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By eliminating the disadvantages ofearlier methods, the Triosorb Spongehas achieved a real breakthrough inthyroid testing. It is an in vitro testunmatched in accuracy, speed andconvenience.

Accuracy : Because factors such as redblood cells and exogenous iodine havebeen eliminated from consideration inthe Triosorb Test, it is unmatched inaccuracy.

Speed: With only 3 washes and noneed for double pipettings, shakers, orincubators, the Triosorb Test can be

•.

revolutionizedthyroidtesting!

more rapidly performed than any otherT-3 test.

Convenience: Triosorb is in a disposable kit ready for immediate use atroom temperature, making it the simplest and most convenient thyroidfunction test to perform.McAdams* reported that "The resin

sponge (Triosorb) technique is superior to the erythrocyte method for performing the I131T3 test in terms of

simplicity, convenience and elimination of errors characteristic of theerythrocyte procedure."

Triosorb is available to all doctors,hospitals and clinical laboratories-AEC licensing is not required.BecauseTriosorb will enable far more screenings to be performed, this proceduremay soon become as standardas today's blood counts and

urinalyscs.•McAdams,G. B. and Reinfrank, R. F., Jrnl. Nuclear Med.,5:112, Feb., 1964.

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Scanning speeds continuously variable to200 inches per minute ( 500 cm/min. ) ;adequate shielding even for high energygamma emitters (up to 3 inches lead and 1inch steel); high resolution crystals (9 percent or better); accurate, reproducible scanning speeds and line spacing; no scallopingat any speeds; low background crystals (2inch thick pure Nal light pipe); Gamma-

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UNIONCARBIDE

Early in 1965, Neisler Laboratories,Inc., an 80-year-old ethical pharmaceu

tical company, was purchased byUnion Carbide Corporation, long recognized as one of this country's

leaders in industrial nuclear research.As a result of this action, many ofthe radioisótopos produced byUnion Carbide's nuclear reactor at

Tuxedo, New York, will soon becomeavailable for use in nuclear medicine.Pharmaceutical processing will be carried out adjacent to the reactor wherethe radioisotopes are created, and theuseful products will be distributed byNeisler, a company whose personnelare completely oriented to serving theneeds of the medical profession.

directlyfromournuclearreactortoyourradioisótopolaboratoryNeisler Laboratories now offers thefirst of its line of nuclear reactor products for medicine-the NEIMOTEC T.M.("Mo/99mTc) Generator-for the

convenient production of short-livedtechnetium-99m, one of the most use

ful radioisotopes available for clinicalinvestigation. Write for details.

NEISLER LABORATORIES, INC.Subsidiary of Union Carbide Corp.P.O. Box 433, Tuxedo, New York 10987

dupharnuclearPharmaceuticals

WhyHolland?Why should you look forisotopes in Holland?Well, because in Holland youwill find a company,specialized in isotopeproduction.

The name is Philips-Duphar.Twelve years of isotopeproduction guarantee thekind of experience you canrely on : Nuclear Pharmaceuticals for medicine ...C14/H3 compounds andradiochemicals forresearch ... radiographiesources for industry ...Representatives in 70countries and airwaydespatch make Philips-Duphar your next-doorsupplier. Write for completedocumentation andprice lists.

N.V. PHILIPS-DUPHARAMSTERDAM HOLLANDApollolaan 151Telegrams :Vitamine-AmsterdamTelex: 14232

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RADIOCHEMICAL products formedical research and practise

SelenomethioninePancreas scanning agent

The metabolism of selenomethionineappears to be closely similar to that ofmethionine and on administration thecompound is rapidly incorporated intothe pancreatic enzymes. By using selenomethionine labelled with the gammaemitting radioisotope selenium-75.

successful visualisation of the humanpancreas can be obtained.Scans of the pancreas require about250 jac of L-Selenomethionine-SeTS.The product is supplied as a sterileaqueous solution (code SC.1 P), specificactivity 100-400 mc/mM.

THE RADIOCHEMICAL CENTREAmersham, Buckinghamshire, England

Telephone: Little Chalfont 2701 Telex: 83141 Active Amersham Cables: Activity Amersham Telex

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IX

Photoscan of lungs of female patient, aged 50, showing pulmonary emboli, taken August 13, 1965.*

nowyouseeitseeendeneeofpulmonaryembolism

ALBO10TOPE-LSSQUIBBAGGREGATEDRADIO-IODINATED(I131)ALBUMIN(HUMAN)

INVESTIGATORSin a recent clinical study recommendlung scanning as one of the routine screening procedures in the diagnosis of pulmonary embolism

because "it appears that the lung scan can point to thesite of embolie lesions before signs of lung infarctionare recognizable on plain chest films."1

Lung scanning is much simpler—andless hazardous—than pulmonary arteriography. Simply inject Atbumo-tope-LS just prior to scanning. (Cardiac catheterizationis not required.)

The requirements for the ideal radiopharmaceuticalfor scanning pulmonary ¡ufareishave been enumerated.2Albumotope-LS meets them all:

•contrast—gooddifferentiation between normal and in-farcted lung tissue

•selectivity—goodconcentration in the lung with lowradiation background in other organs

•rapid clearance from the blood stream —if the infarctconcentration of radioactivity is lower than that in theblood

•balance—suitable gamma energy for scanning withminimal radiation dosage to the patient

•safety—non-toxicWith radioiodinated I131albumin "lung scanning has

been proven to be simple, rapid and safe in the diagnosis,localization and ultimate fate of pulmonary emboli."3

v:

Chest x-ray of same patient taken same day; no radiographie evidence of pulmonary embolism.'

nowyoudon'tbeforeitappearsonchestfttms

Dosage and Scanning Procedure: Recommended scan doses of ISOto300 microcuries of aggregated radioiodinated U ':; ' ) albumin depending on the instrumentation available and the technics employed.Scanning immediately follows administration of slow intravenousinjection. Patient may be placed in a prone or supine position.Side Effects and Précautions:There have been no reported cardiovascular or other untoward effects attributable to Albumotope-LS.Extensive clinical use of Albumotope-LS has not borne out thehypothetical possibility that particles of large size might induce deleterious cardiovascular or cerebrovascular effects. The productappears to possess no antigenic properties. One patient with aknown history of angioneurotic edema, who had been given Lugol'ssolution in conjunction with aggregated radioalbumin similar toAlbumotope-LS, developed urticaria.

Radioisotopes should not be used in pregnant women, nursingmothers, or in patients under 18 years of age unless indications arevery exceptional.

Available: As a sterile, non-pyrogenic, aqueous suspension. Eachcc. contains approximately 1 mg. aggregated human serum albuminlabeled with 800-1500 microcuries of iodine-131 at time of manufacture. Also contains 0.9% benzyl alcohol as a preservative.References: (1) Haynie, T. P.; Hendrick, C. K., and Schreiber,M. H.: J. Nucí.Med. 6:613, 1965. (2) Quinn, J. L., et al.: J. Nucí.Med. 5:1, 1964. (3) Sabiston, D. C., and Wagner, H. N.: Ann.Surg. 760:575, 1964.

•Illustrationsfurnished through the courtesy of George V. Taplin,MD.. Harbor General Hospital, Terranee, California.

SQJJIBB Squibb Quality—the Priceless Ingredient

•ANNOUNCINGNEW REPRINTSNEUROSURGICAL CLASSICSNow AvailableCompiled by Robert H. Wilkins, M.D., AssistantResident in Neurosurgery, Duke University Medical Center, Durham, North Carolina, under theauspices of the Harvey Cushing Society and TheJournal of Neurosurgery, 523 p. cloth. . . .$27.50.vEUROSL'RGICAL CLASSICS is a collection of 52 ofthe most outstanding written contributions in the field ofneurological surgery. The original works have beenduplicated as closely as possible, but for uniformity andconvenience the 15 classical works that were originallyprinted in other languages have been translated intoKnglish. To make the volume more useful, an appendixhas been added which includes more than 200 additionalreferences related to the historical development of neuro-surgery. NEUROSURGICAL CLASSICS can be used asa starting point for the review of any number of neuro-surgical topics.

Antonio Hernandez MorejónHISTORIA BIBLIOGRÕFICAde la MEDICINA ESPAÑOLANow AvailableCloth bound set in 7 volumes $18.5.00

A facsimile of the Madrid 1842-1845 editionWith an introduction by Francisco Guerra, M.D.,D.Sc., Ph.D., University of Mexico. Fellow, TheWellcome Trust, The Wellcome Historical Medical Library, London.More than a century has gone by since its publication,but despite progress in historical and bibliographicaltechniques the work of Hernandez Morejón remains astandard of accuracy in most entries. The material,which is organized chronologically, covers the evolutionof Spanish medicine, with articles on Ihe authors andtheir works and, in addition, a good review of their contents. Medical publications pertaining to America fromthèfifteenth century are included, and the number ofauthors and books surveyed is impressive. A general alphabetical index, whose lack handicapped users of thebibliography, has been recently provided.The Sources of Science No. 9

Anastasio ChinchillaANALES HISTÓRICAS de laMEDICINA en GENERAL yBIOGRÕFICO-BIBLIOGRÕFICOSde la ESPAÑOLA en PARTICULARNow Available

Volumes 1-4(Vol. 1 in 3 vols, and Vol. 2 in 2 vols.)

Cloth bound set $200.00A facsimile of the Valencia 1841-1846 edition

With an introduction by Francisco Guerra, M.D.,D.Sc., Ph.D., University of Mexico. Fellow, TheWellcome Trust, The Wellcome Historical Medical Library, London.Chinchilla's work. Anales históricas de la Medicina engeneral, y biografico-bibliográficos de la Españolaenparticular, was printed five years after the death ofHernandez Morejón. Chinchilla published eight smallfolio volumes, two of which were devoted to a generalhistory of medicine, one to a history of surgical procedures, and the remainder to Spanish medicine, includingmany American authors. Although Chinchilla organizedhis work in precisely the same fashions as HernandezMorejón, he treated some works in a manner quite different from that of his predecessor. It is easy to sympathize with Chinchilla's bitterness when charges of plagiarism were made against him.The Sources of Science No. 8

THE WORKS OFWILLIAM HARVEY, M.D.Now AvailableTranslated from the Latin with a life of theAuthor by Robert Willis624 pp. cloth London 1847, (Reprint 1965) $25.00William Harvey's great and diverse merits as a physiologist ever demand reiteration. As a clever and assiduousexperimentalist he has long been renowned. No less important to securing his many achievements were a vastbreadth of vision, an exceptionally wide competence asa practical naturalist ana a clarity, forcefulness andoriginality of thought and expression which has seldombeen equalled. All of these factors are thoroughly illustrated in the famed Willis translation of THE WORKSOF WILLIAM HARVEY.The Sources of Science No. 13

John TyndallESSAYS ON THEFLOATING-MATTER OF THE AIRIN RELATION TOPUTREFACTION AND INFECTIONAvailable Fall 1966Reprinted from the New York Edition of 1882.With a New Introduction by Raymond N.Doetsch, Department of Microbiology, University of Maryland, College Park, Maryland. 1966.cloth $15.00In these five essays, composed between 1870 and 1878,John Tyndall implemented a revolutionary approach tothe science of bacteriology: the physical.The bacteriologist of today, of course, employs quitereadily both chemical and physical methods in his experiments. John Tyndall well deserves our attention asa father of this latter approach, that has since broadenedthe science considerably.The Sources of Science Ño. 16

lt>nazPhilipp SemtnelweisDIE AETIOLOGIE, DER BEGRIFFUND DIE PROPHYLAXISDES KINDBETTFIEBERSNow Available

Pest, Wien & Leipzig, 18<ilReprinted from the 1861 edition, with a new introduction by Alan F. Gultmacher, M.D. Ì966.Approx. 550 pp. cloth $12.00Ign.iz Semmelwcis, one of the truly tragic figures in thehistory of medicine, wrote what has since been recognized as one of the classical descriptions of a disease, itscause, and ils prevention. Based on overwhelming evidence from his own experience as well as from themedical literature of the I840's and 18"iO's,Semmelwcisclearly noted the nature of the dreaded childbed fever,so common in the large, crowded hospitals of his day.Before Ihe work of Pasteur became generally knownand before Lister began his studies. Semmelweis, in effect, announced the doctrine of antisepsis.An unusually rich single source for one of the greatintellectual battles of the nineteenth century medicalworld.The Sources of Science No. 19

Pierre-Louis Moreau de MaupertuisTHE EARTHLY VENUSNow AvailableTranslated by Simone Brangier Boas from VénusPhysique; with notes and introduction byGeorge Boas, Professor Emeritus of the Historyof Science, The Johns Hopkins Universitv.Approx. 128 pp. cloth $8.50A pioneer in tue study of genetics, Pierre-Louis Moreaude Maupertuis hypolhcsi/ed much of what has becomeIhf basis of modern genetics. Had he not incurred Ihrwrath of Voltaire, his would have been a better-knownname today; instead, he is nearly forgotten.Sensitive, hesitant, deeply influenced by the social mood,and often rallier a romantic, Maupertuis managed tocome up with a bold challenge to geneticists of his day.His investigations led him lo assert that offspring werethe result of characteristics inherited from both parents,which were produced by particles carried within eachindividual's germ cells.The Sources of Science No. 29

Edmund B. WilsonTHE CELL IN DEVELOPMENTAND INHERITANCEA'ou' AvailableA reprint of the first edition, 1896, with a newforeword by Dr. H. S. Muller, Nobel Prize winner in Physiology and Medicine, 1946; Member,Institute for Advanced Learning in the MedicalSciences, City of Hope, Duarte, Calif., 1865; Distinguished Service Professor, Emeritus, IndianaUniversity. 422 pp. cloth bound $17.50The measure of Wilson's book is not only in his compilation of the facts and hypotheses concerning the cell,but in his insight, his far-ranging search of all informational sources, high and low, his stern self-criticism, andhis genius for organization.Wilson's spirited integration of imagination and scientificfactualism make this book exciting, as well as encyclopedic.The Sources of Science No. 30

¿^JOHNSON REPRINT CORPORATION 111 Fifth Avenue, New York, N.Y. 10003—

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Original articles in clinical medicine, basic and clinical medicalresearch, physics and chemistrydealing with the use of isotopesin humans, and articles on relatedsubjects. The latter includes do-simetry, instrumentation, protection, techniques, biologic effectscontributing to the use or effectsof isotopes in clinical medicine orthe clinical effects of ionizingradiation.

George E. Thoma, M.D., St. Louis—Editor

G. O. Broun, Jr., M.D., St. Louis, Titus C. Evans, Ph.D., Iowa City,

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PublishedMonthly

XVI

USEARMAC4

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The Armac Scintillation Detector is a large-sample-volumedetector ideally suited for in vivo tracer studies using gamma-emitting isotopes. Its near 4-pi counting geometry and highcounting efficiency make it useful for work with low levels ofradioactivity, where it provides accurate and meaningful measurements in short counting periods. •Armac systems are widelyused to count radioactivity in small laboratory animals in studiesof retention and excretion of gamma-emitting isotopes. Theyalso quickly and accurately determine the presence of low levelsof radioactivity in bulk samples of foods, liquids, wastes andtissue, and are used to study changes in the amount of circulating radioactivity in the human bloodstream. •There are tenArmac Detector Systems available to meet your specific counting needs. Any one of them can be readily modified or expandedto meet changing research requirements. For complete information contact your Packard Sales Engineer or request Bulletin1024 L from Packard Instrument Company, Inc., 2200 Warren-ville Road, Downers Grove, Illinois 60515, or Packard InstrumentInternational S.A., Talstrasse 39, 8001 Zurich, Switzerland.

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Advertising Index

Journal of Nuclear Medicine

August, 1966

Abbott LaboratoriesNorth Chicago, Illinois IFC, i

Duphar Nuclear CorporationAmsterdam, Holland viii

Johnson Reprint CorporationNew York, New York xv

Neisler Laboratories, Inc.Tuxedo, New York vi, vii

Nuclear-Chicago CorporationDes Plaines, Illinois BC

Nuclear Consultant CorporationSt. Louis, Missouri v, IBC

Ohio-Nuclear

Cleveland, Ohio

Packard InstrumentChicago, Illinois

.111

XVH

Picker-X-Ray CorporationWhite Plains, New York

Radiochemical CentreBuckinghamshire, England .IX

Squibb, R. R. & SonsNew York, New York xii, xiii

TracerlabWaltham, Massachusetts xviii

XVlll

NOW MATCHEDCONTROLfor GreaterAccuracywith

TBI by Nuclear Consultants. The easiest,most reliable in vitro thyroid function testof them all ... now with matched control forgreater accuracy.

The matched control serum supplied inthis highly effective kit provides a newindividually calculated normalizing factor.The control serum is quickly and easilycompared to the test serum after countingby simply dividing the net patient serumcount by the net TBI control count andmultiplying by the normalizing factor.

Net patient countNet control count

normalizi factor = TBI

TBI eliminates exact stop-watch timing ofeach step. Saves valuable technician timefrom start to finish. And TBI costs less, too.

COMPARE TBI•New butler produces exceptional stabil

ity and reproducibility.•Unmatched accuracy* for hypothyroid

—euthyroid —or hyperthyroid evaluation. TBI Buffer eliminates variables dueto problems of serum handling.

•Time and temperature are not critical.•Takes less technician time than any

other T-3 test —almost half.•Count patient serum only once.•TBI low cost permits use as a screening

test.TBI —now with Matched Control. Anotherdemonstration of leadership in radio-pharmaceutical products by the specialist—NCC.•Intests performed on over 2200 patient«, the TBI

test was reported in agreement with fìnalclinicaldiagnosis in over 90% of the cases. Ref.: Scholer,J. F., J. of Nuclear Med., May '63, p. 192.

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The future can onlymake the Pho/GammaScintillation Cameraeven more valuable

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Since 1962, Pho/Gamma has put its speed to use incutting through ever-increasing clinical work loads.Example: scintiphotos of radioisotope distribution in theliver, brain, or kidneys take from 2 to 8 minutes. Andeven now, Pho/Gamma is opening new areas of diagnosticinvestigation. Examples: dynamic studies such ascerebral and cardiac blood flow, new modes of datamanipulation and analysis, and positron tomographywith the soon-to-be-available positron attachment.

To learn what Pho/Gamma is doingnow and will do in the future, consultyour Nuclear-Chicago sales engineeror write to us. «uc,»-.-,,.

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