29
Monthly Healthcare Review May 2016 Company Name Last Financing Date HQ Location Description Last Financing Size (Millions) Lead Manager Reata Pharmaceuticals (RETA) 25-May-16 Irving, TX Developer of oral anti-inflammatory drugs for intractable diseases, including antioxidant inflammation modulating drugs, as well as drugs that correct protein misfolding. 60.50 Undisclosed Merus (MRUS) 19-May-16 Utrecht, Netherlands The company develops human therapeutic antibody therapies for cancer by addressing multiple therapeutic targets with a single antibody product. 55.00 Undisclosed PhaseRx (PZRX) 18-May-16 Seattle, WA The company provides a technology platform based on multi-functional polymeric vehicles that enable the delivery of macromolecular therapeutic drugs. 18.50 Undisclosed Oncobiologics 12-May-16 Cranbury, NJ A biopharmaceutical firm that specializes in developing a pipeline of biosimilars and biotherapeutics for the treatment of cancer and immune system disorders. 35.00 Undisclosed Spring Bank Pharmaceuticals (SBPH) 6-May-16 Milford, MA Provider of a drug discovery platform. The company develops small molecule nucleic acid hybrids. 11.04 Individual Investor Intellia Therapeutics (NTLA) 6-May-16 Cambridge, MA Developer of potentially curative therapeutics utilizing a recently developed biological tool for therapeutic gene editing known as the CRISPR/Cas9 system. 108.00 Novartis Venture Funds, Regeneron Pharmaceuticals Unite De Fabrication De Medicaments 4-May-16 Sousse, Tunisia Contract manufacturer of pharmaceutical products for domestic hospitals, private markets, and large international pharmaceutical companies such as Pfizer, Mylan and Thea. It has drug registrations covering mainly liquid injectables, powder injectables and eye drops. 149.09 Blakeney Management, PROPARCO The following table includes the medical devices, biotechnology, pharmaceuticals, and healthcare IPO pricings, filings and withdrawals announced over the previous month. IPOs Compiled By: Terence Yen Sources: PitchBook, Wall Street Journal, SEC Filings, Company Press Releases, fiercebiotech.com, PE HUB, and biospace.com 1

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Page 1: May 2016 MiR - BioEnterprise · 2016-09-25 · Medicaid Services), as well as filtering tools, to help patients review providers of specialized care. 17.85 Pritzker Group Venture

Monthly Healthcare Review May 2016

Company NameLast Financing

DateHQ Location Description

Last Financing

Size (Millions)

Lead Manager

Reata Pharmaceuticals (RETA)

25-May-16 Irving, TX Developer of oral anti-inflammatory drugs for intractable diseases, including antioxidant inflammation modulating drugs, as well as drugs that correct protein misfolding.

60.50 Undisclosed

Merus (MRUS) 19-May-16 Utrecht, Netherlands

The company develops human therapeutic antibody therapies for cancer by addressing multiple therapeutic targets with a single antibody product.

55.00 Undisclosed

PhaseRx (PZRX) 18-May-16 Seattle, WA The company provides a technology platform based on multi-functional polymeric vehicles that enable the delivery of macromolecular therapeutic drugs.

18.50 Undisclosed

Oncobiologics 12-May-16 Cranbury, NJ A biopharmaceutical firm that specializes in developing a pipeline of biosimilars and biotherapeutics for the treatment of cancer and immune system disorders.

35.00 Undisclosed

Spring Bank Pharmaceuticals (SBPH)

6-May-16 Milford, MA Provider of a drug discovery platform. The company develops small molecule nucleic acid hybrids.

11.04 Individual Investor

Intellia Therapeutics (NTLA)

6-May-16 Cambridge, MA Developer of potentially curative therapeutics utilizing a recently developed biological tool for therapeutic gene editing known as the CRISPR/Cas9 system.

108.00 Novartis Venture Funds, Regeneron Pharmaceuticals

Unite De Fabrication De Medicaments

4-May-16 Sousse, Tunisia Contract manufacturer of pharmaceutical products for domestic hospitals, private markets, and large international pharmaceutical companies such as Pfizer, Mylan and Thea. It has drug registrations covering mainly liquid injectables, powder injectables and eye drops.

149.09 Blakeney Management, PROPARCO

The following table includes the medical devices, biotechnology, pharmaceuticals, and healthcare IPO pricings, filings and withdrawals announced over the previous month.

IPOs

Compiled By: Terence YenSources: PitchBook, Wall Street Journal, SEC Filings, Company Press Releases, fiercebiotech.com, PE HUB, and biospace.com 1

Page 2: May 2016 MiR - BioEnterprise · 2016-09-25 · Medicaid Services), as well as filtering tools, to help patients review providers of specialized care. 17.85 Pritzker Group Venture

Monthly Healthcare Review May 2016

Company NameLast

Financing Date

HQ Location Round Description

Last Financing

Size (Millions)

Lead Investor(s)

Whill 31-May-16 San Francisco, CA Early Stage VC Developer of a motorized wheelchair that can be driven on sidewalks and is steered by leaning the handle in the direction the user wishes to go.

17.50 Undisclosed

Spine Wave 31-May-16 Shelton, CT Later Stage VC The company provides surgical solutions for spinal fusion, vertebral compression fracture repair and nucleus replacement and augmentation.

11.00 Acadia Woods Partners, New Enterprise Associates

Kineta 31-May-16 Seattle, WA Later Stage VC The company develops antiviral therapies and immune modulating drugs for RNA viruses, a molecular on/off switch that triggers the human body's immune defenses against virus infection.

0.07 Undisclosed

Vicarious Surgical 27-May-16 Cambridge, MA Early Stage VC Developer of a software for use in surgical procedures. The company develops a virtual reality software integrated with surgical robotics for use in minimally invasive surgical procedures.

1.00 Chandler Wang, River, Rothenberg Ventures

Podimetrics 27-May-16 Somerville, MA Early Stage VC Developer of mats for prevention of diabetic foot ulcers. The company's patent-pending technology aims to detect these ulcers before they develop, allowing for timely, inexpensive treatment.

5.82 Andrew Palmer, Koa Labs, Norwich Ventures, Rock Health

PanOptica 27-May-16 Bernardsville, NJ Early Stage VC Provider of therapies for the treatment of age-related muscular degeneration and diabetic retinopathy.

45.00 Novo, SV Life Sciences Advisers, Third Rock Ventures

NX Development 27-May-16 Louisville, KY Angel The company designs and develops Gliolan, a glioblastoma imaging agent, used in fluorescent guided neurosurgery, cancer surgery, radiotherapy and chemotherapy operations.

0.70 Fred Mermelstein, Robert Saunders, Ulrich Kosciessa

Ixaltis 27-May-16 Toulouse, France Early Stage VC Developer of therapeutics to treat genitourinary diseases. 9.07 Undisclosed

Braeburn Pharmaceuticals

27-May-16 Princeton, NJ Early Stage VC Developer of implantable and injectable therapies for serious neurological and psychiatric disorders,

23.00 Apple Tree Partners

Private Equity Placements and Venture Capital RoundsThe following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

Compiled By: Terence YenSources: PitchBook, Wall Street Journal, SEC Filings, Company Press Releases, fiercebiotech.com, PE HUB, and biospace.com 2

Page 3: May 2016 MiR - BioEnterprise · 2016-09-25 · Medicaid Services), as well as filtering tools, to help patients review providers of specialized care. 17.85 Pritzker Group Venture

Monthly Healthcare Review May 2016

Company NameLast

Financing Date

HQ Location Round Description

Last Financing

Size (Millions)

Lead Investor(s)

Private Equity Placements and Venture Capital RoundsThe following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

Aleva Neurotherapeutics

27-May-16 Lausanne, Switzerland

Later Stage VC Developer of medical devices for the treatment of neurological diseases. The company develops implants for Deep Brain Stimulation (DBS) therapy.

18.00 Greatbatch

SilverVue 26-May-16 Sandy, UT Early Stage VC The company provides a searchable tablet application used by hospital case managers to help patients choose their post-acute care (PAC) provider. The application includes ratings by the CMS (Centers for Medicare & Medicaid Services), as well as filtering tools, to help patients review providers of specialized care.

17.85 Pritzker Group Venture Capital

Wellth 25-May-16 Brooklyn, NY Early Stage VC The company offers a patient-facing mobile application that encourages medication and treatment adherence by paying patients to be healthy.

2.00 AXA Strategic Ventures

Arrivo BioVentures 25-May-16 Morrisville, NC Early Stage VC The company develops biopharmaceutical products that focuse on accelerating biologics and small molecules through clinical development that have the potential to improve patient lives and expedite the path to approval and the efficient implementation of the clinical programs themselves.

49.00 Jazz Pharmaceuticals, Rex Health Ventures, Solas Bioventures

Appili Therapeutics 25-May-16 Halifax, Canada Seed Round The company provides antiviral, anti-fungal, anti-parasitic and anti-microbial based agents for the treatment of infectious disease.

3.27 Atlantic Canada Opportunities Agency, Bloom Burton & Co., Innovacorp, National Research Council Canada

Zebra Medical Vision 24-May-16 Kibbutz Shefayim, Israel

Early Stage VC The company provides a platform that offers a cloud-based research and development environment including access to data sets of structured, de-identified studies, storage, GPU computing power and support for research tools.

12.00 Intermountain Healthcare

VuEssence 24-May-16 Odessa, FL Angel Provider of surgical and medical instruments. 1.20 UndisclosedVerena Solutions 24-May-16 Chicago, IL Angel Developer of products that enhance the safety of dental and medical

procedures.0.20 Christ Harvey, Jim

Mathes, John Tanner

Compiled By: Terence YenSources: PitchBook, Wall Street Journal, SEC Filings, Company Press Releases, fiercebiotech.com, PE HUB, and biospace.com 3

Page 4: May 2016 MiR - BioEnterprise · 2016-09-25 · Medicaid Services), as well as filtering tools, to help patients review providers of specialized care. 17.85 Pritzker Group Venture

Monthly Healthcare Review May 2016

Company NameLast

Financing Date

HQ Location Round Description

Last Financing

Size (Millions)

Lead Investor(s)

Private Equity Placements and Venture Capital RoundsThe following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

TransMedics 24-May-16 Andover, MA Later Stage VC The company develops a portable warm blood perfusion system that allows for a new type of organ transplant called a living organ transplant, which maintains organs in a warm, functioning state outside of the body during transfer from organ donor to recipient.

51.23 Fayerweather Fund, Inbio Ventures

Strong Arm Technologies

24-May-16 Brooklyn, NY Early Stage VC Manufacturer of a load-distribution device that helps in reducing load-caused injuries.

2.92 Undisclosed

OncoResponse 24-May-16 Houston, TX Early Stage VC Developer of therapeutic antibodies against immuno-oncology targets. 19.50 ARCH Venture Partners, Baxalta Ventures

Neuraltus Pharmaceuticals

24-May-16 Palo Alto, CA Later Stage VC Developer of therapeutics for the treatment of neurodegenerative diseases such as amyotrophic lateral sclerosis, Parkinson's disease, Alzheimer's disease and multiple sclerosis.

14.94 Adams Street Partners, Latterell Venture Partners, VantagePoint Capital Partners

Molekule 24-May-16 San Francisco, CA Seed Round Developer of an indoor air purifier based on molecular technology which takes bacteria, allergens, mold, chemicals and viruses; breaks them down into elements that aren't harmful; then releases these elements back into the air.

3.25 SoftTech VC

Daktari Diagnostics 24-May-16 Cambridge, MA Later Stage VC The company offers technology to detect HCV and HIV, helps in data management, as well as helps to test and identify infants with sickle cell disease.

22.50 Undisclosed

Clarity Pharmaceuticals 24-May-16 Sydney, Australia Angel The company focuses on developing radio-pharmaceuticals for the treatment of serious diseases.

1.53 Undisclosed

CardioNXT 24-May-16 Westminster, CO Early Stage VC The company offers a range of devices to treat cardiac conditions, such as atrial fibrillation detection, and to deliver targeted therapy to affected areas within the heart.

1.55 Office of Economic Development and International Trade, Solas Bioventures

Compiled By: Terence YenSources: PitchBook, Wall Street Journal, SEC Filings, Company Press Releases, fiercebiotech.com, PE HUB, and biospace.com 4

Page 5: May 2016 MiR - BioEnterprise · 2016-09-25 · Medicaid Services), as well as filtering tools, to help patients review providers of specialized care. 17.85 Pritzker Group Venture

Monthly Healthcare Review May 2016

Company NameLast

Financing Date

HQ Location Round Description

Last Financing

Size (Millions)

Lead Investor(s)

Private Equity Placements and Venture Capital RoundsThe following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

BrightWater Medical 24-May-16 Mountain View, CA Angel Developer of medical devices for patients suffering from biliary and urinary blockages. The company offers a convertible stent that gets converted from catheter to a nephroureteral stent without a second interventional procedure and helps in treatment.

5.20 Central Illinois Angels

Apixio 24-May-16 San Mateo, CA Later Stage VC The company offers a platform designed to access medical records for optimal healthcare decision making.

19.30 SSM Partners

Nucleix 23-May-16 Rehovot, Israel Later Stage VC The company has developed Bladder EpiCheck, a bladder cancer test, that includes a panel of 15 DNA methylation biomarkers for detection of bladder cancer.

3.00 Aurum Ventures MKI, European Commission, OrbiMed Advisors, Zohar Zisapel

Medasense Biometrics 23-May-16 Ramat Gan, Israel Later Stage VC The company provides a pain monitoring device to measure the physiological response to pain, providing new insights into pain management care.

8.00 Benslie International

Eagledream Health 23-May-16 Rochester, NY Angel The company develops software that enables physicians and healthcare teams to deliver quality care to patients, create opportunities for patient engagement and increase efficiency and lower costs.

1.76 Cranberry Capital

DefiniGEN 23-May-16 Cambridge, United Kingdom

Early Stage VC The company has developed a stem cell production platform, OptiDIFF, for the generation of high-functionality cell types including liver, pancreatic and lung cells.

2.14 Undisclosed

Tensive 20-May-16 Milano, Italy Early Stage VC The company provides porous implantable prostheses based on biodegradable synthetic biomaterials and fabricated with internal mirco-channels mimicking the blood-vessels architecture for the treatment of breast cancer.

2.15 Invitalia Ventures, Marzotto Family, Seedlab, UniCredit

Compiled By: Terence YenSources: PitchBook, Wall Street Journal, SEC Filings, Company Press Releases, fiercebiotech.com, PE HUB, and biospace.com 5

Page 6: May 2016 MiR - BioEnterprise · 2016-09-25 · Medicaid Services), as well as filtering tools, to help patients review providers of specialized care. 17.85 Pritzker Group Venture

Monthly Healthcare Review May 2016

Company NameLast

Financing Date

HQ Location Round Description

Last Financing

Size (Millions)

Lead Investor(s)

Private Equity Placements and Venture Capital RoundsThe following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

P&C Pharma 20-May-16 Centerville, OH Early Stage VC The company provides services to improve the dosing of medications, increase compliance and enhance therapy by the use of personalized pharmaceutical products.

2.21 Dayton Development Coalition, Ohio's Hospice of Dayton, Rev1 Ventures

MediQuire 20-May-16 New York, NY Early Stage VC The company offers a software which enables customers to identify clinical, operational and financial improvement opportunities and delivers actionable alerts to clinicians in their daily workflow.

4.88 FCA Venture Partners

Ichor Vascular 20-May-16 North Webster, IN Angel Developer of a percutaneous arterial embolectomy system that helps to treat critical limb ischemia.

0.20 Undisclosed

HeartFlow 20-May-16 Redwood City, CA Later Stage VC The company focuses on providing healthcare professionals with actionable knowledge about individual patients. The company's technology is designed for diagnosis of coronary artery disease and data.

99.93 Undisclosed

Geneticure 20-May-16 Minnetonka, MN Angel The company develops genetic tests that help doctors and clinicians create personalized and patient-specific treatments for controlling high blood pressure and hypertension.

0.67 Undisclosed

Epic Extremity 20-May-16 Cranberry Township, PA

Angel The company specializes in designing and developing orthopedic implants through an innovative business model that allows cost effective alternatives to the typical big branded companies.

0.40 Undisclosed

Empire Genomics 20-May-16 Buffalo, NY Later Stage VC Operator of a molecular diagnostics company. The company offers art testing products and assay services for cancer disease management, autism, schizophrenia and mental retardation.

1.75 BroadOak Capital Partners

Avizia 20-May-16 Reston, VA Early Stage VC The company has developed a platform that allows medical experts to reach out to their patients through telemedicine.

3.11 Undisclosed

Alpha Logic 20-May-16 Pasadena, CA Angel Developer of a diagnostic device to record discrete abdominal sounds and vibrations to monitor and diagnose digestive disorders.

3.31 Undisclosed

Tamir Biotechnology 19-May-16 San Diego, CA Early Stage VC Developer of therapeutic drugs. The company engages in the development of drugs that are used for the treatment of cancer and other pathological conditions.

1.52 Undisclosed

Compiled By: Terence YenSources: PitchBook, Wall Street Journal, SEC Filings, Company Press Releases, fiercebiotech.com, PE HUB, and biospace.com 6

Page 7: May 2016 MiR - BioEnterprise · 2016-09-25 · Medicaid Services), as well as filtering tools, to help patients review providers of specialized care. 17.85 Pritzker Group Venture

Monthly Healthcare Review May 2016

Company NameLast

Financing Date

HQ Location Round Description

Last Financing

Size (Millions)

Lead Investor(s)

Private Equity Placements and Venture Capital RoundsThe following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

Sana 19-May-16 Burnham, United Kingdom

Accelerator / Incubator

The company develops sleeping masks designed with the help of medical applications including stroke rehabilitation, treatment of traumatic brain injury, insomnia, epilepsy, stress disorder and pain control.

0.06 SOSV

Piper Therapeutics 19-May-16 Cambridge, MA Angel Provider of pre-clinical drug discovery services and developer of therapies that affect inflammatory signaling and immune system response.

1.30 Undisclosed

Calibrater Health 19-May-16 Hanover, NH Accelerator / Incubator

The company offers real-time mobile patient feedback with tracking and reporting tools that categorizes and routes patient comments for follow-up and immediate action.

0.15 FirstGrowth Venture Network, Jumpstart Foundry

Arcadian TelePsychiatry 19-May-16 Philadelphia, PA Seed Round Operator of an online tele-psychiatry platform. It serves the patients needing help with depression, anxiety, panic attacks, PTSD and marriage problems without having them to commute.

Undisclosed Ben Franklin Technology Partners of Southeastern Pennsylvania

Virtual Health 18-May-16 New York, NY Early Stage VC The company offers a managed care platform that enables patient engagement, population management, care coordination, readmissions minimization, data analytics, social networking and multi-dimensional communication.

2.55 Edison Partners

VantagePoint Laboratory

18-May-16 San Diego, CA PE Growth / Expansion

The company provides esoteric testing services such as molecular testing, solid tumor testing, technical and professional component testing, cytogenic, FISH testing and hematopathology testing services.

6.78 Enhanced Equity Funds

SpeechVive 18-May-16 Lafayette, IN Seed Round The company has developed a device that will improve the speech of patients suffering from Parkinson’s disease without placing cognitive demand on the patient.

2.28 Undisclosed

Medical 21 18-May-16 Minneapolis, MN Angel Developer of an artificial graft. The company develops grafts for use in coronary bypass heart surgeries.

0.20 Undisclosed

Compiled By: Terence YenSources: PitchBook, Wall Street Journal, SEC Filings, Company Press Releases, fiercebiotech.com, PE HUB, and biospace.com 7

Page 8: May 2016 MiR - BioEnterprise · 2016-09-25 · Medicaid Services), as well as filtering tools, to help patients review providers of specialized care. 17.85 Pritzker Group Venture

Monthly Healthcare Review May 2016

Company NameLast

Financing Date

HQ Location Round Description

Last Financing

Size (Millions)

Lead Investor(s)

Private Equity Placements and Venture Capital RoundsThe following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

CRG Medical 18-May-16 Houston, TX Angel The company provides an analytical system for measuring and reducing vulnerability to patient safety threats. The company also develops an application which allows early detection of hazards.

1.00 Houston Technology Center

CarePredict 18-May-16 Plantation, FL Early Stage VC The company designs and manufactures a wrist-worn sensor with an embedded software that tracks normal daily activities of senior citizens to detect their health conditions.

1.31 Undisclosed

BioMarcK Pharmaceuticals

18-May-16 Durham, NC Later Stage VC The company engages in the discovery and development of drugs for the treatment of pulmonary diseases and disorders associated with the over-secretion of mucus and pulmonary inflammation.

7.00 Cato BioVentures, Individual Investor, National Institutes of Health, U.S. Department of Health and Human Services

SCILEX Pharmaceuticals

17-May-16 Malvern, PA Angel Developer of pharmaceutical products for pain treatment. The company focuses on developing adhesive and pliable properties designed to permit skin contact throughout the dosing regimen and thereby reduce pain.

0.48 ITOCHU

Purigen Biosystems 17-May-16 Pleasanton, CA Early Stage VC Developer of an isotachophoresis chip for nucleic acid preparation to be used for genomic analyses.

18.20 5AM Ventures, Roche Venture Fund

PatientPop 17-May-16 Santa Monica, CA Early Stage VC Developer of an online marketing platform for medical professionals. The company provides services for patient acquisition, reputation management, retention marketing and business insights.

10.50 Toba Capital

Nouscom 17-May-16 Basel, Switzerland Early Stage VC The company has developed a next generation of oncolytic viruses that infect and kill tumor cells to stimulate an immune response against cancer cells throughout the body.

13.60 Life Sciences Partners, Versant Ventures

Noble.MD 17-May-16 Bryn Mawr, PA Early Stage VC The company develops a web-based platform to proactively identify patient health risks and activate patients to manage those risks through proven programs and interventions.

1.45 BioAdvance, Safeguard Scientifics

Compiled By: Terence YenSources: PitchBook, Wall Street Journal, SEC Filings, Company Press Releases, fiercebiotech.com, PE HUB, and biospace.com 8

Page 9: May 2016 MiR - BioEnterprise · 2016-09-25 · Medicaid Services), as well as filtering tools, to help patients review providers of specialized care. 17.85 Pritzker Group Venture

Monthly Healthcare Review May 2016

Company NameLast

Financing Date

HQ Location Round Description

Last Financing

Size (Millions)

Lead Investor(s)

Private Equity Placements and Venture Capital RoundsThe following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

Keystone Mobile Partner

17-May-16 Willow Grove, PA Angel The company operates mobile units that provide a range of urological care services for patients. It also specializes in providing flexible choice of location for physicians and hospitals for performing the treatment.

0.06 Undisclosed

Innovative Cardiovascular Solutions

17-May-16 Grand Rapids, MI Angel The company develops an embolic protection catheter that has been designed to be utilized in trans-aortic valve replacement (TAVR) procedures and other left heart interventional procedures where embolic protection would be required.

1.41 Undisclosed

IDP Discovery Pharma 17-May-16 Barcelona, Spain Seed Round The company develops therapies for the treatment of leukemia, other blood cancers and hematologic malignancies.

1.59 ACCIÓ, CDTI (NEOTEC), ENISA, Ministerio de Economia y Competitividad

Healthify 17-May-16 New York, NY Seed Round Provider of a healthcare-referral platform for patients who need additional help from social services. The company serves health-plan operators, hospitals and provider networks working in low-income communities.

2.50 Undisclosed

FlexSpark 17-May-16 Atlanta, GA Angel Developer of a wearable electrical muscle stimulation therapeutic device that enables users to skip long rehabilitation process by preventing blood clots and muscle atrophy when the patient is immobile.

0.10 Zeroto510

Dharma 17-May-16 Washington, DC Seed Round The company provides mobile and web-based tools for individuals, companies, and organizations that help field healthcare workers and researchers to collect, understand and analyze the medical data gathered in field situations.

1.60 Concur Technologies (Venture Arm), SAP

Decisio Health 17-May-16 Houston, TX Early Stage VC The company focuses on availability of vital patient data, unprecedented automation and premier analytics. It also provides organizations an opportunity to identify and correct areas of operational deficiencies.

4.50 DECLATEX, Larry Lawson, UT Horizon Fund

Compiled By: Terence YenSources: PitchBook, Wall Street Journal, SEC Filings, Company Press Releases, fiercebiotech.com, PE HUB, and biospace.com 9

Page 10: May 2016 MiR - BioEnterprise · 2016-09-25 · Medicaid Services), as well as filtering tools, to help patients review providers of specialized care. 17.85 Pritzker Group Venture

Monthly Healthcare Review May 2016

Company NameLast

Financing Date

HQ Location Round Description

Last Financing

Size (Millions)

Lead Investor(s)

Private Equity Placements and Venture Capital RoundsThe following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

Combinostics 17-May-16 Tampere, Finland Seed Round Developer of diagnostic software. The company develops software tools for data-driven diagnostics using heterogeneous patient data.

0.76 Integral Capital Partners, Riku Asikainen

CardioFocus 17-May-16 Marlborough, MA Later Stage VC Developer of a medical device for ablation treatments for cardiac disorders. The company develops HeartLight Endoscopic Ablation System for the treatment of atrial fibrillation.

8.00 Undisclosed

B.I.S. 17-May-16 Ngaliema Kinshasa, Congo

PE Growth / Expansion

Producer of generic pharmaceutical products. The company produces and markets tested drugs to prevent and cure infections to ears, eyes and throat.

Undisclosed XSML

Axion Biosystems 17-May-16 Atlanta, GA Later Stage VC Provider of life science instrumentation, medical diagnostics and implantable stimulation devices. The company provides microelectrode arrays, related system electronics, electrode technology and artifact elimination.

6.27 Undisclosed

Ascendance Biotechnology

17-May-16 Medford, MA Angel Developer of stem-cell-derived assays and other products based on stem cell technologies.

0.23 Undisclosed

Allurion Technologies 17-May-16 Wellesley, MA Later Stage VC Developer of a medical device for obesity, designed to induce weight loss by displacing volume in the stomach without surgery, leveraging super-porous hydrogel technology.

6.00 Massachusetts Life Sciences Center, Romulus Capital

Agenovir 17-May-16 South San Francisco, CA

Early Stage VC Developer of novel therapeutics. The company specializes in developing a novel class of nuclease-based anti-viral therapeutics for diseases associated with viral reservoirs.

10.60 California Institute for Quantitative Biosciences, Celgene, Data Collective, JLabs, Lightspeed Venture Partners

Vavotar Life Sciences 16-May-16 Cumming, GA Angel Undisclosed 3.52 UndisclosedThe Pill Club 16-May-16 Redwood City, CA Accelerator /

IncubatorThe company designs a mobile application for delivering medicines at users' door steps and allows them to manage and refill their prescriptions. It also provides information about birth control and emergency contraception.

0.13 500 Startups, StartX

Compiled By: Terence YenSources: PitchBook, Wall Street Journal, SEC Filings, Company Press Releases, fiercebiotech.com, PE HUB, and biospace.com 10

Page 11: May 2016 MiR - BioEnterprise · 2016-09-25 · Medicaid Services), as well as filtering tools, to help patients review providers of specialized care. 17.85 Pritzker Group Venture

Monthly Healthcare Review May 2016

Company NameLast

Financing Date

HQ Location Round Description

Last Financing

Size (Millions)

Lead Investor(s)

Private Equity Placements and Venture Capital RoundsThe following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

Notable Labs 16-May-16 San Francisco, CA Early Stage VC Provider of therapy research services focused on brain cancer. The company provides a platform enabling doctors to seek and evaluate combinations of FDA-approved treatments for patients with brain cancer.

4.49 Undisclosed

Mitralign 16-May-16 Tewksbury, MA Later Stage VC Developer of a catheter-based mitral valve repair system. The company has developed a direct transcatheter annuloplasty system designed to treat both functional mitral regurgitation and tricuspid regurgitation.

31.75 Undisclosed

Inotec AMD 16-May-16 Cambridge, United Kingdom

Later Stage VC The company is the developer of a mobile, battery-powered device that is applied near a chronic wound and produces a continuous flow of humidified oxygen, optimizing the healing process.

Undisclosed Amadeus Capital Partners, Cambridge Angels, Cambridge Capital Group, Cambridge Enterprise, NHS England, Parkwalk Advisors

eXIthera Pharmaceuticals

16-May-16 Westborough, MA Early Stage VC The company develops a small-molecule, oral-delivery drug based on inhibiting the factor XI enzyme made by the liver which is involved in a critical stage of the coagulation process.

10.00 Clal Biotechnology Industries, Schooner Capital

Centauri Health Solutions

16-May-16 Scottsdale, AZ PE Growth / Expansion

Provider of data management and cloud based software services. The company is engaged in improving the financial performance for health plans and at-risk providers by supporting initiatives in risk adjustment.

50.00 Silversmith Capital Partners

Caribou Biosciences 16-May-16 Berkeley, CA Early Stage VC Developer of a technology for cell and genome engineering. The company offers technology-based services for cellular engineering and analysis based on the CRISPR-Cas9 technology platform.

30.00 Undisclosed

B-MoGen Biotechnologies

16-May-16 St. Paul, MN Seed Round Provider of genome editing services. The company designs and develops biological research tools required for genome engineering products and services in the biotechnology industry.

1.03 Bio-Techne

Compiled By: Terence YenSources: PitchBook, Wall Street Journal, SEC Filings, Company Press Releases, fiercebiotech.com, PE HUB, and biospace.com 11

Page 12: May 2016 MiR - BioEnterprise · 2016-09-25 · Medicaid Services), as well as filtering tools, to help patients review providers of specialized care. 17.85 Pritzker Group Venture

Monthly Healthcare Review May 2016

Company NameLast

Financing Date

HQ Location Round Description

Last Financing

Size (Millions)

Lead Investor(s)

Private Equity Placements and Venture Capital RoundsThe following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

BioSight 16-May-16 Karmiel, Israel Later Stage VC Developer of novel peptide-based drugs for the treatment of different types of cancers with reduced toxicity, based on proprietary technology S2DOT™ for chemotherapy pro-drug synthesis.

13.00 Arkin Holdings, Avi Yehezkel, Michael Ilan Management And Investments, Primera Capital, The Trendlines Group

B4CC 16-May-16 Gainesville, GA Angel Provider of a clinical network offering therapies to patients. The company's network harvests tumor tissue, analyzes it and conducts research trials to come up with therapies to be used for cancer patients.

0.92 Undisclosed

Advantagene 16-May-16 Auburndale, MA Angel The company focuses on preventing the recurrence and progression of cancer through the use of therapeutics in oncology and immunotherapy.

8.68 Massachusetts Life Sciences Center, U.S. Department of Health and Human Services

Upstream Health Systems

13-May-16 Seattle, WA Seed Round The company provides services for the identification, prediction and prevention of diseases in human populations, and it synthesizes data from public and private data streams.

1.53 J. Corey Schmid, Matt Abrams, Seven Peaks Ventures

Rochester Medical Management

13-May-16 Rochester, MN Angel Provider of clinical-grade technology commercializing services. The company commercializes diagnostic and monitoring medical technologies to help reduce cost of healthcare.

0.05 Undisclosed

Compiled By: Terence YenSources: PitchBook, Wall Street Journal, SEC Filings, Company Press Releases, fiercebiotech.com, PE HUB, and biospace.com 12

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Monthly Healthcare Review May 2016

Company NameLast

Financing Date

HQ Location Round Description

Last Financing

Size (Millions)

Lead Investor(s)

Private Equity Placements and Venture Capital RoundsThe following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

Photosonix Medical 13-May-16 Ambler, PA Seed Round Developer of a skin acne treatment device. The company offers an energy-based therapy device used to treat acne bacteria.

1.67 Ben Franklin Technology Partners of Southeastern Pennsylvania, National Institute of Health, Princeton Biopharma Capital Partners

OrthoSensor 13-May-16 Dania Beach, FL Later Stage VC Developer of orthopedic implants and sensor-assisted surgery systems, with external and implanted sensors that detect and monitor various functions in the musculoskeletal system.

0.21 Bridger Healthcare, Dignity Health, Highbridge Principal Strategies Growth Equity, Tullis Health Investors, Ziegler Healthcare Capital

Impulse Dynamics 13-May-16 Stuttgart, Germany Angel Manufacturer of implantable medical devices and developer of electrical therapies for treatment of chronic heart failure.

30.00 Hobart Group, Peter Lee Ka Kit

DalCor 13-May-16 Montreal, Canada Early Stage VC Developer and provider of precision cardiovascular medicine to patients through identification of patient populations.

100.00 Andre Desmarais, Caisse de dépôt et placement du Québec, CTI Life Sciences Fund, Fonds de solidarité FTQ, Sanderling Ventures

Compiled By: Terence YenSources: PitchBook, Wall Street Journal, SEC Filings, Company Press Releases, fiercebiotech.com, PE HUB, and biospace.com 13

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Monthly Healthcare Review May 2016

Company NameLast

Financing Date

HQ Location Round Description

Last Financing

Size (Millions)

Lead Investor(s)

Private Equity Placements and Venture Capital RoundsThe following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

Curaseal 13-May-16 Santa Clara, CA Later Stage VC The company engages in the development of products and technologies to further delivery and administration of therapeutics including collagen, antimicrobial chemotherapy, growth factors and cell based therapies.

3.50 Ascent Biomedical Ventures, Windham Venture Partners

BiOptix Diagnostics 13-May-16 Boulder, CO Later Stage VC Developer of a biomolecule detection system. The company provides the E-SPR (Enhanced Surface Plasmon Resonance) technology platform for the detection of molecular interactions.

2.46 Boulder Ventures, Peierls Foundation, Remeditex Ventures, Rusnano

MedCPU 12-May-16 New York, NY Later Stage VC The company's application captures and analyzes the clinical picture from clinicians' free-text notes, dictations and structured documentation against a growing library of content for generating real-time precise prompts for care consideration.

35.04 Easton Capital Investment Group, Merck Global Health Innovation, New Richmond Ventures, UPMC Health System

Medal 12-May-16 San Francisco, CA Angel Developer of a medical information sharing application. The company's application helps to catalog and share medical records with family and healthcare practitioners for the purpose of treatment.

3.78 Justin Rosenstein, Lee Linden

HCIactive 12-May-16 Glenwood, MD Later Stage VC The company develops a cloud-based integrative platform that offers detailed analytic, data transactions, plan administration and fast reporting.

3.41 Grotech Ventures, Harbert Growth Partners, Maryland Venture Fund

EndoStim 12-May-16 St. Louis, MO Later Stage VC Developer of microstimulator technology to treat sphincter-related disorders. The company develops therapies to treat gastrointestinal and urological neuromuscular disorders.

25.00 Endeavour Vision

Compiled By: Terence YenSources: PitchBook, Wall Street Journal, SEC Filings, Company Press Releases, fiercebiotech.com, PE HUB, and biospace.com 14

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Monthly Healthcare Review May 2016

Company NameLast

Financing Date

HQ Location Round Description

Last Financing

Size (Millions)

Lead Investor(s)

Private Equity Placements and Venture Capital RoundsThe following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

Encore Vision 12-May-16 Fort Worth, TX Later Stage VC The company provides an eye drop treatment designed to reduce eye lens stiffness and make the lens less viscous to restore flexibility, allowing the lens to thicken in the center during an attempt to focus on nearby objects.

4.50 Bios Partners, Cowtown Angels, North Avenue Investments, Steelhead Capital Management, TECH Fort Worth, U.S. Department of Health and Human Services

BluPanda 12-May-16 Pittsburgh, PA Angel Provider of robotics management services for the healthcare industry. The company automates the management of the logistics of delivering patient care in healthcare facilities.

2.09 Undisclosed

Arthro Therapeutics 12-May-16 Malmo, Sweden Seed Round Provider of an online evidence-based osteoarthritis treatment program. 1.00 Hampus Jakobsson, Lean Investments, Lund University Innovation System, Sophia Bendz, StartUp Health

Viriom 11-May-16 San Diego, CA Later Stage VC Developer of therapies against life threatening infections such as the HIV (human immunodeficiency virus) and Heptatis B virus.

4.70 ChemRar High Tech Center, Skolkovo Foundation, Torrey Pines Investment

Compiled By: Terence YenSources: PitchBook, Wall Street Journal, SEC Filings, Company Press Releases, fiercebiotech.com, PE HUB, and biospace.com 15

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Monthly Healthcare Review May 2016

Company NameLast

Financing Date

HQ Location Round Description

Last Financing

Size (Millions)

Lead Investor(s)

Private Equity Placements and Venture Capital RoundsThe following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

Umbie Health 11-May-16 Middletown, CT Early Stage VC The company provides a platform to manage patients, organize dental records and handle scheduling and billing.

2.59 Angel Investor Forum, Atlas Venture, Connecticut Innovations

Rigenerand 11-May-16 Medolla, Italy Early Stage VC The company develops and produces biomedical tools to empower the ex-vivo phase of stem cells expansion, combining the need of high cell yield with innovative biocompatible materials.

9.86 Principia, RanD, University of Modena and Reggio Emilia

Polyneuron Pharmaceuticals

11-May-16 Basel, Switzerland Seed Round Developer of a new drug class for the treatment of autoimmune disorders, which enables the design of drugs that selectively inactivate disease-causing autoantibodies, while leaving the immune system intact.

3.22 CTI Invest, Eva Capital, Gebert Rüf Foundation, Neuromuscular Research Association Basel, Swiss Foundation, Venture kick, Zürcher Kantonalbank

Pillar Biosciences 11-May-16 Natick, MA Early Stage VC The company provides a targeted sequencing technology platform and a proprietary data analysis toolkit for Next Generation Sequencing (NGS) based oncology testing.

18.00 ORI Capital

OxStem 11-May-16 Oxford, United Kingdom

Angel The company specializes in the development of cell programming therapies for the treatment of age-related conditions such as dementia, heart failure, macular degeneration, diabetes and oncology.

24.15 Bob Duggan, J. Craig Venter, Mahkam Zanganeh

G1 Therapeutics 11-May-16 Durham, NC Later Stage VC Developer of small molecule therapeutic agents to protect the bone marrow from radiation or chemotherapy damage.

47.00 Cormorant Asset Management

ExThera Medical 11-May-16 Martinez, CA Angel The company develops and offers medical devices for the treatment of bloodstream infections and pathogen-reduction in blood banking.

15.29 Undisclosed

Compiled By: Terence YenSources: PitchBook, Wall Street Journal, SEC Filings, Company Press Releases, fiercebiotech.com, PE HUB, and biospace.com 16

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Monthly Healthcare Review May 2016

Company NameLast

Financing Date

HQ Location Round Description

Last Financing

Size (Millions)

Lead Investor(s)

Private Equity Placements and Venture Capital RoundsThe following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

Vaccitech 10-May-16 Oxford, United Kingdom

Seed Round Developer of vaccines. The company provides a vaccine for the treatment of prostate cancer by turning the immune system against the disease.

14.29 Oxford Sciences Innovation, Oxford Spin-out Equity Management

SynGen 10-May-16 Sacramento, CA Later Stage VC The company manufactures products that are single use disposable cartridges to capture stem and progenitor cells from peripheral and umbilical cord blood, bone marrow and adipose tissue.

2.00 Bay City Capital, General Electric Capital

Simplee 10-May-16 Palo Alto, CA Later Stage VC The company offers an application that enables consumers to receive detailed breakdowns of their medical bills, confirmation of insurance coverage or deductible and the ability to pay by credit, debit or FSA/HSA card.

20.00 Social Capital

Owloutcomes 10-May-16 Bothell, WA Angel Developer of a software for mental-health professionals. The company provides software-as-a-service enabling healthcare providers to monitor patient outcomes over time.

0.33 Undisclosed

NeuSpera Medical 10-May-16 Santa Clara, CA Angel The company develops an implantable neuromodulation device using mid-field powering techniques to improve the lives of patients suffering from chronic illness.

8.00 Windham Venture Partners

Nanoly Bioscience 10-May-16 Denver, CO Early Stage VC The company provides a polymer that may be blended with any protein-based vaccine at any point in the vaccine delivery chain.

1.08 Undisclosed

Muse Bio 10-May-16 Denver, CO Early Stage VC Developer and provider of a genome engineering technology. The company provides a benchtop device that will give any researcher the ability to construct tens of thousands of rationally engineered strains.

6.04 NanoDimension, Small Business Innovation Research, Spruce Capital Partners

Compiled By: Terence YenSources: PitchBook, Wall Street Journal, SEC Filings, Company Press Releases, fiercebiotech.com, PE HUB, and biospace.com 17

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Monthly Healthcare Review May 2016

Company NameLast

Financing Date

HQ Location Round Description

Last Financing

Size (Millions)

Lead Investor(s)

Private Equity Placements and Venture Capital RoundsThe following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

Insulete 10-May-16 Madison, WI Angel The company offers gene therapy delivered through an intravenous injection that utilizes DNA sequencing to promote the activation of insulin gene to help curb Type-1 diabetes.

0.30 Jeffrey Rusinow, Juvenile Diabetes Research Foundation, Roche Organ Transplantation Research Foundation

HealthiPASS 10-May-16 Naperville, IL Early Stage VC The company develops patient centric payment systems which connects consumers to healthcare service providers.

1.08 Beverly Capital, HealthX Ventures, MPG Equity Partners, OCA Ventures

EvOx Therapeutics 10-May-16 Oxford, United Kingdom

Seed Round The company develops therapeutics based on key aspects of EV-based nucleic acid and protein delivery technology by leveraging proprietary targeting technology, manufacturing processes and purification methods.

14.29 Oxford Sciences Innovation

Evariant 10-May-16 Farmington, CT Later Stage VC The company helps hospitals and health care systems accelerate provider referral and patient volume growth across service lines through the use of a combination of CRM, marketing automation, data integration services and analytics.

42.34 Dignity Health, Health Enterprise Partners, Lightspeed Venture Partners, McKesson Ventures, Salesforce Ventures, The Goldman Sachs Group

Compiled By: Terence YenSources: PitchBook, Wall Street Journal, SEC Filings, Company Press Releases, fiercebiotech.com, PE HUB, and biospace.com 18

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Monthly Healthcare Review May 2016

Company NameLast

Financing Date

HQ Location Round Description

Last Financing

Size (Millions)

Lead Investor(s)

Private Equity Placements and Venture Capital RoundsThe following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

Aptinyx 10-May-16 Evanston, IL Early Stage VC Developer of drugs for disorders of the brain and nervous system. The company specializes in the research and development of drugs for neuropathic pain, post-traumatic stress disorder, traumatic brain injuries and migraines.

65.00 New Leaf Venture Partners

WiserTogether 9-May-16 Washington, DC Later Stage VC The company provides healthcare treatment comparison tools for personalized & shared decision making for consumers helping them identify treatments based on personal financial and clinical factors.

2.48 Undisclosed

TinyKicks 9-May-16 Irvine, CA Angel Provider of a fetal activity monitoring wearable device. The company's system informs about the fetal movement to predict and guide healthy pregnancy outcomes.

0.50 BioAccel, EvoNexus

Medical Imaging Partnership

9-May-16 Crawley, United Kingdom

PE Growth / Expansion

The company provides customers with radiology equipment (MRI, CT Scan, X-Ray, Ultrasound), patient referral and triage management, radiology reporting and clinical support into patient management.

17.15 Apposite Capital

AC Immune 9-May-16 Lausanne, Switzerland

Later Stage VC Developer of disease prevention technology platforms. The company designs, discovers and develops therapeutic and diagnostic products for diseases of protein misfolding.

44.29 dievini Hopp BioTech, EPFL Innovation Park, Fidelity Investments

VisionGate 6-May-16 Phoenix, AZ Later Stage VC Developer of 3D cell image analysis technology for lung cancer detection applications. The company’s products are used for early cancer detection, therapy monitoring and drug discovery applications.

11.18 GreyBird Ventures

MetaModix 6-May-16 Plymouth, MN Angel Developer of surgical and medical instruments. The company develops minimally invasive therapies for the treatment of metabolic disorders such as Type-2 diabetes and obesity.

0.14 Antipodean Advisors

Cardinal Spine 6-May-16 Louisville, KY Angel The company manufactures a vertebral body replacement device to replace a diseased or damaged vertebral body or for reconstruction of the cervical spine in skeletally mature patients.

0.75 Undisclosed

AthGene 6-May-16 Copenhagen, Denmark

Angel The company offers the public diet charts and fitness regimes, as well as access to interpretations of their specific gene variants, so that they may be better informed as to how they can more efficiently try to lead a healthy and balanced lifestyle.

Undisclosed Go Grow, Jørgen Balle Olesen, Magnus Kjøller, Thinkubator

Compiled By: Terence YenSources: PitchBook, Wall Street Journal, SEC Filings, Company Press Releases, fiercebiotech.com, PE HUB, and biospace.com 19

Page 20: May 2016 MiR - BioEnterprise · 2016-09-25 · Medicaid Services), as well as filtering tools, to help patients review providers of specialized care. 17.85 Pritzker Group Venture

Monthly Healthcare Review May 2016

Company NameLast

Financing Date

HQ Location Round Description

Last Financing

Size (Millions)

Lead Investor(s)

Private Equity Placements and Venture Capital RoundsThe following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

ACT Genomics 6-May-16 Taipei City, Taiwan Early Stage VC The company implements next generation sequencing and multiplex molecular testing platform, coupling with bioinformatics tool, curated proprietary databases and data visualization technologies to address the key challenges in cancer treatments.

12.50 CDIB Capital, Eminent Venture Capital, Hotung Investment Holdings, Hua Nan Venture Capital, President International Development, UMC Capital

The Eye Machine 5-May-16 Indian Wells, CA Angel The company develops a medical device to treat macular degeneration by condensing current from direct current barriers in order to deliver energy around the eye, mitigating the effects of age-related macular degeneration and diabetic retinopathy.

0.17 Undisclosed

Soundbite Medical Solutions

5-May-16 Sherbrooke, Canada Seed Round The company designs, develops and commercializes a proprietary shockwave device and generator technology delivered within the cardiovascular system to treat chronic total occlusions.

2.40 Anges Québec, Marc Leroux, Sherbrooke Innopole

PNP Therapeutics 5-May-16 Birmingham, AL Later Stage VC The company engages in research and development of proprietary products and technology for cancer treatment which includes prostate cancer, breast tumor, colon cancer and other oncological problems.

0.29 Greer Capital Advisors, Phase 1 Holdings, Vulcan Medical Ventures

Mindshare Medical 5-May-16 San Juan Capistrano, CA

Seed Round The company develops data analytics software by utilizing medical imaging technology to empower clinicians and healthcare providers, thereby bringing big data to personalized medicine.

2.00 Frost Data Capital, Westway Capital

Blueberry Therapeutics 5-May-16 Alderley Edge, United Kingdom

Early Stage VC Developer of innovative nanomedicines for the treatment of bacterial infection and inflammation. It also develops therapies to tackle the healthcare needs of antibiotic resistance in bacterial infection by neutralising resistance in combination with standard antibiotics.

4.29 Catapult Ventures Group, InClin Investments

Compiled By: Terence YenSources: PitchBook, Wall Street Journal, SEC Filings, Company Press Releases, fiercebiotech.com, PE HUB, and biospace.com 20

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Monthly Healthcare Review May 2016

Company NameLast

Financing Date

HQ Location Round Description

Last Financing

Size (Millions)

Lead Investor(s)

Private Equity Placements and Venture Capital RoundsThe following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

Acer Therapeutics 5-May-16 Cambridge, MA Later Stage VC Developer of pharmaceutical products for specialty orphan diseases. The company's business strategy is to repurpose and reformulate existing drugs for orphan diseases with significant unmet medical need.

8.15 Bukwang Pharmaceuticals Co., TVM Capital

Perfect Search 4-May-16 Orem, UT Angel The company's software allows users to index and search a variety of data - both unstructured and structured - using an algorithm.

0.08 Jonathan Zinsmeyer

NurseBuddy 4-May-16 Tampere, Finland Early Stage VC The company offers a communication tool for all stakeholders in the home care loop such as families, clients, care providers, public nurses and carers.

0.74 Mikko Silventola, Reaktor Ventures, Startupbootcamp, Tekes

Lumicell 4-May-16 Waltham, MA Later Stage VC The company develops an intraoperative imaging system which includes a margin-targeted injectable imaging agent and hand-held imaging device that gives surgeons real-time visual feedback of residual cancer in the tumor bed.

6.77 David Furneaux, Kodiak Venture Partners, National Institutes of Health, National Science Foundation

Isommune 4-May-16 Avila Beach, CA Angel The company specializes in research and development of cancer therapeutics and vaccinations.

0.28 Undisclosed

AcceleDent 4-May-16 Bellaire, TX Later Stage VC The company offers a system that reduces treatment duration for wearing braces by applying pulsing forces in combination with standard orthodontics to move teeth faster through accelerated bone remodeling.

12.00 HealthpointCapital, Houston Angel Network, Houston Technology Center, Piper Jaffray, S3 Ventures, Texas Emerging Technology Fund

Compiled By: Terence YenSources: PitchBook, Wall Street Journal, SEC Filings, Company Press Releases, fiercebiotech.com, PE HUB, and biospace.com 21

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Monthly Healthcare Review May 2016

Company NameLast

Financing Date

HQ Location Round Description

Last Financing

Size (Millions)

Lead Investor(s)

Private Equity Placements and Venture Capital RoundsThe following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

Symbiomix Therapeutics

3-May-16 Newark, NJ Early Stage VC The company develops anti-infective drugs that have a major impact on women’s health outcomes and address serious health needs in the communities.

6.00 Enterprise Development Center, F-Prime Capital Partners, HBM Partners, OrbiMed Advisors, Square 1 Bank

Spinal Simplicity 3-May-16 Overland Park, KS PE Growth / Expansion

Developer of spinal devices. The company offers inter-laminar fusion devices to treat complex spinal and orthopedic conditions.

Undisclosed Enterprise Center of Johnson County, Nueterra, U.S. Food and Drug Administration

Orchard Therapeutics 3-May-16 London, United Kingdom

Early Stage VC Developer of ex-vivo gene therapies for rare diseases. The company develops transformative gene therapies for children with life-threatening orphan diseases.

30.01 F-Prime Capital Partners, UCL Business, University College London

Nuritas 3-May-16 Dublin, Ireland Early Stage VC The company specializes in nutritional-bioinformatics and engages in discovery and development of novel peptides that have specific therapeutic benefits.

2.27 New Protein Capital

Envera Health 3-May-16 Richmond, VA Early Stage VC The company develops a care management system that addresses various health issues related to telemonitoring and patient safety.

14.00 Harbert Growth Partners, New Richmond Ventures, Noro-Moseley Partners

Drazil Foods 3-May-16 Lafayette, CA Angel Producer of health drinks for children. The company produces health drinks made from herbal tea and other flavoring substances for children.

0.35 Two Bridges Capital

Compiled By: Terence YenSources: PitchBook, Wall Street Journal, SEC Filings, Company Press Releases, fiercebiotech.com, PE HUB, and biospace.com 22

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Monthly Healthcare Review May 2016

Company NameLast

Financing Date

HQ Location Round Description

Last Financing

Size (Millions)

Lead Investor(s)

Private Equity Placements and Venture Capital RoundsThe following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

CareCloud 3-May-16 Miami, FL Later Stage VC The company delivers an integrated software suite to maximize physician practice performance, with tools for managing charts, revenue cycles, electronic health records, online communities and secure patient portals.

15.01 Adams Street Partners, Dot Capital, Hercules Capital, Individual Investor, Intel Capital, Norwest Venture Partners, Tenaya Capital

Axiogenesis 3-May-16 Cologne, Germany Later Stage VC The company engages in production and use of transgenic and physiologically relevant tissues and cells derived from induced pluripotent stem cells and embryonic stem cells in drug development.

Undisclosed Donghai Securities, High-Tech Gründerfonds, V+ Management

ViewPoint Therapeutics 2-May-16 San Francisco, CA Early Stage VC The comapny provides medical services and operates a biotechnology firm dedicated to the development of treatments for diseases of protein mis-folding, including cataracts.

3.98 Lagunita BioSciences, Mission Bay Capital

Turnpoint Medical Devices

2-May-16 Basking Ridge, NJ Angel Developer of non-invasive medical devices. The company engages in developing an infusion pump system for home infusion and cancer clinic markets.

6.25 Undisclosed

MyDentistChoice 2-May-16 Hyderabad, India Seed Round The company is focused on the direct sales and distribution of professional dental equipment for private practice, dental hospital or distribution center from different manufacturers.

0.15 T-hub

Homology Medicines 2-May-16 Lexington, MA Early Stage VC Developer of genetic medicines. The company is a developer of gene-editing and gene therapy treatments for patients with rare diseases.

43.50 4:59 Initiative, 5AM Ventures, ARCH Venture Partners, Deerfield Management, Temasek Holdings

Compiled By: Terence YenSources: PitchBook, Wall Street Journal, SEC Filings, Company Press Releases, fiercebiotech.com, PE HUB, and biospace.com 23

Page 24: May 2016 MiR - BioEnterprise · 2016-09-25 · Medicaid Services), as well as filtering tools, to help patients review providers of specialized care. 17.85 Pritzker Group Venture

Monthly Healthcare Review May 2016

Company NameLast

Financing Date

HQ Location Round Description

Last Financing

Size (Millions)

Lead Investor(s)

Private Equity Placements and Venture Capital RoundsThe following table includes institutionally placed private equity financings for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

GrayBug 2-May-16 Baltimore, MD Early Stage VC The company's pipeline products cover major eye indications that might lead to blindness, including wet age-related macular degeneration (AMD), glaucoma, and corneal graft rejection.

44.50 Deerfield Management

Convexity Scientific 2-May-16 Westport, CT Early Stage VC Provider of respiratory medical devices. The company is a provider of nebulizer devices for treatment of respiratory diseases. It also provides parts for nebulizers.

0.30 Connecticut Innovations

Compiled By: Terence YenSources: PitchBook, Wall Street Journal, SEC Filings, Company Press Releases, fiercebiotech.com, PE HUB, and biospace.com 24

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Monthly Healthcare Review May 2016

Acquirer Target HQ Location Date DescriptionTransaction

Value (Millions)

Nokia Withings Issy-les-Moulineaux, France

31-May-16 Developer of digital health and wellness smart devices and applications. The company offers software and devices that enable people to monitor and track their personal health data.

192.71

HIL Applied Medical HIL US Sparks, NV 26-May-16 Developer of a nano-engineered target. The company provides short-pulse laser proton based physics target for the research and cancer therapy.

Undisclosed

China Wah Yan Healthcare

Rui Kang Pharmaceutical Group Investments

Hong Kong, Hong Kong

25-May-16 The company develops, manufactures, sells and distributes consumer cosmetics, health related products, pharmaceutical products, health supplement wine, dental materials and equipment through its subsidiaries.

10.25

IMS Health Privacy Analytics Ottawa, Canada 25-May-16 Developer of data-anonymization software which enables users of health data to quantify, assess and manage risks when disclosing health data for secondary purposes.

Undisclosed

Dr. Maisch, Buchi, Hichrom and S*Pure

W.R. Grace (Chromatography Instruments, Columns, Related Lab Products Businesses)

Columbia, MD 24-May-16 Provider of chromatography instruments. The business offers high-performance liquid chromatography columns, preparative columns and packing equipment and services.

Undisclosed

Scapa Group EuroMed (Wound Care Solution)

Orangetown, NY 24-May-16 Developer and manufacturer of hydrocolloid-based, consumer wound-care products such as hydrosoft adhesives, professional dressings, ostomy accessories and consumer bandages focusing on foot care, first aid and personal care.

42.00

Brownmed Joslin Orthopedic Gear

Brisbane, CA 23-May-16 Manufacturer of ergonomically designed stretch arm slings for hospitals, clinics, sport medicine specialists and orthopedic surgeons, sports teams, rehab and occupational therapists, schools and universities, the military, nursing and home care services.

Undisclosed

Recipharm Cirrus Pharmaceuticals

North Carolina 23-May-16 The company provides research and development services including physical and chemical characterization, formulation development, stability testing, container/closure selection, process development, scale-up and technical transfer for inhaled, nasal, oral, parenteral, topical and trans-dermal products.

Undisclosed

Mergers and AcquisitionsThe following table includes mergers and acquisitions for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

Compiled By: Terence YenSources: PitchBook, Wall Street Journal, SEC Filings, Company Press Releases, fiercebiotech.com, PE HUB, and biospace.com 25

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Monthly Healthcare Review May 2016

Acquirer Target HQ Location Date DescriptionTransaction

Value (Millions)

Mergers and AcquisitionsThe following table includes mergers and acquisitions for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

Canary Health bLife Santa Monica, CA 19-May-16 Provider of a mobile application for stress management. The company provides a biofeedback application that assesses users' frame of mind, provides training programs for meditation and visualization and tracks their progress.

Undisclosed

Alvotech Alvotech Germany Juelich, Germany 18-May-16 Provider of biotechnology services. The company is engaged in the development of novel therapeutics for the treatment of autoimmune diseases like rheumatoid arthritis, Crohn`s disease, psoriasis and multiple sclerosis and for cancer.

Undisclosed

Nanjing Fullshare Asset Management

Shenzhen Anke High-tech Co

Shenzhen, China 17-May-16 Provider of research and development, manufacturing, sales and services of medical equipment. The company's main products are in the medical imaging, informatics, electronics and therapeutics fields.

21.61

HudlHealth Seratis Philadelphia, PA 17-May-16 Provider of a mobile messaging application that enables doctors, nurses and other healthcare providers to communicate with each other through text, images and videos.

Undisclosed

Gilead Sciences Nimbus Apollo Cambridge, MA 17-May-16 The company is engaged in research and development of various drugs that provides treatments for certain liver diseases such as non-alcoholic steatohepatitis (NASH) and others.

1200.00

Mylan Renaissance Acquisition (Generics Business)

Longueuil, Canada 16-May-16 The company manufactures topical drugs applied directly to the skin which are prescribed for dermatological conditions.

1000.00

Zimmer Biomet Cayenne Medical Scottsdale, AZ 16-May-16 Provider of arthroscopic surgery products. The company offers the AperFix System that enables the surgeons to perform anterior cruciate ligament (ACL) reconstruction using the hamstring and various soft tissue grafts.

Undisclosed

Amryt SomPharmaceuticals

Epalinges, Switzerland

13-May-16 Provider of a somatostatin analogue therapy for rare diseases. The company is developing novel anti-tumour somatostatin analogue (SSA) peptide medicines and diagnostics for patients with rare diseases.

Undisclosed

McKesson Laboratory Supply Company

Louisville, KY 13-May-16 Distributor of clinical products for the alternative-care market in the United States. The company offers tools, reagents, office set-up, diagnostic kits, gloves, general lab supplies, equipment and specimen-collection products.

Undisclosed

Compiled By: Terence YenSources: PitchBook, Wall Street Journal, SEC Filings, Company Press Releases, fiercebiotech.com, PE HUB, and biospace.com 26

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Monthly Healthcare Review May 2016

Acquirer Target HQ Location Date DescriptionTransaction

Value (Millions)

Mergers and AcquisitionsThe following table includes mergers and acquisitions for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

Diasorin Focus Diagnostics Cypress, CA 13-May-16 Developer of molecular and immunology products, including tests for diseases such as West Nile Virus, Rickettsia, and Legionella, for hospitals and commercial laboratories worldwide.

300.00

BioTelemetry Virtualscopics Rochester, NY 12-May-16 Provider of clinical trial imaging services for drug and medical device development. The company develops imaging tools used in areas such as oncology, rheumatoid arthritis, osteoarthritis, neurology and cardiovascular studies.

15.50

Avant Diagnostics Theranostics Health Gaithersburg, MD 11-May-16 Developer of molecular diagnostic technology for the personalized medicine sector. The company is focused on two business lines: providing protein-based translational research services for biomarker and companion diagnostic purposes; and developing clinical tests focused upon molecular targeted therapeutic approaches.

Undisclosed

Jazz Phamceuticals Alizé Pharma II Écully, France 11-May-16 Developer of therapeutic products for the treatment of diabetes, cancer and metabolic diseases.

20.40

AC Pio gb Implantat-Technologie

Essen, Germany 10-May-16 Manufacturer of implant materials for the medical and dental industry. The company specializes in manufacturing implants made from cobalt-chrome alloy for hips, knees, shoulders and teeth that can remain in the human body for years without failure.

Undisclosed

True Nature Holding Integrity Compounding Pharmacy

Atlanta, GA 9-May-16 Manufacturer of compounding pharmaceutical products. The company designs and develops compounding pharmaceutical products. It offers bio-identical hormone replacement therapy products, wellness compounding products and transdermal pain creams.

Undisclosed

Lumin Medical Implementing Technologies (Online Reputation Management Business)

Franklin, WI 9-May-16 The business offers online reputation management software that deliver automated patient satisfaction surveys, brand marketing analytics, integrated physician performance publishing and content tracking across all of the major physician review sites.

Undisclosed

DePuy Orthopaedics BioMedical Enterprises

San Antonio, TX 9-May-16 Developer of orthopedic shape memory implant technology for bone fixation, which offers controlled compression of vertebral segments at the time of surgery to enhance fixation and graft retention, as well as offers Nitinol metal implants for musculoskeletal fixation.

Undisclosed

Compiled By: Terence YenSources: PitchBook, Wall Street Journal, SEC Filings, Company Press Releases, fiercebiotech.com, PE HUB, and biospace.com 27

Page 28: May 2016 MiR - BioEnterprise · 2016-09-25 · Medicaid Services), as well as filtering tools, to help patients review providers of specialized care. 17.85 Pritzker Group Venture

Monthly Healthcare Review May 2016

Acquirer Target HQ Location Date DescriptionTransaction

Value (Millions)

Mergers and AcquisitionsThe following table includes mergers and acquisitions for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

SciVac Therapeutics VBI Vaccines (VBIV)

Cambridge, MA 6-May-16 Developer of thermostable IM for influenza and measles, thermostable oral for influenza, hepatitis A and shigella and synthetic recombinant for peptide-based influenza and VLP-based cytomegalovirus.

65.70

Legrand Jontek Stockport, United Kingdom

6-May-16 The company develops, installs and supports monitoring systems and provides telecare, telehealth and other such facilities through their monitoring and response centres.

Undisclosed

Blackmores Global Therapeutics Byron Bay, Australia

6-May-16 Provider of herbal medicine formulations. 17.63

PAI Partners Ethypharm France 6-May-16 Developer of drug-delivery technologies. The company partners with pharmaceutical firms with a focus on enhancing the safety and performance of medicines through innovative drug delivery.

855.00

Bioalpha Holdings PT Malindo Herbal Makmur

Selangor, Malaysia 4-May-16 Manufacturer of health-supplement products. Undisclosed

Warburg Pincus DocuTap Sioux Falls, SD 4-May-16 Provider of healthcare technology for urgent care. The company provides software for electronic medical records, practice management software andrevenue cycle management for urgent care and primary care clinics.

Undisclosed

Bioorganic Research Zera Intein Protein Solutions

Barcelona, Spain 3-May-16 Developer and provider of inteins-based biochemical tools. The company develops technology for the production of peptides and recombinant proteinsfor both therapeutic and industrial interest.

1.81

AstraZeneca Takeda Pharmaceutical (Respiratory Business)

Osaka, Japan 3-May-16 The company develops and distributes respiratory medicines and early pipeline products. It also supplies respiratory products, including Alvesco and Omnaris, a steroid that reduces inflammation.

575.00

Free Association Books Stone Checker Software

Radstock, United Kingdom

3-May-16 Provider of medical imaging software for analyzing Urolithiasis and urological diseases.

0.07

Frutarom Industries Dr. Bruno Stellmach

Stadthagen, Germany

3-May-16 The company develops, produces and markets natural extracts, some of which include plant-sourced enzymes for use mainly as raw material (API) in the pharmaceutical market. It provides treatment of liver diseases, digestive problems and prevents infections.

6.01

Compiled By: Terence YenSources: PitchBook, Wall Street Journal, SEC Filings, Company Press Releases, fiercebiotech.com, PE HUB, and biospace.com 28

Page 29: May 2016 MiR - BioEnterprise · 2016-09-25 · Medicaid Services), as well as filtering tools, to help patients review providers of specialized care. 17.85 Pritzker Group Venture

Monthly Healthcare Review May 2016

Acquirer Target HQ Location Date DescriptionTransaction

Value (Millions)

Mergers and AcquisitionsThe following table includes mergers and acquisitions for private and public medical devices, biotechnology, pharmaceuticals, and healthcare companies announced over the previous month.

Halyard Health CORPAK MedSystems

Buffalo Grove, IL 3-May-16 The company offers a wide range of products including CORFLO nasogastric and gastrostomy feeding tubes, FARRELL gastric pressure relief devices, and enteral feeding safety devices to meet the clinical needs of hospitals, nursing homes, and home care.

174.00

Senzime Acacia Designs Maastricht, Netherlands

3-May-16 Developer of medical monitoring devices for patients affected by post-operative complications related to anesthesia and premature extubation.

11.90

Veristat Spero Oncology Bellshill, United Kingdom

2-May-16 Operator of a clinical research organization (CRO) focused on development of oncology products.

Undisclosed

The Clorox Company ReNew Life Formulas

Palm Harbor, FL 2-May-16 Developer and producer of natural health supplements, products and functional foods for digestive health.

290.00

ADG Apotheken-Dienstleistungsgesellschaft

Novodata Számítástechnika

Budapest, Hungary 2-May-16 Provider of pharmacy information systems. The company develops and provides information technology and service concepts to pharmacies.

Undisclosed

DexCom Nintamed Mainz, Germany 2-May-16 Developer of products for the management of diabetes. The company is the developer of a continuous glucose monitoring system for blood sugar and pen needles for administration of insulin.

Undisclosed

Inovio Pharmaceuticals Bioject Medical Technologies

Tigard, OR 2-May-16 Developer and manufacturer of a needle-free injection therapy system. 5.50

Compiled By: Terence YenSources: PitchBook, Wall Street Journal, SEC Filings, Company Press Releases, fiercebiotech.com, PE HUB, and biospace.com 29