65
Médicaments et déficit en Glucose-6-Phosphate Déshydrogénase (G6PD) février 2008 Index par substances actives Agence française de sécurité sanitaire des produits de santé 143-147 boulevard Anatole France F - 93285 Saint-Denis Cedex www.afssaps.sante.fr

M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

  • Upload
    others

  • View
    6

  • Download
    0

Embed Size (px)

Citation preview

Page 1: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

Médicaments et déficit en Glucose-6-PhosphateDéshydrogénase (G6PD)

février 2008

Index par substances actives

Agence française de sécurité sanitaire des produits de santé

143-147 boulevard Anatole France F - 93285 Saint-Denis Cedex

www.afssaps.sante.fr

Page 2: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

2

Médicaments et déficit en Glucose-6-Phosphate Déshydrogénase (G6PD)

MESSAGES CLES Le déficit en G6PD est une maladie génétique atteignant les globules rouges. Elle est due à un déficit en une enzyme, la Glucose-6-Phosphate Déshydrogénase, indispensable à la survie des globules rouges. Les sujets déficients en G6PD sont susceptibles de développer une hémolyse aiguë en cas de stress oxydant. Certains aliments ou médicaments oxydants peuvent provoquer cette hémolyse et sont donc, dans la mesure du possible, à éviter.

Dans ce livret, vous trouverez des informations sur cette maladie, une liste des substances susceptibles de provoquer une hémolyse (destruction des globules rouges) chez les sujets déficients en G6PD ainsi que la conduite à tenir si vous êtes amené à prescrire ou utiliser ces médicaments. LE DEFICIT EN G6PD Le déficit en G6PD, encore appelé favisme, est le plus fréquent des déficits héréditaires enzymatiques du globule rouge. Il touche environ 420 millions de per-sonnes dans le monde, avec une fréquence plus éle-vée dans les pays du pourtour méditerranéen, d’Afri-que tropicale, du Moyen-Orient et d’Asie tropicale et sub-tropicale. Les populations d’origine Africaine et hispaniques de l’Amérique du Nord, du Sud et des Antilles sont également touchées. D’après les données de l’OMS, datant de 1989, la prévalence de la maladie serait de 0.39% en Europe, ce qui représenterait en France 120 000 déficitaires de sexe masculin et environ 1 400 nouveaux cas par an parmi les nouveau-nés mâles. Cependant, d’après les dernières estimations de l’association Vigifa-visme* et de son Conseil Scientifique, le nombre de sujets déficitaires en France serait beaucoup plus éle-vé, compte tenu des migrations Sud Nord depuis les « Régions à risque élevé » du Monde vers la France, et atteindrait en 2007, plus de 250 000 personnes en France métropolitaine et dans les DOM-TOM. La maladie est transmise génétiquement sur le mode récessif, lié au chromosome X. Elle touche en grande majorité les hommes, dit hémizygotes, tandis que les femmes sont le plus souvent, seulement transmettri-ces de l’anomalie. Il existe cependant de rares cas de femmes, dites homozygotes, chez lesquelles le déficit s’exprime. Chez les femmes hétérozygotes, la situa-tion est complexe car en raison de l’inactivation au hasard d’un des chromosomes X, elles possèdent

deux populations d’hématies présentes en proportion variable d’un individu à l’autre. Une absence totale d’activité n’a jamais été décrite chez l’homme car les autres voies de régénération des différents facteurs d’oxydoréduction cellulaire sont insuffisantes pour assurer la vie. La principale manifestation clinique du déficit en G6PD est l’hémolyse qui peut se traduire selon trois tableaux cliniques : - l’anémie hémolytique aiguë, induite par l’ingestion de certains médicaments ou aliments, ou au cours d’une infection, - l’anémie hémolytique chronique, - et l’ictère néonatal, avec dans les cas les plus sévè-res et non traités des séquelles neurologiques. Le plus souvent, en dehors des formes d’anémie hé-molytique chronique qui sont rares, le patient défici-taire ne présente aucun symptôme particulier. Une grande hétérogénéité clinique est observée selon la nature moléculaire du déficit (variant) et l’activité résiduelle de l’enzyme dans le globule rouge. La clas-sification de l’OMS du déficit en G6PD se fonde sur le niveau d’activité érythrocytaire de l’enzyme et l’impor-tance des manifestations cliniques : classe I : déficit sévère (1 à 2 % d’activité enzymatique résiduelle) ; classe II : déficit intermédiaire (3 à 10 % d’activité en-zymatique) ; classe III : déficit modéré (10 à 40 % d’activité enzy-matique). ROLE DE LA GLUCOSE-6-PHOSPHATE DESHYDROGE-NASE La Glucose-6-Phosphate Déshydrogénase est une en-zyme cytoplasmique présente dans toutes les cellules. Elle catalyse la première réaction de la voie des pento-ses-phosphates (transformation des sucres en énergie nécessaire à la vie).

* Association Vigifavisme : Association française des personnes atteintes du déficit génétique en G6PD / www.vigifavisme.com

Page 3: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

3

Elle produit du : !"ribose 5 phosphate (qui servira ultérieurement à la

synthèse des nucléotides) ; !"NADPH, coenzyme et principal donneur d'hydrogène

dans de nombreuses réactions de biosynthèse. Le NADPH est aussi indispensable à la destruction du peroxyde d'hydrogène (H2O2), substance hautement toxique pour la cellule.

Avec une G6PD très peu active, il y a un arrêt de la production de NADPH par la voie des pentoses-phosphates ce qui empêche la réduction du glutathion et donc la destruction du peroxyde d'hydrogène. La G6PD joue ainsi un rôle essentiel dans la réduction des agents oxydants puisque sans NADPH, le pe-roxyde d'hydrogène ne sera pas réduit et la cellule sera lysée (éclatement de la cellule par rupture de la membrane). Cas des globules rouges : La G6PD est normalement présente dans tous les tis-sus mais son déficit s’exprime essentiellement dans les globules rouges au sein desquels aucune autre enzyme ne permet la production de NADPH, à l’inverse des autres cellules nucléées de l’organisme. En l’absence de NADPH, toute agression oxydative entraîne une altération des principaux constituants des globules rouges (membrane et hémoglobine). L’hémoglobine dénaturée précipite à l’intérieur de la cellule pour former des corpuscules appelés corps de Heinz, eux-mêmes générateurs de radicaux oxygénés libres toxiques. Cette dénaturation de l’hémoglobine et l’oxydation des constituants membranaires condui-sent à une hémolyse (destruction des globules rou-ges). Suite à l’hémolyse, les globules rouges sont dégradés dans le foie qui transforme l’hémoglobine en biliru-bine. La bilirubine peut alors former des calculs biliai-res qui obstruent la vésicule biliaire et peuvent être à l’origine d’un ictère. Dans certains cas, l’hémoglobine peut aussi être éliminée dans les urines et provoquer une hémoglobinurie. Lorsque cette hémolyse est importante, elle entraîne une anémie, se traduisant par un état défaillant de l’organisme. PRINCIPAUX SYMPTOMES AMENANT A CONSULTER / CONDUISANT AU DIAGNOSTIC Quelques heures voire quelques jours après la prise d’un agent déclenchant, une crise brutale d’hémolyse peut survenir avec : !"fièvre, pâleur, céphalées !"douleurs abdominales et lombaires !"émissions d’urines foncées !"fatigue ou anorexie inexpliquée !"ictère.

En période néonatale, le déficit peut se révéler par une jaunisse (ictère néo-natal) qui débute vers les 2ème et 3ème jours de vie. En cas de crise de coliques hépatiques ou de réappari-tion d'un ictère, une lithiase doit être recherchée par échographie. LE TRAITEMENT En règle générale, le traitement est surtout préventif en excluant quelques aliments (se reporter à la rubri-que « conseils diététiques ») et en évitant, dans la me-sure du possible, la prise de certains médicaments. En cas de forme sévère, une transfusion sanguine peut être nécessaire, voire une exsanguino-transfusion. Il est à noter que le don du sang de la part d'un sujet déficitaire est interdit, et l'autotransfusion n'est pas conseillée. FACTEURS DECLENCHANTS Le facteur déclenchant d’une hémolyse peut être l’in-gestion de fèves, légume qui a donné à la maladie le nom de favisme. Dans ce cas, l'hémolyse et l'anémie peuvent survenir quelques heures après l'ingestion. Elles peuvent être très sévères, avec une insuffisance rénale aiguë associée, et demandent un traitement d'urgence par transfusion ou par exsanguino-transfusion. Elles surviennent à tous les âges de la vie. Certains médicaments peuvent aussi être responsa-bles d’une hémolyse chez les sujets déficitaires en G6PD. L'influence de ces produits est variable selon l’individu et le type de déficit. La tolérance individuelle est imprévisible, les sujets déficitaires doivent donc impérativement suivre les recommandations des lis-tes de médicaments et d’aliments dangereux. CONSEILS DIETETIQUES Les sujets déficients en G6PD sont susceptibles de développer une hémolyse aiguë suite à l’ingestion d’a-liments. L’Agence Française de Sécurité Sanitaire des Aliments (Afssa) a élaboré des recommandations rela-tives à l’alimentation des personnes souffrant de défi-cit en G6PD, préconisant !"de ne pas consommer de fèves, quel que soit leur

mode de préparation et de consommation !"de ne pas consommer de boissons contenant de la

quinine !"d’être vigilant en cas de consommation importante

de produits naturellement riches en vitamine C ou de denrées enrichies en vitamine C (comme certains jus de fruits) ; l’Afssa recommande également de ne pas

Page 4: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

4

consommer de compléments alimentaires à base de vitamine C.

Ces recommandations sont disponibles sur le site in-ternet de l’Afssa à l’adresse suivante : http://www.afssa.fr/Documents/NUT2006sa0033.pdf. Dans le cas d’une hémolyse chronique La supplémentation en acide folique (vitamine B9) ne doit pas être systématique même si le risque de ca-rence est plus important chez les sujets déficitaires que dans la population générale. Un apport de 5 à 10 mg/jour est recommandé de façon systématique et intermittente (1 à 2 semaines par mois) dans les cas suivants : hémolyse chronique, grossesse program-mée ou en cours, et suites d'un accident infectieux.

La supplémentation en tocophérol (vitamine E) est d'une utilité encore mal connue, mais se justifie quand l'hémolyse oxydative est évidente. La supplémentation médicamenteuse en fer est à évi-ter tant que la carence n'a pas été démontrée. Pour les formes hémolytiques survenant au cours de la grossesse, et en l'absence de besoin transfusion-nel, les apports protéiques doivent être particulière-ment bien équilibrés.

Février 2008

Page 5: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

5

Préambule

______________________________________________

Ce livret est un outil d’aide à l’utilisation ou à la prescription de certains médicaments ayant un risque poten-

tiel ou avéré de provoquer une anémie hémolytique chez les sujets déficitaires en G6PD.

Ce livret reprend les conclusions des évaluations menées par un groupe de travail ad hoc « Médicaments et

déficit en G6PD » de l’Afssaps, ces recommandations ayant fait l’objet d’une présentation à la Commission

d’Autorisation de Mise sur le Marché.

L’accès à l’information se fait par substance active, présenté par ordre alphabétique. Un référentiel reprend

également par ordre alphabétique l’ensemble des dénominations commerciales des spécialités correspon-

dantes.

Pour chaque substance active, le niveau de risque associé définit une conduite à tenir lors de l’utilisation de

ces substances parmi les cinq suivantes :

!" Contre-indiquée,

!" Déconseillée (sauf situation particulière) en raison de cas observés d’hémolyse aiguë,

!" Déconseillée (sauf situation particulière) en raison de l’appartenance à une classe pharmacologique à

risque, ou d’un risque potentiel d’hémolyse,

!" Déconseillée à posologie élevée, c’est-à-dire supérieure à la dose usuelle journalière,

!" Utilisation possible après analyse des données disponibles (littérature et pharmacovigilance).

Cette dernière catégorie concerne les substances actives (signalées par *) pour lesquelles différentes

listes disponibles sur internet (Centres Régionaux de Pharmacovigilance, Association Vigifavisme) men-

tionnaient une précaution d’emploi ou une contre-indication. Celles-ci avaient été attribuées sur la

base d’une analyse d’articles issus de la littérature ; cependant, dans de nombreux cas, les articles

étaient anciens ou contradictoires. L’évaluation menée par l’Afssaps a ainsi permis de montrer qu’il

n’existait pas de risque identifié d’hémolyse avec ces substances chez les sujets déficitaires en G6PD.

Contre-indiquée

Déconseillée (sauf situation particulière) en raison de cas observés

d’hémolyse aiguë

Déconseillée (sauf situation particulière) en raison de l’appartenance à une classe pharmacologi-que à risque, ou d’un risque

potentiel d’hémolyse

Déconseillée à posologie

élevée

Utilisation possible

après analyse des données disponi-bles (littérature et

pharmacovigilance)

Page 6: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

6

L’information se décompose en quatre rubriques :

!" une première rubrique « Recommandations particulières à l’attention des professionnels de santé » men-

tionne les recommandations correspondantes à l’utilisation du produit ;

!" une deuxième rubrique « Conduite à tenir à l’attention des patients déficitaires en G6PD » ;

!" une troisième « Informations complémentaires » apporte si nécessaire un complément d’informations ;

!" une quatrième rubrique référencie l’ensemble des dénominations commerciales des spécialités corres-

pondantes à chaque substance active (les spécialités commercialisées en France à la date de publica-

tion de ce document sont indiquées en couleur). Les spécialités citées peuvent ne contenir que la subs-

tance active concernée par le déficit en G6PD ; cependant, dans certains cas, il s’agit d’une association

avec d’autres substances actives qui soit ne sont pas à risque pour les sujets déficitaires en G6PD, soit

n’ont pas été évaluées en raison de l’absence de données permettant à l’heure actuelle d’identifier un

risque d’hémolyse chez ces sujets déficitaires.

Ces informations seront actualisées en fonction de l’évolution des connaissances et de l’état de commerciali-sation des spécialités concernées.

Page 7: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

7

Index

______________________________________________

Acide acétylsalicylique

Acide ascorbique

Acide nalidixique

Acide pipémidique

Bénorilate

Bleu de méthylène (voies buccale et ophtalmique)*

Bupivacaïne*

Carbasalate calcique

Carbutamide

Chloramphénicol (voie ophtalmique)*

Chloroquine

Ciprofloxacine (voies orale et injectable)

Ciprofloxacine (voies ophtalmique et auriculaire)*

Colchicine*

Dapsone

Diéthylamine*

Dihydroquinidine*

Dimenhydrinate*

Dimercaprol

Doxorubicine*

Enoxacine

Fève de Saint-Ignace*

Fluméquine

Glibenclamide

Glibornuride

Gliclazide

Glimépiride

Glipizide

Hydroxychloroquine

Isoniazide (voies orale et injectable)*

Lévodopa*

Lévofloxacine (voies orale et injectable)

Loméfloxacine

Méfloquine*

Monoxyde d’azote*

Morpholine*

Moxifloxacine

Nitrofurantoïne

Nitroprussiate*

Noramidopyrine / Métamizole sodique

Norfloxacine (voie orale)

Norfloxacine (voie ophtalmique)*

Ofloxacine (voies orale et injectable)

Ofloxacine (voies ophtalmique et auriculaire)*

Paracétamol

Para-aminosalicylate de sodium (PAS)*

Péfloxacine (voies orale et injectable)

Phénazone (voie locale)

Phénazone (voie auriculaire)*

Phénylbutazone*

Phénytoïne*

Phytoménadione

Prilocaïne

Probénécide*

Proguanil*

Propylène glycol*

Pyriméthamine*

Quinidine*

Quinine

Rasburicase*

Spiramycine (voies orale et injectable)

Streptomycine*

Succimer*

Sulfacétamide

Sulfadiazine (voie orale)

Sulfadiazine (voie locale)

Sulfadoxine

Sulfafurazol

Sulfaguanidine

Sulfaméthizol

Sulfaméthoxazole

Sulfasalazine

Thiamphénicol (voies orale et injectable) *

Trihexyphénidyle*

Triméthoprime (voies orale et injectable)

Trinitrine*

Page 8: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

8

Contre-indiquée

!" Acide nalidixique !" Dapsone !" Nitrofurantoine !" Noramidopyrine / Métamizole sodi-

que

!" Rasburicase !" Sulfadiazine (voie orale) !" Sulfafurazol !" Sulfaguanidine

!" Sulfaméthoxazole (voies orale et injectable)

!" Sulfasalazine !" Triméthoprime (voies orale et injec-

table)

Déconseillée (sauf situation particulière) en raison de cas observés d’hémolyse aiguë

!" Chloroquine !" Ciprofloxacine (voies orale et injec-

table) !" Dimercaprol

!" Glibenclamide !" Lévofloxacine (voies orale et injec-

table) !" Norfloxacine (voie orale)

!" Phytoménadione (vitamine K1) !" Spiramycine (voies orale et injecta-

ble) !" Sulfadiazine (voie locale)

Utilisation possible après analyse des données disponibles (littérature et pharmacovigilance)*

!" Bleu de méthylène (voies buccale et ophtalmique)*

!" Bupivacaïne* !" Chloramphénicol* (voie ophtalmi-

que) !" Ciprofloxacine (voies ophtalmique

et auriculaire)* !" Colchicine* !" Diéthylamine* !" Dihydroquinidine* !" Dimenhydrinate* !" Doxorubicine* !" Fève de Saint -Ignace*

!" Isoniazide (voies orale et injecta-ble)*

!" Lévodopa* !" Méfloquine* !" Monoxyde d’azote* !" Morpholine* !" Nitroprussiate* !" Norfloxacine (voie ophtalmique)* !" Ofloxacine (voies ophtalmique et

auriculaire)* !" Para-aminosalicylate de sodium

(PAS)* !" Phénazone (voie auriculaire)*

!" Phénylbutazone* !" Phénytoïne* !" Probénécide* !" Proguanil* !" Propylène glycol* !" Pyriméthamine* !" Quinidine* !" Streptomycine* !" Succimer* !" Thiamphénicol* !" Trihexyphénidyle* !" Trinitrine*

Déconseillée (sauf situation particulière) en raison de l’appartenance à une classe pharmacologique à risque, ou d’un risque potentiel d’hémolyse !" Acide pipémidique !" Carbutamide !" Enoxacine !" Fluméquine !" Glibornuride !" Gliclazide !" Glimépiride !" Glipizide

!" Hydroxychloroquine !" Loméfloxacine !" Moxifloxacine !" Ofloxacine (voies orale et injecta-

ble) !" Péfloxacine (voies orale et injecta-

ble) !" Phénazone (voie locale)

!" Prilocaïne !" Quinine !" Sulfacétamide !" Sulfadoxine !" Sulfaméthizol

Déconseillée à posologie élevée

!" Acide acétylsalicylique !" Acide ascorbique

!" Bénorilate !" Carbasalate calcique

!" Paracétamol

Memento

* substances actives pour lesquelles différentes listes disponibles sur internet (Centres Régionaux de Pharmacovigilance, Asso-ciation Vigifavisme) mentionnaient une précaution d’emploi ou une contre-indication. L’évaluation de ces substances a montré qu’il n’existait pas de risque identifié d’hémolyse chez les sujets déficitaires en G6PD.

Page 9: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

!

"!

#$%&!'%(!()*%+(!,-.+%).(!/0)1!/23454+!%1!6789:!/%(!5;(!/0$2<-'=(%!;4>)?!-1+!2+2!.;,,-.+2(!; %5!/%(!/-(%(!2'% 2%(!/A;54/%!;52+='(;'45='4B)%:!50%(+CDC/4.%!(),2.4%).%(!D!';!,-(-'->4%!<;%4<;'%!B)-+4/4%11%!.%5-<<;1/2%F!''!%(+!4<,-.+;1+!/%!.%(,%5+%.!'%(!,-(-'->4%(F!!

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

(A;(,4.41%!/-4+!)+.%!)+4'4(2%!; %5!,.)/%15%!%1!5;(!/%!/23454+!%1!6')5-(%C7C8$-(,$;+%!92($=/.->21;(%:!5;.!/%(!/-(%(!2'% 2%(!/A;(,4.41%!-1+!,)!,.- -B)%.!/%(!$2<-'=(%(!J/%(+.)5+4-1!/%(!>'-+)'%(!.-)>%(,F!''!%(+!4<,-.+;1+!/%!.%(,%5+%.!'%(!,-(-'->4%(!J'4.%!;++%1+4 %<%1+!';!.)+.4B)%!-,-(-'->4%-!/%!';!1-+45%!/%! -+.%!<2/45;<%1+,F!.1!5;(!/%!/-)+%:!/%<;1/%&!'A; 4(!/%! -+.%!<2/%541!-)!/%! -+.%!,$;.<;54%1F!

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

9A;)+.%(!<2/45;<%1+(!,%) %1+!5-1+%14.!/%!'A;(,4.41%!-)!/%(!/2.4 2(!/%!5%++%!()+(+;15%F!.1!5;(!/A;((-54;+4-1:!4'!%(+!4<,-.+;1+!/A)+.%!+./(!;++%1+43!D!1%!,;(!/2,;((%.!'%(!/-(%(!<;%4<;'%(!B)-+4/4%11%(!.%5-<<;1/2%(!J5%''%(C54!(-1+!34%2%(!%1!3-15+4-1!/%!'041/45;+4-1!%+!/%!'00>%!/)!,;+4%1+,F!

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

1#.23(41('#3(12.!9.!(34'5.!6'527898!Z[[!<>!59\88'44954:!,-)/.%!,-).!(-')+4-1!+) ;+'%!%1!(;5$%+C/-(%!

1#.23(41('#3(12.!9.!(34'5.!6'527898!Z[[[!<>!19\(2.4:!,-)/.%!,-).!(-')+4-1!+) ;+'%!%1!(;5$%+C/-(%!

1#.23(41('#3(12.!9.!(34'5.!6'527898!]^[!<>!.5_152:!,-)/.%!,-).!(-')+4-1!+) ;+'%!%1!(;5$%+C/-(%!

1#.23(41('#3(12.!9.!(34'5.!6'527898!^[[!<>:!,-)/.%!,-).!(-')+4-1!+) ;+'%!%1!(;5$%+C/-(%!

1#'9.!1#.23(41('#3('`\.!A13.8!^[[!<>:!5-<,.4<2!1#'9.!1#.23(41('#3('`\.!A13.8!^[[!<>:!5-<,.4<2!D!5.-B)%.!!

1#2895:!5-<,.4<2!%33%. %(5%1+!!

1_.A83(:!5-<,.4<2!%33%. %(5%1+!!

1(6'48'8:!5-<,.4<2!%33%. %(5%1+!!

1(69#812'5.!1!(A148'8'5.:!5-<,.4<2!%33%. %(5%1+!(25;+'%!!

1(69C5.B8'295:!5-<,.4<2!1(C1!4.(2D.8!E]F!<>:!5-<,.4<2!%33%. %(5%1+!151#'5.:!5-<,.4<2!152148'8'5.:!5-<,.4<2!%33%. %(5%1+!!

152'68'88'5.!1!(A148'8'5.!.212!68'881(:!5-<,.4<2!

!1414152'5.!(F8F!][[!<>G]^!<>:!>2')'%!D!'4+2.;+4-1!,.-'-1>2%!

148.6'#!H^!<>:!,-)/.%!,-).!(-')+4-1!+) ;+'%!%1!(;5$%+C/-(%!

148.6'#!59\88'44954!Z[[!<>:!,-)/.%!,-).!(-')+4-1!+) ;+'%!%1!(;5$%+C/-(%!

148.6'#!.5_1524!]^[:!,-)/.%!,-).!(-')+4-1!+) ;+'%!%1!(;5$%+C/-(%!

148.6'#!^[[!<>:!,-)/.%!,-).!(-')+4-1!+) ;+'%!%1!(;5$%+C/-(%!

148.6'#!'5I.#21A(.!^[[!<>G^!<':!,-)/.%!%+!(-')+4-1!,-).!)(;>%!,;.%1+2.;'!

148.6'#!19\(2.4!Z[[[!<>:!,-)/.%!,-).!(-')+4-1!+) ;+'%!%1!(;5$%+C/-(%!

148.6'#!'5I.#21A(.!Z!>:!,-)/.%!%+!(-')+4-1!,-).!,.2,;.;+4-1!41*%5+;+'%!

148.6'#!#99.'5.:!,-)/.%!,-).!(-')+4-1!+) ;+'%!%1!(;5$%+C/-(%!

148'8156.!Z^[!<>!B'21J'5.!#:!,-)/.%!,-).!()(,%1(4-1!+) ;+'%!%1!(;5$%+!D!/%)%!5-<,;.+4<%1+(!!

148'8156.!E[[!<>!B'21J'5.!#:!,-)/.%!,-).!()(,%1(4-1!+) ;+'%!%1!(;5$%+!D!/%)%!5-<,;.+4<%1+(!!

148'8156.!^[[!<>!B'21J'5.!#:!,-)/.%!,-).!()(,%1(4-1!+) ;+'%!%1!(;5$%+!D!/%)%!5-<,;.+4<%1+(!!

148'8'5.!Z[[!<>!'51B1:!5-<,.4<2!,-).!(-')+4-1!+) ;+'%!148'8'5.!E][!<>!B'21J'5.!#!5'#79(14:!5-<,.4<2!%33%. %(5%1+!

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

925-1(%4''2%!925-1(%4''2%!925-1(%4''2%!925-1(%4''2%!!!!!D!,-(-'->4%!2'% 2%D!,-(-'->4%!2'% 2%D!,-(-'->4%!2'% 2%D!,-(-'->4%!2'% 2%!!!!

Page 10: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

!

Z[!

!

148'8'5.!EE[!<>!8!_!J.9'#1J.52:!5-<,.4<2!,-).!(-')+4-1!+) ;+'%!

148'8'5.!^[[!<>!'51B1:!5-<,.4<2!,-).!(-')+4-1!+) ;+'%!148'8'5.!^[[!<>!5'#79(14:!5-<,.4<2!148'8'5.!^[[!<>!B'21J'5.!#!9A.8('5:!5-<,.4<2!%33%. %(5%1+!(25;+'%!!

148'8'5.!#99.'5.!#1_.'5.!#998.8:!5-<,.4<2!148'8'5.!#99.'5.!6'_8.8!^[[!<>GZ[!<>:!5-<,.4<2!148'8'5.!9\!87K5.!^[[!<>:!5-<,.4<2!148'8'5.!9\!8795.!^[[!<>:!5-<,.4<2!D!5.-B)%.!148'8'5.!9\!8795.!B'21J'5.!#:!5-<,.4<2!%33%. %(5%1+!!

148'8'5.!(1_815!^[[!<>:!5-<,.4<2!148'8'5.!J.8#C!Z!>:!,-)/.%!,-).!(-')+4-1!+) ;+'%!148'8'5.!J.8#C!Z[[!<>:!,-)/.%!,-).!(-')+4-1!+) ;+'%!148'8'5.!J.8#C!]^[!<>:!,-)/.%!,-).!(-')+4-1!+) ;+'%!148'8'5.!J.8#C!^[[!<>:!,-)/.%!,-).!(-')+4-1!+) ;+'%!148'8'5.!J.8#C!J.9'#12'95!_1J'('1(.!^[[!<>:!5-<,.4<2!D!5.-B)%.!

148'8'5.!,7!L!^[[!<>:!5-<,.4<2!>;(+.-C.2(4(+;1+!148'8'5.!8'.88.!_1A8.!F[[!<>:!5-<,.4<2!%33%. %(5%1+!148'8'5.!8892.#2!E[[!<>:!5-<,.4<2!>;(+.-C.2(4(+;1+!148'8'5.!812'9!^[[!<>:!5-<,.4<2!148'8'5.!812'98718J!^[[!<>:!5-<,.4<2!(25;+'%!148'8'5.!8'#7189!^[[!<>:!5-<,.4<2!148'8'5.!49(\A(.!A9\#7181!8.#98912'!Z[[!<>:!,-)/.%!,-).!(-')+4-1!+) ;+'%!

148'8'5.!49(\A(.!A9\#7181!8.#98912'!Z[[[!<>:!,-)/.%!,-).!(-')+4-1!+) ;+'%!

148'8'5.!49(\A(.!A9\#7181!8.#98912'!]^[!<>:!,-)/.%!,-).!(-')+4-1!+) ;+'%!

148'8'5.!49(\A(.!A9\#7181!8.#98912'!^[[!<>:!,-)/.%!,-).!(-')+4-1!+) ;+'%!

148'8'5.!2.B1!^[[!<>:!5-<,.4<2!148'8'5.!27.818('M!]^[!<>:!,-)/.%!,-).!(-')+4-1!+) ;+'%!%1!(;5$%+!

148'8'5.!27.818('M!^[[!<>:!5-<,.4<2!D!5.-B)%.!148'8'5.!27.818('M!^[[!<>:!,-)/.%!,-).!(-')+4-1!+) ;+'%!%1!(;5$%+!

148'8'5.!\841!E]^!<>:!5-<,.4<2!%33%. %(5%1+!148'8'5.!\841!E]^!<>:!>2')'%!148'8'5.!\841!^[[!<>:!5-<,.4<2!%33%. %(5%1+!148'8'5.!\841!21J8955..!.__.8B.4#.52.!Z[[[!<>:!5-<,.4<2!%33%. %(5%1+!(25;+'%!

148'8'5.!\841!B'21J'5..!#!21J8955..!.__.8B.4#.52.:!5-<,.4<2!%33%. %(5%1+!(25;+'%!!

148'8'5.!B'21J'5..!AZ!#!9.89(:!5-<,.4<2!!

148'8'8718J:!5-<,.4<2!(-')+'%!%33%. %(5%1+!148'8'4\#8.!F[[!<>:!5-<,.4<2!D!5.-B)%.!1488199(:!5-<,.4<2!

!14889!E][!<>:!5-<,.4<2!14889!^[[!.__.8B.4#.52:!5-<,.4<2!%33%. %(5%1+!14889!^[[!<>!B'21J'5.!#!.__.8B.4#.52:!5-<,.4<2!%33%. %(5%1+!!

14889!^[[!<>!B'21J'5.!#:!,-)/.%!%33%. %(5%1+%!,-).!(-')+4-1!+) ;+'%!%1!(;5$%+C/-(%!!

14889!^[[!<>:!5-<,.4<2!14889!.__.8B.4#.52!E][!<>:!5-<,.4<2!%33%. %(5%1+!14889!.212!68'881(:!,-)/.%!%33%. %(5%1+%!,-).!(-')+4-1!+) ;+'%!%1!(;5$%+C/-(%!!

148891##.(:!5-<,.4<2!%33%. %(5%1+!(25;+'%!148891##.(:!5-<,.4<2!(25;+'%!A8'48.8!HL!<>:!5-<,.4<2!%33%. %(5%1+!#189'949(\8415!Z[[!<>:!,-)/.%!,-).!(-')+4-1!+) ;+'%!%1!(;5$%+C/-(%!

#121(6'5.![:]^[!>:!,-)/.%!-.;'%!#121(6'5.![:^!>!B'21J'5.!#:!,-)/.%!,-).!(-')+4-1!+) ;+'%!!

#121(6'5.!19\(2.4!Z!>:!,-)/.%!,-).!(-')+4-1!+) ;+'%!#121(6'5.!.5_1524!.2!59\88'44954![:Z[!>:!,-)/.%!,-).!(-')+4-1!+) ;+'%!

#121(6'5.!598J1(.![:^[!>:!,-)/.%!,-).!(-')+4-1!+) ;+'%!

#._1838'5.!^[[!<>:!,-)/.%!,-).!(-')+4-1!+) ;+'%!%1!(;5$%+C/-(%!

#.871(615:!,-)/.%!%33%. %(5%1+%!,-).!(-')+4-1!+) ;+'%!%1!(;5$%+!

#.873(:!5-<,.4<2!#7895148'8'5.!EE[!<>:!>2')'%!#(1816'5.!E[[!<>:!5-<,.4<2!#(1816'5.!E[[!<>:!5-<,.4<2!%33%. %(5%1+!#(1816'5.!^[[!<>:!5-<,.4<2!(-')+'%!%33%. %(5%1+!9.29M1(6'5.:!5-<,.4<2!%33%. %(5%1+!(25;+'%!!

99(.15!,7!L!^[[!<>:!5-<,.4<2!>;(+.-C.2(4(+;1+!_'5'99(:!5-<,.4<2!618148'8'5.!EE[!<>:!>2')'%!C189.6'#!H^!<>:!,-)/.%!,-).!(-')+4-1!+) ;+'%!%1!(;5$%+C/-(%!

C189.6'#!Z7[!<>:!,-)/.%!,-).!(-')+4-1!+) ;+'%!%1!(;5$%+!

C189.6'#!E[[!<>:!,-)/.%!,-).!(-')+4-1!+) ;+'%!%1!(;5$%+!

C189.6'#!^[[!<>G^!<':!,-)/.%!%+!(-' ;1+!,-).!(-')+4-1!41*%5+;+'%!

C189.6'#!^[[!<>G^!<':!,-)/.%!,-).!(-')+4-1!41*%5+;+'%!J.2148'8'5.!B'21J'5.!#:!5-<,.4<2!!

J.2148'8'5.:!5-<,.4<2!

Page 11: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

!

ZZ!

J'688'B:!,-)/.%!,-).!(-')+4-1!+) ;+'%!%1!(;5$%+!598'8'5.!B'#18'9:!5-<,.4<2!59B1#.29(!J148'8'5.!8181#.21J9(,:!5-<,.4<2!!

98152'5.!(F8F!][[!<>G]^!<>:!>2')'%!D!'4+2.;+4-1!,.-'-1>2%!

81359#'(!^[[!<>:!5-<,.4<2!D!()5%.!89(38'8'5.:!>2')'%!881B19\1(:!5-<,.4<2!41('8815!]!>:!,-)/.%!-.;'%!%1!(;5$%+C/-(%!4186.8'8'5.!]^[!<>:!5-<,.4<2!D!5.-B)%.!4186.8'8'5.!^[[!<>:!5-<,.4<2!D!5.-B)%.!4.9148'8:!5-<,.4<2!4.9951(6'5.:!5-<,.4<2!

49(J'5!E[[!<>:!5-<,.4<2!D!()5%.!%1!,';B)%++%!+$%.<-3-.<2%!

49(J'5!E[[!<>:!5-<,.4<2!D!()5%.!%1!+)+%!

49(\#.23(:!5-<,.4<2!%33%. %(5%1+!!

49(\8415!Z[[[!<>:!5-<,.4<2!%33%. %(5%1+!49(\8415!]^[!<>:!,-)/.%!%33%. %(5%1+%!,-).!(-')+4-1!+) ;+'%:!%1!(;5$%+!

49(\8415!EE[!<>:!5-<,.4<2!%33%. %(5%1+!49(\8415!^[[!<>:!5-<,.4<2!%33%. %(5%1+!49(\8415!59\88'44954!.2!.5_1524:!5-<,.4<2!%33%. %(5%1+!

2961(!E[[!<>:!5-<,.4<2!\841(6'5!^[[!<>:!5-<,.4<2!%33%. %(5%1+!\8418'5.!E]^!<>:!5-<,.4<2!%33%. %(5%1+!B.619.'5.!19\(2.4:!(),,-(4+-4.%!!

B'2168'88.:!>2')'%!!

!

#$%&!'%(!()*%+(!,-.+%).(!/0)1!/23454+!%1!6789:!/%(!5;(!/0$2<-'=(%!;4>)?!-1+!2+2!.;,,-.+2(!; %5!/%(!/-(%(!2'% 2%(!/A;54/%!;(5-.+4B)%:!50%(+CDC/4.%!(),2.4%).%(!D!Z!>.;<<%!,;.!*-).!5$%&!'A;/)'+%F!''!%(+!4<,-.+;1+!/%!.%(,%5+%.!'%(!,-(-'->4%(F!!

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

(;! 4+;<41%!#!/-4+!)+.%!)+4'4(2%!; %5!,.)/%15%!%1!5;(!/%!/23454+!%1!6')5-(%C7C8$-(,$;+%!92($=/.->21;(%:!5;.!/%(!/-(%(!2'% 2%(!/%! 4+;<41%!#:!5A%(+CDC/4.%!(),2.4%).%(!D!Z>!,;.!*-).!5$%&!'A;/)'+%:!-1+!,)!,.- -B)%.!/%(!$2<-'=(%(!J/%(+.)5+4-1!/%(!>'-+)'%(!.-)>%(,F!''!%(+!4<,-.+;1+!/%!.%(,%5+%.!'%(!,-(-'->4%(!J'4.%!;++%1+4 %<%1+!';!.)+.4B)%!-,-(-'->4%-!/%!';!1-+45%!/%! -+.%!<2/45;<%1+,F!.1!5;(!/%!/-)+%:!/%<;1/%&!'A; 4(!/%! -+.%!<2/%541!-)!/%! -+.%!,$;.<;54%1F!

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

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

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,1#'9.!14#98A'`\.!14818212.4!9.!892144'\J!.2!9.!J165.4'\J!1(8718J1:!>.;1)'2(!%1!(;5$%+C/-(%!1#2'!^:!(-')+4-1!+) ;+'%!%1!;<,-)'%!19.51!#!^[[!<>:!5-<,.4<2!%1.-+2!1_.A83(:!5-<,.4<2!%33%. %(5%1+!!

1(6'48'8:!5-<,.4<2!%33%. %(5%1+!!1(69#812'5.!1!(A148'8'5.:!5-<,.4<2!%33%. %(5%1+!(25;+'%!!

925-1(%4''2%!925-1(%4''2%!925-1(%4''2%!925-1(%4''2%!!!!!D!,-(-'->4%!2'% 2%D!,-(-'->4%!2'% 2%D!,-(-'->4%!2'% 2%D!,-(-'->4%!2'% 2%!!!!

Page 12: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

!

Z]!

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`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

Page 13: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

!

ZE!

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

!J'93!#1(#'\J!B'21J'5.!#:!5-<,.4<2!%33%. %(5%1+!J'93!B'21J'5.!#!Z[[[!.__.8B.4#.52.!4154!4\#8.:!,-)/.%!,-).!(-')+4-1!+) ;+'%!%1!(;5$%+!C!.1!5-).(!/A;..)+!/%!5-<<%.54;'4(;+4-1!J'93!B'21J'5.!#!Z[[[!<>:!,-)/.%!,-).!(-')+4-1!+) ;+'%!%1!(;5$%+C/-(%!C!.1!5-).(!/A;..)+!/%!5-<<%.54;'4(;+4-1!J'93!B'21J'5.!#!]^[!<>:!5-<,.4<2!D!5.-B)%.!J'93!B'21J'5.!#!^[[!<>:!5-<,.4<2!D!5.-B)%.!J9B'88.8:!,-)/.%!,-).!(-')+4-1!+) ;+'%!%1!(;5$%+!J'0;/<414(+.;+4-1!/%!5%++%!(,254;'4+2!5-1/)4+!D!'0;+(-.,+4-1!J'0;/<414(+.;+4-1!/%!5%++%!(,254;'4+2!5-1/)4+!D!'0;+(-.,+4-1!J'0;/<414(+.;+4-1!/%!5%++%!(,254;'4+2!5-1/)4+!D!'0;+(-.,+4-1!J'0;/<414(+.;+4-1!/%!5%++%!(,254;'4+2!5-1/)4+!D!'0;+(-.,+4-1!/0)1%!/-(%!/0;54/%!;(5-.+4B)%!2B)4 ;'%1+%!D!Z[!>:!';.>%<%1+!/0)1%!/-(%!/0;54/%!;(5-.+4B)%!2B)4 ;'%1+%!D!Z[!>:!';.>%<%1+!/0)1%!/-(%!/0;54/%!;(5-.+4B)%!2B)4 ;'%1+%!D!Z[!>:!';.>%<%1+!/0)1%!/-(%!/0;54/%!;(5-.+4B)%!2B)4 ;'%1+%!D!Z[!>:!';.>%<%1+!(),2.4%).%!D!';!'4<4+%!/%!(25).4+2!34%2%!D!Z!>!,;.!*-).!5$%&!(),2.4%).%!D!';!'4<4+%!/%!(25).4+2!34%2%!D!Z!>!,;.!*-).!5$%&!(),2.4%).%!D!';!'4<4+%!/%!(25).4+2!34%2%!D!Z!>!,;.!*-).!5$%&!(),2.4%).%!D!';!'4<4+%!/%!(25).4+2!34%2%!D!Z!>!,;.!*-).!5$%&!'0;/)'+%F!#%++%!(,254;'4+2!%(+!/-15!5-1+.%'0;/)'+%F!#%++%!(,254;'4+2!%(+!/-15!5-1+.%'0;/)'+%F!#%++%!(,254;'4+2!%(+!/-15!5-1+.%'0;/)'+%F!#%++%!(,254;'4+2!%(+!/-15!5-1+.%CCCC41/4B)2%!5$%&!'%!()*%+!41/4B)2%!5$%&!'%!()*%+!41/4B)2%!5$%&!'%!()*%+!41/4B)2%!5$%&!'%!()*%+!/23454+;4.%!%1!6789,/23454+;4.%!%1!6789,/23454+;4.%!%1!6789,/23454+;4.%!%1!6789,!J\(2'B'21J'5.4!A13.8!.5_1524:!5-<,.4<2!D!5.-B)%.!J\(2'B'21J'5.4!J.8#C:!5-<,.4<2!%33%. %(5%1+!J\(2'B'21J'5.4!89#7.!5'#79(14:!5-<,.4<2!%33%. %(5%1+!!J\(2'B'21J'5.4!\841:!5-<,.4<2!D!5.-B)%.!J\(2'B'21J'5.4!\841:!5-<,.4<2!%33%. %(5%1+!J\(2'B'21J'5.4!63.27!(.9.8(.:!5-<,.4<2!518A1(.C:!5-<,.4<2!%1.-+2!5'#988'B.:!5-<,.4<2!%1.-+2!987219'(:!(-')+4-1!+) ;+'%!%1!;<,-)'%!987219'(:!(-')+4-1!+) ;+'%!%1!(;5$%+!812.4!A1(41J'`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̀ \'5'5.!B'21J'5.!#!68159:!5-<,.4<2!%1.-+2!!̀ \92'B'2!9!.:!5-<,.4<2!,%''45)'2!8.99M95!Z!>!4154!4\#8.:!5-<,.4<2!%33%. %(5%1+!2/)'5-.2!D!'A;(,;.+;<!%+!;)!(-.+4+-'!8.99M95!^[[!<>!4154!4\#8.:!5-<,.4<2!D!5.-B)%.!8.5\283(!^[[:!2<)'(4-1!+) ;+'%!%1!+-4+%!8.B'21(94.:!>.;1)'2(!,-).!(-')+4-1!+) ;+'%!%1!(;5$%+C/-(%!8.B'21(94.:!(-')+4-1!+) ;+'%!87'51#23(:!,-)/.%!,-).!(-')+4-1!+) ;+'%!!

Page 14: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

!

ZF!

87'59_.A81(!B.8B.'5.!J'.(!#'2895:!,-)/.%!,-).!(-')+4-1!+) ;+'%!%1!(;5$%+C/-(%!!87'59_.A81(:!>2')'%!!8\29B'5#'5.:!5-<,.4<2!%1.-+2!4186.598!1!(1!B'21J'5.!#:!5-<,.4<2!D!5.-B)%.!4186.598!1!(1!B'21J'5.!#:!5-<,.4<2!%33%. %(5%1+!4186.598!1!(1!B'21J'5.!#:!(-')+4-1!+) ;+'%!%1!;<,-)'%!418B'2!1!(1!6(\#\8951J'9.:!5-<,.4<2!%33%. %(5%1+!418B'2!1!(1!(34'5.:!(-')+4-1!+) ;+'%!%1!;<,-)'%!/%!Z[!<'!418B'2!1!(1!(34'5.:!(-')+4-1!+) ;+'%!%1!;<,-)'%(!/%!^!<'!4.9951(6'5.:!5-<,.4<2!!49(\#.23(:!5-<,.4<2!%33%. %(5%1+!!49(\8\2'5.!8181B.8'5.:!5-<,.4<2!%1.-+2!49(\2'95!9A1#'9.!14#98A'`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`\.:!(-')+4-1!,-).!,%.3)(4-1!2921J'5.!#95#.528.:!(-')+4-1!,-).!,%.3)(4-1!2921J'5.!6(\#'9'`\.:!(-')+4-1!,-).!,%.3)(4-1!28'49(B'2:!(-')+4-1!+) ;+'%!%1!(;5$%+!289873415!(!6(\#'9'`\.!^[:!(-')+4-1!,-).!,%.3)(4-1!\B.42.89(!B'21J'5.!1F9F.F#F:!(-')+4-1!+) ;+'%!B14#9#'289(:!(-')+4-1!+) ;+'%!%1!;<,-)'%!B.6.21(!8'#7.(.2:!>.;1)'2(!,-).!(-')+4-1!+) ;+'%!%1!(;5$%+C/-(%!B.'59A'14.:!5-<,.4<2!%33%. %(5%1+!B.'594214.:!(-')+4-1!+) ;+'%:!;<,-)'%(!B.('2.5:!5-<,.4<2!,%''45)'2!B.('2.5:!>.;1)'2(!,-).!()(,%1(4-1!+) ;+'%!%1!(;5$%+!B.53(:!(-')+4-1!+) ;+'%!%1!;<,-)'%!B'5#'J1M!(!8:!5-<,.4<2!%1.-+2!D!'4+2.;+4-1!,.-'-1>2%!B'21#.J'(:!>.;1)'2!,-).!(-')+4-1!+) ;+'%!

B'2168'88.:!>2')'%!!B'21J'5.!#!Z!>!41\2.8:!5-<,.4<2!%33%. %(5%1+!B'21J'5.!#!Z[!89\8!#.52!16\.22152:!(-')+4-1!41*%5+;+'%!,-).!,%.3)(4-1!B'21J'5.!#!Z[[[!<>!'51B1:!>.;1)'2!%33%. %(5%1+!,-).!(-')+4-1!+) ;+'%!%1!(;5$%+!/-(%!B'21J'5.!#!Z[[[!<>!9A.8('5:!5-<,.4<2!%33%. %(5%1+!B'21J'5.!#!Z[[[!<>!41\2.8:!,-)/.%!-.;'%!%1!(;5$%+(!B'21J'5.!#!Z[[[!8'.88.!_1A8.!4152.:!,-)/.%!-.;'%!%1!(;5$%+(!B'21J'5.!#!^[[!<>!('871:!5-<,.4<2!B'21J'5.!#!^[[!<>!9A.8('5:!5-<,.4<2!D!5.-B)%.!B'21J'5.!#!^[[!<>!41\2.8:!5-<,.4<2!D!5.-B)%.!B'21J'5.!#!18896!Z!>:!5-<,.4<2!%33%. %(5%1+!B'21J'5.!#!A13.8!Z!>:!5-<,.4<2!%33%. %(5%1+!B'21J'5.!#!_1\8.!]!89\8!#.52:!5-''=.%!%1!(-')+4-1!B'21J'5.!#!J.8#C!Z!>:!5-<,.4<2!%33%. %(5%1+!B'21J'5.!#!9A.8('5!^[[!<>:!,-)/.%!,-).!(-')+4-1!+) ;+'%!%1!(;5$%+!B'21J'5.!#!41(B.8!^[[!<>:!5-<,.4<2!B'21J'5.!#!41\2.8!.5_1524!]^[!<>:!5-<,.4<2!D!5.-B)%.!B'21J'5.!#!41\2.8!4154!4\#8.!Z!>:!5-<,.4<2!%33%. %(5%1+!B'21J'5.!#!41\2.8!4154!4\#8.!Z[[[!<>:!,-)/.%!,-).!(-')+4-1!+) ;+'%!%1!(;5$%+!B'21J'5.!#!41\2.8!4154!4\#8.!^[[!<>:!5-<,.4<2!D!5.-B)%.!B'21J'5.!#!\841!Z[[[!<>:!,-)/.%!,-).!(-')+4-1!+) ;+'%!%1!(;5$%+C/-(%!B'21J'5.!#!\841!^[[!<>!3.)4+!%%-+4B)%:!5-<,.4<2!D!5.-B)%.!B'21J'5.!#!\841!^[[!<>:!5-<,.4<2!D!5.-B)%.!B'21J'5.!#!\841!.__.8B.4#.52.!Z[[[!<>:!5-<,.4<2!%33%. %(5%1+!B'21J'5.4!#:!A]:!(-')+4-1!+) ;+'%!B'214#98A9(!Z!>:!5-<,.4<2!%33%. %(5%1+!B'214#98A9(!Z!>:!>.;1)'2!,-).!(-')+4-1!+) ;+'%!%1!(;5$%+!B'214#98A9(!4154!4\#8.!.5_1524!][[!<>:!5-<,.4<2!D!5.-B)%.!2/)'5-.2!;)!(-.+4+-'!%+!D!';!(;55$;.41%!(-/4B)%!B'214#98A9(!4154!4\#8.!21J8955.!^[[!<>:!5-<,.4<2!D!5.-B)%.!2/)'5-.2!;)!(-.+4+-'!%+!D!'A;(,;.+;<!B'214#98A9(!49(\A(.!Z!>:!>.;1)'2!,-).!(-')+4-1!+) ;+'%!%1!(;5$%+C/-(%!B'214#98A9(!21J8955.!^[[!<>:!5-<,.4<2!B'2127'95:!>.;1)'2!%33%. %(5%1+!%1!(;5$%+C/-(%!B'B1J35.!19\(2.4:!5-<,.4<2!D!5.-B)%.!B'B1J35.!.5_1524:!5-<,.4<2!D!5.-B)%.!B'B1J35.!J\(2':!5-<,.4<2!%1.-+2!B'B1J35.!295'`\.:!5-<,.4<2!%33%. %(5%1+!B'B1J35.!295'`\.:!5-<,.4<2!%1.-+2!

Page 15: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

!

Z^!

(%!.%5-).(!D!)1%!;'+%.1;+4 %!+$2.;,%)+4B)%!%(+!4<,2.;+43F!

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

(A;54/%!1;'4/4%4B)%!1%!/-4+!,;(!)+.%!)+4'4(2!%1!5;(!/%!/23454+!%1!6789F!1)((4:! -)(!/% %&!;+(-')<%1+!413-.<%.! -+.%!<2/%541! -)(!/% %&!;+(-')<%1+!413-.<%.! -+.%!<2/%541! -)(!/% %&!;+(-')<%1+!413-.<%.! -+.%!<2/%541! -)(!/% %&!;+(-')<%1+!413-.<%.! -+.%!<2/%541!(4! -)(!J-)!)1!<%<+.%!/%! -+.%!3;<4''%,!)+%(!;++%41+!/A)1!/23454+!%1!6')5-(%C7C8$-(,$;+%!92($=/.->21;(%F!

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

(0;54/%!1;'4/4%4B)%!;,,;.+4%1+!D!';!3;<4''%!/%(!B)41-'-1%(N!4'!%%4(+%!/A;)+.%(!<-'25)'%(!/%!5%++%!3;<4''%!,-).!'%(B)%''%(!;)5)1!5;(!/A$2<-'=(%!1A;!2+2!.;,,-.+2!5$%&!/%(!()*%+(!/23454+;4.%(!%1!6789!N!5%,%1/;1+:!/)!3;4+!/%!'%).!;,,;.+%1;15%!D!5%++%!3;<4''%:!'%).!,.%(5.4,+4-1!5$%&!5%(!,;+4%1+(!/% .;!,.%1/.%!%1!5-<,+%!5%!.4(B)%F!

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

5.681J!7!89\8!#.52:!()(,%1(4-1!+) ;+'%! 5.681J!_982.!19\(2.4:!5-<,.4<2!(25;+'%!

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

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

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

''!%(+!4<,-.+;1+!/%!,.2 %14.! -+.%!<2/%541!(4! -)(!J-)!)1!<%<+.%!/%! -+.%!3;<4''%,!)+%(!;++%41+!/A)1!/23454+!%1!6')5-(%C7C8$-(,$;+%!92($=/.->21;(%!5;.!)1!.4(B)%!/A$2<-'=(%!J/%(+.)5+4-1!/%(!>'-+)'%(!.-)>%(,!%%4(+%!; %5!/A;)+.%(!<2/45;<%1+(!/%!';!<)<%!3;<4''%!B)%!'A;54/%!,4,2<4/4B)%F!!

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

(0;54/%!,4,2<4/4B)%!;,,;.+4%1+!D!';!3;<4''%!/%(!B)41-'-1%(F!(%(!;'+%.1;+4 %(!+$2.;,%)+4B)%(!;)!(%41!/%!5%++%!3;<4''%!1%!(-1+!,;(!+-+;'%<%1+!%%%<,+%(!/A)1!.4(B)%!/A$2<-'=(%!5$%&!'%(!()*%+(!/23454+;4.%(!%1!6789F!

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

1#'9.!8'8.J'9'`\.!A'961(.5'`\.!F[[!<>:!5-<,.4<2!,%''45)'2!

1#'9.!8'8.J'9'`\.!886!F[[!<>:!5-<,.4<2!%1.-+2!

8'881J!_982!F[[!<>:!5-<,.4<2!%1.-+2!

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

#-1+.%#-1+.%#-1+.%#-1+.%CCCC41/4B)2%41/4B)2%41/4B)2%41/4B)2%!!!!

925-1(%4''2%!J(;)3!(4+);+4-1!,;.+45)'4/.%,!925-1(%4''2%!J(;)3!(4+);+4-1!,;.+45)'4/.%,!925-1(%4''2%!J(;)3!(4+);+4-1!,;.+45)'4/.%,!925-1(%4''2%!J(;)3!(4+);+4-1!,;.+45)'4/.%,!%1!.;4(-1!/%!'0;,,;.+%1;15%!D!)1%!%1!.;4(-1!/%!'0;,,;.+%1;15%!D!)1%!%1!.;4(-1!/%!'0;,,;.+%1;15%!D!)1%!%1!.;4(-1!/%!'0;,,;.+%1;15%!D!)1%!3;<4''%!,$;.<;5-'->4B)%!D!.4(B)%3;<4''%!,$;.<;5-'->4B)%!D!.4(B)%3;<4''%!,$;.<;5-'->4B)%!D!.4(B)%3;<4''%!,$;.<;5-'->4B)%!D!.4(B)%!!!!

Page 16: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

!

Z7!

925-1(%4''2%!925-1(%4''2%!925-1(%4''2%!925-1(%4''2%!!!!!D!,-(-'->4%!2'% 2%D!,-(-'->4%!2'% 2%D!,-(-'->4%!2'% 2%D!,-(-'->4%!2'% 2%!!!!

#$%&!'%(!()*%+(!,-.+%).(!/0)1!/23454+!%1!6789:!/%(!5;(!/0$2<-'=(%!;4>)?!-1+!2+2!.;,,-.+2(!; %5!/%(!/-(%(!2'% 2%(!/A;54/%!;52+='(;'45='4B)%!%+!/%!,;.;52+;<-':!50%(+CDC/4.%!(),2.4%).%(!;)%!,-(-'->4%(!<;%4<;'%(!B)-+4/4%11%(!.%5-<<;1/2%(F!''!%(+!4<,-.+;1+!/%!.%(,%5+%.!'%(!,-(-'->4%(F!!

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

(%!+21-.4';+%!/-4+!)+.%!)+4'4(2!; %5!,.)/%15%!%1!5;(!/%!/23454+!%1!6')5-(%C7C8$-(,$;+%!92($=/.->21;(%:!5;.!/%(!/-(%(!2'% 2%(!/A;(,4.41%!%+!/%!,;.;52+;<-'!-1+!,)!,.- -B)%.!/%(!$2<-'=(%(!J/%(+.)5+4-1!/%(!>'-+)'%(!.-)>%(,F!''!%(+!4<,-.+;1+!/%!.%(,%5+%.!'%(!,-(-'->4%(!J'4.%!;++%1+4 %<%1+!';!.)+.4B)%!-,-(-'->4%-!/%!';!1-+45%!/%! -+.%!<2/45;<%1+,F!.1!5;(!/%!/-)+%:!/%<;1/%&!'A; 4(!/%! -+.%!<2/%541!-)!/%! -+.%!,$;.<;54%1F!

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

(%!+21-.4';+%!%(+!)1!/2.4 2!/)!,;.;52+;<-'!%+!/%!'A;(,4.41%!N!/A;)+.%(!<2/45;<%1+(!%1!5-1+4%11%1+:!4'!%(+!/-15!4<,-.+;1+!/A)+.%!+./(!;++%1+43!D!1%!,;(!/2,;((%.!'%(!/-(%(!<;%4<;'%(!B)-+4/4%11%(!.%5-<<;1/2%(!%1!5;(!/A;((-54;+4-1F!

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

(9561(6'#!Z!>:!,-)/.%!-.;'%!%1!(;5$%+! 41('8815!]>:!,-)/.%!-.;'%!%1!(;5$%+C/-(%!!

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!!!!!/%(!/-112%(!/4(,-14+'%(!/%(!/-112%(!/4(,-14+'%(!/%(!/-112%(!/4(,-14+'%(!/%(!/-112%(!/4(,-14+'%(!!!!!

J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!!!!

(;!,.4(%!/%!5%!<2/45;<%1+!,;.! -4%!+)55;'%!-)!-,$+;'<4B)%!%(+!,-((4+'%F!

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

1!5%!*-).:!4'!10%%4(+%!,;(!/%!.4(B)%!$2<-'=+4B)%!4/%1+4342!5$%&!'%(!()*%+(!/23454%1+(!%1!6789!,-).!'%!+'%)!/%!<2+$='/1%!;/<414(+.2!,;.! -4%!+)55;'%!-)!-,$+;'<4B)%F!!

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

152'4.82'`\.!#1(J152.!,-<<;/%!-,$+;'<4B)%!#9((\!4.#:!5-<,.4<2!%1.-+2!D!()5%.!#9((\A(.\!]FF]!89\8!#.52:!5-'')+-4.%!9\(#'A(.\:!5-''=.%!8142'((.4!J95(.95:!,0+%!D!()5%.!!87.53(.878'5.!A(.\!9.!J.273(.5.!4J'27C('5.!

A..#71J!4152.!.2!736'.5.![FZ^SG[F[]S:!5-''=.%!%1!(-')+4-1!

4#18(.5.![FZ]!89\8!#.52:!5-''=.%!%1!.254,4%1+!)14/-(%!42'((1:!5-''=.%!B'21A(.\![FZ!89\8!#.52:!5-''=.%!

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

(;!,.4(%!/%!5%!<2/45;<%1+!,;.! -4%!+)55;'%!-)!-,$+;'<4B)%!%(+!,-((4+'%F!

Page 17: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

!

ZH!

\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!!!!!

/%(!/-112%(!/4(,-14+'%(!/%(!/-112%(!/4(,-14+'%(!/%(!/-112%(!/4(,-14+'%(!/%(!/-112%(!/4(,-14+'%(!!!!!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!!!!

(;!,.4(%!/%!5%!<2/45;<%1+!%(+!,-((4+'%F!

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

1!5%!*-).:!4'!10%%4(+%!,;(!/%!.4(B)%!$2<-'=+4B)%!4/%1+4342!5$%&!'%(!()*%+(!/23454%1+(!%1!6789!,-).!';!+),4 ;5;T1%F!!

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

A\8'_9815![:]^!89\8!#.52!JZ]:^!<>G^!<',!198.51('5.!ZG][[![[[:!(-')+4-1!41*%5+;+'%!

A\8'_9815![:]^!89\8!#.52!J]^!<>GZ[!<',!198.51('5.!ZG][[![[[:!(-')+4-1!41*%5+;+'%!

A\8'_9815![:]^!89\8!#.52:!(-')+4-1!41*%5+;+'%!%1!;<,-)'%!

A\8'_9815![:^[!89\8!#.52:!(-')+4-1!41*%5+;+'%!%1!;<,-)'%!

A\8'_9815!198.51('5.![:^[!89\8!#.52!J]^!<>G^!<',:!(-')+4-1!41*%5+;+'%!%1!;<,-)'%!!

A\8'_9815!198.51('5.![:^[!89\8!#.52!J^[!<>GZ[!<',:!(-')+4-1!41*%5+;+'%!%1!;<,-)'%!!!

A\8'B1#1'5.!16\.22152![:^[S:!(-')+4-1!41*%5+;+'%!%1!3';5-1!

A\8'B1#1'5.!198.51('5.!`\1('J.9!J]^!<>GZ[!<',:!(-')+4-1!41*%5+;+'%!

A\8'B1#1'5.!198.51('5.!`\1('J.9!J^[!<>GZ[!<',:!(-')+4-1!41*%5+;+'%!%1!;<,-)'%!

A\8'B1#1'5.!16\.22152![:]^S!198.51('5.:!(-')+4-1!41*%5+;+'%!%1!3';5-1!

A\8'B1#1'5.!16\.22152![:]^S:!(-')+4-1!41*%5+;+'%!%1!3';5-1!

A\8'B1#1'5.!16\.22152![:^[S!198.51('5.:!(-')+4-1!41*%5+;+'%!%1!3';5-1!

A\8'B1#1'5.!A!A81\5![:]^S!J]:^!<>G<',:!(-')+4-1!41*%5+;+'%!

A\8'B1#1'5.!A!A81\5![:^[S!J^!<>G<',:!(-')+4-1!41*%5+;+'%!

A\8'B1#1'5.!J.8#C![:]^S!J^[!<>G][!<',:!(-')+4-1!

41*%5+;+'%!%1!3';5-1!A\8'B1#1'5.!J.8#C![:^[S!JZ[[!<>G][!<',:!(-')+4-1!41*%5+;+'%!%1!3';5-1!

A\8'B1#1'5.!J.8#C!][!<>GF!<':!(-')+4-1!41*%5+;+'%!,-).! -4%!41+.;.;5$4/4%11%!%1!;<,-)'%!

A\8'B1#1'5.!89\8!81#7'15.427.4'.!16\.22152!^!<>G!<':!(-')+4-1!41*%5+;+'%!J -4%!41+.;.;5$4/4%11%,!

#7(98739812.!9.!A\8'B1#1'5.!91C921!8718J!Z[[!<>G][!<':!(-')+4-1!41*%5+;+'%!J[:^S,!%1!;<,-)'%!

#7(98739812.!9.!A\8'B1#1'5.!91C921!8718J!Z]:^!<>G!^!<':!(-')+4-1!41*%5+;+'%!J[:]^S,!%1!;<,-)'%!

#7(98739812.!9.!A\8'B1#1'5.!91C921!8718J!]^!<>G!Z[!<':!(-')+4-1!41*%5+;+'%!J[:]^S,!%1!;<,-)'%!

#7(98739812.!9.!A\8'B1#1'5.!91C921!8718J!]^!<>G^!<':!(-')+4-1!41*%5+;+'%!J[:^S,!%1!;<,-)'%!

#7(98739812.!9.!A\8'B1#1'5.!91C921!8718J!^[!<>GZ[!<':!(-')+4-1!41*%5+;+'%!J[:^S,!%1!;<,-)'%!

#7(98739812.!9.!A\8'B1#1'5.!91C921!8718J!^[!<>G][!<':!(-')+4-1!41*%5+;+'%!J[:]^S,!%1!;<,-)'%!

J18#1'5.![:]^!S!J^[<>G][<(,!198.51('5.:!(-')+4-1!41*%5+;+'%!

J18#1'5.![:]^!S!J^[<>G][<(,:!(-')+4-1!41*%5+;+'%!J18#1'5.![:^[!S!JZ[[<>G][<(,!198.51('5.:!(-')+4-1!41*%5+;+'%!

J18#1'5.![:^[!S!JZ[[<>G][<(,:!(-')+4-1!41*%5+;+'%!J18#1'5.!81#7'15.427.4'.:!(-')+4-1!41*%5+;+'%!J -4%!41+.;C.;5$4/4%11%,!

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

(;!,.4(%!/%!5%!<2/45;<%1+!%(+!,-((4+'%F!

Page 18: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

!

ZL!

925-1(%4''2%!925-1(%4''2%!925-1(%4''2%!925-1(%4''2%!!!!!D!,-(-'->4%!2'% 2%D!,-(-'->4%!2'% 2%D!,-(-'->4%!2'% 2%D!,-(-'->4%!2'% 2%!!!!

#$%&!'%(!()*%+(!,-.+%).(!/0)1!/23454+!%1!6789:!/%(!5;(!/0$2<-'=(%!;4>)?!-1+!2+2!.;,,-.+2(!; %5!/%(!/-(%(!2'% 2%(!/A;54/%!;52+='(;'45='4B)%:!50%(+CDC/4.%!(),2.4%).%(!D!';!,-(-'->4%!<;%4<;'%!B)-+4/4%11%!.%5-<<;1/2%F!''!%(+!4<,-.+;1+!/%!.%(,%5+%.!'%(!,-(-'->4%(F!!

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

(%!5;.+;(;';+%!5;'54B)%!%(+!)1!/2.4 2!/%!'A;(,4.41%F!9A;)+.%(!<2/45;<%1+(!%1!5-1+4%11%1+:!4'!%(+!/-15!4<,-.+;1+!/A)+.%!+./(!;++%1+43!D!1%!,;(!/2,;((%.!'%(!/-(%(!<;%4<;'%(!B)-+4/4%11%(!.%5-<<;1/2%(!%1!5;(!/A;((-54;+4-1F!

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

A8'48.8!HL!<>:!5-<,.4<2!%33%. %(5%1+!#.871(615:!,-)/.%!%33%. %(5%1+%!,-).!(-')+4-1!+) ;+'%!%1!(;5$%+!!

49(\8415!Z[[[!<>:!5-<,.4<2!%33%. %(5%1+!49(\8415!]^[!<>:!,-)/.%!%33%. %(5%1+%!,-).!(-')+4-1!+) ;+'%:!%1!(;5$%+!

49(\8415!EE[!<>:!5-<,.4<2!%33%. %(5%1+!49(\8415!^[[!<>:!5-<,.4<2!%33%. %(5%1+!49(\8415!59\88'44954!.2!.5_1524:!5-<,.4<2!%33%. %(5%1+!

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

(%!5;.+;(;';+%!5;'54B)%!/-4+!)+.%!)+4'4(2!; %5!,.)/%15%!%1!5;(!/%!/23454+!%1!6')5-(%C7C8$-(,$;+%!92($=/.->21;(%:!5;.!/%(!/-(%(!2'% 2%(!/A;(,4.41%!-1+!,)!,.- -B)%.!/%(!$2<-'=(%(!J/%(+.)5+4-1!/%(!>'-+)'%(!.-)>%(,F!''!%(+!4<,-.+;1+!/%!.%(,%5+%.!'%(!,-(-'->4%(!J'4.%!;++%1+4 %<%1+!';!.)+.4B)%!-,-(-'->4%-!/%!';!1-+45%!/%! -+.%!<2/45;<%1+,F!.1!5;(!/%!/-)+%:!/%<;1/%&!'A; 4(!/%! -+.%!<2/%541!-)!/%! -+.%!,$;.<;54%1F!

925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!,;.+45)'4/.%,!%1!.;4(-1!/%!,;.+45)'4/.%,!%1!.;4(-1!/%!,;.+45)'4/.%,!%1!.;4(-1!/%!,;.+45)'4/.%,!%1!.;4(-1!/%!

'0;,,;.+%1;15%!D!)1%!5';((%!'0;,,;.+%1;15%!D!)1%!5';((%!'0;,,;.+%1;15%!D!)1%!5';((%!'0;,,;.+%1;15%!D!)1%!5';((%!,$;.<;5-'->4B)%!D!.4(B)%,$;.<;5-'->4B)%!D!.4(B)%,$;.<;5-'->4B)%!D!.4(B)%,$;.<;5-'->4B)%!D!.4(B)%!!!!

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

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

(%!5;.+)+;<4/%!;,,;.+4%1+!D!';!5';((%!/%(!()'3;<4/%(!$=,->'=52<4;1+(F!(%(!;'+%.1;+4 %(!+$2.;,%)+4B)%(!;)!(%41!/%!5%++%!5';((%!1%!(-1+!,;(!+-+;'%<%1+!%%%<,+%(!/A)1!.4(B)%!/A$2<-'=(%!5$%&!'%(!()*%+(!/23454+;4.%(!%1!6789F!

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

6(\#'9981(!^[[!<>:!5-<,.4<2!(25;+'%! !

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

''!%(+!4<,-.+;1+!/%!,.2 %14.! -+.%!<2/%541!(4! -)(!J-)!)1!<%<+.%!/%! -+.%!3;<4''%,!)+%(!;++%41+!/A)1!/23454+!%1!6')5-(%C7C8$-(,$;+%!92($=/.->21;(%!5;.!)1!.4(B)%!/A$2<-'=(%!J/%(+.)5+4-1!/%(!>'-+)'%(!.-)>%(,!%%4(+%!; %5!/A;)+.%(!<2/45;<%1+(!/%!';!<)<%!5';((%!B)%!'%!5;.+)+;<4/%F!

Page 19: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

!

Z"!

\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!!!!!

J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!!!!

(;!,.4(%!/%!5%!<2/45;<%1+!,;.! -4%!-,$+;'<4B)%!%(+!,-((4+'%F!

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

1!5%!*-).:!4'!10%%4(+%!,;(!/%!.4(B)%!$2<-'=+4B)%!4/%1+4342!5$%&!'%(!()*%+(!/23454%1+(!%1!6789!,-).!'%(!(,254;'4+2(!5-1+%1;1+!/)!5$'-.;<,$2145-'!;/<414(+.2%(!,;.! -4%!-,$+;'<4B)%F!!

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

#.A.9.M1#9(:!!,-)/.%!%+!(-')+4-1!,-).!5-''=.%!%1!(-')+4-1!#.A.5'#9(![:F!89\8!#.52:!'=-,$4'4(;+!%+!(-')+4-1!,-).!5-''=.%!!!

#.A.5'#9(!Z!89\8!#.52:!,-<<;/%!-,$+;'<4B)%!!!

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

(;!,.4(%!/%!5%!<2/45;<%1+!,;.! -4%!-,$+;'<4B)%!%(+!,-((4+'%F!

925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!

,;.+45)'4/.%,!%1!.;4(-1!/%!5;(!-+(%. 2(!,;.+45)'4/.%,!%1!.;4(-1!/%!5;(!-+(%. 2(!,;.+45)'4/.%,!%1!.;4(-1!/%!5;(!-+(%. 2(!,;.+45)'4/.%,!%1!.;4(-1!/%!5;(!-+(%. 2(!/A$2<-'=(%!;4>)?/A$2<-'=(%!;4>)?/A$2<-'=(%!;4>)?/A$2<-'=(%!;4>)?!!!!

9%(!5;(!4(-'2(!/A$2<-'=(%!41+.; ;(5)';4.%!-1+!2+2!.;,,-.+2(!5$%&!/%(!,;+4%1+(!/23454+;4.%(!%1!6789!.%5% ;1+!/%!';!5$'-.-B)41%F!.1!5-1(2B)%15%:!';!5$'-.-B)41%!(%.;!)+4'4(2%!; %5!,.25;)+4-1!5$%&!5%(!,;+4%1+(F!!

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

(;!5$'-.-B)41%!;,,;.+4%1+!D!';!5';((%!/%(!;<41-CFCB)41-'241%(F!

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

5'B1`\'5.!Z[[!<>:!5-<,.4<2!(25;+'%!5'B1`\'5.!]^!<>G^!<':!(4.-,!5'B1`\'5.!E[[!<>:!5-<,.4<2!,%''45)'2!

5'B1`\'5.!^[!<>G<':!(-')+4-1!41*%5+;+'%!5981(\:!>2')'%!J5-1+4%1+!2>;'%<%1+!/)!,.->);14',!41B18'5.:!5-<,.4<2!,%''45)'2!

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

B-)(!/% %&!413-.<%.! -+.%!<2/%541!(4! -)(!J-)!)1!<%<+.%!/%! -+.%!3;<4''%,!)+%(!;++%41+!/A)1!/23454+!%1!6')5-(%C7C8$-(,$;+%!92($=/.->21;(%!5;.!)1!.4(B)%!/A$2<-'=(%!J/%(+.)5+4-1!/%(!>'-+)'%(!.-)>%(,!%%4(+%!; %5!';!5$'-.-B)41%F!

Page 20: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

!

][!

925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!,;.+45)'4/.%,!%1!.;4(-1!/%!5;(!-+(%. 2(!,;.+45)'4/.%,!%1!.;4(-1!/%!5;(!-+(%. 2(!,;.+45)'4/.%,!%1!.;4(-1!/%!5;(!-+(%. 2(!,;.+45)'4/.%,!%1!.;4(-1!/%!5;(!-+(%. 2(!

/A$2<-'=(%!;4>)?/A$2<-'=(%!;4>)?/A$2<-'=(%!;4>)?/A$2<-'=(%!;4>)?!!!!

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

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

(;!54,.-3'-%;541%!;,,;.+4%1+!D!';!3;<4''%!/%(!B)41-'-1%(F!(%(!;'+%.1;+4 %(!+$2.;,%)+4B)%(!;)!(%41!/%!5%++%!3;<4''%!1%!(-1+!,;(!+-+;'%<%1+!%%%<,+%(!/A)1!.4(B)%!/A$2<-'=(%!5$%&!'%(!()*%+(!/23454+;4.%(!%1!6789F!

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

15_1(9M3(!]^[!<>:!5-<,.4<2!,%''45)'2! 15_1(9M3(!^[[!<>:!5-<,.4<2!,%''45)'2!(25;+'%! #'_(9M!][[!<>GZ[[!<':!(-')+4-1!41*%5+;+'%!,-).!,%.3)(4-1!

J'B,! #'_(9M!][[!<>GZ[[!<':!(-')+4-1!,-).!,%.3)(4-1!%1!,-5$%! #'_(9M!]^[!<>:!5-<,.4<2!,%''45)'2! #'_(9M!]^[!<>G^!<':!>.;1)'2(!%+!(-')+4-1!,-).!

()(,%1(4-1!+) ;+'%! #'_(9M!F[[!<>G][[!<':!(-')+4-1!41*%5+;+'%!,-).!,%.3)(4-1!

J'B,! #'_(9M!F[[!<>G][[!<':!(-')+4-1!,-).!,%.3)(4-1!%1!,-5$%! #'_(9M!^[[!<>:!5-<,.4<2!,%''45)'2!(25;+'%! #'_(9M!^[[!<>G^!<':!>.;1)'2(!%+!(-')+4-1!,-).!

()(,%1(4-1!+) ;+'%! #'_(9M!H^[!<>:!5-<,.4<2!,%''45)'2! #'889A.82!][[!<>GZ[[!<':!(-')+4-1!,-).!,%.3)(4-1! #'889A.82!F[[!<>G][[!<':!(-')+4-1!,-).!,%.3)(4-1! #'889_(9M1#'5.!16\.22152!][[!<>GZ[[!<':!(-')+4-1!

,-).!,%.3)(4-1! #'889_(9M1#'5.!16\.22152!F[[!<>G][[!<':!(-')+4-1!

,-).!,%.3)(4-1! #'889_(9M1#'5.!1(J\4!]^[!<>:!5-<,.4<2!,%''45)'2! #'889_(9M1#'5.!1(J\4!^[[!<>:!5-<,.4<2!,%''45)'2! #'889_(9M1#'5.!1(2.8!]^[!<>:!5-<,.4<2!,%''45)'2! #'889_(9M1#'5.!1(2.8!^[[!<>:!5-<,.4<2!,%''45)'2! #'889_(9M1#'5.!1(2.8!H^[!<>:!5-<,.4<2!,%''45)'2! #'889_(9M1#'5.!18896!]^[!<>:!5-<,.4<2!,%''45)'2! #'889_(9M1#'5.!18896!^[[!<>:!5-<,.4<2!,%''45)'2! #'889_(9M1#'5.!18896!H^[!<>:!5-<,.4<2!,%''45)'2! #'889_(9M1#'5.!18896!6.5.8'`\.4!]^[!<>:!

5-<,.4<2!,%''45)'2! #'889_(9M1#'5.!18896!6.5.8'`\.4!^[[!<>:!

5-<,.4<2!,%''45)'2! #'889_(9M1#'5.!18896!6.5.8'`\.4!H^[!<>:!

5-<,.4<2!,%''45)'2!

#'889_(9M1#'5.!A'961815!]^[!<>:!5-<,.4<2!,%''45)'2! #'889_(9M1#'5.!A'961815!^[[!<>:!5-<,.4<2!,%''45)'2!

(25;+'%! #'889_(9M1#'5.!A'961815!H^[!<>:!5-<,.4<2!,%''45)'2! #'889_(9M1#'5.!#284!]^[!<>:!5-<,.4<2!,%''45)'2! #'889_(9M1#'5.!#284!H^[!<>:!5-<,.4<2!,%''45)'2! #'889_(9M1#'5.!91C921!8718J!][[!<>GZ[[!<':!

(-')+4-1!,-).!,%.3)(4-1! #'889_(9M1#'5.!91C921!8718J!]^[!<>:!5-<,.4<2!

,%''45)'2! #'889_(9M1#'5.!91C921!8718J!F[[!<>G][[!<':!

(-')+4-1!,-).!,%.3)(4-1! #'889_(9M1#'5.!91C921!8718J!^[[!<>:!5-<,.4<2!

,%''45)'2!(25;+'%! #'889_(9M1#'5.!91C921!8718J!H^[!<>:!5-<,.4<2!

,%''45)'2! #'889_(9M1#'5.!.6!]^[!<>:!5-<,.4<2!,%''45)'2! #'889_(9M1#'5.!.6!^[[!<>:!5-<,.4<2!,%''45)'2! #'889_(9M1#'5.!.6!H^[!<>:!5-<,.4<2!,%''45)'2! #'889_(9M1#'5.!6!61J!]^[!<>:!5-<,.4<2!,%''45)'2!

(25;+'%! #'889_(9M1#'5.!6!61J!^[[!<>:!5-<,.4<2!,%''45)'2!

(25;+'%! #'889_(9M1#'5.!6!61J!H^[!<>:!5-<,.4<2!,%''45)'2!

(25;+'%! #'889_(9M1#'5.!'B1M!]^[!<>:!5-<,.4<2!,%''45)'2! #'889_(9M1#'5.!'B1M!^[[!<>:!5-<,.4<2!,%''45)'2!

(25;+'%! #'889_(9M1#'5.!'B1M!H^[!<>:!5-<,.4<2!,%''45)'2! #'889_(9M1#'5.!J.8#C!][[!<>GZ[[!<':!(-')+4-1!,-).!

,%.3)(4-1! #'889_(9M1#'5.!J.8#C!]^[!<>:!5-<,.4<2!,%''45)'2! #'889_(9M1#'5.!J.8#C!F[[!<>G][[!<':!(-')+4-1!,-).!

,%.3)(4-1! #'889_(9M1#'5.!J.8#C!^[[!<>:!5-<,.4<2!,%''45)'2!

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

B-)(!/% %&!413-.<%.! -+.%!<2/%541!(4! -)(!J-)!)1!<%<+.%!/%! -+.%!3;<4''%,!)+%(!;++%41+!/A)1!/23454+!%1!6')5-(%C7C8$-(,$;+%!92($=/.->21;(%!5;.!)1!.4(B)%!/A$2<-'=(%!J/%(+.)5+4-1!/%(!>'-+)'%(!.-)>%(,!%%4(+%!; %5!';!54,.-3'-%;541%!;/<414(+.2%!,;.! -4%!-.;'%!-)!41*%5+;+'%F!

Page 21: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

!

]Z!

(25;+'%! #'889_(9M1#'5.!J.8#C!H^[!<>:!5-<,.4<2!,%''45)'2! #'889_(9M1#'5.!8158718J1!][[!<>GZ[[!<':!(-')+4-1!

,-).!,%.3)(4-1! #'889_(9M1#'5.!8158718J1!F[[!<>G][[!<':!(-')+4-1!

,-).!,%.3)(4-1! #'889_(9M1#'5.!8158718J1!^[[!<>:!5-<,.4<2!

,%''45)'2! #'889_(9M1#'5.!`\1('J.9!][[!<>GZ[[!<':!(-')+4-1!

,-).!,%.3)(4-1!%1!,-5$%! #'889_(9M1#'5.!`\1('J.9!]^[!<>:!5-<,.4<2!,%''45)'2! #'889_(9M1#'5.!`\1('J.9!^[[!<>:!5-<,.4<2!,%''45)'2!

(25;+'%! #'889_(9M1#'5.!`\1('J.9!H^[!<>:!5-<,.4<2!,%''45)'2! #'889_(9M1#'5.!815A1M3!]^[!<>:!5-<,.4<2!,%''45)'2! #'889_(9M1#'5.!81JA1M3!^[[!<>:!5-<,.4<2!,%''45)'2! #'889_(9M1#'5.!812'98718J!]^[!<>:!5-<,.4<2!

,%''45)'2! #'889_(9M1#'5.!812'98718J!^[[!<>:!5-<,.4<2!

,%''45)'2!(25;+'%! #'889_(9M1#'5.!886!]^[!<>:!5-<,.4<2!,%''45)'2! #'889_(9M1#'5.!886!^[[!<>:!5-<,.4<2!,%''45)'2!

(25;+'%!

#'889_(9M1#'5.!886!H^[!<>:!5-<,.4<2!,%''45)'2! #'889_(9M1#'5.!41599D!]^[!<>:!5-<,.4<2!,%''45)'2! #'889_(9M1#'5.!41599D!^[[!<>:!5-<,.4<2!,%''45)'2!

(25;+'%! #'889_(9M1#'5.!41599D!H^[!<>:!5-<,.4<2!,%''45)'2! #'889_(9M1#'5.!2.B1!]^[!<>:!5-<,.4<2!,%''45)'2!

(25;+'%! #'889_(9M1#'5.!2.B1!^[[!<>:!5-<,.4<2!,%''45)'2!

(25;+'%! #'889_(9M1#'5.!2.B1!H^[!<>:!5-<,.4<2!,%''45)'2! #'889_(9M1#'5.!6'527898!]^[!<>:!5-<,.4<2!,%''45)'2! #'889_(9M1#'5.!6'527898!^[[!<>:!5-<,.4<2!,%''45)'2!

(25;+'%! #'889_(9M1#'5.!6'527898!H^[!<>:!5-<,.4<2!,%''45)'2! #'889_(9M1#'5.!D39\4!]^[!<>:!5-<,.4<2!,%''45)'2! #'889_(9M1#'5.!D39\4!^[[!<>:!5-<,.4<2!,%''45)'2!

(25;+'%! #'889_(9M1#'5.!D39\4!H^[!<>:!5-<,.4<2!,%''45)'2! \5'_(9M:!5-<,.4<2!,%''45)'2!(25;+'%!

\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!!!!!

J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!!!!

(;!,.4(%!/%!5%!<2/45;<%1+!,;.! -4%!-,$+;'<4B)%!-)!;).45)';4.%!%(+!,-((4+'%F!

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

1!5%!*-).:!4'!10%%4(+%!,;(!/%!.4(B)%!$2<-'=+4B)%!4/%1+4342!5$%&!'%(!()*%+(!/23454%1+(!%1!6789!,-).!'%(!(,254;'4+2(!5-1+%1;1+!!/%!';!54,.-3'-%;541%!;/<414(+.2%(!,;.! -4%!-,$+;'<4B)%!-)!;).45)';4.%F!

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

#'(9M15![:E!S:!,-<<;/%!-,$+;'<4B)%!#'(9M15![:E!89\8!#.52:!5-''=.%!#'(9M15!E!<>G<':!(-')+4-1!,-).!41(+4'';+4-1!;).45)';4.%!

#'889_(9M1#'5.!1(#95![:E!S:!5-''=.%!#'889M'51!][!<>GZ[[!<>:!()(,%1(4-1!,-).!41(+4'';+4-1!;).45)';4.%!

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

(;!,.4(%!/%!5%!<2/45;<%1+!,;.! -4%!-,$+;'<4B)%!-)!;).45)';4.%!%(+!,-((4+'%F!

Page 22: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

!

]]!

\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!

/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!!!!!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!!!!

(;!,.4(%!/%!5%!<2/45;<%1+!%(+!,-((4+'%F!

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

1!5%!*-).:!4'!10%%4(+%!,;(!/%!.4(B)%!$2<-'=+4B)%!4/%1+4342!5$%&!'%(!()*%+(!/23454%1+(!%1!6789!,-).!';!5-'5$4541%F!!

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

#9(#7'#'5.!989#1(#'\J!Z!<>:!5-<,.4<2!! #9(#7'J1M:!5-<,.4<2!,%''45)'2!!

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

(;!,.4(%!/%!5%!<2/45;<%1+!%(+!,-((4+'%F!

#-1+.%#-1+.%#-1+.%#-1+.%CCCC41/4B)2%41/4B)2%41/4B)2%41/4B)2%!!!!

(%!.%5-).(!D!)1%!;'+%.1;+4 %!+$2.;,%)+4B)%!%(+!4<,2.;+43F!

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

4;1(!-+*%+!

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

9'4\(95.:!5-<,.4<2!(25;+'%!

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

(;!/;,(-1%!1%!/-4+!,;(!)+.%!)+4'4(2%!%1!5;(!/%!/23454+!%1!6789F!1)((4:! -)(!/% %&!;+(-')<%1+!413-.<%.! -+.%!<2/%541! -)(!/% %&!;+(-')<%1+!413-.<%.! -+.%!<2/%541! -)(!/% %&!;+(-')<%1+!413-.<%.! -+.%!<2/%541! -)(!/% %&!;+(-')<%1+!413-.<%.! -+.%!<2/%541!(4! -)(!J-)!)1!<%<+.%!/%! -+.%!3;<4''%,!)+%(!;++%41+!/A)1!/23454+!%1!6')5-(%C7C8$-(,$;+%!92($=/.->21;(%F!

Page 23: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

!

]E!

\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!

/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!!!!!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!!!!!

(;!,.4(%!/%!5%!<2/45;<%1+!%(+!,-((4+'%F!

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

1!5%!*-).:!4'!10%%4(+%!,;(!/%!.4(B)%!$2<-'=+4B)%!4/%1+4342!5$%&!'%(!()*%+(!/23454%1+(!%1!6789!,-).!'%(!(,254;'4+2(!5-1+%1;1+!/%!';!/4$=/.-B)414/41%F!!

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

4.8.#98!E[[!<>:!>2')'%!D!'4+2.;+4-1!,.-'-1>2%!

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

(;!,.4(%!/%!5%!<2/45;<%1+!%(+!,-((4+'%F!

\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!!!!!

J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!!!!!

(;!,.4(%!/%!5%!<2/45;<%1+!,;.! -4%!'-5;'%!%(+!,-((4+'%F!

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

1!5%!*-).:!4'!10%%4(+%!,;(!/%!.4(B)%!$2<-'=+4B)%!4/%1+4342!5$%&!'%(!()*%+(!/23454%1+(!%1!6789!,-).!'%(!(,254;'4+2(!5-1+%1;1+!/%!';!/42+$=';<41%!;/<414(+.2%(!,;.! -4%!'-5;'%F!!

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

1(6.41(!A1\J.:!5./<%!!!1(6.41(!4\81#2'B.:!5./<%!!!1(6'5'#:!5./<%!9'#(9_.51#!499'`\.!#'A1!6.'63!Z!89\8!#.52:!>%'!9'#(9_.51#!499'`\.!D3J1:!>%'!%1!3';5-1!,.%(().4(2!8.818'(:!>%'!,-).!;,,'45;+4-1!'-5;'%!!!

281\J1(63(:!5./<%!!!B9(91(!Z!89\8!#.52:!>%'!,-).!;,,'45;+4-1!5)+;12%!B9(218.51#2'69!Z!89\8!#.52:!>%'!B9(218.5.!.J\(6.(!ZS:!>%'!B9(218.5.!.J\(6.(!ZS:!>%'!%1!3';5-1!,.%(().4(2!

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

(;!,.4(%!/%!5%!<2/45;<%1+!!,;.! -4%!'-5;'%!%(+!,-((4+'%F!

Page 24: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

!

]F!

\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!

/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!!!!!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!!!!!

(;!,.4(%!/%!5%!<2/45;<%1+!%(+!,-((4+'%F!

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

1!5%!*-).:!4'!10%%4(+%!,;(!/%!.4(B)%!$2<-'=+4B)%!4/%1+4342!5$%&!'%(!()*%+(!/23454%1+(!%1!6789!,-).!'%(!(,254;'4+2(!5-1+%1;1+!/)!/4<%1$=/.41;+%F!

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

#(98151\2'5.!^[!<>:!5-<,.4<2!B);/.4(25;+'%!!!981J1J'5.!^[!<>:!5-<,.4<2!,%''45)'2!B);/.4(25;+'%!!J.8#1(J:!5-<,.4<2!,%''45)'2!(25;+'%!!

51\4'#1(J!19\(2.4!^[!<>:!>2')'%!!51\4'#1(J:!(4.-,!!

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

(;!,.4(%!/%!5%!<2/45;<%1+!%(+!,-((4+'%F!

925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!

,;.+45)'4/.%,!%1!.;4(-1!/%!5;(!-+(%. 2(!,;.+45)'4/.%,!%1!.;4(-1!/%!5;(!-+(%. 2(!,;.+45)'4/.%,!%1!.;4(-1!/%!5;(!-+(%. 2(!,;.+45)'4/.%,!%1!.;4(-1!/%!5;(!-+(%. 2(!/A$2<-'=(%!;4>)?/A$2<-'=(%!;4>)?/A$2<-'=(%!;4>)?/A$2<-'=(%!;4>)?!!!!

#$%&!'%(!()*%+(!,-.+%).(!/0)1!/23454+!%1&=<;+4B)%!%1!6789:!/%(!5;(!/0$2<-'=(%!;4>)?!-1+!2+2!.;,,-.+2(!; %5!'%!/4<%.5;,.-'F!4-1!;/<414(+.;+4-1!/% .;!(%!3;4.%!(-)(!5-1+.U'%!<2/45;'!%+!';!(). %1)%!/0)1%!$2<-'=(%!2 %1+)%''%!/% .;!)+.%!/2,4(+2%F!

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

4;1(!-+*%+!

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

AF1F(F:!(-')+4-1!41*%5+;+'%!'FJF!

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

B-)(!/% %&!413-.<%.! -+.%!<2/%541!(4! -)(!J-)!)1!<%<+.%!/%! -+.%!3;<4''%,!)+%(!;++%41+!/A)1!/23454+!%1!6')5-(%C7C8$-(,$;+%!92($=/.->21;(%!5;.!)1!.4(B)%!/A$2<-'=(%!J/%(+.)5+4-1!/%(!>'-+)'%(!.-)>%(,!%%4(+%!; %5!'%!/4<%.5;,.-'F!

Page 25: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

!

]^!

\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!

/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!!!!!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!!!!!

(;!,.4(%!/%!5%!<2/45;<%1+!%(+!,-((4+'%F!

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

1!5%!*-).:!4'!10%%4(+%!,;(!/%!.4(B)%!$2<-'=+4B)%!4/%1+4342!5$%&!'%(!()*%+(!/23454%1+(!%1!6789!,-).!'%(!(,254;'4+2(!5-1+%1;1+!/%!';!/-%-.)+4541%F!

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

198'A(142'5.!Z[!<>:!'=-,$4'4(;+!,-).!)(;>%!,;.%1+2.;'!J,%.3)(4-1,!%1!3';5-1!

198'A(142'5.!Z[!<>G^!<':!(-')+4-1!41*%5+;+'%!,-).!,%.3)(4-1!%1!3';5-1!

198'A(142'5.!][!<>:!'=-,$4'4(;+!,-).!)(;>%!,;.%1+2.;'!J,%.3)(4-1,!%1!3';5-1!

198'A(142'5.!][!<>GZ[!<':!(-')+4-1!41*%5+;+'%!,-).!,%.3)(4-1!%1!3';5-1!

198'A(142'5.!Z^[!<>:!'=-,$4'4(;+!JD!/4((-')+4-1!.;,4/%,!,-).!)(;>%!,;.%1+2.;'!%1!3';5-1!

198'A(142'5.!^[!<>:!'=-,$4'4(;+!,-).!)(;>%!,;.%1+2.;'!J,%.3)(4-1,!%1!3';5-1!!

198'A(142'5.!^[!<>G]^!<':!(-')+4-1!41*%5+;+'%!,-).!,%.3)(4-1!%1!3';5-1!

198'A(142'5.!][[<>GZ[[<':!(-')+4-1!41*%5+;+'%!,-).!,%.3)(4-1!%1!3';5-1!

#1.(3M!]!<>G<'!(-')+4-1!D!/4')%.!,-).!,%.3)(4-1!!#7(98739812.!9.!99M98\A'#'5.!91C921!8718J!Z[!<>:!'=-,$4'4(;+!,-).!)(;>%!,;.%1+2.;'!%1!3';5-1!!

#7(98739812.!9.!99M98\A'#'5.!91C921!8718J!^[!<>:!'=-,$4'4(;+!,-).!)(;>%!,;.%1+2.;'!%1!3';5-1!!

99M98\A'#'5.!#7(98739812.!8'.88.!_1A8.!

J.9'#1J.52!Z[!<>:!'=-,$4'4(;+!,-).!)(;>%!,;.%1+2.;'!99M98\A'#'5.!#7(98739812.!8'.88.!_1A8.!J.9'#1J.52!Z^[!<>:!'=-,$4'4(;+!,-).!)(;>%!,;.%1+2.;'!

99M98\A'#'5.!#7(98739812.!8'.88.!_1A8.!J.9'#1J.52!][!<>:!'=-,$4'4(;+!,-).!)(;>%!,;.%1+2.;'!

99M98\A'#'5.!#7(98739812.!8'.88.!_1A8.!J.9'#1J.52!^[!<>:!'=-,$4'4(;+!,-).!)(;>%!,;.%1+2.;'!

99M98\A'#'5.!.A.6.!]!<>G<':!(-')+4-1!,-).!,%.3)(4-1!99M98\A'#'5.!.6!]!<>G<':!(-')+4-1!,-).!,%.3)(4-1!99M98\A'#'5.!6!61J!Z[!<>G^!<':!(-')+4-1!41*%5+;+'%!,-).!,%.3)(4-1!

99M98\A'#'5.!6!61J!]!<>G<':!(-')+4-1!41*%5+;+'%!,-).!,%.3)(4-1!

99M98\A'#'5.!2.B1!Z[!<>G^!<':!(-')+4-1!41*%5+;+'%!!99M98\A'#'5.!2.B1!][!<>GZ[!<':!(-')+4-1!41*%5+;+'%!99M98\A'#'5.!2.B1!][[!<>GZ[[!<':!(-')+4-1!41*%5+;+'%!!99M98\A'#'5.!2.B1!^[!<>G]^!<':!(-')+4-1!41*%5+;+'%!!J39#.2!^[!<>:!,-)/.%!%+!,.2C<2';1>%(!,-).!(-')+4-1!D!/4')%.!,-).!/4(,%.(4-1!'4,-(-<;'%!,-).!,%.3)(4-1!!!

4158\A'5.!Z[!<>:!,-)/.%!,-).!(-')+4-1!,-).!,%.3)(4-1!4158\A'5.!^[!<>:!,-)/.%!,-).!(-')+4-1!,-).!,%.3)(4-1!!!

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

(;!,.4(%!/%!5%!<2/45;<%1+!%(+!,-((4+'%F!

Page 26: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

!

]7!

\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!

/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!!!!!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!!!!!

15M'.2\J:!5-<,.4<2!()+'41>);'!!A98'8718J!5VE:!>.;1)'2(!99('8.(1M:!5-<,.4<2!()+'41>);'!!99('4.91(:!5-<,.4<2!()+'41>);'!!99('281B.(:!5-<,.4<2!()+'41>);'!!_98J\(.!9.!(A1AA.!#71\8'28.!5VH:!(-')+4-1!+) ;+'%!J>-)++%(,!

79J.9994.!5VZ:!(-')+4-1!J>-)++%(,!(!H]:!(-')+4-1!+) ;+'%!%1!>-)++%(!!(9A.('1!#9J8(.M.!5VHF:!(-')+4-1!+) ;+'%!5.\89#35.4'5.:!5-<,.4<2!8144'_(981!#9J894.!A9'895:!(-')+4-1!+) ;+'%!J>-)++%(,!

8144'_(981!#9J894.!A9'895:!>.;1)'2!

8144'_(981!#9J894.!A9'895:!5-<,.4<2!8144'_(981!#9J894.!99('494:!(-')+4-1!+) ;+'%:!>-)++%(!

8144'_(981!#9J894.!99('494:!5-<,.4<2!8144'_(981!#9J894.!99('494:!>.;1)'%(!49(\998:!(-')+4-1!+) ;+'%!J>-)++%(,!21A1#\J!#9J894.!A9'895:!5-<,.4<2!21A1#\J!#9J894.!A9'895:!>.;1)'%(!21A1#\J!#9J894.!A9'895:!(-')+4-1!+) ;+'%!J>-)++%(,!21A1#\J!#9J894.!99('494:!5-<,.4<2!21A1#\J!#9J894.!99('494:!(-')+4-1!+) ;+'%!J>-)++%(,!218152\(1!(.75'56!#9J8(.M.!5VHZ:!(-')+4-1!+) ;+'%!B'5'#189!1\!#14#18'((1:!(-')+4-1!+) ;+'%!!D.51('1:!5-<,.4<2!()+'41>);'!

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!,;.+45)'4/.%,!%1!.;4(-1!/%!,;.+45)'4/.%,!%1!.;4(-1!/%!,;.+45)'4/.%,!%1!.;4(-1!/%!,;.+45)'4/.%,!%1!.;4(-1!/%!

'A;,,;.+%1;15%!D!)1%!3;<4''%!!'A;,,;.+%1;15%!D!)1%!3;<4''%!!'A;,,;.+%1;15%!D!)1%!3;<4''%!!'A;,,;.+%1;15%!D!)1%!3;<4''%!!,$;.<;5-'->4B)%!D!.4(B)%,$;.<;5-'->4B)%!D!.4(B)%,$;.<;5-'->4B)%!D!.4(B)%,$;.<;5-'->4B)%!D!.4(B)%!!!!

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

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

(021-%;541%!;,,;.+4%1+!D!';!3;<4''%!/%(!B)41-'-1%(F!(%(!;'+%.1;+4 %(!+$2.;,%)+4B)%(!;)!(%41!/%!5%++%!3;<4''%!1%!(-1+!,;(!+-+;'%<%1+!%%%<,+%(!/A)1!.4(B)%!/A$2<-'=(%!5$%&!'%(!()*%+(!/23454+;4.%(!%1!6789F!

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

.59M1#'5.!8718J.M98!][[!<>:!5-<,.4<2!%1.-+2! .59M98!][[!<>:!5-<,.4<2!,%''45)'2!

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

''!%(+!4<,-.+;1+!/%!,.2 %14.! -+.%!<2/%541!(4! -)(!J-)!)1!<%<+.%!/%! -+.%!3;<4''%,!)+%(!;++%41+!/A)1!/23454+!%1!6')5-(%C7C8$-(,$;+%!92($=/.->21;(%!5;.!)1!.4(B)%!/A$2<-'=(%!J/%(+.)5+4-1!/%(!>'-+)'%(!.-)>%(,!%%4(+%!; %5!/A;)+.%(!<2/45;<%1+(!/%!';!<)<%!3;<4''%!B)%!'A21-%;541%F!

(;!,.4(%!/%!5%!<2/45;<%1+!%(+!,-((4+'%F!

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

1!5%!*-).:!4'!10%%4(+%!,;(!/%!.4(B)%!$2<-'=+4B)%!4/%1+4342!5$%&!'%(!()*%+(!/23454%1+(!%1!6789!,-).!'%(!(,254;'4+2(!5-1+%1;1+!/%!';!3/ %!/%!4;41+!'>1;5%F!

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

(;!,.4(%!/%!5%!<2/45;<%1+!%(+!,-((4+'%F!

Page 27: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

!

]H!

925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!,;.+45)'4/.%,!%1!.;4(-1!/%!,;.+45)'4/.%,!%1!.;4(-1!/%!,;.+45)'4/.%,!%1!.;4(-1!/%!,;.+45)'4/.%,!%1!.;4(-1!/%!

'A;,,;.+%1;15%!D!)1%!3;<4''%!!'A;,,;.+%1;15%!D!)1%!3;<4''%!!'A;,,;.+%1;15%!D!)1%!3;<4''%!!'A;,,;.+%1;15%!D!)1%!3;<4''%!!,$;.<;5-'->4B)%!D!.4(B)%,$;.<;5-'->4B)%!D!.4(B)%,$;.<;5-'->4B)%!D!.4(B)%,$;.<;5-'->4B)%!D!.4(B)%!!!!

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

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

(;!3')<2B)41%!;,,;.+4%1+!D!';!3;<4''%!/%(!B)41-'-1%(F!(%(!;'+%.1;+4 %(!+$2.;,%)+4B)%(!;)!(%41!/%!5%++%!3;<4''%!1%!(-1+!,;(!+-+;'%<%1+!%%%<,+%(!/A)1!.4(B)%!/A$2<-'=(%!5$%&!'%(!()*%+(!/23454+;4.%(!%1!6789F!

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

18\895.:!5-<,.4<2!

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

''!%(+!4<,-.+;1+!/%!,.2 %14.! -+.%!<2/%541!(4! -)(!J-)!)1!<%<+.%!/%! -+.%!3;<4''%,!)+%(!;++%41+!/A)1!/23454+!%1!6')5-(%C7C8$-(,$;+%!92($=/.->21;(%!5;.!)1!.4(B)%!/A$2<-'=(%!J/%(+.)5+4-1!/%(!>'-+)'%(!.-)>%(,!%%4(+%!; %5!/A;)+.%(!<2/45;<%1+(!/%!';!<)<%!3;<4''%!B)%!';!3')<2B)41%F!

925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!

,;.+45)'4/.%,!%1!.;4(-1!/%!5;(!-+(%. 2(!,;.+45)'4/.%,!%1!.;4(-1!/%!5;(!-+(%. 2(!,;.+45)'4/.%,!%1!.;4(-1!/%!5;(!-+(%. 2(!,;.+45)'4/.%,!%1!.;4(-1!/%!5;(!-+(%. 2(!/A$2<-'=(%!;4>)?/A$2<-'=(%!;4>)?/A$2<-'=(%!;4>)?/A$2<-'=(%!;4>)?!!!!

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

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

(%!>'4+%15';<4/%!;,,;.+4%1+!D!';!5';((%!/%(!()'3;<4/%(!$=,->'=52<4;1+(F!(%(!;'+%.1;+4 %(!+$2.;,%)+4B)%(!;)!(%41!/%!5%++%!5';((%!1%!(-1+!,;(!+-+;'%<%1+!%%%<,+%(!/A)1!.4(B)%!/A$2<-'=(%!5$%&!'%(!()*%+(!/23454+;4.%(!%1!6789F!

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

9195'(!^!<>:!5-<,.4<2!(25;+'%!9195'(!_1'A(.!Z:]^!<>:!5-<,.4<2!.\6(\#15!^!<>:!5-<,.4<2!(25;+'%!6('A.5#(1J'9.!A'961815!]:^!<>:!5-<,.4<2!(25;+'%!

6('A.5#(1J'9.!A'961815!^!<>:!5-<,.4<2!(25;+'%!6('A.5#(1J'9.!J.8#C!]:^!<>:!5-<,.4<2!(25;+'%!6('A.5#(1J'9.!J.8#C!^!<>:!5-<,.4<2!(25;+'%!6('A.5#(1J'9.!815A1M3!^!<>:!5-<,.4<2!(25;+'%!

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

B-)(!/% %&!413-.<%.! -+.%!<2/%541!(4! -)(!J-)!)1!<%<+.%!/%! -+.%!3;<4''%,!)+%(!;++%41+!/A)1!/23454+!%1!6')5-(%C7C8$-(,$;+%!92($=/.->21;(%!5;.!)1!.4(B)%!/A$2<-'=(%!J/%(+.)5+4-1!/%(!>'-+)'%(!.-)>%(,!%%4(+%!; %5!'%!>'4+%15';<4/%F!

Page 28: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

!

]L!

6('A.5#(1J'9.!815A1M3!]:^!<>:!5-<,.4<2!(25;+'%!6('A.5#(1J'9.!41599D!]:^!<>:!5-<,.4<2!(25;+'%!6('A.5#(1J'9.!41599D!^!<>:!5-<,.4<2!(25;+'%!6('A.5#(1J'9.!2.B1!]:^!<>:!5-<,.4<2!(25;+'%!6('A.5#(1J'9.!2.B1!^!<>:!5-<,.4<2!(25;+'%!6(\#9B15#.!^[[!<>G]:^!<>:!5-<,.4<2!,%''45)'2!6(\#9B15#.!^[[!<>G^!<>:!5-<,.4<2!,%''45)'2!6(\8'19!^[[!<>G]:^!<>:!5-<,.4<2!,%''45)'2!6(\8'19!^[[!<>G^!<>:!5-<,.4<2!,%''45)'2!

7.J'C9195'(!]:^!<>:!5-<,.4<2!(25;+'%!J.2_98J'5.!6('A.5#(1J'9.!J.8#C!4152.!^[[!<>G]:^!<>:!5-<,.4<2!,%''45)'2!

J.2_98J'5.!6('A.5#(1J'9.!J.8#C!4152.!^[[!<>G^!<>:!5-<,.4<2!,%''45)'2!

J'6(\#15!]:^!<>:!5-<,.4<2!(25;+'%!!

925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!,;.+45)'4/.%,!%1!.;4(-1!/%!,;.+45)'4/.%,!%1!.;4(-1!/%!,;.+45)'4/.%,!%1!.;4(-1!/%!,;.+45)'4/.%,!%1!.;4(-1!/%!

'A;,,;.+%1;15%!D!)1%!5';((%!'A;,,;.+%1;15%!D!)1%!5';((%!'A;,,;.+%1;15%!D!)1%!5';((%!'A;,,;.+%1;15%!D!)1%!5';((%!,$;.<;5-'->4B)%!D!.4(B)%,$;.<;5-'->4B)%!D!.4(B)%,$;.<;5-'->4B)%!D!.4(B)%,$;.<;5-'->4B)%!D!.4(B)%!!!!

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

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

(%(!;'+%.1;+4 %(!+$2.;,%)+4B)%(!;)!(%41!/%!5%++%!5';((%!1%!(-1+!,;(!+-+;'%<%1+!%%%<,+%(!/A)1!.4(B)%!/A$2<-'=(%!5$%&!'%(!()*%+(!/23454+;4.%(!%1!6789F!

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

6(\28'(!]^!<>:!5-<,.4<2!(25;+'%!

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

''!%(+!4<,-.+;1+!/%!,.2 %14.! -+.%!<2/%541!(4! -)(!J-)!)1!<%<+.%!/%! -+.%!3;<4''%,!)+%(!;++%41+!/A)1!/23454+!%1!6')5-(%C7C8$-(,$;+%!92($=/.->21;(%!5;.!)1!.4(B)%!/A$2<-'=(%!J/%(+.)5+4-1!/%(!>'-+)'%(!.-)>%(,!%%4(+%!; %5!/A;)+.%(!<2/45;<%1+(!/%!';!<)<%!5';((%!B)%!'%!>'4+-.1).4/%F!

Page 29: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

!

]"!

925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!,;.+45)'4/.%,!%1!.;4(-1!/%!,;.+45)'4/.%,!%1!.;4(-1!/%!,;.+45)'4/.%,!%1!.;4(-1!/%!,;.+45)'4/.%,!%1!.;4(-1!/%!

'A;,,;.+%1;15%!D!)1%!5';((%!'A;,,;.+%1;15%!D!)1%!5';((%!'A;,,;.+%1;15%!D!)1%!5';((%!'A;,,;.+%1;15%!D!)1%!5';((%!,$;.<;5-'->4B)%!D!.4(B)%,$;.<;5-'->4B)%!D!.4(B)%,$;.<;5-'->4B)%!D!.4(B)%,$;.<;5-'->4B)%!D!.4(B)%!!!!

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

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

(%(!;'+%.1;+4 %(!+$2.;,%)+4B)%(!;)!(%41!/%!5%++%!5';((%!1%!(-1+!,;(!+-+;'%<%1+!%%%<,+%(!/A)1!.4(B)%!/A$2<-'=(%!5$%&!'%(!()*%+(!/23454+;4.%(!%1!6789F!

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

9'1J'#895!E[!<>:!5-<,.4<2!D!'4+2.;+4-1!<-/4342%!9'1J'#895!L[!<>:!5-<,.4<2!(25;+'%!6('#1B.5'!L[!<>:!5-<,.4<2!(25;+'%!6('#(1D'9.!1(J\4!L[!<>:!5-<,.4<2!(25;+'%!6('#(1D'9.!1(2.8!L[!<>:!5-<,.4<2!(25;+'%!6('#(1D'9.!18896!L[!<>:!5-<,.4<2!(25;+'%!6('#(1D'9.!A'961815!L[!<>:!5-<,.4<2!(25;+'%!6('#(1D'9.!9#'!8718J1!L[!<>:!5-<,.4<2!(25;+'%!6('#(1D'9.!.6!L[!<>:!5-<,.4<2!(25;+'%!6('#(1D'9.!6!61J!L[!<>:!5-<,.4<2!(25;+'%!6('#(1D'9.!'B1M!L[!<>:!5-<,.4<2!(25;+'%!6('#(1D'9.!J.8#C!L[!<>:!5-<,.4<2!(25;+'%!6('#(1D'9.!8718J15\'!L[!<>:!5-<,.4<2!(25;+'%!

6('#(1D'9.!8'.88.!_1A8.!L[!<>:!5-<,.4<2!(25;+'%!6('#(1D'9.!`\1('J.9!L[!<>:!5-<,.4<2!(25;+'%!6('#(1D'9.!812'98718J!L[!<>:!5-<,.4<2!(25;+'%!6('#(1D'9.!886!L[!<>:!5-<,.4<2!(25;+'%!6('#(1D'9.!41599D!L[!<>:!5-<,.4<2!(25;+'%!6('#(1D'9.!4.8B'.8!E[!<>:!5-<,.4<2!D!'4+2.;+4-1!<-/4342%!

6('#(1D'9.!2.B1!L[!<>:!5-<,.4<2!(25;+'%!6('#(1D'9.!298(15!L[!<>:!5-<,.4<2!(25;+'%!6('#(1D'9.!6'527898!L[!<>:!5-<,.4<2!(25;+'%!6('#(1D'9.!D39\4!L[!<>:!5-<,.4<2!(25;+'%!6(3#9598!L[!<>:!5-<,.4<2!(25;+'%!!

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

''!%(+!4<,-.+;1+!/%!,.2 %14.! -+.%!<2/%541!(4! -)(!J-)!)1!<%<+.%!/%! -+.%!3;<4''%,!)+%(!;++%41+!/A)1!/23454+!%1!6')5-(%C7C8$-(,$;+%!92($=/.->21;(%!5;.!)1!.4(B)%!/A$2<-'=(%!J/%(+.)5+4-1!/%(!>'-+)'%(!.-)>%(,!%%4(+%!; %5!/A;)+.%(!<2/45;<%1+(!/%!';!<)<%!5';((%!B)%!'%!>'45';&4/%F!

925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!,;.+45)'4/.%,!%1!.;4(-1!/%!,;.+45)'4/.%,!%1!.;4(-1!/%!,;.+45)'4/.%,!%1!.;4(-1!/%!,;.+45)'4/.%,!%1!.;4(-1!/%!

'0;,,;.+%1;15%!D!)1%!5';((%!'0;,,;.+%1;15%!D!)1%!5';((%!'0;,,;.+%1;15%!D!)1%!5';((%!'0;,,;.+%1;15%!D!)1%!5';((%!,$;.<;5-'->4B)%!D!.4(B)%!,$;.<;5-'->4B)%!D!.4(B)%!,$;.<;5-'->4B)%!D!.4(B)%!,$;.<;5-'->4B)%!D!.4(B)%!!!!!

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

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

''!%(+!4<,-.+;1+!/%!,.2 %14.! -+.%!<2/%541!(4! -)(!J-)!)1!<%<+.%!/%! -+.%!3;<4''%,!)+%(!;++%41+!/A)1!/23454+!%1!6')5-(%C7C8$-(,$;+%!92($=/.->21;(%!5;.!)1!.4(B)%!/A$2<-'=(%!J/%(+.)5+4-1!/%(!>'-+)'%(!.-)>%(,!%%4(+%!; %5!/A;)+.%(!<2/45;<%1+(!/%!';!<)<%!5';((%!B)%!'%!>'4<2,4.4/%F!

Page 30: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

!

E[!

(%(!;'+%.1;+4 %(!+$2.;,%)+4B)%(!;)!(%41!/%!5%++%!5';((%!1%!(-1+!,;(!+-+;'%<%1+!%%%<,+%(!/A)1!.4(B)%!/A$2<-'=(%!5$%&!'%(!()*%+(!/23454+;4.%(!%1!6789F!

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

1J18.(!Z!<>:!5-<,.4<2!1J18.(!]!<>:!5-<,.4<2!1J18.(!E!<>:!5-<,.4<2!1J18.(!F!<>:!5-<,.4<2!1J18.(!7!<>:!5-<,.4<2!159'441!Z!<>:!5-<,.4<2!159'441!]!<>:!5-<,.4<2!159'441!E!<>:!5-<,.4<2!159'441!F!<>:!5-<,.4<2!159'441!7!<>:!5-<,.4<2!1B16('J!F!<>GF!<>:!5-<,.4<2!,%''45)'2!1B16('J!L!<>GF!<>:!5-<,.4<2!,%''45)'2!6('J.8'8'9.!1(J\4!Z!<>:!5-<,.4<2!6('J.8'8'9.!1(J\4!]!<>:!5-<,.4<2!6('J.8'8'9.!1(J\4!E!<>:!5-<,.4<2!6('J.8'8'9.!1(J\4!F!<>:!5-<,.4<2!6('J.8'8'9.!1(2.8!Z!<>:!5-<,.4<2!6('J.8'8'9.!1(2.8!]!<>:!5-<,.4<2!6('J.8'8'9.!1(2.8!E!<>:!5-<,.4<2!6('J.8'8'9.!1(2.8!F!<>:!5-<,.4<2!6('J.8'8'9.!18896!Z!<>:!5-<,.4<2!6('J.8'8'9.!18896!]!<>:!5-<,.4<2!6('J.8'8'9.!18896!E!<>:!5-<,.4<2!6('J.8'8'9.!18896!F!<>:!5-<,.4<2!6('J.8'8'9.!18896!7!<>:!5-<,.4<2!6('J.8'8'9.!A68!Z!<>:!5-<,.4<2!6('J.8'8'9.!A68!]!<>:!5-<,.4<2!6('J.8'8'9.!A68!E!<>:!5-<,.4<2!6('J.8'8'9.!A68!F!<>:!5-<,.4<2!6('J.8'8'9.!A68!7!<>:!5-<,.4<2!6('J.8'8'9.!#7.J'#1(!_18J1!Z!<>:!5-<,.4<2!6('J.8'8'9.!#7.J'#1(!_18J1!]!<>:!5-<,.4<2!6('J.8'8'9.!#7.J'#1(!_18J1!E!<>:!5-<,.4<2!6('J.8'8'9.!#7.J'#1(!_18J1!F!<>:!5-<,.4<2!6('J.8'8'9.!.6!Z!<>:!5-<,.4<2!6('J.8'8'9.!.6!]!<>:!5-<,.4<2!6('J.8'8'9.!.6!E!<>:!5-<,.4<2!6('J.8'8'9.!.6!F!<>:!5-<,.4<2!6('J.8'8'9.!6!61J!Z!<>:!5-<,.4<2!6('J.8'8'9.!6!61J!]!<>:!5-<,.4<2!6('J.8'8'9.!6!61J!E!<>:!5-<,.4<2!6('J.8'8'9.!6!61J!F!<>:!5-<,.4<2!6('J.8'8'9.!6!61J!7!<>:!5-<,.4<2!6('J.8'8'9.!'A9E!8718J1!#954\(2'56!7!<>:!5-<,.4<2!6('J.8'8'9.!J.8#C!Z!<>:!5-<,.4<2!6('J.8'8'9.!J.8#C!]!<>:!5-<,.4<2!6('J.8'8'9.!J.8#C!E!<>:!5-<,.4<2!6('J.8'8'9.!J.8#C!F!<>:!5-<,.4<2!6('J.8'8'9.!J.8#C!7!<>:!5-<,.4<2!6('J.8'8'9.!J.8#C!6.5.8'`\.4!Z!<>:!5-<,.4<2!6('J.8'8'9.!J.8#C!6.5.8'`\.4!]!<>:!5-<,.4<2!

6('J.8'8'9.!J.8#C!6.5.8'`\.4!E!<>:!5-<,.4<2!6('J.8'8'9.!J.8#C!6.5.8'`\.4!F!<>:!5-<,.4<2!6('J.8'8'9.!`\1('7.1(27!Z!<>:!5-<,.4<2!6('J.8'8'9.!`\1('7.1(27!]!<>:!5-<,.4<2!6('J.8'8'9.!`\1('7.1(27!E!<>:!5-<,.4<2!6('J.8'8'9.!`\1('7.1(27!F!<>:!5-<,.4<2!6('J.8'8'9.!`\1('J.9!Z!<>:!5-<,.4<2!6('J.8'8'9.!`\1('J.9!]!<>:!5-<,.4<2!6('J.8'8'9.!`\1('J.9!E!<>:!5-<,.4<2!6('J.8'8'9.!`\1('J.9!F!<>:!5-<,.4<2!6('J.8'8'9.!815A1M3!Z!<>:!5-<,.4<2!6('J.8'8'9.!815A1M3!]!<>:!5-<,.4<2!6('J.8'8'9.!815A1M3!E!<>:!5-<,.4<2!6('J.8'8'9.!815A1M3!F!<>:!5-<,.4<2!6('J.8'8'9.!812'9!Z!<>:!5-<,.4<2!6('J.8'8'9.!812'9!]!<>:!5-<,.4<2!6('J.8'8'9.!812'9!E!<>:!5-<,.4<2!6('J.8'8'9.!812'9!F!<>:!5-<,.4<2!6('J.8'8'9.!812'9!7!<>:!5-<,.4<2!6('J.8'8'9.!812'98718J!Z!<>:!5-<,.4<2!6('J.8'8'9.!812'98718J!]!<>:!5-<,.4<2!6('J.8'8'9.!812'98718J!E!<>:!5-<,.4<2!6('J.8'8'9.!812'98718J!F!<>:!5-<,.4<2!6('J.8'8'9.!812'98718J!7!<>:!5-<,.4<2!6('J.8'8'9.!41599D!Z!<>:!5-<,.4<2!6('J.8'8'9.!41599D!]!<>:!5-<,.4<2!6('J.8'8'9.!41599D!E!<>:!5-<,.4<2!6('J.8'8'9.!41599D!F!<>:!5-<,.4<2!6('J.8'8'9.!4156'5!Z!<>:!5-<,.4<2!6('J.8'8'9.!4156'5!]!<>:!5-<,.4<2!6('J.8'8'9.!4156'5!E!<>:!5-<,.4<2!6('J.8'8'9.!4156'5!F!<>:!5-<,.4<2!6('J.8'8'9.!4156'5!7!<>:!5-<,.4<2!6('J.8'8'9.!2.B1!Z!<>:!5-<,.4<2!6('J.8'8'9.!2.B1!]!<>:!5-<,.4<2!6('J.8'8'9.!2.B1!E!<>:!5-<,.4<2!6('J.8'8'9.!2.B1!F!<>:!5-<,.4<2!6('J.8'8'9.!2.B1!7!<>:!5-<,.4<2!6('J.8'8'9.!2.B1!#(144'#4!Z!<>:!5-<,.4<2!6('J.8'8'9.!2.B1!#(144'#4!F!<>:!5-<,.4<2!6('J.8'8'9.!2.B1!#(144'#4!E!<>:!5-<,.4<2!6('J.8'8'9.!2.B1!#(144'#4!]!<>:!5-<,.4<2!6('J.8'8'9.!6'527898!Z!<>:!5-<,.4<2!6('J.8'8'9.!6'527898!]!<>:!5-<,.4<2!6('J.8'8'9.!6'527898!E!<>:!5-<,.4<2!6('J.8'8'9.!6'527898!F!<>:!5-<,.4<2!6('J.8'8'9.!6'527898!7!<>:!5-<,.4<2!2159.J1#2!E[!<>GF!<>:!5-<,.4<2!2159.J1#2!F^!<>GF!<>:!5-<,.4<2!

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

Page 31: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

!

EZ!

925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!,;.+45)'4/.%,!%1!.;4(-1!/%!,;.+45)'4/.%,!%1!.;4(-1!/%!,;.+45)'4/.%,!%1!.;4(-1!/%!,;.+45)'4/.%,!%1!.;4(-1!/%!

'0;,,;.+%1;15%!D!)1%!5';((%!'0;,,;.+%1;15%!D!)1%!5';((%!'0;,,;.+%1;15%!D!)1%!5';((%!'0;,,;.+%1;15%!D!)1%!5';((%!,$;.<;5-'->4B)%!D!.4(B)%,$;.<;5-'->4B)%!D!.4(B)%,$;.<;5-'->4B)%!D!.4(B)%,$;.<;5-'->4B)%!D!.4(B)%!!!!

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

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

(%(!;'+%.1;+4 %(!+$2.;,%)+4B)%(!;)!(%41!/%!5%++%!5';((%!1%!(-1+!,;(!+-+;'%<%1+!%%%<,+%(!/A)1!.4(B)%!/A$2<-'=(%!5$%&!'%(!()*%+(!/23454+;4.%(!%1!6789F!

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

6('A.5.4.!^!<>:!5-<,.4<2!(25;+'%!6('8'D'9.!J.8#C!^!<>:!5-<,.4<2!(25;+'%!J'5'9'1A!^!<>:!5-<,.4<2!(25;+'%!

9D'9'1!Z[!<>:!5-<,.4<2!D!'4+2.;+4-1!,.-'-1>2%!9D'9'1!][!<>:!5-<,.4<2!D!'4+2.;+4-1!,.-'-1>2%!9D'9'1!^!<>:!5-<,.4<2!D!'4+2.;+4-1!,.-'-1>2%!

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

''!%(+!4<,-.+;1+!/%!,.2 %14.! -+.%!<2/%541!(4! -)(!J-)!)1!<%<+.%!/%! -+.%!3;<4''%,!)+%(!;++%41+!/A)1!/23454+!%1!6')5-(%C7C8$-(,$;+%!92($=/.->21;(%!5;.!)1!.4(B)%!/A$2<-'=(%!J/%(+.)5+4-1!/%(!>'-+)'%(!.-)>%(,!%%4(+%!; %5!/A;)+.%(!<2/45;<%1+(!/%!';!<)<%!5';((%!B)%!'%!>'4,4&4/%F!

925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!,;.+45)'4/.%,!%1!.;4(-1!/%!,;.+45)'4/.%,!%1!.;4(-1!/%!,;.+45)'4/.%,!%1!.;4(-1!/%!,;.+45)'4/.%,!%1!.;4(-1!/%!

'0;,,;.+%1;15%!D!)1%!5';((%!'0;,,;.+%1;15%!D!)1%!5';((%!'0;,,;.+%1;15%!D!)1%!5';((%!'0;,,;.+%1;15%!D!)1%!5';((%!,$;.<;5-'->4B)%!D!.4(B)%,$;.<;5-'->4B)%!D!.4(B)%,$;.<;5-'->4B)%!D!.4(B)%,$;.<;5-'->4B)%!D!.4(B)%!!!!

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

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

8(1`\.5'(!][[!<>:!5-<,.4<2!%1.-+2! 8(1`\.5'(!][[!<>:!5-<,.4<2!,%''45)'2!

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

''!%(+!4<,-.+;1+!/%!,.2 %14.! -+.%!<2/%541!(4! -)(!J-)!)1!<%<+.%!/%! -+.%!3;<4''%,!)+%(!;++%41+!/A)1!/23454+!%1!6')5-(%C7C8$-(,$;+%!92($=/.->21;(%!5;.!)1!.4(B)%!/A$2<-'=(%!J/%(+.)5+4-1!/%(!>'-+)'%(!.-)>%(,!%%4(+%!; %5!/A;)+.%(!<2/45;<%1+(!/%!';!<)<%!5';((%!B)%!'A$=/.-%=5$'-.-B)41%F!

4;1(!-+*%+!

Page 32: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

!

E]!

\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!!!!!

J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!!!!!

(;!,.4(%!/%!5%!<2/45;<%1+!%(+!,-((4+'%F!

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

9.M1JA\29(C'57!5-<,.4<2!,%''45)'2!!! '495'1D'9.!(1B9'4'.8!^!89\8!#.52!J]^[!<>G!^!<',:!(-')+4-1!41*%5+;+'%!

8'_12.8!5-<,.4<2!%1.-+2!!8'_'517!E[[<>GZ^[<>:!5-<,.4<2!%1.-+2!8'J1#21D'9!Z^[<>GH^<>:!5-<,.4<2!,%''45)'2!

8'J'#\8.:!5-<,.4<2!,%''45)'2!8'J'_95!Z^[!<>!5-<,.4<2!!8'J'_95!^[!<>!5-<,.4<2!8'J'_95!^[[<>G^<'!(-')+4-1!41*%5+;+'%!!8'J4218:!5-<,.4<2!,%''45)'2!

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

1!5%!*-).:!4'!10%%4(+%!,;(!/%!.4(B)%!$2<-'=+4B)%!4/%1+4342!5$%&!'%(!()*%+(!/23454%1+(!%1!6789!,-).!'%(!(,254;'4+2(!5-1+%1;1+!/%!'A4(-14;&4/%F!

(;!,.4(%!/%!5%!<2/45;<%1+!%(+!,-((4+'%F!

\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!

/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!!!!!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!!!!!

(;!,.4(%!/%!5%!<2/45;<%1+!%(+!,-((4+'%F!

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

#18A'9981!(.B99981!2.B1!Z[!<>GZ[[!<>:!5-<,.4<2!(25;+'%!

#18A'9981!(.B99981!2.B1!]^!<>G]^[!<>:!5-<,.4<2!(25;+'%!

#18A'9981!(.B99981!2.B1!(8!]^!<>GZ[[!<>:!5-<,.4<2!D!'4+2.;+4-1!,.-'-1>2%!

#18A'9981!(.B99981!2.B1!(8!^[!<>G][[!<>:!5-<,.4<2!D!'4+2.;+4-1!,.-'-1>2%!

9\99981:!>%'!41+%(+41;'!J999818!Z[[!<>G]^!<>:!5-<,.4<2!B);/.4(25;+'%!J999818!Z]^!JZ[[<>G]^<>,:!>2')'%!J999818!Z]^!9'48.84'A(.!JZ[[<>G]^<>,:!5-<,.4<2!(25;+'%!,-).!()(,%1(4-1!+) ;+'%!

J999818!]^[!J][[!<>G^[<>,:!>2')'%!

J999818!]^[!J][[!<>G^[<>,:!5-<,.4<2!B);/.4(25;+'%!J999818!7]:^!J^[<>GZ]:^<>,:!>2')'%!J999818!(8!Z]^!JZ[[<>G]^<>,:!>2')'%!D!'4+2.;+4-1!,.-'-1>2%!

4'5.J.2!Z[[<>GZ[<>:!5-<,.4<2!(25;+'%!!4'5.J.2!]^[<>G]^<>:!5-<,.4<2!(25;+'%!!4'5.J.2!(8!]^<>GZ[[<>:!5-<,.4<2!D!'4+2.;+4-1!,.-'-1>2%!

4'5.J.2!(8!^[<>G][[<>:!5-<,.4<2!D!'4+2.;+4-1!,.-'-1>2%!

421(.B9!Z[[<>G]^<>G][[<>:!5-<,.4<2!,%''45)'2!!421(.B9!Z^[<>GEH:^<>G][[<>:!5-<,.4<2!,%''45)'2!!421(.B9!^[<>GZ]:^<>G][[<>:!5-<,.4<2!,%''45)'2!!

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

1!5%!*-).:!4'!10%%4(+%!,;(!/%!.4(B)%!$2<-'=+4B)%!4/%1+4342!5$%&!'%(!()*%+(!/23454%1+(!%1!6789!,-).!'%(!(,254;'4+2(!5-1+%1;1+!/%!';!'2 -/-,;F!!

(;!,.4(%!/%!5%!<2/45;<%1+!%(+!,-((4+'%F!

Page 33: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

!

EE!

925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!,;.+45)'4/.%,!%1!.;4(-1!/%!5;(!-+(%. 2(!,;.+45)'4/.%,!%1!.;4(-1!/%!5;(!-+(%. 2(!,;.+45)'4/.%,!%1!.;4(-1!/%!5;(!-+(%. 2(!,;.+45)'4/.%,!%1!.;4(-1!/%!5;(!-+(%. 2(!

/A$2<-'=(%!;4>)?/A$2<-'=(%!;4>)?/A$2<-'=(%!;4>)?/A$2<-'=(%!;4>)?!!!!

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

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

21B15'#!^<>G<(:!(-')+4-1!,-).!,%.3)(4-1!21B15'#!]^[<>:!5-<,.4<2!,%''45)'2!(25;+'%!

21B15'#!^[[<>:!5-<,.4<2!,%''45)'2!(25;+'%!

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

(;!(2 -3'-%;541%!;,,;.+4%1+!D!';!3;<4''%!/%(!B)41-'-1%(F!(%(!;'+%.1;+4 %(!+$2.;,%)+4B)%(!;)!(%41!/%!5%++%!3;<4''%!1%!(-1+!,;(!+-+;'%<%1+!%%%<,+%(!/A)1!.4(B)%!/A$2<-'=(%!5$%&!'%(!()*%+(!/23454+;4.%(!%1!6789F!

B-)(!/% %&!413-.<%.! -+.%!<2/%541!(4! -)(!J-)!)1!<%<+.%!/%! -+.%!3;<4''%,!)+%(!;++%41+!/A)1!/23454+!%1!6')5-(%C7C8$-(,$;+%!92($=/.->21;(%!5;.!)1!.4(B)%!/A$2<-'=(%!J/%(+.)5+4-1!/%(!>'-+)'%(!.-)>%(,!%%4(+%!; %5!';!'2 -3'-%;541%!;/<414(+.2%!,;.! -4%!-.;'%!-)!41*%5+;+'%F!

925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!,;.+45)'4/.%,!%1!.;4(-1!/%!,;.+45)'4/.%,!%1!.;4(-1!/%!,;.+45)'4/.%,!%1!.;4(-1!/%!,;.+45)'4/.%,!%1!.;4(-1!/%!

'A;,,;.+%1;15%!D!)1%!3;<4''%!'A;,,;.+%1;15%!D!)1%!3;<4''%!'A;,,;.+%1;15%!D!)1%!3;<4''%!'A;,,;.+%1;15%!D!)1%!3;<4''%!,$;.<;5-'->4B)%!D!.4(B)%,$;.<;5-'->4B)%!D!.4(B)%,$;.<;5-'->4B)%!D!.4(B)%,$;.<;5-'->4B)%!D!.4(B)%!!!!

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

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

9.#1(96'_(9M:!5-<,.4<2!,%''45)'2!(25;+'%! (96'_(9M!F[[!<>:!5-<,.4<2!,%''45)'2!(25;+'%!

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

(%(!;'+%.1;+4 %(!+$2.;,%)+4B)%(!;)!(%41!/%!5%++%!3;<4''%!1%!(-1+!,;(!+-+;'%<%1+!%%%<,+%(!/A)1!.4(B)%!/A$2<-'=(%!5$%&!'%(!()*%+(!/23454+;4.%(!%1!6789F!

''!%(+!4<,-.+;1+!/%!,.2 %14.! -+.%!<2/%541!(4! -)(!J-)!)1!<%<+.%!/%! -+.%!3;<4''%,!)+%(!;++%41+!/A)1!/23454+!%1!6')5-(%C7C8$-(,$;+%!92($=/.->21;(%!5;.!)1!.4(B)%!/A$2<-'=(%!J/%(+.)5+4-1!/%(!>'-+)'%(!.-)>%(,!%%4(+%!; %5!/A;)+.%(!<2/45;<%1+(!/%!';!<)<%!3;<4''%!B)%!';!'-<23'-%;541%F!

Page 34: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

!

EF!

\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!

/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!!!!!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!!!!!

(;!,.4(%!/%!5%!<2/45;<%1+!%(+!,-((4+'%F!

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

(18'1J!]^[!<>:!5-<,.4<2!(25;+'%!! (18'1J!^[!<>:!5-<,.4<2!

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

1!5%!*-).:!4'!10%%4(+%!,;(!/%!.4(B)%!$2<-'=+4B)%!4/%1+4342!5$%&!'%(!()*%+(!/23454%1+(!%1!6789!,-).!'%(!(,254;'4+2(!5-1+%1;1+!/%!';!<23'-B)41%F!!

(;!,.4(%!/%!5%!<2/45;<%1+!%(+!,-((4+'%F!

\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!

/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!!!!!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!!!!!

(;!,.4(%!/%!5%!<2/45;<%1+!%(+!,-((4+'%F!

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

'59J1M!F[[!,,<!<-'%G<-'%:!>;&!,-).!41$;';+4-1!C'59M!]]^!,,<!<-'%G<-'%:!>;&!,-).!41$;';+4-1:!%1!+-)+%4''%!

C'59M!F^[!,,<!<-'%G<-'%:!>;&!,-).!41$;';+4-1:!%1!+-)+%4''%!

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

1!5%!*-).:!4'!10%%4(+%!,;(!/%!.4(B)%!$2<-'=+4B)%!4/%1+4342!5$%&!'%(!()*%+(!/23454%1+(!%1!6789!,-).!'%(!(,254;'4+2(!5-1+%1;1+!/)!<-1-%=/%!/A;&-+%F!

(;!,.4(%!/%!5%!<2/45;<%1+!%(+!,-((4+'%F!

\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!

/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!!!!!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!!!!!

(;!,.4(%!/%!5%!<2/45;<%1+!%(+!,-((4+'%F!

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

A1\J1('5.!Z]!89\8!#.52:!5./<%! 838199(!Z]!89\8!#.52:!5./<%!

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

1!5%!*-).:!4'!10%%4(+%!,;(!/%!.4(B)%!$2<-'=+4B)%!4/%1+4342!5$%&!'%(!()*%+(!/23454%1+(!%1!6789!,-).!'%(!(,254;'4+2(!5-1+%1;1+!/%!';!<-.,$-'41%F!!

(;!,.4(%!/%!5%!<2/45;<%1+!%(+!,-((4+'%F!

Page 35: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

!

E^!

925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!,;.+45)'4/.%,!%1!.;4(-1!/%!,;.+45)'4/.%,!%1!.;4(-1!/%!,;.+45)'4/.%,!%1!.;4(-1!/%!,;.+45)'4/.%,!%1!.;4(-1!/%!

'A;,,;.+%1;15%!D!)1%!3;<4''%!'A;,,;.+%1;15%!D!)1%!3;<4''%!'A;,,;.+%1;15%!D!)1%!3;<4''%!'A;,,;.+%1;15%!D!)1%!3;<4''%!,$;.<;5-'->4B)%!D!.4(B)%,$;.<;5-'->4B)%!D!.4(B)%,$;.<;5-'->4B)%!D!.4(B)%,$;.<;5-'->4B)%!D!.4(B)%!!!!

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

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

'D'(9M!F[[!<>:!5-<,.4<2!,%''45)'2! 9#2.681!F[[!<>:!5-<,.4<2!,%''45)'2!

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

(%(!;'+%.1;+4 %(!+$2.;,%)+4B)%(!;)!(%41!/%!5%++%!3;<4''%!1%!(-1+!,;(!+-+;'%<%1+!%%%<,+%(!/A)1!.4(B)%!/A$2<-'=(%!5$%&!'%(!()*%+(!/23454+;4.%(!%1!6789F!

''!%(+!4<,-.+;1+!/%!,.2 %14.! -+.%!<2/%541!(4! -)(!J-)!)1!<%<+.%!/%! -+.%!3;<4''%,!)+%(!;++%41+!/A)1!/23454+!%1!6')5-(%C7C8$-(,$;+%!92($=/.->21;(%!5;.!)1!.4(B)%!/A$2<-'=(%!J/%(+.)5+4-1!/%(!>'-+)'%(!.-)>%(,!%%4(+%!; %5!/A;)+.%(!<2/45;<%1+(!/%!';!<)<%!3;<4''%!B)%!';!<-%43'-%;541%F!

#-1+.%#-1+.%#-1+.%#-1+.%CCCC41/4B)2%41/4B)2%41/4B)2%41/4B)2%!!!!

(%!.%5-).(!D!)1%!;'+%.1;+4 %!+$2.;,%)+4B)%!%(+!4<,2.;+43F!

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

_\819152'5.!^[<>:!>2')'%!_\8199'5.!^[<>:!5-<,.4<2!

J'#8999'5.:!>2')'%!

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

4;1(!-+*%+!

(%!14+.-3).;1+-T1%!1%!/-4+!,;(!)+.%!)+4'4(2!%1!5;(!/%!/23454+!%1!6789F!1)((4:! -)(!/% %&!;+(-')<%1+!413-.<%.! -+.%!<2/%541! -)(!/% %&!;+(-')<%1+!413-.<%.! -+.%!<2/%541! -)(!/% %&!;+(-')<%1+!413-.<%.! -+.%!<2/%541! -)(!/% %&!;+(-')<%1+!413-.<%.! -+.%!<2/%541!(4! -)(!J-)!)1!<%<+.%!/%! -+.%!3;<4''%,!)+%(!;++%41+!/A)1!/23454+!%1!6')5-(%C7C8$-(,$;+%!92($=/.->21;(%F!

Page 36: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

!

E7!

\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!

/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!!!!!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!!!!!

(;!,.4(%!/%!5%!<2/45;<%1+!%(+!,-((4+'%F!

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

5'28'12.:!,-)/.%!'=-,$4'4(2%!%+!(-')+4-1!,-).!,.2,;.;+4-1!41*%5+;+'%!J'FBF,!<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

1!5%!*-).:!4'!10%%4(+%!,;(!/%!.4(B)%!$2<-'=+4B)%!4/%1+4342!5$%&!'%(!()*%+(!/23454%1+(!%1!6789!,-).!'%(!(,254;'4+2(!5-1+%1;1+!/)!14+.-,.)((4;+%F!!

(;!,.4(%!/%!5%!<2/45;<%1+!%(+!,-((4+'%F!

#-1+.%#-1+.%#-1+.%#-1+.%CCCC41/4B)2%41/4B)2%41/4B)2%41/4B)2%!!!!

(%!.%5-).(!D!)1%!;'+%.1;+4 %!+$2.;,%)+4B)%!%(+!4<,2.;+43F!

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

1B1_98215!1!(1!5981J'99838'5.:!5-<,.4<2!%1.-+2!1B1_98215!1!(1!5981J'99838'5.:!(-')+4-1!41*%5+;+'%!%1!;<,-)'%!

1B1_98215!1!(1!5981J'99838'5.:!(),,-(4+-4.%!#._1('5.!8381D9(.!1!(1!5981J'99838'5.:!,-)/.%!,-).!(-')+4-1!+) ;+'%!

59B1(6'5.!^[[!<>:!5-<,.4<2!,%''45)'2!59B1(6'5.!Z>:!(),,-(4+-4.%!59B1(6'5.!]:^>G^<(:!(-')+4-1!41*%5+;+'%!%1!;<,-)'%!9821('995!1!(1!5981J'99838'5.:!5-<,.4<2!,%''45)'2!9821('995!1!(1!5981J'99838'5.:!(),,-(4+-4.%!

838.2715.!1!(1!5981J'99838'5.!]^!89\8!#.52:!(-')+4-1!+) ;+'%!%1!>-)++%(!

41(6391(!1!(1!5981J'99838'5.:!5-<,.4<2!41(6391(!1!(1!5981J'99838'5.!19\(2.4:!(),,-(4+-4.%!41(6391(!1!(1!5981J'99838'5.!.5_1524:!(),,-(4+-4.%!B'4#.81(6'5.!!_982.!1!(1!5981J'99838'5.:!5-<,.4<2!B'4#.81(6'5.!!_982.!1!(1!5981J'99838'5.:!(-')+4-1!41*%5+;+'%!

B'4#.81(6'5.!!_982.!1!(1!5981J'99838'5.:!(),,-(4+-4.%!

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

1!1-+%.!B)A%1!_.;15%!%+!/;1(!/A;)+.%(!,;=(!%).-,2%1(:!'%(!1JJ!/%(!(,254;'4+2(!5-1+%1;1+!/%!';!1-.;<4/-,=.41%!-1+!2+2!(),,.4<2%(F!

(;!1-.;<4/-,=.41%!1%!/-4+!,;(!)+.%!)+4'4(2%!%1!5;(!/%!/23454+!%1!6789F!1)((4:! -)(!/% %&!;+(-')<%1+!413-.<%.! -+.%! -)(!/% %&!;+(-')<%1+!413-.<%.! -+.%! -)(!/% %&!;+(-')<%1+!413-.<%.! -+.%! -)(!/% %&!;+(-')<%1+!413-.<%.! -+.%!<2/%541<2/%541<2/%541<2/%541!(4! -)(!J-)!)1!<%<+.%!/%! -+.%!3;<4''%,!)+%(!;++%41+!/A)1!/23454+!%1!6')5-(%C7C8$-(,$;+%!92($=/.->21;(%F!

Page 37: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

!

EH!

925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!,;.+45)'4/.%,!%1!.;4(-1!/%!5;(!-+(%. 2(!,;.+45)'4/.%,!%1!.;4(-1!/%!5;(!-+(%. 2(!,;.+45)'4/.%,!%1!.;4(-1!/%!5;(!-+(%. 2(!,;.+45)'4/.%,!%1!.;4(-1!/%!5;(!-+(%. 2(!

/A$2<-'=(%!;4>)?/A$2<-'=(%!;4>)?/A$2<-'=(%!;4>)?/A$2<-'=(%!;4>)?!!!!

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

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

598_(9M1#'5.!18896!F[[!<>:!5-<,.4<2!,%''45)'2!598_(9M1#'5.!A'961815!F[[!<>:!5-<,.4<2!,%''45)'2!598_(9M1#'5.!.6!F[[!<>:!5-<,.4<2!,%''45)'2!598_(9M1#'5.!'B1M!F[[!<>:!5-<,.4<2!,%''45)'2!598_(9M1#'5.!J.8#C!F[[!<>:!5-<,.4<2!,%''45)'2!598_(9M1#'5.!`\1('J.9!F[[!<>:!5-<,.4<2!,%''45)'2!

598_(9M1#'5.!815A1M3!F[[!<>:!5-<,.4<2!,%''45)'2!598_(9M1#'5.!812'98718J!F[[!<>:!5-<,.4<2!,%''45)'2!598_(9M1#'5.!41599D!F[[!<>:!5-<,.4<2!,%''45)'2!598_(9M1#'5.!2.B1!F[[!<>:!5-<,.4<2!,%''45)'2!598_(9M1#'5.!6'527898!F[[!<>:!5-<,.4<2!,%''45)'2!5989M'5.!F[[!<>:!5-<,.4<2!%1.-+2!

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

(;!1-.3'-%;541%!;,,;.+4%1+!D!';!3;<4''%!/%(!B)41-'-1%(F!(%(!;'+%.1;+4 %(!+$2.;,%)+4B)%(!;)!(%41!/%!5%++%!3;<4''%!1%!(-1+!,;(!+-+;'%<%1+!%%%<,+%(!/A)1!.4(B)%!/A$2<-'=(%!5$%&!'%(!()*%+(!/23454+;4.%(!%1!6789F!

B-)(!/% %&!413-.<%.! -+.%!<2/%541!(4! -)(!J-)!)1!<%<+.%!/%! -+.%!3;<4''%,!)+%(!;++%41+!/A)1!/23454+!%1!6')5-(%C7C8$-(,$;+%!92($=/.->21;(%!5;.!)1!.4(B)%!/A$2<-'=(%!J/%(+.)5+4-1!/%(!>'-+)'%(!.-)>%(,!%%4(+%!; %5!';!1-.3'-%;541%!;/<414(+.2%!,;.! -4%!-.;'%F!

\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!!!!!

J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!!!!!

(;!,.4(%!/%!5%!<2/45;<%1+!,;.! -4%!-,$+;'<4B)%!%(+!,-((4+'%F!

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

#7'A89M'5.![:E!89\8!#.52:!5-''=.%!%1!(-')+4-1!

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

(;!5-15%1+.;+4-1!,';(<;+4B)%!%1!1-.3'-%;541%!/;1(!'%!(;1>!;,./(!41(+4'';+4-1!-5)';4.%!5-..%(,-1/!D!<-41(!/%!ZS!/%(!+;)%!.%+.-) 2(!;)!,45!,';(<;+4B)%!;,./(!;/<414(+.;+4-1!-.;'%!/)!,.-/)4+!D!/-(%!+$2.;,%)+4B)%F!

(;!,.4(%!/%!5%!<2/45;<%1+!,;.! -4%!-,$+;'<4B)%!%(+!,-((4+'%F!

Page 38: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

!

EL!

925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!,;.+45)'4/.%,!%1!.;4(-1!/%!,;.+45)'4/.%,!%1!.;4(-1!/%!,;.+45)'4/.%,!%1!.;4(-1!/%!,;.+45)'4/.%,!%1!.;4(-1!/%!

'0;,,;.+%1;15%!D!)1%!3;<4''%!'0;,,;.+%1;15%!D!)1%!3;<4''%!'0;,,;.+%1;15%!D!)1%!3;<4''%!'0;,,;.+%1;15%!D!)1%!3;<4''%!,$;.<;5-'->4B)%!D!.4(B)%!,$;.<;5-'->4B)%!D!.4(B)%!,$;.<;5-'->4B)%!D!.4(B)%!,$;.<;5-'->4B)%!D!.4(B)%!!!!!

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

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

J959_(9#.2!][[!<>:!5-<,.4<2!,%''45)'2!9_(9#.2!][[!<>:!5-<,.4<2!,%''45)'2!(25;+'%!9_(9#.2!][[!<>GF[!<':!(-')+4-1!41*%5+;+'%!,-).!,%.3)(4-1!

9_(9M1#'5.!16\.22152!][[!<>GF[!<':!(-')+4-1!,-).!,%.3)(4-1!

9_(9M1#'5.!18896!][[!<>:!5-<,.4<2!,%''45)'2!(25;+'%!9_(9M1#'5.!A'961(.5'`\.!][[!<>:!5-<,.4<2!,%''45)'2!(25;+'%!

9_(9M1#'5.!A'961815!][[!<>:!5-<,.4<2!,%''45)'2!(25;+'%!

9_(9M1#'5.!91C921!8718J!][[!<>GF[!<':!(-')+4-1!,-).!,%.3)(4-1!

9_(9M1#'5.!.6!][[!<>:!5-<,.4<2!,%''45)'2!(25;+'%!9_(9M1#'5.!6!61J!][[!<>:!5-<,.4<2!,%''45)'2!(25;+'%!9_(9M1#'5.!'B1M!][[!<>:!5-<,.4<2!,%''45)'2!(25;+'%!9_(9M1#'5.!J1#98718J1!][[!<>GF[!<':!(-')+4-1!,-).!,%.3)(4-1!

9_(9M1#'5.!J.8#C!][[!<>:!5-<,.4<2!,%''45)'2!(25;+'%!9_(9M1#'5.!J.8#C!][[!<>GF[!<':!(-')+4-1!,-).!,%.3)(4-1!

9_(9M1#'5.!J.8#C!6.5.8'`\.4!][[!<>GF[!<':!(-')+4-1!,-).!,%.3)(4-1!

9_(9M1#'5.!J.8#C!J959994.!][[!<>:!5-<,.4<2!,%''45)'2!(25;+'%!

9_(9M1#'5.!598!][[!<>:!5-<,.4<2!,%''45)'2!(25;+'%!9_(9M1#'5.!5989'#!8718J1!][[!<>GF[!<':!(-')+4-1!,-).!,%.3)(4-1!

9_(9M1#'5.!`\1('J.9!][[!<>:!5-<,.4<2!,%''45)'2!(25;+'%F!

9_(9M1#'5.!`\1('J.9!][[!<>GF[!<':!(-')+4-1!,-).!,%.3)(4-1!

9_(9M1#'5.!815A1M3!][[!<>:!5-<,.4<2!,%''45)'2!(25;+'%!

9_(9M1#'5.!812'98718J!][[!<>:!5-<,.4<2!,%''45)'2!(25;+'%!

9_(9M1#'5.!8._!][[!<>:!5-<,.4<2!,%''45)'2!(25;+'%!9_(9M1#'5.!886!][[!<>:!5-<,.4<2!,%''45)'2!(25;+'%!C!.1!5-).(!/A;..)+!/%!5-<<%.54;'4(;+4-1!

9_(9M1#'5.!41599D!][[!<>:!5-<,.4<2!,%''45)'2!(25;+'%!9_(9M1#'5.!4.2!][[!<>:!5-<,.4<2!,%''45)'2!(25;+'%!9_(9M1#'5.!2.B1!][[!<>:!5-<,.4<2!,%''45)'2!(25;+'%!9_(9M1#'5.!6'527898!][[!<>:!5-<,.4<2!,%''45)'2!(25;+'%!

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

(0-3'-%;541%!;,,;.+4%1+!D!';!3;<4''%!/%(!B)41-'-1%(F!(%(!;'+%.1;+4 %(!+$2.;,%)+4B)%(!;)!(%41!/%!5%++%!3;<4''%!1%!(-1+!,;(!+-+;'%<%1+!%%%<,+%(!/A)1!.4(B)%!/A$2<-'=(%!5$%&!'%(!()*%+(!/23454+;4.%(!%1!6789F!

''!%(+!4<,-.+;1+!/%!,.2 %14.! -+.%!<2/%541!(4! -)(!J-)!)1!<%<+.%!/%! -+.%!3;<4''%,!)+%(!;++%41+!/A)1!/23454+!%1!6')5-(%C7C8$-(,$;+%!92($=/.->21;(%!5;.!)1!.4(B)%!/A$2<-'=(%!J/%(+.)5+4-1!/%(!>'-+)'%(!.-)>%(,!%%4(+%!; %5!/A;)+.%(!<2/45;<%1+(!/%!';!<)<%!3;<4''%!B)%!'A-3'-%;541%F!

Page 39: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

!

E"!

\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!!!!!

J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!!!!!

(;!,.4(%!/%!5%!<2/45;<%1+!,;.! -4%!-,$+;'<4B)%!-)!;).45)';4.%!%(+!,-((4+'%F!

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

.M9#'5.![:E!89\8!#.52:!5-''=.%!.M9#'5.!Z:]!<>G[:F!<':!5-''=.%!%1!.254,4%1+!)14/-(%!

9_(9#.2!Z:^!<>G[:^!<':!(-')+4-1!;).45)';4.%!%1!.254,4%1+!)14/-(%!

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

(0%%,-(4+4-1!(=(+2<4B)%!D!'0-3'-%;541%!;,./(!Z[!*-).(!/%!+.;4+%<%1+!-5)';4.%!%(+!Z[[[!3-4(!<-41(!4<,-.+;1+%!B)%!'-.(!/%!'0;/<414(+.;+4-1!-.;'%!(+;1/;./F!9;1(!/%(!5-1/4+4-1(!1-.<;'%(!/0)+4'4(;+4-1:!4'!1A=!;!,;(!/%!,;((;>%!(=(+2<4B)%!%1!41(+4'';+4-1!;).45)';4.%F!

(;!,.4(%!/%!5%!<2/45;<%1+!!,;.! -4%!-,$+;'<4B)%!-)!;).45)';4.%!%(+!,-((4+'%F!

925-1(%4''2%!925-1(%4''2%!925-1(%4''2%!925-1(%4''2%!!!!!D!,-(-'->4%!2'% 2%D!,-(-'->4%!2'% 2%D!,-(-'->4%!2'% 2%D!,-(-'->4%!2'% 2%!!!!

#$%&!'%(!()*%+(!,-.+%).(!/0)1!/23454+!%1!6789:!/%(!5;(!/0$2<-'=(%!;4>)?!-1+!2+2!.;,,-.+2(!; %5!/%(!/-(%(!2'% 2%(!/%!,;.;52+;<-':!50%(+CDC/4.%!(),2.4%).%(!D!';!,-(-'->4%!<;%4<;'%!B)-+4/4%11%!.%5-<<;1/2%F!''!%(+!4<,-.+;1+!/%!.%(,%5+%.!'%(!,-(-'->4%(F!!

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

1#2'_.9!I9\8!.2!5\'2:!5-<,.4<2!1#2'_.9!87\J.:!5-<,.4<2!1#2895:!5-<,.4<2!%33%. %(5%1+!!

1_.A83(:!5-<,.4<2!%33%. %(5%1+!!

1_.8199(!^[[!<>:!5-<,.4<2!(25;+'%!1C'599(!_9\85'.8!^[[!<>:!5-<,.4<2!(25;+'%!1(6'#1(J!F[[!<>G]^!<>:!5-<,.4<2!

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

(%(!,-(-'->4%(!<;%4<;'%(!B)-+4/4%11%(!.%5-<<;1/2%(!(-1+!34%2%(!D!Z!>!,;.!,.4(%!F!3-4(!,;.!*-).!,-).!'0;/)'+%:!%+!7[<>GX>!,;.!*-).!5$%&!'0%13;1+:!D!.2,;.+4.!%1!F!-)!7!,.4(%(:!(-4+!%1 4.-1!Z^<>GX>!+-)+%(!'%(!7!$%).%(!-)!Z[<>GX>!+-)+%(!'%(!F!$%).%(F!9A;)+.%(!<2/45;<%1+(!,%) %1+!5-1+%14.!/)!,;.;52+;<-'F!.1!5;(!/A;((-54;+4-1:!4'!%(+!4<,-.+;1+!/A)+.%!+./(!;++%1+43!D!1%!,;(!/2,;((%.!'%(!/-(%(!<;%4<;'%(!B)-+4/4%11%(!.%5-<<;1/2%(F!

(%!,;.;52+;<-'!/-4+!)+.%!)+4'4(2!; %5!,.)/%15%!%1!5;(!/%!/23454+!%1!6')5-(%C7C8$-(,$;+%!92($=/.->21;(%:!5;.!/%(!/-(%(!2'% 2%(!/%!,;.;52+;<-'!-1+!,)!,.- -B)%.!/%(!$2<-'=(%(!J/%(+.)5+4-1!/%(!>'-+)'%(!.-)>%(,F!''!%(+!4<,-.+;1+!/%!.%(,%5+%.!'%(!,-(-'->4%(!J'4.%!;++%1+4 %<%1+!';!.)+.4B)%!-,-(-'->4%-!/%!';!1-+45%!/%! -+.%!<2/45;<%1+,F!.1!5;(!/%!/-)+%:!/%<;1/%&!'A; 4(!/%! -+.%!<2/%541!-)!/%! -+.%!,$;.<;54%1F!

Page 40: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

!

F[!

1(6'4.91(:!5-<,.4<2!1(69#.9!E[!<>GF[[!<>:!>2')'%!1(6999(!E^[!<>:!5-<,.4<2!,%''45)'2!1(6987'59(:!(),,-(4+-4.%!1(6928983(:!(),,-(4+-4.%!152'68'88'5.!1\!8181#.21J9(!.212!68'881(:!,-)/.%!,-).!(-')+4-1!+) ;+'%!%1!(;5$%+!!

18'8.M!Z[!89\8!#.52:!(-')+4-1!+) ;+'%!18\J1(!Z][!<>:!(),,-(4+-4.%!18\J1(!E[[!<>:!(),,-(4+-4.%!18871:!>2')'%!A895#98'59(!.2124!68'881\M:!,-)/.%!,-).!(-')+4-1!+) ;+'%!%1!(;5$%+C/-(%!

A895#98'59(!87\J.:!>2')'%!#1(J94.93(!.5_1524:!(),,-(4+-4.%!!

#1J879#1(3829(!19\(2.4:!(),,-(4+-4.%!#1J879#1(3829(!59\88'44954:!(),,-(4+-4.%!#._1('5.!71\27:!,-)/.%!-.;'%!%1!(;5$%+!J;)!,;.;52+;<-',!

#.`\'53(:!5-<,.4<2!,%''45)'2!!

#.21_.'5.!^[[!<>G^[!<>:!5-<,.4<2!%33%. %(5%1+!(25;+'%!

#.21_.'5.!^[[!<>G^[!<>:!5-<,.4<2!,%''45)'2!(25;+'%!#(18199(!59\88'44954!7[!<>G]!<':!(-')+4-1!+) ;+'%!#(18199(!Z][!<>:!5-<,.4<2!%33%. %(5%1+!#(18199(!^[[!<>!#1_.'5.:!5-<,.4<2!#(18199(!^[[!<>:!5-<,.4<2!%33%. %(5%1+!(25;+'%!#(18199(!^[[!<>:!5-<,.4<2!(25;+'%!#(18199(!#1_.'5.!^[[!<>G^[!<>:!5-<,.4<2!%33%. %(5%1+!

#(18199(!#99.'5.!^[[!<>G][!<>:!5-<,.4<2!#999('8815.!19\(2.4:!5-<,.4<2!(25;+'%!#999('8815.!.5_1524:!5-<,.4<2!(25;+'%!#9J881(63(!F[[!<>G][!<>:!5-<,.4<2!(25;+'%!#9J881(49(!^[[!<>:!5-<,.4<2!D!()5%.!#9881(6'8!F[[!<>G][!<>:!5-<,.4<2!(25;+'%!#9`\.(\4.91(!8181#.21J9(!19\(2.4:!(),,-(4+-4.%!#9`\.(\4.91(!8181#.21J9(!.5_1524:!(),,-(4+-4.%!#9`\.(\4.91(!8181#.21J9(!59\88'44954:!(),,-(4+-4.%!

91_1(615!^[[!<>:!>2')'%!91_1(615!19\(2.4!7[[!<>:!(),,-(4+-4.%!91_1(615!Z!>:!5-<,.4<2!,%''45)'2!91_1(615!Z!>:!5-<,.4<2!(25;+'%!91_1(615!#99.'5.:!5-<,.4<2!,%''45)'2!9.M18!E[!<>GF[[!<>:!>2')'%!9.M28988989M387.5.!8181#.21J9(!1(J\4!E[!<>GF[[!<>:!>2')'%!

9.M28988989M387.5.!8181#.21J9(!1(2.8!E[!<>GF[[!<>:!>2')'%!

9.M28988989M387.5.!8181#.21J9(!18896!E[!<>GF[[!<>:!>2')'%!

9.M28988989M387.5.!8181#.21J9(!A'961(.5'`\.!

E[!<>GF[[!<>:!>2')'%!9.M28988989M387.5.!8181#.21J9(!A'961815!E[!<>GF[[!<>:!>2')'%!

9.M28988989M387.5.!8181#.21J9(!.6!E[!<>GF[[!<>:!>2')'%!

9.M28988989M387.5.!8181#.21J9(!.M8158718J!E[!<>GF[[!<>:!>2')'%!

9.M28988989M387.5.!8181#.21J9(!6!61J!E[!<>GF[[!<>:!>2')'%!

9.M28988989M387.5.!8181#.21J9(!7.M1(!E[!<>GF[[!<>:!>2')'%!

9.M28988989M387.5.!8181#.21J9(!'49J.9!E[!<>GF[[!<>:!>2')'%!

9.M28988989M387.5.!8181#.21J9(!'B1M!E[!<>GF[[!<>:!>2')'%!

9.M28988989M387.5.!8181#.21J9(!J.8#C!E[!<>GF[[!<>:!>2')'%!

9.M28988989M387.5.!8181#.21J9(!`\1('J.9!E[!<>GF[[!<>:!>2')'%!

9.M28988989M387.5.!8181#.21J9(!812'98718J!E[!<>GF[[!<>:!>2')'%!

9.M28988989M387.5.!8181#.21J9(!886!E[!<>GF[[!<>:!>2')'%!

9.M28988989M387.5.!8181#.21J9(!41599D!E[!<>GF[[!<>:!>2')'%!

9.M28988989M387.5.!8181#.21J9(!499.8718!E[!<>GF[[!<>:!>2')'%!

9.M28988989M387.5.!8181#.21J9(!2.B1!E[!<>GF[[!<>:!>2')'%!

9.M28988989M387.5.!8181#.21J9(!27.818('M!E[!<>GF[[!<>:!>2')'%!

9.M28988989M387.5.!8181#.21J9(!298(15!E[!<>GF[[!<>:!>2')'%!

9.M28988989M387.5.!8181#.21J9(!D39\4!E[!<>GF[[!<>:!>2')'%!

9.M28988989M387.5.G8181#.21J9(G#1_.'5.!1(J\4!]H!<>GF[[!<>GE[!<>:!5-<,.4<2!

9.M28988989M387.5.G8181#.21J9(G#1_.'5.!1(2.8!]H!<>GF[[!<>GE[!<>:!5-<,.4<2!

9.M28988989M387.5.G8181#.21J9(G#1_.'5.!18896!]H!<>GF[[!<>GE[!<>:!5-<,.4<2!

9.M28988989M387.5.G8181#.21J9(G#1_.'5.!A'961815!]H!<>GF[[!<>GE[!<>:!5-<,.4<2!

9.M28988989M387.5.G8181#.21J9(G#1_.'5.!.6!]H!<>GF[[!<>GE[!<>:!5-<,.4<2!

9.M28988989M387.5.G8181#.21J9(G#1_.'5.!6!61J!]H!<>GF[[!<>GE[!<>:!5-<,.4<2!

9.M28988989M387.5.G8181#.21J9(G#1_.'5.!J.8#C!]H!<>GF[[!<>GE[!<>:!5-<,.4<2!

9.M28988989M387.5.G8181#.21J9(G#1_.'5.!J.8#C!6.5.8'`\.4!]H!<>GF[[!<>GE[!<>:!5-<,.4<2!

9.M28988989M387.5.G8181#.21J9(G#1_.'5.!`\1('J.9!]H!<>GF[[!<>GE[!<>:!5-<,.4<2!

9.M28988989M387.5.G8181#.21J9(G#1_.'5.!812'98718J!]H!<>GF[[!<>GE[!<>:!5-<,.4<2!

9.M28988989M387.5.G8181#.21J9(G#1_.'5.!886!]H!<>GF[[!<>GE[!<>:!5-<,.4<2!

9.M28988989M387.5.G8181#.21J9(G#1_.'5.!41599D!]H<>GF[[!<>GE[!<>:!5-<,.4<2!

9.M28988989M387.5.G8181#.21J9(G#1_.'5.!2.B1!]H!<>GF[[!<>GE[!<>:!5-<,.4<2!

9.M28988989M387.5.G8181#.21J9(G#1_.'5.!6'527898!]H!<>GF[[!<>GE[!<>:!5-<,.4<2!

9.M28988989M387.5.G8181#.21J9(G#1_.'5.!D39\4!

Page 41: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

!

FZ!

]H!<>GF[[!<>GE[!<>:!5-<,.4<2!9.M28988989M387.5.C8181#.21J9(!AF8FJF!E[!<>GF[[!<>:!>2')'%!

9.M2898._:!>2')'%!9'!99(C9!E[!<>GF[[!<>:!>2')'%!9'19\8415:!>2')'%!9'1(6'8.M:!>2')'%!9'C1521(B'#:!>2')'%!9'C1521(B'#:!(),,-(4+-4.%!9'91(69:!>2')'%!9'4889(!.5_1524!Z][!<>:!5-<,.4<2!%33%. %(5%1+!9'4889(!.5_1524:!()(,%1(4-1!+) ;+'%!%1!3';5-1!99(_(147!^[[!<>:!5-<,.4<2!-.-/4(,%.(4+'%!99('!87\J.:!5-<,.4<2!99('995!^[[!<>G^[!<>:!5-<,.4<2!,%''45)'2!99('8815.!Z[[!<>:!,-)/.%!,-).!(-')+4-1!+) ;+'%!%1!(;5$%+C/-(%!

99('8815.!Z[[!<>:!(),,-(4+-4.%!(25;+'%!99('8815.!Z^[!<>:!,-)/.%!,-).!(-')+4-1!+) ;+'%!%1!(;5$%+C/-(%!

99('8815.!Z^[!<>:!(),,-(4+-4.%!99('8815.!][[!<>:!,-)/.%!,-).!(-')+4-1!+) ;+'%!%1!(;5$%+C/-(%!

99('8815.!][[!<>:!(),,-(4+-4.%!99('8815.!]:F!89\8!#.52!4154!4\#8.:!()(,%1(4-1!+) ;+'%!2/)'5-.2%!;)!<;'+4+-'!'4B)4/%!%+!;)!(-.+4+-'!

99('8815.!E[[!<>:!,-)/.%!,-).!(-')+4-1!+) ;+'%!%1!(;5$%+C/-(%!

99('8815.!E[[!<>:!(),,-(4+-4.%!99('8815.!^[[!<>:!5-<,.4<2!99('8815.!^[[!<>:!5-<,.4<2!%33%. %(5%1+!99('8815.!^[[!<>:!5-<,.4<2!-.-/4(,%.(4+'%!99('8815.!^[[!<>:!>2')'%!99('8815.!^[[!<>:!,-)/.%!,-).!(-')+4-1!+) ;+'%!%1!(;5$%+C/-(%!

99('8815.B'21J'5.#!^[[!<>GZ^[!<>:!5-<,.4<2!%33%. %(5%1+!!

99('8815.!Z[[[!<>:!5-<,.4<2!99('8815.!Z[[[!<>:!5-<,.4<2!%33%. %(5%1+!(25;+'%!99('8815.!Z[[[!<>:!,-)/.%!,-).!(-')+4-1!+) ;+'%!%1!(;5$%+C/-(%!

99('8815.!19\(2.4!Z[[[!<>:!(),,-(4+-4.%!99('889!Z[[!<>:!,-)/.%!,-).!(-')+4-1!+) ;+'%!%1!(;5$%+C/-(%!

99('889!Z[[!<>:!(),,-(4+-4.%!(25;+'%!99('889!Z^[!<>:!,-)/.%!,-).!(-')+4-1!+) ;+'%!%1!(;5$%+C/-(%!

99('889!Z^[!<>:!(),,-(4+-4.%!99('889!][[!<>:!,-)/.%!,-).!(-')+4-1!+) ;+'%!%1!(;5$%+C/-(%!

99('889!][[!<>:!(),,-(4+-4.%!99('889!E[[!<>:!,-)/.%!,-).!(-')+4-1!+) ;+'%!%1!(;5$%+C/-(%!

99('889!E[[!<>:!(),,-(4+-4.%!99('889!^[[!<>:!5-<,.4<2!99('889!^[[!<>:!5-<,.4<2!%33%. %(5%1+!99('889!^[[!<>:!>2')'%!99('889!^[[!<>:!,-)/.%!,-).!(-')+4-1!+) ;+'%!%1!(;5$%+C/-(%!

99('889!Z[[[!<>:!5-<,.4<2!

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

.__.81(615!8.9'128'`\.!E!89\8!#.52:!(-')+4-1!+) ;+'%!

.__.81(615!L[!<>:!,-)/.%!%33%. %(5%1+%!,-).!(-')+4-1!+) ;+'%!%1!(;5$%+!

.__.81(615!L[!<>:!(),,-(4+-4.%!.__.81(615!Z^[!<>:!,-)/.%!%33%. %(5%1+%!,-).!(-')+4-1!+) ;+'%!%1!(;5$%+!

.__.81(615!Z^[!<>:!(),,-(4+-4.%!.__.81(615!]^[!<>:!,-)/.%!%33%. %(5%1+%!,-).!(-')+4-1!+) ;+'%!%1!(;5$%+!

.__.81(615!E[[!<>:!(),,-(4+-4.%!.__.81(615!^[[!<>:!5-<,.4<2!.__.81(615!^[[!<>:!5-<,.4<2!%33%. %(5%1+!(25;+'%!.__.81(61599'4!^[[!<>:!5-<,.4<2!-.-/4(,%.(4+'%!.__.81(615B'21J'5.#!^[[!<>G][[!<>!:!5-<,.4<2!%33%. %(5%1+!!

.__.81(615!Z!>:!5-<,.4<2!%33%. %(5%1+!.__.81(615!B'21J'5.!#:!5-<,.4<2!%33%. %(5%1+!(25;+'%!!

.__.81(615!#99.'5.:!5-<,.4<2!%33%. %(5%1+!(25;+'%!.87.981_.'5.:!5-<,.4<2!.86'M!87\J.:!5-<,.4<2!,%''45)'2!.1!5-).(!/A;..)+!/%!5-<<%.54;'4(;+4-1!

.\#1(382948'8'5.!19\(2.4:!(),,-(4+-4.%!.\#1(382948'8'5.!.5_1524:!(),,-(4+-4.%!J8;.;52+;<-'!][[!<>,!

.\#1(382948'8'5.!59\88'44954:!(),,-(4+-4.%!.M'99(!^[[!<>G^[!<>:!5-<,.4<2!.M'99(!^[[!<>G^[!<>:!5-<,.4<2!%33%. %(5%1+!.M81599(!^[[!<>:!,-)/.%!,-).!(-')+4-1!+) ;+'%!%1!(;5$%+C/-(%!

.M81599M!^[[!<>:!5-<,.4<2!.M81599M!^[[!<>:!5-<,.4<2!%33%. %(5%1+!(25;+'%!_.A81(6'5.:!5-<,.4<2!(25;+'%!

Page 42: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

!

F]!

!_.A8.#29(!Z]^!<>:!5-<,.4<2!/4(,%.(4+'%!_.A8.#29(!]^[!<>:!5-<,.4<2!/4(,%.(4+'%!_.A8.#29(!19\(2.4:!(),,-(4+-4.%!_.A8.#29(!.5_1524:!(),,-(4+-4.%!_.A8.#29(!59\88'44954:!(),,-(4+-4.%!_.A8'81M!L[!<>:!(),,-(4+-4.%!_.A8'81M!ZH[!<>:!(),,-(4+-4.%!_.8B.M!.5_1524:!>.;1)'2!%1!(;5$%+!!

_.8B.M!87\J.:!>2')'%!!_.8B.M!4154!4\#8.:!>.;1)'2!,-).!(-')+4-1!+) ;+'%!%1!(;5$%+!!

_.8B.M:!>.;1)'2(!%1!(;5$%+(!!

_(\9'2.#!.212!68'881(:!>.;1)'2(!,-).!(-')+4-1!+) ;+'%!%1!(;5$%+C/-(%!

6194.91(!^[[!<>:!(),,-(4+-4.%!6194.91(!#99.'5.:!5-<,.4<2!6.(\J1('5.!J1\!8181#.21J9(,:!>2')'%!6.(\8815.!^[[!<>:!>2')'%!63594814J'5.!E[[!<>:!5-<,.4<2!7.M168'8!B'21J'5.!#:!5-<,.4<2!!

7\J.M!_9\85'.8:!>2')'%!7\J.M!87\J.:!5-<,.4<2!%+!>2')'%! 'M88'J!EH:^!<>GE]^!<>:!5-<,.4<2!,%''45)'2!C('81(!7[!<>G]!<':!(-')+4-1!+) ;+'%!C('81(!#99.'5.!E[[!<>G]^!<>:!5-<,.4<2!C('81(!^[[!<>:!5-<,.4<2!(25;+'%!C('81(!#99.'5.!7[[!<>G^[!<>:!5-<,.4<2!(1J1('5.:!>2')'%!(1J1('5.:!(),,-(4+-4.%!('A8199(!^[[!<>:!5-<,.4<2!(25;+'%!('A8199(!#1_.'5.!^[[!<>G^[!<>:!5-<,.4<2!%33%. %(5%1+!(25;+'%!

('A8199(!#1_.'5.!^[[!<>G^[!<>:!5-<,.4<2!(25;+'%!('59'(15.!F[[!<>G]^!<>:!5-<,.4<2!('59'(15.!7[[!<>GEL!<>:!5-<,.4<2!J1(6'4!^[[!<>:!5-<,.4<2!J1(6'4!^[[!<>:!>2')'%!J1('995.:!5-<,.4<2!(25;+'%!J.54\94.93(:!5-<,.4<2!,%''45)'2!J'681(6'5.:!>2')'%!J'681(6'5.:!(-')+4-1!+) ;+'%!J9J'529J:!>2')'%!5.9#'2815:!,-)/.%!,-).!(-')+4-1!+) ;+'%!%1!(;5$%+!59B1#.29(!J148'8'5.!8181#.21J9(,:!5-<,.4<2!!

981(615!Z]^!<>GZ:]^!<':!(-')+4-1!+) ;+'%!981(615!E]^!<>:!5;,()'%!815199(!Z]^!<>:!(),,-(4+-4.%!

815199(!4154!4\#8.!]:F!89\8!#.52:!()(,%1(4-1!+) ;+'%!2/)'5-.2%!;)!<;'+4+-'!%+!;)!(-.+4+-'!

815199(!]^[!<>:!(),,-(4+-4.%!815199(!^[[!<>:!5-<,.4<2!%33%. %(5%1+!(25;+'%!815199(!^[[!<>:!5-<,.4<2!,%''45)'2!(25;+'%!815199(!#1_.'5.!^[[!<>G^[!<>:!5-<,.4<2!%33%. %(5%1+!(25;+'%!

815199(!#1_.'5.!^[[!<>G^[!<>:!5-<,.4<2!,%''45)'2!(25;+'%!

815199(!Z[[[!<>:!(),,-(4+-4.%!815199(!#99.'5.!.__.8B.4#.52:!5-<,.4<2!%33%. %(5%1+!

8181#.21J9(!1(J\4!^[[!<>:!5-<,.4<2!8181#.21J9(!1(J\4!Z!>:!5-<,.4<2!8181#.21J9(!18896!^[[!<>:!5-<,.4<2!8181#.21J9(!18896!^[[!<>:!5-<,.4<2!%33%. %(5%1+!(25;+'%!

8181#.21J9(!18896!^[[!<>:!,-)/.%!,-).!(-')+4-1!+) ;+'%!%1!(;5$%+C/-(%!

8181#.21J9(!18896!Z!>:!5-<,.4<2!8181#.21J9(!18896!Z!>:!5-<,.4<2!%33%. %(5%1+!(25;+'%!

8181#.21J9(!A'9_'9.4!^[[!<>:!5-<,.4<2!8181#.21J9(!A'961(.5'`\.!^[[!<>:!>.;1)'2(!,-).!()(,%1(4-1!+) ;+'%!%1!(;5$%+!/-(%!

8181#.21J9(!A'961815!^[[!<>:!5-<,.4<2!8181#.21J9(!A'961815!^[[!<>:!5-<,.4<2!%33%. %(5%1+!

8181#.21J9(!A'961815!^[[!<>:!>2')'%!8181#.21J9(!A'961815!Z!>:!5-<,.4<2!8181#.21J9(!A'961815!Z!>:!5-<,.4<2!%33%. %(5%1+!(25;+'%!

8181#.21J9(!AJ4!^[[!<>:!5-<,.4<2!8181#.21J9(!AJ4!^[[!<>:!5-<,.4<2!%33%. %(5%1+!(25;+'%!

8181#.21J9(!AJ4!^[[!<>:!5-<,.4<2!,%''45)'2!8181#.21J9(!AJ4!Z!>:!5-<,.4<2!%33%. %(5%1+!8181#.21J9(!AJ4!Z!>:!5-<,.4<2!,%''45)'2!8181#.21J9(!#1_.'5.!27.818('M!^[[!<>G^[!<>:!5-<,.4<2!%33%. %(5%1+!

8181#.21J9(!#1_.'5.!27.818('M!^[[!<>G^[!<>:!5-<,.4<2!,%''45)'2!

8181#.21J9(!#.7.(!8718J1!^[[!<>:!5-<,.4<2!D!5.-B)%.!

8181#.21J9(!#.7.(!8718J1!Z!>:!5-<,.4<2!D!5.-B)%.!8181#.21J9(!#((!8718J1!^[[!<>:!5-<,.4<2!D!5.-B)%.!8181#.21J9(!#99.'5.!1(J\4!^[[!<>GE[!<>:!5-<,.4<2!%33%. %(5%1+!(25;+'%!

8181#.21J9(!#99.'5.!18896!F[[!<>G][!<>:!5-<,.4<2!(25;+'%!

8181#.21J9(!#99.'5.!18896!^[[!<>GE[!<>:!5-<,.4<2!%33%. %(5%1+!(25;+'%!

8181#.21J9(!#99.'5.!A'961(.5'`\.!7[[!<>G^[!<>:!5-<,.4<2!

8181#.21J9(!#99.'5.!A'961815!^[[!<>GE[!<>:!5-<,.4<2!%33%. %(5%1+!(25;+'%!

8181#.21J9(!#99.'5.!AJ4!^[[!<>GE[!<>:!5-<,.4<2!%33%. %(5%1+!(25;+'%!

8181#.21J9(!#99.'5.!AJ4!^[[!<>GE[!<>:!5-<,.4<2!,%''45)'2!

8181#.21J9(!#99.'5.!A8'429(CJ3.84!4`\'AA!Z]!<>G[:7!<>G<':!()(,%1(4-1!+) ;+'%!

8181#.21J9(!#99.'5.!A8'429(CJ3.84!4`\'AA!]^!

Page 43: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

!

FE!

<>GZ:F"^!<>G<':!()(,%1(4-1!+) ;+'%!8181#.21J9(!#99.'5.!.6!^[[!<>GE[!<>:!5-<,.4<2!%33%. %(5%1+!(25;+'%!

8181#.21J9(!#99.'5.!6!61J!^[[!<>GE[!<>:!5-<,.4<2!%33%. %(5%1+!(25;+'%!

8181#.21J9(!#99.'5.!'B1M!^[[!<>GE[!<>:!5-<,.4<2!%33%. %(5%1+!(25;+'%!

8181#.21J9(!#99.'5.!J.8#C!^[[!<>GE[!<>:!5-<,.4<2!%33%. %(5%1+!(25;+'%!

8181#.21J9(!#99.'5.!41599D!^[[!<>GE[!<>:!5-<,.4<2!%33%. %(5%1+!(25;+'%!

8181#.21J9(!#99.'5.!2.B1!^[[!<>GE[!<>:!5-<,.4<2!%33%. %(5%1+!(25;+'%!

8181#.21J9(!#99.'5.!27.818('M:!5-<,.4<2!8181#.21J9(!#99.'5.!\F8F4F1F:!5-<,.4<2!%33%. %(5%1+!8181#.21J9(!91C921!8718J!^[[!<>:!5-<,.4<2!/4(,%.(4+'%!

8181#.21J9(!.!8718J1!^[[!<>:!5-<,.4<2!%33%. %(5%1+!

8181#.21J9(!.__.8B.4#.52!\841!EE[!<>:!5-<,.4<2!%33%. %(5%1+!

8181#.21J9(!.__.8B.4#.52!\841!77[!<>:!5-<,.4<2!%33%. %(5%1+!

8181#.21J9(!.6!^[[!<>:!5-<,.4<2!8181#.21J9(!.6!^[[!<>:!5-<,.4<2!%33%. %(5%1+!8181#.21J9(!.6!^[[!<>:!>2')'%!8181#.21J9(!.6!Z!>:!5-<,.4<2!8181#.21J9(!.6!Z[[[!<>:!5-<,.4<2!%33%. %(5%1+!(25;+'%!

8181#.21J9(!.2738718J!Z]^!<>:!<45.->.;1)'%(!%1!(;5$%+!

8181#.21J9(!.2738718J!]^[!<>:!<45.->.;1)'%!%1!(;5$%+!

8181#.21J9(!.2738718J!^[[!<>:!<45.->.;1)'%(!%1!(;5$%+!

8181#.21J9(!6!61J!^[[!<>:!5-<,.4<2!8181#.21J9(!6!61J!Z!>:!5-<,.4<2!%33%. %(5%1+!(25;+'%!

8181#.21J9(!6122._944.!^[[!<>:!5-<,.4<2!D!5.-B)%.!8181#.21J9(!68\5.5271(!Z!>:!5-<,.4<2!8181#.21J9(!'B1M!^[[!<>:!5-<,.4<2!8181#.21J9(!J.8#C!^[[!<>:!5-<,.4<2!8181#.21J9(!J.8#C!^[[!<>:!5-<,.4<2!%33%. %(5%1+!8181#.21J9(!J.8#C!^[[!<>:!>2')'%!8181#.21J9(!J.8#C!Z[[[!<>:!5-<,.4<2!%33%. %(5%1+!(25;+'%!

8181#.21J9(!J.8#C!6.5.8'#4!_815#.!79(9'56!^[[!<>:!5-<,.4<2!(25;+'%!

8181#.21J9(!J9592!59\88'44954!H^!<>:!>.;1)'2!,-).!()(,%1(4-1!+) ;+'%!%1!(;5$%+!

8181#.21J9(!J9592!.5_1524!Z^[!<>:!>.;1)'2!,-).!()(,%1(4-1!+) ;+'%!%1!(;5$%+!

8181#.21J9(!8896818718J!Z]^!<>:!5-<,.4<2!/4(,%.(4+'%!

8181#.21J9(!8896818718J!]^[!<>:!5-<,.4<2!/4(,%.(4+'%!

8181#.21J9(!`\1('J.9!^[[!<>:!5-<,.4<2!8181#.21J9(!815A1M3!Z!>:!5-<,.4<2!8181#.21J9(!812'9!^[[!<>:!5-<,.4<2!(25;+'%!8181#.21J9(!812'98718J!^[[!<>:!5-<,.4<2!%33%. %(5%1+!

8181#.21J9(!812'98718J!^[[!<>:!5-<,.4<2!(25;+'%!8181#.21J9(!812'98718J!^[[!<>:!>2')'%!

8181#.21J9(!812'98718J!Z[[[!<>:!5-<,.4<2!8181#.21J9(!812'98718J!Z[[[!<>:!5-<,.4<2!%33%. %(5%1+!(25;+'%!

8181#.21J9(!886!^[[!<>:!5-<,.4<2!8181#.21J9(!886!^[[!<>:!5-<,.4<2!%33%. %(5%1+!8181#.21J9(!886!^[[!<>:!>2')'%!8181#.21J9(!41599D!^[[!<>:!5-<,.4<2!8181#.21J9(!41599D!^[[!<>:!5-<,.4<2!%33%. %(5%1+!8181#.21J9(!41599D!^[[!<>:!5-<,.4<2!%33%. %(5%1+!(25;+'%!

8181#.21J9(!41599D!^[[!<>:!>2')'%!8181#.21J9(!41599D!#954.'(!^[[!<>:!5-<,.4<2!8181#.21J9(!41599D!Z!>:!5-<,.4<2!%33%. %(5%1+!(25;+'%!

8181#.21J9(!41599D!Z!>:!5-<,.4<2!(25;+'%!8181#.21J9(!4159_'C43527.(1A9!92#!^[!<>:!,-)/.%!%33%. %(5%1+%!%1!(;5$%+C/-(%!

8181#.21J9(!4159_'C43527.(1A9!92#!Z]^!<>:!,-)/.%!%33%. %(5%1+%!%1!(;5$%+C/-(%!

8181#.21J9(!4159_'C43527.(1A9!92#!]^[!<>:!,-)/.%!%33%. %(5%1+%!%1!(;5$%+C/-(%!

8181#.21J9(!4.2!^[[!<>:!5-<,.4<2!8181#.21J9(!4.2!^[[!<>:!5-<,.4<2!%33%. %(5%1+!8181#.21J9(!4J'27C('5.!A..#71J!.5_152!.2!59\88'4495!]:F!89\8!#.52:!()(,%1(4-1!+) ;+'%!

8181#.21J9(!2.B1!^[[!<>:!5-<,.4<2!8181#.21J9(!2.B1!^[[!<>:!5-<,.4<2!%33%. %(5%1+!8181#.21J9(!2.B1!Z!>:!5-<,.4<2!8181#.21J9(!2.B1!Z!>:!5-<,.4<2!%33%. %(5%1+!(25;+'%!8181#.21J9(!27.818('M!^[[!<>:!5-<,.4<2!8181#.21J9(!27.818('M!^[[!<>:!,-)/.%!,-).!(-')+4-1!+) ;+'%!%1!(;5$%+C/-(%!

8181#.21J9(!298(15!^[[!<>:!5-<,.4<2!8181#.21J9(!B.3895!_89J.52!^[[!<>:!>2')'%!8181#.21J9(!6'527898!^[[!<>:!5-<,.4<2!8181#.21J9(!6'527898!Z!>:!5-<,.4<2!8181#.21J9(!6'527898!Z!>:!5-<,.4<2!%33%. %(5%1+!(25;+'%!

8181#.21J9(!D39\4!^[[!<>:!5-<,.4<2!8181#.21J9(!D39\4!Z!>:!5-<,.4<2!8181#.21J9(G#'5.9(.!J9592!][[!<>GH[!<>:!(),,-(4+-4.%!

8181(39#!^[!<>:!'=-,$4'4(;+!-.;'!8181(39#!Z]^!<>:!'=-,$4'4(;+!-.;'!8181(39#!]^[!<>:!'=-,$4'4(;+!-.;'!8181(39#!^[[!<>:!'=-,$4'4(;+!-.;'!8.#29CA895#9(!59\88'44954:!(),,-(4+-4.%!8.8_1(615!Z[!<>G<':!(-')+4-1!,-).!,%.3)(4-1!8.8_1(615!59\88'44954!.2!.5_1524!Z[!<>G<':!(-')+4-1!,-).!,%.3)(4-1!

8.8\A98.!87'5'2.:!,-)/.%!,-).!(-')+4-1!+) ;+'%!%1!(;5$%+C/-(%!!

889521(6'5.:!5-<,.4<2!889521(6'5.:!5-<,.4<2!%33%. %(5%1+!88989_15:!5-<,.4<2!8381M!Z[[!<>:!(),,-(4+-4.%!8381M!]^[!<>:!(),,-(4+-4.%!8381M!7[[!<>:!(),,-(4+-4.%!87'51#23(:!,-)/.%!,-).!(-')+4-1!+) ;+'%!

Page 44: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

!

FF!

!

87'5'4'(:!5-<,.4<2!87'59_.A81(!B.8B.'5.!J'.(!#'2895:!,-)/.%!,-).!(-')+4-1!+) ;+'%!%1!(;5$%+C/-(%!!

87'59_.A81(:!>2')'%!!

87\J168'8:!5-<,.4<2!8'5\8.(:!5-<,.4<2!(25;+'%!8'5\215:!5-<,.4<2!(25;+'%!8'5\215:!()(,%1(4-1!+) ;+'%!418'995!^[[!<>:!5-<,.4<2!4.918.5.!.5_1524!E^[!<>:!(),,-(4+-4.%!4.918.5.!19\(2.4!7[[!<>:!(),,-(4+-4.%!4.918.5.:!>2')'%!

4\8199(:!5-<,.4<2!4\889J1('5.:!(),,-(4+-4.%!C!.1!5-).(!/A;..)+!/%!5-<<%.54;'4(;+4-1!

4\8894'821(!ZF[!<>G^[!<>:!(),,-(4+-4.%!4\8894'821(!E^[!<>G^[!<>:!(),,-(4+-4.%!4\8894'821(!19\(2.4:!(),,-(4+-4.%!21(B'99(!E[!<>GF[[!<>:!>2')'%!27.'59(:!(-')+4-1!+) ;+'%!29(.815.!^[[!<>:!5-<,.4<2!%33%. %(5%1+!(25;+'%!28987'8.4!#9J894.!19\(2.4:!(),,-(4+-4.%!28987'8.4!#9J894.!.5_1524:!(),,-(4+-4.%!28987'8.4!#9J894.!59\88'44954:!(),,-(4+-4.%!B.619.'5.!19\(2.4:!(),,-(4+-4.%!!

B.81(3995:!5-<,.4<2!D1(9'18!EH:^!<>GE]^!<>:!5-<,.4<2!,%''45)'2!

\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!!!!!

J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!!!!!

(;!,.4(%!/%!5%!<2/45;<%1+!,;.! -4%!.%5+;'%!%(+!,-((4+'%F!

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

`\198141!]>:!,-)/.%!(-')+4-1!.%5+;'%!!<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

1!5%!*-).:!4'!10%%4(+%!,;(!/%!.4(B)%!$2<-'=+4B)%!4/%1+4342!5$%&!'%(!()*%+(!/23454%1+(!%1!6789!,-).!'%(!(,254;'4+2(!5-1+%1;1+!/)!!814!;/<414(+.2%(!,;.! -4%!.%5+;'%F!1!1-+%.!B)%!'%!814:!)+4'4(2!,;.!'%!,;((2!/;1(!'%!+.;4+%<%1+!/%!';!+)+%.5)'-(%:!;!/-112!'4%)!D!/%)%!5;(!/0$2<-'=(%!5$%&!/%(!()*%+(!/23454+;4.%(!%1!6789!J5;(!.;,,-.+2(!/;1(!';!'4++2.;+).%!41+%.1;+4-1;'%,F!

(;!,.4(%!/%!5%!<2/45;<%1+!,;.! -4%!.%5+;'%!%(+!,-((4+'%F!

Page 45: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

!

F^!

925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!,;.+45)'4/.%,!%1!.;4(-1!/%!,;.+45)'4/.%,!%1!.;4(-1!/%!,;.+45)'4/.%,!%1!.;4(-1!/%!,;.+45)'4/.%,!%1!.;4(-1!/%!

'A;,,;.+%1;15%!D!)1%!3;<4''%!'A;,,;.+%1;15%!D!)1%!3;<4''%!'A;,,;.+%1;15%!D!)1%!3;<4''%!'A;,,;.+%1;15%!D!)1%!3;<4''%!,$;.<;5-'->4B)%!D!.4(B)%,$;.<;5-'->4B)%!D!.4(B)%,$;.<;5-'->4B)%!D!.4(B)%,$;.<;5-'->4B)%!D!.4(B)%!!!!

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

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

(%(!;'+%.1;+4 %(!+$2.;,%)+4B)%(!;)!(%41!/%!5%++%!3;<4''%!1%!(-1+!,;(!+-+;'%<%1+!%%%<,+%(!/A)1!.4(B)%!/A$2<-'=(%!5$%&!'%(!()*%+(!/23454+;4.%(!%1!6789F!

''!%(+!4<,-.+;1+!/%!,.2 %14.! -+.%!<2/%541!(4! -)(!J-)!)1!<%<+.%!/%! -+.%!3;<4''%,!)+%(!;++%41+!/A)1!/23454+!%1!6')5-(%C7C8$-(,$;+%!92($=/.->21;(%!5;.!)1!.4(B)%!/A$2<-'=(%!J/%(+.)5+4-1!/%(!>'-+)'%(!.-)>%(,!%%4(+%!; %5!/A;)+.%(!<2/45;<%1+(!/%!';!<)<%!3;<4''%!B)%!';!,23'-%;541%F!

925-1(%4''2%!%1!.;4(-1!/A)1!,;((;>%!925-1(%4''2%!%1!.;4(-1!/A)1!,;((;>%!925-1(%4''2%!%1!.;4(-1!/A)1!,;((;>%!925-1(%4''2%!%1!.;4(-1!/A)1!,;((;>%!(=(+2<4B)%!,.-+;+'%(=(+2<4B)%!,.-+;+'%(=(+2<4B)%!,.-+;+'%(=(+2<4B)%!,.-+;+'%!!!!

(%(!(,254;'4+2(!5-1+%1;1+!/%!';!,$21;&-1%!(-1+!()(5%,+4+'%(!/0%1+.;R1%.!)1%!$2<-'=(%!;4>)?!5$%&!'%(!()*%+(!,-.+%).(!/0)1!/23454+!%1&=<;+4B)%!%1!6789F!!8;.!,.4154,%:!';!,.%(5.4,+4-1!/-4+!/-15!,.%1/.%!%1!5-<,+%!5%!.4(B)%:!%+!'%!.%5-).(!D!)1%!;'+%.1;+4 %!+$2.;,%)+4B)%:!(4!%''%!%%4(+%:!%(+!.%5-<<;1/2%F!44!';!,.%(5.4,+4-1!/%!5%!<2/45;<%1+!%(+!125%((;4.%:!';!(). %1)%!/0)1%!$2<-'=(%!2 %1+)%''%!/% .;!)+.%!/2,4(+2%F!

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

1)! )!/%(!&-1%(!%+!/%(!5-1/4+4-1(!/A;,,'45;+4-1:!'%!,;((;>%!(=(+2<4B)%!/%!5%++%!()+(+;15%!%(+!,.-+;+'%F!

''!%(+!4<,-.+;1+!/%!,.2 %14.! -+.%!<2/%541!(4! -)(!J-)!)1!<%<+.%!/%! -+.%!3;<4''%,!)+%(!;++%41+!/A)1!/23454+!%1!6')5-(%C7C8$-(,$;+%!92($=/.->21;(%!5;.!)1!.4(B)%!/A$2<-'=(%!J/%(+.)5+4-1!/%(!>'-+)'%(!.-)>%(,!%%4(+%!; %5!';!,$21;&-1%!%1!;,,'45;+4-1!'-5;'%F!

8._(1#'5.!F[[!<>:!5-<,.4<2!,%''45)'2!(25;+'%!8._(1#'5.!F[[!<>:!(-')+4-1!41*%5+;+'%!'B!%1!,%.3)(4-1!8._(1#'5.!F[[!<>GZ]^!<':!(-')+4-1!41*%5+;+'%!,-).!,%.3)(4-1!%1!,-5$%!

8._(1#'5.!J959994.!F[[!<>:!5-<,.4<2!%1.-+2!

A8\(.M:!,-<<;/%!7.#:!,-<<;/%!,-).!;,,'45;+4-1!5)+;12%!%+!1;(;'%!7.#:!,-<<;/%!.%5+;'%!

9B\(.4!4.99C7.J94212'`\.4!9\!99#2.\8!I9\B.:!- )'%!

Page 46: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

!

F7!

\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!!!!!

J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!!!!!

(;!,.4(%!/%!5%!<2/45;<%1+!,;.! -4%!;).45)';4.%!%(+!,-((4+'%F!

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

92'81M:!(-')+4-1!,-).!41(+4'';+4-1!;).45)';4.%! 92'81M:!(-')+4-1!,-).!,)' 2.4(;+4-1!;).45)';4.%!

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

1!5%!*-).:!4'!10%%4(+%!,;(!/%!.4(B)%!$2<-'=+4B)%!4/%1+4342!5$%&!'%(!()*%+(!/23454%1+(!%1!6789!,-).!'%(!(,254;'4+2(!5-1+%1;1+!/%!';!,$21;&-1%!;/<414(+.2%(!,;.! -4%!;).45)';4.%F!!

(;!,.4(%!/%!5%!<2/45;<%1+!,;.! -4%!;).45)';4.%!%(+!,-((4+'%F!

\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!

/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!!!!!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!!!!!

(;!,.4(%!/%!5%!<2/45;<%1+!%(+!,-((4+'%F!

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

A\21D9('9'5.!Z[[!<>:!5-<,.4<2!%1.-+2!!A\21D9('9'5.!]^[!<>:!(),,-(4+-4.%!!#18\99(!E[[<>:!>2')'%!#18\99(!^!89\8!#.52:!>%'!9.M2818'5.!87.53(A\21D95.:!,-<<;/%!

87.53(A\21D95.!59B182'4!8718J1!][[!<>:!5-<,.4<2!%1.-+2!

87.53(A\21D95.!59B182'4!8718J1!]^[!<>:!(),,-(4+-4.%!

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

1!5%!*-).:!4'!10%%4(+%!,;(!/%!.4(B)%!$2<-'=+4B)%!4/%1+4342!5$%&!'%(!()*%+(!/23454%1+(!%1!6789!,-).!';!,$21='+)+;&-1%F!!

(;!,.4(%!/%!5%!<2/45;<%1+!%(+!,-((4+'%F!

Page 47: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

!

FH!

\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!

/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!!!!!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!!!!!

(;!,.4(%!/%!5%!<2/45;<%1+!%(+!,-((4+'%F!

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

9'C73915!Z[[!<>:!5-<,.4<2!(25;+'%! 9'(152'5!]^[<>G^<':!(-')+4-1!41*%5+;+'%!

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

1!5%!*-).:!4'!10%%4(+%!,;(!/%!.4(B)%!$2<-'=+4B)%!4/%1+4342!5$%&!'%(!()*%+(!/23454%1+(!%1!6789!,-).!';!,$21=+-T1%F!!

(;!,.4(%!/%!5%!<2/45;<%1+!%(+!,-((4+'%F!

925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!

,;.+45)'4/.%,!%1!.;4(-1!/%!.;.%(!5;(!,;.+45)'4/.%,!%1!.;4(-1!/%!.;.%(!5;(!,;.+45)'4/.%,!%1!.;4(-1!/%!.;.%(!5;(!,;.+45)'4/.%,!%1!.;4(-1!/%!.;.%(!5;(!-+(%. 2(!/A$2<-'=(%!;4>)?-+(%. 2(!/A$2<-'=(%!;4>)?-+(%. 2(!/A$2<-'=(%!;4>)?-+(%. 2(!/A$2<-'=(%!;4>)?!!!!

#$%&!'%(!()*%+(!,-.+%).(!/0)1!/23454+!%1&=<;+4B)%!%1!6789:!/%!+./(!.;.%(!5;(!/A$2<-'=(%!;4>)?!-1+!2+2!.;,,-.+2(!'-.(!/%!'0;/<414(+.;+4-1!/%!,$=+-<21;/4-1%F!''!%(+!/-15!4<,-.+;1+!/%!,.%1/.%!%1!5-<,+%!,-).!5$;B)%!,;+4%1+:!'%!/;1>%.!/A$2<-'=(%!%+!'%!+212345%!,-+%1+4%'!;++%1/)!/)!+.;4+%<%1+F!

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

4;1(!-+*%+!

B-)(!/% %&!413-.<%.! -+.%!<2/%541!(4! -)(!J-)!)1!<%<+.%!/%! -+.%!3;<4''%,!)+%(!;++%41+!/A)1!/23454+!%1!6')5-(%C7C8$-(,$;+%!92($=/.->21;(%!5;.!)1!.4(B)%!/A$2<-'=(%!J/%(+.)5+4-1!/%(!>'-+)'%(!.-)>%(,!%%4(+%!; %5!';! 4+;<41%!CZF!

J\(2'B'21J'5.4!89#7.!5'#79(14:!5-<,.4<2!%33%. %(5%1+!!

4\881935.:!5-<,.4<2!%33%. %(5%1+!!

B'21('8'9.!19\(2.4:!2<)'(4-1!41*%5+;+'%!,-).!,%.3)(4-1!B'21('8'9.!.5_1524:!2<)'(4-1!41*%5+;+'%!,-).!,%.3)(4-1!B'21J'5.!CZ!][!<>G<':!2<)'(4-1!+) ;+'%!%1!>-)++%(!B'21J'5.!CZ!9.(168156.!][!<>G<':!(-')+4-1!+) ;+'%:!

>-)++%(!B'21J'5.!CZ!9.(168156.!^[!<>GZ!<':!(-')+4-1!41*%5+;+'%:!;<,-)'%!

B'21J'5.!CZ!89#7.!Z[!<>:!5-<,.4<2!%1.-+2!D!5.-B)%.!B'21J'5.!CZ!89#7.!Z[!<>GZ!<':!(-')+4-1!+) ;+'%!%+!41*%5+;+'%!

B'21J'5.!CZ!89#7.!]!<>G[:]!<'!59\88'44954:!(-')+4-1!+) ;+'%!%+!41*%5+;+'%!

B'21J'5.!CZ!89#7.!][!<>GZ!<':!2<)'(4-1!41*%5+;+'%!

Page 48: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

!

FL!

925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!

,;.+45)'4/.%,!%1!.;4(-1!/A)1!.4(B)%!,;.+45)'4/.%,!%1!.;4(-1!/A)1!.4(B)%!,;.+45)'4/.%,!%1!.;4(-1!/A)1!.4(B)%!,;.+45)'4/.%,!%1!.;4(-1!/A)1!.4(B)%!,-+%1+4%'!/%!<2+$2<->'-+412<4%,-+%1+4%'!/%!<2+$2<->'-+412<4%,-+%1+4%'!/%!<2+$2<->'-+412<4%,-+%1+4%'!/%!<2+$2<->'-+412<4%!!!!

.1!.;4(-1!/)!.4(B)%!,-+%1+4%'!/%!<2+$2<->'-+412<4%:!4'!%(+!.%5-<<;1/2!4,!/%!10)+4'4(%.!';!,.4'-5;T1%!B)0%1!<4'4%)!$-(,4+;'4%.!5$%&!'%!1-) %;)C12!%+!'%!,.2<;+).2!%+!44,!/%!1%!,;(!)+4'4(%.!';!,.4'-5;T1%!5$%&!'%!1-)..4((-1!/%!<-41(!/%!E!<-4(!;=;1+!)1!/23454+!%1!6789!5-11)!-)!()(,%5+2F!

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

4;1(!-+*%+!

(;!,.4'-5;T1%!1%!/-4+!,;(!)+.%!)+4'4(2%!5$%&!'%!1-)..4((-1!/%!<-41(!/%!E!<-4(!;=;1+!)1!/23454+!%1!6789!5-11)!-)!()(,%5+2F!''!%(+!/-15!4<,-.+;1+!/%!,.2 %14.! -+.%!<2/%541!(4! -)(:! -+.%!5-1*-41+!J-)!)1!<%<+.%!/%! -(!3;<4''%(!.%(,%5+4 %(,!)+%(!;++%41+(!/A)1!/23454+!%1!6')5-(%C7C8$-(,$;+%!92($=/.->21;(%F!

15.49.8J!^!S:!5./<%!.J(1!^!89\8!#.52:!5./<%!.J(1812#7!^!89\8!#.52:!,;1(%<%1+!;/$2(43!5)+;12!('99#1'5.!88'(9#1'5.!A'961815!^!S:!5./<%!

('99#1'5.G88'(9#1'5.!16\.22152!^!S:!5./<%!('99#1'5.G88'(9#1'5.!'99!^!S:!5./<%!981`'M!:!>%'!,2.4-/-1+;'!

\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!

/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!!!!!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!!!!!

(;!,.4(%!/%!5%!<2/45;<%1+!%(+!,-((4+'%F!

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

A.5.J'9.!^[[!<>:!5-<,.4<2!(25;+'%! !

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

1!5%!*-).:!4'!10%%4(+%!,;(!/%!.4(B)%!$2<-'=+4B)%!4/%1+4342!5$%&!'%(!()*%+(!/23454%1+(!%1!6789!,-).!'%(!(,254;'4+2(!5-1+%1;1+!/)!!,.-+21254/%F!!

(;!,.4(%!/%!5%!<2/45;<%1+!%(+!,-((4+'%F!

Page 49: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

!

F"!

\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!!!!!

J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!!!!!

(;!,.4(%!/%!5%!<2/45;<%1+!%(+!,-((4+'%F!

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

1!A!':!2<)'(4-1!,-).!;,,'45;+4-1!'-5;'%! !

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

1!5%!*-).:!4'!10%%4(+%!,;(!/%!.4(B)%!$2<-'=+4B)%!4/%1+4342!5$%&!'%(!()*%+(!/23454%1+(!%1!6789!,-).!'%(!(,254;'4+2(!5-1+%1;1+!/)!,.-,='/1%!>'=5-'F!!

(;!,.4(%!/%!5%!<2/45;<%1+!%(+!,-((4+'%F!

\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!

/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!!!!!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!!!!!

(;!,.4(%!/%!5%!<2/45;<%1+!%(+!,-((4+'%F!

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

J1(1895.:!5-<,.4<2!,%''45)'2!J1(1895.!7]:^!<>G]^!<>!.5_1524:!5-<,.4<2!,%''45)'2!5981(\:!>2')'%!!

81(\98'5.!Z[[!<>:!5-<,.4<2!(25;+'%!!41B18'5.:!5-<,.4<2!,%''45)'2!!

!

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

1!5%!*-).:!4'!10%%4(+%!,;(!/%!.4(B)%!$2<-'=+4B)%!4/%1+4342!5$%&!'%(!()*%+(!/23454%1+(!%1!6789!,-).!'%(!(,254;'4+2(!5-1+%1;1+!/)!!,.->);14'F!!

(;!,.4(%!/%!5%!<2/45;<%1+!%(+!,-((4+'%F!

Page 50: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

!

^[!

\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!

/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!!!!!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!!!!!

(;!,.4(%!/%!5%!<2/45;<%1+!%(+!,-((4+'%F!

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

_154'918:!5-<,.4<2!B);/.4(25;+'%!!

_154'918:!(-')+4-1!41*%5+;+'%!'J!%1!;<,-)'%!!

J1(9#'9.!^[!<>!5-<,.4<2!!

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

(;!,=.4<2+$;<41%!1%!(%<+'%!,;(!)+.%!/4.%5+%<%1+!.%(,-1(;+'%!/0;12<4%!$2<-'=+4B)%F!(%(!5;(!.%5%1(2(!/;1(!';!'4++2.;+).%!(). 4%11%1+!+-)*-).(!%1!;((-54;+4-1!; %5!)1!()'3;<4/%:!()+(+;15%!/-1+!'0%33%+!-%=/;1+!;)!14 %;)!/%(!2.=+$.-5=+%(!%(+!5-11)F!

(;!,.4(%!/%!5%!<2/45;<%1+!%(+!,-((4+'%F!

\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!

/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!!!!!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!!!!!

(;!,.4(%!/%!5%!<2/45;<%1+!%(+!,-((4+'%F!

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

#189'9`\'5.!Z77!<>:!5-<,.4<2!(25;+'%!#189'9`\'5.!(!8:!>2')'%!D!'4+2.;+4-1!,.-'-1>2%!#189'9`\'5.!(F8F!]^[!<>:!5-<,.4<2!(25;+'%!D!'4+2.;+4-1!,.-'-1>2%!!

9829`\'5'9'5.:!5-<,.4<2!D!'4+2.;+4-1!,.-'-1>2%!!`\'5'J1M!Z]^!<>:!5-<,.4<2!,%''45)'2!(25;+'%!!

`\'5'J1M!Z]^<>GZ<':!(-')+4-1!41*%5+;+'%!!

`\'5'J1M!]^[<>G]<':!(-')+4-1!41*%5+;+'%!

`\'5'J1M!^[[!<>:!5-<,.4<2!,%''45)'2!(25;+'%!!

`\'5'J1M!^[[<>GF<':!(-')+4-1!41*%5+;+'%!!

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

1!5%!*-).:!4'!10%%4(+%!,;(!/%!.4(B)%!$2<-'=+4B)%!4/%1+4342!5$%&!'%(!()*%+(!/23454%1+(!%1!6789!,-).!'%(!(,254;'4+2(!5-1+%1;1+!/%!';!B)414/41%F!!

(;!,.4(%!/%!5%!<2/45;<%1+!%(+!,-((4+'%F!

Page 51: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

!

^Z!

925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!,;.+45)'4/.%,!%1!.;4(-1!/A)1!.4(B)%!,;.+45)'4/.%,!%1!.;4(-1!/A)1!.4(B)%!,;.+45)'4/.%,!%1!.;4(-1!/A)1!.4(B)%!,;.+45)'4/.%,!%1!.;4(-1!/A)1!.4(B)%!

,-+%1+4%'!/A$2<-'=(%,-+%1+4%'!/A$2<-'=(%,-+%1+4%'!/A$2<-'=(%,-+%1+4%'!/A$2<-'=(%!!!!

(;!(). %1)%!/A)1%!$2<-'=(%!4<,-.+;1+%!(-)(!+.;4+%<%1+!/-4+!3;4.%!2 -B)%.!)1%!34/ .%!+4'4%)(%!$2<->'-+41).4B)%!/% ;1+!5-1/)4.%!D!'A;..)+!/)!+.;4+%<%1+!,;.!';!B)4141%F!!!8;.!;4''%).(:!'%(!<2/45;<%1+(!5-1+%1;1+!/%!';!B)4141%!(-1+!()(5%,+4+'%(!/A%1+.;R1%.!)1%!$2<-'=(%!;4>)?!5$%&!5%.+;41(!,-.+%).(!/A)1!/23454+!%1&=<;+4B)%!%1!6789!/%!>21-+=,%(!(,25434B)%(F!(;!(). %1)%!/A)1%!$2<-'=(%!B)%!1A%%,'4B)%.;4+!,;(!'A;55/(!,;')(+.%!/-4+!3;4.%!2 -B)%.!';!,-((4+4'4+2!/A)1!/23454+!%1!6789F!!

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

''!%(+!4<,-.+;1+!/%!,.2 %14.! -+.%!<2/%541!(4! -)(!J-)!)1!<%<+.%!/%! -+.%!3;<4''%,!)+%(!;++%41+!/A)1!/23454+!%1!6')5-(%C7C8$-(,$;+%!92($=/.->21;(%!5;.!)1!.4(B)%!/A$2<-'=(%!J/%(+.)5+4-1!/%(!>'-+)'%(!.-)>%(,!%%4(+%!; %5!';!B)4141%F!

184'`\'59_98J.!Z7:H!<>G<':!(4.-,!184'`\'59_98J.!]^[!<>:!5-<,.4<2!,%''45)'2!(25;+'%!`\'5'J1M!Z]^!<>:!5-<,.4<2!,%''45)'2!(25;+'%!`\'5'J1M!Z]^!<>GZ!<':!(-')+4-1!41*%5+;+'%!`\'5'J1M!]^[!<>G]!<':!(-')+4-1!41*%5+;+'%!`\'5'J1M!^[[!<>:!5-<,.4<2!(25;+'%!,%''45)'2!`\'5'J1M!^[[!<>GF!<':!(-')+4-1!41*%5+;+'%!`\'5'5.!#7(98739812.!(1_815!]]F:H^!<>:!5-<,.4<2!

`\'5'5.!#7(98739812.!(1_815!FF":^[!<>:!5-<,.4<2!`\'5'5.!8.51\9'5!]F^!<>G<':!(-')+4-1!41*%5+;+'%!,-).!,%.3)(4-1!'B!

`\'5'5.!4\(_12.!(1_815!]ZH:]!<>:!5-<,.4<2!`\'5'5.!4\(_12.!(1_815!FEF:F!<>:!5-<,.4<2!`\'59_98J.![:^!>G]!<':!(-')+4-1!41*%5+;+'%!%1!;<,-)'%!`\'59_98J.!]Z"!<>GZ!<':!(-')+4-1!41*%5+;+'%!4\8`\'51!]F^!<>G<':!(-')+4-1!,-).!,%.3)(4-1!4\8`\'51!]^[!<>:!5-<,.4<2!,%''45)'2!(25;+'%!

925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!,;.+45)'4/.%,!%1!.;4(-1!/A)1!.4(B)%!,;.+45)'4/.%,!%1!.;4(-1!/A)1!.4(B)%!,;.+45)'4/.%,!%1!.;4(-1!/A)1!.4(B)%!,;.+45)'4/.%,!%1!.;4(-1!/A)1!.4(B)%!

,-+%1+4%'!/A$2<-'=(%!,-+%1+4%'!/A$2<-'=(%!,-+%1+4%'!/A$2<-'=(%!,-+%1+4%'!/A$2<-'=(%!!!!!

(%(!<2/45;<%1+(!5-1+%1;1+!/%!';!B)4141%!(-1+!()(5%,+4+'%(!/0%1+.;R1%.!)1%!$2<-'=(%!;4>)?!5$%&!'%(!()*%+(!,-.+%).(!/0)1!/23454+!%1&=<;+4B)%!%1!6789F!8;.!,.4154,%:!';!,.%(5.4,+4-1!5$%&!5%(!,%.(-11%(!/-4+!,.%1/.%!%1!5-<,+%!5%!.4(B)%:!%+!'%!.%5-).(!D!)1%!;'+%.1;+4 %!+$2.;,%)+4B)%:!(4!%''%!%%4(+%:!%(+!.%5-<<;1/2F!.1!'0;+(%15%!/0;'+%.1;+4 %!+$2.;,%)+4B)%:!';!(). %1)%!/0)1%!$2<-'=(%!2 %1+)%''%!/% .;!)+.%!/2,4(+2%F!!

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

''!%(+!4<,-.+;1+!/%!,.2 %14.! -+.%!<2/%541!(4! -)(!J-)!)1!<%<+.%!/%! -+.%!3;<4''%,!)+%(!;++%41+!/A)1!/23454+!%1!6')5-(%C7C8$-(,$;+%!92($=/.->21;(%!5;.!)1!.4(B)%!/A$2<-'=(%!J/%(+.)5+4-1!/%(!>'-+)'%(!.-)>%(,!%%4(+%!; %5!';!B)4141%!F!

9'51#99.:!5./<%!7.M1`\'5.!19\(2.4:!(),,-(4+-4.%!7.M1`\'5.:!5-<,.4<2!%1.-+2!C'5\8.1C7:!(-')+4-1!41*%5+;+'%!

`\'5'5.!B'21J'5.!#!68159:!5-<,.4<2!%1.-+2!!

`\'5'4.9'5.:!5-<,.4<2!%1.-+2!

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

(013((;!.%5-<<;1/%!/%!1%!,;(!5-1(-<<%.!/%!+-4((-1(!D!+;(%!/%!B)4141%F!

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

(013((;!.%5-<<;1/%!/%!1%!,;(!5-1(-<<%.!/%!+-4((-1(!D!+;(%!/%!B)4141%F!

Page 52: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

!

^]!

#-1+.%#-1+.%#-1+.%#-1+.%CCCC41/4B)2%41/4B)2%41/4B)2%41/4B)2%!!!!

(%!.%5-).(!D!)1%!;'+%.1;+4 %!+$2.;,%)+4B)%!%(+!4<,2.;+43F!

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

(%!.;(+).45;(%!1%!/-4+!,;(!)+.%!)+4'4(2!%1!5;(!/%!/23454+!%1!6789F!1)((4:! -)(!/% %&!;+(-')<%1+!413-.<%.! -+.%!<2/%541! -)(!/% %&!;+(-')<%1+!413-.<%.! -+.%!<2/%541! -)(!/% %&!;+(-')<%1+!413-.<%.! -+.%!<2/%541! -)(!/% %&!;+(-')<%1+!413-.<%.! -+.%!<2/%541!(4! -)(!J-)!)1!<%<+.%!/%! -+.%!3;<4''%,!)+%(!;++%41+!/A)1!/23454+!%1!6')5-(%C7C8$-(,$;+%!92($=/.->21;(%F!

_142\82.#!Z:^<>G<(:!,-)/.%!%+!(-' ;1+!,-).!(-')+4-1!D!/4')%.!,-).!,%.3)(4-1!

925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!,;.+45)'4/.%,!%1!.;4(-1!/%!5;(!-+(%. 2(!,;.+45)'4/.%,!%1!.;4(-1!/%!5;(!-+(%. 2(!,;.+45)'4/.%,!%1!.;4(-1!/%!5;(!-+(%. 2(!,;.+45)'4/.%,!%1!.;4(-1!/%!5;(!-+(%. 2(!

/A$2<-'=(%!;4>)?/A$2<-'=(%!;4>)?/A$2<-'=(%!;4>)?/A$2<-'=(%!;4>)?!!!!

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

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

B-)(!/% %&!413-.<%.! -+.%!<2/%541!(4! -)(!J-)!)1!<%<+.%!/%! -+.%!3;<4''%,!)+%(!;++%41+!/A)1!/23454+!%1!6')5-(%C7C8$-(,$;+%!92($=/.->21;(%!5;.!)1!.4(B)%!/A$2<-'=(%!J/%(+.)5+4-1!/%(!>'-+)'%(!.-)>%(,!%%4(+%!; %5!';!(,4.;<=541%!;/<414(+.2%!,;.! -4%!-.;'%!-)!41*%5+;+'%F!

A'!J'44'((98!Z:^!JF\F'FG]^[!<>:!5-<,.4<2!,%''45)'2!A'899963(:!5-<,.4<2!,%''45)'2!J'44'(98!H^[F[[[!\'GZ]^!<>:!5-<,.4<2!,%''45)'2!899963(:!5-<,.4<2!,%''45)'2!89B1J3#'5.![:H^!J'(('95!\':!5-<,.4<2!,%''45)'2!89B1J3#'5.!Z!^[[![[[!\':!5-<,.4<2!,%''45)'2!89B1J3#'5.!Z:^!J'(('954!9A\5'2.4!'52.8512'951(.4:!'=-,$4'4(;+!,-).!)(;>%!,;.%1+2.;'!

89B1J3#'5.!E!J'(('954!\!':!5-<,.4<2!,%''45)'2!89B1J3#'5.!681594!.5_1524!Z:^!JF\F'F:!>.;1)'2(!,-).!()(,%1(4-1!+) ;+'%!%1!(;5$%+C/-(%!

89B1J3#'5.!59\88'44954![:EH^!JF\F'F:!>.;1)'2(!,-).!()(,%1(4-1!+) ;+'%!%1!(;5$%+C/-(%!

89B1J3#'5.!59\88'44954!EH^![[[!\F'FG^!<':!(4.-,!89B1J3#'5.!59\88'44954!.2!.5_1524![:H^[!JF\F'F:!>.;1)'2(!,-).!()(,%1(4-1!+) ;+'%!%1!(;5$%+C/-(%!

48'81J3#'5.!A'961815!E!JF\F'F:!5-<,.4<2!,%''45)'2!48'81J3#'5.!.6!E!JF\F'F:!5-<,.4<2!,%''45)'2!48'81J3#'5.!J.2895'91D9(.!6'527898!Z:^!J\'G]^[!<>:!5-<,.4<2!,%''45)'2!

48'81J3#'5.!886!Z!^[[![[[!\F'F:!5-<,.4<2!,%''45)'2!48'81J3#'5.!886!E!J'(('954!\F'F:!5-<,.4<2!,%''45)'2!48'81J3#'5.!886!681594!.5_1524!Z:^!JF\F'F:!>.;1)'2(!,-).!()(,%1(4-1!+) ;+'%!%1!(;5$%+C/-(%!

48'81J3#'5.!886!59\88'44954![:EH^!JF\F'F:!>.;1)'2(!,-).!()(,%1(4-1!+) ;+'%!%1!(;5$%+C/-(%!

48'81J3#'5.!886!59\88'44954!.2!.5_1524![:H^[!JF\F'F:!>.;1)'2(!,-).!()(,%1(4-1!+) ;+'%!%1!(;5$%+C/-(%!

48'81J3#'5.!41599D!E!JF\F'F:!5-<,.4<2!,%''45)'2!48'81J3#'5.!4\A42'8718J!E!JF\F'F:!5-<,.4<2!,%''45)'2!48'81J3#'5.!27.818('M!Z!^[[![[[!\F'F:!5-<,.4<2!,%''45)'2!

4;1(!-+*%+!

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

4;1(!-+*%+!

Page 53: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

!

^E!

48'81J3#'5.GJ.2895'91D9(.!16'!8718J1!H^[F[[[!\'GZ]^!<>:!5-<,.4<2!,%''45)'2!

48'81J3#'5.GJ.2895'91D9(.!18896!Z:^!JF\F'FG]^[!<>:!5-<,.4<2!,%''45)'2!

48'81J3#'5.GJ.2895'91D9(.!18896!H^[F[[[!\'GZ]^!<>:!5-<,.4<2!,%''45)'2!

48'81J3#'5.GJ.2895'91D9(.!A'961815!Z:^!JF\F'FG]^[!<>:!5-<,.4<2!,%''45)'2!

48'81J3#'5.GJ.2895'91D9(.!A'961815!H^[F[[[!\'GZ]^!<>:!5-<,.4<2!,%''45)'2!

48'81J3#'5.GJ.2895'91D9(.!#((!8718J1!Z:^!JF\F'FG]^[!<>:!5-<,.4<2!/4(,%.(4+'%!

48'81J3#'5.GJ.2895'91D9(.!9#'!8718J1!Z:^!JF\F'FG]^[!<>:!5-<,.4<2!,%''45)'2!

48'81J3#'5.GJ.2895'91D9(.!.6!Z:^!JF\F'FG]^[!<>:!5-<,.4<2!,%''45)'2!

48'81J3#'5.GJ.2895'91D9(.!.6!H^[F[[[!\'GZ]^!<>:!5-<,.4<2!,%''45)'2!

48'81J3#'5.GJ.2895'91D9(.!6!61J!Z:^!JF\F'FG]^[!<>:!5-<,.4<2!,%''45)'2!

48'81J3#'5.GJ.2895'91D9(.!6!61J!H^[F[[[!\'GZ]^!<>:!5-<,.4<2!,%''45)'2!

48'81J3#'5.GJ.2895'91D9(.!J.8#C!Z:^!JF\F'FG]^[!<>:!5-<,.4<2!,%''45)'2!

48'81J3#'5.GJ.2895'91D9(.!J6!8718J1!H^[F[[[!\'GZ]^!<>:!5-<,.4<2!,%''45)'2!

48'81J3#'5.GJ.2895'91D9(.!J'(6.5!H^[F[[[!\'GZ]^!<>:!5-<,.4<2!,%''45)'2!

48'81J3#'5.GJ.2895'91D9(.!8'.88.!_1A8.!J.9'#1J.52!H^[F[[[!\'GZ]^!<>:!5-<,.4<2!,%''45)'2!

48'81J3#'5.GJ.2895'91D9(.!`\1('J.9!Z:^!JF\F'FG]^[!<>:!5-<,.4<2!,%''45)'2!

48'81J3#'5.GJ.2895'91D9(.!815A1M3!Z:^!JF\F'FG]^[!<>:!5-<,.4<2!,%''45)'2!

48'81J3#'5.GJ.2895'91D9(.!812'98718J!Z:^!JF\F'FG]^[!<>:!5-<,.4<2!,%''45)'2!

48'81J3#'5.GJ.2895'91D9(.!41599D!Z:^!JF\F'FG]^[!<>:!5-<,.4<2!,%''45)'2!

48'81J3#'5.GJ.2895'91D9(.!41599D!H^[F[[[!\'GZ]^!<>:!5-<,.4<2!,%''45)'2!

48'81J3#'5.GJ.2895'91D9(.!46!8718J!H^[F[[[!\'GZ]^!<>:!5-<,.4<2!,%''45)'2!

48'81J3#'5.GJ.2895'91D9(.!4987'1(.!!Z:^!JF\F'FG]^[!<>:!5-<,.4<2!,%''45)'2!

48'81J3#'5.GJ.2895'91D9(.!4987'1(.!H^[F[[[!\'GZ]^!<>:!5-<,.4<2!,%''45)'2!

48'81J3#'5.GJ.2895'91D9(.!4\A42'8718J!H^[F[[[!\'GZ]^!<>:!5-<,.4<2!,%''45)'2!

48'81J3#'5.GJ.2895'91D9(.!2.B1!Z:^!JF\F'FG]^[!<>:!5-<,.4<2!,%''45)'2!

48'81J3#'5.GJ.2895'91D9(.!2.B1!H^[F[[[!\'GZ]^!<>:!5-<,.4<2!,%''45)'2!

48'81J3#'5.GJ.2895'91D9(.!298(15!Z:^!JF\F'FG]^[!<>:!5-<,.4<2!,%''45)'2!

48'81J3#'5.GJ.2895'91D9(.!D39\4!Z:^!JF\F'FG]^[!<>:!5-<,.4<2!,%''45)'2!

!

\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!

/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!!!!!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!!!!!

(;!,.4(%!/%!5%!<2/45;<%1+!%(+!,-((4+'%F!

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

428.829J3#'5.!8158718J1!Z>:!,-)/.%!,-).!,.2,;.;+4-1!41*%5+;+'%!!

428.829J3#'5.!418A1#7!Z!>GF!<'!JH][![[[!\'GF!<',:!(-')+4-1!41*%5+;+'%!!

428.829J3#'5.!48.#'1!Z!>:!,-)/.%!,-).!,.2,;.;+4-1!41*%5+;+'%!

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

1!5%!*-).:!4'!10%%4(+%!,;(!/%!.4(B)%!$2<-'=+4B)%!4/%1+4342!5$%&!'%(!()*%+(!/23454%1+(!%1!6789!,-).!'%(!(,254;'4+2(!5-1+%1;1+!/%!';!(+.%,+-<=541%F!

(;!,.4(%!/%!5%!<2/45;<%1+!%(+!,-((4+'%F!

Page 54: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

!

^F!

\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!

/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!!!!!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!!!!!

(;!,.4(%!/%!5%!<2/45;<%1+!%(+!,-((4+'%F!

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

8.59#'4:!,-)/.%!,-).!(-')+4-1!41*%5+;+'%F!2.-)((%!,-).!';!,.2,;.;+4-1!/%!';!(-')+4-1!41*%5+;+'%!/%!()554</.%C+%5$12+4)<!Y""<!25Z!!

4\##'#1821(!][[<>:!>2')'%!

2.#75.4#15!9J41:!,-)/.%!,-).!(-')+4-1!41*%5+;+'%F!2.-)((%!,-).!';!,.2,;.;+4-1!/%!';!(-')+4-1!41*%5+;+'%!/%!()554</.%!/%!+%5$12+4)<!Y""<25Z!!

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

1!5%!*-).:!4'!10%%4(+%!,;(!/%!.4(B)%!$2<-'=+4B)%!4/%1+4342!5$%&!'%(!()*%+(!/23454%1+(!%1!6789!,-).!'%(!(,254;'4+2(!5-1+%1;1+!/)!()554<%.F!!

(;!,.4(%!/%!5%!<2/45;<%1+!%(+!,-((4+'%F!

925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!,;.+45)'4/.%,!%1!.;4(-1!/%!,;.+45)'4/.%,!%1!.;4(-1!/%!,;.+45)'4/.%,!%1!.;4(-1!/%!,;.+45)'4/.%,!%1!.;4(-1!/%!

'0;,,;.+%1;15%!D!)1%!5';((%!'0;,,;.+%1;15%!D!)1%!5';((%!'0;,,;.+%1;15%!D!)1%!5';((%!'0;,,;.+%1;15%!D!)1%!5';((%!,$;.<;5-'->4B)%!D!.4(B)%!!!!!!,$;.<;5-'->4B)%!D!.4(B)%!!!!!!,$;.<;5-'->4B)%!D!.4(B)%!!!!!!,$;.<;5-'->4B)%!D!.4(B)%!!!!!!!!!!

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

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

''!%(+!4<,-.+;1+!/%!,.2 %14.! -+.%!<2/%541!(4! -)(!J-)!)1!<%<+.%!/%! -+.%!3;<4''%,!)+%(!;++%41+!/0)1!/23454+!%1!6')5-(%C7C8$-(,$;+%!92($=/.->21;(%!5;.!)1!.4(B)%!/0$2<-'=(%!J/%(+.)5+4-1!/%(!>'-+)'%(!.-)>%(,!%%4(+%!; %5!/0;)+.%(!<2/45;<%1+(!/%!';!<)<%!5';((%!B)%!'%!()'3;52+;<4/%F!

152.A98!Z[!>GZ[[!>:!(-')+4-1!,-).!;,,'45;+4-1!5)+;12%!

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

4;1(!-+*%+!

Page 55: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

!

^^!

#-1+.%#-1+.%#-1+.%#-1+.%CCCC41/4B)2%41/4B)2%41/4B)2%41/4B)2%!!!!

(%!.%5-).(!D!)1%!;'+%.1;+4 %!+$2.;,%)+4B)%!%(+!4<,2.;+43F!

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

(;!()'3;/4;&41%!,;.! -4%!-.;'%!1%!/-4+!,;(!)+.%!)+4'4(2%!%1!5;(!/%!/23454+!%1!6789F!1)((4:! -)(!/% %&!;+(-')<%1+!413-.<%.! -)(!/% %&!;+(-')<%1+!413-.<%.! -)(!/% %&!;+(-')<%1+!413-.<%.! -)(!/% %&!;+(-')<%1+!413-.<%.! -+.%!<2/%541! -+.%!<2/%541! -+.%!<2/%541! -+.%!<2/%541!(4! -)(!J-)!)1!<%<+.%!/%! -+.%!3;<4''%,!)+%(!;++%41+!/A)1!/23454+!%1!6')5-(%C7C8$-(,$;+%!92($=/.->21;(%F!

925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!,;.+45)'4/.%,!%1!.;4(-1!/%!5;(!-+(%. 2(!,;.+45)'4/.%,!%1!.;4(-1!/%!5;(!-+(%. 2(!,;.+45)'4/.%,!%1!.;4(-1!/%!5;(!-+(%. 2(!,;.+45)'4/.%,!%1!.;4(-1!/%!5;(!-+(%. 2(!

/A$2<-'=(%!;4>)?/A$2<-'=(%!;4>)?/A$2<-'=(%!;4>)?/A$2<-'=(%!;4>)?!!!!

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

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

B-)(!/% %&!413-.<%.! -+.%!<2/%541!(4! -)(!J-)!)1!<%<+.%!/%! -+.%!3;<4''%,!)+%(!;++%41+!/A)1!/23454+!%1!6')5-(%C7C8$-(,$;+%!92($=/.->21;(%!5;.!)1!.4(B)%!/A$2<-'=(%!J/%(+.)5+4-1!/%(!>'-+)'%(!.-)>%(,!%%4(+%!; %5!';!()'3;/4;&41%!,;.! -4%!'-5;'%F!

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

A8\(\#.8'\J:!5./<%!(+2.4'%!_(1JJ1#.8'\J:!5./<%!(+2.4'%!_(1JJ1D'5.:!5./<%!

4'#1D'5.!Z!89\8!#.52:!5./<%!%1!,-+!4'#1D'5.!Z!89\8!#.52:!5./<%!%1!+)+%!

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

4;1(!-+*%+!

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

19'1D'5.!^[[!<>:!5-<,.4<2!28'J19'1D!1528'J1!59\88'44954!.2!.5_1524:!()(,%1(4-1!+) ;+'%!!

28'J19'1D!1528'J1:!5-<,.4<2!!

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

4;1(!-+*%+!

Page 56: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

!

^7!

925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!,;.+45)'4/.%,!%1!.;4(-1!/%!,;.+45)'4/.%,!%1!.;4(-1!/%!,;.+45)'4/.%,!%1!.;4(-1!/%!,;.+45)'4/.%,!%1!.;4(-1!/%!

'0;,,;.+%1;15%!D!)1%!5';((%!'0;,,;.+%1;15%!D!)1%!5';((%!'0;,,;.+%1;15%!D!)1%!5';((%!'0;,,;.+%1;15%!D!)1%!5';((%!,$;.<;5-'->4B)%!D!.4(B)%!!!!!!!!!!!!,$;.<;5-'->4B)%!D!.4(B)%!!!!!!!!!!!!,$;.<;5-'->4B)%!D!.4(B)%!!!!!!!!!!!!,$;.<;5-'->4B)%!D!.4(B)%!!!!!!!!!!!!!!!!

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

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

''!%(+!4<,-.+;1+!/%!,.2 %14.! -+.%!<2/%541!(4! -)(!J-)!)1!<%<+.%!/%! -+.%!3;<4''%,!)+%(!;++%41+!/A)1!/23454+!%1!6')5-(%C7C8$-(,$;+%!92($=/.->21;(%!5;.!)1!.4(B)%!/A$2<-'=(%!J/%(+.)5+4-1!/%(!>'-+)'%(!.-)>%(,!%%4(+%!; %5!/A;)+.%(!<2/45;<%1+(!/%!';!<)<%!5';((%!B)%!';!()'3;/-%41%F!

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

_154'918:!5-<,.4<2!B);/.4(25;+'%!!

_154'918:!(-')+4-1!41*%5+;+'%!'J!%1!;<,-)'%!!

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

4;1(!-+*%+!

#-1+.%#-1+.%#-1+.%#-1+.%CCCC41/4B)2%41/4B)2%41/4B)2%41/4B)2%!!!!

(%!.%5-).(!D!)1%!;'+%.1;+4 %!+$2.;,%)+4B)%!%(+!4<,2.;+43F!

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

(%!()'3;3).;&-'!1%!/-4+!,;(!)+.%!)+4'4(2!%1!5;(!/%!/23454+!%1!6789F!1)((4:! -)(!/% %&!;+(-')<%1+!413-.<%.! -+.%!<2/%541! -)(!/% %&!;+(-')<%1+!413-.<%.! -+.%!<2/%541! -)(!/% %&!;+(-')<%1+!413-.<%.! -+.%!<2/%541! -)(!/% %&!;+(-')<%1+!413-.<%.! -+.%!<2/%541!(4! -)(!J-)!)1!<%<+.%!/%! -+.%!3;<4''%,!)+%(!;++%41+!/A)1!/23454+!%1!6')5-(%C7C8$-(,$;+%!92($=/.->21;(%F!

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

8.9'1D9(.:!>.;1)'2(!,-).!(4.-,!%1!3';5-1! !

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

4;1(!-+*%+!

Page 57: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

!

^H!

#-1+.%#-1+.%#-1+.%#-1+.%CCCC41/4B)2%41/4B)2%41/4B)2%41/4B)2%!!!!

(%!.%5-).(!D!)1%!;'+%.1;+4 %!+$2.;,%)+4B)%!%(+!4<,2.;+43F!

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

(;!()'3;>);14/41%!1%!/-4+!,;(!)+.%!)+4'4(2%!%1!5;(!/%!/23454+!%1!6789F!1)((4:! -)(!/% %&!;+(-')<%1+!413-.<%.! -+.%!<2/%541! -)(!/% %&!;+(-')<%1+!413-.<%.! -+.%!<2/%541! -)(!/% %&!;+(-')<%1+!413-.<%.! -+.%!<2/%541! -)(!/% %&!;+(-')<%1+!413-.<%.! -+.%!<2/%541!(4! -)(!J-)!)1!<%<+.%!/%! -+.%!3;<4''%,!)+%(!;++%41+!/A)1!/23454+!%1!6')5-(%C7C8$-(,$;+%!92($=/.->21;(%F!

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

1\2.44:!>.;1)'2(!9'18.615:!5-<,.4<2!.52.89#1(J:!5-<,.4<2!.52.8981273(!^[[<>:!5-<,.4<2!

615'915!^[[<>:!5-<,.4<2!('29M9(:!5-<,.4<2!4\(_19'18!^[[<>:!5-<,.4<2!4\(_16\15'9'5.!(1_815!^[[<>!

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

4;1(!-+*%+!

925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!925-1(%4''2%!J(;)3!(4+);+4-1!,;.+45)'4/.%,!%1!.;4(-1!/%!,;.+45)'4/.%,!%1!.;4(-1!/%!,;.+45)'4/.%,!%1!.;4(-1!/%!,;.+45)'4/.%,!%1!.;4(-1!/%!

'0;,,;.+%1;15%!D!)1%!5';((%!'0;,,;.+%1;15%!D!)1%!5';((%!'0;,,;.+%1;15%!D!)1%!5';((%!'0;,,;.+%1;15%!D!)1%!5';((%!,$;.<;5-'->4B)%!D!.4(B)%!!!,$;.<;5-'->4B)%!D!.4(B)%!!!,$;.<;5-'->4B)%!D!.4(B)%!!!,$;.<;5-'->4B)%!D!.4(B)%!!!!!!!

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

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

!''!%(+!4<,-.+;1+!/%!,.2 %14.! -+.%!<2/%541!(4! -)(!J-)!)1!<%<+.%!/%! -+.%!3;<4''%,!)+%(!;++%41+!/A)1!/23454+!%1!6')5-(%C7C8$-(,$;+%!92($=/.->21;(%!5;.!)1!.4(B)%!/A$2<-'=(%!J/%(+.)5+4-1!/%(!>'-+)'%(!.-)>%(,!%%4(+%!; %5!/A;)+.%(!<2/45;<%1+(!/%!';!<)<%!5';((%!B)%!'%!()'3;<2+$4&-'F!

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

8\_9(!Z[[!<>:!5-<,.4<2!

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

4;1(!-+*%+!

Page 58: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

!

^L!

#-1+.%#-1+.%#-1+.%#-1+.%CCCC41/4B)2%41/4B)2%41/4B)2%41/4B)2%!!!!

(%!.%5-).(!D!)1%!;'+%.1;+4 %!+$2.;,%)+4B)%!%(+!4<,2.;+43F!

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

(%!()'3;<2+$-%;&-'%!1%!/-4+!,;(!)+.%!)+4'4(2!%1!5;(!/%!/23454+!%1!6789F!1)((4:! -)(!/% %&!;+(-')<%1+!413-.<%.! -+.%! -)(!/% %&!;+(-')<%1+!413-.<%.! -+.%! -)(!/% %&!;+(-')<%1+!413-.<%.! -+.%! -)(!/% %&!;+(-')<%1+!413-.<%.! -+.%!<2/%541<2/%541<2/%541<2/%541!(4! -)(!J-)!)1!<%<+.%!/%! -+.%!3;<4''%,!)+%(!;++%41+!/A)1!/23454+!%1!6')5-(%C7C8$-(,$;+%!92($=/.->21;(%F!

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

A1#28'J!19\(2.4:!5-<,.4<2!!

A1#28'J!.5_1524:!5-<,.4<2!!

A1#28'J!_982.!'J:!(-')+4-1!41*%5+;+'%!!

A1#28'J!_982.:!5-<,.4<2!!

A1#28'J!59\88'44954!.2!.5_1524:!()(,%1(4-1!+) ;+'%!!

A1#28'J:!(-')+4-1!41*%5+;+'%!,-).!,%.3)(4-1!!

#928'J9M1D9(.!91C921!8718J:!(-')+4-1!,-).!,%.3)(4-1!'B!!

#928'J9M1D9(.!59\88'44954!.2!.5_1524!886:!][[<>GF[<>!,-).!^<':!()(,%1(4-1!+) ;+'%!!!

#928'J9M1D9(.!812'98718J!L[[<>GZ7[<>:!5-<,.4<2!!

#928'J9M1D9(.!886!F[[<>GL[<>:!5-<,.4<2!!

#928'J9M1D9(.!886!19\(2.4!L[[<>GZ7[<>:!5-<,.4<2!(25;+'%!!

.\4188'J!19\(2.4:!5-<,.4<2!!

.\4188'J!.5_1524:!5-<,.4<2!!

.\4188'J!_982!'J:!(-')+4-1!41*%5+;+'%!!

.\4188'J!_982:!5-<,.4<2!!

.\4188'J!59\88'44954!.2!.5_1524:!()(,%1(4-1!+) ;+'%!!

.\4188'J!8.8_\4'95!'B:!(-')+4-1!,-).!,%.3)(4-1!!

4\(_1J.279M1D9(.!28'J.27988'J.!8158718J1!19\(2.4:!5-<,.4<2!!

4\(_1J.279M1D9(.!28'J.27988'J.!8158718J1!59\88'44954!.2!.5_1524:!()(,%1(4-1!+) ;+'%!!

!!

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

4;1(!-+*%+!

Page 59: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

!

^"!

#-1+.%#-1+.%#-1+.%#-1+.%CCCC41/4B)2%41/4B)2%41/4B)2%41/4B)2%!!!!

(%!.%5-).(!D!)1%!;'+%.1;+4 %!+$2.;,%)+4B)%!%(+!4<,2.;+43F!

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

(;!()'3;(;';&41%!1%!/-4+!,;(!)+.%!)+4'4(2%!%1!5;(!/%!/23454+!%1!6789F!1)((4:! -)(!/% %&!;+(-')<%1+!413-.<%.! -+.%!<2/%541! -)(!/% %&!;+(-')<%1+!413-.<%.! -+.%!<2/%541! -)(!/% %&!;+(-')<%1+!413-.<%.! -+.%!<2/%541! -)(!/% %&!;+(-')<%1+!413-.<%.! -+.%!<2/%541!(4! -)(!J-)!)1!<%<+.%!/%! -+.%!3;<4''%,!)+%(!;++%41+!/A)1!/23454+!%1!6')5-(%C7C8$-(,$;+%!92($=/.->21;(%F!

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

41(1D9838'5.!^[[J6:!5-<,.4<2!%1.-+2!>;(+.-C.2(4(+;1+! 41(1D9838'5.:!()(,%1(4-1!,-).!'; %<%1+!

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

4;1(!-+*%+!

\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!!!!!

J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!!!!!

(;!,.4(%!/%!5%!<2/45;<%1+!%(+!,-((4+'%F!

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

27'987.5'#9(:!5-<,.4<2!%1.-+2!!27'987.5'#9(!Z]^!<>G^!<':!>.;1)'2(!,-).!()(,%1(4-1!+) ;+'%!!

27'987.5'#9(!]:^!>:!,-)/.%!,-).!()(,%1(4-1!+) ;+'%!%1!(;5$%+!!!

27'987.5'#9(!H^[!<>:!,-)/.%!%+!(-' ;1+!,-).!,.2,;.;+4-1!41*%5+;+'%!!

\8_1J3#'5.!]:^!>:!,-)/.%!-.;'%!%1!(;5$%+!!

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

1!5%!*-).:!4'!10%%4(+%!,;(!/%!.4(B)%!$2<-'=+4B)%!4/%1+4342!5$%&!'%(!()*%+(!/23454%1+(!%1!6789!,-).!'%(!(,254;'4+2(!5-1+%1;1+!/)!+$4;<,$2145-'F!!

(;!,.4(%!/%!5%!<2/45;<%1+!%(+!,-((4+'%F!

Page 60: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

!

7[!

\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!

/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!!!!!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!!!!!

(;!,.4(%!/%!5%!<2/45;<%1+!%(+!,-((4+'%F!

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

18215.![:F!89\8!#.52:!(-')+4-1!+) ;+'%!%1!>-)++%(!18215.!Z[!<>G^!<':!(-')+4-1!41*%5+;+'%!%1!;<,-)'%!18215.!]!<>:!5-<,.4<2!!18215.!^!<>:!5-<,.4<2!

818C'515.!(8!]!<>:!>2')'%!D!'4+2.;+4-1!,.-'-1>2%!!818C'515.!(8!^!<>:!>2')'%!D!'4+2.;+4-1!,.-'-1>2%!!28'7.M3!]!<>!8'#7189:!5-<,.4<2!28'7.M3!^!<>!8'#7189:!5-<,.4<2!

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

1!5%!*-).:!4'!10%%4(+%!,;(!/%!.4(B)%!$2<-'=+4B)%!4/%1+4342!5$%&!'%(!()*%+(!/23454%1+(!%1!6789!,-).!'%(!(,254;'4+2(!5-1+%1;1+!/)!+.4$%%=,$214/='%F!!

(;!,.4(%!/%!5%!<2/45;<%1+!%(+!,-((4+'%F!

Page 61: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

!

7Z!

#-1+.%#-1+.%#-1+.%#-1+.%CCCC41/4B)2%41/4B)2%41/4B)2%41/4B)2%!!!!

(%!.%5-).(!D!)1%!;'+%.1;+4 %!+$2.;,%)+4B)%!%(+!4<,2.;+43F!

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

(%!+.4<2+$-,.4<%!1%!/-4+!,;(!)+.%!)+4'4(2!%1!5;(!/%!/23454+!%1!6789F!1)((4:! -)(!/% %&!;+(-')<%1+!413-.<%.! -+.%!<2/%541 -)(!/% %&!;+(-')<%1+!413-.<%.! -+.%!<2/%541 -)(!/% %&!;+(-')<%1+!413-.<%.! -+.%!<2/%541 -)(!/% %&!;+(-')<%1+!413-.<%.! -+.%!<2/%541!(4! -)(!J-)!)1!<%<+.%!/%! -+.%!3;<4''%,!)+%(!;++%41+!/A)1!/23454+!%1!6')5-(%C7C8$-(,$;+%!92($=/.->21;(%F!

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

A1#28'J!19\(2.4:!5-<,.4<2!!

A1#28'J!.5_1524:!5-<,.4<2!!

A1#28'J!_982.!'J:!(-')+4-1!41*%5+;+'%!!!

A1#28'J!_982.:!5-<,.4<2!!

A1#28'J!59\88'44954!.2!.5_1524:!()(,%1(4-1!+) ;+'%!!

A1#28'J:!(-')+4-1!41*%5+;+'%!,-).!,%.3)(4-1!!

#928'J9M1D9(.!91C921!8718J:!(-')+4-1!,-).!,%.3)(4-1!'B!!

#928'J9M1D9(.!59\88'44954!.2!.5_1524!886:!][[<>GF[<>!,-).!^<':!()(,%1(4-1!+) ;+'%!!!

#928'J9M1D9(.!812'98718J!L[[<>GZ7[<>:!5-<,.4<2!!

#928'J9M1D9(.!886!F[[<>GL[<>:!5-<,.4<2!!

#928'J9M1D9(.!886!19\(2.4!L[[<>GZ7[<>:!5-<,.4<2!(25;+'%!!

9.(88'J!E[[<>:!5-<,.4<2!!

.\4188'J!19\(2.4:!5-<,.4<2!!

.\4188'J!.5_1524:!5-<,.4<2!!

.\4188'J!_982!'J:!(-')+4-1!41*%5+;+'%!!

.\4188'J!_982:!5-<,.4<2!!

.\4188'J!59\88'44954!.2!.5_1524:!()(,%1(4-1!+) ;+'%!!

.\4188'J!8.8_\4'95!'B:!(-')+4-1!,-).!,%.3)(4-1!!

4\(_1J.279M1D9(.!28'J.27988'J.!8158718J1!19\(2.4:!5-<,.4<2!!

4\(_1J.279M1D9(.!28'J.27988'J.!8158718J1!59\88'44954!.2!.5_1524:!()(,%1(4-1!+) ;+'%!!

4\88'429(!19\(2.4:!5-<,.4<2!!28'J19'1D!1528'J1!59\88'44954!.2!.5_1524:!()(,%1(4-1!+) ;+'%!!

28'J19'1D!1528'J1:!5-<,.4<2!!

!

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,4;1(!-+*%+!

Page 62: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase

!

7]!

\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!\+4'4(;+4-1!,-((4+'%!;,./(!;1;'=(%!/%(!

/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!/-112%(!/4(,-14+'%(!!!!!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!J'4++2.;+).%!%+!,$;.<;5- 4>4';15%,!!!!!

(;!,.4(%!/%!5%!<2/45;<%1+!%(+!,-((4+'%F!

!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,!"#$%%&'(&)*$'+,-&.)*#/0*1."+,2,03&))"')*$',("+,-.$4"++*$''"0+,(",+&')5,,,,,

6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:6$'(/*)",2,)"'*.,2,03&))"')*$',("+,-&)*"')+,(54*#*)&*."+,"',789:,,,,

;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+;'4$.%&)*$'+,#$%-05%"')&*."+,,,,

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

(.5'281(!8.8#\215.:!,-<<;/%!512'894.![:H^!<>:!5-<,.4<2!%1.-+2!512'48813![:Z^!<>G/-(%:!(-')+4-1!,-).!,)' 2.4(;+4-1!+)55;'%!!!

512'48813![:E[!<>G/-(%:!(-')+4-1!,-).!,)' 2.4(;+4-1!+)55;'%!

5'28'9.8J!224!Z[!<>G]F!$:!/4(,-(4+43!+.;1(/%.<4B)%!5'28'9.8J!224!Z^!<>G]F!$:!/4(,-(4+43!+.;1(/%.<4B)%!!5'28'9.8J!224!^!<>G]F!$:!/4(,-(4+43!+.;1(/%.<4B)%!!5'2899\8!Z[!<>G!]F!$%).%(:!/4(,-(4+43!+.;1(/%.<4B)%!5'2899\8!^!<>G!]F!$%).%(:!/4(,-(4+43!+.;1(/%.<4B)%!5'28951(!Z!<>G<':!(-')+4-1!,-).!,%.3)(4-1!5'28951(48813:!(-')+4-1!,-).!,)' 2.4(;+4-1!+)55;'%!%1!3';5-1!

8.#296.4'#![:F!S:!,-<<;/%!.%5+;'%!28'5'812#7!Z[!<>G]F!$!/4(,-(4+43!+.;1(/%.<4B)%!JFFFL<>GZF5<],!

28'5'812#7!Z^!<>G]F!$!/4(,-(4+43!+.;1(/%.<4B)%!!28'5'812#7!^!<>G]F!$!/4(,-(4+43!+.;1(/%.<4B)%!J]]FF<>GH5<],!

28'5'28'5.!J.8#C!Z[!<>G]F!$%).%(:!/4(,-(4+43!+.;1(/%.<4B)%!!!

28'5'28'5.!J.8#C!^!<>G]F!$%).%(:!/4(,-(4+43!+.;1(/%.<4B)%!!!

28'5'28'5.!8'.88.!_1A8.!Z[!<>G]F!$%).%(:!/4(,-(4+43!+.;1(/%.<4B)%!!

28'5'28'5.!8'.88.!_1A8.!^!<>G]F!$%).%(:!/4(,-(4+43!+.;1(/%.<4B)%!!

28'5'28'5.!4'J8(.!(1(.\_![:Z^!<>:!,4')'%!%1.-+2%!!

<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+<-5#*&0*)5+,,,,

1!5%!*-).:!4'!10%%4(+%!,;(!/%!.4(B)%!$2<-'=+4B)%!4/%1+4342!5$%&!'%(!()*%+(!/23454%1+(!%1!6789!,-).!'%(!(,254;'4+2(!5-1+%1;1+!/%!';!+.414+.41%F!!

(;!,.4(%!/%!5%!<2/45;<%1+!%(+!,-((4+'%F!

Page 63: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase
Page 64: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase
Page 65: M dicam ents et d ficit en G lucose-6-P hosphate D shydrog ...vigifavisme.com/indexparsubstancesactivesG6PD.pdf · M dicam ents et d ficit en G lucose-6-P hosphate D shydrog nase