Medical Chemistry

Medical Chemistry

Chemistry in its relation to pharmacy, physiology, or any science connected with medicine.

Introduction

Medical chemistry is based on General chemistry (physical chemistry)Inorganic chemistry, Organic chemistry, Analytical chemistryIt supports several basic medical disciplines, asmedical biochemistry, physiology, pathophysiology, pharmacology, etc.

Organization of the first semester I

Textbooks required

General chemistry

Textbook: Mc Murry Fay : Chemistry, 4th Edition

(Ebbing: General Chemistry, last Edition)

or other kinds of textbooks

Organic chemistry

Textbook: P.Gergely: Organic and bioorganic chemistry for medical students (3rd edition)

Recommended literature:

McMurry, Fay: Chemistry

4th ed.

P. Gergely: Organic and bioorganic chemistry 3rd ed.

Organization of the first semester II

Inorganic chemistry

Textbook: Experiments in medical chemistry (Laboratory manual) edited by V. Nagy

Analytical chemistry

Textbook: Experiments in medical chemistry (Laboratory manual) edited by V. Nagy

Syllabi are avaible at:

www.pote.hu ETR CooSpace Medical Chemistry

or

www.pote.hu Departments Biochem. and Med. Chem. Educational Materials Medical Chemistry

Laboratory experiments in medical chemistry

ed. Veronika Nagy

Available only on internet!

Laboratory experiments in medical chemistry

Written by

Attila Agcs, Zoltn Berente, Gergely Gulys, Pter Jakus, Tams Lrnd, Veronika Nagy, Erika Rad-Turcsi, Anik Taktsy

Edited by

Veronika Nagy

University of Pcs

Department of Biochemistry and Medical Chemistry

Bioorganic chemistry

Textbook see above P. Gergely: Organic and bioorganic chemistry for medical students (3rd edition)

Bioinorganic chemistry

Textbook: P. Gergely: Introduction to bioinorganic chemistry (3rd, revised edition)

Organization of the second semester

Practices I

Form: simple experiments performed by the students themselves

and a few demonstrations (done by the staff)

Topics in the first semester

Basics of inorganic and general and analytical chemistry

Practices II

Topics in the second semesterBasics of complex chemistry, organic chemistry and modern separation methods

Practices III

Laboratory SafetyChemical laboratory is a hazardous place.The students are obliged to wear a lab coat and approved safety glasses or goggles. These are to provided by the students.Packbacks, coats and other belongings should be left in the students locker or the cloakroom before practices.

Practices IV

Other rules will be discussed on the first meeting with your practice leader.

Seminars

Topics in the first semester.They cover the main parts of general and organic chemistryForm: short revision of a chapter of general chemistry + practicing chemical calculations revision of the essentials of organic chemistry(Calculation exercises, educational material on the internet!)

Attendance

Attendance at lecturesAttendance at seminars and practices is obligatory.Criteria of accepted semester

Examination I

First semester

Semester exam: written exam

Topics: cover general and inorganic and organic chemistry

Examination II

Results of the academic year 2009-2010 /first semester

Total number of students:

230 persons (100%)

failed: 90 persons (39%)

passed: 108 persons (47%)

disappeared: 32 persons (14%)

http://aok.pte.hu/index.php?page=egyseg&egy_id=20&nyelv=eng&menu=okt_anyag

Use the material under

Medical Chemistry 2010/2011

Educational materials, as sample tests, lectures, etc. are available here.

Web site of the Biochemistry and Medical Chemistry

Criterion Discipline: General Chemistry I

Time frame: 2 hours / week, 28 hours / semester

Subject of General chemistry: calculation exercises

Requirements: the students are obliged to write two midterm test papers on the 6th and 13th weeks.

Criterion Discipline: General Chemistry II

On these test 2x8, i.e. 16 points can be gathered, which is counted into the final mark of Medical Chemistry.

One should reach at least the 30% (5 points) on the two test altogether and should participate on the 75% of the classes.

To fulfil the requirements of General Chemistry is a prerequisite for the valid semester in Medical Chemistry.

What is the subject of chemistry?

Chemistry is a branch of science discussing the matter, dealing with its composition, structure, behaviour, in addition with its chemical reactions.

Short History of Chemistry I

Practical arts (Egypt and Mesopotamia, to 600 BC)manufacturing of perfumessmelting of metalsmanufacturing of drugsbrewing (preparation of beer)

Short History of Chemistry II

Greek period (600 BC-300 BC)Developing the idea of atomThe concept of the four elements: earth, air, fire, water

Short History of Chemistry III

Alchemy, Alexandrian and the Muslim world (300 BC to 1650 AD )Invention of processes as distillation, sublimation, crystallization, oxidationDiscovery of several elementsConcepts as acid-base and alkali originated from the Arabic word al-kiliIndustrial chemistry: production of paper

Short History of Chemistry IV

Iatrochemistry - chemical discipline connected to medicine. Paracelsus: The true use of chemistry is not to make gold but to prepare medicines.

Mercury unites with sulphur

Short History of Chemistry V

Phlogiston theoryThe chemists tried to explain different phenomena as burning, rusting and metabolism on a common base.Theory: the combustible objects contain a fire-like element, phlogiston, it is liberated during combustion.

Short History of Chemistry VI

Modern chemistry, Antoine Lavoisier, the father of the modern chemistryLaws of chemistryChemical nomenclature and pioneer in stoichiometry, etc.

A. Lavoisier

Importance of chemistry for medical students I

General chemistryBasic principles and facts used by biology, physiology, etcE.g.: term of pH - importance of pH regarding the body fluids, enzymatic performance, etc.

Importance of chemistry for medical students II

E. g. Distribution law of Nernst absorption of lipid soluble drugs, mechanism of action of anaesthetics, etc.E. g. Intermolecular forces - mechanism of action of some medicinesprotein binding of medicines

Organic and bioorganic chemistry I

E. g. Hydroxylation of aromatic compounds- metabolism and changes in renal excretionE. g. Similarity of molecule structure similarity of pharmacological actionE. g. Cis-trans isomerism of substances varying toxicity of cis-trans isomeric compounds

Organic and bioorganic chemistry II

E.g. acetylene groups (triple bond)- role in drugs (in steroid contraceptive agents)E.g. reaction of thiols with heavy metals toxicity of heavy metals (possible targets: thiol enzymes)