Medical technology industry

Table of ContentsMedical technology industry

Overview07 Total medtech revenue worldwide 2009-2022

08 Total medtech growth per year worldwide 2010-2022

09 Expenditure on research and development in global medtech 2009-2022

10 R&D spending as percent of medtech revenue worldwide 2009-2022

11 Growth rate in research and development spending in global medtech 2010-2022

12 U.S. and European medical technology companies - total revenues 2009-2016

13 Number of medtech companies worldwide 2013-2015, by revenue range

Companies15 Medical technology - top 10 companies based on revenue 2016

16 Revenue of Johnson & Johnson's medical devices and diagnostics by franchise 2011-2016

17 Medtronic's total revenue 2006-2017

18 General Electric revenue in the Healthcare segment 2008-2016

19 Revenue of Fresenius 2008-2016

20 Medical technology revenue of Siemens 2004-2017

21 Market capitalization growth of top large medtech companies worldwide 2016

22 Market capitalization growth of small medtech companies worldwide 2016

23 Predicted top medical technology companies by revenue 2022

24 Global medical technology R&D spending share in top companies 2016 and 2022

Segments26 Global medtech market share by segment 2016 and 2022

27 Global in vitro diagnostics market share by top medtech companies 2016 and 2022

28 Global cardiology market share by top 10 medtech companies 2016 and 2022

29 Global diagnostic imaging market shares of top medtech companies 2016 and 2022

30 Global orthopedics market share - top medtech companies 2016 and 2022

31 Global ophthalmics market share of top medtech companies 2016-2022

IPOs, M&As, funding33 Medtech IPOs before and after the financial crisis as of 2017

34 Selected major medtech IPOs in the U.S. and Europe by proceeds 2016-2017

35 Number of M&A deals in medical technology worldwide 2007-2016

36 Value of M&A medical technology company deals worldwide 2007-2016

37 Top medtech mergers and acquisitions by value 2016-2017

38 Medtech venture capital investment - U.S. and Europe 2006-2017

Costs and utilization40 Average price of a MRI by country 2014

41 Average cost of hospital and physicians for hip replacements by country 2014

42 Average cost of hospital and physicians for bypass surgery by country 2014

43 MRI units per million: by country 2016

44 MRI scanner - number of examinations in selected countries 2015

45 Computer tomography (CT) - number of examinations in selected countries 2015

46 Number of knee replacements in OECD-countries 2015

OverviewMedical technology industry

Overview

Further information regarding this statistic can be found on page 48.

7

Total global medical technology revenue from 2009 to 2022 (in billion U.S. dollars)

Total medtech revenue worldwide 2009-2022

Note: Worldwide; 2009 to 2017

Source: Evaluate ID 325809

Rev

enue

in b

illio

n U

.S. d

olla

rs

2009 2010 2011 2012 2013 2014 2015 2016 2017* 2018* 2019* 2020* 2021* 2022*0

100

200

300

400

500

600

308326

352 362 369 379 371387

403425

449473

497522

data

Overview

Further information regarding this statistic can be found on page 49.

8

Total global medical technology growth per year from 2010 to 2022Total medtech growth per year worldwide 2010-2022

Note: Worldwide; 2010 to 2017

Source: Evaluate ID 329048

Ann

ual g

row

th

2010 2011 2012 2013 2014 2015 2016 2017* 2018* 2019* 2020* 2021* 2022*

0.0%

2.0%

4.0%

6.0%

8.0%

10.0%

-2.0%

-4.0%

5.8%

8%

2.6%

2%

2.7%

-2%

4.2% 4.1%

5.5% 5.5% 5.4% 5.2% 5%

data

Overview

Further information regarding this statistic can be found on page 50.

9

Worldwide research and development spending in medical technology from 2009 to 2022 (in billion U.S. dollars)

Expenditure on research and development in global medtech 2009-2022

Note: Worldwide; 2009 to 2017

Source: Evaluate ID 309297

R&

D s

pend

ing

in b

illio

n U

.S. d

olla

rs

2009 2010 2011 2012 2013 2014 2015 2016 2017* 2018* 2019* 2020* 2021* 2022*0

5

10

15

20

25

30

35

40

2021.2

23.324 24.6 25.2 25.5

26.9 27.128.2

29.530.8

32.133.5

data

Overview

Further information regarding this statistic can be found on page 51.

10

Worldwide medtech research and development spending as percent of medtech revenue from 2009 to 2022

R&D spending as percent of medtech revenue worldwide 2009-2022

Note: Worldwide; 2009 to 2017

Source: Evaluate ID 309305

R&

D s

pend

ing

as p

erce

ntag

e of

reve

nue

2009 2010 2011 2012 2013 2014 2015 2016 2017* 2018* 2019* 2020* 2021* 2022*0.0%

1.0%

2.0%

3.0%

4.0%

5.0%

6.0%

7.0%

8.0%

6.5% 6.5% 6.6% 6.6% 6.7% 6.7%6.9% 6.9%

6.7% 6.6% 6.6% 6.5% 6.5% 6.4%

data

Overview

Further information regarding this statistic can be found on page 52.

11

Worldwide research and development spending growth rate in medical technology from 2010 to 2022

Growth rate in research and development spending in global medtech 2010-2022

Note: Worldwide; 2010 to 2017

Source: Evaluate ID 329054

Gro

wth

rate

2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 20220.0%

2.0%

4.0%

6.0%

8.0%

10.0%

12.0%

5.6%

10.2%

2.7% 2.8%2.4%

0.9%

5.5%

0.9%

4.3% 4.4% 4.4% 4.3% 4.2%

data

Overview

Further information regarding this statistic can be found on page 53.

12

Total revenues of U.S. and European medical technology companies from 2009 to 2016 (in billion U.S. dollars)

U.S. and European medical technology companies - total revenues 2009-2016

Note: Europe; United States

Source: EY; Various sources (Company data); Capital IQ ID 276293

Tota

l rev

enue

in b

illio

n U

.S. d

olla

rs

2009* 2010* 2011* 2012* 2013* 2014* 2015 2016

196.7 196.4206.6 210.5

216.2

234.9

211.3

225.1

106.9117.4

127.3

113.1117.6

106.4

135.9 139.4

Chart Title

U.S. companies European companies

Overview

Further information regarding this statistic can be found on page 54.

13

Number of top medtech companies worldwide from 2013 to 2015, by revenue size*

Number of medtech companies worldwide 2013-2015, by revenue range

Note: Worldwide

Source: EY; Various sources (Company data); Capital IQ ID 277618

Num

ber o

f com

pani

es

0.5-1 billion US$ 1-2.5 billion US$ 2.5-5 billion US$ 5-10 billion US$ More than 10 billion US$0

5

10

15

20

25

30

14

27

9

5

3

15

26

9

5

3

17

27

65

3

Chart Title

2013 2014 2015

CompaniesMedical technology industry

Companies

Further information regarding this statistic can be found on page 55.

15

Top 10 medical technology companies worldwide based on revenue in 2016 (in billion U.S. dollars)

Medical technology - top 10 companies based on revenue 2016

Note: Worldwide

Source: ProClinical ID 281544

Revenue in billion U.S. dollars

0 5 10 15 20 25 30 35

Medtronic Inc., U.S.

Johnson & Johnson Medical Devices & Diagnostics, U.S.

General Electric Healthcare, U.S.

Fresenius Medical Care, Germany

Philips Healthcare, Netherlands

Siemens Sector Healthcare, Germany

Becton Dickinson, U.S.

Cardinal Health Inc., U.S.

Stryker Corp., U.S.

Baxter International Inc., U.S.

29

25.1

18.2

18

16

14.1

12.5

12.4

10.9

10.2

data

Companies

Further information regarding this statistic can be found on page 56.

16

Revenue of Johnson & Johnson's medical devices and diagnostics segment from 2011 to 2016, by franchise (in million U.S. dollars)

Revenue of Johnson & Johnson's medical devices and diagnostics by franchise 2011-2016

Note: Worldwide; 2011 to 2016

Source: Johnson & Johnson ID 266406

Rev

enue

in m

illio

n U

.S. d

olla

rs

2011 2012 2013 2014 2015 20160

5000

10000

15000

20000

25000

30000

Chart Title

Orthopaedics Surgery Vision care Diabetes care Cardiovascular Diagnostics

Companies

Further information regarding this statistic can be found on page 57.

17

Medtronic's total revenue from 2006 to 2017 (in million U.S. dollars)Medtronic's total revenue 2006-2017

Note: Worldwide

Source: Medtronic ID 241515

Rev

enue

in m

illio

n U

.S. d

olla

rs

2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 20170

5000

10000

15000

20000

25000

30000

35000

11,29212,299

13,18614,256

15,392 15,50816,184 16,590 17,005

20,261

28,83329,710

data

Companies

Further information regarding this statistic can be found on page 58.

18

Revenue of General Electric Healthcare from 2008 to 2016 (in billion U.S. dollars)

General Electric revenue in the Healthcare segment 2008-2016

Note: Worldwide

Source: General Electric ID 277734

Rev

enue

in b

illio

n U

.S. d

olla

rs

2008 2009 2010 2011 2012 2013 2014 2015 20160

2

4

6

8

10

12

14

16

18

20

17.4

16

16.9

18.08 18.29 18.2 18.317.64

18.29

data

Companies

Further information regarding this statistic can be found on page 59.

19

Revenue of the Fresenius Group from 2008 to 2016 (in billion euros)Revenue of Fresenius 2008-2016

Note: Worldwide

Source: Fresenius ID 280205

Rev

enue

in b

illio

n eu

ros

2008 2009 2010 2011 2012 2013 2014 2015 20160

5

10

15

20

25

30

35

12.3

14.2

16 16.4

19.320.3

23.2

27.6

29.1

data

Companies

Further information regarding this statistic can be found on page 60.

20

Medical technology revenue of Siemens AG from 2004 to 2017 (in billion euros)*

Medical technology revenue of Siemens 2004-2017

Note: Worldwide

Source: Siemens ID 267010

Rev

enue

in b

illio

n eu

ros

2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 20170

2

4

6

8

10

12

14

16

77.6

8.2

9.8

11.1

11.912.36 12.52

13.64

12.65

11.74

12.9313.54 13.79

data

Companies

Further information regarding this statistic can be found on page 61.

21

Top large medical technology companies based on market capitalization growth in 2016 (in billion U.S. dollars)*

Market capitalization growth of top large medtech companies worldwide 2016

Note: Worldwide

Source: Evaluate ID 440554

Market capitalization growth

0.0% 5.0% 10.0% 15.0% 20.0% 25.0% 30.0% 35.0%

St. Jude Medical

Stryker

Philips

Edwards Lifesciences

C. R. Bard

30%

29%

23%

19%

19%

data

Companies

Further information regarding this statistic can be found on page 62.

22

Top smaller medical technology companies worldwide based on market capitalization growth in 2016*

Market capitalization growth of small medtech companies worldwide 2016

Note: Worldwide

Source: Evaluate ID 440567

Market capitalization growth

0.0% 20.0% 40.0% 60.0% 80.0% 100.0% 120.0% 140.0%

Mazor Robotics

Axogen

Masimo

Align Technology

Cantel Medical

116%

80%

62%

46%

38%

data

Companies

Further information regarding this statistic can be found on page 63.

23

Projected top 10 companies by medical technology revenue in 2022 (in billion U.S. dollars)

Predicted top medical technology companies by revenue 2022

Note: Worldwide; as of September 2017

Source: Evaluate ID 309291

Projected revenue in billion U.S. dollars

0 5 10 15 20 25 30 35 40

Medtronic (U.S.)

Johnson & Johnson (U.S.)

Abbott Laboratories (U.S.)

Siemens (Germany)

Stryker (U.S.)

Philips (Netherlands)

Roche (Switzerland)

Becton Dickinson (U.S.)

Boston Scientific (U.S.)

General Electric (U.S.)

37.7

31

19.5

17

16.5

16.3

14.9

13.7

12.4

12

data

Companies

Further information regarding this statistic can be found on page 64.

24

Leading global medtech companies by R&D spending as a percentage of revenue in 2016 and 2022

Global medical technology R&D spending share in top companies 2016 and 2022

Note: Worldwide; as of September 2017

Source: Evaluate ID 329075

R&D spending as percentage of revenue

0.0% 2.0% 4.0% 6.0% 8.0% 10.0% 12.0% 14.0% 16.0% 18.0%

Edwards Lifesciences

bioMérieux

Abbott Laboratories

Boston Scientific

Danaher

Roche

Siemens

General Electric

3M

Philips

Novartis

Intuitive Surgical

Baxter International

Medtronic

15.2%

15.2%

10.8%

10.1%

9.4%

9.2%

9.1%

9.1%

8.5%

8.4%

7.7%

7.5%

7.4%

7.1%

15%

16.1%

10%

10.9%

10.1%

11.6%

8.8%

9.8%

8.5%

10.5%

8.4%

8.9%

8.2%

7.4%

Chart Title

2022* 2015

SegmentsMedical technology industry

Segments

Further information regarding this statistic can be found on page 65.

26

Top global medical technology segments by market share in 2016 and 2022

Global medtech market share by segment 2016 and 2022

Note: Worldwide; as of September 2017

Source: Evaluate ID 309273

Market share

0.0% 2.0% 4.0% 6.0% 8.0% 10.0% 12.0% 14.0%

In vitro diagnostics (IVD)

Cardiology

Diagnostic imaging

Orthopedics

Ophthalmics

General & plastic surgery

Endoscopy

Drug delivery

Dental

Wound management

Diabetic care

Nephrology

General hospital & healthcare

Neurology

13.3%

11.9%

9.2%

8.5%

6.8%

5.3%

4.9%

4.7%

3.4%

3.2%

3.1%

2.8%

2.4%

2.2%

12.8%

11.5%

10.1%

9%

6.7%

5.3%

4.6%

4.8%

3.3%

3.4%

2.9%

2.9%

2.8%

1.9%

Chart Title

2022* 2016

Segments

Further information regarding this statistic can be found on page 66.

27

Global top 10 companies based on in vitro diagnostics market share in 2016 and 2022

Global in vitro diagnostics market share by top medtech companies 2016 and 2022

Note: Worldwide; as of September 2017

Source: Evaluate ID 331722

Market share

0.0% 2.0% 4.0% 6.0% 8.0% 10.0% 12.0% 14.0% 16.0% 18.0% 20.0% 22.0%

Roche

Danaher

Abbott Laboratoories

Siemens

Thermo Fisher Scientific

Sysmex

Becton Dickinson

bioMérieux

Alere

Ortho Clinical Diagnostics

18.4%

10.4%

9.8%

8%

5.6%

5.1%

5.1%

4.3%

3.8%

2.8%

19.4%

10.2%

9.7%

9.9%

6.3%

4.3%

5.5%

3.8%

4.4%

3.4%

Chart Title

2022* 2016

Segments

Further information regarding this statistic can be found on page 67.

28

Global top 10 companies based on cardiologic medical technology market share in 2016 and 2022

Global cardiology market share by top 10 medtech companies 2016 and 2022

Note: Worldwide; as of September 2017

Source: Evaluate ID 331725

Market share

0.0% 5.0% 10.0% 15.0% 20.0% 25.0%

Medtronic

Abbott Laboratories

Boston Scientific

Edwards Lifesciences

Terumo

Johnson & Johnson

W. L. Gore & Associates

Lepu Medical Technology

Asahi Kasei

Getinge

20.8%

15.6%

12.4%

7.8%

5.8%

4.4%

3.4%

2.9%

2.8%

2.6%

23.5%

6.3%

12.1%

6.6%

4.9%

4.1%

3.6%

1.2%

2.8%

3.1%

Chart Title

2022* 2016

Segments

Further information regarding this statistic can be found on page 68.

29

Global top 10 companies based on diagnostic imaging market share in 2016 and 2022

Global diagnostic imaging market shares of top medtech companies 2016 and 2022

Note: Worldwide; as of September 2017

Source: Evaluate ID 331739

Market share

0.0% 5.0% 10.0% 15.0% 20.0% 25.0% 30.0%

Siemens

General Electric

Philips

Canon

Fujifilm Holdings

Carestream Health

Varex Imaging

Hitachi

Konica Minolta

Shimadzu

23.8%

21.4%

18.9%

8.6%

5.6%

3.3%

3.2%

2.7%

2.1%

1.4%

25.8%

21.4%

18.8%

5.8%

3.2%

3%

2.1%

1.5%

Chart Title

2022* 2016

Segments

Further information regarding this statistic can be found on page 69.

30

Global top 10 companies based on orthopedic medical technology market share in 2016 and 2022

Global orthopedics market share - top medtech companies 2016 and 2022

Note: Worldwide; as of September 2017

Source: Evaluate ID 331747

Market share

0.0% 5.0% 10.0% 15.0% 20.0% 25.0% 30.0%

Johnson & Johnson

Zimmer Biomet

Stryker

Medtronic

Smith & Nephew

Arthrex

NuVasive

Wright Medical Group

Globus Medical

Orthofix International

22.8%

19.8%

17.1%

7.9%

5.5%

4.9%

2.9%

2.9%

2%

1.1%

25.1%

20.7%

16.1%

8.4%

5.7%

4.9%

2.5%

2%

1.6%

1.2%

Chart Title

2022* 2016

Segments

Further information regarding this statistic can be found on page 70.

31

Global top 10 companies based on ophthalmic medtech market share in 2016 and 2022

Global ophthalmics market share of top medtech companies 2016-2022

Note: Worldwide; as of September 2017

Source: Evaluate ID 331762

Market share

0.0% 5.0% 10.0% 15.0% 20.0% 25.0% 30.0% 35.0%

Essilor International

Novartis

Johnson & Johnson

HOYA

Valeant Pharmaceuticals

Carl Zeiss

The Cooper Companies

TOPCON

NIDEK

Nikon

28.6%

19.7%

13.6%

9.3%

9.2%

7.4%

6.4%

1.8%

1.4%

0.8%

26.5%

22.4%

10.7%

8.9%

8.3%

8%

6.1%

1.5%

1.3%

0.7%

Chart Title

2022* 2016

IPOs, M&As, fundingMedical technology industry

IPOs, M&As, funding

Further information regarding this statistic can be found on page 71.

33

Number of medtech IPOs before and after the financial crisis as of 2017Medtech IPOs before and after the financial crisis as of 2017

Note: United States

Source: EY; Dow Jones; Capital IQ; BioCentury ID 277598

Num

ber o

f med

tech

IPO

s

July 2005 to June 2008 average

July 2008 to June 2013 average

July 2013 to June 2014 July 2014 to June 2015 July 2015 to June 2016 July 2016 to June 20170

5

10

15

20

25

30

35

40

45

50

16.3

8.4

34

43

15

21

data

IPOs, M&As, funding

Further information regarding this statistic can be found on page 72.

34

Selected major medtech IPOs in the United States and Europe in 2016-2017, by proceeds (in million U.S. dollars)

Selected major medtech IPOs in the U.S. and Europe by proceeds 2016-2017

Note: Europe; United States; July 2016 to June 2017

Source: EY; Dow Jones; Capital IQ; BioCentury ID 277635

Gross raised in million U.S. dollars

Company name (Location)

0 500 1000 1500 2000 2500

ConvaTec Group (UK)

iRhythm Technologies (France)

Obalon Therapeutics (U.S.)

Bonesupport (Sweden)

Valeritas (U.S.)

Fulgent Genetics (U.S.)

Tactile Systems Technology (U.S.)

InDex Pharmaceuticals Holdings (Sweden)

Creo Medical Group (UK)

Visioneering Technologies (U.S.)

2,010

123

75

58

53

43

41

29

27

25

data

IPOs, M&As, funding

Further information regarding this statistic can be found on page 73.

35

Number of merger and acquisition deals in the medical technology industry worldwide from 2007 to 2016

Number of M&A deals in medical technology worldwide 2007-2016

Note: Worldwide

Source: Evaluate ID 331764

Num

ber o

f mer

ger a

nd a

cqui

sitio

n de

als

2007 2008 2009 2010 2011 2012 2013 2014 2015 20160

50

100

150

200

250

300

267

226

176

267 263

245

230

217227

217

data

IPOs, M&As, funding

Further information regarding this statistic can be found on page 74.

36

Value of merger and acquisition deals in the medical technology industry worldwide from 2007 to 2016 (in billion U.S. dollars)

Value of M&A medical technology company deals worldwide 2007-2016

Note: Worldwide

Source: Evaluate ID 331774

Val

ue in

bill

ion

U.S

. dol

lars

2007 2008 2009 2010 2011 2012 2013 2014 2015 20160

20

40

60

80

100

120

140

52

28

13

21

5045

20

41

128

42

data

IPOs, M&As, funding

Further information regarding this statistic can be found on page 75.

37

Selected top medtech mergers and acquisitions worldwide in 2016-2017, by value (in billion U.S. dollars)

Top medtech mergers and acquisitions by value 2016-2017

Note: Worldwide; July 2016 to June 2017

Source: EY; Thomson Reuters (Thomson One); Capital IQ ID 277638

Value in billion U.S. dollars

Acquiring company/Target company

0 5 10 15 20 25 30

Essilor International (France)/ Luxottica (Italy)

Becton Dickinson (U.S.)/ C.R. Bard (U.S.)

Thermo Fisher Scientific (U.S.)/ Patheon (U.S.)

Cardinal Health (U.S.)/ Medtronic - medical supplies (Ireland)

Johnson & Johnson (U.S.)/ Abbott - medical optics (U.S.)

Danaher (U.S.)/ Cepheid (U.S.)

Svenska Cellulosa Aktiebolaget (Sweden)/ BSN medical (Germany)

Allergan (Ireland)/ Acelity/LifeCell (U.S.)

Allergan (Ireland)/ ZELTIQ Aesthetics (U.S.)

Philips (Netherlands)/ Spectranetics (U.S.)

25.2

24

7.2

6.1

4.3

4

3

2.9

2.5

2.1

data

IPOs, M&As, funding

Further information regarding this statistic can be found on page 76.

38

Medtech venture capital investment in the U.S. and Europe from 2006/2007 to 2016/2017 (in billion U.S. dollars)*

Medtech venture capital investment - U.S. and Europe 2006-2017

Note: Europe; United States

Source: EY; Dow Jones; Capital IQ; BMO Capital Markets ID 279152

VC

inve

stm

ent i

n bi

llion

U.S

. dol

lars

2006/2007 2007/2008 2008/2009 2009/2010 2010/2011 2011/2012 2012/2013 2013/2014 2014/2015 2015/2016 2016/20170

1

2

3

4

5

6

7

8

9

5.4 5.3

4.75

4.2

4.74.4

4.95.2

6.3

7.7

data

Costs and utilizationMedical technology industry

Costs and utilization

Further information regarding this statistic can be found on page 77.

40

Average prices of a magnetic resonance imaging (MRI) in selected countries in 2014 (in U.S. dollars)

Average price of a MRI by country 2014

Note: Worldwide

Source: IFHP; HCCI ID 312020

Price in U.S. dollars

0 200 400 600 800 1000 1200

United States*

New Zealand

United Kingdom

Switzerland

South Africa

Australia

Spain

1,119

811

788

503

455

215

130

data

Costs and utilization

Further information regarding this statistic can be found on page 78.

41

Average hospital and physician costs for hip replacements in selected countries in 2014 (in U.S. dollars)

Average cost of hospital and physicians for hip replacements by country 2014

Note: Worldwide

Source: IFHP; HCCI ID 312247

Average cost in U.S. dollars

0 5000 10000 15000 20000 25000 30000 35000

United States*

Australia

Switzerland

New Zealand

South Africa

Spain

29,067

19,484

17,112

15,465

7,685

6,757

data

Costs and utilization

Further information regarding this statistic can be found on page 79.

42

Average hospital and physician costs for a bypass surgery in selected countries in 2014 (in U.S. dollars)

Average cost of hospital and physicians for bypass surgery by country 2014

Note: Worldwide

Source: IFHP ID 312250

Average cost in U.S. dollars

0 10000 20000 30000 40000 50000 60000 70000 80000 90000

United States*

Switzerland

New Zealand

Australia

United Kingdom

South Africa

Spain

78,318

34,224

32,480

28,888

24,059

18,501

14,579

data

Costs and utilization

Further information regarding this statistic can be found on page 80.

43

Number of magnetic resonance imaging (MRI) units in selected countries as of 2016 (per million population)

MRI units per million: by country 2016

Note: OECD; 2013 to 2016

Source: OECD ID 282401

MRI units per million population

0 10 20 30 40 50 60

Japan (2014)

United States

Germany (2015)

Italy (2015)

South Korea

Finland

Greece (2013)

Iceland

Austria (2015)

Spain (2015)

Ireland

Australia

New Zealand

France

Latvia (2015)

51.67

36.72

33.63

28.24

27.81

25.51

24.26

21.05

20.73

15.87

14.82

14.34

13.85

13.54

12.64

data

Costs and utilization

Further information regarding this statistic can be found on page 81.

44

Number of examinations with magnetic resonance imaging (MRI) in selected countries as of 2015 (per 1,000 population)*

MRI scanner - number of examinations in selected countries 2015

Note: Worldwide

Source: OECD ID 271470

Examinations per thousand population

0 20 40 60 80 100 120 140 160

Turkey

Germany

United States

Japan

France

Belgium

Luxembourg

Denmark

Iceland

Spain

Switzerland*

Greece

OECD-29

Slovak Republic

Canada

144.3

131.3

117.8

112.3

104.8

85.6

82.5

82.1

81.9

78.3

69.9

67.9

64.8

56.8

55.5

data

Costs and utilization

Further information regarding this statistic can be found on page 82.

45

Number of examinations with computer tomography (CT) in selected countries as of 2015 (per 1,000 inhabitants)*

Computer tomography (CT) - number of examinations in selected countries 2015

Note: OECD

Source: OECD ID 283085

Examinations per thousand inhabitants

0 50 100 150 200 250 300

United States

Japan

Luxembourg

Belgium

France

Iceland

Greece

South Korea***

Turkey

Latvia

Portugal*

Denmark

Slovak Republic

Canada

Estonia

245.3

230.8

207.7

198.8

197.4

190.9

181.1

174.9

174.8

168.5

165.3

161.8

156.2

152.8

151.9

data

Costs and utilization

Further information regarding this statistic can be found on page 83.

46

Number of knee replacement surgeries in OECD-countries as of 2015 (per 100,000 inhabitants)*

Number of knee replacements in OECD-countries 2015

Note: Worldwide

Source: OECD ID 236586

Surgeries per 100,000 inhabitants

0 50 100 150 200 250 300

Switzerland

United States

Austria

Germany

Belgium

Australia

Luxembourg

Finland

Canada

Denmark

France

United Kingdom

Netherlands

Iceland

Czech Republic

239.5

225.8

215

205.8

202.3

197.2

189.2

187

177.8

167.7

159.9

148.8

138.3

131.9

126.3

data

ReferencesMedical technology industry

References 48

Total global medical technology revenue from 2009 to 2022 (in billion U.S. dollars)

Source and methodology information

Source Evaluate

Conducted by Evaluate (EvaluateMedTech)

Survey period 2009 to 2017

Region Worldwide

Number of respondents n.a.

Age group n.a.

Special characteristics n.a.

Published by Evaluate

Publication date September 2017

Original source EvaluateMedTech - World Preview 2017, Outlook to 2022, page 14

Website URL visit the website

Total medtech revenue worldwide 2009-2022

Notes:Statistic is based on the top 300 medtech companies. Sales to 2016 based on company reported sales data. Sales forecasts to 2022 based on a consensus of leading equity analysts` estimates for segmental sales. * Forecast.

References 49

Total global medical technology growth per year from 2010 to 2022

Source and methodology information

Source Evaluate

Conducted by Evaluate (EvaluateMedTech)

Survey period 2010 to 2017

Region Worldwide

Number of respondents n.a.

Age group n.a.

Special characteristics n.a.

Published by Evaluate

Publication date September 2017

Original source EvaluateMedTech - World Preview 2017, Outlook to 2022, page 15

Website URL visit the website

Total medtech growth per year worldwide 2010-2022

Notes:Sales to 2016 based on company reported sales data. Sales forecasts to 2022 based on a consensus of leading equity analysts` estimates for segmental sales. * Forecast.

References 50

Worldwide research and development spending in medical technology from 2009 to 2022 (in billion U.S. dollars)

Source and methodology information

Source Evaluate

Conducted by Evaluate (EvaluateMedTech)

Survey period 2009 to 2017

Region Worldwide

Number of respondents n.a.

Age group n.a.

Special characteristics n.a.

Published by Evaluate

Publication date September 2017

Original source EvaluateMedTech - World Preview 2017, Outlook to 2022, page 16

Website URL visit the website

Expenditure on research and development in global medtech 2009-2022

Notes:Statistic is based on the top 300 medtech companies. R&D spend in 2016 based on company reported data. Forecast medtech R&D spend based on a consensus of leading equity analysts` estimates for company level R&D spend, extrapolated to medtech R&D when a company has non-medtech R&D activity.Medtech R&D is not disclosed by a number of companies and this analysis is limited to those companies with sufficient disclosure. * Forecast.

References 51

Worldwide medtech research and development spending as percent of medtech revenue from 2009 to 2022

Source and methodology information

Source Evaluate

Conducted by Evaluate (EvaluateMedTech)

Survey period 2009 to 2017

Region Worldwide

Number of respondents n.a.

Age group n.a.

Special characteristics n.a.

Published by Evaluate

Publication date September 2017

Original source EvaluateMedTech - World Preview 2017, Outlook to 2022, page 16

Website URL visit the website

R&D spending as percent of medtech revenue worldwide 2009-2022

Notes:Statistic is based on the top 300 medtech companies. R&D spend in 2016 based on company reported data. Forecast medtech R&D spend based on a consensus of leading equity analysts` estimates for company level R&D spend, extrapolated to medtech R&D when a company has non-medtech R&D activity.Medtech R&D is not disclosed by a number of companies and this analysis is limited to those companies with sufficient disclosure. * Forecast.

References 52

Worldwide research and development spending growth rate in medical technology from 2010 to 2022

Source and methodology information

Source Evaluate

Conducted by Evaluate (EvaluateMedTech)

Survey period 2010 to 2017

Region Worldwide

Number of respondents n.a.

Age group n.a.

Special characteristics n.a.

Published by Evaluate

Publication date September 2017

Original source EvaluateMedTech - World Preview 2017, Outlook to 2022, page 16

Website URL visit the website

Growth rate in research and development spending in global medtech 2010-2022

Notes:Statistic is based on the top 300 medtech companies. R&D spend in 2016 based on company reported data. Forecast medtech R&D spend based on a consensus of leading equity analysts` estimates for company level R&D spend, extrapolated to medtech R&D when a company has non-medtech R&D activity.Medtech R&D is not disclosed by a number of companies and this analysis is limited to those companies with sufficient disclosure. * From 2017 on projected.

References 53

Total revenues of U.S. and European medical technology companies from 2009 to 2016 (in billion U.S. dollars)

Source and methodology information

Source EY; Various sources (Company data); Capital IQ

Conducted by EY; Capital IQ; Various sources (Company data)

Survey period 2009 to 2016

Region Europe; United States

Number of respondents n.a.

Age group n.a.

Special characteristics n.a.

Published by EY

Publication date September 2017

Original source EY - Medical technology report 2017, page 42 and 46

Website URL visit the website

U.S. and European medical technology companies - total revenues 2009-2016

Notes:Including data for public conglomerates and pure-play companies. * Figures were taken from previous reports.

References 54

Number of top medtech companies worldwide from 2013 to 2015, by revenue size*

Source and methodology information

Source EY; Various sources (Company data); Capital IQ

Conducted by EY; Capital IQ; Various sources (Company data)

Survey period 2013 to 2015

Region Worldwide

Number of respondents n.a.

Age group n.a.

Special characteristics n.a.

Published by EY

Publication date October 2016

Original source EY - Medical technology report 2016, page 22

Website URL visit the website

Number of medtech companies worldwide 2013-2015, by revenue range

Notes:* This statistic includes only European and U.S. companies, which represent the vast majority of global top medtech companies (commercial leaders). Commercial leaders are pure-play companies with revenues in excess of US$1 billion.

References 55

Top 10 medical technology companies worldwide based on revenue in 2016 (in billion U.S. dollars)

Source and methodology information

Source ProClinical

Conducted by Various sources (company data); ProClinical

Survey period 2016

Region Worldwide

Number of respondents n.a.

Age group n.a.

Special characteristics n.a.

Published by ProClinical

Publication date July 2017

Original source proclinical.com

Website URL visit the website

Medical technology - top 10 companies based on revenue 2016

Notes:n.a.

References 56

Revenue of Johnson & Johnson's medical devices and diagnostics segment from 2011 to 2016, by franchise (in million U.S. dollars)

Source and methodology information

Source Johnson & Johnson

Conducted by Johnson & Johnson

Survey period 2011 to 2016

Region Worldwide

Number of respondents n.a.

Age group n.a.

Special characteristics n.a.

Published by Johnson & Johnson

Publication date February 2017

Original source Johnson & Johnson - Form 10-K 2016, page 20

Website URL visit the website

Revenue of Johnson & Johnson's medical devices and diagnostics by franchise 2011-2016

Notes:n.a.

References 57

Medtronic's total revenue from 2006 to 2017 (in million U.S. dollars)

Source and methodology information

Source Medtronic

Conducted by Medtronic

Survey period fiscal years 2006 to 2017

Region Worldwide

Number of respondents n.a.

Age group n.a.

Special characteristics n.a.

Published by Medtronic

Publication date June 2017

Original source Medtronic - 2017 Form 10-K, page 38

Website URL visit the website

Medtronic's total revenue 2006-2017

Notes:All figures are for the fiscal year ending on the last Friday in April. This statistic was assembled from several Medtronic annual reports.

References 58

Revenue of General Electric Healthcare from 2008 to 2016 (in billion U.S. dollars)

Source and methodology information

Source General Electric

Conducted by General Electric

Survey period 2008 to 2016

Region Worldwide

Number of respondents n.a.

Age group n.a.

Special characteristics n.a.

Published by General Electric

Publication date February 2017

Original source General Electric 2016 Annual Report on Form 10-K, page 35

Website URL visit the website

General Electric revenue in the Healthcare segment 2008-2016

Notes:Figures prior to 2012 were added from older annual reports.

References 59

Revenue of the Fresenius Group from 2008 to 2016 (in billion euros)

Source and methodology information

Source Fresenius

Conducted by Fresenius

Survey period 2008 to 2016

Region Worldwide

Number of respondents n.a.

Age group n.a.

Special characteristics n.a.

Published by Fresenius

Publication date March 2017

Original source Fresenius - 2016 Annual Report, page 101

Website URL visit the website

Revenue of Fresenius 2008-2016

Notes:All figures are rounded. Figures prior to 2015 are taken from previous editions.

References 60

Medical technology revenue of Siemens AG from 2004 to 2017 (in billion euros)*

Source and methodology information

Source Siemens

Conducted by Siemens

Survey period 2004 to 2017

Region Worldwide

Number of respondents n.a.

Age group n.a.

Special characteristics n.a.

Published by Siemens

Publication date November 2017

Original source Siemens - Earnings Release Q4 FY 2017, page xv

Website URL visit the website

Medical technology revenue of Siemens 2004-2017

Notes:* Revenue of Siemens Healthcare for years ended on September 30. This statistic was assembled from several annual reports.

References 61

Top large medical technology companies based on market capitalization growth in 2016 (in billion U.S. dollars)*

Source and methodology information

Source Evaluate

Conducted by Evaluate (EvaluateMedTech)

Survey period 2016

Region Worldwide

Number of respondents n.a.

Age group n.a.

Special characteristics n.a.

Published by Evaluate; EP Vantage

Publication date February 2017

Original source EP Vantage - Medtech 2016 in Review, page 6

Website URL visit the website

Market capitalization growth of top large medtech companies worldwide 2016

Notes:* Companies with market cap larger than 10 billion U.S. dollars. Growth based on share price change.

References 62

Top smaller medical technology companies worldwide based on market capitalization growth in 2016*

Source and methodology information

Source Evaluate

Conducted by Evaluate (EvaluateMedTech)

Survey period 2016

Region Worldwide

Number of respondents n.a.

Age group n.a.

Special characteristics n.a.

Published by Evaluate; EP Vantage

Publication date February 2017

Original source EP Vantage - Medtech 2016 in Review, page 7

Website URL visit the website

Market capitalization growth of small medtech companies worldwide 2016

Notes:* Companies with market cap smaller than 10 billion U.S. dollars. Growth based on share price change.

References 63

Projected top 10 companies by medical technology revenue in 2022 (in billion U.S. dollars)

Source and methodology information

Source Evaluate

Conducted by Evaluate (EvaluateMedTech)

Survey period as of September 2017

Region Worldwide

Number of respondents n.a.

Age group n.a.

Special characteristics n.a.

Published by Evaluate

Publication date September 2017

Original source EvaluateMedTech - World Preview 2017, Outlook to 2022, page 12

Website URL visit the website

Predicted top medical technology companies by revenue 2022

Notes:All figures are forecasts. Statistic is based on the top 300 medtech companies. Sales in 2016 based on company reported data. Sales forecasts to 2022 based on a consensus of leading equity analysts` estimates forsegmental sales.

References 64

Leading global medtech companies by R&D spending as a percentage of revenue in 2016 and 2022

Source and methodology information

Source Evaluate

Conducted by Evaluate (EvaluateMedTech)

Survey period as of September 2017

Region Worldwide

Number of respondents n.a.

Age group n.a.

Special characteristics n.a.

Published by Evaluate

Publication date September 2017

Original source EvaluateMedTech - World Preview 2017, Outlook to 2022, page 17-18

Website URL visit the website

Global medical technology R&D spending share in top companies 2016 and 2022

Notes:Analysis is based on the top 300 medtech companies. R&D spend in 2016 based on company reported data.Forecast medtech R&D spend based on a consensus of leading equity analysts` estimates for company level R&D spend, extrapolated to medtech R&D when a company has non-medtech R&D activity.Medtech R&D is not disclosed by a number of companies and this analysis is limited to those companies with sufficient disclosure. * Forecast.

References 65

Top global medical technology segments by market share in 2016 and 2022

Source and methodology information

Source Evaluate

Conducted by Evaluate (EvaluateMedTech)

Survey period as of September 2017

Region Worldwide

Number of respondents n.a.

Age group n.a.

Special characteristics n.a.

Published by Evaluate

Publication date September 2017

Original source EvaluateMedTech - World Preview 2017, Outlook to 2022, page 9

Website URL visit the website

Global medtech market share by segment 2016 and 2022

Notes:Figures are based on the top 300 medtech companies. Sales forecasts to 2022 based on a consensus of leading equity analysts` estimates for segmental sales. * Forecast.

References 66

Global top 10 companies based on in vitro diagnostics market share in 2016 and 2022

Source and methodology information

Source Evaluate

Conducted by Evaluate (EvaluateMedTech)

Survey period as of September 2017

Region Worldwide

Number of respondents n.a.

Age group n.a.

Special characteristics n.a.

Published by Evaluate

Publication date September 2017

Original source EvaluateMedTech - World Preview 2017, Outlook to 2022, page 25

Website URL visit the website

Global in vitro diagnostics market share by top medtech companies 2016 and 2022

Notes:Market share based on revenues. Excludes glucose test systems which are included in diabetic care classification. * Projected.

References 67

Global top 10 companies based on cardiologic medical technology market share in 2016 and 2022

Source and methodology information

Source Evaluate

Conducted by Evaluate (EvaluateMedTech)

Survey period as of September 2017

Region Worldwide

Number of respondents n.a.

Age group n.a.

Special characteristics n.a.

Published by Evaluate

Publication date September 2017

Original source EvaluateMedTech - World Preview 2017, Outlook to 2022, page 26

Website URL visit the website

Global cardiology market share by top 10 medtech companies 2016 and 2022

Notes:General Electric & Philips do not disclose cardiology sales. Revenues for St. Jude Medical are included in Abbott`s 2022 forecast but not in the 2016 reported sales. Abbott completed the acquisition of St. Jude Medical on 4 January 2017. St. Jude Medical was estimated to have cardiology sales of $5.5bn in 2016. * Projected.

References 68

Global top 10 companies based on diagnostic imaging market share in 2016 and 2022

Source and methodology information

Source Evaluate

Conducted by Evaluate (EvaluateMedTech)

Survey period as of September 2017

Region Worldwide

Number of respondents n.a.

Age group n.a.

Special characteristics n.a.

Published by Evaluate

Publication date September 2017

Original source EvaluateMedTech - World Preview 2017, Outlook to 2022, page 27

Website URL visit the website

Global diagnostic imaging market shares of top medtech companies 2016 and 2022

Notes:Market share based on revenues. Segment sales include servicing of equipment. * Projected.

References 69

Global top 10 companies based on orthopedic medical technology market share in 2016 and 2022

Source and methodology information

Source Evaluate

Conducted by Evaluate (EvaluateMedTech)

Survey period as of September 2017

Region Worldwide

Number of respondents n.a.

Age group n.a.

Special characteristics n.a.

Published by Evaluate

Publication date September 2017

Original source EvaluateMedTech - World Preview 2017, Outlook to 2022, page 28

Website URL visit the website

Global orthopedics market share - top medtech companies 2016 and 2022

Notes:Market share based on revenues. * Projected.

References 70

Global top 10 companies based on ophthalmic medtech market share in 2016 and 2022

Source and methodology information

Source Evaluate

Conducted by Evaluate (EvaluateMedTech)

Survey period as of September 2017

Region Worldwide

Number of respondents n.a.

Age group n.a.

Special characteristics n.a.

Published by Evaluate

Publication date September 2017

Original source EvaluateMedTech - World Preview 2017, Outlook to 2022, page 29

Website URL visit the website

Global ophthalmics market share of top medtech companies 2016-2022

Notes:* Projected.

References 71

Number of medtech IPOs before and after the financial crisis as of 2017

Source and methodology information

Source EY; Dow Jones; Capital IQ; BioCentury

Conducted by EY; Capital IQ; Dow Jones (VentureSource); BioCentury

Survey period 2005 to 2017

Region United States

Number of respondents n.a.

Age group n.a.

Special characteristics n.a.

Published by EY

Publication date September 2017

Original source EY - Medical technology report 2017, page 58

Website URL visit the website

Medtech IPOs before and after the financial crisis as of 2017

Notes:Data are assembled from EY's 2013-2017 medtech reports.

References 72

Selected major medtech IPOs in the United States and Europe in 2016-2017, by proceeds (in million U.S. dollars)

Source and methodology information

Source EY; Dow Jones; Capital IQ; BioCentury

Conducted by EY; Dow Jones (VentureSource); Capital IQ; BioCentury

Survey period July 2016 to June 2017

Region Europe; United States

Number of respondents n.a.

Age group n.a.

Special characteristics n.a.

Published by EY

Publication date September 2017

Original source EY - Medical technology report 2017, page 59

Website URL visit the website

Selected major medtech IPOs in the U.S. and Europe by proceeds 2016-2017

Notes:n.a.

References 73

Number of merger and acquisition deals in the medical technology industry worldwide from 2007 to 2016

Source and methodology information

Source Evaluate

Conducted by Evaluate (EvaluateMedTech)

Survey period 2007 to 2016

Region Worldwide

Number of respondents n.a.

Age group n.a.

Special characteristics n.a.

Published by Evaluate; EP Vantage

Publication date February 2017

Original source EP Vantage - Medtech 2016 in Review, page 3

Website URL visit the website

Number of M&A deals in medical technology worldwide 2007-2016

Notes:Data based on closing date of deal.

References 74

Value of merger and acquisition deals in the medical technology industry worldwide from 2007 to 2016 (in billion U.S. dollars)

Source and methodology information

Source Evaluate

Conducted by Evaluate (EvaluateMedTech)

Survey period 2007 to 2016

Region Worldwide

Number of respondents n.a.

Age group n.a.

Special characteristics n.a.

Published by Evaluate; EP Vantage

Publication date February 2017

Original source EP Vantage - Medtech 2016 in Review, page 3

Website URL visit the website

Value of M&A medical technology company deals worldwide 2007-2016

Notes:Data based on closing date of deal. All values are rounded.

References 75

Selected top medtech mergers and acquisitions worldwide in 2016-2017, by value (in billion U.S. dollars)

Source and methodology information

Source EY; Thomson Reuters (Thomson One); Capital IQ

Conducted by EY; Capital IQ; Thomson Reuters (Thomson One)

Survey period July 2016 to June 2017

Region Worldwide

Number of respondents n.a.

Age group n.a.

Special characteristics n.a.

Published by EY

Publication date September 2017

Original source EY - Medical technology report 2017, page 76

Website URL visit the website

Top medtech mergers and acquisitions by value 2016-2017

Notes:Only selected top M&As are displayed in the graph. * Announced acquisitions that have not closed as of 30 September 2016.

References 76

Medtech venture capital investment in the U.S. and Europe from 2006/2007 to 2016/2017 (in billion U.S. dollars)*

Source and methodology information

Source EY; Dow Jones; Capital IQ; BMO Capital Markets

Conducted by EY; BMO Capital Markets; Dow Jones; Capital IQ

Survey period 2006 to 2017

Region Europe; United States

Number of respondents n.a.

Age group n.a.

Special characteristics n.a.

Published by EY

Publication date September 2017

Original source EY - Medical technology report 2017, page 53

Website URL visit the website

Medtech venture capital investment - U.S. and Europe 2006-2017

Notes:* Financial year July to June. ** Figures taken from previous reports.

References 77

Average prices of a magnetic resonance imaging (MRI) in selected countries in 2014 (in U.S. dollars)

Source and methodology information

Source IFHP; HCCI

Conducted by IFHP; HCCI

Survey period 2014

Region Worldwide

Number of respondents n.a.

Age group n.a.

Special characteristics n.a.

Published by IFHP

Publication date July 2016

Original source IFHP - 2015 Comparative Price Report, page 13

Website URL visit the website

Average price of a MRI by country 2014

Notes:* 25th percentile: 448 U.S. dollars; 95th percentile: 3,031 U.S. dollars.

References 78

Average hospital and physician costs for hip replacements in selected countries in 2014 (in U.S. dollars)

Source and methodology information

Source IFHP; HCCI

Conducted by IFHP; HCCI

Survey period 2014

Region Worldwide

Number of respondents n.a.

Age group n.a.

Special characteristics n.a.

Published by IFHP

Publication date July 2016

Original source IFHP - 2015 Comparative Price Report, page 22

Website URL visit the website

Average cost of hospital and physicians for hip replacements by country 2014

Notes:* 25th percentile: 18,810 U.S. dollars; 95th percentile: 57,225 U.S. dollars.

References 79

Average hospital and physician costs for a bypass surgery in selected countries in 2014 (in U.S. dollars)

Source and methodology information

Source IFHP

Conducted by IFHP

Survey period 2014

Region Worldwide

Number of respondents n.a.

Age group n.a.

Special characteristics n.a.

Published by IFHP

Publication date July 2016

Original source IFHP - 2015 Comparative Price Report, page 23

Website URL visit the website

Average cost of hospital and physicians for bypass surgery by country 2014

Notes:* 25th percentile: 50,859 U.S. dollars; 95th percentile: 161,148 U.S. dollars.

References 80

Number of magnetic resonance imaging (MRI) units in selected countries as of 2016 (per million population)

Source and methodology information

Source OECD

Conducted by OECD

Survey period 2013 to 2016

Region OECD

Number of respondents n.a.

Age group n.a.

Special characteristics n.a.

Published by OECD

Publication date December 2017

Original source oecd.org

Website URL visit the website

MRI units per million: by country 2016

Notes:Data are for 2016 or latest year available (in brackets).

References 81

Number of examinations with magnetic resonance imaging (MRI) in selected countries as of 2015 (per 1,000 population)*

Source and methodology information

Source OECD

Conducted by OECD

Survey period as of 2013

Region Worldwide

Number of respondents n.a.

Age group n.a.

Special characteristics n.a.

Published by OECD

Publication date November 2017

Original source OECD - Health at a Glance 2017, page 171

Website URL visit the website

MRI scanner - number of examinations in selected countries 2015

Notes:All values are for 2015 or latest year available. * Exams outside hospital not included. ** Exams on public patients not included: Australia,. *** Exams privately-funded not included: Netherlands, South Korea.

References 82

Number of examinations with computer tomography (CT) in selected countries as of 2015 (per 1,000 inhabitants)*

Source and methodology information

Source OECD

Conducted by OECD

Survey period 2015

Region OECD

Number of respondents n.a.

Age group n.a.

Special characteristics n.a.

Published by OECD

Publication date November 2017

Original source OECD - Health at a Glance 2017, page 171

Website URL visit the website

Computer tomography (CT) - number of examinations in selected countries 2015

Notes:All data from 2015 or latest year available. * Exams outside hospital not included. ** Exams performed on public patients not included. *** Exams privately-funded not included.

References 83

Number of knee replacement surgeries in OECD-countries as of 2015 (per 100,000 inhabitants)*

Source and methodology information

Source OECD

Conducted by OECD

Survey period 2015

Region Worldwide

Number of respondents n.a.

Age group n.a.

Special characteristics n.a.

Published by OECD

Publication date November 2017

Original source OECD - Health at a Glance 2017, page 179

Website URL visit the website

Number of knee replacements in OECD-countries 2015

Notes:* Data from 2015 or latest year available. All numbers are rounded.