The DrugSmith is The Monthly Newsletter of The Smith Drug Company A Division of J M Smith Corporation

Spartanburg, SC • Paragould, AR • Valdosta, GA

Men's Health MonthCataract Awareness Month

Statin Use In Diabetes • Continuing EducationStops The Sting • Russell Stover Ordering Change

Smith Drug Company will be closedMonday, July 4th, in observance of

Independence Day. Please order accordingly!

Statin Use In DiabetesThe literature support for the benefits of statins has grown since their introduction to the market in 1987.

By: Larry Kobiska, RPh, BS, PharmD, Senior Director Professional Pharmacy Service, Smith Drug Company

Numerous trials have proven the reduction of morbidity and mortality in patients with heart disease. Additionally, the benefits of the use of statins in patients with Type 2 Diabetes has been demonstrated in numerous trials encompassing thousands of patients.

Both the American Diabetes Association (ADA) Standard of Medical Care in Diabetes and the American College of Cardiology/American Heart Association (ACC/AHA) Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults recommend the use of statins in Type 2 Diabetes for the reduction of morbidity and mortality. Both groups recommend the use of statins in patients aged 40-75 years with Type 2 Diabetes for the primary prevention of atherosclerotic cardiovascular disease (ASCVD).

Meta-analysis from 14 randomized trials including more than 18,000 patients with Type 2 diabetes, demonstrated a 9% proportional reduction in all-cause mortality and a 13% reduction in vascular mortality for each 39mg/dl reduction in LDL cholesterol.

Three random controlled trials for the primary prevention of ASCVD are cited by the ACC/AHA guideline. In patients 40-75 years of age, with LDL-C 70-189 mg/dl, and an estimated 10 year risk of ASCVD of greater than or equal to 7.5%, a high level of risk reduction was found.

As Type 2 diabetes in and of itself increases the risk for ASCVD, the ADA guideline suggests that calculating the 10 year risk of ASCVD may have limited use in patients with Type 2 diabetes. The ADA guideline recommends the use of a statin in all patients with Type 2 Diabetes, regardless of LDL-C level. One may reason that considering the high proportion of dyslipidemia in patients with Type 2 diabetes, most patients would likely have an LDL-C level greater than 70mg/dl.

In Type 2 diabetic patients greater than 75 years of age and no other risk factors, there is limited data in the primary prevention of ASCVD. However, statin therapy for other risk factors or for secondary prevention remains recommended.

For patients 40-75 years of age with no other risk factors, moderate intensity statin therapy should be initiated. For those with risk factors, high intensity statin therapy should be initiated. See the charts on the following page.

Secondary to this compelling evidence, statin use in patients with diabetes is a quality measure for 5-Star Ratings. Pharmacist intervention for these patients provides a large opportunity to increase the quality of care for patients with Type 2 diabetes by decreasing both morbidity and mortality.

2

Reference: 2016 American Diabetes Association (ADA) Standard of Medical Care in Diabetes, Diabetes Care Vol 39, Sup 1, Jan 2016

3

Table 8.1 Recommendations for Statin and

Combination Treatment in People with Diabetes

Table 8.2 High-Intensity and Moderate-Intensity Statin Therapy

Reference: 2016 American Diabetes Association (ADA) Standard of Medical Care in Diabetes, Diabetes Care Vol 39, Sup 1, Jan 2016

Reference: 2016 American Diabetes Association (ADA) Standard of Medical Care in Diabetes, Diabetes Care Vol 39, Sup 1, Jan 2016

*In addition to lifestyle therapy. **ASCVD risk factors include LDL cholesterol >=100 mg/dL (2.6 mmol/L), high blood pressure, smoking, overweight and obesity, and family history of premature ASCVD.

Age Risk Factors Recommended Statin Intensity

<40 YearsNoneASCVD risk factor(s)**ASCVD

NoneModerate or highHigh

40-75 Years

NoneASCVD risk factorsASCVDACS and LDL cholesterol >50mg/dl in patients who cannot tolerate high dose statins

ModerateHighHighModerate plus ezetimibe

>75

NoneASCVD risk factorsASCVDACS and LDL cholesterol >50mg/dl in patients who cannot tolerate high dose statins

ModerateModerate or HighHighModerate plus ezetimibe

High-intensity statin therapy(Lowers LDL cholesterol >= 50%)

Moderate-intensity statin therapy(Lowers LDL cholesterol 30%-50%)

Atorvastatin 40-80mg dailyRosuvastatin 20-40mg daily

Atorvastatin 10-20mg dailyRosuvastatin 5-10mg dailySimvastatin 20-40mg dailyPravastatin 40-80mg dailyLovastatin 40mg dailyFluvastatin XL 80mg dailyPitavastatin 2-4mg daily

Needles are sold separately and may require a prescription in some states. Needles and FlexTouch® are for single patient use only.

FlexTouch® and Tresiba® are registered trademarks of Novo Nordisk A/S. Novo Nordisk is a registered trademark of Novo Nordisk A/S. TRICARE® is a registered trademark of the Department of Defense (DoD), DHA.© 2016 Novo Nordisk All rights reserved. USA16TSM00594 April 2016

Tresiba® U-200 FlexTouch®—2 to 160 units in a single injection (in 2-unit increments)

U-100 Also available in Tresiba® U-100 FlexTouch®—Maximum dose of 80 units per injection (in 1-unit increments)

76 For both the Tresiba® U-100 and U-200 FlexTouch® pens, the dose window shows the number of units to be delivered

Tresiba® FlexTouch® has no push-button extension, regardless of dose

PAY

NO MORE THAN

PER PRESCRIPTION

$15 With the Tresiba® Instant Savings Card, eligible patients can pay no more than $15 per Tresiba® prescriptiona

– Patients can apply either by going online to Tresiba.com or by calling 1-855-834-3466. Patients should activate the card before filling their prescription

a Eligibility and other restrictions apply. Offer valid for select Novo Nordisk products. Offer not valid for patients enrolled in any government, state, or federally funded medical or prescription benefit program, including Medicare, Medicaid, VA, DoD, and TRICARE®. The federal employee health benefits program is not a federal or state government health care program for purposes of this savings program. Offer is valid for a maximum benefit of $500/month. Card is valid for up to 24 prescriptions. Complete details are provided with the card.

Explore additional Tresiba® support resources at TresibaPro.com

ON THE INSIDE

Healthwise™ Clinical SolutionsHealthwise™ Circular Program

DollarWise™ ProgramGood Sense® Controlled Label Program

Greeting Cards ProgramContinuing EducationGift and Trade Show

Rx QuickShip™

Third Party StationPharmacy First

DrugSmith™ Monthly NewsletterSmith Weekly e-BlastDiabeticare Program

Hamacher Retail Zone PricingHome Health Care Catalog

HealthWise Signage ProgramSmith Gift Box Gift Category

Vials and Vitamin ProgramDirect Mail Advertising

Well Staffed Customer ServiceExcellent Service LevelsStore Fixture Program

Merchandising ServicesSpotlight Program

Repeat Rewards Loyalty Cards

Statin Use in Diabetes 2Men's Health Month: Get Screened 6Men's Health Facts 82016 Continuing Education Curriculum 9Cataract FAQs 10Pharmacy Solutions: Drug Name Change 11Russell Stover Ordering Procedure Change 11New Product: Stops The Sting™ 12The Smith Drug CE/Gift & Trade Show 15

The Entire

family would like to take this opportunity to congratulate

on his recent retirement, after 25 years of service.

We wish you peace and enjoymentfor years to come!

RANDY LAWTER

6

IT'S ALWAYS TIME FOR ROUTINE SCREENING.The Importance of Routine Screening:

It is important to diagnose a health issue before it starts or when it is at its initial stage. One has to take the right treatment at the right time that helps to increase the chances of a long and healthy life. In this regard, health screenings can give you a proper report of your health status.

Important exams and screening for men’s health:

Traditionally, men are not concerned with their health issues and remain less interested in routine health checkups. But the fact is, men die earlier than women, as their life expectancy is lower than women. Cancer rates are found more in men compared to women, and many other men’s health issues are also on the same page. So, here we discuss about six necessary screenings for men’s health that include:

Blood Pressure Test:

The body’s strength applies by the heart to drive blood throughout your body, a function denoted by the blood pressure. If your blood pressure reading comes 120/80 then it’s normal and you are healthy but, if the reading consistently comes 140/ 90 i.e. you have high blood pressure, then there is always a risk of heart attack, stroke and also kidney diseases. During low blood pressure, you feel dizziness, fainting and lightheadedness.

A blood pressure test is very simple and quick. You can even check it at your home. In case you find any sign of doubt then consult your doctor, he can prescribe you medicines or suggest changing your lifestyle. Some particular practices like losing weight, change in eating habits, exercising, etc. are highly recommended to control blood pressure.

Cholesterol Test:

Cholesterol is a fat found in the blood. It is good as well as bad. Low-Density Lipoprotein (LDL) is the bad cholesterol and unhealthy for you, while High-Density Lipoprotein (HDL) is the good cholesterol. According to medical science, 200 mg per dL is perfect. But, the range of cholesterol is below 100 mg per dL and above 240 mg per dL indicates a risk to men’s health. High levels of cholesterol cause heart attack and stroke. The amount of cholesterol is checked by the blood test. Before the test you can't drink or eat anything for approx 9 hours, to ensure accurate results.

Prostate Cancer Screening:

This type of cancer grows in the gland in the male reproductive system; this disease only affects men. As per the research, 80% of men in their eighties are affected by a symptom of prostate cancer. The primary symptoms of this disease are:

• Painful urination• Painful ejaculation• Frequent Urination• Difficulty in achieving erection• Leg weakness• Spine, pelvis or ribs can be painful

A screening of prostate once in two years is beneficial to know its status if any. Doctors do two exams, first is prostate specific antigen (PSA) test which shows four nanograms /milliliter for healthy men and, second, is Digital Rectal Exam in which a doctor physically checks your rectum for cancer signs. Prostate Cancer is one of the major men’s health issues. It requires a lot of preventions and changes in daily lives. Doctors may suggest you to go for vegetables and fruits, meditation, yoga and regular exercise beside some medicines.

Colon Cancer Screening:

This cancer begins in the colon or rectal. Colon cancer is also known as colorectal cancer, which grows when healthy cells get damaged in the colon and continuously divide into cancerous cells and demolish normal tissue.Colonoscopy method is used to diagnose the whole colon and rectum. Virtual colonoscopy is also done in which CT scan images show a clear inside view of the colon. To reduce the risk of colon cancer, doctors suggest:

• High intake of vegetables, fruits and whole grains• Avoid smoking• Avoid alcohol or take in moderate amounts• Do more exercise• Maintain a healthy weight

Skin Cancer Check:

Men’s skin is three times more influenced by the risk of skin cancer than women’s. Major types of skin cancers are basal, squamous and melanoma. There are some skin tests to check the presence of any possible skin problem. Skin cancer can be prevented by less exposure to sunlight, so you have to cover your body with clothes and use sunscreen protection before going out.

Diabetes Test:

Diabetes is caused due to increased level of sugar in the blood. To diagnose the blood sugar, doctors suggest some blood tests, such as:

• A1C testIf it is less than 5.7%, then it’s normal, and 6.5% shows diabetes.

• FPG (Fasting Plasma Glucose test)Less than 100 mg/dl means healthy and at least 126 mg/dl means diabetes.

• OGTT (Oral Glucose Tolerance test)Less than 140 mg/dl indicates normal and at least 200 mg/dl indicates diabetes.

Get Involved:

As a Healthwise Community Pharmacy, this is a golden opportunity to talk to your male customers either directly, or through their spouses, mothers or siblings. If you offer BP testing, you're ahead of the game. If not, pass this knowledge on as your own, and gain the confidence, trust and value, that all health conscious people are looking for in a pharmacist.

You can also get involved by participating and promoting WearBlueDay on June 17. Find out how you can get involved by visiting www.menshealthmonth.org.

Source: menshealth.org

7

AWARENESS. PREVENTION. EDUCATION. FAMILY.

June is Men’s Health Month

1994

88.91 in 2

100%

01 02 03

Women are 100% more likely than men to visit the doctor for annual exams and preventative services.

1 in 2 men are diagnosed with cancer in their lifetime compared

with 1 in 3 women.

On May 31, 1994 President Bill Clinton signed the bill establishing

National Men’s Health Week.

In 2010, there were 88.9 men for every 100 women in the

age group 65-69.

Men’s Health MonthMensHealthMonth.org

Men’s Health NetworkMensHealthNetwork.org

Get It CheckedGetItChecked.com

Talking About Men’s Health Blog TalkingAboutMensHealth.com

Men’s Health Resource CenterMensHealthResourceCenter.com

“Recognizing and preventing men’s health problems is not just a man’s issue. Because of its impact on wives, mothers, daughters, and sisters, men’s health is truly a family issue.” — Congressman Bill Richardson (May 1994)

ONLINE RESOURCES

MensHealthMonth MensHealthMonth MHW@menshealthweek.org

Eat Healthy. Start by taking small steps like saying no to super-sizing and yes to a healthy breakfast. Eat many different types of foods to get all the vitamins and minerals you need. Add at least one fruit and vegetable to every meal.

Get Moving. Play with your kids or grandkids. Take the stairs instead of the elevator. Do yard work. Play a sport. Keep comfortable walking shoes handy at work and in the car. Most importantly, choose activities that you enjoy to stay motivated.

Make Prevention a Priority.Many health conditions can be detected early with regular checkups from your healthcare provider. Regular screenings may include blood pressure, cholesteral, glucose, prostate health and more.

8AWARENESS • PREVENTION • EDUCATION • FAMILY

MENSHEALTHMONTH

The Smith Drug Company 12TH Annual CE/Gift & Trade Show • July 15-17

Friday, 7/15/2016 • Managing COPD• Developing a Medication Synchronization and Monitoring Program • Preventing Chronic Diabetes Complications (not approved for Pharmacy Techs).

Saturday, 7/16/2016• MTM Program in Diabetes• SDC/DEA sponsored program on being “Gate Keeper of Drugs”

NOTE: There will be a special presentation made by Diplomat on opportunities for today’s pharmacy on Specialty drugs. You don’t want to miss this! Learn how you can become a Specialty Pharmacy and “Move Forward” by keeping in touch with the latest practices in pharmacy. (At time of print not determined whether it is CE approved.)

Sunday, 7/17/2016• Prevention of Opioid Overdose/HIV• Immunization Updates• Law Class• Appointment Based Model Pharmacy

All Classes are ACPE approved except for the luncheon on Friday and the presentation by Diplomat on Saturday.

[Tentative schedule and subjects to be covered. More information to follow.]

Be sure to join us at breakfast and lunch breaks for Smith Management and clinical pharmacy services experts keeping you informed on turn-key pharmacy solutions.

We look forward to seeing you there!

9

GET A HEAD START ON COLD & FLU SEASON!

COMING IN JULY 2016!

Who is at risk?

Older people are generally more at risk of developing cataracts than younger people. Approximately 60% of people ages 60 and older have their vision significantly affected by cataract formation. For people over age 55, cataracts are the leading cause of vision loss.

Diabetes, heredity, eye trauma and certain medications can accelerate cataract development, and there is some evidence that smoking can also accelerate cataract development.

How is a cataract diagnosed?

Cataracts are usually detected during an examination by a qualified ophthalmologist. Eye Surgical Associates has many ophthalmologists qualified to diagnose cataracts. Regular appointments are important for early detection of cataracts. Some of the standard eye tests that may be used to diagnose cataracts include:

• Visual acuity test - A chart is used to evaluate how well the patient sees at multiple distances.

• Pupil dilation - Eye drops widen the pupil so that the lens and retina can be better examined.

• Tonometry - Fluid pressure in the eye is gauged in this exam, which also helps detect glaucoma.

How effective is cataract surgery?

According to the American Society of Cataract and Refractive Surgery (ASCRS), 98% of cataract surgeries are considered successful. Risk is even lower in patients who undergo the advanced procedures available from Eye Surgical Associates, both of which leave the eye’s capsule intact. Most patients report improved vision and few complications.

In developed countries like the United States, cataract blindness is rare because treatment is accessible. However in developing countries, where medical treatment may be difficult to obtain, cataracts often lead to blindness. In fact, 51% of global blindness - mostly in the developing world - are due to untreated cataracts.

FAQ's

What happens after surgery?

Recovery time after cataract surgery is usually about six weeks, but most discomfort should subside after a day or two. Immediately following surgery, the patient may experience some pain and irritation of the eye. Many patients also experience increased light sensitivity and a small amount of fluid discharge. Special pills and eye drops may be prescribed to promote healing and regulate the pressure inside the eye. Pain relievers may also be taken during the first few days if necessary. Follow-up exams allow the physician to monitor patient progress. Sunglasses or eye shields can help protect the eye while it is healing.

What is the chance of having normal vision again?

After surgery, there will be a period of recovery while the eyes adjust to seeing without the cataract. If only one eye is treated, the eyes must learn to work together again. Many everyday activities can be resumed soon after surgery, although patients may experience blurry vision for a time. Driving may be impractical and unsafe at first; your physician will advise you on the appropriate time to begin driving again. Also, patients who receive intraocular lenses (IOLs) may notice some color distortion at first. This should resolve itself within a few months, as the eyes adjust to the new, clear lenses of the IOLs.

Most people will still require reading glasses, bifocals or contacts after cataract surgery, despite the improvement in vision that the procedure offers. However, Eye Surgical Associates is proud to offer a new generation of Advanced Lenses that can significantly reduce or even eliminate the need for reading glasses.

10

Brintellix (vortioxetine) Renamed Trintellix (vortioxetine) in U.S. to Avoid Name Confusion

Deerfield, Ill., and Osaka, Japan (May 2, 2016) – Takeda Pharmaceuticals U.S.A., Inc., a wholly-owned subsidiary of Takeda Pharmaceutical Company Limited (TSE:4502) (collectively “Takeda”), and Lundbeck announced today that Brintellix (vortioxetine) will be marketed in the United States under the new name Trintellix (vortioxetine) starting in June of 2016. The vortioxetine product is a prescription medicine approved to treat Major Depressive Disorder (MDD) in adults. The formulation, indication and dosages of Trintellix remain the same as that of Brintellix.

This name change comes after receiving reports of name confusion in the marketplace between Brintellix and the anti-blood clotting therapy Brilinta® (ticagrelor). In response, Takeda and Lundbeck, in coordination with the U.S. Food and Drug Administration (FDA), determined that a name change would be the best way to minimize future product name confusion by patients and providers.

“Though the original name was fully screened prior to launch, after learning about name confusion issues with Brintellix and Brilinta, we quickly took action to educate healthcare professionals and pharmacies about the potential for name confusion,” said Thomas Harris, Vice President Global Regulatory Affairs at Takeda. “Takeda and Lundbeck then proactively worked with the FDA and decided to change the name of our product as we believe this action will help minimize future risk of patients inadvertently receiving the incorrect medication.”

“Even though the name of the product is changing, together with Takeda, we will work to ensure providers and patients are aware that the vortioxetine product itself has not changed. It’s still the same medication, dosing and expected outcomes,” said Gregg Pratt, Vice President, U.S. Regulatory Affairs at Lundbeck.

“Patient safety is our utmost priority at Takeda and Lundbeck,” said Ramona Sequeira, President, U.S. Business Unit at Takeda. “Together, with our partners at Lundbeck, we will initiate a robust communication campaign and actively work to ensure that patients, healthcare professionals and pharmacies have uninterrupted access to this important medication. We believe these actions speak to our goals of building our business around patients, trust and reputation.”

During the transition period this summer, healthcare providers can still prescribe, and patients will still have access to, the product under its current brand name. The newly named Trintellix will be available in June 2016. Additionally, markings on the Trintellix tablets will be identical to the markings on tablets prior to the name change. Trintellix will have new National Drug Code (NDC) numbers associated with the product. Individuals and healthcare professionals who have questions about Brintellix, Trintellix and/or the name change, should contact Takeda at 1-877-TAKEDA-7.Errors involving Brintellix/Trintellix or any other products should be reported to the FDA MedWatch program online at www.fda.gov/medwatch.

MAKING PHARMACY NEWS New Seasonal CandyORDERING PROCEDURE

Please make note, that beginning with the Halloween Seasonal candy catalog that you will be receiving, all seasonal candy will be following

this new procedure:

This new ordering procedure is only applicable to seasonal candy. Russell

Stover everyday candy is not affected.

• All orders will be pre-booked and shipped to you one time, each individual holiday season.

• Pre-book orders for Halloween must be returned by June 15, 2016.

• Fax your orders to 800.831.1216

• There are no returns for candy orders.

• Please place one order for the entire applicable holiday season.

11

12

Insect stings and bites are both painful and irritating, but there’s a new product that quickly

helps with that problem.

“Stops the Sting™!” is a soothing ointment that neutralizes toxins from insect bites and stings. It is not a scrub or ammonia based product and is

safe for all ages.

Stops the Sting™ can help treat the pain and blistering of fire ant stings, as well as the pain of

bee, wasp and jellyfish stings. It also stops the itching and swelling of mosquito bites.

When using Stops the Sting™, simply remove the stinger if necessary, and apply directly on the bite or sting, then rub gently. Re-apply as

necessary.

The active ingredient in Stops the Sting™ is colloidal oatmeal. Inactive ingredients include Kaolin, Triethanolamine, Diethanolamine and

water.

Easy to use and convenient to carry. Pack Stops the Sting!™ in your handbag,

first aid kit, glove compartment, golf bag or the family camping gear.

Get fast, complete relief from the pain, itching

and swelling from insect bites and stings with Stops the Sting!™

Doctor Recommended!

Fast Relief from:

Insect Bites and Stings

Wasps

Hornets

Bees

Fire Ants

JellyfishSmith # 628792

EpiPen®, EpiPen Jr®, EpiPen 2-Pak®, EpiPen Jr 2-Pak® and LIFE HAPPENS. Be Prepared.® are registered trademarks owned by the Mylan companies. © 2016 Mylan Specialty L.P. All rights reserved. 2/16 EPI-2016-0026

being prepared means having a plan to:• Avoid known allergens

• Know what symptoms to watch for

• Use an EpiPen® (epinephrine injection) Auto-Injector

if a life-threatening (severe) allergic reaction occurs

• Get emergency medical help right away

have epipen® auto-injectors wherever you may need them Family vacations can be full of surprises, so have

access to two EpiPen® Auto-Injectors wherever you go.

Why two? Because 1 in 5 people will need a second

dose of epinephrine to treat a severe reaction. If a third

dose is required for a single episode, it should be

administered only under direct medical supervision.

important safety informationEpiPen® (epinephrine injection) 0.3 mg and EpiPen Jr® (epinephrine injection) 0.15 mg Auto-Injectors contain a single dose of epinephrine, which you (or your caregiver or others who may be in a position to administer EpiPen® or EpiPen Jr®) inject into the middle of your outer thigh (upper leg) (through clothing, if necessary). Get emergency medical help right away. You may need further medical attention. Only a healthcare professional should give additional doses of epinephrine if you need more than two injections for a single anaphylactic episode. DO NOT INJECT INTO YOUR VEINS, BUTTOCKS, FINGERS, TOES, HANDS OR FEET. In case of accidental injection, please seek immediate medical treatment. Epinephrine should be used with caution if you have heart disease or are taking certain medicines that can cause heart-related (cardiac) symptoms.Tell your doctor if you have certain medical conditions such as asthma, depression, thyroid disease, Parkinson’s disease, diabetes, high blood pressure or heart disease, have any other medical conditions, are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed. Be sure to also tell your doctor all the medicines you take, especially medicines for asthma. If you have certain medical conditions, or take certain medicines, your condition may get worse or you may have longer lasting side effects when you use EpiPen® or EpiPen Jr®.

The most common side effects may include increase in heart rate, stronger or irregular heartbeat, sweating, nausea or vomiting, difficulty breathing, paleness, dizziness, weakness,

important safety information (continued) shakiness, headache, apprehension, nervousness or anxiety. These side effects may go away if you rest. Tell your healthcare professional if you have any side effect that bothers you or that does not go away.

indications EpiPen® and EpiPen Jr® Auto-Injectors are for the emergency treatment of life-threatening allergic reactions (anaphylaxis) caused by allergens, exercise, or unknown triggers; and for people who are at increased risk for these reactions. EpiPen® and EpiPen Jr® are intended for immediate administration as emergency supportive therapy only. Seek immediate emergency medical help right away.You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088. For additional information, please contact us at 800-395-3376.Please see Brief Summary of full Prescribing Information on the adjacent page.

VACATIONS HAPPEN.

Be Prepared.

Remember to keep your EpiPen® Auto-Injectors at room temperature (68° to 77°F). They should not be stored in extreme heat or cold.

Pay as little as $0* every time you fill your EpiPen® Auto-Injector prescription with our savings card. Download your card at epipencoupon.com

* Eligibility Terms and Restrictions apply. See full Terms and Conditions at epipencoupon.com.

BRIEF SUMMARY OF PATIENT INFORMATIONPlease read this information before using EpiPen® or EpiPen Jr® Auto-Injector and each time you get a refill. Consult the Patient Information and Instructions for Use. You, your parent, a caregiver or others who may be in a position to administer EpiPen® or EpiPen Jr® Auto-Injector, should know how to use it before you have an allergic emergency.This information does not take the place of talking with your health care professional about your medical condition or your treatment. If you have any questions, ask your health care professional.What is the most important information I should know about the EpiPen® and EpiPen Jr®?1. EpiPen® and EpiPen Jr® contain

a medicine used to treat allergic emergencies (anaphylaxis). Anaphylaxis can be life-threatening, can happen within minutes, and can be caused by stinging and biting insects, allergy injections, foods, medicines, exercise, or unknown causes. Symptoms of anaphylaxis may include:

• trouble breathing • wheezing • hoarseness (changes in the way

your voice sounds) • hives (raised reddened rash

that may itch) • severe itching • swelling of your face, lips, mouth,

or tongue • skin rash, redness, or swelling • fast heartbeat • weak pulse • feeling very anxious • confusion • stomach pain • losing control of urine or bowel

movements (incontinence) • diarrhea or stomach cramps • dizziness, fainting, or “passing out”

(unconsciousness)2. Always carry your EpiPen® or

EpiPen Jr® with you because you may not know when anaphylaxis may happen.

Talk to your health care professional if you need additional units to keep at work, school or other locations. Tell your family members, caregivers and others where you keep your EpiPen® or EpiPen Jr® and how to use it before you need it. You may be unable to speak in an allergic emergency.3. When you have an allergic emergency

(anaphylaxis):• Use EpiPen® or EpiPen Jr® right away.• Get emergency medical help right away.

You may need further medical attention. You may need to use a second EpiPen® or EpiPen Jr® if symptoms continue or recur. Only a health care professional should give additional doses of epinephrine if you need more than 2 injections for a single anaphylaxis episode.

What are EpiPen® and EpiPen Jr®?• EpiPen® and EpiPen Jr® are disposable,

prefilled automatic injection devices (auto-injectors) used to treat life-threatening, allergic emergencies including anaphylaxis in people who are at risk for or have a history of serious allergic emergencies. Each device contains a single dose of epinephrine.

• EpiPen® and EpiPen Jr® are for immediate self (or caregiver) administration and do not take the place of emergency medical care. You should get emergency help right away after using EpiPen® and EpiPen Jr®.

• EpiPen® and EpiPen Jr® are for people who have been prescribed this medicine by their health care professional.

• The EpiPen® Auto-Injector (0.3 mg) is for patients who weigh 66 pounds or more (30 kilograms or more).

• The EpiPen Jr® Auto-Injector (0.15 mg) is for patients who weigh about 33 to 66 pounds (15 to 30 kilograms).

• It is not known if EpiPen® and EpiPen Jr® are safe and effective in children who weigh less than 33 pounds (15 kilograms).

What should I tell my health care professional before using the EpiPen® or EpiPen Jr®?Before you use EpiPen® or EpiPen Jr®, tell your health care professional about all your medical conditions, but especially if you: • have heart problems or high

blood pressure • have diabetes • have thyroid problems • have asthma • have a history of depression • have Parkinson’s disease • have any other medical conditions • are pregnant or plan to become

pregnant. It is not known if epinephrine will harm your unborn baby.

• are breastfeeding or plan to breastfeed. It is not known if epinephrine passes into your breast milk.

Tell your health care professional about all the medicines you take including prescription and over-the-counter medicines, vitamins and herbal supplements. Tell your health care professional of all known allergies.Especially tell your health care professional if you take certain asthma medicines. EpiPen® or EpiPen Jr® and other medicines may affect each other, causing side effects. EpiPen® or EpiPen Jr® may affect the way other medicines work, and other medicines may affect how EpiPen® or EpiPen Jr® works.Use your EpiPen® or EpiPen Jr® for treatment of anaphylaxis as prescribed by your health care professional, regardless of your medical conditions or the medicines you take.What are the possible side effects of the EpiPen® and EpiPen Jr®?EpiPen® and EpiPen Jr® may cause serious side effects.• The EpiPen® or EpiPen Jr® should only

be injected into the middle of your outer thigh (upper leg). Do not inject the EpiPen® or EpiPen Jr® into your:

• veins • buttocks • fingers, toes, hands, or feetIf you accidentally inject EpiPen® or EpiPen Jr® into any other part of your body, go to the nearest emergency room right away. Tell the health care professional where on your body you received the accidental injection.If you have certain medical conditions, or take certain medicines, your condition may get worse or you may have longer lasting side effects when you use your EpiPen® or EpiPen Jr®. Talk to your health care professional about all your medical conditions.Common side effects of EpiPen® and EpiPen Jr® include: • fast, irregular or “pounding” heartbeat • sweating • headache • weakness • shakiness • paleness • feelings of over excitement,

nervousness or anxiety • dizziness • nausea or vomiting • breathing problemsThese side effects may go away with rest. Tell your health care professional if you have any side effect that bothers you or that does not go away.These are not all the possible side effects of the EpiPen® or EpiPen Jr®. For more information, ask your health care professional or pharmacist.Call your health care professional for medical advice about side effects. General information about the safe and effective use of EpiPen® and EpiPen Jr®:Medicines are sometimes prescribed for purposes other than those listed in a Patient Information Leaflet. Do not use the EpiPen® or EpiPen Jr® for a condition for which it was not prescribed. Do not give your EpiPen® or EpiPen Jr® to other people.

Important Information• If an accidental injection happens,

get medical help right away.

Manufactured for Mylan Specialty L.P., Morgantown, WV 26505, U.S.A. by Meridian Medical Technologies, Inc., Columbia, MD 21046, U.S.A., a Pfizer company.EpiPen® and EpiPen Jr® are registered trademarks owned by the Mylan companies.© 2015 Mylan Specialty L.P. All rights reserved.10/15 EPI-2015-0811

15

an event rich in tradition

THE SMI TH DRUG COMPANY12th ANNUAL

CONT INUING EDUCAT ION & GIFT AND TRADE SHOW

JULY 15-17, 2016

PRICING EVEN T MENU OPT IONS

ACCOMMODAT IONS

The westin Savannah harbor • Savannah,GA

The Continuing Education & Gift and Trade Show is an a la carte menu to select from:

Your pharmacy will be invoiced for your CE/Trade Show registration approximately two (2) weeks prior to the event date.

DEADLINE TO REGISTER IS: June 13, 2016

ContinuingEducation $120

One time fee for all available CE hours - each individual planning to attend CE MUST fill out a separate registration form – you CANNOT have a guest listed that plans to attend CE; i.e. if you and your spouse are both pharmacists and both plan on taking advantage of the CE hours made available at this time you will EACH need to fill out a registration form individually.

Trade Show $50 Per person over the age of 18, this includes your guest(s). If they plan to walk the trade show floor with you the fee will need to be applied to that individual.

Dinner $75The President/Owner (and their guest) of each pharmacy will receive a complimentary meal for Saturday night’s (7/16/16) Customer Appreciation Dinner; all other registrants and guests from the same pharmacy (if they choose to attend the dinner) will have the dinner fee applied.

Room Rate:Westin Savannah Harbor

$209 Nightly

Plus Resort Fees.

If your participation in the CE/Trade Show requires an overnight stay, room booking is separate from the registration process. Please call (912) 201-2000 which will connect you directly to the Westin Savannah Harbor. To receive this special rate, please make sure you identify yourself as part of the Smith Drug Company room block. Special room rate expires: 6.13.16.

REGIST ER ONLINE: H T TPS://WWW.REGONLINE.COM/SDCCE TS-2016

an event rich in tradition

THE SMI TH DRUG COMPANY12th ANNUAL

CONT INUING EDUCAT ION &GIF T AND TRADE SHOW

REGIST ER ONLINE H T TPS://WWW.REGONLINE.COM/SDCCE TS-2016

JULY 15-17, 2016

The WESTIN savannah harborSavannah,GA