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MIMM BITES A NEWSLETTER OF McGILL’S MICROBIOLOGY & IMMUNOLOGY DEPARTMENT
JUNE 2015
1
FROM THE CHAIR’S DESK
Dear MIMMers,
With this newsletter we close the 2014-15 academic year
and start to prepare the arrival of the summer break! To
all, I wish you a relaxing, reinvigorating and inspiring
summer break.
We saw amazing discoveries during last year: many
papers to pick from McGill and beyond. One of my
favorites is a paper not exactly in Microbiology and
Immunology but full of “life lessons”, from the
Romesberg group from the Scripps. In this Nature paper
(2014; 509: 385. doi: 10.1038/nature13314), this group
reports a semi-synthetic organism incorporating a couple
of unnatural base pairs in addition to the traditional
A/T/G/C. Practically, they were able to expand the “code
of life” on earth from 4 bases to 6 with the implications
on new ways for life transmission, resistance to
pathogens, etc. As said before, what natural selection
was not able to do in 4 billion years, scientists were able
to do in 12 years (the time this project went on). That is
the other lesson: it took this group 12 years to develop this new life code against all odds and with many
difficulties to get funding from NIH and other traditional sources. Peer review may not always identify
breakthroughs. But we must always surrender to the data. Excellent science always pays off. I hope that
this group is now getting all the funding that they need and did not get before.
In line with this story, please enjoy below a feature article on the 4th MIMM Graduate Research Day
written by one of our Work Study Student (Astha Agarwal). Such an event was a great success, portraying
the excellent research done in the labs of our department. I encourage you to continue the pursuit of the
highest standards of innovation and excellence and work towards your dream discovery!
Have a great summer!
Quim
MIMM BITES A NEWSLETTER OF McGILL’S MICROBIOLOGY & IMMUNOLOGY DEPARTMENT
JUNE 2015
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RESEARCH
Publications
1. Brannon JR, Burk DL, Leclerc JM, Thomassin JL, Portt A, Berghuis AM, Gruenheid S, Le Moual H. Inhibition of outer membrane proteases of the omptin family by aprotinin. Infect Immun. 2015 Jun;83(6):2300-11. doi: 10.1128/IAI.00136-15. Epub 2015 Mar 30.
2. Monat C, Quiroga C, Laroche-Johnston F, Cousineau B. The Ll.LtrB intron from Lactococcus lactis excises as circles in vivo: insights into the group II intron circularization pathway. RNA. 2015 May 8.
3. Richard J, Veillette M, Brassard N, Iyer SS, Roger M, Martin L, Pazgier M, Schön A, Freire E, Routy JP, Smith AB 3rd, Park J, Jones DM, Courter JR, Melillo BN, Kaufmann DE, Hahn BH, Permar SR, Haynes BF, Madani N, Sodroski JG12, Finzi A. CD4 mimetics sensitize HIV-1-infected cells to ADCC. Proc Natl Acad Sci U S A. 2015 May 4. pii: 201506755.
4. Xia J, Gill EE, Hancock RE. NetworkAnalyst for statistical, visual and network-based meta-analysis of gene expression data. Nat Protoc. 2015 Jun;10(6):823-44. doi: 10.1038/nprot.2015.052. Epub 2015 May 7. This article is featured on the cover of the June 2015 issue of Nature Protocols:
(http://www.nature.com/nprot/journal/v10/n6/covers/index.html)
FACES OF EXCELLENCE
Dr. Robert Murgita Professor
How long have you been with the Department?
A lot longer than originally expected when I arrived here full-time in 1979/80 from the Wigzell lab at the Karolinska Institute in Sweden.
What is your job description?
In the past, I have assumed administrative roles of the Department Vice-Chair (1983), acting Chair (1984), and Chairman (1984-94). As CP Chair of Biotech and Director of McGill’s Office of Biotech (1989-92), I established the Sheldon Biotech Center.
I have always been interested in scientific entrepreneurship, which I promote actively. In collaboration with McGill, I started a small spin-off company to commercialize a therapeutic drug candidate (1991). It has now evolved into Merrimack Pharmaceuticals that trades on Nasdaq with a market cap exceeding $1bn.
My research focuses on the use of artificial intelligence to design software that will predict new small molecule drug candidates.
MIMM BITES A NEWSLETTER OF McGILL’S MICROBIOLOGY & IMMUNOLOGY DEPARTMENT
JUNE 2015
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ANNOUNCEMENTS
What do you look forward to when you come to work every day?
Exposing students both in the classroom and in the laboratory to the excitement of good science and its real-world applications. Engaging in intellectual discussions with bright and enthusiastic students (and a lot of coffee!).
Winners of the SWI Art Contest! Congratulations to MIMM Students, did AMAZING in the Small World Initiative cover design contest, winning first and second places and one of the honorable mentions! To see the McGill designs, click here.
Congratulations to Dr Mark Wainberg as his candidature for the Canadian Society for Microbiologists Murray Award has been selected unanimously by the members of the evaluation committee. As the recipient of this award, Dr Wainberg will present a 40 minute talk at the CSM Annual General Meeting at the University of Regina from June 15 to June 18, 2015.
Erica Ma, U3 MIMM student, received a CIHR Summer Studentship Award to work in Dr King’s lab this summer. The title of her project is “Identification of novel cytokine-producing leukocytes using multidimensional flow cytometric analysis”.
Alexandre Meli, PhD candidate, received a 3 year FRQS Doctoral Award to complete his PhD in Dr King’s lab. The title of his project is “Integrin mediated induction and maintenance of T follicular helper cells”.
MIMM BITES A NEWSLETTER OF McGILL’S MICROBIOLOGY & IMMUNOLOGY DEPARTMENT
JUNE 2015
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Congratulations to Isabelle Desloges (cosupervised by Le Moual and Gruenheid) on winning the Wilfred Yaphe Award for best M.Sc. Graduate student seminar for 2014/2015!
Congratulations to Alessandra Ricciardi (supervised by Dr. Ndao) on winning the
Wilfred Yaphe Award for best Ph.D. Graduate student seminar for 2014/2015!
Deeva Uthayakumar, who will be working on a project assessing the biological role
of bacterial group II introns in Dr Cousineau’s lab, won the Ralph Steinman SURA.
Congratulations Deeva!
Dr Gruenheid was selected to receive the 2015 recipient of the SALTISE
Best Practices & Pedagogical Innovators Award – University level. The
SALTISE Best Practices & Pedagogical Innovators Award recognizes
educators who stand out as leaders in the promotion of academic
excellence, use of innovative pedagogies, and support of their academic
communities. Congratulations Dr. Gruenheid!
MIMM BITES A NEWSLETTER OF McGILL’S MICROBIOLOGY & IMMUNOLOGY DEPARTMENT
JUNE 2015
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Dr. Donald C. Vinh was the recipient in December 2014 of the 2013-2014 NIAID
Merit Group Award as a member of the GATA2 Discovery Group (for outstanding
clinical and basic research leading to the discovery and characterization of
GATA2 Deficiency). Congratulations!
Tyler Cannon, U3 MIMM student, has been awarded a CSM
undergraduate award. This award is to "recognize outstanding
promise in an undergraduate student for early career contributions
to microbiology and to encourage continued interest in
microbiology." He will accept the award at the awards ceremony at
the CSM meeting in Regina in June. Congratulations Tyler!
Francois Coulombe (PhD graduate) was awarded two Convocation Prizes:
- Governor General’s Gold Medal, conferred upon the most outstanding
McGill graduate receiving a Doctoral degree in 2014-2015 in any
discipline.
- Gordon A. Maclachlan Prize, conferred an outstanding McGill graduate
receiving a Doctoral degree in 2012-2013 in any discipline of the
Biological and Health Sciences.
The prizes were announced at the Spring Convocation held on May 29th.
Congratulations Francois for such an achievement!
Congratulations to Drs Jim Gleason, Masad Damha and Andrew Mouland for their FQRNT Team Grant
for “Développement des hybrides bifonctionnels pour le traitement du VIH latent”.
MIMM BITES A NEWSLETTER OF McGILL’S MICROBIOLOGY & IMMUNOLOGY DEPARTMENT
JUNE 2015
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Graduate Research Day
Giustino Carnevale Jonathan Dunn Alessandra Ricciardi Oral Presentation – 1st Prize Oral Presentation – 2nd Prize Oral Presentation – 3rd Prize
Marija Landekic Kaitlin Anstett Poster Presentation – PhD Category Poster Presentation – PhD Category
1st Prize 2nd Prize
MIMM BITES A NEWSLETTER OF McGILL’S MICROBIOLOGY & IMMUNOLOGY DEPARTMENT
JUNE 2015
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Isabelle Desloges Emily MacLean Poster Presentation – MSc Category Poster Presentation – MSc Category 1st Prize 2nd Prize Special Coverage: MIMM Graduate Students and Post-Doctoral Fellows Unite In Fourth Annual
Graduate Research Day
Story and Photos by Astha Agarwal
Masters and Ph.D. students, and postdoctoral fellows presented their research through poster
and oral presentations during the fourth annual MIMM Graduate Student Research Day on Friday, May
29.
Students were judged by postdoctoral fellows in three categories: M.Sc. Poster, Ph.D. Poster, and
Orals. They received points for organization, quality of research, quality of text and visuals, and quality of
their oral presentation. Top students in each category were recognized at the evening reception held at
Thomson House.
University of Toronto professor John Brummel, who is also co-
director of the Sick Kids Hospital, gave the keynote speech. Brummel
discussed his research on host-pathogen interactions throughout his
career and his efforts to study how exactly pathogens infect host cells.
Brummel, who majored in biochemistry at the University of
Western Ontario, recalls that towards the end of his PhD and postdoc he
was studying bacterial infections and was intrigued by how some
specialized bacteria can take over a macrophage’s signaling network
originally meant to destroy them. As a co-director of the SickKids
MIMM BITES A NEWSLETTER OF McGILL’S MICROBIOLOGY & IMMUNOLOGY DEPARTMENT
JUNE 2015
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Hospital, he now focuses on studying how genes in bacterial infection are altered in humans to
cause inflammatory disorders.
Brummel encouraged students interested in Microbiology and Immunology to become involved
in research as soon as possible in their academic careers.
“The most important thing for undergrad students is to get exposure in a lab as soon as possible,”
Brummel said. “I think once students see the discovery process and actually find something no one else
has found, [they]’ll know if you have the taste for it. And if you do, it’s really an inspiring and motivating
thing to lead you down this career.”
M.Sc. student Jasmin Chahal couldn’t agree more. Chahal finished her undergraduate degree in
MIMM at McGill last April and is now in her first year of the graduate program, striving towards a Ph.D. in
the same department.
Chahal is studying the structural changes in
the genomic RNA of the HCV virus at each stage of
its replication cycle. Ultimately, she said the goal of
her research is to find out if there are inhibitors for
the RNA structure at any stage, so that the whole
cycle of replication can be stopped.
For Chahal, Graduate Student Research
Day is the first of many times she will present her
research.
“This is my first ever conference. It’s a really good idea to do it here because I pretty much know
everyone in the department,” she said. “It’s nice to present to your friends first and get their feedback so
you can improve for other conferences.”
In July, Chahal will be presenting her research at a conference for the American Society of Virology
in London, Ontario.
The Graduate Student Research Day has been planned by students every year for the last four
years. This year the planning was led by third year Ph.D. student Adam Peres, one of five students from
the Microbiology and Immunology Graduate Students Association who were responsible for organizing
the event.
“It’s a good opportunity for all of us graduate students to get together, hear what each other are
doing, enjoy each other’s company and share ideas amongst each other,” Peres said. “It’s really a
celebration of the work we’re doing.”
MIMM BITES A NEWSLETTER OF McGILL’S MICROBIOLOGY & IMMUNOLOGY DEPARTMENT
JUNE 2015
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“The fact that students are organizing it is impressive and also very important because if students
organize it, students will come. I’m glad that you’re doing it and I’d encourage you to keep doing it,”
Brummel said to students.
Department Chair Dr. Joaquin Madrenas agreed. “It basically gives students an opportunity to
start engaging researchers from outside McGill and take responsibility for the organization of the event,
as a preamble for what they will do down the road as faculty members or
researchers on other settings.”
Peres said he found organizing the event to be a rewarding experience.
“I’m really interested in not only doing the lab work, but also the
services associated with academia, so it’s a really cool experience [for me],
learning to coordinate speakers for different events, learning to lead a team of
people, interacting with the guest speaker and all the suppliers. So it’s more
[out of] personal interest, in addition to the lab work I do,” Peres said.
Each poster was judged by a group of three postdoctoral fellows, in
which the department tried to include a microbiologist, an immunologist, and a parasitologist, said
postdoctoral fellow Jenny-Lee Thomassin, who was a judge at the event.
Judge and postdoctoral fellow Thomas Rolain said
that the judging experience exposed him to research in areas
outside of his expertise.
“It was interesting because we have to focus on
[students’] work and try to be interested in what they are
doing even if it’s not [our] field,” Rolain said.
Rolain said that the hardest part of being a judge was to
disregard the fact that he might have known some of the presenters from before. While the department
ensured that the postdocs were not judging anyone who they worked with, they could have been assigned
to a presenter who worked in a lab near them.
“You have to judge them without keeping in mind the fact that you know them outside,” Rolain
said.
Thomassin said that the overall judging experience was challenging. “It was harder to pick a
winner because a lot of the presentations were very good.”
MIMM BITES A NEWSLETTER OF McGILL’S MICROBIOLOGY & IMMUNOLOGY DEPARTMENT
JUNE 2015
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UPCOMING
“[This] is a day to portray the excellent research that is being done by our trainees,” Madrenas
said. “I have been saying all along that the best indicator of how lively a department is, is to look at the
research that is being done by graduate students.”
“If they are engaged in research programs that are exciting and cutting edge, you can rest assured
that the department is doing well. That is the beauty of this day. It shows that we are doing very well in
the department.”
His words rang true at Spring Convocation last Friday, where the Governor General’s Gold Medal,
given to the top graduating Ph.D. student in any discipline, was given to Dr. Francois Coulombe from the
MIMM department.
PhD student Marija Landekic and postdoctoral fellow Mitra Yousefi presenting their research during a
poster session.
CANADIAN SOCIETY OF IMMUNOLOGY To register for the 28th Annual CSI Conference (June 4th to 7th, 2015 in Winnipeg), click here. CANADIAN SOCIETY OF MICROBIOLOGY To register for the annual meeting of the Canadian Society of Microbiology, click here. The meeting is June 15-18 at the University of Regina.
MIMM BITES A NEWSLETTER OF McGILL’S MICROBIOLOGY & IMMUNOLOGY DEPARTMENT
JUNE 2015
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INTERNATIONAL SYMPOSIUM ON HUMAN IMMUNITY AND THE MICROBIOME COMING TO MONTREAL IN 2015. As a result of a partnership between Cell Press (Elsevier) and the CIHR Human Immunology, we are proud to announce the celebration of an International Symposium on Human Immunity and the Microbiome in Health and Disease coming up in September 27-29, 2015. For further information, click here.
SERVICES
Duff Biobar Updates
BioBar Hours The operating hours for the BioBar are the following: between 8-12 and 1-4. Don’t forget the Biobar Stocks Useful Lab Supplies such as: Kleenex; Bleach; Gloves; Paper Towels; Etc.
At competitive price! Please visit our website for the Biobar list of company. For more information, please visit Tom (RM-514, 514-398-3920). If you would like to get a list of products available at the BioBar, please contact Tom Ringer at [email protected].
You are all encouraged to submit any news, grants, papers, awards, pictures, or items that you want to include to our monthly newsletter. We will be happy to share them with the rest of the department. You can email them to Mr Patrick Ritchie.
MIMM BITES A NEWSLETTER OF McGILL’S MICROBIOLOGY & IMMUNOLOGY DEPARTMENT
JUNE 2015
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MIMM BITES A NEWSLETTER OF McGILL’S MICROBIOLOGY & IMMUNOLOGY DEPARTMENT
JUNE 2015
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MIMM BITES A NEWSLETTER OF McGILL’S MICROBIOLOGY & IMMUNOLOGY DEPARTMENT
JUNE 2015
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