M. Pharmacy I –Sem. (CBCS) (Common to all) (Backlog ...gprcp.ac.in/Qpmp/2016/all cology 1 all.pdf · 1. a) Define bioassay and describe in detail about types of bioassay. (9) b)

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Code No: 13110/CBCS

FACULTY OF PHARMACYM. Pharmacy I –Sem. (CBCS) (Common to all) (Backlog) Examination, August 2019

Subject: Pharmaceutical Analytical TechniquesTime: 3 Hours Max.Marks:75

Note: Answer any five questions. All questions carry equal marks

1. (a) Explain the concept of chromophore and auxo-chrome with examples. 6(b) Describe different quantitative methods used for quantitative analysis of multi

component samples. 9

2. (a) Give the principle and theory involved in FTIR spectroscopy. 7(b) Explain different sample handling techniques for IR spectroscopy. 8

3. Write about the following 3x5=15(a) Shielding and de shielding(b) Chemical shift(c) Spin-Spin coupling

4. (a) Describe the Principle and working of Mass spectrometer with a neat labeleddiagram. 9

(b) Explain about different fragmentation rules and patterns with respect to variousfunctional groups. 6

5. Write about the following 2 x 7 ½ = 15(a) Derivatisation techniques in GC(b) Chiral chromatography

6. (a) Explain the principle and procedure involved in a radioimmunoassay with anexample. 8

(b) Describe capillary electrophoresis technique along with separation principles. 7

7. (a) Discuss the principles of DTA and DSC techniques. 8(b) Explain the thermo gram of polymers. 7

8. (a) Give the principles of X-Ray diffraction methods. 4(b) Explain Bragg’s equation and Miller indices. 5(c) Describe rotating crystal technique for X-ray diffraction studies. 6

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Code No. 13122 / CBCSFACULTY OF PHARMACY

M. Pharmacy (Pharmacology) I – Semester (CBCS) (Backlog) Examination, Aug. 2019Subject: Molecular Pharmacology and Drug Design

Time: 3 Hours Max.Marks: 75Note: Answer any five questions. All questions carry equal marks.

1 a) Explain in brief about G-Protein coupled receptors. 9

b) Write a note on biosensors. 6

2 a) Describe about neurosteroids and neuropeptides. 10

b) Write a note on nitric oxide. 5

3 a) Classify adrenergic receptors .Explain their physiological role. 2+8

b) Describe in brief about GABA receptors. 5

4 a) Explain any four herbal antidiabetic drugs. 10

b) Write a note on reverse pharmacognosy. 5

5 a) Explain in brief about CADD. 7

b) Write note on reporter gene assay and solid phase synthesis. 4+4

6 a) Describe the pathways of apoptosis. 8

b) Explain in brief about cox-2 regulators. 7

7 a) Write a note on histamine receptors and their modulators. 4+4

b) Write in brief about herbal anticancer agents. 7

8 Write a note on following: 3x5 3 a) Prodrug.

b) Third messengers.

c) Ion Channels.****


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M. Pharmacy (Pharmacology) I – Semester (CBCS) (Backlog) Examination, Aug. 2019Subject: Principles of Toxicology

Time: 3 Hours Max.Marks: 75Note: Answer any five questions. All questions carry equal marks.

1. Write a detailed note on determination of MTD, LD50 as per OECD-425 guidelines. 15

2. Explain the USFDA or OECD guidelines for the assessment of new drug safety. 15

3. Write short notes on the following:

a) Allergenicity testing 7½

b) Reproductive toxicity testing 7½

4. Discuss the following in detail:

a) Lead poisoning 7½ 7

b) Opium poisoning 7½7

5. Discuss the risk-benefit asssessment and management in pharmacovigilance. 15

6. Explain the ICH guidelines for the assessment of new drug safety. 15

7. Explain various studies for mutagenicity testing. 15

8. Discuss the following in detail:

a) Serious Adverse Events (SAE) 7½

b) Serious Adverse Reaction (SAR). 7½

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Code No. 13119/CBCSFACULTY OF PHARMACY

M. Pharmacy (Pharmacology) I-Semester (CBCS)(Backlog) Examination,Aug. 2019

Subject: Advanced Pharmacology

Time: 3 Hours Max. Marks: 75Note: Answer any five questions. All questions carry equal marks.

1. Write about various types of receptors, their interactions with drugs leading to

pharmacological activity suitable examples. (15 M)

2. a) Explain the role of free vadicals in etio pathology of various diseases. (9 M)

b) Write a note on immune modulators. (6M)

3. Write short notes on (8+7M)

(a) -Adrenergic blockers

(b) Anticholinesterases

4. Classify various types of seizures in epilepsy. Give the classification of antiseptic

drugs; write the MOA, adverse effects of hydantoin drugs. (15 M)

5. What are various cardiac arrhythmias? Give the classification of antiarrhythmic

drugs. Write about calcium channel blockers. (15 M)

6. What is hypertension? Give the classification of antihypertensive drugs. Write

about Angiotensin receptor blockers. (15M)

7. Write in detail about

a) Prostaglandins

b) Analgesics (15M)

8. a) What are autocoids? Explain the pharmacological actions of histamine.

b) Classify antihistamines with suitable examples and write a note on non-sedative

antihistamines. (8+7M)

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Code No: 13120/CBCSFACULTY OF PHARMACY

M. Pharmacy (Pharmacology) I-Semester (CBCS) (Backlog) Examination,August 2019

Subject : Bioassays and Clinical ResearchTime: 3 hours Max. Marks: 75

Note: Answer any five questions. All questions carry equal marks.1. a) Define bioassay and describe in detail about types of bioassays. (9)

b) Explain the official bioassay of Acetyle choline. (6)

2. a) Write the principle and procedure for bioassay of insulin. (9)b) Explain any one method for the bioassay of progesterone. (6)

3. a) Describe the principle and bioassay method for Tetanus anti-toxin. (8)b) Write the bioassay method for rabies vaccine. (7)

4. Write short note on:a) Preclinical: development of a drug. 7 ½b) Composition and procedures of IEC. 7 ½

5. Explain in detail about phases of clinical trials. (15)

6. a) Explain about the Informed consent process. (8)b) Write about the application and errors in bioassays. (7)

7. Write the role and responsibilities of following in clinical research: (3X5)a) Sponsorb) Clinical Research coordinatorc) Regulatory Authority

8. a) Explain the bioassay methods for rubella vaccine. (9)b) Write short notes on clinical trials in special population. (6)

(6)

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Code No: 1305/CBCS

FACULTY OF PHARMACYM. Pharmacy I Semester(CBCS) (Common to all) (Backlog) Examination,

July/August 2018

Subject: Pharmaceutical Analytical Techniques

Time: 3 Hours Max.Marks : 75

Note: Answer any five questions. All questions carry equal marks

1. (a) Draw a neat labeled diagram of double beam UV spectrometer. 8(b) Describe different quantitative methods for analysis of single component present

in organic compounds by UV spectroscopy. 72. (a) Explain in brief about interpretation of IR spectra of organic compounds. 10

(b) Explain different sample handling techniques for solids in IR spectroscopy 53. Write about the following

(a) Supercritical fluid chromatography 8(b) Applications of HPTLC technique 7

4. (a) Explain about shielding and deshielding effects. 6(b) Describe different types of detectors used in HPLC instruments. 9

5. (a)Describe the principle and procedure involved in ELISA technique with anexample. 8

(b) Give theory and principle involved in paper electrophoresis technique. 7

6. (a) What are thermal methods and their importance in analysis of pharmaceuticals? 7 ½(b) Make a note on X-Ray crystallography. 7 ½

7. Discuss the principles of DTA and DSC techniques, and write their applicationsalong with the interpretation of thermograms. 15

8. Explain about the following(a) Column efficiency parameters(b) Mobile phase selection(c) Column packing materials 3x5 = 15

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Code No. 1316 / CBCS

FACULTY OF PHARMACY

M. Pharmacy (Pharmacology) I – Semester (CBCS) (Backlog) Examination,

August 2018

Subject: Principles of Toxicology

Time: 3 Hours Max.Marks: 75

Note: Answer any five questions. All questions carry equal marks.

1 a) What are experimental considerations required for assessing possible human

risks? 7½

b) Draw a flow chart for development of preclinical toxicity. 7½

2 Describe the new drug safety assessment as per OECD or ICH guidelines. 15

3 Write notes on:

a) Immunotoxicology testing 7½

b) Dermal toxicity testing 7½

4 Classify poisoning and write general principles of treatment of poisoning. 15

5. Discuss the different methods for the pharmacovigilance data collection. 15

6. Explain the new drug safety assessment as per USFDA guidelines. 15

7. Elaborate the in vitro and in vivo toxicity studies for genotoxicity. 15

8 Write short notes on the following:a) Adverse Events (AE) 7½b) Suspected Unexpected Serious Adverse Reaction (SUSAR). 7½

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Code No: 1315/CBCS

FACULTY OF PHARMACYM. Pharmacy (Pharmacology) I-Semester (CBCS) (Backlog) Examination,

August 2018

Subject : Bioassays and Clinical Research

Time: 3 hours Max. Marks: 75


1. a) Define bioassay and describe in detail about types of bioassay. (9)b) Explain the official bioassay of histamine (6)

2. a) Write the principle and procedure for bioassay of oxytocin. (9)b) Explain any one method for the bioassay of thyrotropin. (6)

3. a) Describe the principle and bioassay method for hepatitis – B. (8)b) Write the bioassay method for BCG vaccine (7) (7)

4. Write short note on:a) Informed consent process. (7)b) Responsibilities and procedures of IEC (8)

5. Explain in detail about phases of clinical trials. (15)

6. a) Explain about the declaration of Helsinki. (7) (7)b) Write about the application and disadvantages of bioassays. (8)

7. Write the role and responsibilities of following in clinical research: (3X5)a) Investigatorb) Contract Research Associatec) Regulatory Authority.

8. a) Explain the bioassay methods for Insulin. (9)b) Write short notes on clinical trials in special population. (6) (6)

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M. Pharmacy (Pharmacology) I – Semester (CBCS) (Backlog) Examination,August 2018

Subject: Molecular Pharmacology and Drug DesignTime: 3 Hours Max.Marks: 75


1 a) Explain in detail about Ion-channel receptors. 10

b) Write a note on regulation of receptors. 5

2 a) Describe about protein kinase-A and protein kinase-G. 10

b) Write a note on endothelin. 5

3 a) Classify cholinergic receptors .Explain their physiological role. 2+8

b) Describe in brief about dopamine receptors. 5

4 a) Explain any four herbal anti-cancer drugs. 10

b) Write a note on evaluation of herbal extracts. 5

5 a) Explain in brief about high throughput screening. 8

b) Write note on QSAR. 7

6 a) Describe about gap junctions. 8

b) Explain in brief about phosphodiesterase enzymes. 7

7 a) Write a note on serotonin receptors and their modulators. 4+4

b) Write in brief about reverse pharmacognosy. 7

8 Write a note on following: 3x5

a) Bio-precursor prodrugs.

b) Second messengers.

c) Biosensors.****


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Code No. 1314/CBCS

FACULTY OF PHARMACYM. Pharmacy (Pharmacology) I-Semester (CBCS) (Backlog) Examination,

August 2018

Subject: Advanced Pharmacology

Time: 3 Hours Max. Marks: 75


1. Write in detail about various biotransformation reactions with examples. (15 M)

2. Explain the general steps involved in neurotransmission. Add a note on Nor-

adrenergic transmission. (15 M)

3. Classify para sympathomimetic drugs. Write in detail about pharmacology of Acetyl

chlorine. (15 M)

4. Write the classification of Non-narcotic analgesics and explain in detail any three

classes of drugs. (15 M)

5. What is hypertension? Classify the drugs used in treatment of hypertension.

Explain the MOA, therapeutic uses and adverse effects of ACE inhibitors and β-

blockers. (2+5+8 M)

6. Write a note on

a. The biosynthesis and pharmacology of serotonin (8 M)

b. Pharmacology of histamine (7 M)

7. a) Classify anti histaminics and explain the pharmacology of histamine (8 M)

b) Write a note on mechanism of action of H1 & H2 blocker drugs (7 M)

8. Write short notes on (8+7 M)

a) Hypnotics and sedatives b) Drug addiction & dependence

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Code No. 4140FACULTY OF PHARMACY

M. Pharmacy I-Semester (Common to All) (Main) Examination, March 2017

Subject: Pharmaceutical Analytical TechniquesTime: 3 Hours Max. Marks: 75


1 (a) Explain wood ward fisher rules for calculating absorption maximum forunsaturated hydrocarbons with an example. (7)

(b) Write about difference and derivative spectroscopy techniques. (8)

2 (a) Explain in brief about interpretation of IR spectra of organic compounds. (10)(b) Give the absorption frequencies of the following functional groups (5)

(i) Ester(ii) Aldehydes(iii) Carboxylic acids(iv)Alcohols(v) Amide

3 (a) Write about different derivation techniques used in gas chromatography. (8)(b) Give the different applications of HPLC techniques. (7)

4 Write short notes on the following: (15)(a) Principle of NMR(b) Chemical shifts in 1H-NMR(c) Spin-spin coupling in 1H-NMR

5 (a) Describe the principle and procedure involved in ELISA technique with anexample. (8)

(b) Give theory and principle involved in electrophoresis technique. (7)

6 (a) What is Nitrogen rule in mass spectrometry? Explain with suitable examples. (5)(b) Make a note on X-Ray crystallography (5)(c) Explain powder diffraction method with its applications (5)

7 (a) Discuss the principles of DTA and DSC techniques. (5)(b) Describe the two techniques used in getting DSC thermograms. (10)

8 Explain about the following : (3x5)(a) Column efficiency parameters(b) Mobile phase selection(c) Column packing materials

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M. Pharmacy (Pharmacology) I-Semester (Main) Examination, March 2017Subject: Principles of Toxicology



1 (a) What are experimental considerations required for assessing possible humanrisks? (8)

(b) Draw a flow chart for development of preclinical toxicity. (7)

2 Explain the new drug safety assessment as per EMEA guidelines. (15)

3 Write a notes on :(a) Mutagenicity testing (8)(b) Allergenicity testing (7)

4 Discuss the following in detail:(a) Lead poisoning (7)(b) Opium poisoning (8)

5 Discuss the risk-benefit assessment and management in pharmacovigilance. (15)

6 Describe the USFDA guidelines for the assessment of new drug safety. (15)

7 Elaborate the in vitro and in vivo toxicity studies for genotoxicity. (15)

8 Write a short note on the following:(a) Serious Adverse Events (SAE) (7)

(b) Suspected unexpected Serious Adverse Reaction (SUSAR) (8)

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M. Pharmacy (Pharmacology) I-Semester (Main) Examination, March 2017

Subject: Molecular Pharmacology and Drug DesignTime: 3 Hours Max. Marks: 75


1 (a) Write a note on receptor theory. (7)(b) Describe in detail about G-Protein Coupled Receptors. (8)

2 (a) Write a note on protein kinase-A and nitric oxide. (7)(b) Explain in brief about neurosteroids and neuropeptides. (8)

3 (a) Describe in detail about recent advances in angiotensin receptors. (10)(b) Write a note on GABA-A receptor. (5)

4 (a) Describe in detail about Phytochemical screening techniques for herbal extract. (10)(b) Write a note on concept of reverse pharmacognosy. (5)

5 (a) Describe in detail about biochemical based high throughput screeningtechniques. (10)

(b) Write a note on solid phase synthesis. (5)

6 (a) Write a note on third messengers and enzymes linked receptors. (8)(b) Explain in brief about opioid receptors. (7)

7 (a) Describe in detail about herbal anti-diabetics and anti-hyperlipidimics. (10)(b) Write note on regulation of receptors. (5)

8 Write a note on following:(a) Nicotinic receptors (5)(b) Bio-Precursor prodrugs (5)(c) Cytokines (5)

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Subject: Advanced PharmacologyTime: 3 Hours Max. Marks: 75


1 Explain general principles of chemical transmission. Add a note on cholinergictransmission. (8)

2 What are sympathomimetics ? Classify them. Explain pharmacology ofadrenaline. (1+6+8)

3 Classify antidepressants? Describe the pharmacology of TricyclicAntidepressants. (6+9)

4 Write about the following: (7+8)(a) Pharmacology of purgatives(b) Drug addiction to dependence

5 Classify various types of seizures and drugs used to treat them. (7+8)

6 What are auto coids? Discuss the pharmacology of 5-HT. Add a note on 5HTagonist and antagonist. (1+7+7)

7 Explain biochemical mediators involved in allergy. Write a note oninflammation. (8+7)

8 Discuss the drug treatment for : (8+7)(a) Asthma(b) Emesis

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Subject: Bioassays and Clinical ResearchTime: 3 Hours Max. Marks: 75


1 (a) Define bioassay. Write the principle and advantages of bioassay. (1+2+2)(b) Describe in brief about types of bioassay. (10)

2 (a) Explain the principle and procedure for bioassay of acetylcholine. (7)(b) Describe the bioassay methods for insulin. (8)

3 (a) Write the principle and procedure for bioassay of histamine. (9)(b) Explain any one method for bioassay of serotonin. (6)

4 (a) Describe the principle and bioassay methods for diphtheria vaccine. (9)(b) Write the bioassay method for rota virus vaccine. (6)

5 Explain in detail about phases of clinical trials. (15)

6 (a) Write a note on errors in bioassay. (5)(b) Disadvantages of bioassay. (5)(c) Write a note on applications of bioassay. (5)

7 (a) Write a note on new drug application. (9)(b) Explain about the declaration of helisinki. (6)

8 Write the role and responsibilities of following in clinical research.(a) Sponsorer (5)(b) Investigator (5)(c) Clinical research associate (5)

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Code No. 4097 / NFACULTY OF PHARMACY

M. Pharmacy (Common to All) I-Semester(New) (Suppl.) Examination, October 2016(Except Pharmacognosy / Ind. Pharm.)



1 (a) Explain the following terms with respect to UV-visible spectroscopy. (8)(i) Chromophore (ii) Auxo chrome(iii) Bathochromic shift (iv) Hypsochromic shift

(b) Describe the effect of conjugation and pH on UV absorption of organicmolecules. (7)

2 (a) Write the principle and instrumentation of Fourier Transform Infra Red (FTIR)spectrophotometer with a neat labeled diagram. List out its advantages overconventional IR instrument. (10)

(b) What are ‘IR active and IR inactive groups’? Give the absorption frequencies forthe following functional groups. (3+2)(i) Carboxylic acid (ii) Aldehyde (iii) Primary amine (iv) Alcohol

3 (a) What is spin-spin coupling? Explain with suitable examples. (8)(b) Explain the term ‘chemical shift’? Discuss the factors affecting chemical shift. (7)

4 (a) List out various ionization techniques in mass spectrometry. Explain electronimpact and chemical ionization techniques. (8)

(b) Explain the following:(i) Nitrogen Rule (7)(ii) Molecular ions(iii) Meta stable ion

5 (a) Give the principle of Gas chromatography. Explain any three derivatisationmethods. (9)

(b) Write the applications of Gas chromatography in pharmaceutical analysis. (5)

6 (a) Explain the principle and working of HPLC with a schematic diagram. (8)(b) Discuss the principle and applications of flash chromatography. (7)

7 (a) Write the principle and instrumentation of capillary electrophoresis. (7)(b) Explain the principle, applications and limitations of ELISA. (8)

8 (a) Explain Bragg’s equation and Miller indices. Write the applications ofcrystallographic studies. (8)

(b) Briefly explain the principle and working procedure of TGA. (7)

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M. Pharmacy (Pharmacology) I-Semester (New) (Suppl.) Examination, November 2016



1 (a) Define Neurotransmitter. Explain various steps involved in neurotransmission. (8)(b) Explain Non-adrenergic and non-cholinergic transmission (NANC). (7)

2 Classify sympathomimetics agents with suitable examples and explain thepharmacology of catecholamines. (15)

3 What are antihypertensives? Classify them with suitable examples. Explain thepharmacology ACE inhibitors. (15)

4 Explain the the following:(a) COX-inhibitors (8)(b) Adverse effects of antibiotics (7)

5 (a) What are anti-anxiety drugs? Explain in detail the pharmacology of benzodia-zepines. (8)

(b) Write a note on anti-diabetic agents. (7)

6 Discuss about cell and biochemicals mediators involved in allergy andinflammation. (15)

7 Write a note on opioid analgesics and drug addiction and dependence. (8+7)

8 (a) Classify antidepressants. Describe the pharmacology of tricyclicanticepressents. (8)

(b) What is arrhythmia? Classify drugs used in cardiac arrhythmias and discussthe pharmacology of Quinidine. (7)

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M. Pharmacy (Pharmacology) I-Semester (New) (Suppl.) Examination, November 2016

Subject: Principles of ToxicologyTime: 3 Hours Max. Marks: 75


1 (a) What are experimental considerations required for assessing possible risks? (8)(b) Draw a flow chart for development of preclinical toxicity. (7)

2 Explain the new drug safety assessment as per ICH guidelines. (15)

3 Write note on :(a) Allergenicity testing (8)(b) Ocular toxicity testing (7)

4 Discuss the following in detail :(a) Alcohol poisoning (7)(b) Food poisoning (8)

5 Discuss the different methods for the pharmacovigilance data collection. (15)

6 Describe the USFDA guidelines for the assessment of new drug safety. (15)

7 Elaborate the in vitro and in vivo toxicity studies for mutagenicity. (15)

8 Write short note on the following:(a) Adverse Events (AE) (8)(b) Suspected unexpected serious Adverse Reaction (SUSAR) (7)

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M. Pharmacy (Pharmacology) I-Semester (New)(Suppl.) Examination, October 2016

Subject: Molecular Pharmacology and Drug DesignTime: 3 Hours Max. Marks: 75


1 (a) Write a note on JAK-STAT pathway. (6)(b) Describe in detail about G-Protein Coupled Receptors. (9)

2 (a) Write a note on neuropeptides. (9)(b) Explain brief about nitric oxide. (6)

3 (a) Describe in brief about endothelin and their modulators. (9)(b) Write a note on histamine receptors. (6)

4 (a) Describe in detail about Phytochemical screening techniques for herbalextract. (10)

(b) Write a note on concept of reverse pharmacognosy. (5)

5 (a) Describe in detail about biochemical based high throughput screeningTechniques. (10)

(b) Write a note on solid phase synthesis. (5)

6 (a) Write a note on third messengers. (6)(b) Explain in brief about opioid receptors. (9)

7 (a) Describe in detail about herbal anti-diabetics and anti-hyperlipidimics. (10)(b) Write a note on regulation of receptors. (5)

8 Write a note on the following:(a) Nicotinic receptors (5)(b) Bio-Precursor prodrugs (5)(c) Cytokines (5)

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M. Pharmacy (Pharmacology) I-Semester (New)(Suppl.) Examination, November 2016



1 (a) Write the applications of bioassay method. (7)(b) Describe in brief about graded bioassay method. (8)

2 (a) Explain the principle and procedure for bioassay of serotonin. (7)(b) Describe the bioassay methods for histamine. (8)

3 (a) Write the principle and procedure for bioassay of oxytocin. (9)(b) Explain any one method for bioassay of vasopressin. (6)

4 (a) Describe the principle and bioassay method for tetanus antitoxin. (9)(b) Write the bioassay method for rubella vaccine. (6)

5 Explain in detail about phases of clinical trials. (15)

6 (a) Write the composition and responsibilities of IRB. (7)(b) Describe in briefly about clinical trials for special populations. (8)

7 (a) Write a note on informed consent process. (8)(b) Explain about the ethics in clinical trials. (7)

8 Write the role and responsibilities of following in clinical research(a) Coordinator (5)(b) Auditor (5)(c) Contract research organization (5)

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M. Pharmacy (Common to All) I-Semester (New) (Main) Examination, April 2016(Except Pharmacognosy / Ind. Pharm.)



1 (a) Explain Woodward – Fieser rules for calculating max for unsaturatedhydrocarbons. (5)

(b) Describe various electronic transitions in UV-visible spectroscopy. (5)(c) List out different IR instruments and discuss their advantages and

Disadvantages. (5)

2 (a) Describe various sample-handling techniques for IR spectroscopy. (8)(b) Write a short note on 13C NMR. (7)

3 (a) How do you determine the molecular formula of a compound with the followingisotopic abundance? (6)

M+ M+1 M+2m/z 94 95 96% R.A. 100 1.1 98

(b) Explain the following with examples. (9)(i) Nitrogen Rule(ii) Shielding and deshielding(iii) Spin-spin coupling

4 (a) Explain the principle of gas chromatography and discuss instrumentation of GCwith a labeled diagram. Give its applications. (9)

(b) Describe the principle and working of any two detectors used in GCinstruments. (6)

5 (a) Explain the principle of HPLC. Describe the stationary phases used in HPLCinstruments. (8)

(b) Discuss the principle and applications of supercritical fluid chromatography. (7)

6 Write a note on :(a) Miller indices and Bragg’s equation (8)(b) SDS-gel electrophoresis (7)

7 (a) Write the principle and instrumentation of zone electrophoresis. (7)(b) Explain the principle, applications and limitations of RIA. (8)

8 (a) List out different thermal analytical techniques. Briefly explain the theory,instrumentation and applications of DSC. (10)

(b) Explain the rotating crystal technique for X-ray diffraction studies. (5)

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M. Pharmacy (Pharmacology) I-Year I-Semester(New) (Main) Examination, April 2016

Subject: Molecular Pharmacology and Drug Design



1 (a) Write a note on regulation receptors. (7)(b) Describe in detail about Ion channel receptors. (8)

2 (a) Write a note on protein kinase-C and cytokines. (7)(b) Explain in brief about phosphodiesterase enzymes. (8)

3 (a) Describe in detail about types of adrenergic receptors. (10)(b) Write a note on GABA-B receptor. (5)

4 (a) Describe in detail about Phytochemical screening techniques for herbal extract. (10)(b) Write a note on concept of reverse pharmacognosy. (5)

5 (a) Describe in detail about QSAR techniques. (10)(b) Write a note on reporter gene assay. (5)

6 (a) Write a note on second messengers. (8)(b) Explain in brief about Imidazoline receptors. (7)

7 (a) Describe in detail about herbal anti-AIDS and anti-hyperlipidimics. (10)(b) Write a note on nuclear receptors. (5)

8 Write a note on following:(a) Scintillation proximity assays (5)(b) Chemical delivery system (5)(c) Dopamine receptors (5)

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M. Pharmacy (Pharmacology) I-Year I-Semester (New) (Main) Examination, April 2016



1 (a) Describe about the bioassay methods. (8)(b) Write the advantages and disadvantages of bioassay. (7)

2 (a) Explain the principle and procedure for bioassay of heparin. (7)(b) Describe the qualitative bioassay methods for digitals. (8)

3 (a) Write the principle and bioassay methods for oxytocin. (10)(b) Explain any one method for bioassay of adrenaline. (5)

4 (a) Describe about the bioassay for diphtheria anti-toxin. (9)(b) Explain the bioassay method for hepatitis – B Vaccine. (6)

5 Explain in detail about good clinical practice. (15)

6 (a) Explain the bioassay of tetanus vaccine. (10)(b) Write a note on phase-II clinical trial. (5)

7 (a) Write a note on methods of post marketing surveillance. (9)(b) Explain about the NDA. (6)

8 Write the role and responsibilities of following in clinical research.(a) Regulatory authority (5)(b) Auditor (5)(c) Sponsorer (5)

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Hyderabad

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Hyderabad

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M. Pharmacy (Pharmacology) I-Semester(New) (Main) Examination, April 2016Subject: Principles of Toxicology



1 Write a detailed note on determination of LD50 as per OECD – 425 guideline. (15)

2 Describe the new drug safety assessment as per EMEA guidelines. (15)

3 Write short note on the following:(a) Immunotoxicology testing (8)(b) Dermal toxicity testing (7)

4 Classify poisoning and write general principles of treatment of poisoning. (15)

5 Define pharmacovigilance. Discuss periodic safety update Reports (PSUR) for marketeddrugs. (15)

6 Explain the OECD guidelines for the assessment of new drug safety. (15)

7 Explain various studies for carcinogenicity testing. (15)

8 Discuss the following in detail:(a) Serious Adverse Event (SAE) (7)(b) Serious Adverse Reaction (SAR) (8)

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Hyderabad

Library


Hyderabad

OU - 17

05 O

U - 17

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M. Pharmacy (Pharmacology) I-Semester(New) (Main) Examination, April 2016



1 Explain general principles of chemical transmission. Add a note on noradrenergictransmission. (15)

2 Classify parasympathamimetics drugs. Write in detail about the pharmacology ofacetylcholine. (15)

3 Explain the following:(a) Depression and mania (8)(b) Drugs acting at NMJ (7)

4 What are autocoids? Discuss the pharmacology of 5HT. Add a note on 5-HT agonistsand antagonists. (1+7+7)

5 Explain the disease pathology and therapeutic agents for allergy and COPD. (15)

6 What are sedatives and hypnotics? Classify them and explain the pharmacology ofphenobarbitone and diazepam. (15)

7 (a) What is congestive heart failure? Discuss various categories of drugs used in itstreatment. (8)

(b) Explain the pharmacology of antifungal agents. (7)

8 Discuss the drug treatment for :(a) Diarrhea (5)(b) Irritable bowel syndrome (5)(c) Emesis (5)

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Hyderabad

Documents

M. Pharmacy I –Sem. (CBCS) (Common to all) (Backlog ...gprcp.ac.in/Qpmp/2016/all cology 1 all.pdf · 1. a) Define bioassay and describe in detail about types of bioassay. (9) b)