Malaria Dept. of Infectious Disease Shengjing Hospital CMU.

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<ul><li> Slide 1 </li> <li> Malaria Dept. of Infectious Disease Shengjing Hospital CMU </li> <li> Slide 2 </li> <li> Definition Definition Malaria is a parasitosis caused by plasmodia. It is transmitted to human by the mosquito. Clinical feature: cyclic chill, high fever &amp; profuse sweating. In chronic illness, there are anemia &amp; splenomegaly. </li> <li> Slide 3 </li> <li> Etiology Etiology Causative organism: Plasmodia P. Vivax: tertian malaria P. Malariae: quartan malaria P. Falciparum: malignant malaria P. Ovale: tertian malaria Pathogenicity: merozoite, malarial pigment &amp; products of metabolism </li> <li> Slide 4 </li> <li> Etiology Etiology Tachysporozoite Bradysporozoite Merozoite Sporozoite Parasitemia </li> <li> Slide 5 </li> <li> Etiology Etiology Two periods: human - whole asexual reproduction mosquito - sexual parasitic stage Two hosts: human - intermediate host mosquito - final host notes: clinical symptoms: erythrocytic stage relapse: exerythrocytic stage infectivity: sporozoite </li> <li> Slide 6 </li> <li> Life cycle of the malaria parasite mosquito microgametocyte zygote oocyst sporozoite Blood stream tachysporozoite merozoite maturerupture Bradysporozoite Blood stream reenter phagocyte merozoite trophzoite shizont mature release merozoite gametocyte Erythrocytic phase Exoerythrocytic stage human </li> <li> Slide 7 </li> <li> Slide 8 </li> <li> Slide 9 </li> <li> Slide 10 </li> <li> Epidemiology Source of infection Patient, parasite carrier Route of transmission female mosquito biting person blood transfusion Susceptibility: universal susceptibility no-cross-immunity re-infection Epidemic features: sporadic or endemic, tropic or subtropic </li> <li> Slide 11 </li> <li> Pathogenesis Pathogenesis Mechanism of attack merozoite RBC rupture malaria pigment products of metabolism blood stream allergy P. Faciparam: produce microvascular disease magnitude of the parasitemia &amp; age of patient no specific Ab or cell -mediated response </li> <li> Slide 12 </li> <li> Pathology Pathology Anemia: P. Vivax - retiform RBC P. Malariae - mature RBC P. Falciparum - every RBC Prolifeation of mononuclear phagocyte hepatomegaly splenomegaly Cerebral edema &amp; congestion </li> <li> Slide 13 </li> <li> Clinical manifestation Clinical manifestation Incubation period: quartan malaria: 24-30 day tertian malaria: 13~15 day malignant malaria: 7~12 day </li> <li> Slide 14 </li> <li> Clinical manifestation Typical attack Chill: abrupt onset, shivering, pale face,cyanosis. Last 10 min or 1~2hr. High fever: T rise to 40 o C with malaise, myalgia, thirsty. Last 2~6 hr. Sweating: profuse sweating with restlessness regular 48 hr. or 72 hr. Cycle </li> <li> Slide 15 </li> <li> Clinical manifestation Sings anemia splenomegaly hepatomegaly, ALT elevate </li> <li> Slide 16 </li> <li> Clinical manifestation Pernicious attack: caused by P. Falciparum cerebral malaria high fever, headache, vomiting, convulsion delirium, respiratory failure hyperpyrexia type T&gt; 42 0 C, convulsion, delirium Relapse: early relapse - 6m </li> <li> Slide 17 </li> <li> Clinical manifestation Malaria caused by transfusion incubation period: 7~10 day no exoerythrogenic phase, no relapse </li> <li> Slide 18 </li> <li> Complications Complications Black- water- fever: cause: 1/inadequate G-6-PD 2/The toxin release by malarial parasite 3/Allergic reaction to anti-malarial drugs feature:1/chill &amp; fever 2/dark red or black urine 3/severe hemolytic anemia Acute glomerulonephritis </li> <li> Slide 19 </li> <li> Laboratory Findings Laboratory Findings Blood picture: decrease in RBC &amp; Hb blood film for parasite serological examination ELISA for P. antigen DNA hybridization </li> <li> Slide 20 </li> <li> Diagnosis Diagnosis Epidemiological data endemic zone blood transfusion Clinical manifestation Laboratory findings Diagnostic treatment: chloroqunine for 3 days </li> <li> Slide 21 </li> <li> Differential Diagnosis Differential Diagnosis Typhoid fever Septicemia Leptospirosis Encephalitis B </li> <li> Slide 22 </li> <li> Treatment Treatment Anti-malarial drugs Chloroquine-susceptable infection chloroquine : 1g /d, for 3 day, p.o. primaquine: for 8day, p.o. Chloroquine-resistant infection mefloguine: artemisinine </li> <li> Slide 23 </li> <li> Treatment Treatment Pernicious attack Chloroquine: 10mg/kg iv drop in 4 hr. Then 5mg/kg, iv drop in 2 hr. Quinine: 500mg iv drop in 4 hr. Radical therapy Chloroquine (3 day) + primaquine ( 8 day ) </li> <li> Slide 24 </li> <li> Prevention Prevention Drug prophylaxis chloroquine: 0.3g once a week doxycycline Kill mosquito Vaccination </li> </ul>


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