Modification of Laser Alignment of Cranial X-Rays Intraoperatively

Pamela Tebebi

Advisor: Peter Konrad, MD/PhD

Project Goal

Design an accurate sighting system by means of laser sighting alignment for the intraoperative X-ray taken of brain stimulator implants.

Problem Definition

Background of Deep Brain Stimulation (DBS) for Movement DisordersWhat is DBS?

– A surgical procedure whereby electrodes are permanently implanted in particular parts of the brain and continuous stimulation administered by a small electric unit (generator) that is implanted under the skin of the chest

– It is a way to control the abnormal activity of particular brain cells in the immediate vicinity of the stimulating electrode without destroying brain tissue

How will this help movement problems– Goals of DBS are to improve the control of movement

on the side opposite the stimulator– Depending on the type of movement disorder, this

may result in loss of tremor, loss of rigidity, loss of dyskinesia or dystonia

Background continued

Risk of DBS– Most serious is bleeding into the brain causing headache,

paralysis, coma, or death

– Infection (10%)

– Malfunction of stimulator

– Movement of the electrode

Significance of the Project

Want to design an accurate sighting system by means of laser sighting alignment for the intraoperative X-ray taken of brain stimulator implants.

True significance of taking an X-ray is to compare the stimulation site to the final site if implant so as to verify that the implant is still at the designated

Current DBS Device

Developed by FHC, Inc

(specialize in metal and glass microelectrode, needles and instrumentation for cellular research

Does not allow for alignment of

mT Platform is design from importing CT and MR scans into the mT Platform Planning Software which automatically designs a patient-customized adaptor to fiducial marker based stereotactic system that aligns the mT Platform Drive System to reach selected target

microTargeting Platform System (mT Platform)

Proposed Methods to Align X-ray : Method 1

– Attaching on fiducial markers can be cumbersome and affect stability of mT Platform

mT Platform

Fiducial

Proposed Methods to Align X-ray : Method 2

mT Platform

Location of fiducial

Mounting Hub

Positioner- aid in the path probe will travel to desired target

Alignment device

AC-PC line

Current Status

Waiting to here from Ron Franklin, senior engineer at FHC to determine how adaptable the new method would be to their mT Platform System

Work Completed

Research on other methods to align X-ray involve using mirror that can be rotated to hit desired target

Other methods involve using a collimated laser beam to mimic x-ray beam path

Current Work

Complete DesignSafe Analysis

Future Work

Set up appointment with Ron Franklin to determine if anymore adaptations to the device are necessary