COURSE INFORMATON

Course Title Code Semester T+U Hour Credits ECTS

MICROBIAL METABOLISM BTEC 585 1-2 3 + 0 3 8

Prerequisites NONE

Language of Instruction

English

Course Level MSc and PhD Degrees

Course Type Elective

Course Coordinator Prof. Dr. Zeynep Petek ÇAKAR

Instructors Prof. Dr. Zeynep Petek ÇAKAR

Assistants NONE

Internship NONE

Goals

To understand the basic principles of microbial metabolism and

gain insight into systems biology applications of microbial

metabolism, such as metabolic engineering and evolutionary

engineering

Content

Metabolic reactions of microorganisms; microbial energy

metabolism (I): glycolysis and TCA cycle, microbial energy

metabolism (II): respiration, fermentation, regulation of microbial

metabolism, nitrogen metabolism, degradation of organic

compounds, synthesis of cellular products and constituents,

metabolic engineering and evolutionary engineering

Course Learning Outcomes Program Learning Outcomes

Teaching Methods

Assessment Methods

1) Learns basic principles of microbial metabolism and its applications in

metabolic and evolutionary engineering

1,2,3,6,7,8,9 1,2 A,D

2) Learns how to present a scientific research article on microbial metabolism

1,5,10 1,2 C,D

3) Makes a detailed literature survey on a microbial metabolism/metabolic engineering topic of interest

1,2,3,8 1,2 C,D

4) Writes a review article in a scientific format and present it in class

1,2,3,5,6,7,10 1,2 A,C,D

Teaching Methods: 1: Lecture, 2: Question-Answer, 3: Laboratory, 4: Case-study

Assessment Methods:

A: Testing, B: Laboratory, C: Homework, D: Project

COURSE CONTENT

Week Topics Study Materials

1 Metabolic reactions of microorganisms Textbook

2 Microbial energy metabolism (I): Glycolysis and TCA cycle Textbook, journal

articles

3 Microbial energy metabolism (II): respiration, fermentation Textbook, journal

articles

4 Regulation of microbial metabolism Textbook, journal

articles

5 Nitrogen metabolism Textbook, journal

articles

6 Degradation of organic compounds Textbook, journal

articles

7 Synthesis of cellular constituents and products Textbook, journal

articles

8 Metabolic engineering (I) Textbook, journal

articles

9 Metabolic engineering (II) Textbook, journal

articles

10 Evolutionary engineering (I) Textbook, journal articles

11 Evolutionary engineering (II) Textbook, journal articles

12 Review Paper Presentations (I) Textbook, journal

articles

13 Review Paper Presentations (II) Textbook, journal

articles

14 Review Paper Presentations (III) Textbook, journal

articles

RECOMMENDED SOURCES

Textbook Brock Biology of Microorganisms, thirteenth edition, 2011, M.T.

Madigan, J.M.Martinko, Pearson

An introduction to metabolic and cellular engineering, second

edition, 2012, S. Cortassa, M.A. Aon, A.A. Iglesias, J.C. Aon,

D. Lloyd, World Scientific

Any biochemistry textbook (e.g. by Stryer, Zubay, Lehninger

etc.)

Additional Resources recent scientific research articles published in a SCI-cited biotechnology journal.

MATERIAL SHARING

Documents Lecture notes are provided to students.

Assignments

1 research article presentation in class, a review paper (written) assignment on a microbial metabolism/metabolic engineering topic of interest, presentation of that review paper in class at the end of the term.

Exams 1 midterm exam and 1 Final exam

ASSESSMENT

IN-TERM STUDIES NUMBER PERCENTAGE

Mid-terms 1 25

Assignment 1 25

Term Project 1 50

Total 100

CONTRIBUTION OF FINAL EXAMINATION TO OVERALL GRADE

40

CONTRIBUTION OF IN-TERM STUDIES TO OVERALL GRADE

60

Total 100

COURSE CATEGORY Field Courses

COURSE'S CONTRIBUTION TO PROGRAM

No Program Learning Outcomes Contribution Level

1 2 3 4 5

1 Advanced level knowledge of mathematics, statistics, and bioengineering.

x

2 The ability of designing biological systems, analysis or process in order to meet up with the desired requirements/products.

x

3

The ability of identification and describing the engineering problems in biotechnology and bioengineering and proposing solution by making use of most up-to-date techniques and instruments.

x

4

The ability of working efficiently in interdisciplinary teams and being definitive in decision making process by taking responsibilities.

5

The ability of developing efficient communicating skills in the field of biotechnology and presenting oneself efficiently in social and scientific arena/platforms.

x

6

The ability to have occupational ethics and social responsibilities, intellectual conscious in areas of professional conversations, declarations, and applications.

x

7 The ability of perceiving occupational ethics and their implications on the society at legal and economic level.

x

8 The ability of retaining the necessity of lifelong education, learning, and improvement and gain the skills to achieve this.

x

9 The ability of perceiving the impact of bioengineering, genetics, and biotechnology products and solutions at the environmental, global and social levels.

x

10 The ability to express oneself in English orally and in writing at global platform.

x

ECTS ALLOCATED BASED ON STUDENT WORKLOAD BY THE COURSE DESCRIPTION

Activities Quantity Duration (Hour)

Total Workload

(Hour)

Course Duration (Excluding the exam weeks: 14x Total course hours)

14 3 42

Hours for off-the-classroom study (Pre-study, practice) 14 4 56

Mid-term examination 1 5 5

Laboratory - - -

Homework 1 30 30

Project 1 50 50

Final examination 1 6 6

Total Work Load 189

Total Work Load / 25 (h) 7.56

ECTS Credit of the Course 8