ugust 2, 2018 Dear Agent: With great enthusiasm we invite you to participate in the 2019 MIB Agents FACTOR Conference at the Ritz-Carlton, Coconut Grove, Miami, FL, January 25-26, 2019. The FACTOR Conference in now in its third year of bringing together prominent Osteosarcoma experts along with patients and patient advocates from around the world, with the mission to significantly improve osteosarcoma awareness and patient outcomes through collaborative disease management approaches, clinical trials and research. Your sponsorship and participation would be greatly appreciated. If you need any clarification on any aspect of FACTOR, please contact Dr. Matteo Trucco or Ann Graham. We are very appreciative of your work and dedication toward improving the outcomes for those affected by Osteosarcoma. Highlights of last year’s conference and updates are available on our website MIBAgents.org Sincerely, The FACTOR 2018 - Miami Conference Team Matteo Trucco, M.D. Ann Graham Gigi Jeffries, PhD

Dir. Peds Phase 1 Program Founder & President FACTOR Project Manager Assistant Professor, Peds MIB Agents OS Alliance MIB Agents OS Alliance Univesity of Miami, Sylvester CCC

P.S. The MIB Agents OutRunning Osteosarcoma Team will again be participating in the Miami Marathon Sunday Jan 27, 2019. Runners/Walkers will be paired with an OsteoWarrior. If you wish to join us, please click HERE to register with code TEAMMIB19. Proceeds will fund osteosarcoma research. Contact Rebecca Rogers with any questions.

Confirmed Speakers:

Ching Lau, MD, PhD - Jackson Lab Joshua Schiffman, MD - UUtah, Huntsman Cancer Alex Huang, MD, PhD - Case Western Damon Reed, MD - Moffitt Cancer Center Richard Gorlick, MD - MD Anderson Matteo Trucco, MD - Sylvester CCC Wendy A. Rhoades, MD - Texas Children's Albert Cornelius, MD – DeVos Children’s Nicola Mason, DVM – Upenn Vet Lars Wagner, MD, PhD - Duke Ines Lohse, PhD - Sylvester CCC Corrie Painter, PhD – The Broad Institute of MIT & Harvard Katie Greenzang, MD – Harvard & Dana Farber Patrick Thompson, MD - UNC Medical Center

MIB Agents Osteosarcoma Alliance I MIBagents.org PO Box 858 I Barnard, VT I 05031 I info@MIBagents.org I 518.524.3890

FACTOR Speakers 2018 Joshua Schiffman, MD Huntsman Cancer Institute **Keynote Speaker** Associate Professor of Pediatrics MIB OutSmarting Osteo Grant Winner Peter Anderson, MD PhD Cleveland Clinic Pediatric Hematology-Oncology Matteo Trucco, MD University of Miami Sylvester CCC Pediatric Hematology-Oncology R. Lor Randall, MD Huntsman Cancer Institute Director of Sarcoma Services Daniel Prince, MD Memorial Sloan Kettering CC Orthopaedic Oncology Rosandra N. Kaplan, MD National Cancer Institute Head, Tumor Microenvironment Section; Investigator Pediatric Oncology Branch David M. Loeb, MD, PhD Montefiore Medical Center Chief of Pediatric Hematology-Oncology Breelyn Wilky, MD University of Miami Sylvester CCC Hematology/Oncology - Internal Medicine Ramy Ibrahim, MD Parker Institute for Cancer Immunotherapy Vice President of Clinical Development Shree Venkat, MD University of Miami Sylvester CCC Vascular & Interventional Radiology

Katherine Janeway, MD Dana-Farber Cancer Institute Senior Physician and Clinical Director, Solid Tumor Center Nicola Mason, DVM, PhD University of Pennsylvania School of Veterinary Medicine Associate Professor of Medicine & Pathobiology Valerae Lewis, MD MD Anderson Cancer Center Professor and Chair, Orthopaedic Oncology Darcy Kerr, MD University of Miami Sylvester CCC Pathology Paul Meyers, MD Memorial Sloan Kettering CC Pediatric Hematology-Oncology Robin Jones, MD The Royal Marsden NHS Foundation Trust Medical Oncologist Raphael Yechieli, MD University of Miami Sylvester CCC Assistant Professor of Radiation Oncology; Assoc Residency Program Director Nabil Ahmed, MD Baylor College of Medicine Pediatric Hematology-Oncology Brian Van Tine, MD, PhD Washington University of St. Louis Assistant Professor of Medicine, Division of Oncology, Section of Medical Oncology Ty Subhawong, MD University of Miami Sylvester CCC Associate Professor of Clinical Radiology

Subree Subramanian, PhD University of Minnesota Subree Lab, Department of Surgery; Associate Professor Dao Nguyen University of Miami Sylvester CCC Professor of Surgery and Chief, Thoracic Surgery Section, Division of Cardiothoracic Surgery Timothy Fan, DVM, PhD University of Illinois College of Veterinary Medicine Associate Professor Jonathan Trent, MD, PhD University of Miami Sylvester CCC Professor of Medicine, Co-Director Musculoskeletal Center, Sarcoma Medical Research Program Yoram Unguru, MD, MS Johns Hopkins Berman Institute of Bioethics Division of Pediatrics Hematology-Oncology Kenneth Goodman, PhD University of Miami Bioethics Program, Founder and Director - Bioethics and Health Policy Donna Ludwinski Solving Kids Cancer Director of Research Programs Mary Katherine Clarke QuadW, Osteosarcoma Institute Advisory Director & Exec Board Raymond Rodriguez-Torres Live Like Bella Chairman Ann Graham MIB Agents President & Founder

MIB Agents FACTOR Speakers 2017 John Healey, MD Memorial Sloan Kettering CC Chief, Orthopaedic Service Eugenie Kleinerman, MD University of Texas MD Anderson Cancer Center Fan Lai, PhD University of Miami Molecular Biology Human Biology, Cell Biology David M. Loeb, MD, PhD Johns Hopkins Kimmel Assoc Prof Oncology & Pediatrics Dir. Musculoskeletal Tumor Program Agin, Jonathan Maxx Cure Foundation Executive Director General Counsel for cc-TDI Beech, Theresa OsteoMom Logan Spector, PhD University of Minnesota, Masonic Cancer Center, Asst Prof. of Peds, Div. of Epidemiology/Clinical Research Benjamin,Robert MD MD Anderson Professor and Chairman, Department of Sarcoma Oncology Branden Moriarity Assistant Professor, Pediatrics Masonic Cancer Center Center for Genome Engineering University of Minnesota Hallberg, John CEO Children's Cancer Research Fund Alejandro Sweet-Cordero, MD Stanford University School of Medicine, Assoc. Prof. Pediatrics Rosandra N. Kaplan, MD NIH, NCI Investigator Pedis Oncology Branch Head of Tumor Microenvironment Section

Darcy Kerr, MD University of Miami Sylvester CCC Pathology Paul S. Meltzer, MD, PhD NIH, NCI. CCR Chief, Genetics Branch Trent, Jonathan, MD, PhD University of Miami Sylvester CCC, Co-Director Musculoskeletal Center, Sarcoma Medical Research Marina Neyssa, MD Stanford University School of Medicine, Assoc. Prof. Pediatric Hematology/Oncology Dao M. Nguyen, MD University of Miami Sylvester CCC Professor of Surgery and Chief Thoracic Surgery Janet Panoch Adjunct Faculty at Ivy Tech, OsteoMom William F. Pirl, MD, MPH University of Miami Sylvester CCC Psychiatry & Neurology Damon R. Reed, MD Johns Hopkins All Children's Hospital Pediatric Hematology-Oncology Andrew Rosenberg,MD University of Miami Sylvester CCC Chief of Anatomic Pathology, Dir. Bone & Soft Tissue Service Howard G. Rosenthal, MD University of Kansas Medical Center, Assistant Professor Orthopedic Surgery Joshua Schiffman, MD University of Utah Professor Dept of Pediatrics Swords, Ronan MD, PhD University of Miami Sylvester CC, Asst Prof of Medicine, Co-Chair Laura SobiechZach Sobiech Osteosarcoma Research Fund, Children's Cancer Research Fund

Chand Khanna, DVM, PhD NIH, Senior Scientist Research Biology and Treatment of Metastasis Ellen Spear President, Phoebe's Phriends Matteo Trucco, MD University of Miami Sylvester CCC Pediatric Hematology-Oncology Claes Wahlelstedt, MD, PhD University of Miami, Assoc Dean Therapeutic Innovation, Dir. Center for Therapeutic Innovation, Prof. Psychiatry & Behavioral Sciences Breelyn Wilky, MD University of Miami Sylvester CCC Hematology/Oncology - Internal Medicine Raphael Yechieli, MD University of Miami Sylvester CCC Assistant Professor of Radiation Oncology; Assoc Residency Program Director Ann Graham MIB Agents President & Founder

AGENT$5,000

SPECIAL AGENT$10,000

HERO$25,000

SUPERHERO$50,000

CHAMPION$100,000

Speaker’s Dinner(off-site)

Designate a Speaker 20 minutes

Complimentary Registration Passes

Exhibitor Space (6’ skirted table)

Address All Attendees(5 minutes)

“Sponsored By” in Conference Title

Logo on Conference Website

Email Blast Listing

Access to Email List

Conference Video Recognition

Conference Program Ad

Promotion on Social Media Channels

Oral Recognition

Literature included in all tote bags

Logo on Shirt

Logo on Tote Bag

2 Full Pages 1 Full Page 1/2 Page 1/4 Page 1/4 Page

5x 3x 2x 1x 1x

All 3x 2x 1x 1x

5 2 1 1

HOST AGENT : $1,500We’re seeking individuals and companies interested in making a donation that will help offset the costs

for a family to attend the conference.

Sponsorship Helps Cover: Room, Food and Beverage, and Registration for a osteo family.

100K raised and donated yearly to osterosarcoma research

1and only osteosarcoma conference

FACTOR by the Numbers

80 Speakers and Medical Professionals

85 Patient / Family / Caregivers

25 Osteosarcoma Warriors

205 total attendence

24 Outrunning Osteosarcoma team runners at the Miami Marathon

I

Mail Donations to:MIB Agents, PO Box 858,

Barnard, VT 05031518.524.3890

www.MIBagents.org