Machine Learning& Bioinformatics

Machine Learning & Bioinformatics 1

Tien-Hao Chang (Darby Chang)

PPI Prediction

Machine Learning & Bioinformatics 2

Shen et al. 2007, PNAS

Yu et al. 2010, BMC Bioinformatics

Any drawbacks

Machine Learning & Bioinformatics 5

using conjoint triads?

Drawbacks of conjoint triads From biology

– consider only “local” features (Guo et al. 2008)

– involve non-interface features (Chang et al. 2010)

From engineering– frequency bias (Yu et al. 2010)

– infeasible time/space complexity (submitted)

Machine Learning & Bioinformatics 6

Solving the drawbacks From biology

– consider only “local” features engineering

– involve non-interface features biology

From engineering– frequency bias engineering

– infeasible time/space complexity biology

Machine Learning & Bioinformatics 7

Guo et al. 2008, Nucleic Acids Research

Chang et al. 2010, BMC Bioinformatics

Chang et al. 2010, BMC Bioinformatics

Yu et al. 2010, BMC Bioinformatics

Again

Machine Learning & Bioinformatics 12

any drawbacks/ideas now?