Upload
sage-booth
View
26
Download
3
Tags:
Embed Size (px)
DESCRIPTION
Metabolism of Nutrients in Muscle and Adipose Tissue. Anusorn Cherdthong , PhD 137748 Applied Biochemistry in Nutritional Science Email: [email protected] E-learning: http://ags.kku.ac.th/eLearning/137748. Introduction. Protein and lipid are more importance role in muscle and tissue - PowerPoint PPT Presentation
Citation preview
Anusorn Cherdthong, PhD137748 Applied Biochemistry in Nutritional Science
Email: [email protected]: http://ags.kku.ac.th/eLearning/137748
Metabolism of Nutrients in Muscle and Adipose Tissue
IntroductionProtein and lipid are more
importance role in muscle and tissue
Storage and excretion when required
Some metabolism are similar to liver metabolism
Muscle cell---protein storageAdipose tissue---triacylglyceride
storage
Metabolism pathway
In muscle cellProtein synthesisProtein lysis
In adipose tissueTriacylglyceride degradationTriacylglyceride storageLipogenesisControl of fatty acid synthesis
Protein synthesis
Transcription: messenger RNA (mRNA), ribosomal RNA (rRNA), transfer RNA (tRNA) and small nuclear RNA (snRNA)
InitiationElongationTermination
TranslationInitiationElongationTermination
Protein lysis
Required proteinasesLower rate than liver—low proteinases proteinases enzymes
cathepsin D alkaline proteinases: Ca2+-activated proteinase or –factor (CAF)
Low protein lysislow protein synthesisStress---high protein lysis
Lipid metabolism
Occurred at adipocyte of adipose tissueControl—triacylglyceride, free FAProvide various substances--- adipokineInduce by hungry, diets, digestion/absorption system, hormone, CNS etc
Triacylglyceride degradation
Control by hormone systemEnd products are FA and glycerolFA—oxidation---energy (95%)5% energy from glycerol
Triacylglyceride storage
Increase after feedingLDL synthesis at adipose—induce by insulin
glycolytic enzyme phosphofructokinase-1---.>fructose 2,6-bisphosphate
Fatty acyl CoA + glycerol-3-phosphate-triacylglycerol
Insulin induce glucose -FA
Lipogenesis
In ruminant occurred 92% in adipose tissue
Substrate: C2 and C4Energy from NADPH, ATP NADPH—isocitrate and oxaloacetate
In non ruminant occurred in liverSubstrate: glucoseNADPH---pentose shunt --malate dehydrogenase
Control of fatty acid synthesis
Hormone controlledInsulin: induce FA synthesis
Transfer glucose into cellActivated pyruvate dehydrogenase
Enzyme:acetyl-CoA carboxylase acitvate by citrate
NADPH
Conclusion
1
2
Protein and lipid are major metabolism
Muscle storage protein while adipose was storage tryacylglyceride
3 Protein metabolism: RNA transcription, translation
4 Triacylglycerols metabolism was differ among specie animals