Molecular Devices Complete Imaging Solutionmdc.custhelp.com/euf/assets/content/Molecular Devices Complete...environment of Molecular Devices complete imaging solution, which combines

Molecular Devices Complete Imaging Solution

IT Requirements to Set Up: MetaXpress® Software MetaXpress® PowerCore™ Software AcuityXpress™ Software MDCStore™ Data Management Solution

Revision K

August 2012

PAGE 2 OF 13 IT REQUIREMENTS TO SET UP: METAXPRESS SOFTWARE, METAXPRESS POWERCORE SOFTWARE, ACUITYXPRESS SOFTWARE,AND MDCSTORE DATA MANAGEMENT SOLUTION

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IT REQUIREMENTS TO SET UP: METAXPRESS SOFTWARE, METAXPRESS POWERCORE SOFTWARE, ACUITYXPRESS SOFTWARE,AND MDCSTORE DATA MANAGEMENT SOLUTION PAGE 3 OF 13

Contents

1.1. ABOUT THIS GUIDE ................................................................................ 3 1.2. DEFINITIONS ....................................................................................... 3 1.3. TYPICAL CONFIGURATIONS FOR MULTI‐USER ENVIRONMENTS ................................. 4 1.4. NOTE ON THE INSTALLATION PROCESS ........................................................... 5 1.5. REQUIREMENTS BEFORE THE ON‐SITE INSTALLATION OF MOLECULAR DEVICES

INSTRUMENTATION BY MOLECULAR DEVICES PERSONNEL ..................................... 6 1.6. DURING ON‐SITE INSTALLATION OF MOLECULAR DEVICES INSTRUMENTATION BY

MOLECULAR DEVICES PERSONNEL................................................................ 8 1.7. POST‐INSTALLATION REQUIREMENTS ............................................................ 9 1.8. Table 1: IT Network Ports and Protocols........................................................ 12 1.9. Table 2: Customer Pre‐Install Checklist ......................................................... 13

1.1. ABOUT THIS GUIDE

This guide contains critical information for Molecular Devices Customers, Customer Service Engineers, Applications Scientists, and others who need to properly prepare for the installation and use of software components of the Complete Imaging Solution.

1.2. DEFINITIONS

The computer that is connected to the Molecular Devices imaging hardware is referred to as the instrument workstation (it is also sometimes referred to as the acquisition computer). Any computers running the MetaXpress® Software, the MetaXpress® PowerCore™ Software or the AcuityXpress™ Software that are not connected to the Molecular Devices imaging hardware are referred to as personal workstations (they are sometimes also referred to as offline workstations). Both instrument workstations and personal workstations are considered clients of the database. The figure in section 1.4 describes the computer configuration of a multi‐user environment of Molecular Devices complete imaging solution, which combines the instrument workstation (provided with the Molecular Devices imaging hardware) and multiple personal workstations and servers.

Depending on the needs of your organization, Molecular Devices suggests a variety of computer configurations for multi‐user environments. A typical configuration for a multi‐user environment is described in the next section. Before attempting the installation of any component of the Molecular Devices Complete Solution for HCS, it is critical that the customers have been provided with an overview of the IT environment. Please have your Molecular Devices sales representatives put you in touch with an application scientist or support to schedule an overview of the document entitled Molecular Devices Complete Solution HCS IT Presentation.

Go to the knowledge base on the Molecular devices support page (http://www.moleculardevices.com/support.html) or call our help line at 1‐800‐635‐5577 (toll‐free, US only) or 1‐408‐747‐1700.


1.3. TYPICAL CONFIGURATIONS FOR MULTI‐USER ENVIRONMENTS

HCS generates vast amounts of data. Below is an example of configuration for a Core Facility lab or a medium throughput facility with 2 instruments, multiple screens per year, generating 100 GB per day, 5 days per week (~500 GB per week; ~20 to 30 TB per year) and requiring multiple databases and file storage locations.

This configuration is given as an example. Your throughput might be different, and you might not be using the MetaXpress PowerCore technology altering your specific configuration.

010010111010101010101010001010100010101101110010001010111100110111010010101001110101

Instrument workstation

Personalworkstation

Personalworkstation

n

Image storage MDCStore Data Managerdatabase

MetaXpress PowerCoreServer

MetaXpressPowerCore

Client1

MetaXpressPowerCore

Clientn

Pipes Pipes

Process 1 Process 1Process 2 Process 2

Reliable and dedicated networkwithout sub‐network

Min. 1 GB/sec.

Analysis code

Note: Virtual computer configurations are not supported.


1.4. NOTE ON THE INSTALLATION PROCESS

The installation of the ImageXpress® instrument and the Instrument Workstation will be performed by Molecular Devices service engineers.

The installation and maintenance of all software on other clients and servers, including Molecular Devices software and the database software, such as Oracle or MS SQL Server, should be performed by the customer.

CAUTION: To get the best performance from Molecular Devices Complete Solution for Cellular Imaging, customers must seek professional help with installation, configuration, and optimization of database server and client products. In particular, a database administrator with the proper expertise must configure and optimize, or tune, your database for your facility.

If you do not have a database administrator, contact Molecular Devices for a list of consultants.

The instructions provided with Molecular Devices documentation for Oracle database and Microsoft SQL are offered for guidance only as Oracle and Microsoft SQL are not products of Molecular Devices. For more information about database installation, security, operation, and optimization, contact the appropriate software vendor.


1.5. REQUIREMENTS BEFORE THE ON‐SITE INSTALLATION OF MOLECULAR DEVICES INSTRUMENTATION BY MOLECULAR DEVICES PERSONNEL

1 The customer is responsible for purchasing and pre‐installing all necessary software licenses for database client personal workstations. Computers, operating systems and database server software used to run the Molecular Devices Complete Solution should at least meet the minimum specifications outlined in the document entitled Molecular Devices Complete Solution HCS Computer Specifications available on Molecular Devices website or through your Molecular Devices Technical Support.

2 Installation of Molecular Devices software and software updates will require administrator privileges on all applicable computers.

3 If the customer elects to install Molecular Devices software with connection to an existing MDCStore database on a remote server the customer must pre‐install that server and open the firewall ports per Molecular Devices requirements (see Table 1: IT Network Ports and Protocols), to ensure proper communication with the instrument workstation.

4 The network connection between the instrument workstation and an existing customer database server or file server requires that all firewalls and routers be configured to allow data transfer between all of the applicable computers. Default ports for the database and file server manager are listed in Table 1: IT Network Ports and Protocols.

5 The customer must assign a routable IP address and DNS resolvable name path for the database and file server.

6 The customer will have the option of configuring connections by computer name (preferred) or IP address. If the customer elects to use IP addresses, it is recommended that they be static. If DHCP is required to be enabled, then a constant IP address must be assigned to each database and file server.

7 If configuring connections by computer name, first verify that you can ping the database and file server computers from the location where the instrument workstation will be installed, using the computer names.

Note: changing the computer name after establishing connections will cause errors, and information will need to be updated in the database.

8 The customer will be responsible for installation and maintenance of database software, such as Oracle or MS SQL Server, on their database server.

9 The database software employed, such as Oracle or MS SQL Server, must be of a version compatible with the MetaXpress Software, the MetaXpress PowerCore Software, or AcuityXpress Software as outlined in the document entitled Molecular Devices Complete Solution HCS Computer Specifications available on Molecular Devices website or through your Molecular Devices Technical Support.


10 Both the database server software as well as the operating system should be installed with U.S. English as the language setting. MDCStore database will not work with other language settings.

11 For optimal performance the computer hosting the MDCStore database should be dedicated to the Molecular Devices application.

12 To install MDCStore on a database server will require use of the “sa” (MS SQL Server) or “system” (Oracle) user login. After the MDCStore database schema is installed, Molecular Devices strongly recommends to create an MDCStore Lab Head account with administrative privileges and remove “sa” or “system” accounts from the MDCStore user list. Details of this procedure are described in the “Managing User Accounts and Groups” chapter of the MDCStoreTools Data Management Utility User Guide. The script needed for the MDCStore database installation is available on the installation media or from the knowledge base on the Molecular Devices support site at www.moleculardevices.com/support.html.

13 If the customer elects to use an Oracle database, the appropriate client software should be pre‐installed and tested on each of the applicable computers. A license for the database software should be purchased from the manufacturer prior to installation of MetaXpress Software or AcuityXpress Software, and should be available for installation on the instrument workstation at the time of system installation. Instrument workstations supplied by Molecular Devices include a single license of the MS SQL Server client.

14 The customer should establish ODBC system data source connections to the MDCStore database on all applicable computers.

15 Instrument workstations supplied by Molecular Devices are equipped with gigabit Ethernet cards. In order to ensure the full capability of data transfer, we highly recommend gigabit‐capable firewalls, routers and cabling (cat 6) for use with all applicable computers. Unreliable, non‐dedicated networks and communication across sub‐networks will greatly affect the performance of data transfer. Consult with our support team to determine the optimal set‐up for your infrastructure

16 The customer is responsible for account management and user access control between the instrument workstation and any database or file server computers.


1.6. DURING ON‐SITE INSTALLATION OF MOLECULAR DEVICES INSTRUMENTATION BY MOLECULAR DEVICES PERSONNEL

1 At the time of system installation, the customer is required to supply Molecular Devices with the information requested in Table 2: Customer Pre‐Install Checklist, to ensure the proper communication with the database server.

2 The customer must ensure that persons who will be responsible for database or file server installation and maintenance will be available at the time of system install and during scheduled training sessions.

3 Some IT departments require that computer names conform to corporate standards. If the name of the instrument workstation must be changed, for any reason, it should be changed during system installation. This will allow the on‐site Molecular Devices representative to properly configure computer connections with the new computer name.

IMPORTANT: If the computer name is changed, the customer risks loss of database connectivity, data corruption and/or data loss.

4 The customer is responsible for purchasing and pre‐installing all necessary software licenses for database client personal workstations. For minimum and recommended personal workstation specifications, please refer to the document entitled Molecular Devices Complete Solution HCS Computer Specifications available on Molecular Devices website or through your Molecular Devices Technical Support.

5 The instrument workstation provided by Molecular Devices is supplied with licenses for several different software applications (for example, Windows 7 OS, MS Excel, MS SQL Server, and so on). During on‐site installation, installation disks and license documentation for these software applications will be handed over to the customer. It is the responsibility of the customer to keep all of these supplied items in a safe place, and to make them available to Molecular Devices personnel, if software re‐installation is required for servicing the system. If the customer is unable to make these items available to Molecular Devices personnel when required for servicing the system, a replacement fee might be charged.

6 Create a dedicated drive or partition for data storage. Do not use the drive on which the computer OS is installed for image file storage or installation of the database.


7 Some IT departments require that users not have administrative rights on client computers. If this is the case the IT department must give full control (read, write, and modify) to all users for the following folders:

x:\MX (or whatever folder MX is installed in)

x:\Analysis,

x:\Assay

x:\Backup

8 Molecular Devices recommends having an Internet connection available on the instrument workstation during installation. An Internet connection enables Molecular Devices personnel to download the latest version of MetaXpress software, and obtain software registration codes required for the system installation. The installation process might be prolonged if an Internet connection is not available. The Internet connection can be removed after system installation is complete.

1.7. POST‐INSTALLATION REQUIREMENTS

1 The customer is responsible for installing the MetaXpress Software, MetaXpress PowerCore Software, and AcuityXpress Software on all personal workstations. Please refer to the appropriate Installation Procedures for instructions.

CAUTION: To get the best performance from Molecular Devices Complete Solution for Cellular Imaging, customers must seek professional help with installation, configuration, and optimization of database server and client products. In particular, a database administrator with the proper expertise must configure and optimize, or tune, your database for your facility.

If you do not have a database administrator, contact Molecular Devices for a list of consultants.

The instructions provided with Molecular Devices documentation for Oracle database and Microsoft SQL are offered for guidance only as Oracle and Microsoft SQL are not products of Molecular Devices. For more information about database installation, security, operation, and optimization, contact the appropriate software vendor.

2 The instrument workstation provided by Molecular Devices ships with anti‐virus software installed. It is the customer’s responsibility to keep the anti‐virus software configuration up‐to‐date, in order to avoid security risks and virus threats to the computer. Molecular Devices will not be held responsible for viruses or security attacks on the computer. Updating the virus definitions while the instrument workstation is in use can result in performance issues and should be avoided.

IMPORTANT: Stringent anti‐virus settings might affect the rate of data transfer or operation of the imaging instrument, the instrument workstation, the MDCStore database, or any client of the database. After setting the anti‐virus software, verify that the anti‐virus settings do not change the performance of the overall system (that is, without anti‐virus software)


3 To run the MetaXpress PowerCore Software, firewalls must permit UDP and TCP communications on the ports in use. Antivirus software needs to be configured to allow UDP and TCP transmissions on the ports in use. Please refer to Table 1: IT Network Ports and Protocols for details.

4 Molecular Devices support personnel might request third‐party software to be uninstalled from MetaXpress Software, MetaXpress Power Core Software, or AcuityXpress Software computers for troubleshooting purposes. In general, Molecular Devices highly recommends using the Instrument workstation for MetaXpress Software acquisition and analysis only. Running other applications concurrently with MetaXpress Software should be avoided.

5 The customer is responsible for installing database client software (Oracle or MS SQL Server) on personal workstations. The customer is also responsible for configuring database connections on such computers. For instructions on configuring database connections, see the MDCStore Database Schema Installation and Update Guide.

Note: Avoid installation of both Oracle and MS SQL on the same server.

6 The customer is responsible for maintaining and regulating user access between personal workstations, database servers, and file servers.

Note: Security login errors, such as domain updates should be checked for validity and the windows event should be monitored

7 The person responsible for updating and maintaining the MetaXpress Software, databases, and file servers must have administrator‐level privileges on all applicable computers.

8 Database maintenance such as, but not limited to, removing deleted data, re‐indexing, and backing up will diminish performance and should not be performed concurrently with acquisition or analysis.

9 Molecular Devices recommends that all Windows user accounts on all computers running the imaging software (MetaXpress Software, MetaXpress PowerCore Software, or AcuityXpress Software) should be given full access to any UNC path configured as a file server. The customer is responsible for any IT issues resulting from not following this recommendation. If the customer IT department configures multiple UNC paths with different permission they must attempt to configure the permissions hierarchy of the database and Windows users similarly.

10 All users must have full read/write/modify privileges to all the folders created during MetaXpress Software installation: C:\assay, C:\backup, C:\analysis, and the MetaXpress directory (such as, C:/MX; C:/MX2, C:/MX3, or C\MX4).

11 Windows workstations, analysis clients, and servers should be configured to never go into sleep, standby, or hibernate mode. The option to automatically restart the computer after a windows update should be disabled.

12 Molecular Devices recommends turning off automatic Windows updates on all acquisition computers, since this might cause a restart of the computer during the middle of an acquisition.


13 It is the sole responsibility of the customer to back up system data. The instrument workstation supplied by Molecular Devices includes a license of Norton Ghost (drive‐imaging software), for the purpose of creating a backup file of the instrument workstation hard drive only. This software needs to be configured to your specifications. This type of backup file is useful in the event of computer or hard drive failure, allowing faster restoration of system operation.

IMPORTANT: A back‐up of the system should be performed only when the instrument workstation or personal workstation is not in use.

14 It is the sole responsibility of the customer to backup data from all of computers running Molecular Devices software, including the instrument workstation supplied with the Molecular Devices imaging hardware.

15 It is the sole responsibility of the customer to monitor a space available for storage of data (database and file systems) and make sure that amount of free space always corresponds recommended criteria.

16 Customers who want to integrate the MDCStore database into their own corporate database, can request an open API document from their Molecular Devices sales representative. Database integration is the sole responsibility of the customer, and Molecular Devices cannot be held responsible for data corruption, loss, or failure caused by this process.

IMPORTANT: Molecular Devices is not responsible for backing up data, and cannot be held responsible for data loss or corruption, due to computer failure or any other cause.

If you experience any problems with an installation, please submit an online help ticket on the Molecular Devices support page (http://www.moleculardevices.com/support.html), or call our help line at 1‐800‐635‐5577 (toll‐free, US only) or 1‐408‐747‐1700.


1.8. Table 1: IT Network Ports and Protocols

Connection Between the MetaXpress or AcuityXpress Client(s) and the File Server

Protocol Port Function

TCP / IP 9200 (Default) Image / File Transfer

Note: One port needs to be made available for each fileserver. Each fileserver needs a dedicated port.

Connection between the MetaXpress Client(s) and the Database Server


TCP / IP 1433 MS SQL Sever Database

TCP / IP 1521 Oracle Database

Connection between the MDCStore xChange Service and the clients


TCP / IP 8080 Image / File Conversion

Connection between the MetaXpress PowerCore Servers and Clients

All firewall software on the MetaXpress PowerCore server, including Windows Firewall and other firewall applications, must be configured to permit the license key driver (spnsrvnt.exe) to send and receive TCP/IP communications

on port 6002

The default port for the MetaXpress PowerCore clients is 20000

Note: Ports are defaults claimed by those respective database software packages and are not guaranteed by Molecular Devices.


1.9. Table 2: Customer Pre‐Install Checklist

Please fill out the following information and have it available during on‐site installation and training.

Full computer name of acquisition computer

IP address of acquisition computer (static recommended)

Internet connection established on the acquisition computer

Yes

No

Database installed

Yes

No

Database program being used

MS SQL Server

Oracle

Version of the database server application installed

Version of the ODBC driver

Full computer name and path of database computer

IP address of database computer (static recommended)

File server installed

Yes

No

Full computer name and path of file server

IP address of file server computer (static recommended)

Port number assigned for file server (9200 or higher suggested)

Documents

Molecular Devices Complete Imaging Solutionmdc.custhelp.com/euf/assets/content/Molecular Devices Complete...environment of Molecular Devices complete imaging solution, which combines