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Module 23: Proportions: Confidence Intervals and Hypothesis Tests, Two

Samples

This module examines confidence intervals and hypothesis test for two independent random samples for proportions.

Reviewed 06 June 05 /MODULE 23

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P1 = Parameter for population one P2 = Parameter for population two

x1 = Number in sample one with the characteristicx2 = Number in sample two with the characteristic

n1 = Total number in sample onen2 = Total number in sample two

p1 = x1 / n1, estimate for sample onep2 = x2 / n2, estimate for sample two

Proportions: Two Independent Random Samples

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Hypothesis Test: Proportions from two samples

H0: P1 = P2 vs. H1: P1 P2

p2 = x2/n2, p1 = x1/n1

The test is based on:

1 2

1 1 2 2

1 2

(1 ) (1 )

p pz

p p p pn n

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Example: AJPH, Nov. 1977;67:1033 - 1036

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Proportions for Two Independent samples1. The hypothesis: H0: PM = PF vs. H1: PM PF

2. The assumptions: Independent random samples

3. The -level: = 0.05

4. The test statistic:

5. The rejection region: Reject if z not between 1.96

(1 ) (1 )M F

M M F F

M F

p pz

p p p pn n

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6. The test result:

7. The conclusion: Accept H0 : PM = PF , since z is between ±1.96

0.85 0.84 0.01

0.85(1 0.85) 0.84(1 0.84) 0.85(0.15) 0.84(0.16)

1,109 2,063 1,109 2,063

0.01 0.01 0.01

0.0134220.000115 0.000065 0.000180

0.745

z

z

MM

M

FF

F

x 947p = = = 0.8539 = 0.85

n 1,109

x 1,736p = = = 0.8415 = 0.84

n 2,063

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Confidence Interval for PM - PF

= 0.05

MM

M

FF

F

x 947p = = = 0.8539 = 0.85

n 1,109

x 1,736p = = = 0.8415 = 0.84

n 2,063

(1 ) (1 )1.96

0.95(1 ) (1 )

1.96

M M F FM F M F

M F

M M F FM F

M F

p p p pp p P P

n nC

p p p pp p

n n

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(1 ) (1 ) 0.85(0.15) 0.84(0.16)

1,109 2,063

0.0000115 0.000065 0.013

M M F F

M F

p p p p

n n

(0.85 0.84) 1.96(0.013) (0.85 0.84) 1.96(0.013) 0.95

0.01 0.025 0.01 0.025 0.95

0.015 0.035 0.95

M F

M F

M F

C P P

C P P

C P P

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Example: Two VaccinesIn testing two new vaccines, for one group 137 of 200 persons became infected. For the second group, 98 of 150 became ill. Test the hypothesis that the two vaccines are equally effective.

1. The hypothesis: H0: P1 = P2 vs. H1: P1 P2

2. The assumptions: Independent random samples

3. The -level : = 0.05

4. The test statistic:

2

22

1

11

21

)1()1(

n

pp

n

pp

ppz

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5. The rejection region: Reject H0: P1= P2, if z is

not between ±1.96

6. The result:

7. The conclusion: Accept H0: P1 = P2 , since z is between ±1.96

685.0200

137

1

11

n

xp653.0

150

98

2

22

n

xp

1 2

1 1 2 2

1 2

0.685 0.653

(1 ) (1 ) 0.685(1 0.315) 0.653(1 0.347)200 150

0.032 0.032

0.050890.001079 0.001511

0.629

p pz

p p p pn n

z

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Example: AJPH, Sept. 1998;88:1319 - 1324

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Hypothesis test for proportion of Asthma or Wheezy Bronchitis in Social Class I vs. Social Class II

nI = 191 nII = 1,173

pI = 0.047 pII = 0.078

1. The hypothesis: H0: PI = PII vs. H1: PI PII

2. The assumptions: Independent Random Samples Binomial Data

3. The -level : = 0.05

4. The test statistic:

Hypothesis Test

(1 ) (1 )I II

I I II II

I II

p pz

p p p pn n

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5. The rejection region: Reject H0: PI = PII , if z is not between ±1.96

6. The result:

7. The conclusion: Accept H0: PI = PII , since z is between ± 1.96

0.047 0.078 0.031

0.047(0.953) 0.078(0.922) 0.0002 0.0001

191 1,173

0.031

0.0172

1.80

z

z

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  nI = 191 nII = 1,173

pI = 0.047 pII = 0.078

Confidence Interval for PI - PII

(1 ) (1 )1.96

0.95(1 ) (1 )

1.96

I I II III II I II

I II

I I II III II

I II

p p p pp p P P

n nC

p p p pp p

n n

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0.047(0.953) 0.078(0.922)0.047 0.078 1.96

191 1,1730.95

0.047(0.953) 0.078(0.922)0.047 0.078 1.96

191 1,173

0.031 1.96 0.0002 0.0001 0.031 1.96 0.0002 0.0001 0.95

0.031

I II

I II

P P

C

C P P

C

1.96(0.0162) 0.031 1.96(0.0162) 0.95

0.0628 0.0008 0.95

I II

I II

P P

C P P