO19-4603 exerts prolonged antagonism of the locomotor depressant actions of ethanol in alcohol-preferring (P) rats. Society for Neuroscience Abstracts 20: 499.

88. June, H.L., Greene, T.L., Lin, M., and Murphy, J.M. (1994). Differential sensitivity of the benzodiazepine inverse agonist RO19-4603 on the locomotor depressant effects of ethanol in alcohol-preferring (P) and -nonpreferring (NP) rats. Society for Neuroscience Abstracts 20: 1606.

89. Williams, J., June, H.L., Dejaravu, S., Lewis, M.J., and Murphy, J.M. (1994). The benzodiazepine anatangonist CGS-8216 exerts prolonged and selective attenuation of ethanol intake in alcohol-preferring (P) rats. Society for Neuroscience Abstracts 20: 1606.

90. McKinzie, D.L., Eha, R., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1994). Early taste aversion training is effective in preventing the onset of alcohol drinking in P and HAD rat lines. Society for Neuroscience Abstracts 20: 1609.

91. Godfrey, C.D., Froehlich, J.C., Lumeng, L., Li, T.-K., and Murphy, J.M. (1994). Immobility in a swim test is not associated with a genetic predisposition to alcohol preference. Society for Neuroscience Abstracts 20: 1618.

92. June, H.L., Lewis, M.J., Murphy, J.M., Lumeng, L., and Li, T.-K. (1994). The benzodiazepine antagonists CGS-8216 and ZK 93426 attenuate ethanol intake in alcohol preferring (P) rats. American College of Neuropsychopharmacology Abstracts, 133.

93. June, H.L., Murphy, J.M., Lewis, M.J., Lumeng, L., and Li, T.-K. (1994). Differential sensitivity of the benzodiazepine inverse agonist RO19-4603 on the locomotor depressant effects of ethanol in low and high drinking F2 rats. American College of Neuropsychopharmacology Abstracts, 132.

94. Ikemoto, S., Glazier, B.S., Murphy, J.M., and McBride, W.J. (1995). Muscarinic receptors in the nucleus accumbens mediate a reinforcing effect. Society for Neuroscience Abstracts 21: 1673.

95. Ikeomoto, S., McBride, W.J., Murphy, J.M., Lumeng, L., and Li, T.-K. (1995). Effects of 6-OHDA lesions of the nucleus accumbens (ACB) on the acquisition and maintenance of alcohol drinking in the aP line of rats. Alcoholism: Clinical and Experimental Research 19: 13A.

James M. Murphy 27 96. June, H.L., Williams, J., Cason, C.R., Devaraju, S., Lin, M., Murphy, J.M., Lewis, M.J., Lumeng, L.,

and Li, T.-K. (1995). Low doses of gamma-hydroxybutyric acid (GHB) attenuate ethanol intake in alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental Research 19: 14A.

97. June, H.L., Murphy, J.M., Lewis, M.J. and Li, T.-K. (1995). The novel benzodiazepine partial inverse agonist RO19-4603 produces selective and prolonged suppression of ethanol (EtOH) intake and ethanol-reinforced responding in alcohol-preferring (P) rats. American College of Neuropsychopharmacology 34: 96.

98. June, H.L., Cason, C.R., Braun, M.R., Torres, L., Allen, A., DeLong, J., Jackson, D., Murphy, J.M., Lewis, M.J., Lumeng, L., and Li, T.-K. (1995). Bretazenil exerts anxiolytic effects in alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental Research 19: 65A.

99. Katner, S.N., McBride, W.J., Lumeng, L., Li, T.-K., and Murphy, J.M. (1995). Effects of nicotinic agents on alcohol drinking and locomotor activity of P and NP rats. Alcoholism: Clinical and Experimental Research 19: 12A.

100. Katner, S.N. McBride, W.J., Lumeng, L., Li, T.-K., and Murphy, J.M. (1995). Involvement of the pedunculopontine nucleus in regulating alcohol drinking. Society for Neuroscience Abstracts 21: 1699.

102. Lewis, M.J., June, H.L., Murphy, J.M., and Li, T.-K. (1995). Evaluation of high affinity benzodiazepine partial agonists in alcohol-preferring (P) and nonpreferring (NP) rats. American College of Neuropsychopharmacology 34: 195.

103. Li, T.-K., Lumeng, L., McBride, W.J., and Murphy, J.M. (1995). A pharmacogenetic rat model of alcholism. American College of Neuropsychopharmacology 34: 12.

104. McBride, W.J., Cox, R., Eha, R., McKinzie, D.L., Lumeng, L., Li, T.-K., and Murphy, J.M., (1995). Possible involvement of 5-HT-3 receptors in the anticipatory behavior of P rats for alcohol. Alcoholism: Clinical and Experimental Research 19: 14A.

105. McKinzie, D.L., Cox, R., McBride, W.J., Lumeng, L., Li, T.-K., and Murphy, J.M. (1995). Postnatal development of alcohol drinking behavior in P, NP and Wistar rats. Alcoholism: Clinical and Experimental Research 19: 16A.

106. McKinzie, D.L., Eha, R., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1995). Ontogeny of rapid tolerance to ethanol in high alcohol drinking (HAD) and low alcohol drinking (LAD) rats. Presented at the International Society for Developmental Psychobiology, San Diego, CA.

107. Craig, K., June, H.L., Braun, M.R., and Murphy, J.M. (1996). Benzodiazepine receptor antagonists modulate the behavioral actions of ethanol. Alcoholism: Clinical and Experimental Research 20: 12A.

108. Zuccarelli, D., June, H.L., Durr, L.F., and Murphy, J.M. (1996). Benzodiazepine receptor antagonists with different intrinsic efficacies modulate ethanol-reinforced responding in alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental Research 20: 12A.

109. Cason, C.R., June, H.L., Matecka, D., and Murphy, J.M. (1996). Effects of the selective, high affinity ligand ZG-63 for diazepam insensitive subtype of the benzodiazepine receptor on EtOH-reinforced responding. Alcoholism: Clinical and Experimental Research 20: 12A.

110. Eggers, M.W., June, H.L., Ricks, D., and Murphy, J.M. (1996). The novel benzodiazepine agonist RU 34000 and specific antagonist RU 40410 antagonize ethanol -reinforced responding in alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental Research 20: 12A.

111. McKinzie, D.L., Eha, R., McBride, W.J., Murphy, J.M., Lumeng, L., and Li, T.-K. (1996). Evidence for neuroadaptive changes that occur during abstinence and promote alcohol relapse. Alcoholism: Clinical and Experimental Research 20: 15A.

112. McKinzie, D.L., Alexander, D., Eha, R., McBride, W.J., Murphy, J.M., Lumeng, L., and Li, T.-K. (1996). Effects of amphetamine on motor activity in periadolescent alcohol-preferring (P) and -nonpreferring (NP) rats. Alcoholism: Clinical and Experimental Research 20: 23A.

113. Ikemoto, S., Murphy, J.M., and McBride, W.J. (1996). Activation of GABAA receptors within mesencephalic raphe nuclei mediates operant reinforcement. Alcoholism: Clinical and Experimental Research 20: 61A.

114. Ikemoto, S., Glazier, B.S., Murphy, J.M., and McBride, W.J. (1996). Self-infusion of D1 and D2 agonists into the nucleus accumbens of rats. Society for Neuroscience Abstracts 22:

115. McKinzie, D.L.,Sajdyk, T.J., Murphy, J.M., McBride, W.J., Lumeng, L., Li, T.-K., and Shekhar, A. (1996). Startle and fear-potentiated startle responding in the alcohol-preferring ( P) and non-preferring (NP) rat. Society for Neuroscience Abstracts 22: 2071.

James M. Murphy 28 116. June, H.L., Murphy, J.M., Froehlich, J.C., Lewis, M.J., and Lumeng, L. (1996). Characterization of

nalmefene, the 6-methylene derivative of naltrexone on ethanol reinforced behaviors. American College of Neuropsychopharmacology 35: 164.

117. June, H.L., Murphy, J.M., Matecka, D., Lewis, M.J., and Lumeng, L. (1996). Gabaergic transmission in the mesoaccumbens is involved in alcohol self-administration in alchol-preferring (P) rats. American College of Neuropsychopharmacology 35: 224.

118. Goodlett, C.R., McKinzie, D.L., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1997). Comparison of morris maze place learning in juvenile rats of the HAD and LAD selected lines. Alcoholism: Clinical and Experimental Research 21: 17A.

119. McKinzie, D.L., McBride, W.J., Murphy, J.M., Lumeng, L., and Li, T.-K. (1997). The effects of 5-HT3 receptor antagonists on operant responding for ethanol in alchol-preferring (P) rats. Alcoholism: Clinical and Experimental Research 21: 107A.

120. McKinzie, D.L., Eha, R., McBride, W.J., Murphy, J.M., Lumeng, L., and Li, T.-K. (1997). Effects of high dose ethanol and the development of tolerance in high alcohol-drinking (HAD) and low alcohol-drinking (LAD) lines of rats. Alcoholism: Clinical and Experimental Research 21:42A.

121. McKinzie, D.L., Cox, R., McBride, W.J., Stewart, R.B., Murphy, J.M., Lumeng, L., and Li, T.-K. (1997). Sensitivity and rapid tolerance to the sedative effects of penobarbital in alcohol-preferring (P) and -nonpreferring NP rats. Alcoholism: Clinical and Experimental Research 21: 42A.

122. Nowak, K.L., McKinzie, D.L., McBride, W.J., Murphy, J.M., Lumeng, L., and Li, T.-K. (1997). The development of alcohol-drinking behavior in single- and pair-housed alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental Research 21: 108A.

123. Nowak, K.L., Brenneman, M.G., Dagon, C.L., McBride, W.J., Lumeng, L., Li, T.-K., and Murphy, J.M. (1997). Blocking GABA-A receptors in the anterior VTA attenuates ethanol intake of the alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental Research 21: 74A.

124. Nowak, K.L., McKinzie, D.L., McBride, W.J., Murphy, J.M., Lumeng, L., and Li, T.-K. (1997). Patterns of operant responding for and drinking of ethanol and saccharin in P rats using a 2-hr alternate-day-access schedule. Alcoholism: Clinical and Experimental Research 21:11A.

125. Nowak, K.L., McKinzie, D.L., McBride, W.J., Murphy, J.M., Lumeng, L., and Li, T.-K. (1997). Heightened response to novelty in the alcohol-preferring P rat. Alcoholism: Clinical and Experimental Research 21:15A.

126. Stewart, R.B., Murphy, J.M., Lumeng, L., and Li, T.-K. (1997). Sweet preference and spontaneous motor activity are correlated with alcohol intake in the F2 progeny of an alcohol-preferring (P) and -nonpreferring (NP) rat cross. Alcoholism: Clinical and Experimental Research 21: 16A.

127. McKinley, P.J., Meisch, R.A., Murphy, J.M., and Stewart, R.B. (1997). Choice between concurrently-available oral ethanol doses: Effects of fixed-ratio schedule and body-weight reduction. Alcoholism: Clinical and Experimental Research 21: 12A.

128. June, H.L., Lewis, M.J., and Murphy, J.M. GABAergic transmission in the meso-accumbens is involved in ethanol motivated behaviors. Presented at the 41st annual meeting of the Behavioral Pharmacology Society, Philadelphia, Pennsylvania, May 30-31. 1997.

129. Cason, C.R., June, H.L., Fredericks, M., Cheatham, G., Chen, A., Cook, J., Gan, T., and Murphy, J.M. (1997) Gabaergic regulation of the reinforcing properties of alcohol in Wistar rats. Society for Neuroscience Abstracts 23: 959

130. June, H.L., Cheatham, G., Fredericks, M., Cason, C.R., Chen, A., Cook, J., Gan, T., and Murphy, J.M. (1997) Gabaergic regulation of the sedative properties of alcohol in the striatum of Wistar rats. Society for Neuroscience Abstracts 23: 958

131. Mckinzie, D.L., Glazier, B.S., Murphy, J.M., Li, T.-K., Lumeng, L., and McBride, W.J. (1997) cocaine is self-administered into the anterior nucleus accumbens shell region of alcohol-preferring rats. Society for Neuroscience Abstracts 23: 1105.

132. McKinzie, D.L., Dagon, C.L., McBride, C.L., Murphy, J.M., Lumeng, L., Li, T.-K., and Shekhar, A. Enhanced disruption of prepulse inhibition in P versus NP rats following low-dose ethanol administration. Presented at the World congress on Psychiatric Genetics. Santa Fe, New Mexico, October 19-23, 1997.

133. McKinzie, D.L., Nowak, K.L., Dagon, C.L., Rodd, Z.A., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1998). Behavioral sensitization to repeated cocaine administrations in the alcohol-preferring (P) and alcohol-nonpreferring (NP) rat lines. Alcoholism: Clinical and Experimental Research 22: 99A.

James M. Murphy 29 134. McKinzie, D.L., Dagon, C.L., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1998). The

effects of acamprosate on ethanol-reinforced responding in the alcohol-preferring (P) rat. Alcoholism: Clinical and Experimental Research 22: 14A.

135. Nowak, K.L., McKinzie, D.L., Dagon, C.L., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1998). Differences in an operant measurement of impulsivity between alcohol-preferring (P) and alcohol-nonpreferring (NP) rats. Alcoholism: Clinical and Experimental Research 22: 54A.

136. Nowak, K.L., Crile, R.S., McBride, W.J., Lumeng, L., Li, T.-K. and Murphy, J.M. (1998). Effects of manipulating dopamine D-2 receptors in the anterior VTA of the alcohol-preferring (P) rat. Alcoholism: Clinical and Experimental Research 22: 14A.

137. Rodd, Z.A., Nowak, K.L., McKinzie, D.L., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1998). Alcohol deprivation effect as a funciton of deprivation length and deprivation exposures in the alcohol-preferring (P) rat. Alcoholism: Clinical and Experimental Research 22: 15A.

138. Stewart, R.B., McKinley, P.J., Bottoms, D.M., Bottoms, N.A., and Murphy, J.M. (1998). Sensitivity and tolerance to the motor-impairing effects of ethanol in rats of the selectively bred high alcohol drinking (HAD) and low alcohol drinking (LAD) lines. Alcoholism: Clinical and Experimental Research 22: 91A.

139. Stewart, R.B., Murphy, J.M., and McKinley, P.J. (1998). Decreases in ethanol-maintained lever-press responding in rats following naloxone pretreatment: The effects of varying the available ethanol concentration. Alcoholism: Clinical and Experimental Research 22: 13A.

140. Stewart, R.B., Murphy, J.M., Lumeng, L., and Li, T.-K. (1998). Intake of saccharin solution in selectively-bred high and low alcohol drinking (HAD and LAD) lines of rats and in the F2 progeny of HAD and LAD rat crosses. Alcoholism: Clinical and Experimental Research 22: 55A.

141. Engleman, E.A., McBride, W.J., Wilber, A.A., Shaikh, S.R., Eha, R.D., Lumeng, L., Li, T.-K., and Murphy, J.M. (1998) Reverse microdialysis of dopamine (DA) uptake inhibitors into the nucleus accumbens (NAc) of alcohol preferring (P) rats: Effects on extracellular DA levels and ethanol (EtOH) intake. Society for Neuroscience Abstracts 24: 1478.

142. Nowak, K.L., Crile, R.S., McKinzie, D.L., Murphy, J.M. Lumeng, L., and Li, T.-K. Differences in measures of aggression in alcohol-preferring and non-preferring rat lines.(1998) Society for Neuroscience Abstracts 24: 748.

143. Rodd, Z.A., McKinzie, D.L., Dagon, C.L., Murphy, J.M. and McBride, W.J. (1998) Intracranial self-administration of ethanol into the posterior VTA by Wistar rats. Society for Neuroscience Abstracts 24: 1479.

144. McKinzie, D.L., Rodd, Z.A., Dagon, C.L., Murphy, J.M., and McBride, W.J. Cocaine is self-administered into the shell region of the nucleus accumbens in Wistar rats. Presented at the New York Academy of Sciences Conference: Advancing from the Ventral Striatuum to the Extended Amygdala: Implications for Neuropsychiatry and Drug Abuse. October 18-21, 1998 Charlottesville, VA.

145. Rodd-Henricks, Z.A., McKinzie, D.L., Li, T.-K., Murphy, J.M. and McBride, W.J. Regional heterogeneity within the rat ventral tegmental area for intracranial self-administration of alcohol. (1998) Presented at the annual meeting of the American College of Neuropsychopharmacology, December, 1998, Los Crobas, Puerto Rico.

146. Badia-Elder, N.E., Stewart, R.B., Woods, J.E., II, Powrozek, T.A., Murphy, J.M., Lumeng, L., and Li, T.-K. (1999) Ethanol-induced conditioned taste aversion in high alcohol drinking (HAD) and low alcohol drinking (LAD) rats. Alcoholism: Clinical and Experimental Research 23: 104A.

147. Bell, R.L., McKinzie, D.L., Murphy, J.M., and McBride, W.J. (1999) Assessing sensitivity and tolerance to the motor impairing effects of moderate doses of ethanol. Alcoholism: Clinical and Experimental Research 23: 98A.

148. Engleman, E.A., McBride, W.J., Wilber, A.A., Shaikh, S.R., Eha, R.D., Lumeng, L., Li, T.-K., and Murphy, J.M. (1999) Ethanol drinking experience potentiates the increase in extracellular dopamine (DA) in nucleus accumbens (NAc) with GBR12909 (GBR) in alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental Research 23: 48A.

149. Goodlett, C. R., McKinzie, D.L., Crile, R.S., Murphy, J.M., Lumeng, L., Li, T.-K ., and McBride, W.J. (1999) Alcohol induces dose-dependent impairments of spatial navigation learning in adolescent HAD and LAD rats. Alcoholism: Clinical and Experimental Research 23: 55A.

150. Jones, A.E., Crile, R.S., Murphy, J.M., McBride, W.J., Lumeng, L., Li, T.-K ., and McKinzie, D.L. (1999) Effects of background noise on habituation to the acoustic startle response in the alcohol preferring (P) and non-preferring (NP) rat. Alcoholism: Clinical and Experimental Research 23: 98A.

James M. Murphy 30 151. Jones, A.E., Dagon, C.T., Murphy, J.M., Lumeng, L., Li, T.-K ., McBride, W.J., Shekhar, A., and

McKinzie, D.L. (1999) Effects of fenfluramine and amphetamine on the startle reflex response in alcohol preferring (P) and nonpreferring (NP) lines of rats. Alcoholism: Clinical and Experimental Research 23: 104A.

152. Jones, A.E., Edmundson, V.E., Murphy, J.M., McBride, W.J., Lumeng, L., Li, T.-K ., and McKinzie, D.L. (1999) Effects of acute ethanol administration on body temperature ih high alcohol drinking (HAD) and low alcohol drinking (LAD) rats. Alcoholism: Clinical and Experimental Research 23: 99A.

153. McKinzie, D.L., Edmundson, V.E., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K . (1999) Oral acamprosate effects on ethanol-reinforced responding in the alcohol preferring (P) rat. Alcoholism: Clinical and Experimental Research 23: 20A.

154. McKinzie, D.L., Edmundson, V.E., Rodd-Henricks, Z.A., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K . (1999) Effects of acute and chronic cocaine on ethanol drinking and body temperature in alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental Research 23: 101A.

155. Nowak, K.L., McBride, W.J., Lumeng, L., Li, T.-K. and Murphy, J.M. (1999). Suppression of alcohol intake of the alcohol preferring P rat following dorsal raphe injections of 8-OH-DPAT. Alcoholism: Clinical and Experimental Research 23: 20A.

156. Rock, S., Neal-Belveau, B.S., and Murphy, J.M. (1999) Ethanol and cocaine interactive effect on local cerebral glucose utilization (LCGU). Alcoholism: Clinical and Experimental Research 23: 101A.

157. Rodd-Henricks, Z.A., McKinzie, D.L., Li, T.-K., Crile, R.S., Murphy, J.M., and McBride, W.J., (1999) Intracranial self-administration of ethanol into the posterior VTA of Wistar rats is mediated by 5-HT3 receptors. Alcoholism: Clinical and Experimental Research 23: 49A.

158. Rodd-Henricks, Z.A., McKinzie, D.L., Edmundson, V.E., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1999) Serotonin-3 receptor antagonists reduce alcohol intake during acquisition and maintenance but not following a period of alcohol deprivation in alcohol preferring (P) rats. Alcoholism: Clinical and Experimental Research 23: 49A.

159. Rodd-Henricks, Z.A., McKinzie, D.L., Shaikh, S.R., Edmundson, V.E., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (1999) The alcohol deprivation effect in high alcohol drinking (HAD) rat lines is dependent upon repeated deprivations. Alcoholism: Clinical and Experimental Research 23: 17A.

160. Stewart, R.B., Badia-Elder, N.E., Powrozek, T.A., Woods, J.E., II, Murphy, J.M., Lumeng, L., and Li, T.-K. (1999) comparisons of high alcohol drinking (HAD) and low alcohol drinking (LAD) rats on an elevated plus maze test of anxiety. Alcoholism: Clinical and Experimental Research 23: 105A.

161. Bell, R.L., Jones, A.E., McKinzie, D.L., McBride, W.J., and Murphy, J.M. (1999) Tolerance develops to the stimulation of heart rate by alcohol. Society for Neuroscience Abstracts, 25:1078

162. Rodd-Henricks, Z.A., McKinzie, D.L., Murphy, J.M., McBride, W.J., Lumeng, L. and Li, T.-K. (1999) Tolerance develops to the stimulation of heart rate by alcohol. Society for Neuroscience Abstracts, 25:1077

163. Smith, D.G., Learn, J.E., McBride, W.J., Lumeng, L., Li, T.-K., and Murphy, J.M. (1999) Local cerebral glucose utilization in alcohol-preferring P rats. Society for Neuroscience Abstracts, 25:1577

164. Smith, D.G., Learn, J.E., McBride, W.J., Lumeng, L., Li, T.-K., and Murphy, J.M. (1999) Local cerebral glucose utilization in alcohol-deprived and alcohol non-deprived alcohol-preferring P rats. Presented at the workshop meeting of the Indiana Alcohol Research Center and National Institute of Alcohol Abuse and Alcoholism meeting AAlcoholism: What Can Research Offer in the 21st Century@, Indianapolis, IN, December 8-9, 1999.

165. Badia-Elder, N.E., Stewart, R.B., Powrozek, T.A., Murphy, J.M., and Li, T.-K. (2000) Effects of neuropeptide Y (NPY) on ethanol intake and anxiety in high and low alcohol drinking (HAD/LAD) rats. Alcoholism: Clinical and Experimental Research 24: 82A.

166. Badia-Elder, N.E., Stewart, R.B., Powrozek, T.A., Roy, K.F., Murphy, J.M., and Li, T.-K. (2000) Effect of neuropeptide Y (NPY) on ethanol intake in Wistar, alcohol-preferring (P), and -nonpreferring (NP) rats. Alcoholism: Clinical and Experimental Research 24: 82A.

167. Bell, R.L., Stewart, R.B., Woods, J.E., Lumeng, L., Li, T.-K., Murphy, J.M., and McBride, W.J. (2000) Alcohol-preferring (P) and -nonpreferring (NP) rats differ in motor impairment after moderate doses of alcohol. Alcoholism: Clinical and Experimental Research 24: 88A

James M. Murphy 31 168. Bell, R.L., Rodd-Henricks, Z.A., Kelly, K.R., Webster, A.A., Lumeng, L., Li, T.-K., McBride, W.J.,

and Murphy, J.M. (2000) Alcohol drinking stimulates heart rate in alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental Research 24: 49A.

169. Engleman, E.A., McBride, W.J., Lumeng, L., Li, T.-K., and Murphy, J.M. (2000) Ethanol drinking experience attentuates (-)sulpiride-induced increases in extracellular dopamine (DA) levels in nucleus accumbens (NAc) of alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental Research 24: 85A

170. Jones, A.E., Bell, R.L., Crile, R.S., McKinzie, D.L., Murphy, J.M., Lumeng, L., Li, T.-K., and McBride, W.M. (2000) Effects of ethanol on startle responding and prepulse inhibition in adolescent high alcohol drinking (HAD) and low alcohol drinking (LAD) rats. Alcoholism: Clinical and Experimental Research 24: 94A.

171. Melendez, R.I., Engleman, E., Bell, R.L., Schmitz, C., McBride, W.J., Li, T.-K., and Murphy, J.M. (2000) Behavioral activity of alcohol-preferring (P) rats during anticipation and operant responding for oral reinforcers. Alcoholism: Clinical and Experimental Research 24: 51A

172. Nowak, K.L., Sajdyk, T.J., Ingraham, C.M., McBride, W.J., Lumeng, L., Li, T.-K., and Murphy, J.M. (2000) Alcohol intake of the alcohol-preferring P rat is decreased by microinjections of neuropeptide Y into the basolateral amygdala. Alcoholism: Clinical and Experimental Research 24: 82A.

173. Nowak, K.L., Thielen, R.J., Ingraham, C.M., McBride, W.J., Lumeng, L., Li, T.-K., and Murphy, J.M. (2000) Microinjections of 8-OH-DPAT into the dorsal raphe increase alcohol intake of the alcohol-nonpreferring NP rat. Alcoholism: Clinical and Experimental Research 24: 86A.

174. Powrozek, T.A., Badia-Elder, N.E., Murphy, J.M., and Stewart, R.B. (2000) Negative contrast effect in rats following a shift from a high to a low ethanol concentration. Alcoholism: Clinical and Experimental Research 24: 53A.

175. Rodd-Henricks, Z.A., Bell, R.L., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (2000) Repeated deprivations enhance the reinforcing properties of ethanol in alcohol preferring (P) rats. Alcoholism: Clinical and Experimental Research 24: S17:5

176. Rodd-Henricks, Z.A., Jones, A.R., Webster, A.A., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (2000) Repeated deprivations shift preference for higher ethanol concentrations and enhance the magnitude and duration of the alcohol deprivation effect in the alcohol preferring (P) rat. Alcoholism: Clinical and Experimental Research 24: 14A.

177. Rodd-Henricks, Z.A., Bell, R.L., Webster, A.A., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (2000) Low-dose ethanol stimulates locomotor activity in alcohol preferring adolescent rats. Alcoholism: Clinical and Experimental Research 24: 57A

178. Rodd-Henricks, Z.A., Bell, R.L., Melendez, R.I., Jones, A.R., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (2000) Repeated deprivations enhance operant alcohol self-administration in the alcohol preferring (P) rat. Alcoholism: Clinical and Experimental Research 24: 52A.

179. Smith, D.G., Learn, J.E., McBride, W.J., Lumeng, L., Li, T.-K., and Murphy, J.M. (2000) Changes in local cerebral glucose utilization following alcohol-relapse drinking in alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental Research 24: 53A.

180. Stewart, R.B., Roy, K.F., Badia-Elder, N.E., Li, T.-K., and Murphy, J.M. (2000) Sucrose intake following chronic oral ethanol self-administration in high alcohol drinking HAD rats. Alcoholism: Clinical and Experimental Research 24: 53A.

181. Stewart, R.B., Woods, J.E., II, Lumeng, L., Murphy, J.M., and Li, T.-K. (2000) Tolerance to the motor-impairing effects of ethanol: Comparison of replicate lines of high alcohol drinking (HAD) and low alcohol drinking (LAD) rats. Alcoholism: Clinical and Experimental Research 24: 89A.

182. Thielen, R.J., Nowak, K.L., Ingraham, C.M., Bell, R.L., McBride, W.J., Murphy, J.M., Lumeng, L., and Li, T.-K. (2000) Assessment of postsynaptic 5-HT1A receptor function in wistar, P and NP rats using 8-OH-DPAT-induced hypothermia. Alcoholism: Clinical and Experimental Research 24: 94A.

183. Stewart, R., Bell, R., Murphy, J., McBride, W., Lumeng L., and Li, T.-K. Ethanol tolerance in lines of rats selectively bred for oral ethanol preference. Presented at the 10th Congress of the International Society for Biomedical Research on Alcoholism, Yokohama, Japan, July2-8, 2000.

184. Rodd-Henricks, Z.A., Bell, R.L., Murphy, J.M. and McBride, W.J. (2000) Intracranial self-administration of cocaine into the posterior ventral tegmental area of rats. Society for Neuroscience Abstracts 26: 1833.

185. Bell, R.L., Rodd-Henricks, Z.A., Webster, A.A., Lumeng, L., Li, T.-K., McBride, W.J., and Murphy, J.M. (2000) Alcohol drinking alters activity in alcohol-preferring rats. Society for Neuroscience Abstracts 26: 1818.

James M. Murphy 32 186. Engleman, E.A., McBride, W.J., Li, T.-K., Lumeng, L., and Murphy, J.M. (2000) Microinjection of

ethanol (EtOH) into the ventral tegmental area (VTA) produces conditioned place aversion in alcohol-preferring rats. Society for Neuroscience Abstracts 26: 1818.

187. Melendez, R.I., Engleman, E., Schmitz, C., McBride, W.J., Li, T.-K., and Murphy, J.M. (2000) Extracellular levels of dopamine (DA) in the nucleus accumbens of alcohol-preferring rats during anticipation and operant responding for oral reinforcers. Society for Neuroscience Abstracts 26: 1818.

188. Badia-Elder, N.E., Stewart, R.B., Roy, K.F., Kennedy, M.J., Murphy, J.M., and Li, T.-K. (2001) Effects of microinfusions of neuropeptide Y (NPY) into the central nucleus of the amygdala (CeA) on ethanol intake in high alcohol drinking HAD1 rats. Alcoholism: Clinical and Experimental Research 25: 15A.

189. Badia-Elder, N.E., Stewart, R.B., Roy, K.F., Kennedy, M.J., Murphy, J.M., and Li, T.-K. (2001) Effects of neuropeptide Y (NPY) on ethanol-induced sleep time in alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental Research 25: 15A.

190. Bell, R.L., Rodd-Henricks, Z.A., Kuc, K.A., Lumeng, L., Li, T.-K., Murphy, J.M., and McBride, W.J. (2001) Alcohol consumption during periadolescence in alcohol-preferring (P) rats using a single or multiple concentrations of ethanol. Alcoholism: Clinical and Experimental Research 25: 20A

191. Bell, R.L., Rodd-Henricks, Z.A., Hsu, K.A., Lumeng, L., Li, T.-K., Murphy, J.M., and McBride, W.J. (2001) Alcohol consumption during periadolescence in high alcohol drinking (HAD) rats using a single or multiple concentrations of ethanol. Alcoholism: Clinical and Experimental Research 25: 20A

192. Rodd-Henricks, Z.A., Bell, R.L., Kuc, K.A., Melendez, R.I., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (2001) Access to multiple ethanol concentrations by high alcohol-drinking (HAD) rats contribute to the expression of a robust alcohol deprivation effect (ADE) which is enhanced with repeated deprivations. Alcoholism: Clinical and Experimental Research 25: 20A

193. Melendez, R.I., Rodd-Henricks, Z.A., Kuc, K.A., McBride, W.J., and Murphy, J.M. (2001) Regulation of ethanol reinforcement in the posterior ventral tegmental area by dopamine neurons. Alcoholism: Clinical and Experimental Research 25: 60A

194. Roy, K.F., Kennedy, M.J. Badia-Elder, N.E., Murphy, J.M., Neal-Beliveau, B., and Stewart, R.B. (2001) Effects of chronic amphetamine on motor activity and responding maintained by oral ethanol in rats. Alcoholism: Clinical and Experimental Research 25: 62A.

195. Bell, R.L., Rodd-Henricks, Z.A., Kuc, K.A., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (2001) Effects of periadolescent ethanol drinking on oral ethanol self-administration by adult alcohol-preferring (P) rats. I. Acquisition and extinction. Alcoholism: Clinical and Experimental Research 25: 63A

196. Rodd-Henricks, Z.A., Bell, R.L., Kuc, K.A., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (2001) Effects of periadolescent ethanol drinking on oral ethanol self-administration by adult alcohol-preferring (P) rats. II. Spontaneous recovery. Alcoholism: Clinical and Experimental Research 25: 63A

197. Engleman, E.A., Bell, R.L., Rodd-Henricks, Z.A., Ingraham, C.M., McBride, W.J., Li, T.-K., Lumeng, L., and Murphy, J.M. (2001) Conditioned place preference with morphine in alcohol-preferring (P) and Wistar rats. Alcoholism: Clinical and Experimental Research 25: 64A

198. Bell, R.L., Rodd-Henricks, Z.A., Hsu, C.C., Lumeng, L., Li, T.-K., Murphy, J.M., and McBride, W.J. (2001) Effects of amphetamine on the acoustic startle response of alcohol-preferring (P) and -nonpreferring (NP) rats. Society for Neuroscience Abstracts 27, Program no. 444.11.

199. Engleman, E.A., Thielen, R.J., O’Brien, C.E., Jones, A.R., McBride, W.J.,Lumeng, L., Li, T.-K., and Murphy, J.M. (2001) Effects of ethanol drinking experience on dopamine D2 autoreceptor function in the nucleus accumbens of alcohol-preferring (P) rats. Society for Neuroscience Abstracts 27, Program no. 981.8.

200. Melendez, R.I., Rodd-Henricks, Z.A., Zhang, Y., McBride, W.J., and Murphy, J.M. (2001) Systemic ethanol injection increases extracellular dopamine in the ventral pallidum but not globus pallidus. Society for Neuroscience Abstracts 27, Program no. 540.6.

201. Rodd-Henricks, Z.A., Bell, R.L., Melendez, R.I., Kuc, K.A., Murphy, J.M., McBride, W.J. (2001) Interaction between the reinforcing effects of cocaine and ethanol in the posterior ventral tegmental area of rats. Society for Neuroscience Abstracts 27, Program no. 981.16.

James M. Murphy 33 202. Smith, D.G., Learn, J.E., McBride, W.J., Li, T.-K., Lumeng, L., and Murphy, J.M. (2001) Effects of

relapse drinking on CNS functional activity of alcohol-preferring (P) rats. Society for Neuroscience Abstracts 27, Program no. 444.8

203. Engleman, E.A., Bell, R.L., Rodd-Henricks, Z.A., Ingraham, C.A., McBride, W.J., Li, T.-K., Lumeng, L., and Murphy, J.M. (2002) Consummatory and naltrexone-induced withdrawal behaviors after chronic morphine in P and NP rats. Alcoholism: Clinical and Experimental Research 26: 21A

204. Bell, R.L., Rodd-Henricks, Z.A., Kuc, K.A., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K., (2002) Binge drinking induces excessive alcohol intake in the alcohol-preferring P rat. Alcoholism: Clinical and Experimental Research 26: 61A

205. Bell, R.L., Rodd-Henricks, Z.A., Hsu, C.C., Murphy, J.M., Lumeng, L., Li, T.-K., and McBride, W.J. (2002) Expression of an alcohol deprivation effect by alcohol non-preferring (NP) rats given concurrent access to multiple concentrations of ethanol. Alcoholism: Clinical and Experimental Research 26: 61A

206. Rodd-Henricks, Z.A., Fontinella, C.V., Bell, R.L., Kuc, K.A., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (2002) Effects of concurrent access to and deprivation of ethanol and saccharin on the expression of a deprivation effect in alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental Research 26: 61A

207. Rodd-Henricks, Z.A., Bell, R.L., Kuc, K.A., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (2002) Effects of ethanol drinking during adulthood on operant ethanol self-administration in alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental Research 26: 62A

208. Rodd-Henricks, Z.A., Bell, R.L., Kuc, K.A., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (2002) A robust alcohol deprivation effect is expressed by alcohol preferring (P) rats following a brief initial exposure period. Alcoholism: Clinical and Experimental Research 26: 62A

209. Rodd-Henricks, Z.A., Sable, H.J.K., Bell, R.L., Kuc, K.A., Murphy, J.M., McBride, W.J., Lumeng, L., and Li, T.-K. (2002) Repeated alcohol deprivations retard extinction responding and enhance Pavlovian spontaneous responding by alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental Research 26: 62A

210. Elder, R.L., Stewart, R.B., Carroll, M.R., Badia-Elder, N.E., and Murphy, J.M. (2002) Differences to response in restraint stress in high alcohol drinking (HAD1) and low alcohol drinking (LAD1) rats in an elevated plus maze test of anxiety. Alcoholism: Clinical and Experimental Research 26: 97A

211. Stewart, R.B., Badia-Elder, N.E., Elder, R.L., Murphy, J.M., Lumeng, L., and Li, T.-K. (2002) Acute tolerance to the motor-impairing effects of ethanol in selectively-bred replicate high alcohol drinking (HAD1, HAD2) and low alcohol drinking (LAD1, LAD2) lines. Alcoholism: Clinical and Experimental Research 26: 97A

212. Badia-Elder, N.E., Stewart, R.B., Gilpin, N.W., Elder, R.L., Murphy, J.M., and Li, T.-K. (2002) Effects of neuropeptide Y (NPY) on ethanol-induced sleep time in alcohol-preferring (P) and –nonpreferring (NP) rats. Alcoholism: Clinical and Experimental Research 26: 99A

213. Melendez, R.I., Rodd-Henricks, Z.A., Pommer, T., Li, T.-K., McBride, W.J., and Murphy, J.M. (2002) Effects of dopamine D2 receptor inhibition in the ventral pallidum of the alcohol-preferring (P) rat on ethanol intake and extracellular levels of dopamine. Alcoholism: Clinical and Experimental Research 26: 111A

214. Rodd-Henricks, Z.A., Melendez, R.I., Kuc, K.A., Bell, R.L., McBride, W.J., Li, T.-K. and Murphy, J.M., (2002) Inhibition of 5-HT3 receptors within the posterior VTA retards the acquisition of operant self-administration of ethanol by alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental Research 26: 112A

215. Melendez, R.I., Rodd-Henricks, Z.A., Li, T.-K. McBride, W.J., and Murphy J.M. Dopamine efflux in the ventral pallidum of alcohol- preferring (P) rats during anticipation and operant self –administration of ethanol Program No. 289.10. 2002 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2002.

216. Engleman, E.A., Thielen, R.J., O'Brien, C.E., Hill, T.E., Lumeng, L.,.Li, T.-K, McBride, W.J., and Murphy, J.M.. Chronic ethanol drinking and prolonged or repeated deprivations reduce dopamine (DA) transmission in the nucleus accumbens (ACB) Program No. 309.1. 2002 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2002.

217. Sable, H.J.K., Rodd-Henricks, Z.A.,.Bell, R.L, Zhang, Y.,.Lumeng, L, McBride, W.J., Li, T.-K., and Murphy, J.M.. Intracranial self-administration of ethanol into the nucleus accumbens shell by alcohol preferring (P) rats. Program No. 309.6. 2002 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2002.

James M. Murphy 34 218. Bell, R.L., Rodd-Henricks, Z.A., Hsu, C.C., Lumeng L., Li, T.-K., Murphy, J.M., and McBride, W.J.

Acoustic startle response after long-term consumption of ethanol in alcohol-nonpreferring (NP) rats. Program No. 783.3. 2002 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2002.

219. Bell, R.L., Rodd-Henricks, Z.A., Boutwell, C.L., Hsu, C.C., Chernet, K.R., Murphy, J.M., Lumeng L., Li, T.-K., and McBride, W.J.. Effects of repeated deprivations on ethanol drinking by adolescent and adult alcohol-preferring P and –nonpreferring NP rats. International Society for Developmental Psychobiology, Orlando FL 2002.

220. Bell, R.L., Rodd, Z.A., Boutwell, C.L., Murphy, J.M., Lumeng L., Li, T.-K., and McBride, W.J. (2003) Expression of an alcohol deprivation effect (ADE) by low alcohol drinking (LAD) rats given concurrent access to multiple concentrations of alcohol. Alcoholism: Clinical and Experimental Research 27: 16A.

221. Bell, R.L., Rodd, Z.A., Schultz, J.A., Murphy, J.M., Lumeng L., Li, T.-K., and McBride, W.J. (2003) Expression of an alcohol deprivation effect by high alcohol drinking (HAD) rats given binge-like access to multiple concentrations of alcohol. Alcoholism: Clinical and Experimental Research 27: 16A.

222. Bell, R.L., Rodd, Z.A., Murphy, J.M., and McBride, W.J. (2003) Environmental modulation of genetically-predisposed ethanol consumption in rats. Alcoholism: Clinical and Experimental Research 27: 16A.

223. Bell, R.L., Rodd, Z.A., Hsu.C.C., Murphy, J.M., Lumeng L., Li, T.-K., and McBride, W.J. (2003) Expression of an alcohol deprivation effect by alcohol nonpreferring (NP) rats given access to a single concentration of ethanol. Alcoholism: Clinical and Experimental Research 27: 16A.

224. Bell, R.L., Rodd, Z.A., Schultz, J.A., Murphy, J.M., Lumeng L., Li, T.-K., and McBride, W.J. (2003) Naltrexone disrupts acauisition of ethanol intake in female peri-adolescent alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental Research 27: 17A.

225. Pommer, T.J., Rodd, Z.A., Bell, R.L., McQueen, V.K., Toalston, J.E., Engleman, E.A., Lumeng L., McBride, W.J., Li, T.-K., and Murphy, J.M. (2003) Effects of 5-HT3 antagonists within the nucleus accumbens shell on operant self-administration of ethanol by inbred alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental Research 27: 61A.

226. Rodd, Z.A., Bell, R.L., Pommer, T.J., McQueen, V.K., Li, T.-K., Lumeng L., McBride, W.J., and Murphy, J.M. (2003) Effects of 5-HT3 antagonists within the posterior VTA on operant self-administration of ethanol by alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental Research 27: 61A.

227. Engleman, E.A., Ingraham, C.M., O’Brien, C.E., McBride, W.J., and Murphy, J.M. (2003) Systemic ethanol administration fails to alter extracellular dopamine levels in the medial prefrontal cortex. Alcoholism: Clinical and Experimental Research 27: 92A.

228. Toalston, J.E., Rodd, Z.A., Melendez, R.I., Engleman, E.A., Lumeng L., McBride, W.J., and Murphy, J.M. (2003) Local perfusion of the D1 anatgonist (SCH-23390) increases extracellular dopamine (DA) levels in the ventral pallidum (VP) of Wistar and alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental Research 27: 92A.

229. Welchel, S.A., Kho, Y., Elder, R.L., Gilpin, N.W., Stewart, R.B., Murphy, J.M., Li, T.-K., and Badia-Elder, N.E. (2003) Neuropeptide Y and ethanol produce an additive suppression of motor activity in alcohol-preferring (P) and non-alcohol-preferring (NP) rats. Alcoholism: Clinical and Experimental Research 27: 126A.

230. Gilpin, N.W., Stewart, R.B., Murphy, J.M., Li, T.-K., and Badia-Elder, N.E. (2003) Effects of microinfusions of neuropeptide Y into the central nucleus of the amygdala (CeA) on ethanol intake in high alcohol drinking (HAD1) and low alcohol drinking (LAD1) rats. Alcoholism: Clinical and Experimental Research 27: 126A.

231. Gilpin, N.W., Stewart, R.B., Welchel, S.A., Murphy, J.M., Li, T.-K., and Badia-Elder, N.E. (2003) The effects neuropeptide Y on oral ethanol intake in high alcohol drinking (HAD1) rats following multiple periods of imposed ethanol abstinence. Alcoholism: Clinical and Experimental Research 27: 127A.

232. Gilpin, N.W., Stewart, R.B., Murphy, J.M., Li, T.-K., and Badia-Elder, N.E. (2003) Neuropeptide Y reduces oral ethanol intake in alcohol-preferring (P) rats following a period of imposed ethanol abstinence. Alcoholism: Clinical and Experimental Research 27: 127A.

James M. Murphy 35 233. Rodd, Z.A., Bell, R.L., McQueen, V.K., Pommer, T.J., Lumeng L., Li, T.-K., Murphy, J.M., and

McBride, W.J. (2003) 5-HT3 receptors in the ventral tegmental area regulate alcohol drinking and the reinforcing effects of alcohol. Alcoholism: Clinical and Experimental Research 27: 167A.

234. Rodd, Z.A., Bell, R.L., Sable, H.J., Pommer, T.J., McQueen, V.K., Lumeng, L.,.Murphy, J.M., and McBride, W.J. Naltrexone reduces two measures of alcohol craving in inbred alcohol - preferring (iP) rats. Program No 665.11. 2003 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2003.

235. Engleman, E.A., Ingraham, C.M., O'Brien, C.E., McBride, W.J., and Murphy, J.M. Effect of housing conditions on sulpiride - induced increases in extracellular dopamine levels in the nucleus accumbens of alcohol - preferring ( P ) rats. Program No 793.11. 2003 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2003.

236. Bell, R.L., Rodd, Z.A., Boutwel, C.L., Hsu, C.C., Lumeng, L., Li, T.-K., Murphy, J.M. and McBride, W.J. Acoustic startle response (ASR) and prepulse inhibition (PPI) after long-term consumption of ethanol in low alcohol-drinking (LAD) rats. Program No 853.10. 2003 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2003.

237. Engleman, E.A., Ingraham, C.M., McBride, W.J., and Murphy, J.M. (2004) Extracellular dopamine levels are lower in the medial prefrontal cortex alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental Research 28: 11A.

238. Carroll, M.E., Engleman, E.A., Murphy, J.M., and Simon, J.R. (2004) Dopamine and serotonin uptake in the nucleus accumbens, striatum and hippocampus of naive high alcohol drinking (HAD-2) and low alcohol drinking (LAD-2) rats. Alcoholism: Clinical and Experimental Research 28: 11A.

239. Pommer, T.J., Rodd, Z.A., Bell, R.L., McQueen, V.K., Kostrzewa, A.L., Lumeng, L., McBride, W.J., and Murphy, J.M. (2004) The ventral tegmental area and nucleus accumbens express regional heterogeneity to the effects of 5-HT3 antagonists on operant ethanol self-administration in alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental Research 28: 12A.

240. Rodd, Z.A., Bell, R.L., Zhang, Y., Gryszowka, V.E., Lumeng, L., Murphy, J.M. and McBride, W.J. (2004) Stimulating 5-HT3 receptors in the posterior ventral tegmental area (VTA) of alcohol preferring (P) rats is reinforcing. Alcoholism: Clinical and Experimental Research 28: 12A.

241. Gilpin, N.W., Stewart, R.B., Murphy, J.M., and Badia-Elder, N.E. (2004) Dose-dependent effects of neuropeptide Y (NPY) on ethanol intake in alcohol-preferring (P) rats following multiple periods of imposed ethanol abstinence. Alcoholism: Clinical and Experimental Research 28: 54A.

242. Gilpin, N.W., Stewart, R.B., Murphy, J.M., and Badia-Elder, N.E. (2004) Decreased autonomic and behavioral sensitivity to naloxone during long-term abstinence following chronic daily ethanol and withdrawal. Alcoholism: Clinical and Experimental Research 28: 55A.

243. Stewart, R.B., Badia-Elder, N.E., Stogsdill, T.R., Loholdt, J.M., Smith, R.J., Murphy, J.M. and Lumeng, L. (2004) Behavioral phenotyping of inbred alcohol preferring and nonpreferring (IP, INP) rat strains. Alcoholism: Clinical and Experimental Research 28: 89A.

244. Stewart, R.B., Elder, R.L., Badia-Elder, N.E., Smith, R.J., Murphy, J.M. and Gilpin, N.W. (2004) Scheduled-induced ethanol drinking in alchol-preferring and –nonpreferring (P,NP) and replicate high and low drinking (HAD1/LAD1, HAD2/LAD2) lines of rats. Alcoholism: Clinical and Experimental Research 28: 89A.

245. Rodd, Z.A., Bell, R.L., Strother, W.N., Sable, H.J.K., Aloor, H., McClintick, J.N., Stephens, M., Jerome, R., Liu, W.M., Lumeng, L., Murphy, J.M., Edenberg, H.J. and McBride, W.J. (2004) Self-infusion of ethanol into the posterior ventral tegmental area (VTA) alters gene expression in VTA projection areas. Alcoholism: Clinical and Experimental Research 28: 89A

246. Bell, R.L., Rodd, Z.A., Schultz, J.A., Hsu, C.C., Lumeng, L., Li, T.-K., Murphy, J.M. and McBride, W.J. (2004) Pattern of ethanol drinking by peri-adolescent alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental Research 28: 95A.

247. Sable, H.J.K., Bell, R.L., Rodd, Z.A., Schultz, J.A., Murphy, J.M. and McBride, W.J. (2004) Effects of naltrexone on the acquisition of ethanol intake in adolescent and adult alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental Research 28: 95A.

248. Rodd, Z.A., Bell, R.L., Kuc, K.A., Gryszowka, V.E., Lumeng, L., Murphy, J.M. and McBride, W.J. (2004) Alcohol-preferring (P) rats are more sensitive than Wistar rats to the reinforcing effects of cocaine in the nucleus accumbens shell. Alcoholism: Clinical and Experimental Research 28: 97A.

249. Bell, R.L., Rodd, Z.A., Boutwell, C.L., Lumeng, L., Li, T.-K., McBride, W.J. and Murphy, J.M. (2004) A conditioned heart rate response during deprivation in ethanol-experienced alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental Research 28: 98A.

James M. Murphy 36 250. Bell, R.L., Rodd, Z.A., Boutwell, C.L., Stewart, R.B., Badia-Elder, N.E., Murphy, J.M. and McBride,

W.J. (2004) Ethanol odor alters prepulse inhibition, but not acoustic startle responding, in ethanol-experience adult P rats. Alcoholism: Clinical and Experimental Research 28: 98A.

251. Rodd, Z.A., McKinzie, D.L., Bell, R.L., Sable, H.J.K., Lumeng, L., Murphy, J.M., Schoepp, D.D. and McBride, W.J. (2004) LY404039, a metabotropic glutamate 2/3 agonist, reduces alcohol craving in alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental Research 28:134A.

252. Bell, R.L., Rodd, Z.A., Boutwell, C.L., Murphy, J.M. Lumeng, L., Li, T.-K. and McBride, W.J. (2004) Repeated daily scheduled access results in binge-like ethanol consumption in adult inbred P rats. Alcoholism: Clinical and Experimental Research 28: 143A.

253. Bell, R.L., Rodd, Z.A., Sahr, A.E., Murphy, J.M. and McBride, W.J. (2004) Ethanol consumption during adolescence and its long-term consequences. Alcoholism: Clinical and Experimental Research 28: 175A.

254. Rodd, Z.A., Bell, R.L., Lumeng, L., Li, T.-K., Murphy, J.M., Edenberg, H.J. and McBride, W.J. (2004) Gene expression in limbic regions following ethanol eslf-infusion into the posterior ventral tegmental area (VTA). Alcoholism: Clinical and Experimental Research 28: 183A.

255. Oster S.M., Thielen R.J.,.Engleman E.A, Ingraham C.M.,.Moran A.D, Marunde R.L., Lumeng L.,.Murphy J.M, McBride W.J. Effects of amount of ethanol drinking on extracellular levels of serotonin in the nucleus accumbens of P rats. Program No 117.12. 2004 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2004.

256. Kostrzewa A.L., Rodd Z.A., Bell R.L., Murphy J.M., McBride W.J. Nicotine is self-administered into the posterior ventral tegmental area of Wistar rats. Program No 121.10. 2004 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2004.

257. Rodd Z.A,.Bell R.L, McQueen V.K., Davids M.R., Hsu C.C., Lumeng L., Murphy J.M., McBride W.J. Exposure to repeated deprivation cycles results in prolonged alterations in the sensitivity to the reinforcing effects of alcohol within the posterior VTA in alcohol-preferring (P) rats. Program No 489.1. 2004 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2004.

258. Bell R.L, Rodd Z.A., Sable H.J.K., McQueen V.K., Davids M.R., Murphy J.M., Lumeng L., McBride W.J. Cannabinoid CB1 antagonist reduces alcohol intake during acquisition, maintenance, and relapse in inbred alcohol preferring (IP) rats. Program No 489.6. 2004 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2004.

259. Gryszowka V.E., Rodd Z.A., Bell R.L., Lumeng L., Murphy J.M., McBride W.J. The reinforcing properties of 5-HT3 receptors in the ventral tegmental area (VTA): Evidence for regional heterogeneity and genetic influence. Program No 580.6. 2004 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2004.

260. Oster SM, Rodd ZA, McQueen VK, Bell RL, Lumeng L, McBride WJ, Murphy JM. The CB1 agonist, CP 55,940, increased ethanol consumption during acquisition in high alcohol-drinking (HAD-2) rats. Alcoholism: Clinical and Experimental Research 29: 12A, 2005

261. Toalston JE, Rodd ZA, Davids MR, Bell RL, Engleman EA, Murphy JM, McBride WJ. Microinjections of ethanol into the posterior, but not anterior, ventral tegmental area (VTA) increase dopamine release in the nucleus accumbens. Alcoholism: Clinical and Experimental Research 29: 13A, 2005.

262. Rodd ZA, McKinzie DL, Bell RL, Pommer TJ, Lumeng L, Murphy JM, Schoepp DD, McBride WJ. LY255582 reduces alcohol seeking, relapse drinking, and maintenance drinking in alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental Research 29: 18A, 2005.

263. Rodd ZA, Bell RL, Pommer TJ, McQueen VK, Lumeng L, Murphy JM, McKinzie DL, McBride WJ. The CB1 antagonist SR141716 transiently reduces operant ethanol self-administration during relapse drinking and maintenance, and inhibits alcohol seeking alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental Research 29: 19A, 2005.

264. Bell RL, Rodd ZA, Schultz JA, Troy KM, Lumeng L, Murphy JM, McBride WJ. Pattern of ethanol drinking by adolescent and adult high alcohol drinking (HAD-2) rats. Alcoholism: Clinical and Experimental Research 29: 19A, 2005.

265. Franklin KM, Engleman EA, Ingraham CM, McBride WJ, Murphy JM. Effects of single and repeated ethanol injections on D2 autoreceptor function in the nucleus accumbens (NACC) of Wistar rats. Alcoholism: Clinical and Experimental Research 29: 93A, 2005.

James M. Murphy 37 266. Bell RL, Rodd ZA, Sable HJK, McKinzie DL, McQueen VK, Schultz JA, Murphy JM, Lumeng L,

McBride WJ. Assessing the role of the opioid system as a pharmacotherapeutic target in the treatment of alcoholism: Old and new. Alcoholism: Clinical and Experimental Research 29: 187A, 2005.

267. McKinzie DL, Rodd ZA, Bell RL, Murphy JM, Schoepp DD, McBride WJ. Promising novel pharmacotherapeutics in the treatment of alcoholism: What’s around the corner? Alcoholism: Clinical and Experimental Research 29: 188A, 2005.

268. Oster SM, Rodd Z.A, Toalston JE, Murphy JM, Bell RL, McBride WJ. Ethanol self -administration into the posterior ventral tegmental area is not mediated by GABAA receptors. Program Number: 680.20, 2006 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience.

269. Toalston JE, Rodd Z.A, Oster SM, Murphy JM, Bell RL, McBride WJ. Activating serotonin -3 receptors in the posterior ventral tegmental area is reinforcing and requires stimulation of dopamine neurons. Program Number: 227.12, 2006 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience.

270. Rodd ZA, Toalston JE, Davids MR, Bell RL, Engleman, EA, Murphy JM, and McBride WJ. Microinjections of acetaldehyde into the posterior ventral tegmental area (VTA) increases dopamine release in the nucleus accumbens. Alcoholism: Clinical and Experimental Research 30: 132A, 2006.

271. Rodd ZA, Toalston JE, Davids MR, Bell RL, Engleman, EA, Murphy JM, and McBride WJ. Chronic alcohol drinking alters the sensitivity of dopamine (DA) neurons in the posterior ventral tegmental area (VTA) to the local activating effects of ethanol. Alcoholism: Clinical and Experimental Research 30: 133A, 2006.

272. Carroll MR, Rodd ZA, McBride WJ, Murphy JM, and Simon JR. Chronic EtOH consumption increases DA uptake in the ACb of female HAD-1 rats. Alcoholism: Clinical and Experimental Research 30: 181A, 2006.

273. Toalston JE, Rodd Z.A, Oster SM, Murphy JM, Bell RL, McBride WJ. Effects of peri-adolescent ethanol drinking on oral saccharin self-administration by adult alcohol preferring (P) rats. Alcoholism: Clinical and Experimental Research 30: 187A, 2006.

274. Engleman EA, Thielen RJ, Rodd ZA, Murphy JM and McBride WJ. Neurochemical measures of neuroadaptations of the ventral tegmental area – nucleus accumbens dopamine system after chronic alcohol drinking. Alcoholism: Clinical and Experimental Research 30: 246A, 2006.

275. Bell RL, Rodd ZA, Kimpel MW, Strother WN, Jerome R, McClintick JN, Murphy JM, Lumeng L, Edenberg HJ, McBride WJ. Repeated scheduled drinking-in-the-dark (DID) access to ethanol and its effects on gene expression in adult inbred P rats. Alcoholism: Clinical and Experimental Research 30: 265A, 2006.

276. Bell RL, Rodd ZA, Larson LA, Toalston JE, Cook JB, Oster SM, Lumeng L, McBride WJ, Murphy JM. Peri-adolescent ethanol exposure reduces basal heart rate but not autonomic reactivity to self-administered ethanol in adult P rats Alcoholism: Clinical and Experimental Research 31: 21A. Presented at the 30th annual meeting of the Research Society on Alcoholism, Chicago, IL July 7-11, 2007.

277. Bell RL, Rodd ZA, Schultz JA, Toalston JE, Oster SM, Murphy JM, Lumeng L, McBride WJ. An evaluation of the consummatory behavior of genetically selected alcohol-preferring rats during adolescence and adulthood. Alcoholism: Clinical and Experimental Research 31: 23A. Presented at the 30th annual meeting of the Research Society on Alcoholism, Chicago, IL July 7-11, 2007

278. Toalston JE, Rodd ZA, Oster SM, Murphy JM, Bell RL, McBride WJ. Effects of saccharin or ethanol drinking by alcohol-preferring (P) rats during peri-adolescence on EtOH self-administration during adulthood. Alcoholism: Clinical and Experimental Research 31: 73A. Presented at the 30th annual meeting of the Research Society on Alcoholism, Chicago, IL July 7-11, 2007

279. Oster SM, Pommer TJ, Toalston JE, Murphy JM, Bell RL, McBride WJ, Rodd ZA. Exposure to multiple concentrations of ethanol under operant oral self-administration conditions: Effects of repeated ethanol deprivations. Alcoholism: Clinical and Experimental Research 31: 74A. Presented at the 30th annual meeting of the Research Society on Alcoholism, Chicago, IL July 7-11, 2007

280. Pommer T J, Oster S M, Toalston JE, Murphy JM, Bell RL, McBride WJ, Rodd ZA. Introduction of a ‘lock-out’ during concurrent access to multiple ethanol concentrations: Effects of repeated deprivations Alcoholism: Clinical and Experimental Research 31: 74A. Presented at the 30th annual meeting of the Research Society on Alcoholism, Chicago, IL July 7-11, 2007

James M. Murphy 38 281. Franklin KM, Engleman EA, Ingraham CM, Sentir AM, McBride WJ, Murphy JM. Effects of single

and repeated systemic ethanol administration on dopamine D2 autoreceptor function in the nucleus accumbens of Wistar rats. Alcoholism: Clinical and Experimental Research 31: 84A. Presented at the 30th annual meeting of the Research Society on Alcoholism, Chicago, IL July 7-11, 2007

282. Engleman EA, Ingraham CM, Franklin KM, Keith CM, McClaren JA, Morzorati SL, O’Connor S, Thielen RJ, Murphy JM, McBride WJ. Measuring ethanol levels using subcutaneous microdialysis. Alcoholism: Clinical and Experimental Research 31: 177A. Presented at the 30th annual meeting of the Research Society on Alcoholism, Chicago, IL July 7-11, 2007

283. Toalston JE, Murphy JM, Bell RL, McBride WJ. ADOLESCENT CONSUMPTION OF Ethanol, but not saccharin, increases the reinforcing properties of ethanol in adulthood. Alcoholism: Clinical and Experimental Research 31: 307A. Presented at the 30th annual meeting of the Research Society on Alcoholism, Chicago, IL July 7-11, 2007

284. Engleman EA, Ingraham CM, Sentir AM, Franklin KM, McBride WJ, Murphy JM. Heterogenity of 5-HT3 effects in the shell and core subregions of the nucleus accumbens. Society for Neuroscience Abstracts 780.19/E40. Presented at the 37th annual meeting of the Society for Neuroscience, San Diego, CA, November 3-7, 2007

285. Franklin KM, Engleman EA, Ingraham CM, W. J. McBride WJ, Murphy JM. A single, moderate ethanol exposure increases extracellular dopamine levels and reduces extraction fractions in the nucleus accumbens of Wistar rats. Society for Neuroscience Abstracts 909.18/FF2. Presented at the 37th annual meeting of the Society for Neuroscience, San Diego, CA, November 3-7, 2007

286. Cook JB, Bracken AL, Rodd ZA, Toalston, JE, Lumeng L, Murphy JM, McBride WJ, Bell RL. The effects of ethanol consumption during peri-adolescence or adulthood on subsequent ethanol-induced motor impairment in alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental Research 32: 91A. Presented at the Joint Scientific Meeting of the Research Society on Alcoholism and the International Society for Biomedical Research on Alcoholism, June 27-July 2, 2008, Washington, D.C

287. Oster SM, Ding Z-M, Hauser SR, Pommer TJ, Bell RL, Murphy JM, McBride WJ, Rodd ZA. Microinjection of atrial naturietic peptide into the nucleus accumbens shell reduces ethanol self-administration in alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental Research 32: 166A. Presented at the Joint Scientific Meeting of the Research Society on Alcoholism and the International Society for Biomedical Research on Alcoholism, June 27-July 2, 2008, Washington, D.C

288. Oster SM, Z.M. Ding, Toalston, JE, Bell RL, Pommer TJ, Lumeng L, Murphy JM, Rodd ZA, WJ McBride. Alcohol drinking increases the sensitivity of the nucleus accumbens shell to the reinforcing effects of cocaine in alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental Research 32: 166A. Presented at the Joint Scientific Meeting of the Research Society on Alcoholism and the International Society for Biomedical Research on Alcoholism, June 27-July 2, 2008, Washington, D.C

289. Dhaher R, Rodd ZA, Whalen CP, Getachew B, Hauser S, McBride WJ, Murphy JM, Bell RL. Lesions of the amygdala, but not the nucleus accumbens, decrease the maintenance of ethanol self- administration in alcohol-prefering (P) rats. Alcoholism: Clinical and Experimental Research 32: 167A. Presented at the Joint Scientific Meeting of the Research Society on Alcoholism and the International Society for Biomedical Research on Alcoholism, June 27-July 2, 2008, Washington, D.C.

290. Franklin KM, Engleman EA, Blankenship RL, Ingraham CM, Murphy JM. Caffeine increases ethanol self-administration in alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental Research 33: 223A. Presented at the Annual Meeting of the Research Society on Alcoholism, June 20-24, 2009, San Diego, CA

291. Engleman EA, Ingraham CM, Franklin KM, Blankenship RL, McBride WJ, Murphy JM. Chronic ethanol (EtOH) drinking increased dopamine (DA) transmission in the ventral pallidum (VP) and the prefrontal cortex (PFC). Alcoholism: Clinical and Experimental Research 33: 80A. Presented at the Annual Meeting of the Research Society on Alcoholism, June 20-24, 2009, San Diego, CA

292. Toalston JE, Rodd ZA, Oster SM, Bell RL, Murphy JM, McBride WJ. Peri-adolescent ethanol drinking increases the sensitivity of the ventral tegmental area to the reinforcing effects of ethanol in adulthood. Alcoholism: Clinical and Experimental Research 33: 96A. Presented at the Annual Meeting of the Research Society on Alcoholism, June 20-24, 2009, San Diego, CA

James M. Murphy 39

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Murphy, James M. - CV · CURRICULUM VITAE James M. Murphy Associate Dean for Research and Graduate Education Dean’s Office, LD222 School of Science, IUPUI and Professor of Psychology