M.C. Parolin - Arrow Diagnostics€¦ · Antonella Castagna, Milan Rossana Cavallo, Turin Paola De Benedictis, Legnaro (PD) Antonina Dolei, Sassari Davide Gibellini, Verona Giorgio

3rd

of the ItalianSocietyfor Virology

nationalcongress

One Virology One Health

PaduaSeptember

10-12, 2019Università degli Studi

di Padova

Chairs:G. Palù,

M.C. Parolin

SCIENTIFIC PROGRAMMEwww.congressosiv-isv2019.it

3rd


nationalcongress


PaduaSeptember


di Padova

Chairs:G. Palù,

M.C. Parolin


2

Ministero della Salute

AIFA, Agenzia Italiana del Farmaco

CNR, Consiglio Nazionale delle Ricerche

Regione Veneto

Comune di Padova

Università degli Studi di Padova

Azienda Ospedaliera di Padova

ENDORSEMENTS

national congress3rdof the Italian Society for VirologyOne Virology One Health

PaduaSeptember 10-12, 2019Università degli Studi di Padova

3

RATIONALEThe National Congress of the Italian Society for

Virology represents the annual forum for the Italian scientists

working in the different areas of Virology (medical-clinical Virolo-

gy, molecular Virology, veterinary Virology, environmental and plant

Virology) involving basic, clinical and translational research and taking

advantage of the most advanced technological platforms.

In keeping with the tradition, the scientific structure of Congress features

different thematic sessions: antiviral therapy, emerging viruses and zoonosis,

environmental and plant virology, human viral diseases, infection & immunity and

vaccinology, veterinary virology, viral diagnosis, viral genetics and biotechnology,

viral oncology, virus-host interactions. Every session starts with a Keynote Lecture

followed by oral communications selected from the “Call for Abstracts”.

Poster Exhibition and Discussions complete the scientific structure of the Congress.

The 3rd National Congress of the Italian Society for Virology has been accredited

to the Italian Ministry of Health for CME Credits for the following professionals:

Medical Doctor (all disciplines), Biologist, Biotechnologist, Medical laboratory

technician, Veterinary, Pharmacist, Physicist and Chemist.

4



CHAIRSGiorgio Palù, Padua

Maria Cristina Parolin, Padua

SCIENTIFICSECRETARIATGuido Antonelli, Rome

Maria Serena Beato, Legnaro (PD)

Arianna Calistri, Padua

Arnaldo Caruso, Brescia

Rossana Cavallo, Turin

Massimo Clementi, Milan

Dario Di Luca, Ferrara

Davide Gibellini, Verona

Saverio Parisi, Padua

Maria Carla Re, Bologna

Luisa Rubino, Bari

EXECUTIVE BOARDCanio Buonavoglia, Bari

Massimo Clementi, Milan

Francesco Di Serio, Bari

Giorgio Gribaudo, Turin

Giorgio Palù (President), Padua

ADVISORY COUNCILElisabetta Affabris, Rome

Guido Antonelli, Rome

Fausto Baldanti, Pavia

Roberto Burioni, Milan




Riccardo Dolcetti, Aviano (PN)

Antonina Dolei, Sassari

Alfredo Garzino Demo, Padua

Antonio Mastino, Messina

Mauro Pistello, Pisa

Luisa Rubino, Bari

Enzo Tramontano, Cagliari

Maurizio Zazzi, Siena

5



FACULTYRoberto Accolla, Varese

Elisabetta Affabris, Rome

Antonio Alcamí, Madrid

Andrea Antinori, Rome

Guido Antonelli, Rome

Lawrence Banks, Trieste

Maria Serena Beato, Legnaro (PD)

Alessandra Biffi, Padua

Paolo Bonaldo, Padua

Franco Buonaguro, Naples

Canio Buonavoglia, Bari



Antonella Castagna, Milan


Paola De Benedictis, Legnaro (PD)

Antonina Dolei, Sassari

Davide Gibellini, Verona

Giorgio Gribaudo, Turin

Harald zur Hausen, Heidelberg

Stuart Le Grice, Frederick

Fabrizio Maggi, Pisa

Antonio Mastino, Messina

Edward Mocarski, Atlanta

Beatriz Navarro, Bari

Giorgio Palù, Padua

Saverio Parisi, Padua

Maria Cristina Parolin, Padua

Mauro Pistello, Pisa

Maria Carla Re, Bologna

Rosario Rizzuto, Padua

Luisa Rubino, Bari

Alessandra Scagliarini, Bologna

Troels Scheel, Copenhagen

Guido Silvestri, Atlanta

Enzo Tramontano, Cagliari

Massimo Turina, Turin

Marietjie Venter, Pretoria

Aldo Venuti, Rome

Maurizio Zazzi, Siena

6

TUESDAY, SEPTEMBER 1011.00-11.15 Registration of participants11.15-11.30 Welcome addresses from the SIV-ISV President

11.30-13.00 Session 1 VIRUS-HOST INTERACTIONS Chairs: Giorgio Gribaudo (Turin), Antonio Mastino (Messina)

11.30-11.50 Interplay between RNA viruses and non-coding RNA Troels Scheel, Copenhagen

12.00-13.00 Oral communications

OC 01 B-cell clonogenic activity of HIV-1 p17 variants is driven by EGF transactivation and MMP activity C. Giagulli, F. Caccuri, A. Zani, F. Filippini, A. Bugatti, A. Caruso Section of Microbiology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy

OC 02 TRIM22 binds to CIITA and sequesters it into nuclear bodies containing TRIM19/PML and Cyclin T1 G. Forlani1, F. Turrini2, G. Poli3,4, E. Vicenzi2, R.S. Accolla1

1General Pathology and Immunology Labs “Giovanna Tosi”, Department of Medicine and Surgery, School of Medicine, University of Insubria, Varese, Italy, 2Viral Pathogens and Biosafety Unit, San Raffaele Scientific Institute, Milano, Italy, 3AIDS Immunopathogenesis Unit, San Raffaele Scientific Institute, Milano, Italy, 4Vita-Salute San Raffaele University, School of Medicine, Milano, Italy

OC 03 Structural and dynamic determinants of HCV/E2 sensitivity to neutralization M. Castelli1, E. Augestad2, N. Clementi1, E. Criscuolo1, R. Burioni1, J. Prentoe2, M. Clementi1, N. Mancini1

1Laboratory of Microbiology and Virology, Università “Vita-Salute” San Raffaele, Milan, Italy, 2Copenhagen Hepatitis C Program (CO-HEP), University of Copenhagen, Denmark

OC 04 HHV-6A infection of endometrial epithelial cells affects miRNA expression and trophoblast cell attachment I. Soffritti, M. D’Accolti, D. Bortolotti, V. Gentili, D. Di Luca, R. Rizzo, E. Caselli Section of Microbiology and Medical Genetics, Department of Medical Sciences, University of Ferrara, Ferrara, Italy

OC 05 Towards the production of an infectious viral clone to interfere with phytoplasma transmission by the leafhopper Euscelidius variegatus S. Ottati1, A. Persico1,2, S. Abbà1, M. Rossi1, L. Galetto1, M. Vallino1, M. Turina1, C. Marzachì1

1CNR Istituto per la Protezione Sostenibile delle Piante, Torino, Italy, 2Università degli Studi di Torino, Grugliasco (TO), Italy

OC 06 Analysis of the mRNA expression of DNA damage response genes in HIV infected patients D. Di Carlo1, F. Falasca1, E. Panzini2, I. Sciandra1, L. Mazzuti1, G. Antonelli1, O. Turriziani1

1Department of Molecular Medicine “Sapienza” University of Rome, 2University Hospital Policlinico Umberto I Rome

13.00-13.50 Lunch

13.50-15.20 Session 2 VIRAL DIAGNOSIS Chairs: Saverio Parisi (Padua), Massimo Turina (Turin)

13.50-14.10 New tools and new challeges for virological diagnosis Mauro Pistello, Pisa


OC 07 3-D spheroid model to improve Human herpesvirus in vitro infection models D. Bortolotti, V. Gentili, A. Rotola, D. Di Luca, R. Rizzo Department of Medical Sciences, Section of Microbiology and Medical Genetics, University of Ferrara – Italy

OC 08 Detection of drug resistant HCV mutants observed by NGS analysis N. Clementi1, V. Caputo1, R.A. Diotti1, E. Boeri2, M. Sampaolo1, V. Amato1, R. Burioni1, N. Mancini1,2, M. Clementi1,2

1Laboratory of Microbiology and Virology, Vita-Salute San Raffaele University, Milan, Italy, 2Laboratory of Microbiology and Virology, San Raffaele Hospital, Milan, Italy.

SCIENTIFICPROGRAMME

7

OC 09 Soluble HLA-G pre-transplant levels to identify the risk for development of CMV infection in heart transplant recipients V. Gentili1, D. Bortolotti1, A. Rotola1, L. Potena2, D. Di Luca1, R. Rizzo1

1Section of Microbiology and Medical Genetics, Department of Medical Sciences, University of Ferrara, Ferrara, Italy, 2Cardiovascular Department, University of Bologna, Bologna, Italy

OC 10 Differences in circulating cell-free HPV16 DNA levels during chemio-radiotherapy for oropharyngeal cancer F. Mastrogiovanni1,2, F. Paolini1,2, A. Farneti3, L. Marucci3, R. Pellini4, M. Benevolo5, S. Falcucci1,2, C. D’Ambrosio6, A. Vidiri7, R. Covello5, G. Sanguineti3, A. Venuti1,2

1HPV-UNIT, 2Tumor Immunology and immunotherapy UOSD, 3Radiotherapy, 4ENT surgery, 5Pathology, 6Oncology, 7Radiology, IRCCS Regina Elena National Cancer Institute, Rome, Italy

OC 11 Quantitative Detection of BKV using the Real Time PCR STAT-NAT BKV assay L. Spinelli, M. Ballarini, L. Bavagnoli, A. Di Cosimo, G. Ferri, M.L. Incandela, D. Rigamonti, M. Gramegna Sentinel CH. SpA, Milano, Italy

OC 12 HCV Genotype Distribution and Association to Gender is Comparable in Patients Tested After Widening of Antiviral Treatment Criteria: Burden of HCV Infection Is Greater than Expected? M. Basso1, D. Zago1, I. Pozzetto2, M. Pacenti3, G. Brancaccio1, S. Ragolia1, G. Palù1, S.G. Parisi1

1Department of Molecular Medicine, University of Padova, Italy, 2Department of Public Health and Infectious Diseases, Sapienza University of Rome, Italy, 3Microbiology and Virology Unit, Padova University Hospital, Italy

15.20-16.50 Session 3 HUMAN VIRAL DISEASES Chairs: Davide Gibellini (Verona), Enzo Tramontano (Cagliari)

15.20-15.40 Torquetenovirus: the human virome from bench to bedside Fabrizio Maggi, Pisa


OC 13 Non-primary HCMV infection: natural history and immune response D. Cirasola1, L. Fiorina1, C. Achille2, A. Arossa3, A. Spinillo3, M.G. Revello1, D. Lilleri1

1U.O.C. Laboratorio Genetica-Trapiantologia e Malattie Cardiovascolari, IRCCS Policlinico S. Matteo, Pavia, 2Neonatologia e Terapia Intensiva Neonatale, IRCCS Policlinico S. Matteo, Pavia, 3Ostetricia e Ginecologia, IRCCS Policlinico S. Matteo, Pavia

OC 14 Tracing the first HIV-1 epidemics in the Milan area A. Lai1, A. Bergna1, G. Zehender1, A. Giacomelli1, M. Ciccozzi2, C. Balotta1, M. Galli1

1Department of Biomedical and Clinical Sciences “Luigi Sacco”, University of Milan, Milan, Italy, 2Unit of Clinical Pathology and Microbiology, University Campus Bio-Medico of Rome, Rome, Italy

OC 15 Hepatitis B “e” Antigen levels vary according to different phases of HBV infection, can contribute to estimate HBV replicative potential and to predict therapeutic outcome in HBeAg-positive patients L. Piermatteo1, R. Salpini1, M. Alkhatib1, M. Aragri1, A. Bertoli1, A. Iuvara2, M. De Cristofaro3, G. Cappiello3, C. Cerva4, C. Minichini5, M. Pisaturo5, M. Starace5, N. Coppola5, A. Spanò3, L. Sarmati4, M. Andreoni4, M. Angelico6, S. Grelli1,2, F. Ceccherini Silberstein1, C.F. Perno7, V. Svicher1

1University of Rome “Tor Vergata”, Department of Experimental Medicine, Rome, Italy, 2University Hospital of Rome “Tor Vergata”, Microbiology and Virology Unit, Rome, Italy, 3”Sandro Pertini” Hospital, Microbiology Unit, Rome, Italy, 4University Hospital of Rome “Tor Vergata”, Infectious Disease Unit, Rome, Italy, 5University of Campania “Luigi Vanvitelli”, Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, Naples, Italy, 6University Hospital of Rome “Tor Vergata”, Hepatology Unit, Rome, Italy, 7University of Milan, Department of Oncology and Haemato-oncology, Milan, Italy

OC 16 Viral infections contribute to IL-8 overexpression in children with Biliary Atresia F. Parolini1, M. Traversi2, S. Roversi2, R. Pezzotta2, A. Zani2, F. Filippini2, D. Alberti1, A. Caruso2, S. Fiorentini2

1Department of Pediatric Surgery, Civic Hospital Brescia, University of Brescia, Brescia, Italy, 2Section of Microbiology, Department of Molecular and Translational Medicine, University of Brescia Medical School, Brescia, Italy

OC 17 HCMV non-primary infection during pregnancy D. Lilleri1, P. Zelini1, L. Fiorina1,5, M. De Cicco1, D. Cirasola1, C. Achille2, V. Marazzi3, A. Sarasini4, G. Muscettola3, A. Spinillo3

1U.O.C. Laboratorio Genetica-Trapiantologia e Malattie Cardiovascolari, IRCCS Policlinico S. Matteo, Pavia, 2Neonatologia e Terapia Intensiva Neonatale, IRCCS Policlinico S. Matteo, Pavia, 3Ostetricia e Ginecologia, IRCCS Policlinico S. Matteo, Pavia, 4Microbiologia e Virologia, IRCCS Policlinico S. Matteo, Pavia, 5Scuola di Specialità Microbiologia e Virologia, Università degli Studi di Pavia

SCIENTIFICPROGRAMME

8

OC 18 Lineage 1 and 2 West Nile Virus infection equally affect the IFN response and dendritic cells maturation F. Frasca1, M. Statzu1, A. Pierangeli1, L. Santinelli1, M. Scordio1, C. Nonne1, A. Sgrigna1, B. Caputo3, L. Vitiello4, M. Gentile1, E. Riva5, G. Antonelli1,2, C. Scagnolari1

1Laboratory of Virology, Department of Molecular Medicine, affiliated to Istituto Pasteur Italia – Cenci Bolognetti Foundation, Sapienza University of Rome, Rome, Italy, 2Microbiology and Virology Unit, Sapienza University Hospital, Rome, Italy, 3Parasitology Unit, Department of Public Health and Infectious Diseases, ‘Sapienza’ University of Rome, Italy, 4Laboratory of Pathophysiology of Cachexia and Metabolism of Skeletal Muscle, IRCCS San Raffaele Pisana, Rome, Italy, 5Unit of Virology, Campus Bio-Medico University Hospital, Rome, Italy

16.50-17.30 Transfer to Palazzo Bo’ Chair: Maria Cristina Parolin (Padua)

17.30-18.00 Welcome addresses from the Rector of the University of Padova Rosario Rizzuto, Padua

18.00 The Future of Virology Giorgio Palù, Padua

Welcome reception

WEDNESDAY, SEPTEMBER 1109.00-10.30 Session 4 ENVIRONMENTAL AND PLANT VIROLOGY Chairs: Beatriz Navarro (Bari), Luisa Rubino (Bari)

09.00-09.20 Diversity of DNA and RNA viruses in extreme polar environments Antonio Alcamí, Madrid


OC 19 CryoEM atomic structure of potato virus X A. Grinzato1, E. Kandiah2, C. Lico3, C. Betti3, S. Baschieri3, G. Zanotti1

1Department of Biomedical Science, University of Padova, Padova, Italy, 2Structural Biology Group, European Synchrotron Radiation Facility, Grenoble, France, 3Laboratory of Biotechnology, ENEA C.R. Casaccia, Roma, Italy

OC 20 Beneficial viruses to protect plants from biotic and abiotic stress: a holistic approach M. Turina, M. Chiapello, C. Marzachì, S. Abbà, L. Galetto, S. Ottati, M. Vallino, G. Martino, M. Forgia, M. Ciuffo Institute for Sustainable Plant Protection, CNR, Torino, Italy

OC 21 NGS approaches to characterize mycovirus-induced Ochratoxin A regulation in Aspergillus ochraceus M. Forgia2,3, L. Nerva1,2, M. Chiapello2, G.C. Varese3, M. Turina2

1Council for Agricultural Research and Economics - Research Centre for Viticulture and Enology CREA-VE, Coneglinao (TV), 2Institute for Sustainable Plant Protection, CNR, Torino, Italy, 3Mycotheca Universitatis Taurinensis (MUT), Department of Life Sciences and Systems Biology, University of Turin, Torino, Italy

OC 22 Phage therapy to control bacterial diseases of plants G. Martino, M. Vallino, M. Turina, M. Ciuffo Istituto per la Protezione Sostenibile delle Piante, CNR, Torino

OC 23 Presence of Norovirus and Hepatitis A in Berries R. Čobanović1, K. Mihajlović1, B. Kokić2

1Microbiological department, SP Laboratory, Bečej, Serbia, 2Research center for feed technology and animal products, University of Novi Sad Institute of food technology in Novi Sad, Serbia

OC 24 Occurrence of Human Salivirus in untreated wastewaters in Italy P. Mancini1, G. Bonanno Ferraro1, M. Iaconelli1, E. Suffredini2, C. Veneri1, G. La Rosa1

1Department of Environment and Health - Istituto Superiore di Sanità, Rome, Italy, 2Department of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, Rome, Italy

10.30-10.45 Coffee break

SCIENTIFICPROGRAMME

9

10.45-13.00 Session 5 ANTIVIRAL THERAPY Chairs: Saverio Parisi (Padua), Maurizio Zazzi (Siena)

10.45-11.05 New molecular based antiviral therapy Stuart Le Grice, Frederick

11.10-11.30 2DR: from opportunity to change of paradigm Andrea Antinori, Rome

11.35-11.55 Does one size fit all? Antonella Castagna, Milan


OC 25 Maraviroc as a Latency Reversing Agent in cell line models I. Vicenti1, F. Dragoni1, M. Monti2,4, A. Giannini1, A. Ciabattini1, B. Rossetti3, A. De Luca1,3, D. Medaglini1, E. Montomoli2,4, M. Zazzi1

1Department of Medical Biotechnologies, University of Siena, Siena, Italy, 2Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy, 3Infectious Diseases Unit, Azienda Ospedaliera Universitaria Senese, Siena, Italy, 4VisMederi srl, Siena, Italy

OC 26 Inhibition of HCMV replication by small molecules interfering with the dimerization of DNA polymerase processivity factor UL44 H. Ghassabian1, M. Timmoneri1, V. Di Antonio1, F. Falchi2, B. Mercorelli1, A. Loregian1, G. Palù1, G. Alvisi1

1Department of Molecular Medicine, University of Padua, Italy, 2Italian Institute of Technology, Genova, Italy

OC 27 Evaluation of broad-spectrum antivirals targeting viral envelopes of Dengue and Zika viruses A. Boccuto1, A. Brai2, F. Saladini1, N. Palombi2, I. Vicenti1, C. Ardino2, M. Zazzi1, M. Botta2

1Department of Medical Biotechnologies, University of Siena, Italy, 2Department of Biotechnologies, Chemistry and Pharmacy, University of Siena, Italy

OC 28 Impact of DAA mediated HCV eradication on sCD163 and sCD14 systems in LOW and HIGH fibrosis HCV monoinfected patients P. Nijhawan, C. Mascia, S. Vita, I. Pozzetto, B. Kertusha, L. Fondaco, F. Mengoni, R. Marocco, C. Mastroianni, M. Lichtner S.M. Goretti Hospital, Latina, Policlinico Umberto I, Sapienza University of Rome

OC 29 The war against paramyxoviruses: new and potent hemagglutinin- neuraminidase inhibitors of Newcastle Disease Virus P. Rota1,2, P. La Rocca3, F. Bonfante4, M. Montefiori5, M. Pagliari4, P. Allevi1, L. Anastasia2,3

1Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan (Italy); 2Laboratory of Stem Cells for Tissue Engineering, IRCCS Policlinico San Donato, San Donato Milanese, Milan (Italy); 3Department of Biomedical Sciences for Health, University of Milan, Segrate, Milan (Italy); 4Division of Comparative Biomedical Sciences, Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Italy; 5Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen (Denmark)

OC 30 Combining innate immune and epigenetic modulators to reactivate latent HIV-1 reservoirs E. Palermo1, C. Acchioni2, D. Di Carlo3, A. Zevini1, M. Muscolini1, M. Ferrari1, L. Castiello1, S. Virtuoso4, A. Borsetti4, G. Antonelli3, O. Turriziani3, M. Sgarbanti2, J. Hiscott1

1Pasteur Institute - Italy, Istituto Pasteur - Fondazione Cenci Bolognetti, Rome, Italy, 2Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Rome , Italy, 3Department of Molecular Medicine, “Sapienza” University of Rome, Rome, Italy, 4National HIV/AIDS Research Center, Istituto Superiore di Sanità, Rome, Italy

13.00-14.00 LUNCH AND POSTER VIEWING

14.00-15.00 ROUND TABLE “ANIMAL TESTING IN TODAY’S VIROLOGICAL RESEARCH” Chair: Edward Mocarski (Atlanta)

Small animals in virological research Paolo Bonaldo, Padua

Animal testing for the study of virus-host relationships Guido Silvestri, Atlanta

Animal testing in the study of veterinary virology Maria Serena Beato, Legnano PD

SCIENTIFICPROGRAMME

10

15.00-16.30 Session 6 VETERINARY VIROLOGY Chairs: Maria Serena Beato (Legnaro PD), Canio Buonavoglia (Bari)

15.00-15.20 Emerging Lyssaviruses in the EU and public health associated risks Paola De Benedictis, Legnaro PD

15.30-16.30 Oral communications OC 31 Canine Distemper Outbreaks in Alpine Wildlife T. Trogu, S. Canziani, A. Bianchi, I. Bertoletti, L. Alborali, C. Salogni, F. Paterlini, A. Gaffuri, E. Sozzi, D. Lelli, A. Lavazza, A. Moreno Istituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia Romagna “Bruno Ubertini”, Brescia (Italy)

OC 32 Skin lesions in wildlife ruminants from Stelvio national park: co-infections with epitheliotropic viruses L. Gallina1, F. Savini1, G. Casà1, I. Bertoletti2, A. Bianchi2, A. Lavazza2, A. Scagliarini1

1Department of Veterinary Medical Sciences, Alma Mater Studiorum, Università di Bologna, 2Istituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia-Romagna, Brescia

OC 33 GII norovirus in swine faecal samples in Northern Italy: identification of two different genotypes L. Cavicchio1, G. Rizzo1, G. Cunial1, L. Tassoni1, A. Milani1, A. Laconi1, M. Campalto1, M. Pagliari1, M. Ustulin1, I. Monne1, M. Forzan2, M. Mazzei2, D. Vio1, L. Bonfanti1, M.S. Beato1

1Istituto Zooprofilattico Sperimentale delle Venezie, (IZSVe), Legnaro (Padova), Italy, 2Università di Pisa, Veterinary Sciences Department, Pisa, Italy

OC 34 Surveillance among orthomyxoviruses (IAV, IBV, ICV, IDV) in Italy (2014-2018) A. Prosperi1, S. Faccini1, M. Merenda1, A. Amorico1, A. Moreno1, C. Rosignoli1, E. Pariani2, C. Galli2, P. Affanni3, M.E. Colucci3, E. Foni1, A. Luppi1, C. Chiapponi1

1Istituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia Romagna, Italy, 2Dipartimento di Scienze Biomediche per la Salute, Università di Milano, Milan, Italy, 3Dipartimento di Medicina e Chirurgia, Università di Parma, Parma, Italy

OC 35 Whole genome phylodynamics of Dolphin morbillivirus from the Mediterranean Sea F. Cerutti1, F. Giorda1, A. Pautasso1, C. Grattarola1, W. Mignone1, N. Keck2, A. Lorusso3, G. Di Francesco3, G. Di Guardo4, M. Goria1, L. Masoero1, P. L. Acutis1, C. Casalone1, S. Peletto1

1Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d’Aosta, Torino, Italy, 2Laboratoire départemental vétérinaire de Herault, Montpelliere, France, 3Istituto Zooprofilattico Sperimentale dell’Abruzzo e del Molise “G. Caporale”, Teramo, Italy, 4Università degli Studi di Teramo, Teramo, Italy

OC 36 A/H1N1pdm(09) in a turkey breeder flock: occurrence of reverse zoonosis F. Gobbo1, A. Bortolami1, B. Zecchin1, A. Fusaro2, A. Pastori2, G. Zamperin2, I. Monne2, C. Terregino1,2

1Istituto Zooprofilattico Sperimentale delle Venezie, SCS6 Laboratorio di Virologia Speciale e Sperimentazione, 2Istituto Zooprofilattico Sperimentale delle Venezie, SCS5 Ricerca e Innovazione

16.30-18.00 Session 7 EMERGING VIRUSES AND ZOONOSES Chairs: Maria Carla Re (Bologna), Alessandra Scagliarini (Bologna)

16.30-16.50 Emerging vector-borne viruses in humans and animals: the Africa - Europe connection Marietjie Venter, Pretoria


OC 37 The prevalence of HEV in wild boar in Campania C. Esposito, M.G. Amoroso, F. Alfano, B. Cioffi, M. Viscardi, M. Levante, A.S. Giacca, N. D’Alessio, G. Galiero, G. Fusco Istituto Zooprofilattico Sperimentale del Mezzogiorno - Dipartimento di Sanità Animale

OC 38 Distribution and characterization of zoonotic Hepatitis E virus in wild ungulates hunted in North-Eastern Italy F. Obber1, B. Zecchin1, A. Schivo1, L. Bellinati1, A. Milani1, A. Fusaro1, L. Ceglie1, A. Natale1, L. Bonfanti1, L. Amato1, G. Cunial1, M. Bregoli1, C. Salata2, S. Ragolia2, G. Palù2, M.T. Giordani3, M. Barbujani1, V. Giovannini1, M. L. Menandro4, M. Martini4, P. Mulatti1, I. Monne1, C.V. Citterio1

1Istituto Zooprofilattico Sperimentale delle Venezie (IZSVe) – Legnaro (Italy), 2Department of Molecular Medicine, University of Padova – Padova (Italy), 3Department of Infectious and Tropical Diseases, St. Bortolo Hospital, Vicenza (Italy), 4Department of Animal Medicine, Production and Health, University of Padova – Padova (Italy)

SCIENTIFICPROGRAMME

11

OC 39 Mammalian Orthoreovirus (MRV) at the interface between bat, pigs and humans S. Leopardi1, P. Priori2, L. Cavicchio3, G. Zamperin1, M.S. Beato3, P. De Benedictis1

1Istituto Zooprofilattico Sperimentale delle Venezie SCS5 Ricerca e innovazione, 2S.T.E.R.N.A., 3Istituto Zooprofilattico Sperimentale delle Venezie, SCT3, Laboratorio di virologia diagnostica

OC 40 A conserved serine on Ebolavirus VP35 is required for replication activity but not antagonist function M.J. Morwitzer1, A. Corona2, L. Zinzula3, E. Fanunza2, C. Vornholt1, C.F. Basler4, E. Tramontano2,5, S.P. Reid1

1Department of Pathology and Microbiology, Nebraska Medical Center, Omaha, USA, 2Department of Life and Environmental Sciences University of Cagliari, Monserrato, Italy, 3Department of Molecular Structural Biology, The Max-Planck Institute of Biochemistry, Martinsried, Germany, 4Center for Microbial Pathogenesis, Institute for Biomedical Sciences, Georgia State University, Atlanta, USA, 5Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Monserrato, Italy

OC 41 Elevated plasma level of IP-10 /CXCL10 is correlated with severity of human West Nile virus (WNV) infection G. Rossini1, S. Varani2, S. Morini1, S. Silenzi2, MC Re1,2

1Unit of Clinical Microbiology, Regional Reference Centre for Microbiological Emergencies (CRREM), St. Orsola-Malpighi University Hospital, Bologna, Italy, 2Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Italy

OC 42 The persistent infection of tick cells by Hazara orthonairovirus is mediated by virus-derived DNA forms M.V. Salvati1, C. Del Vecchio1, L. Bell-Sakyi2, C. Parolin1, A. Calistri1, G. Palù1, A. Mirazimi3,5, C. Salata1

1Department of Molecular Medicine, University of Padova, Italy, 2The Tick Cell Biobank, Institute of Infection and Global Health, University of Liverpool, UK, 3Department of Microbiology, Public Health Agency of Sweden, Solna, Sweden, 4Department for Laboratory Medicine, Karolinska Institute, Huddinge/Stockholm, Sweden, 5National Veterinary Institute, Uppsala, Sweden

18.00-18.45 Oral Presentation of Selected Posters and Best Poster Awards Chairs: Giorgio Palù (Padua), Maria Cristina Parolin (Padua)

18.45 SIV-ISV General Member Meeting

THURSDAY, SEPTEMBER 1209.00-10.50 Session 8 INFECTION & IMMUNITY AND VACCINOLOGY Chairs: Arnaldo Caruso (Brescia), Rossana Cavallo (Turin)

09.00-09.20 Type I Interferon in viral infections: a reconsideration of its role 60 years after the discovery Guido Antonelli, Rome

09.25-09.45 Post-treatment vaccination for HPV-related diseases Franco Buonaguro, Naples


OC 43 The efficacy of CMV specific immune reconstitution is highly dependent on donor/recipient serostatus and type of solid organ transplanted D. Abate1, A. Saldan1, C. Mengoli1, D. Sgarabotto3, M. Alessi4, A. Gambino7, L. Bonfante4, P. Burra6, F. Marchini4, B. Rossi4, P. Boccagni6, A. Pompea Frajese7, G. Toscano7, S. Fasolato4, C. Silvestre6, F.P. Russo6, P. Angeli4, L. Furian6, M. Loy6, G. Sturniolo6, U. Cillo6, G. Gerosa7, P. Rigotti6, F. Rea6, G. Palù1

1Department of Molecular Medicine, 2Department of Cardiac, 3Transplant infectious diseases, 4Nephrology unit 1, 5Thoracic and Vascular Sciences Unit, 6Department of surgical oncology and gastroenterology, 7Cardiothoracic surgery General Hospital, Italy

SCIENTIFICPROGRAMME

12

OC 44 Toscana virus NSs protein acts as E3 Ubiquitin ligase promoting RIG-I degradation G. Gori Savellini, G. Anichini, C. Gandolfo, S. Prathyumnan, M.G. Cusi Department of Medical Biotechnologies, University of Siena, Siena, Italy

OC 45 Neutralizing sera from HSV-1 or HSV-2 infected subjects poorly inhibit direct virus cell-to-cell spread E. Criscuolo1, M. Castelli1, R.A. Diotti1, V. Amato1, R. Burioni1, M. Clementi1,2, A. Ambrosi3, N. Mancini1,2, N. Clementi1

1Laboratory of Microbiology and Virology, “Vita-Salute” San Raffaele University, Milan, Italy, 2Laboratory of Microbiology and Virology, San Raffaele Hospital, Milan, Italy, 3Faculty of Medicine and Surgery, “Vita-Salute” San Raffaele University, Milan, Italy

OC 46 HIV-1 and HLA-C relationship: a matter of stability D. Zipeto1, S. Mutascio1, C. Stefani1, M. Serena1, F. Parolini1, S. Fochi1, M.G. Romanelli1, D. Gibellini2

1Department of Neuroscience, Biomedicine and Movement Sciences, 2Department of Diagnostics and Public Health, School of Medicine, University of Verona, Italy

OC 47 Modulation of macrophage subsets by African Swine Fever virus strains of diverse virulence G. Franzoni1, E. Razzuoli2, S.P. Graham3, T. Carta1,4, G. Galleri5, S. Zinellu1, P. Angioi1, P. Modesto2, S. Dei Giudici1, A. Oggiano1

1Istituto Zooprofilattico Sperimentale della Sardegna, Sassari, Italy, 2Istituto Zooprofilattico Sperimentale della Liguria, Piemonte e Valle d’Aosta, Sezione di Genova, Italy, 3The Pirbright Institute, Pirbright, United Kingdom, 4Università degli Studi di Sassari, Dipartimento di Medicina Veterinaria, Sassati, Italy, 5Università degli Studi di Sassari, Dipartimento di Immunologia Clinica e Sperimentale, Sassari, Italy

10.50-11.05 Coffee break

11.05-13.00 Session 9 VIRAL GENETICS AND BIOTECHNOLOGY Chairs: Elisabetta Affabris (Rome), Antonina Dolei (Sassari)

11.05-11.25 Gene therapy of genetic disorders Alessandra Biffi, Padua

11.30-11.50 Neurodegeneration and human endogenous retroviruses Antonina Dolei, Sassari


OC 48 Functional characterization of the recombinant HERV-K (HML-2) integrase expressed in E. coli and its interaction with HIV-1 sequences and inhibitors F. Esposito1, N. Grandi1, L. Wenxue2, E. Fanunza1, N. Avindra2, E. Tramontano1

1Department of Life and Environmental Sciences, University of Cagliari; 2National Institute of Neurological Disorders and Stroke, NIH Neurological Institute, Bethesda, MD

OC 49 Molecular and antigenic properties of Theileria parva antigen 9 expressed in mammalian cells V. Franceschi1, R.G. Bastos2, F. Macchi1, L. Russo1, G. Tebaldi1, T. Connelley3, I. Morrison3, D. P. Knowles2, L.M. Fry2, G. Donofrio1

1Department of Medical-Veterinary Science, University of Parma, Parma, Italy, 2Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA, United States, 3Royal School of Veterinary Sciences, The Roslin Institute, University of Edinburgh, Edinburgh, United Kingdom

OC 50 A new NGS approach for Small Ruminant Lentivirus full genome characterization B. Colitti1, E. Coradduzza2, G. Puggioni2, M.T. Capucchio1, R. Reina3, L. Bertolotti1, S. Rosati1

1University of Turin, Dept. Veterinary Science, Grugliasco, Torino, Italy, 2Istituto Zooprofilattico Sperimentale della Sardegna, Sassari, Italy, 3Institute of Agrobiotechnology (CSIC-UPNA-Government of Navarra), Navarra, Spain

OC 51 Study of genetic evolution of RHDV2 from 2011 to today and detailed mapping of key antigenic determinants P. Cavadini, G. Campisi, A. Vismara, A. Lavazza, L. Capucci Istituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia Romagna

OC 52 Comparative analysis of the complete genome sequences of Sardinian African swine fever virus isolates (1978-2014) C. Torresi1, M. Fiori2, L. Bertolotti3, M. Floris5, B. Colitti3, M. Giammarioli1, S. Dei Giudici2, A. Oggiano2, M. Malmberg4, G.M. De Mia1, S. Belák4, F. Granberg4

1Istituto Zooprofilattico Sperimentale dell’Umbria e delle Marche, Perugia, Italy, 2Istituto Zooprofilattico Sperimentale della Sardegna, Sassari, Italy, 3Dipartimento di Scienze Veterinarie, Università degli Studi di Torino, Grugliasco, Torino, Italy, 4Swedish University of Agricultural Sciences, Uppsala, Sweden, 5Dipartimento di Scienze Veterinarie, Università degli Studi di Sassari, Sassari, Italy

SCIENTIFICPROGRAMME

13

OC 53 Genetic diversity of small ruminant lentivirus (SRLV) isolates in Italy M. Bazzucchi, I. Pierini, S. Pirani, P. Gobbi, C. Torresi, M. Giammarioli, F. Feliziani, G.M. De Mia Istituto Zooprofilattico Sperimentale dell’Umbria e delle Marche “Togo Rosati”, Perugia, Italy

13.00-14.00 LUNCH AND POSTER VIEWING

14.00-16.00 Session 10 VIRAL ONCOLOGY AND PATHOGENESIS Chairs: Lawrence Banks (Trieste), Aldo Venuti (Rome)

14.00-14.20 HTLV-1: the neglected and yet most oncogenic human pathogen Roberto Accolla, Varese

14.25-14.45 Human Papilloma viruses: from infectious entry to malignancy Lawrence Banks, Trieste

14.50-15.10 Herpesvirus Subversion of Apoptosis and Necroptosis Host Defense Pathways

Edward Mocarski, Atlanta


OC 54 The dimeric form of high-risk HPV E6 oncoprotein sustains keratinocyte transformation through a p53-independent mechanism L. Messa1, M. Celegato1, B. Mercorelli1, C. Bertagnin1, G. Alvisi1, L. Banks2, G. Palù1, A. Loregian1

1Department of Molecular Medicine, University of Padova, Padova, Italy, 2International Centre for Genetic Engineering and Biotechnology, Trieste, Italy

OC 55 Cancer diagnosis in HIV infected patients: a 13 years observational study M. Basso1, E. Forlin1, M.C. Rossi2, S. Panese3, D. Zago1, I. Pozzetto4, C. Stagni1, B. Parisini1, G. Palù1, S.G. Parisi1

1Department of Molecular Medicine, University of Padova, Padova, Italy, 2Infectious Disease Unit, treviso Hospita, Treviso, Italy, 3Infectious Disease Unit, dell’Angelo Hospital, Venezia, Italy, 4University La Sapienza, Roma

OC 56 Modulation of type I interferon system by African Swine Fever virus E. Razzuoli1, G. Franzoni2, I. Ferretti1, S. Zinellu2, G. Galleri3, T. Carta4, M. Amadori5, S. Dei Giudici2, P. Modesto1, A. Oggiano2

1Istituto Zooprofilattico Sperimentale della Liguria, Piemonte e Valle d’Aosta, Sezione di Genova, 2Istituto Zooprofilattico Sperimentale della Sardegna, Sassari, 3Università degli Studi di Sassari, Dipartimento di Immunologia Clinica e Sperimentale, 4Università degli Studi di Sassari, Dipartimento di Medicina Veterinaria, 5Istituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia Romagna, Brescia

OC 57 The antiviral effect of retrocyclin 101 against Zika virus W. Wang1,2, W. Lu2, A. Garzino Demo2,3

1Wuhan Institute of Virology, Wuhan, 2Institute of Human Virology, University of Maryland School of Medicine, Baltimore, USA, 3Department of Molecular Medicine, University of Padova, Italy

THE NOBEL LECTURE IN VIROLOGY Chair: Giorgio Palù (Padua)

16.00 Infectious plasmidosis: a novel class of human pathogens Harald zur Hausen, Nobel laureate in Medicine 2008

Luria and Viruses Awards Chairs: Arianna Calistri (Padua), Giorgio Palù (Padua)

Closing Remarks and ECM Questionnaires

SCIENTIFICPROGRAMME

14

ANTIVIRAL THERAPY P 01 Potent and broad-spectrum cycloheptathiophene-3-carboxamide compounds that target the PA-PB1 interaction of influenza virus RNA polymerase and possess a high barrier to drug resistance G. Nannetti1, S. Massari2, B. Mercorelli1, C. Bertagnin1, J. Desantis2, O. Tabarrini2, G. Palù1, A. Loregian1

1Department of Molecular Medicine, University of Padua, Padua, Italy, 2Department of Pharmaceutical Sciences, University of Perugia, Perugia, Italy

P 02 Development of new antiviral compounds to combat influenza viruses C. Bertagnin1, G. Nannetti1, I. D’Agostino2, S. Schenone3, M. Botta2, P. Zhan4, G. Palù1, A. Loregian1

1Department of Molecular Medicine, University of Padova, Padova, Italy, 2Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Siena, Italy, 3Department of Pharmacy, University of Genova, Genova, Italy, 4Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, Shandong, P.R. China

P 03 Evaluation of antiviral activity and resistance profile of sofosbuvir against West Nile Virus in vitro F. Dragoni, A. Boccuto, A. Giannini, F. Saladini, M. Zazzi, I. Vicenti Department of Medical Biotechnologies, University of Siena, Siena

P 04 A survey as a chance of education on U=U in PLWHIVA G. Orofino1, S. Patrucco2, G.L. Cipero2, A. Perziano2, C. Owen2, P. Altini3, M. Gay4, R. Angilletta5

1Infettivologo Malattie Infettive e Tropicali Ospedale Amedeo di Savoia di Torino, Associazione Arcobaleno AIDS Torino, 2Associazione Arcobaleno AIDS Torino, 3Coordinatore Corso di Laurea in Infermieristica Torino, Associazione Arcobaleno AIDS Torino, 4CTSI Ospedale Sant’Antonio e Biagio di Alessandria, 5Malattie Infettive, Clinica Universitaria di Torino

P 05 Generation of combinatorial lentiviral vectors expressing multiple anti hepatitis C virus shRNAs and their validation on a novel HCV replicon double reporter cell line A. Vitiello, F. Ciccaresce, V. Di Antonio, H. Ghassabian, E. Franchin, C. Parolin, G. Palù, C. Salata, A. Calistri, G. Alvisi Department of Molecular Medicine, University of Padova

P 06 Impact of RAMs selected by older NNRTI on the susceptibility to doravirine in vitro F. Saladini1, F. Giammarino1, A. Giannini1, A. Boccuto1, F. Dragoni1, I. Vicenti1, R. W. Shafer2, M. Zazzi1

1Department of Medical Biotechnologies, University of Siena, Siena, Italy, 2Stanford University, Stanford, CA, USA

P 07 Pilot study of HIV-1 blood persistence measured as the different viral DNA species in mono and dual therapy regimens C. Orlandi1, B. Canovari2, Z. Pasquini2,3, F. Barchiesi2,3, A. De Maria4, M. Magnani1, A. Casabianca1

1Dipartimento di Scienze Biomolecolari, Sezione di Biotecnologie, Università di Urbino “Carlo Bo”, 2Malattie Infettive, Azienda Ospedaliera Ospedali Riuniti Marche Nord Pesaro, 3Dipartimento di Scienze Biomediche e Sanità Pubblica, Università Politecnica delle Marche, Clinica Malattie Infettive Ospedali Riuniti di Ancona, 4Center for Excellence in Biomedical Research, University of Genova

EMERGING VIRUSES AND ZOONOSES P 08 Rescue of replication-competent ZIKV hidden in placenta-derived mesenchymal cells long after the resolution of the infection V. Bordoni1, E. Lalle1, F. Colavita1, A. Baiocchini1, R. Nardacci1, L. Falasca1, F. Carletti1, E. Cimini1, L. Bordi1, G. Kobinger2, V. D’Ambrosio3, F. Natale3, A. Giancotti3, L. Manganaro3, F. Del Nonno1, A. Zumla4, G. Liuzzi1, G. Ippolito1, M.R. Capobianchi1, C. Agrati1, C. Castilletti1

1National Institute for Infectious Diseases “L. Spallanzani”, IRCCS, Rome, Italy, 2University of Manitoba, Winnipeg, Manitoba, Canada, 3”Sapienza” University of Rome, Policlinico Umberto I Hospital, Rome, Italy, 4University College London, London, UK

P 09 Porcine circovirus 3 (PCV-3) detection in wild ungulates and associated ticks in Friuli Venezia Giulia L. Grassi, G. Franzo, C.M. Tucciarone, M. Legnardi, D. Pasotto, M. Cecchinato, M. Martini, M. Drigo, M.L. Menandro Università degli Studi di Padova, Dipartimento di Medicina Animale, Produzioni e Salute (MAPS)

ENVIRONMENTAL AND PLANT VIROLOGY P 10 Occurrence of enteric viruses and free-living amoebae in swimming pools and spa L. Bonadonna, R. Briancesco, A.M. Coccia, G. Bonanno Ferraro, P. Mancini, C. Veneri, S. Della Libera, M. Iaconelli, R. Paradiso, G. La Rosa Department of Environment and Health - Istituto Superiore di Sanità, Rome, Italy

POSTER

15

P 11 Saffold Virus: first detection of a human Cardiovirus in raw sewage in Italy G. Bonanno Ferraro1, P. Mancini1, E. Suffredini2, M. Iaconelli1, C. Veneri1, G. La Rosa1


P 12 Pepper mild mottle virus in water environments in Italy: a potential new water quality indicator? M. Iaconelli1, G. Bonanno Ferraro1, P. Mancini1, E. Suffredini2, C. Veneri1, L. Bonadonna1, G. La Rosa1


P 13 Replacement of Hepatitis A virus strains circulating in Campania Region (2015-2018) assessed through sentinel bivalves and environmental surveillance E. Suffredini1, P. Mancini2, M. Iaconelli2, G. Bonanno Ferraro2, D. De Medici1, T. Vincenza1, Y.T.R. Proroga3, C. Veneri2, M. Della Rotonda4, G. La Rosa2

1Department of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, Rome, Italy, 2Department of Environment and Health - Istituto Superiore di Sanità, Rome, Italy, 3Department of Food Microbiology, Istituto Zooprofilattico Sperimentale del Mezzogiorno, Portici, NA, Italy, 4Campania Region

P 14 Environmental surveillance of Hepatitis E virus in Italy M. Iaconelli1, G. Bonanno Ferraro1, P. Mancini1, E. Suffredini2, D. De Medici2, S. Della Libera1, F. Bignami1, C. Veneri1, A.R. Ciccaglione3, R. Bruni3, S. D’Amato4, G. La Rosa1

1Department of Environment and Health - Istituto Superiore di Sanità, Rome, Italy, 2Department of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, Rome, Italy, 3Department Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy, 4Ministry of Health, Italy

P 15 Carnation Italian ringspot virus p36 protein expression in Saccharomyces cerevisiae induces changes in mitochondrial function L. Rubino1, G. Petrosillo2, A. Antonacci1, D. Marzulli2, G. Dipace3, S. Giannattasio2

1CNR, Istituto per la Protezione Sostenibile delle Piante, UOS Bari, 2CNR, Istituto di Biomembrane, Bioenergetica e Biotecnologie Molecolari, Bari, 3Dipartimento diBioscienze, Biotecnologie e Biofarmaceutica, Università degli Studi di Bari “Aldo Moro”

P 16 Role of RNA silencing in triggering the initial molecular lesion of viroid pathogenesis B. Navarro1, S. Delgado2, A. De Stradis1, P. Serra2, R. Flores2, F. Di Serio1

1Istituto per la Protezione Sostenibile delle Piante (CNR), Bari, Italy, 2Instituto de Biología Molecular y Celular de Plantas (CSIC-UPV), Valencia, Spain

P 17 A novel emaravirus from Jujube trees (Ziziphus jujuba Mill) C. Yang1, S. Zhang2,3, T. Han1, J. Fu1, F. Di Serio4, M. Cao2,3

1Liaoning Key Laboratory of Urban Integrated Pest Management and Ecological Security, College of Life Science and Engineering, Shenyang University, Dadong, Shenyang, Liaoning, China, 2National Citrus Engineering and Technology Research Center, Citrus Research Institute, Southwest University, Beibei, Chongqing, China, 3Academy of Agricultural Sciences Southwest University, Beibei, Chongqing, China, 4Istituto per la Protezione Sostenibile delle Piante, Consiglio Nazionale delle Ricerche, Bari, Italy

P 18 Cannabis cryptic virus engineering: protocol development for dsRNA based viral vector M. Dall’Ara1, N. Miotti2, D. Baldo1, M. Calassanzio1, R. Paris3, P. Casati2, C. Ratti1

1DISTAL - Plant Pathology - University of Bologna, Bologna, Italy, 2Department of Agricultural and Food Sciences - Production, Landscape, Agroenergy - University of Milan, Milan, Italy, 3Council for Agricultural Research and Economics - Research Centre for Cereal and Industrial Crops, Bologna, Italy

HUMAN VIRAL DISEASES P 19 Unusual airborne GII.Pc_GII.3 Norovirus outbreak occurring in a theatre T. Gallo1,6, G. Degani1, A. Pischiutti1, S. Miceli1, B. Cerno1, S. Assunta2, M. Screm2, A. Arzese2, A. Savoia1, M. Di Fant1, P. D’Agaro3, I. Caracciolo3, L. Segat3, E. Ramon4, D. Giugno4, A. Lettini4, E. Suffredini5, E. Mazzolini4,6

1Azienda Sanitaria Universitaria Integrata di Udine, Dipartimento di Prevenzione, 2Azienda Sanitaria Universitaria Integrata di Udine Presidio Ospedaliero “Santa Maria della Misericordia”, 3Azienda Sanitaria Universitaria Integrata di Trieste, Igiene e Sanità Pubblica, Ospedale di Cattinara, 4Istituto Zooprofilattico Sperimentale delle Venezie, 5Istituto Superiore di Sanità, Dipartimento Sicurezza degli Alimenti, Nutrizione e Sanità pubblica Veterinaria, 6Direzione Centrale Salute, Regione Autonoma Friuli Venezia Giulia

POSTER

16

P 20 Retrospective analysis of Polyomavirus BK-associated nephropathy in kidney transplant patients from 2015 to May 2019 E. Zanotto1, I. Abbasciano2, A. Barreca3, P. Bottino1, F. Sidoti1, C. Costa1, R. Cavallo1

1AOU Città della Salute e della Scienza di Torino, SC Microbiologia e Virologia U. Torino, 2AOU Città della Salute e della Scienza di Torino, Nefrologia Dialisi e Trapianto U. Torino, 3AOU Città della Salute e della Scienza di Torino, Anatomia ed Istologia Patologica U. Torino

P 21 Prolonged viral shedding in bronchial aspirate fluids in a patients with measles-related severe pneumonia L. Bordi1, M. Antonini1, A. Bressan2, C. Castilletti1, E. Nicastri1, G. Rozera1, L. Scorzolini1, A. D’Abramo1, F. Colavita1, A. Vulcano1, A. Di Caro1, M. Maritti1, M.R. Capobianchi1, E. Lalle1

1National Institute for Infectious Diseases “L. Spallanzani”, IRCCS, Rome, Italy, 2’Sapienza’ University of Rome, Rome, Italy

P 22 Italian network for norovirus and rotavirus surveillance in health care associated infections I. Di Bartolo1, G. Ianiro1, M. Monini1, E. Pagani2, A.M. Di Pierro2, G. Giammanco3, S. De Grazia3, G.M. Rossolini4, S. Pollini4, V. Rabensteiner5, NosoVirNet group 1Department of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, Rome, Italy, 2Laboratory of Microbiology and Virology, Azienda Sanitaria dell’Alto Adige, Bolzano, Italy, 3Dipartimento di Scienze per la Promozione della Salute e Materno Infantile “G. D’Alessandro”, Università di Palermo, Palermo, Italy, 4Microbiology and Virology Unit, Florence Careggi University Hospital, Florence, Italy, 5Provincia Autonoma di Bolzano

P 23 Prevalence of non B HIV-1 subtypes in North Italy and analysis of transmission clusters based on sequence data analysis G. Lorenzin1,2, F. Gargiulo1, A. Caruso1, F. Caccuri1, E. Focà3, A. Celotti3, E. Quiros-Roldan3, F. Castelli3, M.A. De Francesco1

1Institute of Microbiology, Department of Molecular and Translational Medicine, University of Brescia-Spedali Civili, Brescia, Italy, 2Institute of Microbiology and Virology, Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy, 3Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali Civili Hospital, Brescia, Italy

P 24 Enterovirus surveillance in a Pediatric Hospital L. Coltella1, L. Piccioni1, S. Ranno1, G. Pizzichemi1, C. Auriti2, S. Chiavelli1, C. Concato1

1UOC Microbiology, Virology and Parassitology, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy, 2Neonatal Intensive Care Unit, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy

INFECTION & IMMUNITY AND VACCINOLOGY P 25 Evolution of Infectious Bronchitis Virus in the Field After Homologous Vaccination Introduction: the Italian lesson G. Franzo, M. Legnardi, C.M. Tucciarone, M. Drigo, D. Pasotto, M. Martini, L. Grassi, M.L. Menandro, M. Cecchinato Università degli Studi di Padova, Dipartimento di Medicina Animale, Produzioni e Salute (MAPS)

P 26 Advanced technologies for production of new preventive and/or therapeutic vaccines against HPV16 F. Paolini1, S. Massa2, C. Marino3, R. Franconi3, A. Venuti1

1HPV-UNIT, IRCSS Regina Elena National Cancer Institute, Rome, IT, 2Biotechnology Laboratory, Biotechnology and Agroindustry Division, 3Biomedical Technologies Laboratory, Health Technologies Division, Dept. of Sustainability, ENEA, Rome, IT

P 27 New armed HSV-1 oncolytic viruses for the immunotherapy of solid tumors A. Vitiello1, A. Reale1, V. Conciatori1, C. Parolin1, S. Piccolo1, J. Von Einem2, A. Calistri1, G. Palù1

1Department of Molecular Medicine, University of Padua, 2Insistute for Virology, University of Ulm

P 28 NKp44 expression on pDC of HIC patients associates with conserved IFNa and controlled TNFa and IL-6 production and is correlated to NKp44 modulation on NK cells F. Bozzano, F. Marras, I. Bonaccorsi, E. Pontali, L. Nicolini, A. Di Biagio, C. Dentone, G.C. Orofino, C. Cantoni, L. Moretta, G. Ferlazzo, A. De Maria University of Genova, University of Messina, Ospedale Bambin Gesu, Rome, IRCCS Policlinco San Martino Genova, Ospedali Galliera Genova, Ospedale Sanremo ASL1 Liguria, Ospedale Amedeo D’Aosta ASL 2 Torino

P 29 Herpes Simplex Virus Type 1 induced PDL-1 expression in infected murine enteric neurons safeguards viral persistence J. Conti1, M. Scarpa2, K. Andromachi2, M. Scarpa2, G. Palù1, P. Brun1, I. Castagliuolo1

1Department of Molecular Medicine, University of Padova, Italy, 2Laboratory of Advanced Translational Research, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy

POSTER

17

VETERINARY VIROLOGY P 30 Compartmentalized evolution of Bovine Viral Diarrhoea Virus type 2 in an immunotolerant persistently infected cow B. Colitti1, C. Nogarol1, M. Giacobini1, M.T. Capucchio1, I. Biasato2, S. Rosati1, L. Bertolotti1

1Department of Veterinary Science, University of Torino, Grugliasco, Torino, Italy, 2Department of Agricultural, Forestry and Food Sciences, University of Torino, Grugliasco, Torino, Italy

P 31 Molecular epidemiology, evolution and population dynamics of canine parvovirus (CPV) on a local and global scale C.M. Tucciarone1, G. Franzo1, E. Mazzetto1, M. Legnardi1, M. Caldin2, T. Furlanello3, M. Martini1, M. Cecchinato1, M. Drigo1

1Università degli Studi di Padova, Dipartimento di Medicina Animale Produzioni e Salute (MAPS), 2Clinica Veterinaria Privata “San Marco”, Veggiano Padova, 3Laboratorio Veterinario Privato “San Marco”, Veggiano Padova

P 32 First detection of Hunnivirus in a dog (Canis Lupus Familiaris) E. Muratore1, F. Grosjacques1, M. Messina1, A. Di Blasio1, S. Zoppi1, L. Costanzi2, B. Bassano2, A. Dondo1, M.G. Maniaci1, S. Colussi1, P.L. Acutis1, L. Masoero1, S. Peletto1

1Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d’Aosta, 2Parco Nazionale del Gran Paradiso

P 33 Detection and genetic characterization of Sapelovirus A in Italian swine herds E. Chelli1, L. De Sabato1, F. Ostanello2, G. Vaccari1, I. Di Bartolo1

1Department of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, Rome, Italy, 2Department of Veterinary Medical Sciences, University of Bologna, Ozzano dell’Emilia (BO), Italy

P 34 Circulation of Hepatitis E virus in wild boar population in Central Italy L. De Sabato1, F. Ostanello2, L. De Grossi3, A. Marcario3, B. Franzetti4, G. Ianiro1, A. Barone3, E. Martini5, M. Monini1, I. Di Bartolo1

1Department of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, Rome, Italy, 2Department of Veterinary Medical Sciences, University of Bologna, Ozzano dell’Emilia, Italy, 3Istituto Zooprofilattico sperimentale Lazio e Toscana, “M. Aleandri’’,Viterbo, Italy, 4Italian National Institute for Environmental Protection and Research, Ozzano dell’Emilia, Italy, 5ASL Viterbo, Viterbo, Italy

P 35 Enteric viruses in mussels from production areas in Greece I. Chaligiannis1, T. Vicenza2, D. Karagiannis3, G. La Rosa4, T. Papadopoulos5, C. Santana2, M. Andreopoulou6, E. Suffredini2

1Department of Microbiology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece, 2National Health Institute, Department of Food Safety, Nutrition and Veterinary Public Health, Rome, Italy, 3Laboratory of Ichthyology, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece, 4National Health Institute, Department of Environment and Health, Rome, Italy, 5Department of Microbiology and Infectious Diseases, School of Veterinary Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece, 6Faculty of Veterinary Medicine, University Leipzig, Leipzig, Germany

P 36 Optimization of digital PCR for the quantification of HAV virus in food analysis B. Bertasi1, E. Suffredini2, S. Lovari3, B. Boniotti1, S. Di Pasquale2, R. Benevenia1, F. Meletti1, D. De Medici2, M.N. Losio1

1Istituto Zooprofilattico Sperimentale della Lombardia ed Emilia Romagna, Brescia, 2Istituto Superiore di Sanità, Dipartimento di Sicurezza Alimentare, Nutrizione e Sanità Pubblica Veterinaria, Roma, 3Istituto Zooprofilattico Sperimentale del Lazio e Toscana

P 37 Bovine Herpetic Mammillitis in a dairy farm in Italy G. Lanave, V. Larocca, M. Losurdo, C. Catella, P. Capozza, M. Tempesta, V. Martella, C. Buonavoglia, M. Camero Department of Veterinary Medicine, University of Aldo Moro of Bari, Valenzano, Italy

P 38 Hepatitis E associated to consumption of wild boar sausages: a case report K. Marinelli1, S. Menzo1, S. Fisichella2, A. Duranti3, P. Bagnarelli1, G. Blasi3, C. Belardinelli4, T. Vicenza5, E. Suffredini5

1Ospedali Riuniti di Ancona, SOD Virologia, 2Istituto Zooprofilattico Sperimentale dell’Umbria e della Marche, Sezione di Tolentino, 3Istituto Zooprofilattico Sperimentale dell’Umbria e della Marche, Sezione di Fermo, 4ASUR Marche, Servizio Veterinario Area Vasta 3 Macerata, 5Istituto Superiore di Sanità, Dipartimento Sicurezza degli Alimenti, Nutrizione e Sanità pubblica Veterinaria

P 39 EMA-RT(q)PCR for the detection of viable Hepatitis E virus in food matrices T. Vicenza1, L. Cozzi1, S. Di Pasquale1, R. Johne3, I. De Magistris1, R. Lena2, A. Di Sandro2, E. Suffredini1, D. De Medici1

1Istituto Superiore di Sanità, Department of Food Safety, Nutrition and Veterinary Public Health, Rome, Italy, 2Ministero della Salute, Directorate General for Food hygiene and safety and Nutrition, Rome, Italy, 3German Federal Institute for Risk Assessment, Department Biological Safety, Berlin, Germany

POSTER

18

P 40 Virological survey of Hepatitis E virus in young swine population at the slaughterhouse: A molecular approach targeted to four biological matrices F. Grosjacques1, E. Muratore1, M. Messina1, C. Candela3, A.M. Vecchio3, C. Beltramo2, M. Botta3, S. Peletto2, L. Masoero1

1Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d’Aosta S.S. Virologia Torino (Italy), 2Istituto Zooprofilattico Sperimentale del Piemonte, della Liguria e della Valle D’Aosta, S.S. Genetica ed Immunobiochimica, 3Azienda Sanitaria Locale CN1- AREA B, Cuneo (Italy)

P 41 Inter- and intra-farm genetic diversity of swine influenza viruses in northeastern Italy A. Fusaro, A. Milani, L. Cavicchio, A. Pastori, A. Schivo, G. Zamperin, I. Monne, M. Mion, M.S. Beato Istituto Zooprofilattico Sperimentale delle Venezie, Padova, Italy

P 42 Spatiotemporal dynamics of Usutu viruses in northeastern Italy A. Fusaro1, A. Milani1, S. Ravagnan1, G. Da Rold1, C. Mavian2, A. Schivo1, G. Zamperin1, F. Toniolo1, A. Michelutti1, F. Montarsi1, G. Capelli1, I. Monne1

1IZSVe, Legnaro, Padova, Italy, 2Emerging Pathogens Institute and Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, USA

P 43 Retrospective analysis and follow-up of a cat positive to Hepadnavirus P. Capozza, G. Lanave, E. Delle Donne, G. Diakoudi, C. Catella, C. Buonavoglia, M. Camero, V. Martella Department of Veterinary Medicine, University of Bari, Valenzano, Italy

P 44 Assessment of Hepatitis E virus prevalence and quantitative levels in different food categories in Italy D. De Medici1, A. Guercio2, M.N. Losio3, P. De Santis4, G. Purpari2, E. Pavoni3, T. Vicenza1, L. Cozzi1, B.M. Varcasia4, S. Di Pasquale1, S. D’Amato5, E. Suffredini1, P. Schembri6

1Istituto Superiore di Sanità, Department of Food Safety, Nutrition and Veterinary Public Health - Rome, Italy, 2Istituto Zooprofilattico Sperimentale della Sicilia - Palermo, Italy, 3Istituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia Romagna - Brescia, Italy, 4Istituto Zooprofilattico Sperimentale del Lazio e della Toscana - Rome, Italy, 5Ministero della Salute, Directorate General for Health Prevention - Rome, Italy, 6Regione Sicilia, Health Directorate - Palermo, Italy

P 45 Cross reactivity antibody response after vaccination with modified live and killed bovine viral diarrhea virus (BVDV) vaccines C. Righi1, E. Sozzi2, M. Bazzucchi1, D. Lelli2, S. Petrini1, M. Boldini2, M. Gradassi2, L. Ferroni1, A. Lavazza2, G.M. De Mia1

1Istituto Zooprofilattico Sperimentale dell’Umbria e delle Marche “Togo Rosati”, 2Istituto Zooprofilattico Sperimentale della Lombardia e dell’Emila Romagna “Bruno Ubertini”

P 46 Genetic characterization of VP1/VP2 gene of recently identified Minute Virus of Canine in North-East Italy M. Campalto1, M. Carrino1, L. Tassoni1, G. Rizzo1, M. Cocchi2, P. De Benedicitis3, A. Natale1, L. Selli1, M.S. Beato1

1Diagnostic Virology Laboratory, 2Diagnostic Clinical Laboratory, 3Laboratory for zoonosis, emerging and re-emerging pathogens, Istituto Zooprofilattico Sperimentaledelle Venezie (IZSVe), Legnaro (Padova)

VIRAL DIAGNOSIS P 47 A new ELISA test for anti-HPV16 E7 circulating antibodies S. Falcucci1, F. Mastrogiovanni1, F. Paolini1, A.M. Mileo2, S. Massa3, A. Rinaldi4, R. Franconi5, A. Venuti1

1HPV-UNIT, Ridait Department, Regina Elena National Cancer Institute, Rome, Italy, 2Tumor Immunology and Immunotherapy UNIT, Ridait Department, IRCCS Regina Elena National Cancer Institute, Rome, Italy, 3Laboratory of Biotechnology (SSPT-BIO AG-BIOTEC), Department for Sustainability, Division Biotechnology and Agroindustry, Italian National Agency for New Technologies, Energy and the Environment (ENEA), ‘Casaccia’ Research Centre, Rome, Italy, 4NANOFABER srl, Rome, Italy, 5Laboratory of Biomedical Technologies (SSPT-TECS-TEB), Department for Sustainability, Division of Health Protection Technologies, Italian National Agency for New Technologies, Energy and the Environment (ENEA), ‘Casaccia’ Research Centre, Rome, Italy

P 48 A novel multiplex molecular approach to diagnose Dengue, Chikungunya and Malaria simultaneously S. Sinha1, R. Gahtori1, P. Kumari1, R.K. Baharia2, M. Saxena1, V. Pande3, A.R. Anvikar1, D. Savargaonkar1

1Indian Council of Medical Research - National Institute of Malaria Research, New Delhi, India, 2Indian Council of Medical Research - National Institute of Malaria Research, Nadiad, Gujarat India, 3Kumaun University, Uttarakhand, India

POSTER

19

VIRAL GENETICS AND BIOTECHNOLOGY P 49 Detection of circulating HERV-K(HML-2), a human endogenous retrovirus, involved in cancer and amyotrophic lateral sclerosis G. Ibba, C. Piu, C. Serra, A. Dolei Department of Biomedical Sciences, University of Sassari, Sassari, Italy

P 50 Early reduction of the splicing factor2/alternative splicing factor, cellular inhibitor of the JC polyomavirus in natalizumab-treated MS patients long before developing progressive multifocal leukoencephalopathy C. Serra1, C. Piu1, G. Ibba1, D. Bertoli2,3, R. Capra4, E. Uleri1, L. Imberti2, A. Dolei1

1Department of Biomedical Sciences, University of Sassari, Sassari, Italy, 2Centro di Ricerca Emato-oncologica AIL (CREA), Diagnostic Department, ASST Spedali Civili di Brescia, Italy, 3Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy, 4Multiple Sclerosis Centre, ASST Spedali Civili, Montichiari, BS, Italy

VIRAL ONCOLOGY P 51 Identification of small-molecule inhibitors of human papillomavirus E6-p53 interaction exerting anti-cancer activity M. Celegato1, L. Messa1, B. Mercorelli1, L. Goracci2, C. Bertagnin1, L. Banks3, G. Cruciani2, G. Palù1, A. Loregian1

1Department of Molecular Medicine, University of Padova, Padova, Italy, 2Department of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, Italy, 3International Centre for Genetic Engineering and Biotechnology, Trieste, Italy

P 52 Inhibition of NF-kB activation potentiates regulated cell death induced by azidothymidine in HTLV-1 infected cells F. Marino-Merlo1, C. Matteucci2, E. Balestrieri2, A. Minutolo2, E. Valletta2, S. Grelli2, B. Macchi3, A. Mastino4,5

1IRCCS Centro Neurolesi Bonino-Pulejo, Messina, Italy, 2Department of Experimental Medicine, University of Rome “Tor Vergata”, Rome, Italy, 3Department of Chemical Science and Technologies, University of Rome “Tor Vergata”, Rome, Italy, 4Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Messina, Italy, 5The Institute of Translational Pharmacology, CNR, Rome, Italy

P 53 HTLV-1: the neglected and yet most oncogenic human pathogen R.S. Accolla Laboratory of Immunology and General Pathology “Giovanna Tosi”, Department of Medicine and Surgery, School of Medicine, University of Insubria

P 54 Differential presence and expression of the splicing factor-2/alternative splicing factor (SF2/ASF) proto-oncogene in normal colon-rectal mucosa and biopsied samples from adenoma and adenocarcinoma lesions C. Piu1, E. Uleri1, M. Caocci1, G. Ibba1, F. Sanges2, G. Pira2, L. Murgia2, M. Barmina2, A. Porcu2, A.M. Scanu2, M. R. De Miglio2, C. Serra1, A. Dolei1

1Department of Biomedical Sciences, University of Sassari, Sassari, Italy, 2Department of Experimental Surgery and Medical Sciences, University of Sassari, Sassari

P 55 ECPV2 as a putative cause of equine gastric squamous cell carcinoma I. Porcellato1, P. Modesto2, K. Cappelli1, C. Brachelente1, I. Martini2, R. Gialletti1, L. Mechelli1, A. Ferrari2, A. Ghelardi3, E. Razzuoli2

1Dipartimento di Medicina Veterinaria, Perugia, 2Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle D’Aosta, National Reference Center of Veterinary and Comparative Oncology (CEROVEC), Genova, Italy, 3Azienda Usl Toscana Nord- Ovest, UOC Ostetricia e Ginecologia, Ospedale Apuane, Massa, Italy

POSTER

20

VIRUS-HOST INTERACTIONS P 56 HHV-6A infection of microglial cells induces the expression of Alzheimer’s disease risk factors D. Bortolotti, V. Gentili, E. Caselli, A. Rotola, D. Di Luca, R. Rizzo University of Ferrara, Department of Medical Sciences, Section of Microbiology and Medical Genetics, Ferrara, Italy

P 57 The US21 protein of Human Cytomegalovirus is a viroporin involved in the regulation of intracellular calcium homeostasis, apoptosis and cell migration A. Luganini, G. Di Nardo, L. Munaron, G. Gilardi, A. Fiorio Pla, G. Gribaudo Department of Life Sciences and Systems Biology, University of Torino, Torino, Italy

P 58 HIV-1 NefSF2 protein increases vesicles production in THP-1 human monocytic cells differentiated with PMA F. Giannessi1, A. Aiello1, Z.A Percario1, K. Fecchi2, M. Carollo3, M. Sargiacomo2, E. Affabris1

1Dept.of Science, University Roma Tre, Rome, Italy, 2Global Health Center, Istituto Superiore di Sanità, Rome, Italy, 3Core Facilities Cytometry Unit, Istituto Superiore di Sanità, Rome, Italy

P 59 HHV-6 infection and systemic sclerosis: clues of a possible association M. D’Accolti1, I. Soffritti1, D. Giuggioli2, C. Ferri2, E. Caselli1

1Section of Microbiology and Medical Genetics, Department of Medical Sciences, University of Ferrara, Ferrara, Italy, 2Rheumatology Unit, Medical School, University of Modena and Reggio Emilia, University-Hospital Policlinico of Modena, Modena, Italy

P 60 The retrocyclin analogue RC-101 inhibits Ebola virus infection in vitro M. Mirandola1, A. Calistri1, W. Lu2, C. Parolin1, G. Palù1, A. Garzino-Demo1,2, C. Salata1

1Department of Molecular Medicine, University of Padua, School of Medicine, Padua, Italy, 2Department of Biochemistry and Molecular Biology, University of Maryland, School of Medicine, Baltimore, Maryland, USA

P 61 HSV1 and Apoptosis: how virus fights against programmed cell death M. Buratto, M. Sicurella, F. Nicoli, F. Salvatori, S. Chendi, M. Pappadà, A. Caputo, P. Marconi Department of Chemical and Pharmaceutical Sciences, University of Ferrara

P 62 Circulating Extracellular Vesicles as new inflammation marker in HIV infection K. Falasca1, P. Lanuti2, C. Ucciferri1, D. Pieragostino3,4, M.C. Cufaro3,4, M.C. Bologna2,3, P. Del Boccio3,5, S. Miscia2,3, A. Occhionero1, M. Pontolillo1, A. Auricchio1, M. Marchisio2, J. Vecchiet1

1Clinic of Infectious Diseases, “G. d’Annunzio” University Chieti-Pescara - Italy, 2Department of Medicine and Science of Aging. “G. d’Annunzio” University Chieti-Pescara- Italy, 3Center for Advanced Studies and Technology, “G. d’Annunzio” University Chieti-Pescara - Italy, 4Dipartimento di Scienze Mediche, Orali e Biotecnologiche, “G. d’Annunzio” University Chieti-Pescara - Italy, 5Dipartimento di Farmacia, “G. d’Annunzio” University Chieti-Pescara - Italy

P 63 Role of viral immediate early (IE) genes in maintenance of cellular homeostasis in HSV1-infected cells M. Sicurella, F. Nicoli, M. Buratto, F. Salvatori, S. Chendi, M. Pappadà, R. Manservigi, A. Caputo, P. Marconi Department of Chemical and Pharmaceutical Sciences, University of Ferrara

P 64 A global analysis of viral classical nuclear localization signals E. Lavezzo, G. Palù, G. Alvisi Department of Molecular Medicine, University of Padua

POSTER

21

CONGRESS MAP

Entrance

Entrance

Aul

a M

agna

Aula Studio(lunch) DIASORIN

ABBOTT MOLECULAR

ARROW DIAGNOSTICS

HOLOGIC

Coffee break

Posters

43

2

1

1

2

3

4

EXHIBITION AREA:

Organizing Segreteriat

22

Congress VenuesAula Magna, Polo “A. Vallisneri”, Università degli Studi di PadovaVia G. Colombo, 3 - 35121 Padua, IPalazzo BoVia VIII Febbraio, 3 - 35122 Padua, I

CME AccreditationThe 3rd National Congress of the Italian Society for Virology has been accredited to the Italian Ministry of Health for the following professionals (ID ECM n. 150–267689 - 15,4 CME Credits): Medical Doctor (all disciplines), Biologist, Biotechnologist, Medical laboratory technician, Veterinary, Pharmacist, Physicist and Chemist.To obtain credits, registered participants are required to:• Wear the identification badge during working sessions• Provide their signature and write entrance/exit times before and after attending working sessions• Complete assessment and satisfaction questionnairesCredits will be given only if a participant attends 90% of the teaching event and provides correct answers to at least 75% of the questions included in the final assessment questionnaire. Accreditation will be documented by the Provider in CME certificates that will be sent to participants.Speakers will be given 1 credit for each half-hour of consecutive teaching. Speakers and moderators can receive credits as students (see Participants).

National educational objectiveGuidelines – protocols – procedures

Educational techniquesMaster lessons, presentations about specific topics

SVC AssobiomedicaThe Congress has been evaluated positively by SVC Assobiomedica in accordance withthe standard evaluation system

Official languagesItalian and English (no simultaneous translation provided)

Provider and Organizing SecretariatEffetti srlVia G.B. Giorgini 16, 20151 Milan, IPhone +39 02 3343281 - Fax +39 02 [email protected]

GENERALINFORMATION

23

The 3rd ISV Congress Committee and the CME Provider wish to thank for the support given to the Congress, as

unrestricted educational grants, the following Companies:

GOLD SPONSOR

SILVER SPONSORS

BRONZE SPONSORS

Abbott a.d.a. Arrow Diagnostics ELITechGroup

OTHER SPONSORS

3rd


nationalcongress


PaduaSeptember


di Padova

Chairs:G. Palù,

M.C. Parolin


Provider and Organizing SecretariatEffetti srl

Via G.B. Giorgini 16, 20151 Milan, IPhone +39 02 3343281 - Fax +39 02 38002105

[email protected]

Documents

M.C. Parolin - Arrow Diagnostics€¦ · Antonella Castagna, Milan Rossana Cavallo, Turin Paola De Benedictis, Legnaro (PD) Antonina Dolei, Sassari Davide Gibellini, Verona Giorgio