Embed Size (px)
Citation preview
0 60
1.2e+08
1.4e+08
1.6e+08
1.8e+08
2.0e+08
2.2e+08
alanine − DAY DAY 2
DOSE_MG_KG
amou
nt
8 8
Mann−Whitney U: : 0.51 (for DOSE_MG_KG )
●
0 60
1.2e+08
1.4e+08
1.6e+08
1.8e+08
2.0e+08
2.2e+08
alanine − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.00016 *(for DOSE_MG_KG )
●
0 60
1.2e+08
1.4e+08
1.6e+08
1.8e+08
2.0e+08
2.2e+08
alanine − DAY DAY 5
DOSE_MG_KGam
ount
8
8
Mann−Whitney U: : 0.007 (for DOSE_MG_KG )
0 60
1e+06
2e+06
3e+06
4e+06
asparagine − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.19 (for DOSE_MG_KG )
●
0 60
1e+06
2e+06
3e+06
4e+06
asparagine − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.021 (for DOSE_MG_KG )
●
0 60
1e+06
2e+06
3e+06
4e+06
asparagine − DAY DAY 5
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.021 (for DOSE_MG_KG )
0 60
2.5e+07
3.0e+07
3.5e+07
4.0e+07
4.5e+07
5.0e+07
aspartate − DAY DAY 2
DOSE_MG_KG
amou
nt
88
Mann−Whitney U: : 0.65 (for DOSE_MG_KG )
0 60
2.5e+07
3.0e+07
3.5e+07
4.0e+07
4.5e+07
5.0e+07
aspartate − DAY DAY 3
DOSE_MG_KG
amou
nt8
8
Mann−Whitney U: : 0.65 (for DOSE_MG_KG )
●
0 60
2.5e+07
3.0e+07
3.5e+07
4.0e+07
4.5e+07
5.0e+07
aspartate − DAY DAY 5
DOSE_MG_KGam
ount
8
8
Mann−Whitney U: : 0.13 (for DOSE_MG_KG )
0 60
1000000
1500000
2000000
beta.alanine − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.16 (for DOSE_MG_KG )
0 60
1000000
1500000
2000000
beta.alanine − DAY DAY 3
DOSE_MG_KG
amou
nt
8 8
Mann−Whitney U: : 0.96 (for DOSE_MG_KG )
0 60
1000000
1500000
2000000
beta.alanine − DAY DAY 5
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.010 (for DOSE_MG_KG )
0 60
50000
100000
150000
200000
250000
300000
350000
400000
X2.aminobutyrate − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.010 (for DOSE_MG_KG )
0 60
50000
100000
150000
200000
250000
300000
350000
400000
X2.aminobutyrate − DAY DAY 3
DOSE_MG_KG
amou
nt 8
8
Mann−Whitney U: : 0.00016 *(for DOSE_MG_KG )
0 60
50000
100000
150000
200000
250000
300000
350000
400000
X2.aminobutyrate − DAY DAY 5
DOSE_MG_KGam
ount
8
8
Mann−Whitney U: : 0.00016 *(for DOSE_MG_KG )
0 60
1e+06
2e+06
3e+06
4e+06
creatine − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.19 (for DOSE_MG_KG )
0 60
1e+06
2e+06
3e+06
4e+06
creatine − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.00062 (for DOSE_MG_KG )
0 60
1e+06
2e+06
3e+06
4e+06
creatine − DAY DAY 5
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.00016 *(for DOSE_MG_KG )
●
●
0 60
50000
100000
150000
200000
250000
300000
creatinine − DAY DAY 2
DOSE_MG_KG
amou
nt
6
5
Mann−Whitney U: : 0.8 (for DOSE_MG_KG )
0 60
50000
100000
150000
200000
250000
300000
creatinine − DAY DAY 3
DOSE_MG_KG
amou
nt
5
8
Mann−Whitney U: : 0.17 (for DOSE_MG_KG )
0 60
50000
100000
150000
200000
250000
300000
creatinine − DAY DAY 5
DOSE_MG_KGam
ount
7
8
Mann−Whitney U: : 0.46 (for DOSE_MG_KG )
0 60
1e+06
2e+06
3e+06
4e+06
5e+06
6e+06
cysteine − DAY DAY 2
DOSE_MG_KG
amou
nt
88
Mann−Whitney U: : 0.8 (for DOSE_MG_KG )
0 60
1e+06
2e+06
3e+06
4e+06
5e+06
6e+06
cysteine − DAY DAY 3
DOSE_MG_KG
amou
nt 8
8
Mann−Whitney U: : 0.083 (for DOSE_MG_KG )
0 60
1e+06
2e+06
3e+06
4e+06
5e+06
6e+06
cysteine − DAY DAY 5
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.00016 *(for DOSE_MG_KG )
0 60
2e+06
3e+06
4e+06
5e+06
6e+06
7e+06
8e+06
9e+06
hypotaurine − DAY DAY 2
DOSE_MG_KG
amou
nt
88
Mann−Whitney U: : 0.8 (for DOSE_MG_KG )
●
●
0 60
2e+06
3e+06
4e+06
5e+06
6e+06
7e+06
8e+06
9e+06
hypotaurine − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.28 (for DOSE_MG_KG )
●
0 60
2e+06
3e+06
4e+06
5e+06
6e+06
7e+06
8e+06
9e+06
hypotaurine − DAY DAY 5
DOSE_MG_KGam
ount
8
8
Mann−Whitney U: : 0.10 (for DOSE_MG_KG )
●
0 60
200000
250000
300000
350000
400000
450000
500000
methionine − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.13 (for DOSE_MG_KG )
0 60
200000
250000
300000
350000
400000
450000
500000
methionine − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.015 (for DOSE_MG_KG )
●
0 60
200000
250000
300000
350000
400000
450000
500000
methionine − DAY DAY 5
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.00016 *(for DOSE_MG_KG )
0 60
15000
20000
25000
30000
35000
40000
N.acetylmethionine − DAY DAY 2
DOSE_MG_KG
amou
nt
3
5
Mann−Whitney U: : 0.036 (for DOSE_MG_KG )
●
0 60
15000
20000
25000
30000
35000
40000
N.acetylmethionine − DAY DAY 3
DOSE_MG_KG
amou
nt
6
1
Mann−Whitney U: : 0.86 (for DOSE_MG_KG )
15000
20000
25000
30000
35000
40000
N.acetylmethionine − DAY DAY 5
DOSE_MG_KGam
ount
6
0 60
60000
80000
100000
120000
140000
S.adenosylhomocysteine..SAH. − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.33 (for DOSE_MG_KG )
0 60
60000
80000
100000
120000
140000
S.adenosylhomocysteine..SAH. − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.083 (for DOSE_MG_KG )
0 60
60000
80000
100000
120000
140000
S.adenosylhomocysteine..SAH. − DAY DAY 5
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.028 (for DOSE_MG_KG )
●
0 60
2e+05
3e+05
4e+05
5e+05
6e+05
7e+05
gamma.aminobutyrate..GABA. − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.96 (for DOSE_MG_KG )
0 60
2e+05
3e+05
4e+05
5e+05
6e+05
7e+05
gamma.aminobutyrate..GABA. − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.0030 (for DOSE_MG_KG )
●
0 60
2e+05
3e+05
4e+05
5e+05
6e+05
7e+05
gamma.aminobutyrate..GABA. − DAY DAY 5
DOSE_MG_KGam
ount
8
8
Mann−Whitney U: : 0.0011 (for DOSE_MG_KG )
0 60
2e+07
4e+07
6e+07
8e+07
glutamate − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.083 (for DOSE_MG_KG )
0 60
2e+07
4e+07
6e+07
8e+07
glutamate − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.28 (for DOSE_MG_KG )
0 60
2e+07
4e+07
6e+07
8e+07
glutamate − DAY DAY 5
DOSE_MG_KG
amou
nt 8
8
Mann−Whitney U: : 0.00031 (for DOSE_MG_KG )
●
0 60
6e+06
7e+06
8e+06
9e+06
glutamine − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.28 (for DOSE_MG_KG )
●
●
0 60
6e+06
7e+06
8e+06
9e+06
glutamine − DAY DAY 3
DOSE_MG_KG
amou
nt
88
Mann−Whitney U: : 1 (for DOSE_MG_KG )
0 60
6e+06
7e+06
8e+06
9e+06
glutamine − DAY DAY 5
DOSE_MG_KGam
ount
8
8
Mann−Whitney U: : 0.021 (for DOSE_MG_KG )
0 60
3e+05
4e+05
5e+05
6e+05
7e+05
X5.oxoproline − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.16 (for DOSE_MG_KG )
0 60
3e+05
4e+05
5e+05
6e+05
7e+05
X5.oxoproline − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.00031 (for DOSE_MG_KG )
0 60
3e+05
4e+05
5e+05
6e+05
7e+05
X5.oxoproline − DAY DAY 5
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.00016 *(for DOSE_MG_KG )
●
0 60
3e+06
4e+06
5e+06
6e+06
7e+06
glutathione.oxidized..GSSG. − DAY DAY 2
DOSE_MG_KG
amou
nt
88
Mann−Whitney U: : 0.96 (for DOSE_MG_KG )
●
0 60
3e+06
4e+06
5e+06
6e+06
7e+06
glutathione.oxidized..GSSG. − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.00016 *(for DOSE_MG_KG )
●
0 60
3e+06
4e+06
5e+06
6e+06
7e+06
glutathione.oxidized..GSSG. − DAY DAY 5
DOSE_MG_KGam
ount
8
8
Mann−Whitney U: : 0.028 (for DOSE_MG_KG )
●
0 60
0e+00
2e+06
4e+06
6e+06
8e+06
1e+07
glutathione.reduced..GSH. − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.28 (for DOSE_MG_KG )
0 60
0e+00
2e+06
4e+06
6e+06
8e+06
1e+07
glutathione.reduced..GSH. − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.0030 (for DOSE_MG_KG )
0 60
0e+00
2e+06
4e+06
6e+06
8e+06
1e+07
glutathione.reduced..GSH. − DAY DAY 5
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.083 (for DOSE_MG_KG )
0 60
0
200000
400000
600000
800000
1000000
1200000
ophthalmate. − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.88 (for DOSE_MG_KG )
0 60
0
200000
400000
600000
800000
1000000
1200000
ophthalmate. − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.00016 *(for DOSE_MG_KG )
0 60
0
200000
400000
600000
800000
1000000
1200000
ophthalmate. − DAY DAY 5
DOSE_MG_KGam
ount
8
8
Mann−Whitney U: : 0.00016 *(for DOSE_MG_KG )
3e+05
4e+05
5e+05
6e+05
7e+05
betaine − DAY DAY 2
DOSE_MG_KG
amou
nt
4
0 60
3e+05
4e+05
5e+05
6e+05
7e+05
betaine − DAY DAY 3
DOSE_MG_KG
amou
nt
2
4
Mann−Whitney U: : 0.13 (for DOSE_MG_KG )
0 60
3e+05
4e+05
5e+05
6e+05
7e+05
betaine − DAY DAY 5
DOSE_MG_KG
amou
nt
1
7
Mann−Whitney U: : 0.75 (for DOSE_MG_KG )
●
0 60
4.0e+06
6.0e+06
8.0e+06
1.0e+07
1.2e+07
1.4e+07
1.6e+07
1.8e+07
betaine.aldehyde − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.065 (for DOSE_MG_KG )
0 60
4.0e+06
6.0e+06
8.0e+06
1.0e+07
1.2e+07
1.4e+07
1.6e+07
1.8e+07
betaine.aldehyde − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.00062 (for DOSE_MG_KG )
0 60
4.0e+06
6.0e+06
8.0e+06
1.0e+07
1.2e+07
1.4e+07
1.6e+07
1.8e+07
betaine.aldehyde − DAY DAY 5
DOSE_MG_KGam
ount
8
8
Mann−Whitney U: : 0.00016 *(for DOSE_MG_KG )
0 60
5.0e+06
1.0e+07
1.5e+07
2.0e+07
glycine − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.065 (for DOSE_MG_KG )
●
0 60
5.0e+06
1.0e+07
1.5e+07
2.0e+07
glycine − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.19 (for DOSE_MG_KG )
0 60
5.0e+06
1.0e+07
1.5e+07
2.0e+07
glycine − DAY DAY 5
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.010 (for DOSE_MG_KG )
0 60
4.0e+07
6.0e+07
8.0e+07
1.0e+08
1.2e+08
serine − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.0030 (for DOSE_MG_KG )
0 60
4.0e+07
6.0e+07
8.0e+07
1.0e+08
1.2e+08
serine − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.00031 (for DOSE_MG_KG )
●
0 60
4.0e+07
6.0e+07
8.0e+07
1.0e+08
1.2e+08
serine − DAY DAY 5
DOSE_MG_KGam
ount
8
8
Mann−Whitney U: : 0.00016 *(for DOSE_MG_KG )
0 60
1.0e+07
1.5e+07
2.0e+07
2.5e+07
3.0e+07
threonine − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.0011 (for DOSE_MG_KG )
0 60
1.0e+07
1.5e+07
2.0e+07
2.5e+07
3.0e+07
threonine − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.00031 (for DOSE_MG_KG )
●
0 60
1.0e+07
1.5e+07
2.0e+07
2.5e+07
3.0e+07
threonine − DAY DAY 5
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.00031 (for DOSE_MG_KG )
0 60
500000
1000000
1500000
2000000
X4.guanidinobutanoate − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.010 (for DOSE_MG_KG )
●
0 60
500000
1000000
1500000
2000000
X4.guanidinobutanoate − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.0019 (for DOSE_MG_KG )
0 60
500000
1000000
1500000
2000000
X4.guanidinobutanoate − DAY DAY 5
DOSE_MG_KGam
ount
8
8
Mann−Whitney U: : 0.083 (for DOSE_MG_KG )
0 60
4e+05
6e+05
8e+05
1e+06
histidine − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.23 (for DOSE_MG_KG )
0 60
4e+05
6e+05
8e+05
1e+06
histidine − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.00016 *(for DOSE_MG_KG )
●
0 60
4e+05
6e+05
8e+05
1e+06
histidine − DAY DAY 5
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.00016 *(for DOSE_MG_KG )
0 60
2e+05
4e+05
6e+05
8e+05
X2.aminoadipate − DAY DAY 2
DOSE_MG_KG
amou
nt
88
Mann−Whitney U: : 0.57 (for DOSE_MG_KG )
●
0 60
2e+05
4e+05
6e+05
8e+05
X2.aminoadipate − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.57 (for DOSE_MG_KG )
●
0 60
2e+05
4e+05
6e+05
8e+05
X2.aminoadipate − DAY DAY 5
DOSE_MG_KGam
ount
8
8
Mann−Whitney U: : 0.88 (for DOSE_MG_KG )
0 60
1.0e+07
1.5e+07
2.0e+07
2.5e+07
lysine − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.038 (for DOSE_MG_KG )
0 60
1.0e+07
1.5e+07
2.0e+07
2.5e+07
lysine − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.13 (for DOSE_MG_KG )
0 60
1.0e+07
1.5e+07
2.0e+07
2.5e+07
lysine − DAY DAY 5
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.00062 (for DOSE_MG_KG )
●
●
0 60
20000
25000
30000
35000
40000
45000
50000
pipecolate − DAY DAY 2
DOSE_MG_KG
amou
nt
5
5
Mann−Whitney U: : 0.55 (for DOSE_MG_KG )
0 60
20000
25000
30000
35000
40000
45000
50000
pipecolate − DAY DAY 3
DOSE_MG_KG
amou
nt2
3
Mann−Whitney U: : 0.8 (for DOSE_MG_KG )
●
●
0 60
20000
25000
30000
35000
40000
45000
50000
pipecolate − DAY DAY 5
DOSE_MG_KGam
ount
5
7
Mann−Whitney U: : 0.88 (for DOSE_MG_KG )
0 60
50000
100000
150000
saccharopine − DAY DAY 2
DOSE_MG_KG
amou
nt 6
4
Mann−Whitney U: : 0.11 (for DOSE_MG_KG )
0 60
50000
100000
150000
saccharopine − DAY DAY 3
DOSE_MG_KG
amou
nt
4
6
Mann−Whitney U: : 0.61 (for DOSE_MG_KG )
0 60
50000
100000
150000
saccharopine − DAY DAY 5
DOSE_MG_KG
amou
nt
7
7
Mann−Whitney U: : 0.71 (for DOSE_MG_KG )
0 60
20000
30000
40000
50000
60000
phenylalanine − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.010 (for DOSE_MG_KG )
0 60
20000
30000
40000
50000
60000
phenylalanine − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.028 (for DOSE_MG_KG )
0 60
20000
30000
40000
50000
60000
phenylalanine − DAY DAY 5
DOSE_MG_KGam
ount
8
8
Mann−Whitney U: : 0.13 (for DOSE_MG_KG )
0 60
4e+06
6e+06
8e+06
1e+07
tyrosine − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.28 (for DOSE_MG_KG )
0 60
4e+06
6e+06
8e+06
1e+07
tyrosine − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.083 (for DOSE_MG_KG )
●
0 60
4e+06
6e+06
8e+06
1e+07
tyrosine − DAY DAY 5
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.0011 (for DOSE_MG_KG )
0 60
20000
30000
40000
50000
60000
70000
X5.methylthioadenosine..MTA. − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.13 (for DOSE_MG_KG )
0 60
20000
30000
40000
50000
60000
70000
X5.methylthioadenosine..MTA. − DAY DAY 3
DOSE_MG_KG
amou
nt 7
7
Mann−Whitney U: : 0.00058 (for DOSE_MG_KG )
●
0 60
20000
30000
40000
50000
60000
70000
X5.methylthioadenosine..MTA. − DAY DAY 5
DOSE_MG_KGam
ount
7
5
Mann−Whitney U: : 0.0025 (for DOSE_MG_KG )
0 60
20000
30000
40000
50000
60000
spermidine − DAY DAY 2
DOSE_MG_KG
amou
nt
4 4
Mann−Whitney U: : 1 (for DOSE_MG_KG )
●
●
0 60
20000
30000
40000
50000
60000
spermidine − DAY DAY 3
DOSE_MG_KG
amou
nt
5
3
Mann−Whitney U: : 0.57 (for DOSE_MG_KG )
0 60
20000
30000
40000
50000
60000
spermidine − DAY DAY 5
DOSE_MG_KG
amou
nt
1
4
Mann−Whitney U: : 1 (for DOSE_MG_KG )
●
0 60
2e+04
4e+04
6e+04
8e+04
1e+05
X3.indoxyl.sulfate − DAY DAY 2
DOSE_MG_KG
amou
nt
8 8
Mann−Whitney U: : 0.88 (for DOSE_MG_KG )
●
0 60
2e+04
4e+04
6e+04
8e+04
1e+05
X3.indoxyl.sulfate − DAY DAY 3
DOSE_MG_KG
amou
nt
5
6
Mann−Whitney U: : 0.8 (for DOSE_MG_KG )
0 60
2e+04
4e+04
6e+04
8e+04
1e+05
X3.indoxyl.sulfate − DAY DAY 5
DOSE_MG_KGam
ount
5
5
Mann−Whitney U: : 0.032 (for DOSE_MG_KG )
0 60
2e+04
4e+04
6e+04
8e+04
1e+05
kynurenine − DAY DAY 2
DOSE_MG_KG
amou
nt
42
Mann−Whitney U: : 1 (for DOSE_MG_KG )
●
0 60
2e+04
4e+04
6e+04
8e+04
1e+05
kynurenine − DAY DAY 3
DOSE_MG_KG
amou
nt
6
4
Mann−Whitney U: : 0.26 (for DOSE_MG_KG )
0 60
2e+04
4e+04
6e+04
8e+04
1e+05
kynurenine − DAY DAY 5
DOSE_MG_KG
amou
nt
5
8
Mann−Whitney U: : 0.13 (for DOSE_MG_KG )
0 60
1500000
2000000
2500000
3000000
3500000
tryptophan − DAY DAY 2
DOSE_MG_KG
amou
nt
88
Mann−Whitney U: : 0.44 (for DOSE_MG_KG )
0 60
1500000
2000000
2500000
3000000
3500000
tryptophan − DAY DAY 3
DOSE_MG_KG
amou
nt 8
8
Mann−Whitney U: : 0.13 (for DOSE_MG_KG )
●
0 60
1500000
2000000
2500000
3000000
3500000
tryptophan − DAY DAY 5
DOSE_MG_KGam
ount
8
8
Mann−Whitney U: : 0.00031 (for DOSE_MG_KG )
0 60
0e+00
1e+06
2e+06
3e+06
4e+06
5e+06
6e+06
7e+06
arginine − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.57 (for DOSE_MG_KG )
●
0 60
0e+00
1e+06
2e+06
3e+06
4e+06
5e+06
6e+06
7e+06
arginine − DAY DAY 3
DOSE_MG_KG
amou
nt 8
8
Mann−Whitney U: : 0.038 (for DOSE_MG_KG )
●
●
0 60
0e+00
1e+06
2e+06
3e+06
4e+06
5e+06
6e+06
7e+06
arginine − DAY DAY 5
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.015 (for DOSE_MG_KG )
●
0 60
1e+05
2e+05
3e+05
4e+05
5e+05
6e+05
7e+05
citrulline − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.015 (for DOSE_MG_KG )
0 60
1e+05
2e+05
3e+05
4e+05
5e+05
6e+05
7e+05
citrulline − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.0019 (for DOSE_MG_KG )
0 60
1e+05
2e+05
3e+05
4e+05
5e+05
6e+05
7e+05
citrulline − DAY DAY 5
DOSE_MG_KGam
ount
8
8
Mann−Whitney U: : 0.00016 *(for DOSE_MG_KG )
0 60
200000
250000
300000
350000
400000
450000
NN.dimethylarginine..ADMA. − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.8 (for DOSE_MG_KG )
●
0 60
200000
250000
300000
350000
400000
450000
NN.dimethylarginine..ADMA. − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.10 (for DOSE_MG_KG )
0 60
200000
250000
300000
350000
400000
450000
NN.dimethylarginine..ADMA. − DAY DAY 5
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.65 (for DOSE_MG_KG )
0 60
1.5e+07
2.0e+07
2.5e+07
3.0e+07
3.5e+07
ornithine − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.010 (for DOSE_MG_KG )
0 60
1.5e+07
2.0e+07
2.5e+07
3.0e+07
3.5e+07
ornithine − DAY DAY 3
DOSE_MG_KG
amou
nt
7
8
Mann−Whitney U: : 0.021 (for DOSE_MG_KG )
●
0 60
1.5e+07
2.0e+07
2.5e+07
3.0e+07
3.5e+07
ornithine − DAY DAY 5
DOSE_MG_KGam
ount
8
8
Mann−Whitney U: : 0.00062 (for DOSE_MG_KG )
0 60
1000000
1500000
2000000
proline − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.8 (for DOSE_MG_KG )
0 60
1000000
1500000
2000000
proline − DAY DAY 3
DOSE_MG_KG
amou
nt 8
8
Mann−Whitney U: : 0.0047 (for DOSE_MG_KG )
●
0 60
1000000
1500000
2000000
proline − DAY DAY 5
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.0030 (for DOSE_MG_KG )
●
●
0 60
2e+05
4e+05
6e+05
8e+05
1e+06
trans.4.hydroxyproline − DAY DAY 2
DOSE_MG_KG
amou
nt
88
Mann−Whitney U: : 0.96 (for DOSE_MG_KG )
0 60
2e+05
4e+05
6e+05
8e+05
1e+06
trans.4.hydroxyproline − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.96 (for DOSE_MG_KG )
0 60
2e+05
4e+05
6e+05
8e+05
1e+06
trans.4.hydroxyproline − DAY DAY 5
DOSE_MG_KGam
ount
8
8
Mann−Whitney U: : 0.0030 (for DOSE_MG_KG )
0 60
1.5e+07
2.0e+07
2.5e+07
3.0e+07
urea − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.57 (for DOSE_MG_KG )
0 60
1.5e+07
2.0e+07
2.5e+07
3.0e+07
urea − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.05 (for DOSE_MG_KG )
0 60
1.5e+07
2.0e+07
2.5e+07
3.0e+07
urea − DAY DAY 5
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.72 (for DOSE_MG_KG )
●
0 60
3e+06
4e+06
5e+06
6e+06
7e+06
8e+06
9e+06
isoleucine − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.33 (for DOSE_MG_KG )
0 60
3e+06
4e+06
5e+06
6e+06
7e+06
8e+06
9e+06
isoleucine − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.0030 (for DOSE_MG_KG )
0 60
3e+06
4e+06
5e+06
6e+06
7e+06
8e+06
9e+06
isoleucine − DAY DAY 5
DOSE_MG_KGam
ount
8
8
Mann−Whitney U: : 0.00031 (for DOSE_MG_KG )
0 60
1.5e+07
2.0e+07
2.5e+07
3.0e+07
3.5e+07
4.0e+07
leucine − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.13 (for DOSE_MG_KG )
0 60
1.5e+07
2.0e+07
2.5e+07
3.0e+07
3.5e+07
4.0e+07
leucine − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.05 (for DOSE_MG_KG )
0 60
1.5e+07
2.0e+07
2.5e+07
3.0e+07
3.5e+07
4.0e+07
leucine − DAY DAY 5
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.0011 (for DOSE_MG_KG )
0 60
20000
30000
40000
50000
N.acetylalanine − DAY DAY 2
DOSE_MG_KG
amou
nt
88
Mann−Whitney U: : 0.88 (for DOSE_MG_KG )
0 60
20000
30000
40000
50000
N.acetylalanine − DAY DAY 3
DOSE_MG_KG
amou
nt
8
7
Mann−Whitney U: : 0.12 (for DOSE_MG_KG )
●
●
●
0 60
20000
30000
40000
50000
N.acetylalanine − DAY DAY 5
DOSE_MG_KGam
ount
8
5
Mann−Whitney U: : 0.13 (for DOSE_MG_KG )
0 60
2e+06
3e+06
4e+06
5e+06
6e+06
valine − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.038 (for DOSE_MG_KG )
0 60
2e+06
3e+06
4e+06
5e+06
6e+06
valine − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.007 (for DOSE_MG_KG )
●
0 60
2e+06
3e+06
4e+06
5e+06
6e+06
valine − DAY DAY 5
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.00062 (for DOSE_MG_KG )
●
0 60
600000
800000
1000000
1200000
1400000
1600000
N.acetylglucosamine − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.021 (for DOSE_MG_KG )
0 60
600000
800000
1000000
1200000
1400000
1600000
N.acetylglucosamine − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.0019 (for DOSE_MG_KG )
0 60
600000
800000
1000000
1200000
1400000
1600000
N.acetylglucosamine − DAY DAY 5
DOSE_MG_KGam
ount
8
8
Mann−Whitney U: : 0.015 (for DOSE_MG_KG )
0 60
2e+05
4e+05
6e+05
8e+05
N.acetylglucosamine.6.phosphate − DAY DAY 2
DOSE_MG_KG
amou
nt
5
8
Mann−Whitney U: : 0.22 (for DOSE_MG_KG )
0 60
2e+05
4e+05
6e+05
8e+05
N.acetylglucosamine.6.phosphate − DAY DAY 3
DOSE_MG_KG
amou
nt
6
7
Mann−Whitney U: : 0.051 (for DOSE_MG_KG )
●
0 60
2e+05
4e+05
6e+05
8e+05
N.acetylglucosamine.6.phosphate − DAY DAY 5
DOSE_MG_KG
amou
nt
6
5
Mann−Whitney U: : 0.66 (for DOSE_MG_KG )
●
●
●
0 60
200000
400000
600000
800000
1000000
1200000
1400000
N.acetylmannosamine − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.038 (for DOSE_MG_KG )
0 60
200000
400000
600000
800000
1000000
1200000
1400000
N.acetylmannosamine − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.015 (for DOSE_MG_KG )
0 60
200000
400000
600000
800000
1000000
1200000
1400000
N.acetylmannosamine − DAY DAY 5
DOSE_MG_KGam
ount
7
8
Mann−Whitney U: : 0.00031 (for DOSE_MG_KG )
0 60
150000
200000
250000
300000
350000
400000
450000
fructose − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.88 (for DOSE_MG_KG )
●
0 60
150000
200000
250000
300000
350000
400000
450000
fructose − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.010 (for DOSE_MG_KG )
0 60
150000
200000
250000
300000
350000
400000
450000
fructose − DAY DAY 5
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.0011 (for DOSE_MG_KG )
●
0 60
1000000
1500000
2000000
2500000
3000000
3500000
galactose.1.phosphate − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.19 (for DOSE_MG_KG )
0 60
1000000
1500000
2000000
2500000
3000000
3500000
galactose.1.phosphate − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.00016 *(for DOSE_MG_KG )
●
0 60
1000000
1500000
2000000
2500000
3000000
3500000
galactose.1.phosphate − DAY DAY 5
DOSE_MG_KGam
ount
8
8
Mann−Whitney U: : 0.00016 *(for DOSE_MG_KG )
●
0 60
0.0e+00
5.0e+07
1.0e+08
1.5e+08
maltose − DAY DAY 2
DOSE_MG_KG
amou
nt
3 8
Mann−Whitney U: : 0.024 (for DOSE_MG_KG )
●
●
●
0 60
0.0e+00
5.0e+07
1.0e+08
1.5e+08
maltose − DAY DAY 3
DOSE_MG_KG
amou
nt
5
7
Mann−Whitney U: : 0.0025 (for DOSE_MG_KG )
0 60
0.0e+00
5.0e+07
1.0e+08
1.5e+08
maltose − DAY DAY 5
DOSE_MG_KG
amou
nt
6
8
Mann−Whitney U: : 0.00067 (for DOSE_MG_KG )
●
0e+00
1e+08
2e+08
3e+08
4e+08
5e+08
maltotriose − DAY DAY 2
DOSE_MG_KG
amou
nt
5
0e+00
1e+08
2e+08
3e+08
4e+08
5e+08
maltotriose − DAY DAY 3
DOSE_MG_KG
amou
nt 8
●
●
0e+00
1e+08
2e+08
3e+08
4e+08
5e+08
maltotriose − DAY DAY 5
DOSE_MG_KGam
ount
7
0 60
2e+07
3e+07
4e+07
5e+07
6e+07
7e+07
8e+07
mannose − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.0011 (for DOSE_MG_KG )
0 60
2e+07
3e+07
4e+07
5e+07
6e+07
7e+07
8e+07
mannose − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.00016 *(for DOSE_MG_KG )
●
0 60
2e+07
3e+07
4e+07
5e+07
6e+07
7e+07
8e+07
mannose − DAY DAY 5
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.00016 *(for DOSE_MG_KG )
0 60
0
500000
1000000
1500000
sorbitol..glucitol. − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.00016 *(for DOSE_MG_KG )
0 60
0
500000
1000000
1500000
sorbitol..glucitol. − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.00016 *(for DOSE_MG_KG )
0 60
0
500000
1000000
1500000
sorbitol..glucitol. − DAY DAY 5
DOSE_MG_KGam
ount
7
8
Mann−Whitney U: : 0.0014 (for DOSE_MG_KG )
●
0 60
150000
200000
250000
300000
350000
400000
X15.anhydroglucitol..15.AG. − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.00062 (for DOSE_MG_KG )
0 60
150000
200000
250000
300000
350000
400000
X15.anhydroglucitol..15.AG. − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.05 (for DOSE_MG_KG )
0 60
150000
200000
250000
300000
350000
400000
X15.anhydroglucitol..15.AG. − DAY DAY 5
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.007 (for DOSE_MG_KG )
0 60
1e+06
2e+06
3e+06
4e+06
5e+06
X3.phosphoglycerate − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.083 (for DOSE_MG_KG )
0 60
1e+06
2e+06
3e+06
4e+06
5e+06
X3.phosphoglycerate − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.038 (for DOSE_MG_KG )
●
0 60
1e+06
2e+06
3e+06
4e+06
5e+06
X3.phosphoglycerate − DAY DAY 5
DOSE_MG_KGam
ount
8
8
Mann−Whitney U: : 0.015 (for DOSE_MG_KG )
●
0 60
1e+08
2e+08
3e+08
4e+08
glucose − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.00016 *(for DOSE_MG_KG )
0 60
1e+08
2e+08
3e+08
4e+08
glucose − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.00016 *(for DOSE_MG_KG )
0 60
1e+08
2e+08
3e+08
4e+08
glucose − DAY DAY 5
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.00016 *(for DOSE_MG_KG )
●
0 60
20000
30000
40000
50000
60000
70000
glycerate − DAY DAY 2
DOSE_MG_KG
amou
nt
8
4
Mann−Whitney U: : 0.0040 (for DOSE_MG_KG )
20000
30000
40000
50000
60000
70000
glycerate − DAY DAY 3
DOSE_MG_KG
amou
nt
8
20000
30000
40000
50000
60000
70000
glycerate − DAY DAY 5
DOSE_MG_KGam
ount
8
●
0 60
5.0e+07
1.0e+08
1.5e+08
lactate − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.028 (for DOSE_MG_KG )
0 60
5.0e+07
1.0e+08
1.5e+08
lactate − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.00016 *(for DOSE_MG_KG )
●
0 60
5.0e+07
1.0e+08
1.5e+08
lactate − DAY DAY 5
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.00016 *(for DOSE_MG_KG )
0 60
400000
600000
800000
1000000
1200000
1400000
1600000
phosphoenolpyruvate..PEP. − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.13 (for DOSE_MG_KG )
0 60
400000
600000
800000
1000000
1200000
1400000
1600000
phosphoenolpyruvate..PEP. − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.007 (for DOSE_MG_KG )
●
0 60
400000
600000
800000
1000000
1200000
1400000
1600000
phosphoenolpyruvate..PEP. − DAY DAY 5
DOSE_MG_KGam
ount
8
8
Mann−Whitney U: : 0.021 (for DOSE_MG_KG )
0 60
400000
600000
800000
1000000
1200000
ribitol..adonitol. − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.23 (for DOSE_MG_KG )
0 60
400000
600000
800000
1000000
1200000
ribitol..adonitol. − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.10 (for DOSE_MG_KG )
0 60
400000
600000
800000
1000000
1200000
ribitol..adonitol. − DAY DAY 5
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.23 (for DOSE_MG_KG )
0 60
4.0e+06
6.0e+06
8.0e+06
1.0e+07
1.2e+07
ribose − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.065 (for DOSE_MG_KG )
0 60
4.0e+06
6.0e+06
8.0e+06
1.0e+07
1.2e+07
ribose − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.010 (for DOSE_MG_KG )
●
0 60
4.0e+06
6.0e+06
8.0e+06
1.0e+07
1.2e+07
ribose − DAY DAY 5
DOSE_MG_KGam
ount
8
8
Mann−Whitney U: : 0.0011 (for DOSE_MG_KG )
●
0 60
800000
1000000
1200000
1400000
1600000
1800000
2000000
xylitol − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.13 (for DOSE_MG_KG )
0 60
800000
1000000
1200000
1400000
1600000
1800000
2000000
xylitol − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.57 (for DOSE_MG_KG )
0 60
800000
1000000
1200000
1400000
1600000
1800000
2000000
xylitol − DAY DAY 5
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.57 (for DOSE_MG_KG )
0 60
8.0e+06
1.0e+07
1.2e+07
1.4e+07
1.6e+07
1.8e+07
ascorbate..Vitamin.C. − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.51 (for DOSE_MG_KG )
0 60
8.0e+06
1.0e+07
1.2e+07
1.4e+07
1.6e+07
1.8e+07
ascorbate..Vitamin.C. − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.65 (for DOSE_MG_KG )
0 60
8.0e+06
1.0e+07
1.2e+07
1.4e+07
1.6e+07
1.8e+07
ascorbate..Vitamin.C. − DAY DAY 5
DOSE_MG_KGam
ount
8
8
Mann−Whitney U: : 0.007 (for DOSE_MG_KG )
0 60
2e+05
4e+05
6e+05
8e+05
1e+06
glucarate..saccharate. − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.10 (for DOSE_MG_KG )
●
0 60
2e+05
4e+05
6e+05
8e+05
1e+06
glucarate..saccharate. − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.88 (for DOSE_MG_KG )
0 60
2e+05
4e+05
6e+05
8e+05
1e+06
glucarate..saccharate. − DAY DAY 5
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.65 (for DOSE_MG_KG )
●
0 60
6.0e+06
8.0e+06
1.0e+07
1.2e+07
1.4e+07
1.6e+07
gulono.14.lactone − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.028 (for DOSE_MG_KG )
0 60
6.0e+06
8.0e+06
1.0e+07
1.2e+07
1.4e+07
1.6e+07
gulono.14.lactone − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.083 (for DOSE_MG_KG )
0 60
6.0e+06
8.0e+06
1.0e+07
1.2e+07
1.4e+07
1.6e+07
gulono.14.lactone − DAY DAY 5
DOSE_MG_KGam
ount
8 8
Mann−Whitney U: : 0.44 (for DOSE_MG_KG )
0 60
1e+05
2e+05
3e+05
4e+05
X5.methyltetrahydrofolate..5MeTHF. − DAY DAY 2
DOSE_MG_KG
amou
nt
8 8
Mann−Whitney U: : 0.8 (for DOSE_MG_KG )
0 60
1e+05
2e+05
3e+05
4e+05
X5.methyltetrahydrofolate..5MeTHF. − DAY DAY 3
DOSE_MG_KG
amou
nt 8
8
Mann−Whitney U: : 0.19 (for DOSE_MG_KG )
0 60
1e+05
2e+05
3e+05
4e+05
X5.methyltetrahydrofolate..5MeTHF. − DAY DAY 5
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.00016 *(for DOSE_MG_KG )
0 60
5000
10000
15000
20000
25000
30000
35000
40000
tetrahydrobiopterin − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.57 (for DOSE_MG_KG )
●
0 60
5000
10000
15000
20000
25000
30000
35000
40000
tetrahydrobiopterin − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 1 (for DOSE_MG_KG )
0 60
5000
10000
15000
20000
25000
30000
35000
40000
tetrahydrobiopterin − DAY DAY 5
DOSE_MG_KGam
ount
8
7
Mann−Whitney U: : 0.029 (for DOSE_MG_KG )
0 60
4e+06
5e+06
6e+06
7e+06
8e+06
9e+06
nicotinamide − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.38 (for DOSE_MG_KG )
0 60
4e+06
5e+06
6e+06
7e+06
8e+06
9e+06
nicotinamide − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.0047 (for DOSE_MG_KG )
●
0 60
4e+06
5e+06
6e+06
7e+06
8e+06
9e+06
nicotinamide − DAY DAY 5
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.028 (for DOSE_MG_KG )
●
0 60
1e+05
2e+05
3e+05
4e+05
5e+05
6e+05
nicotinamide.adenine.dinucleotide..NAD.. − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.065 (for DOSE_MG_KG )
●
0 60
1e+05
2e+05
3e+05
4e+05
5e+05
6e+05
nicotinamide.adenine.dinucleotide..NAD.. − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.00031 (for DOSE_MG_KG )
0 60
1e+05
2e+05
3e+05
4e+05
5e+05
6e+05
nicotinamide.adenine.dinucleotide..NAD.. − DAY DAY 5
DOSE_MG_KGam
ount
8
8
Mann−Whitney U: : 0.0047 (for DOSE_MG_KG )
0 60
20000
40000
60000
80000
100000
120000
140000
nicotinamide.ribonucleotide..NMN. − DAY DAY 2
DOSE_MG_KG
amou
nt
2
8
Mann−Whitney U: : 0.044 (for DOSE_MG_KG )
0 60
20000
40000
60000
80000
100000
120000
140000
nicotinamide.ribonucleotide..NMN. − DAY DAY 3
DOSE_MG_KG
amou
nt
4
8
Mann−Whitney U: : 0.11 (for DOSE_MG_KG )
●
●
0 60
20000
40000
60000
80000
100000
120000
140000
nicotinamide.ribonucleotide..NMN. − DAY DAY 5
DOSE_MG_KG
amou
nt
5
8
Mann−Whitney U: : 0.019 (for DOSE_MG_KG )
0 60
100000
150000
200000
250000
nicotinamide.riboside. − DAY DAY 2
DOSE_MG_KG
amou
nt
88
Mann−Whitney U: : 0.72 (for DOSE_MG_KG )
0 60
100000
150000
200000
250000
nicotinamide.riboside. − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.00031 (for DOSE_MG_KG )
0 60
100000
150000
200000
250000
nicotinamide.riboside. − DAY DAY 5
DOSE_MG_KGam
ount
8
8
Mann−Whitney U: : 0.00016 *(for DOSE_MG_KG )
0 60
50000
100000
150000
200000
250000
300000
trigonelline..N..methylnicotinate. − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.065 (for DOSE_MG_KG )
●
●
0 60
50000
100000
150000
200000
250000
300000
trigonelline..N..methylnicotinate. − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.16 (for DOSE_MG_KG )
0 60
50000
100000
150000
200000
250000
300000
trigonelline..N..methylnicotinate. − DAY DAY 5
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.96 (for DOSE_MG_KG )
0 60
5e+05
6e+05
7e+05
8e+05
9e+05
1e+06
pantothenate − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.38 (for DOSE_MG_KG )
0 60
5e+05
6e+05
7e+05
8e+05
9e+05
1e+06
pantothenate − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.16 (for DOSE_MG_KG )
0 60
5e+05
6e+05
7e+05
8e+05
9e+05
1e+06
pantothenate − DAY DAY 5
DOSE_MG_KGam
ount
8
8
Mann−Whitney U: : 0.065 (for DOSE_MG_KG )
●
0 60
0
500000
1000000
1500000
phosphopantetheine − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.33 (for DOSE_MG_KG )
●
0 60
0
500000
1000000
1500000
phosphopantetheine − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.038 (for DOSE_MG_KG )
0 60
0
500000
1000000
1500000
phosphopantetheine − DAY DAY 5
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.10 (for DOSE_MG_KG )
0 60
15000
20000
25000
30000
pyridoxal − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.065 (for DOSE_MG_KG )
0 60
15000
20000
25000
30000
pyridoxal − DAY DAY 3
DOSE_MG_KG
amou
nt8
8
Mann−Whitney U: : 1 (for DOSE_MG_KG )
0 60
15000
20000
25000
30000
pyridoxal − DAY DAY 5
DOSE_MG_KGam
ount
8 8
Mann−Whitney U: : 0.96 (for DOSE_MG_KG )
0 60
200000
250000
300000
flavin.adenine.dinucleotide..FAD.. − DAY DAY 2
DOSE_MG_KG
amou
nt 8
8
Mann−Whitney U: : 0.8 (for DOSE_MG_KG )
●
0 60
200000
250000
300000
flavin.adenine.dinucleotide..FAD.. − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.16 (for DOSE_MG_KG )
0 60
200000
250000
300000
flavin.adenine.dinucleotide..FAD.. − DAY DAY 5
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.28 (for DOSE_MG_KG )
0 60
300000
350000
400000
450000
500000
550000
600000
riboflavin..Vitamin.B2. − DAY DAY 2
DOSE_MG_KG
amou
nt
88
Mann−Whitney U: : 0.65 (for DOSE_MG_KG )
0 60
300000
350000
400000
450000
500000
550000
600000
riboflavin..Vitamin.B2. − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.57 (for DOSE_MG_KG )
●
0 60
300000
350000
400000
450000
500000
550000
600000
riboflavin..Vitamin.B2. − DAY DAY 5
DOSE_MG_KGam
ount
8 8
Mann−Whitney U: : 0.51 (for DOSE_MG_KG )
●
0 60
200000
400000
600000
800000
1000000
1200000
alpha.tocopherol − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.083 (for DOSE_MG_KG )
0 60
200000
400000
600000
800000
1000000
1200000
alpha.tocopherol − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.13 (for DOSE_MG_KG )
●
●
0 60
200000
400000
600000
800000
1000000
1200000
alpha.tocopherol − DAY DAY 5
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.028 (for DOSE_MG_KG )
●
0 60
20000
40000
60000
80000
pyridoxate − DAY DAY 2
DOSE_MG_KG
amou
nt
7
8
Mann−Whitney U: : 0.46 (for DOSE_MG_KG )
●
0 60
20000
40000
60000
80000
pyridoxate − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.19 (for DOSE_MG_KG )
●
0 60
20000
40000
60000
80000
pyridoxate − DAY DAY 5
DOSE_MG_KGam
ount
8
8
Mann−Whitney U: : 0.23 (for DOSE_MG_KG )
0 60
1e+06
2e+06
3e+06
4e+06
5e+06
fumarate − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.083 (for DOSE_MG_KG )
●
0 60
1e+06
2e+06
3e+06
4e+06
5e+06
fumarate − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.00016 *(for DOSE_MG_KG )
●
●
0 60
1e+06
2e+06
3e+06
4e+06
5e+06
fumarate − DAY DAY 5
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.00031 (for DOSE_MG_KG )
●
0 60
2.0e+06
4.0e+06
6.0e+06
8.0e+06
1.0e+07
1.2e+07
1.4e+07
malate − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.38 (for DOSE_MG_KG )
●
0 60
2.0e+06
4.0e+06
6.0e+06
8.0e+06
1.0e+07
1.2e+07
1.4e+07
malate − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.00016 *(for DOSE_MG_KG )
0 60
2.0e+06
4.0e+06
6.0e+06
8.0e+06
1.0e+07
1.2e+07
1.4e+07
malate − DAY DAY 5
DOSE_MG_KGam
ount
8
8
Mann−Whitney U: : 0.00016 *(for DOSE_MG_KG )
0 60
3e+08
4e+08
5e+08
6e+08
7e+08
8e+08
9e+08
phosphate − DAY DAY 2
DOSE_MG_KG
amou
nt
88
Mann−Whitney U: : 0.72 (for DOSE_MG_KG )
●
●
0 60
3e+08
4e+08
5e+08
6e+08
7e+08
8e+08
9e+08
phosphate − DAY DAY 3
DOSE_MG_KG
amou
nt
87
Mann−Whitney U: : 0.87 (for DOSE_MG_KG )
●
●
0 60
3e+08
4e+08
5e+08
6e+08
7e+08
8e+08
9e+08
phosphate − DAY DAY 5
DOSE_MG_KG
amou
nt
87
Mann−Whitney U: : 0.87 (for DOSE_MG_KG )
0 60
1e+06
2e+06
3e+06
4e+06
5e+06
pyrophosphate..PPi. − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.8 (for DOSE_MG_KG )
●
●
●
0 60
1e+06
2e+06
3e+06
4e+06
5e+06
pyrophosphate..PPi. − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.57 (for DOSE_MG_KG )
0 60
1e+06
2e+06
3e+06
4e+06
5e+06
pyrophosphate..PPi. − DAY DAY 5
DOSE_MG_KGam
ount
8
8
Mann−Whitney U: : 0.8 (for DOSE_MG_KG )
●
●
0 60
0
50000
100000
150000
X6.oxolithocholate − DAY DAY 2
DOSE_MG_KG
amou
nt
76
Mann−Whitney U: : 0.45 (for DOSE_MG_KG )
0 60
0
50000
100000
150000
X6.oxolithocholate − DAY DAY 3
DOSE_MG_KG
amou
nt
76
Mann−Whitney U: : 0.73 (for DOSE_MG_KG )
●
●
0 60
0
50000
100000
150000
X6.oxolithocholate − DAY DAY 5
DOSE_MG_KG
amou
nt
5
7
Mann−Whitney U: : 0.15 (for DOSE_MG_KG )
●
●
0 60
0
500000
1000000
1500000
2000000
2500000
beta.muricholate − DAY DAY 2
DOSE_MG_KG
amou
nt
8 8
Mann−Whitney U: : 0.51 (for DOSE_MG_KG )
0 60
0
500000
1000000
1500000
2000000
2500000
beta.muricholate − DAY DAY 3
DOSE_MG_KG
amou
nt
7
8
Mann−Whitney U: : 0.34 (for DOSE_MG_KG )
●
●
0 60
0
500000
1000000
1500000
2000000
2500000
beta.muricholate − DAY DAY 5
DOSE_MG_KGam
ount
88
Mann−Whitney U: : 0.44 (for DOSE_MG_KG )
0 60
2.0e+06
4.0e+06
6.0e+06
8.0e+06
1.0e+07
1.2e+07
1.4e+07
1.6e+07
chenodeoxycholate − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.0030 (for DOSE_MG_KG )
0 60
2.0e+06
4.0e+06
6.0e+06
8.0e+06
1.0e+07
1.2e+07
1.4e+07
1.6e+07
chenodeoxycholate − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.00062 (for DOSE_MG_KG )
0 60
2.0e+06
4.0e+06
6.0e+06
8.0e+06
1.0e+07
1.2e+07
1.4e+07
1.6e+07
chenodeoxycholate − DAY DAY 5
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.00016 *(for DOSE_MG_KG )
●
●
0 60
0e+00
1e+06
2e+06
3e+06
4e+06
cholate − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.065 (for DOSE_MG_KG )
0 60
0e+00
1e+06
2e+06
3e+06
4e+06
cholate − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.57 (for DOSE_MG_KG )
●
0 60
0e+00
1e+06
2e+06
3e+06
4e+06
cholate − DAY DAY 5
DOSE_MG_KGam
ount
8
8
Mann−Whitney U: : 0.44 (for DOSE_MG_KG )
0
50000
100000
150000
deoxycholate − DAY DAY 2
DOSE_MG_KG
amou
nt
2
0
50000
100000
150000
deoxycholate − DAY DAY 3
DOSE_MG_KG
amou
nt
3
0 60
0
50000
100000
150000
deoxycholate − DAY DAY 5
DOSE_MG_KG
amou
nt
2
3
Mann−Whitney U: : 1 (for DOSE_MG_KG )
0 60
2e+05
4e+05
6e+05
8e+05
1e+06
glycochenodeoxycholate − DAY DAY 2
DOSE_MG_KG
amou
nt
3
5
Mann−Whitney U: : 0.071 (for DOSE_MG_KG )
0 60
2e+05
4e+05
6e+05
8e+05
1e+06
glycochenodeoxycholate − DAY DAY 3
DOSE_MG_KG
amou
nt
5
6
Mann−Whitney U: : 0.54 (for DOSE_MG_KG )
0 60
2e+05
4e+05
6e+05
8e+05
1e+06
glycochenodeoxycholate − DAY DAY 5
DOSE_MG_KGam
ount
3
3
Mann−Whitney U: : 0.4 (for DOSE_MG_KG )
0 60
0e+00
1e+06
2e+06
3e+06
4e+06
5e+06
6e+06
7e+06
glycocholate. − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.010 (for DOSE_MG_KG )
0 60
0e+00
1e+06
2e+06
3e+06
4e+06
5e+06
6e+06
7e+06
glycocholate. − DAY DAY 3
DOSE_MG_KG
amou
nt
8 8
Mann−Whitney U: : 1 (for DOSE_MG_KG )
0 60
0e+00
1e+06
2e+06
3e+06
4e+06
5e+06
6e+06
7e+06
glycocholate. − DAY DAY 5
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.51 (for DOSE_MG_KG )
0 60
0
500000
1000000
1500000
glycodeoxycholate − DAY DAY 2
DOSE_MG_KG
amou
nt
7
6
Mann−Whitney U: : 0.73 (for DOSE_MG_KG )
0 60
0
500000
1000000
1500000
glycodeoxycholate − DAY DAY 3
DOSE_MG_KG
amou
nt
5
4
Mann−Whitney U: : 0.11 (for DOSE_MG_KG )
●
●
0 60
0
500000
1000000
1500000
glycodeoxycholate − DAY DAY 5
DOSE_MG_KGam
ount
6
7
Mann−Whitney U: : 0.63 (for DOSE_MG_KG )
0 60
20000
40000
60000
80000
glycolithocholate − DAY DAY 2
DOSE_MG_KG
amou
nt
7
8
Mann−Whitney U: : 0.094 (for DOSE_MG_KG )
●
0 60
20000
40000
60000
80000
glycolithocholate − DAY DAY 3
DOSE_MG_KG
amou
nt
8
6
Mann−Whitney U: : 0.013 (for DOSE_MG_KG )
0 60
20000
40000
60000
80000
glycolithocholate − DAY DAY 5
DOSE_MG_KG
amou
nt
8
4
Mann−Whitney U: : 0.28 (for DOSE_MG_KG )
●
0 60
0
500000
1000000
1500000
2000000
2500000
3000000
3500000
hyodeoxycholate − DAY DAY 2
DOSE_MG_KG
amou
nt
88
Mann−Whitney U: : 0.96 (for DOSE_MG_KG )
●
0 60
0
500000
1000000
1500000
2000000
2500000
3000000
3500000
hyodeoxycholate − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.44 (for DOSE_MG_KG )
●
●
0 60
0
500000
1000000
1500000
2000000
2500000
3000000
3500000
hyodeoxycholate − DAY DAY 5
DOSE_MG_KGam
ount
8 8
Mann−Whitney U: : 0.65 (for DOSE_MG_KG )
0 60
500000
1000000
1500000
2000000
2500000
3000000
taurochenodeoxycholate − DAY DAY 2
DOSE_MG_KG
amou
nt
58
Mann−Whitney U: : 0.94 (for DOSE_MG_KG )
●
0 60
500000
1000000
1500000
2000000
2500000
3000000
taurochenodeoxycholate − DAY DAY 3
DOSE_MG_KG
amou
nt
4
8
Mann−Whitney U: : 0.46 (for DOSE_MG_KG )
●
0 60
500000
1000000
1500000
2000000
2500000
3000000
taurochenodeoxycholate − DAY DAY 5
DOSE_MG_KG
amou
nt
5 6
Mann−Whitney U: : 0.93 (for DOSE_MG_KG )
●
●
0 60
0
50000
100000
150000
200000
250000
300000
350000
taurocholate − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.028 (for DOSE_MG_KG )
●
0 60
0
50000
100000
150000
200000
250000
300000
350000
taurocholate − DAY DAY 3
DOSE_MG_KG
amou
nt
6
8
Mann−Whitney U: : 0.75 (for DOSE_MG_KG )
0 60
0
50000
100000
150000
200000
250000
300000
350000
taurocholate − DAY DAY 5
DOSE_MG_KGam
ount
7 6
Mann−Whitney U: : 1 (for DOSE_MG_KG )
0 60
0
500000
1000000
1500000
taurodeoxycholic.acid − DAY DAY 2
DOSE_MG_KG
amou
nt
7
4
Mann−Whitney U: : 0.32 (for DOSE_MG_KG )
0 60
0
500000
1000000
1500000
taurodeoxycholic.acid − DAY DAY 3
DOSE_MG_KG
amou
nt
5
2
Mann−Whitney U: : 1 (for DOSE_MG_KG )
●
0 60
0
500000
1000000
1500000
taurodeoxycholic.acid − DAY DAY 5
DOSE_MG_KG
amou
nt
65
Mann−Whitney U: : 1 (for DOSE_MG_KG )
●
0 60
20000
40000
60000
80000
100000
120000
140000
taurolithocholate − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.19 (for DOSE_MG_KG )
●
0 60
20000
40000
60000
80000
100000
120000
140000
taurolithocholate − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.065 (for DOSE_MG_KG )
0 60
20000
40000
60000
80000
100000
120000
140000
taurolithocholate − DAY DAY 5
DOSE_MG_KGam
ount
8 7
Mann−Whitney U: : 0.96 (for DOSE_MG_KG )
●
0 60
20000
40000
60000
80000
100000
120000
ursodeoxycholate − DAY DAY 2
DOSE_MG_KG
amou
nt
1
5
Mann−Whitney U: : 0.67 (for DOSE_MG_KG )
0 60
20000
40000
60000
80000
100000
120000
ursodeoxycholate − DAY DAY 3
DOSE_MG_KG
amou
nt
2
1
Mann−Whitney U: : 0.67 (for DOSE_MG_KG )
0 60
20000
40000
60000
80000
100000
120000
ursodeoxycholate − DAY DAY 5
DOSE_MG_KG
amou
nt
2
1
Mann−Whitney U: : 0.67 (for DOSE_MG_KG )
0 60
1e+05
2e+05
3e+05
4e+05
acetylcarnitine − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.65 (for DOSE_MG_KG )
0 60
1e+05
2e+05
3e+05
4e+05
acetylcarnitine − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.13 (for DOSE_MG_KG )
●
0 60
1e+05
2e+05
3e+05
4e+05
acetylcarnitine − DAY DAY 5
DOSE_MG_KGam
ount
8
8
Mann−Whitney U: : 0.0019 (for DOSE_MG_KG )
●
●
0 60
1000000
1500000
2000000
2500000
3000000
3500000
carnitine − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.33 (for DOSE_MG_KG )
0 60
1000000
1500000
2000000
2500000
3000000
3500000
carnitine − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.015 (for DOSE_MG_KG )
●
0 60
1000000
1500000
2000000
2500000
3000000
3500000
carnitine − DAY DAY 5
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.00062 (for DOSE_MG_KG )
0 60
1e+05
2e+05
3e+05
4e+05
propionylcarnitine − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.38 (for DOSE_MG_KG )
●
0 60
1e+05
2e+05
3e+05
4e+05
propionylcarnitine − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.007 (for DOSE_MG_KG )
0 60
1e+05
2e+05
3e+05
4e+05
propionylcarnitine − DAY DAY 5
DOSE_MG_KGam
ount
8
8
Mann−Whitney U: : 0.0011 (for DOSE_MG_KG )
●
0 60
200000
250000
300000
350000
400000
450000
500000
X12.dipalmitoylglycerol..DAG. − DAY DAY 2
DOSE_MG_KG
amou
nt 7
7
Mann−Whitney U: : 0.097 (for DOSE_MG_KG )
●
0 60
200000
250000
300000
350000
400000
450000
500000
X12.dipalmitoylglycerol..DAG. − DAY DAY 3
DOSE_MG_KG
amou
nt
8
7
Mann−Whitney U: : 0.029 (for DOSE_MG_KG )
0 60
200000
250000
300000
350000
400000
450000
500000
X12.dipalmitoylglycerol..DAG. − DAY DAY 5
DOSE_MG_KG
amou
nt
8
5
Mann−Whitney U: : 0.28 (for DOSE_MG_KG )
0 60
2e+07
3e+07
4e+07
5e+07
6e+07
7e+07
linoleate..18.2.n.6.. − DAY DAY 2
DOSE_MG_KG
amou
nt
8 8
Mann−Whitney U: : 1 (for DOSE_MG_KG )
●
0 60
2e+07
3e+07
4e+07
5e+07
6e+07
7e+07
linoleate..18.2.n.6.. − DAY DAY 3
DOSE_MG_KG
amou
nt8
8
Mann−Whitney U: : 0.010 (for DOSE_MG_KG )
0 60
2e+07
3e+07
4e+07
5e+07
6e+07
7e+07
linoleate..18.2.n.6.. − DAY DAY 5
DOSE_MG_KGam
ount
8
8
Mann−Whitney U: : 0.00016 *(for DOSE_MG_KG )
0 60
1e+06
2e+06
3e+06
4e+06
eicosenoate..9.or.11.cis.or.trans. − DAY DAY 2
DOSE_MG_KG
amou
nt
88
Mann−Whitney U: : 0.96 (for DOSE_MG_KG )
●
0 60
1e+06
2e+06
3e+06
4e+06
eicosenoate..9.or.11.cis.or.trans. − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.19 (for DOSE_MG_KG )
●
●
0 60
1e+06
2e+06
3e+06
4e+06
eicosenoate..9.or.11.cis.or.trans. − DAY DAY 5
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.00031 (for DOSE_MG_KG )
0 60
200000
400000
600000
800000
1000000
1200000
myristoleate..14.1.n.5.. − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.28 (for DOSE_MG_KG )
●
0 60
200000
400000
600000
800000
1000000
1200000
myristoleate..14.1.n.5.. − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.00062 (for DOSE_MG_KG )
●
●
●
0 60
200000
400000
600000
800000
1000000
1200000
myristoleate..14.1.n.5.. − DAY DAY 5
DOSE_MG_KGam
ount
8
8
Mann−Whitney U: : 0.00016 *(for DOSE_MG_KG )
●
●
0 60
2e+07
3e+07
4e+07
5e+07
6e+07
7e+07
oleate.18.1.n.9.. − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.8 (for DOSE_MG_KG )
●
0 60
2e+07
3e+07
4e+07
5e+07
6e+07
7e+07
oleate.18.1.n.9.. − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.028 (for DOSE_MG_KG )
0 60
2e+07
3e+07
4e+07
5e+07
6e+07
7e+07
oleate.18.1.n.9.. − DAY DAY 5
DOSE_MG_KG
amou
nt 8
8
Mann−Whitney U: : 0.00016 *(for DOSE_MG_KG )
0 60
5.0e+06
1.0e+07
1.5e+07
palmitoleate..16.1.n.7.. − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.88 (for DOSE_MG_KG )
0 60
5.0e+06
1.0e+07
1.5e+07
palmitoleate..16.1.n.7.. − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.0047 (for DOSE_MG_KG )
0 60
5.0e+06
1.0e+07
1.5e+07
palmitoleate..16.1.n.7.. − DAY DAY 5
DOSE_MG_KGam
ount
8
8
Mann−Whitney U: : 0.00016 *(for DOSE_MG_KG )
●
0 60
50000
100000
150000
X13c16c.docosadienoate − DAY DAY 2
DOSE_MG_KG
amou
nt
8 8
Mann−Whitney U: : 0.96 (for DOSE_MG_KG )
0 60
50000
100000
150000
X13c16c.docosadienoate − DAY DAY 3
DOSE_MG_KG
amou
nt
88
Mann−Whitney U: : 0.8 (for DOSE_MG_KG )
●
●
0 60
50000
100000
150000
X13c16c.docosadienoate − DAY DAY 5
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.010 (for DOSE_MG_KG )
0 60
5.0e+06
1.0e+07
1.5e+07
2.0e+07
alpha.linolenate..18.3.n.3.. − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.57 (for DOSE_MG_KG )
●
0 60
5.0e+06
1.0e+07
1.5e+07
2.0e+07
alpha.linolenate..18.3.n.3.. − DAY DAY 3
DOSE_MG_KG
amou
nt8
8
Mann−Whitney U: : 0.0019 (for DOSE_MG_KG )
●
●
0 60
5.0e+06
1.0e+07
1.5e+07
2.0e+07
alpha.linolenate..18.3.n.3.. − DAY DAY 5
DOSE_MG_KGam
ount
8
8
Mann−Whitney U: : 0.00016 *(for DOSE_MG_KG )
●
0 60
2.0e+07
2.5e+07
3.0e+07
3.5e+07
4.0e+07
4.5e+07
arachidonate..20.4.n.6.. − DAY DAY 2
DOSE_MG_KG
amou
nt 8
8
Mann−Whitney U: : 0.57 (for DOSE_MG_KG )
0 60
2.0e+07
2.5e+07
3.0e+07
3.5e+07
4.0e+07
4.5e+07
arachidonate..20.4.n.6.. − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.0011 (for DOSE_MG_KG )
●
0 60
2.0e+07
2.5e+07
3.0e+07
3.5e+07
4.0e+07
4.5e+07
arachidonate..20.4.n.6.. − DAY DAY 5
DOSE_MG_KG
amou
nt 8
8
Mann−Whitney U: : 0.0011 (for DOSE_MG_KG )
0 60
1000000
1500000
2000000
dihomo.alpha.linolenate..20.3.n.3.. − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.8 (for DOSE_MG_KG )
0 60
1000000
1500000
2000000
dihomo.alpha.linolenate..20.3.n.3.. − DAY DAY 3
DOSE_MG_KG
amou
nt
88
Mann−Whitney U: : 0.96 (for DOSE_MG_KG )
●
0 60
1000000
1500000
2000000
dihomo.alpha.linolenate..20.3.n.3.. − DAY DAY 5
DOSE_MG_KGam
ount
8
8
Mann−Whitney U: : 0.28 (for DOSE_MG_KG )
0 60
1e+06
2e+06
3e+06
4e+06
5e+06
6e+06
dihomolinolenate..20.2.n.6.. − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.57 (for DOSE_MG_KG )
0 60
1e+06
2e+06
3e+06
4e+06
5e+06
6e+06
dihomolinolenate..20.2.n.6.. − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.028 (for DOSE_MG_KG )
●
0 60
1e+06
2e+06
3e+06
4e+06
5e+06
6e+06
dihomolinolenate..20.2.n.6.. − DAY DAY 5
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.00016 *(for DOSE_MG_KG )
●
●
●
0 60
6.0e+06
8.0e+06
1.0e+07
1.2e+07
1.4e+07
1.6e+07
docosahexaenoate..DHA.22.6.n.3.. − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.72 (for DOSE_MG_KG )
0 60
6.0e+06
8.0e+06
1.0e+07
1.2e+07
1.4e+07
1.6e+07
docosahexaenoate..DHA.22.6.n.3.. − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.021 (for DOSE_MG_KG )
●
0 60
6.0e+06
8.0e+06
1.0e+07
1.2e+07
1.4e+07
1.6e+07
docosahexaenoate..DHA.22.6.n.3.. − DAY DAY 5
DOSE_MG_KGam
ount
8
8
Mann−Whitney U: : 0.010 (for DOSE_MG_KG )
0 60
1e+06
2e+06
3e+06
4e+06
5e+06
6e+06
7e+06
8e+06
n.3.DPA..22.5.n.3.. − DAY DAY 2
DOSE_MG_KG
amou
nt 8
8
Mann−Whitney U: : 0.88 (for DOSE_MG_KG )
●
0 60
1e+06
2e+06
3e+06
4e+06
5e+06
6e+06
7e+06
8e+06
n.3.DPA..22.5.n.3.. − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.00031 (for DOSE_MG_KG )
0 60
1e+06
2e+06
3e+06
4e+06
5e+06
6e+06
7e+06
8e+06
n.3.DPA..22.5.n.3.. − DAY DAY 5
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.00016 *(for DOSE_MG_KG )
0 60
100000
150000
200000
caprate..10.0. − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.13 (for DOSE_MG_KG )
0 60
100000
150000
200000
caprate..10.0. − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.00016 *(for DOSE_MG_KG )
0 60
100000
150000
200000
caprate..10.0. − DAY DAY 5
DOSE_MG_KGam
ount
8
8
Mann−Whitney U: : 0.00016 *(for DOSE_MG_KG )
0 60
20000
30000
40000
50000
60000
70000
80000
90000
caproate..6.0. − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.16 (for DOSE_MG_KG )
●
0 60
20000
30000
40000
50000
60000
70000
80000
90000
caproate..6.0. − DAY DAY 3
DOSE_MG_KG
amou
nt
8
7
Mann−Whitney U: : 0.00031 (for DOSE_MG_KG )
0 60
20000
30000
40000
50000
60000
70000
80000
90000
caproate..6.0. − DAY DAY 5
DOSE_MG_KG
amou
nt
8
6
Mann−Whitney U: : 0.0027 (for DOSE_MG_KG )
●
0 60
20000
30000
40000
50000
60000
caprylate..8.0. − DAY DAY 2
DOSE_MG_KG
amou
nt
8 5
Mann−Whitney U: : 0.66 (for DOSE_MG_KG )
20000
30000
40000
50000
60000
caprylate..8.0. − DAY DAY 3
DOSE_MG_KG
amou
nt
7
●
20000
30000
40000
50000
60000
caprylate..8.0. − DAY DAY 5
DOSE_MG_KGam
ount
6
0 60
400000
600000
800000
1000000
1200000
laurate..12.0. − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.19 (for DOSE_MG_KG )
0 60
400000
600000
800000
1000000
1200000
laurate..12.0. − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.0019 (for DOSE_MG_KG )
0 60
400000
600000
800000
1000000
1200000
laurate..12.0. − DAY DAY 5
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.0030 (for DOSE_MG_KG )
●
0 60
1000000
1500000
2000000
2500000
3000000
myristate..14.0. − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.13 (for DOSE_MG_KG )
●
0 60
1000000
1500000
2000000
2500000
3000000
myristate..14.0. − DAY DAY 3
DOSE_MG_KG
amou
nt8
8
Mann−Whitney U: : 0.0011 (for DOSE_MG_KG )
0 60
1000000
1500000
2000000
2500000
3000000
myristate..14.0. − DAY DAY 5
DOSE_MG_KGam
ount
8
8
Mann−Whitney U: : 0.00016 *(for DOSE_MG_KG )
●
0 60
2.0e+07
2.5e+07
3.0e+07
3.5e+07
4.0e+07
4.5e+07
palmitate..16.0. − DAY DAY 2
DOSE_MG_KG
amou
nt 8
8
Mann−Whitney U: : 0.88 (for DOSE_MG_KG )
0 60
2.0e+07
2.5e+07
3.0e+07
3.5e+07
4.0e+07
4.5e+07
palmitate..16.0. − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.13 (for DOSE_MG_KG )
0 60
2.0e+07
2.5e+07
3.0e+07
3.5e+07
4.0e+07
4.5e+07
palmitate..16.0. − DAY DAY 5
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.00016 *(for DOSE_MG_KG )
●
0 60
2.0e+07
2.5e+07
3.0e+07
3.5e+07
4.0e+07
stearate..18.0. − DAY DAY 2
DOSE_MG_KG
amou
nt
88
Mann−Whitney U: : 0.8 (for DOSE_MG_KG )
●
0 60
2.0e+07
2.5e+07
3.0e+07
3.5e+07
4.0e+07
stearate..18.0. − DAY DAY 3
DOSE_MG_KG
amou
nt
88
Mann−Whitney U: : 0.88 (for DOSE_MG_KG )
0 60
2.0e+07
2.5e+07
3.0e+07
3.5e+07
4.0e+07
stearate..18.0. − DAY DAY 5
DOSE_MG_KGam
ount
8
8
Mann−Whitney U: : 0.083 (for DOSE_MG_KG )
0 60
800000
1000000
1200000
1400000
1600000
margarate..17.0. − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.44 (for DOSE_MG_KG )
●
0 60
800000
1000000
1200000
1400000
1600000
margarate..17.0. − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.23 (for DOSE_MG_KG )
0 60
800000
1000000
1200000
1400000
1600000
margarate..17.0. − DAY DAY 5
DOSE_MG_KG
amou
nt 8
8
Mann−Whitney U: : 0.0030 (for DOSE_MG_KG )
0 60
100000
150000
200000
250000
300000
350000
nonadecanoate..19.0. − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.88 (for DOSE_MG_KG )
●
0 60
100000
150000
200000
250000
300000
350000
nonadecanoate..19.0. − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.8 (for DOSE_MG_KG )
●
0 60
100000
150000
200000
250000
300000
350000
nonadecanoate..19.0. − DAY DAY 5
DOSE_MG_KGam
ount 8
8
Mann−Whitney U: : 0.083 (for DOSE_MG_KG )
0 60
2e+05
3e+05
4e+05
5e+05
6e+05
7e+05
8e+05
pelargonate..9.0. − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.038 (for DOSE_MG_KG )
0 60
2e+05
3e+05
4e+05
5e+05
6e+05
7e+05
8e+05
pelargonate..9.0. − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.00016 *(for DOSE_MG_KG )
0 60
2e+05
3e+05
4e+05
5e+05
6e+05
7e+05
8e+05
pelargonate..9.0. − DAY DAY 5
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.00016 *(for DOSE_MG_KG )
0 60
0e+00
1e+05
2e+05
3e+05
4e+05
5e+05
pentadecanoate..15.0. − DAY DAY 2
DOSE_MG_KG
amou
nt 8
7
Mann−Whitney U: : 0.094 (for DOSE_MG_KG )
●
0 60
0e+00
1e+05
2e+05
3e+05
4e+05
5e+05
pentadecanoate..15.0. − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.19 (for DOSE_MG_KG )
0 60
0e+00
1e+05
2e+05
3e+05
4e+05
5e+05
pentadecanoate..15.0. − DAY DAY 5
DOSE_MG_KGam
ount
8
8
Mann−Whitney U: : 0.00062 (for DOSE_MG_KG )
0 60
30000
40000
50000
60000
70000
80000
90000
undecanoate..11.0. − DAY DAY 2
DOSE_MG_KG
amou
nt 8
8
Mann−Whitney U: : 0.16 (for DOSE_MG_KG )
●
0 60
30000
40000
50000
60000
70000
80000
90000
undecanoate..11.0. − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.021 (for DOSE_MG_KG )
0 60
30000
40000
50000
60000
70000
80000
90000
undecanoate..11.0. − DAY DAY 5
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.00062 (for DOSE_MG_KG )
0 60
2e+05
3e+05
4e+05
5e+05
6e+05
7e+05
choline − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.44 (for DOSE_MG_KG )
●
0 60
2e+05
3e+05
4e+05
5e+05
6e+05
7e+05
choline − DAY DAY 3
DOSE_MG_KG
amou
nt
88
Mann−Whitney U: : 0.57 (for DOSE_MG_KG )
●
0 60
2e+05
3e+05
4e+05
5e+05
6e+05
7e+05
choline − DAY DAY 5
DOSE_MG_KGam
ount
8
8
Mann−Whitney U: : 0.015 (for DOSE_MG_KG )
0 60
2e+07
3e+07
4e+07
5e+07
6e+07
7e+07
glycerol − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.8 (for DOSE_MG_KG )
0 60
2e+07
3e+07
4e+07
5e+07
6e+07
7e+07
glycerol − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.028 (for DOSE_MG_KG )
0 60
2e+07
3e+07
4e+07
5e+07
6e+07
7e+07
glycerol − DAY DAY 5
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.00016 *(for DOSE_MG_KG )
0 60
1e+07
2e+07
3e+07
4e+07
5e+07
glycerol.3.phosphate..G3P. − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.88 (for DOSE_MG_KG )
0 60
1e+07
2e+07
3e+07
4e+07
5e+07
glycerol.3.phosphate..G3P. − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.021 (for DOSE_MG_KG )
0 60
1e+07
2e+07
3e+07
4e+07
5e+07
glycerol.3.phosphate..G3P. − DAY DAY 5
DOSE_MG_KGam
ount
8
8
Mann−Whitney U: : 0.0011 (for DOSE_MG_KG )
●
●
0 60
500000
1000000
1500000
2000000
2500000
3000000
3500000
glycerophosphorylcholine..GPC. − DAY DAY 2
DOSE_MG_KG
amou
nt
88
Mann−Whitney U: : 0.96 (for DOSE_MG_KG )
●
0 60
500000
1000000
1500000
2000000
2500000
3000000
3500000
glycerophosphorylcholine..GPC. − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.13 (for DOSE_MG_KG )
0 60
500000
1000000
1500000
2000000
2500000
3000000
3500000
glycerophosphorylcholine..GPC. − DAY DAY 5
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.0019 (for DOSE_MG_KG )
0 60
2e+06
4e+06
6e+06
8e+06
1e+07
o.phosphoethanolamine − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.0019 (for DOSE_MG_KG )
●
0 60
2e+06
4e+06
6e+06
8e+06
1e+07
o.phosphoethanolamine − DAY DAY 3
DOSE_MG_KG
amou
nt 8
8
Mann−Whitney U: : 0.00016 *(for DOSE_MG_KG )
●
0 60
2e+06
4e+06
6e+06
8e+06
1e+07
o.phosphoethanolamine − DAY DAY 5
DOSE_MG_KGam
ount
8
8
Mann−Whitney U: : 0.00016 *(for DOSE_MG_KG )
0 60
600000
800000
1000000
1200000
1400000
1600000
inositol.1.phosphate..I1P. − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.44 (for DOSE_MG_KG )
0 60
600000
800000
1000000
1200000
1400000
1600000
inositol.1.phosphate..I1P. − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.038 (for DOSE_MG_KG )
0 60
600000
800000
1000000
1200000
1400000
1600000
inositol.1.phosphate..I1P. − DAY DAY 5
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.00016 *(for DOSE_MG_KG )
0 60
1.0e+07
1.5e+07
2.0e+07
2.5e+07
myo.inositol − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.0030 (for DOSE_MG_KG )
●
0 60
1.0e+07
1.5e+07
2.0e+07
2.5e+07
myo.inositol − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.00016 *(for DOSE_MG_KG )
●
0 60
1.0e+07
1.5e+07
2.0e+07
2.5e+07
myo.inositol − DAY DAY 5
DOSE_MG_KGam
ount
8
8
Mann−Whitney U: : 0.00062 (for DOSE_MG_KG )
●
0 60
5.0e+06
1.0e+07
1.5e+07
2.0e+07
X3.hydroxybutyrate..BHBA. − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.028 (for DOSE_MG_KG )
●
0 60
5.0e+06
1.0e+07
1.5e+07
2.0e+07
X3.hydroxybutyrate..BHBA. − DAY DAY 3
DOSE_MG_KG
amou
nt 8
8
Mann−Whitney U: : 0.015 (for DOSE_MG_KG )
0 60
5.0e+06
1.0e+07
1.5e+07
2.0e+07
X3.hydroxybutyrate..BHBA. − DAY DAY 5
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.00016 *(for DOSE_MG_KG )
0 60
50000
100000
150000
200000
250000
300000
X2.linoleoyl.glycerol − DAY DAY 2
DOSE_MG_KG
amou
nt
88
Mann−Whitney U: : 0.8 (for DOSE_MG_KG )
0 60
50000
100000
150000
200000
250000
300000
X2.linoleoyl.glycerol − DAY DAY 3
DOSE_MG_KG
amou
nt
8 8
Mann−Whitney U: : 0.57 (for DOSE_MG_KG )
0 60
50000
100000
150000
200000
250000
300000
X2.linoleoyl.glycerol − DAY DAY 5
DOSE_MG_KGam
ount
8
7
Mann−Whitney U: : 0.0022 (for DOSE_MG_KG )
●
0 60
0e+00
2e+05
4e+05
6e+05
8e+05
linoleoylglycerol..monolinolein. − DAY DAY 2
DOSE_MG_KG
amou
nt
8 8
Mann−Whitney U: : 1 (for DOSE_MG_KG )
0 60
0e+00
2e+05
4e+05
6e+05
8e+05
linoleoylglycerol..monolinolein. − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.028 (for DOSE_MG_KG )
0 60
0e+00
2e+05
4e+05
6e+05
8e+05
linoleoylglycerol..monolinolein. − DAY DAY 5
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.00016 *(for DOSE_MG_KG )
●
●
0 60
400000
600000
800000
1000000
1200000
1400000
stearoylglycerol..monostearin. − DAY DAY 2
DOSE_MG_KG
amou
nt
88
Mann−Whitney U: : 0.72 (for DOSE_MG_KG )
0 60
400000
600000
800000
1000000
1200000
1400000
stearoylglycerol..monostearin. − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.38 (for DOSE_MG_KG )
0 60
400000
600000
800000
1000000
1200000
1400000
stearoylglycerol..monostearin. − DAY DAY 5
DOSE_MG_KGam
ount
8
8
Mann−Whitney U: : 0.038 (for DOSE_MG_KG )
●
●
0 60
50000
100000
150000
200000
250000
sphingosine − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.28 (for DOSE_MG_KG )
0 60
50000
100000
150000
200000
250000
sphingosine − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.10 (for DOSE_MG_KG )
0 60
50000
100000
150000
200000
250000
sphingosine − DAY DAY 5
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.28 (for DOSE_MG_KG )
●
0 60
1e+05
2e+05
3e+05
4e+05
5e+05
6e+05
beta.sitosterol − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.28 (for DOSE_MG_KG )
0 60
1e+05
2e+05
3e+05
4e+05
5e+05
6e+05
beta.sitosterol − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.65 (for DOSE_MG_KG )
●
0 60
1e+05
2e+05
3e+05
4e+05
5e+05
6e+05
beta.sitosterol − DAY DAY 5
DOSE_MG_KGam
ount
8
8
Mann−Whitney U: : 0.19 (for DOSE_MG_KG )
0 60
2e+07
3e+07
4e+07
5e+07
6e+07
cholesterol − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.8 (for DOSE_MG_KG )
●
0 60
2e+07
3e+07
4e+07
5e+07
6e+07
cholesterol − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.65 (for DOSE_MG_KG )
●
0 60
2e+07
3e+07
4e+07
5e+07
6e+07
cholesterol − DAY DAY 5
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.021 (for DOSE_MG_KG )
0 60
2e+05
4e+05
6e+05
8e+05
squalene − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.72 (for DOSE_MG_KG )
0 60
2e+05
4e+05
6e+05
8e+05
squalene − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.0047 (for DOSE_MG_KG )
0 60
2e+05
4e+05
6e+05
8e+05
squalene − DAY DAY 5
DOSE_MG_KGam
ount
7
8
Mann−Whitney U: : 0.00031 (for DOSE_MG_KG )
0 60
2e+04
4e+04
6e+04
8e+04
1e+05
X1.heptadecanoyl.sn.3.phosphocholine − DAY DAY 2
DOSE_MG_KG
amou
nt
1
1
Mann−Whitney U: : 1 (for DOSE_MG_KG )
0 60
2e+04
4e+04
6e+04
8e+04
1e+05
X1.heptadecanoyl.sn.3.phosphocholine − DAY DAY 3
DOSE_MG_KG
amou
nt
1
2
Mann−Whitney U: : 0.67 (for DOSE_MG_KG )
●
●
2e+04
4e+04
6e+04
8e+04
1e+05
X1.heptadecanoyl.sn.3.phosphocholine − DAY DAY 5
DOSE_MG_KG
amou
nt
5
●
●
0 60
50000
100000
150000
200000
250000
300000
X1.Oleoyl.sn.glycero.3.phosphocholine − DAY DAY 2
DOSE_MG_KG
amou
nt
8
7
Mann−Whitney U: : 0.4 (for DOSE_MG_KG )
0 60
50000
100000
150000
200000
250000
300000
X1.Oleoyl.sn.glycero.3.phosphocholine − DAY DAY 3
DOSE_MG_KG
amou
nt
6
7
Mann−Whitney U: : 0.45 (for DOSE_MG_KG )
●
0 60
50000
100000
150000
200000
250000
300000
X1.Oleoyl.sn.glycero.3.phosphocholine − DAY DAY 5
DOSE_MG_KGam
ount
7
8
Mann−Whitney U: : 0.072 (for DOSE_MG_KG )
●
0 60
0
500000
1000000
1500000
2000000
2500000
3000000
3500000
X1.palmitoyl.sn.glycero.3.phosphocholine − DAY DAY 2
DOSE_MG_KG
amou
nt
88
Mann−Whitney U: : 1 (for DOSE_MG_KG )
●
0 60
0
500000
1000000
1500000
2000000
2500000
3000000
3500000
X1.palmitoyl.sn.glycero.3.phosphocholine − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.38 (for DOSE_MG_KG )
0 60
0
500000
1000000
1500000
2000000
2500000
3000000
3500000
X1.palmitoyl.sn.glycero.3.phosphocholine − DAY DAY 5
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.10 (for DOSE_MG_KG )
0 60
1e+06
2e+06
3e+06
4e+06
X1.stearoyl.sn.glycero.3.phosphocholine − DAY DAY 2
DOSE_MG_KG
amou
nt
88
Mann−Whitney U: : 0.8 (for DOSE_MG_KG )
●
0 60
1e+06
2e+06
3e+06
4e+06
X1.stearoyl.sn.glycero.3.phosphocholine − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.065 (for DOSE_MG_KG )
●
0 60
1e+06
2e+06
3e+06
4e+06
X1.stearoyl.sn.glycero.3.phosphocholine − DAY DAY 5
DOSE_MG_KGam
ount
8
8
Mann−Whitney U: : 0.10 (for DOSE_MG_KG )
0 60
2e+04
4e+04
6e+04
8e+04
1e+05
X4.cholesten.7.alpha.ol.3.one − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.015 (for DOSE_MG_KG )
0 60
2e+04
4e+04
6e+04
8e+04
1e+05
X4.cholesten.7.alpha.ol.3.one − DAY DAY 3
DOSE_MG_KG
amou
nt
88
Mann−Whitney U: : 0.65 (for DOSE_MG_KG )
0 60
2e+04
4e+04
6e+04
8e+04
1e+05
X4.cholesten.7.alpha.ol.3.one − DAY DAY 5
DOSE_MG_KG
amou
nt
8 8
Mann−Whitney U: : 0.65 (for DOSE_MG_KG )
0 60
400000
600000
800000
1000000
1200000
1400000
1600000
campesterol − DAY DAY 2
DOSE_MG_KG
amou
nt
8 8
Mann−Whitney U: : 0.8 (for DOSE_MG_KG )
●
0 60
400000
600000
800000
1000000
1200000
1400000
1600000
campesterol − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.10 (for DOSE_MG_KG )
0 60
400000
600000
800000
1000000
1200000
1400000
1600000
campesterol − DAY DAY 5
DOSE_MG_KGam
ount
8 8
Mann−Whitney U: : 0.96 (for DOSE_MG_KG )
●
0 60
2e+05
4e+05
6e+05
8e+05
1e+06
cis.10.heptadecenoate − DAY DAY 2
DOSE_MG_KG
amou
nt
88
Mann−Whitney U: : 0.96 (for DOSE_MG_KG )
0 60
2e+05
4e+05
6e+05
8e+05
1e+06
cis.10.heptadecenoate − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.015 (for DOSE_MG_KG )
0 60
2e+05
4e+05
6e+05
8e+05
1e+06
cis.10.heptadecenoate − DAY DAY 5
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.00016 *(for DOSE_MG_KG )
0 60
0
20000
40000
60000
80000
100000
120000
cis.5.dodecenoate − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.19 (for DOSE_MG_KG )
●
0 60
0
20000
40000
60000
80000
100000
120000
cis.5.dodecenoate − DAY DAY 3
DOSE_MG_KG
amou
nt
8
7
Mann−Whitney U: : 0.0059 (for DOSE_MG_KG )
0 60
0
20000
40000
60000
80000
100000
120000
cis.5.dodecenoate − DAY DAY 5
DOSE_MG_KGam
ount
8
7
Mann−Whitney U: : 0.0093 (for DOSE_MG_KG )
●
0 60
20000
40000
60000
80000
100000
120000
gamma.glutamyltryptophan − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.16 (for DOSE_MG_KG )
0 60
20000
40000
60000
80000
100000
120000
gamma.glutamyltryptophan − DAY DAY 3
DOSE_MG_KG
amou
nt
7
5
Mann−Whitney U: : 1 (for DOSE_MG_KG )
●●
●
0 60
20000
40000
60000
80000
100000
120000
gamma.glutamyltryptophan − DAY DAY 5
DOSE_MG_KG
amou
nt
6
6
Mann−Whitney U: : 0.065 (for DOSE_MG_KG )
0 60
1.0e+07
1.2e+07
1.4e+07
1.6e+07
1.8e+07
2.0e+07
2.2e+07
phenylacetylglycine − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.72 (for DOSE_MG_KG )
●
●
●
0 60
1.0e+07
1.2e+07
1.4e+07
1.6e+07
1.8e+07
2.0e+07
2.2e+07
phenylacetylglycine − DAY DAY 3
DOSE_MG_KG
amou
nt8
8
Mann−Whitney U: : 0.16 (for DOSE_MG_KG )
0 60
1.0e+07
1.2e+07
1.4e+07
1.6e+07
1.8e+07
2.0e+07
2.2e+07
phenylacetylglycine − DAY DAY 5
DOSE_MG_KGam
ount 8
8
Mann−Whitney U: : 0.065 (for DOSE_MG_KG )
0 60
20000
40000
60000
80000
100000
120000
S.methylglutathione − DAY DAY 2
DOSE_MG_KG
amou
nt
78
Mann−Whitney U: : 1 (for DOSE_MG_KG )
●
0 60
20000
40000
60000
80000
100000
120000
S.methylglutathione − DAY DAY 3
DOSE_MG_KG
amou
nt
7
8
Mann−Whitney U: : 0.00062 (for DOSE_MG_KG )
0 60
20000
40000
60000
80000
100000
120000
S.methylglutathione − DAY DAY 5
DOSE_MG_KG
amou
nt
7
8
Mann−Whitney U: : 0.021 (for DOSE_MG_KG )
●
0 60
0
500000
1000000
1500000
2000000
2500000
stearidonate − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.083 (for DOSE_MG_KG )
●
0 60
0
500000
1000000
1500000
2000000
2500000
stearidonate − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.00062 (for DOSE_MG_KG )
●
0 60
0
500000
1000000
1500000
2000000
2500000
stearidonate − DAY DAY 5
DOSE_MG_KGam
ount
8
7
Mann−Whitney U: : 0.00031 (for DOSE_MG_KG )
●
0 60
0e+00
1e+06
2e+06
3e+06
4e+06
tauro.beta.muricholate − DAY DAY 2
DOSE_MG_KG
amou
nt
7 8
Mann−Whitney U: : 0.78 (for DOSE_MG_KG )
●
0 60
0e+00
1e+06
2e+06
3e+06
4e+06
tauro.beta.muricholate − DAY DAY 3
DOSE_MG_KG
amou
nt
7
8
Mann−Whitney U: : 0.96 (for DOSE_MG_KG )
0 60
0e+00
1e+06
2e+06
3e+06
4e+06
tauro.beta.muricholate − DAY DAY 5
DOSE_MG_KG
amou
nt
6
7
Mann−Whitney U: : 0.84 (for DOSE_MG_KG )
0 60
20000
30000
40000
50000
X2..deoxyinosine − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.72 (for DOSE_MG_KG )
0 60
20000
30000
40000
50000
X2..deoxyinosine − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.19 (for DOSE_MG_KG )
0 60
20000
30000
40000
50000
X2..deoxyinosine − DAY DAY 5
DOSE_MG_KGam
ount
8
8
Mann−Whitney U: : 0.88 (for DOSE_MG_KG )
●
0 60
1800000
2000000
2200000
2400000
2600000
2800000
3000000
hypoxanthine − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.23 (for DOSE_MG_KG )
0 60
1800000
2000000
2200000
2400000
2600000
2800000
3000000
hypoxanthine − DAY DAY 3
DOSE_MG_KG
amou
nt
88
Mann−Whitney U: : 0.72 (for DOSE_MG_KG )
0 60
1800000
2000000
2200000
2400000
2600000
2800000
3000000
hypoxanthine − DAY DAY 5
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.51 (for DOSE_MG_KG )
●
●
0 60
1000000
1500000
2000000
2500000
3000000
3500000
inosine − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.33 (for DOSE_MG_KG )
0 60
1000000
1500000
2000000
2500000
3000000
3500000
inosine − DAY DAY 3
DOSE_MG_KG
amou
nt8
8
Mann−Whitney U: : 0.8 (for DOSE_MG_KG )
●
0 60
1000000
1500000
2000000
2500000
3000000
3500000
inosine − DAY DAY 5
DOSE_MG_KGam
ount
8
8
Mann−Whitney U: : 0.10 (for DOSE_MG_KG )
0 60
50000
100000
150000
200000
250000
300000
xanthine − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.38 (for DOSE_MG_KG )
0 60
50000
100000
150000
200000
250000
300000
xanthine − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.23 (for DOSE_MG_KG )
0 60
50000
100000
150000
200000
250000
300000
xanthine − DAY DAY 5
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.00031 (for DOSE_MG_KG )
●
0 60
2000000
2500000
3000000
3500000
4000000
xanthosine − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.8 (for DOSE_MG_KG )
0 60
2000000
2500000
3000000
3500000
4000000
xanthosine − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.0019 (for DOSE_MG_KG )
0 60
2000000
2500000
3000000
3500000
4000000
xanthosine − DAY DAY 5
DOSE_MG_KGam
ount
8
8
Mann−Whitney U: : 0.0011 (for DOSE_MG_KG )
0 60
60000
80000
100000
120000
140000
160000
180000
adenine − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 1 (for DOSE_MG_KG )
0 60
60000
80000
100000
120000
140000
160000
180000
adenine − DAY DAY 3
DOSE_MG_KG
amou
nt
8
6
Mann−Whitney U: : 0.41 (for DOSE_MG_KG )
0 60
60000
80000
100000
120000
140000
160000
180000
adenine − DAY DAY 5
DOSE_MG_KG
amou
nt
7
7
Mann−Whitney U: : 0.46 (for DOSE_MG_KG )
0 60
40000
60000
80000
100000
120000
140000
160000
180000
adenosine − DAY DAY 2
DOSE_MG_KG
amou
nt
8 7
Mann−Whitney U: : 0.7 (for DOSE_MG_KG )
0 60
40000
60000
80000
100000
120000
140000
160000
180000
adenosine − DAY DAY 3
DOSE_MG_KG
amou
nt
78
Mann−Whitney U: : 0.61 (for DOSE_MG_KG )
0 60
40000
60000
80000
100000
120000
140000
160000
180000
adenosine − DAY DAY 5
DOSE_MG_KGam
ount
8
8
Mann−Whitney U: : 0.51 (for DOSE_MG_KG )
0 60
15000
20000
25000
30000
35000
40000
adenosine.5..diphosphate..ADP. − DAY DAY 2
DOSE_MG_KG
amou
nt 87
Mann−Whitney U: : 0.54 (for DOSE_MG_KG )
●
0 60
15000
20000
25000
30000
35000
40000
adenosine.5..diphosphate..ADP. − DAY DAY 3
DOSE_MG_KG
amou
nt
8
5
Mann−Whitney U: : 0.030 (for DOSE_MG_KG )
0 60
15000
20000
25000
30000
35000
40000
adenosine.5..diphosphate..ADP. − DAY DAY 5
DOSE_MG_KG
amou
nt
8
7
Mann−Whitney U: : 0.7 (for DOSE_MG_KG )
0 60
60000
70000
80000
90000
100000
110000
120000
130000
adenosine.5..monophosphate..AMP. − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.33 (for DOSE_MG_KG )
0 60
60000
70000
80000
90000
100000
110000
120000
130000
adenosine.5..monophosphate..AMP. − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.44 (for DOSE_MG_KG )
●
0 60
60000
70000
80000
90000
100000
110000
120000
130000
adenosine.5..monophosphate..AMP. − DAY DAY 5
DOSE_MG_KGam
ount
8
8
Mann−Whitney U: : 0.083 (for DOSE_MG_KG )
●
0 60
6000
8000
10000
12000
14000
X2..deoxyguanosine − DAY DAY 2
DOSE_MG_KG
amou
nt
6
2
Mann−Whitney U: : 0.14 (for DOSE_MG_KG )
0 60
6000
8000
10000
12000
14000
X2..deoxyguanosine − DAY DAY 3
DOSE_MG_KG
amou
nt
4
3
Mann−Whitney U: : 0.4 (for DOSE_MG_KG )
●
0 60
6000
8000
10000
12000
14000
X2..deoxyguanosine − DAY DAY 5
DOSE_MG_KG
amou
nt
7
5
Mann−Whitney U: : 0.34 (for DOSE_MG_KG )
●
0 60
50000
100000
150000
guanosine.5...monophosphate..GMP. − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.88 (for DOSE_MG_KG )
0 60
50000
100000
150000
guanosine.5...monophosphate..GMP. − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.57 (for DOSE_MG_KG )
0 60
50000
100000
150000
guanosine.5...monophosphate..GMP. − DAY DAY 5
DOSE_MG_KGam
ount
8
8
Mann−Whitney U: : 0.38 (for DOSE_MG_KG )
●
0 60
800000
1000000
1200000
1400000
1600000
1800000
2000000
2200000
allantoin − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.72 (for DOSE_MG_KG )
0 60
800000
1000000
1200000
1400000
1600000
1800000
2000000
2200000
allantoin − DAY DAY 3
DOSE_MG_KG
amou
nt 8
8
Mann−Whitney U: : 0.65 (for DOSE_MG_KG )
0 60
800000
1000000
1200000
1400000
1600000
1800000
2000000
2200000
allantoin − DAY DAY 5
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.28 (for DOSE_MG_KG )
0 60
500000
1000000
1500000
2000000
urate − DAY DAY 2
DOSE_MG_KG
amou
nt
88
Mann−Whitney U: : 0.96 (for DOSE_MG_KG )
●
0 60
500000
1000000
1500000
2000000
urate − DAY DAY 3
DOSE_MG_KG
amou
nt8
8
Mann−Whitney U: : 0.015 (for DOSE_MG_KG )
0 60
500000
1000000
1500000
2000000
urate − DAY DAY 5
DOSE_MG_KGam
ount
8
8
Mann−Whitney U: : 0.021 (for DOSE_MG_KG )
0 60
30000
40000
50000
60000
70000
80000
X2..deoxycytidine − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.065 (for DOSE_MG_KG )
0 60
30000
40000
50000
60000
70000
80000
X2..deoxycytidine − DAY DAY 3
DOSE_MG_KG
amou
nt 8
8
Mann−Whitney U: : 0.083 (for DOSE_MG_KG )
0 60
30000
40000
50000
60000
70000
80000
X2..deoxycytidine − DAY DAY 5
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.00016 *(for DOSE_MG_KG )
0 60
5e+05
6e+05
7e+05
8e+05
cytidine − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.13 (for DOSE_MG_KG )
0 60
5e+05
6e+05
7e+05
8e+05
cytidine − DAY DAY 3
DOSE_MG_KG
amou
nt
8 8
Mann−Whitney U: : 0.8 (for DOSE_MG_KG )
0 60
5e+05
6e+05
7e+05
8e+05
cytidine − DAY DAY 5
DOSE_MG_KGam
ount
8
8
Mann−Whitney U: : 1 (for DOSE_MG_KG )
0 60
50000
100000
150000
cytosine − DAY DAY 2
DOSE_MG_KG
amou
nt
7 7
Mann−Whitney U: : 0.62 (for DOSE_MG_KG )
●
●
0 60
50000
100000
150000
cytosine − DAY DAY 3
DOSE_MG_KG
amou
nt
85
Mann−Whitney U: : 0.62 (for DOSE_MG_KG )
●
0 60
50000
100000
150000
cytosine − DAY DAY 5
DOSE_MG_KG
amou
nt
6
7
Mann−Whitney U: : 0.23 (for DOSE_MG_KG )
0 60
40000
60000
80000
100000
120000
140000
orotate − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.33 (for DOSE_MG_KG )
0 60
40000
60000
80000
100000
120000
140000
orotate − DAY DAY 3
DOSE_MG_KG
amou
nt8
3
Mann−Whitney U: : 0.38 (for DOSE_MG_KG )
●
40000
60000
80000
100000
120000
140000
orotate − DAY DAY 5
DOSE_MG_KGam
ount
8
0 60
100000
150000
200000
250000
thymine − DAY DAY 2
DOSE_MG_KG
amou
nt
8
7
Mann−Whitney U: : 0.54 (for DOSE_MG_KG )
●
0 60
100000
150000
200000
250000
thymine − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.16 (for DOSE_MG_KG )
0 60
100000
150000
200000
250000
thymine − DAY DAY 5
DOSE_MG_KG
amou
nt
8 8
Mann−Whitney U: : 0.8 (for DOSE_MG_KG )
●
●
0 60
10000
15000
20000
25000
30000
35000
pseudouridine − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.72 (for DOSE_MG_KG )
0 60
10000
15000
20000
25000
30000
35000
pseudouridine − DAY DAY 3
DOSE_MG_KG
amou
nt8
8
Mann−Whitney U: : 0.44 (for DOSE_MG_KG )
0 60
10000
15000
20000
25000
30000
35000
pseudouridine − DAY DAY 5
DOSE_MG_KGam
ount
8
8
Mann−Whitney U: : 0.33 (for DOSE_MG_KG )
0 60
60000
80000
100000
120000
140000
160000
uracil − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.19 (for DOSE_MG_KG )
0 60
60000
80000
100000
120000
140000
160000
uracil − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.23 (for DOSE_MG_KG )
0 60
60000
80000
100000
120000
140000
160000
uracil − DAY DAY 5
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.015 (for DOSE_MG_KG )
●
0 60
1000000
1500000
2000000
uridine − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.065 (for DOSE_MG_KG )
0 60
1000000
1500000
2000000
uridine − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.38 (for DOSE_MG_KG )
●
0 60
1000000
1500000
2000000
uridine − DAY DAY 5
DOSE_MG_KGam
ount
8
8
Mann−Whitney U: : 0.10 (for DOSE_MG_KG )
●
0 60
20000
30000
40000
50000
60000
gamma.glutamylglutamate − DAY DAY 2
DOSE_MG_KG
amou
nt
6
4
Mann−Whitney U: : 0.61 (for DOSE_MG_KG )
20000
30000
40000
50000
60000
gamma.glutamylglutamate − DAY DAY 3
DOSE_MG_KG
amou
nt
6
20000
30000
40000
50000
60000
gamma.glutamylglutamate − DAY DAY 5
DOSE_MG_KG
amou
nt
6
●
●
0 60
100000
150000
200000
250000
glycylglycine − DAY DAY 2
DOSE_MG_KG
amou
nt
8 8
Mann−Whitney U: : 0.96 (for DOSE_MG_KG )
0 60
100000
150000
200000
250000
glycylglycine − DAY DAY 3
DOSE_MG_KG
amou
nt
88
Mann−Whitney U: : 0.8 (for DOSE_MG_KG )
0 60
100000
150000
200000
250000
glycylglycine − DAY DAY 5
DOSE_MG_KGam
ount
8
8
Mann−Whitney U: : 0.010 (for DOSE_MG_KG )
0 60
4e+04
6e+04
8e+04
1e+05
glycylproline − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.33 (for DOSE_MG_KG )
0 60
4e+04
6e+04
8e+04
1e+05
glycylproline − DAY DAY 3
DOSE_MG_KG
amou
nt
88
Mann−Whitney U: : 0.57 (for DOSE_MG_KG )
●
●
0 60
4e+04
6e+04
8e+04
1e+05
glycylproline − DAY DAY 5
DOSE_MG_KG
amou
nt
8
7
Mann−Whitney U: : 0.19 (for DOSE_MG_KG )
0 60
20000
40000
60000
80000
100000
120000
glycylvaline − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.16 (for DOSE_MG_KG )
0 60
20000
40000
60000
80000
100000
120000
glycylvaline − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.72 (for DOSE_MG_KG )
0 60
20000
40000
60000
80000
100000
120000
glycylvaline − DAY DAY 5
DOSE_MG_KGam
ount
8
7
Mann−Whitney U: : 0.12 (for DOSE_MG_KG )
0 60
50000
100000
150000
200000
gamma.glutamylleucine − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.65 (for DOSE_MG_KG )
0 60
50000
100000
150000
200000
gamma.glutamylleucine − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.0030 (for DOSE_MG_KG )
0 60
50000
100000
150000
200000
gamma.glutamylleucine − DAY DAY 5
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.0011 (for DOSE_MG_KG )
●
0 60
20000
25000
30000
35000
40000
gammaglutamylphenylalanine − DAY DAY 2
DOSE_MG_KG
amou
nt
5
4
Mann−Whitney U: : 0.56 (for DOSE_MG_KG )
0 60
20000
25000
30000
35000
40000
gammaglutamylphenylalanine − DAY DAY 3
DOSE_MG_KG
amou
nt
6
3
Mann−Whitney U: : 0.9 (for DOSE_MG_KG )
0 60
20000
25000
30000
35000
40000
gammaglutamylphenylalanine − DAY DAY 5
DOSE_MG_KGam
ount
6
1
Mann−Whitney U: : 0.57 (for DOSE_MG_KG )
0 60
10000
20000
30000
40000
50000
hippurate − DAY DAY 2
DOSE_MG_KG
amou
nt
88
Mann−Whitney U: : 0.65 (for DOSE_MG_KG )
0 60
10000
20000
30000
40000
50000
hippurate − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.028 (for DOSE_MG_KG )
0 60
10000
20000
30000
40000
50000
hippurate − DAY DAY 5
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.00016 *(for DOSE_MG_KG )
●
0 60
3e+05
4e+05
5e+05
6e+05
glycerol.2.phosphate − DAY DAY 2
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.51 (for DOSE_MG_KG )
0 60
3e+05
4e+05
5e+05
6e+05
glycerol.2.phosphate − DAY DAY 3
DOSE_MG_KG
amou
nt
8
8
Mann−Whitney U: : 0.28 (for DOSE_MG_KG )
0 60
3e+05
4e+05
5e+05
6e+05
glycerol.2.phosphate − DAY DAY 5
DOSE_MG_KGam
ount
8
8
Mann−Whitney U: : 0.44 (for DOSE_MG_KG )
50000
100000
150000
F.045.30. − DAY DAY 2
DOSE_MG_KG
amou
nt
1
●
●
50000
100000
150000
F.045.30. − DAY DAY 3
DOSE_MG_KG
amou
nt
5
50000
100000
150000
F.045.30. − DAY DAY 5
DOSE_MG_KG
amou
nt
7
500000
1000000
1500000
F.047.25. − DAY DAY 2
DOSE_MG_KG
amou
nt
8
500000
1000000
1500000
F.047.25. − DAY DAY 3
DOSE_MG_KG
amou
nt
8
500000
1000000
1500000
F.047.25. − DAY DAY 5
DOSE_MG_KGam
ount
8
