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Picture Credits: 1. http://www.antech.ie/microphazirnir.shtml; 2. http://www.mt.com; 3. http://www.malvern.com; 4. http://www.bruker.com/products/infrared-near- infrared-and-raman-spectroscopy/ft-nir/matrix-i/overview.html Process Analytical Technologies 1 2 3 4 Spray Drying Processes © 2014 Hovione Solution preparation Spray Drying Secondary Drying Raw material dispensing Process Mass Spectroscopy Process NIR Process Laser Diffraction Real-time particle size distribution 0 5 10 15 20 25 30 0 10 20 30 40 50 60 70 Handheld NIR Raw materials identification and qualification Exhaust gas analysis Exhaust gas analysis Drying end-point solid state characterization Process NIR Multivariate Analysis FBRM Agglomeration and suspension stability Process viscosimetry Process turbidimetry Dissolution end-point 1. 2. 3. 4. 4.

Multivariate Analysis 1 2 Raw material Solution - hovione.com · Raw material dispensing Process Mass ... size distribution 0 5 10 15 20 25 30 0 10 20 30 40 50 60 70 Handheld NIR

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Picture Credits: 1. http://www.antech.ie/microphazirnir.shtml; 2. http://www.mt.com; 3. http://www.malvern.com; 4. http://www.bruker.com/products/infrared-near-infrared-and-raman-spectroscopy/ft-nir/matrix-i/overview.html

Process Analytical Technologies

1 2

3

4

Spray Drying Processes

© 2014 Hovione

Solutionpreparation

SprayDrying

SecondaryDrying

Raw materialdispensing

Process MassSpectroscopy

Process NIR

Process Laser Di�raction

Real-time particlesize distribution

0

5

10

15

20

25

30

0 10 20 30 40 50 60 70

Handheld NIR

Raw materials identificationand qualification

-0 .4

-0 .3

-0 .2

-0 .1

0

0 .1

0 .2

0 .3

-0 .3 -0 .2 -0 .1 0 0 .1 0 .2

Exhaust gas analysis

Exhaust gas analysis

Drying end-point solid state

characterization

Process NIR

MultivariateAnalysis

FBRMAgglomeration andsuspension stability

Process viscosimetry

Process turbidimetryDissolution end-point

1.

2.

3.

4.

4.