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MalariaBy: Anish Jaisinghani
Date: 11-10-2014
Period: 3rd
Definition and cause
Local mosquitos bite nearby people in the endemic area that carry malaria and then transmit it to other locals. Malaria starts in the stomach of the mosquito, and it then releases sporozoites which make their way into the mosquito’s saliva, and the mosquito bites a person, starting the process in people. It will mainly affect liver cells. After the initial liver infection, the infected cells undergo asexual reproduction. This causes the malaria to spread throughout the body, causing many problems.
In the USA two main species transmitted malaria: Anopheles quadrimaculatus & freeborni
Symptoms
Frequently reported symptoms:
o Attacks: lasts 6-10 hours.
• First stage: cold.
• Second stage: hot.
• Third stage: sweating.
o Symptoms: fever, sweats, nausea, chills, headaches, body aches, faster breathing
Data points/Statistics
Around 3.4 billion people are at risk of malaria each year
In 2012, 207 million people reported cases of malaria, and 627000 people died
In 2012 90% of the world’s malaria deaths occurred in Africa
Places in world with malaria transmission:
Body Systems Affected
Malaria mainly affects the liver
If malaria starts growing in the liver, it can cause relapses months or even years later
Eventually they might infect red blood cells
It grows in a very long life cycle as shown in the next slide
Prognosis
When a person is infected, there will be an incubation period that lasts 7 days to 30 days
As the disease progresses it goes from uncomplicated malaria to severe malaria
o Severe malaria causes organ failures. It causes malaria to spread throughout the body, infecting many organs.
• Symptoms: abnormal behavior, unconsciousness, seizures, coma, destruction of red blood cells, hemoglobinuria, breathing issues, blood coagulation issues, cardiovascular collapse, kidney failure, excessive acidity in blood and tissue fluids, low blood glucose
Cure
The treatment depends on many factors
In areas without chloroquine-resistant strains, a person can be treated with an oral chloroquine.
In areas with the strain, there are four options: Malarone, Coartem if they are not pregnant or pediatric. Quinine sulfate plus « doxycycline, tetracycline, or clindamycin » is the 3rd option. Quinine plus doxycycline or tetracycline had more desired results. The fourth option, mefloquine, is the last resort.
Drugs can be taken by travelers to delay the appearance of symptoms by weeks or months
Climate
The growth cycle of malaria in mosquitos cannot be completed at temperatures below 20ºC (68ºF) and it cannot be transmitted
In countries with malaria, transmission doesn’t occur at high altitudes, cold seasons, and deserts
Transmission is more intense in warm, tropical regions
Interesting Facts
The USA has a chloroquine-resistant strain so we only have 4 cures to chose from.
Malaria in Africa is extremely hard to control. There are many reasons: perfect climate, unawareness, no immunity to disease, and high costs for cure
CDC collaborates with Ministries of Health to fight malaria
Climate is one of the biggest factors in the transmission of malaria
CDC contributes to research of malaria on USA citizens
Visit this link for a story about a person with malaria: http://www.cdc.gov/malaria/stories/morethanjetlag.html
Citation
http://www.cdc.gov/malaria/about/facts.html
http://www.cdc.gov/malaria/about/disease.html
http://www.cdc.gov/malaria/about/distribution.html
http://www.who.int/features/factfiles/malaria/en/#
http://www.who.int/features/factfiles/malaria/malaria_facts/en/index2.html
http://data.unicef.org/child-health/malaria
http://www.cdc.gov/malaria/about/biology/index.html
http://www.cdc.gov/malaria/malaria_worldwide/index.html
http://www.cdc.gov/malaria/stories/morethanjetlag.html