Morton J. Kern MD, MSCAI, FACC, FAHAChief of Medicine, VA Long Beach HSC

Professor of MedicineUniversity California Irvine

Acute Coronary Syndromes

2015

58 yo Man, 58 yo Man, Chest pain Chest pain

after lunch on after lunch on the way to the way to

car.car.Bad sushi?Bad sushi?

CAD is a diffuse process with focal atherosclerotic material (plaque).

Some plaques are obstructive but not thrombotic.Others are potentially thrombotic but not obstructive.

Myocardial Infartion=Death of myocardial cells.

Clinical MI = symptoms, ECG and Biomarkers

Normal Atherosclerotic Plaque

CAD as a cause of Myocardial Ischemia and Infarction

Angiography vs. Pathology

179ACS

LAD

Angiography vs CTA for CAD

Motoyama et al. JACC 2007Motoyama et al. JACC 2007

Fibrous plaque

Positive remodelingSoft plaque

Natural History of CAD : A story of remodeling

•Acute Coronary Syndrome

•72 year-old Man

•Plaque crater, erosion

•Thrombus

•Calcific nodule

What are the Big 5 medications for CAD?

1.BB2.ASA/antiplatelet agents3.Statins4.Nitrates5.Antihypertensive and other risk factor medications

Braunwald’s Heart Disease, 7th Edition

Beta blockersCA blockersACEINTG

NTGASAHeparinGPB’s

Statins

Ranolazine

Perfusion

Abnormalities

Systolic Dysfunction

Δ ECG

Angina

Diastolic Dysfunction

Duration and severity of ischemia

Nuclear Imaging

Stress Echo/MRI

Stress ECG

Ischemic Cascade

EuroIntervention 2015;10:1024-1094  published online ahead of print September 2014

2014 ESC/EACTS Guidelines on myocardial revascularization

Who needs Stress Testing?

Spectrum of ACS Presentations

DefinitionIschemia without

necrosisNecrosis

(nontransmural)Transmural necrosis

DiagnosisNegative Biomarkers Positive biomarkers Positive biomarkers

No ECG ST-segment elevationECG ST-segment

elevation

Treatment Invasive or conservative depending on risk Immediate reperfusion

UA NSTEMI STEMI

Roger VL, Go AS, Lloyd-Jones DM, et al.. Circulation. 2011;123:e18-e209.

Heart Attack Warning Signs• Chest discomfort

– Pressure– Squeezing– Fullness – Pain

• Discomfort in other areas of the upper body– Arms– Jaw– Neck– Back– Stomach

• Shortness of Breath• Cold sweat, nausea or lightheadedness• **Women have atypical presentations!! Be more wary

Who Presents With Atypical Symptoms?

Antman EM, Anbe DT, Armstrong PW, et al. www.acc.org/clinical/guidelines/stemi/index.pdf. Updated 2004. Accessed June 20, 2007.

Key Features of an ECG

P-R T-P Interval

(continues to next heartbeat) T-P Interval

(continued from next heartbeat)

Marieb EN, Hoehn K. Human Anatomy and Physiology. 8th ed. San Francisco, CA: Pearson Benjamin Cummings; 2010.

Example of ST-segment Elevation (STEMI)

J point

STE

Example of ST-segment Depression (UA/STEMI)

J point

STD

Example of T-wave Inversion (UA/STEMI)

T wave changes

Normal 12-lead ECG

http://www.uptodate.com/contents/image?imageKey=CARD%2F1617. Accessed Aug 6. 2011.

INFERIOR

ANTERIORLATERAL

LATERAL

Early-Stage Acute MI (STEMI)

ST-segment elevation ST-segment depression

T-wave inversion

3-Day-Old MI (STEMI)

ST-segment elevation T-wave inversion

UA - NSTEMI

T-wave inversion

Early InvasiveEarly Invasive Initial Initial ConservativeConservative

Braunwald E et al. Available at: www.acc.org.Bowen WE, McKay RG. N Engl J Med. 2001;344:1939-1942.

* Also known as Q-wave MI* Also known as Q-wave MI†† Also known as non-Q-wave MIAlso known as non-Q-wave MI

Treatment of Acute Coronary SyndromeTreatment of Acute Coronary Syndrome

Thygesen K et al. Circulation 2007; available at: http://circ.ahajournals.org.

New clinical classification of MI

Classification Description

1 Spontaneous MI due to coronary event, i.e. plaque erosion and/or rupture, fissuring, or dissection

2 MI secondary to ischemia due to an imbalance of O2 supply and demand, as from coronary spasm or embolism, anemia, arrhythmias, hypertension, or hypotension

3 Sudden unexpected cardiac death, including cardiac arrest, with new ST-segment elevation; new LBBB; or pathologic or angiographic evidence of fresh coronary thrombus--in the absence of reliable biomarker findings

4a MI associated with PCI

4b MI associated with documented in-stent thrombosis

5 MI associated with CABG surgery

Thygesen, K. et al. Circulation 2007;116:2634-2653

Biomarkers of Myocardial Damage

Timing of Release of Various Biomarkers After Acute Myocardial Infarction

Shapiro BP, Jaffe AS. Cardiac biomarkers. In: Murphy JG, Lloyd MA, editors. Mayo Clinic Cardiology: Concise Textbook. 3rd ed.

Rochester, MN: Mayo Clinic Scientific Press and New York: Informa Healthcare USA, 2007:773–80.

Anderson JL, et al. J Am Coll Cardiol 2007;50:e1–e157, Figure 5.

Cardiac-specific troponins are optimum biomarkers (Level IC)

For STEMI, reperfusion therapy should be initiated as soon as

possible and is not contingent on a biomarker assay (Level IC)

Troponin Elevation and Likelihood for Mortality

Troponin Elevation and Likelihood for Mortality

Antman EMl. N Engl J Med. 1996; 335: 1342-1349.% mortality at 42 days

<0.4 <1.0 <2.0 <5.0 <9.0 9.0

2

4

6

8

0

Troponin levels

Non-MI Causes of Troponin Elevation

J Am Coll Cardiol. 2014;63(3):201-214

54 yo M w 2h severe substernal CP - ECG

Early InvasiveEarly Invasive Initial Initial ConservativeConservative

Braunwald E et al. Available at: www.acc.org.Bowen WE, McKay RG. N Engl J Med. 2001;344:1939-1942.

* Also known as Q-wave MI* Also known as Q-wave MI†† Also known as non-Q-wave MIAlso known as non-Q-wave MI

Treatment of Acute Coronary SyndromeTreatment of Acute Coronary Syndrome

Left Coronary System has mild CAD. RCA is 100%

Final post Stent

PCI vs Fibrinolysis in STEMI Systematic Overview

Short term (4-6 weeks)

Keeley EC et al. Lancet. 2003;361:13-20.

PP=0.0002=0.0002PP=0.0003=0.0003 PP<0.0001<0.0001

PP<0.0001<0.0001

PP=0.0004=0.0004

(23 RCTs, n=7,739)(23 RCTs, n=7,739)(23 RCTs, n=7,739)(23 RCTs, n=7,739)

8.5 7.3 7 .2

22.0

2.0

7.24.9

2.8

6.8

1.00.0

5.0

10.0

15.0

20.0

25.0

D eath D eathS H OC K

excl.

R e in farctio n R ecu rren tischem ia

S tro ke

Perc

ent (

%)

L ysisP C I

Medical Therapy for STEMI Managed Medical Therapy for STEMI Managed by Primary PCIby Primary PCI

ASA

Anticoagulant UFH (Bival)

P2Y12 inhibitor

Clopidogrel 600Prasugrel 60, or Ticagrelor 180

Beta Blocker IV prn Oral within 24h

GP IIb/IIIa

EptifibatideAbciximab

Statin

Presentation Access—Wire—Balloon

EDCCL

Importance of Rapid Reperfusion in STEMI

30-minute delay = 8% increase in 1-year mortality30-minute delay = 8% increase in 1-year mortality

Rathore SS, Curtis JP, Chen J, et al. BMJ. 2009;338:b1807.Antman E. ST-segment elevation myocardial infarction: Management. In: Bonow RO, Mann DL, Zipes P, et al, eds. Braunwald's Heart Disease. 9th ed. Philadelphia, PA: Elsevier Saunders; 2011a:1087-1110.

48 yo Man, 48 yo Man, Chest pain Chest pain after lunch after lunch

while walking while walking to car.to car.

48 yo M, HBP with Chest pain while walking

TIMI Risk Score (n=7)

Antman EM, Cohen M, Bernink PJ, et al. JAMA. 2000;284:835-842.

TIMI Study Group. TIMI Risk Score Calculator. http://www.timi.org/?page_id=294. Updated 2011. Accessed July 7, 2011.

What does TIMI RISK mean?

Increasing TIMI RISK 0/1 to 5/7 increases risk of death, MI, urgent revascularization within 14 days 5% to 41%.

Antman EM et al. TIMI 11B, JAMA 2000;284:835-842

Early InvasiveEarly Invasive Initial Initial ConservativeConservative

Braunwald E et al. Available at: www.acc.org.Bowen WE, McKay RG. N Engl J Med. 2001;344:1939-1942.

* Also known as Q-wave MI* Also known as Q-wave MI†† Also known as non-Q-wave MIAlso known as non-Q-wave MI

Treatment of Acute Coronary SyndromeTreatment of Acute Coronary Syndrome

STEMI?

Differential Dx for ACS Chest Pain Syndromes (beyond STEMI, NSTEMI, UA)

• Aortic dissection

• Pulmonary embolus

• Perforating ulcer

• Pericarditis

• GERD (Gastroesophageal reflux disease)

• Heart failure, Pneumonia, Pneumothorax