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More than an immune booster
Schedule
• Basics• Avemar and Immunovet• Production• Effects• Results
Introduction
• Albert Szent-Györgyi (Hungarian Nobel laureate)• Biochemical research with fermented wheat germ• Effective molecule complex against cancer cells• Development by Hungarian sciencists, inspired by
His legacy• Avemar available from 1998
• Raw materials• Manufacturing technology
• fermentation• extraction• standardization (2,6 dimethoxy-p-benzoquinone)
• Similarities• same manufacturing line• one fermentative mass
• Differences• different fractions of the fermented mass• different goal
Avemar and Immunovet – FWGE
AU
0,00
0,10
0,20
0,30
0,40
0,50
0,60
0,70
Minutes
2,00 4,00 6,00 8,00 10,00 12,00 14,00 16,00 18,00 20,00 22,00 24,00
1,903 2,070
2,224
2,618
2,801
2,991
3,253
3,448
3,692
3,979
4,323
4,860
5,180
5,762
6,262
6,947
7,2407,883
8,901
9,628
10,323
10,615
11,344
12,017
12,443
13,127 14,161
14,799
15,333 15,702
16,260
17,105
17,66418,087
18,854
19,371
20,151
21,092
21,445
22,262
• Raw materials• wheat germ• yeast
• Special fermentation process• Extraction of active compounds• Drying, concentration and
standardization• Tablet pressing and boxing
Immunovet
• Goal is the prevention of healthy status
• Healthy– Not equal to not sick
Fermented Wheat Germ Extract
• Pentose Phosphate Pathway (PPP)– Glucose Ribose5Phosphate mRNA DNA
replication– FWGE blocks Transketolase (Glucose
Ribose5Phosphate)– DNA replication stops, non-oxidative way
slows– Selective effect for cancer cells (why?)
FWGE – cell-level effects 1.
• Apoptosis induction– Poly-(ADP-Ribose)-Polimerase (PARP)
important in the repairing of DNA-chains– Extremely high activity in cancer cells– FWGE aktivates the proteolysis of PARP– A DNS-repairing impairs, thus DNA
chains fragment
FWGE – cell-level effects 2.
• FWGE block the synthesis of MHC-I molecules in cancer cells–Major histocompatibility complex (ID
card to present for Leukocytes)– No MHC1 not friendly– NK cells activate
FWGE – cell-level effects 3.
• ICAM-1 (intercellular adhesion molecule)– Stabilizes the cell-cell interaction,
facilitates the leucocyte entdothelial transmigration• Downregulated on surface of tumor vessels –
no help for leucocytic infiltration• FWGE upregulates ICAM-1 expression, making
leucocytic infiltration easier
FWGE – cell-level effects 4.
• COX 1 and 2 non selective inhibitor – immunmodulation, anti-inflammatory effect
FWGE – anti-inflammatory
Reconvalescence timeAfter bone surgeries
78%
19%
3%
Shortened
Not changed
No data
Clinical status in contagious diseases(used PARALLEL the veterinary treatment)
62%17%
18%
3%
Improved
Not changed
Worsened
No data
Clinical status in oncologic cases(used PARALLEL the veterinary treatment)
90%
4% 4% 2%
Improved
Not changed
Worsened
No data
• Available since 2002–Millions of animals, so far no adverse
effect
• Not toxic („like a slice of bread”)– LD50 > 2500mg/bwkg
Immunovet
Immunovet
• Easy to administer• Good taste, willing to eat
Immunovettablets
• Young animals – quick growth• Hair change• Stress• Chronic diseases• After surgeries• Elder animals – general boost
Immunovet
• With the recommendation of the Hungarian Veterinary Chamber
• With the recommendation of the Hungarian Kennel Club
Immunovet
Thank you for the attention!